_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e53
_enti_e59
_enti_e54
_enti_e52
_enti_e50
_enti_e56
_enti_e51
_enti_e61
_enti_e58
_enti_e57
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g14
g1_fact_g1
g2_fact_g12
g2_fact_g13
p1_propro_p1
PMID: 10473535, 8663020
Cp markedly enhanced LDL oxidation by both cell types.
PMID: 10473535
Cell-derived superoxide anion (Obardot 2) was essential for the enhancement of LDL oxidation by Cp under these conditions.
c1 cso30:c:InputProcess connector
c3 cso30:c:InputAssociation connector
c4 cso30:c:InputAssociation connector
c2 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 10473535, 8609249
Exogenous Cp added to unactivated U937 cells caused LDL oxidation to an extent similar to that by zymosan in the absence of exogenous Cp.
c5 cso30:c:InputProcess connector
c7 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 10473535, 8609249
Zymosan induced Cp mRNA and (after a 5-6-h lag following activation) Cp protein synthesis.
c11 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p4_propro_p4
c8 cso30:c:InputAssociation connector
c9 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 10473535, 1996664, 9257859
Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.
c12 cso30:c:InputAssociation connector
c17 cso30:c:InputAssociation connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 10473535, 1996664, 9257859
Factors that stimulate monocyte-macrophage Cp production and could contribute to Cp accumulation in vivo include endotoxin and interferon (IFN)-gamma.
c15 cso30:c:InputAssociation connector
c16 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.
c18 cso30:c:InputProcess connector
c20 cso30:c:InputAssociation connector
c21 cso30:c:InputAssociation connector
c19 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.
PMID: 10473535, 9261183
Angiotensin II enhanced both LO activity and LDL oxidation in mouse peritoneal macrophages and J774 cells.
c22 cso30:c:InputProcess connector
c24 cso30:c:InputAssociation connector
c25 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 10473535
They catalyze the direct insertion of molecular oxygen into polyenoic fatty acids, forming hydroperoxides.
c26 cso30:c:InputProcess connector
c28 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 10473535
MPO can catalyze the one-electron oxidation of L-tyrosine, generating the tyrosyl radical.
c29 cso30:c:InputProcess connector
c31 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 10473535
MPO catalyzes the two-electron oxidation of chloride forming the powerful oxidant, hypochlorous acid (HOCl).
c32 cso30:c:InputProcess connector
c34 cso30:c:InputAssociation connector
c33 cso30:c:OutputProcess connector
p7_propro_p12
PMID: 10473535, 3139813, 1901344
Incubation of LDL with 15-LO plus phospholipase A2 led to LDL oxidation in a cell-free system; however, 15-LO alone was also shown to oxidize LDL significantly in the absence of cells.
c35 cso30:c:InputProcess connector
c37 cso30:c:InputAssociation connector
c36 cso30:c:OutputProcess connector
LDL_enti_MO000000290
LDL
ceruloplasmin_enti_e5
ceruloplasmin
oxLDL_enti_MO000107436
oxLDL
O2-_enti_e6
O2-
O2-
Zymosan_enti_e11
Zymosan
ceruloplasmin_enti_e12
ceruloplasmin
endotoxin_enti_e13
endotoxin
IFN-gamma_enti_e14
IFN-gamma
15-lipoxygenase_enti_e15
15-lipoxygenase
PLA2_enti_MO000016723
PLA2
angiotensin-II_enti_e16
angiotensin-II
Fatty acids_enti_e17
Fatty acids
hydroperoxides_enti_e18
hydroperoxides
LO_enti_e19
LO
tyrosyl radical_enti_e20
tyrosyl radical
L-tyrosine_enti_e21
L-tyrosine
MPO_enti_e22
MPO
chloride_enti_e23
Chloride
chloride
HOCL_enti_e24
HOCL
HOCL