1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10534106.csml convertedTime:2009.07.01.10:38

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The actions of bacterial DNA on murine macrophages.
Authors Sester DP, Stacey KJ, Sweet MJ, Beasley SJ, Cronau SL, Hume DA.
Affiliation Centre for Molecular and Cellular Biology, and Department of Microbiology,University of Queensland, Australia.
Abstract Murine macrophages are able to distinguish bacterial from mammalian DNA. Theresponse is mimicked by single-stranded oligonucleotides containing unmethylatedCG dinucleotides ("CpG" motifs) in specific sequence contexts. The dose-responsecurve for activation is influenced by variation in the sequence flanking thecore CpG motif. CpG or bacterial DNA activates several signaling pathways incommon with bacterial lipopolysaccharide (LPS), leading to induction of cytokinegenes such as tumor necrosis factor alpha. Pretreatment with LPS causesdesensitization to subsequent activation by CpG DNA. Both stimuli also causecell cycle arrest in macrophages proliferating in response to the macrophagegrowth factor colony-stimulating factor-1 (CSF-1), but prevent apoptosis causedby growth factor removal. In part, cell cycle arrest by CpG DNA and LPS may belinked to rapid down-modulation of the CSF-1 receptor from the cell surface, aresponse that occurs in an all-or-nothing manner. The response of macrophages toCpG DNA has aspects in common with the DNA damage response in other cell types,which may provide clues to the underlying mechanism.
PMID 10534106
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010345:PAI-2 G010389:IL-1beta G010453:IFN-gamma G010514:iNOS G012247:CSF1 MO000000009:Raf MO000000015:Raf-1 MO000000058:NF-kappaB MO000000077:MAPKs MO000000100:M-CSF MO000000212:TRAF6{active} MO000000213:IRAK{active} MO000000289:TNF-alpha MO000004670:ERK1 MO000004676:ERK2 MO000007384:IL-6 MO000007995:M-CSF-1-R MO000016573:MyD88{active} MO000016597:IL-1beta MO000016665:IFNgamma MO000016882:LPS MO000017265:IL-12 MO000019394:TLR4 MO000021201:iNOS MO000033676:IL-12R e1: e10: e11:IFNgamma:R e12:CpGDNA e13:CpG DNA receptor e14:PAI-2 e15:CpGDNA e16:Il-12 e17:LPS:TLR4 e18:JNK e19:p38 e2: e20:NF-kappaB{active} e21:ERK2{active} e22:ERK1{active} e23:p38{active} e24:JNK{active} e25:CSF1R e26:M-CSF-1-R e27:Raf{active} e28:Ras e29:Raf-1{active} e3: e30:M-CSF:M-CSF-1-R e31:Ras{active} e32:MAPKs{active} e33:Ets2 e34:Ets2{p} e35: e36: e37: e38: e39:M-CSF-1-R e4: e40:M-CSF-1-R{p} e41:ERK1{p} e42:ERK2{p} e43:MyD88 e44:IRAK e45:TRAF6 e5:IL-12:IL-12R e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFNgammaR e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p6 p7 p8 p9
Model Detail
618.0, 842.0
36.0, 36.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
609.0, 717.0
29.5, 29.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p2

p4

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
440.0, 656.0
32.0, 32.0

PAI-2

--

G010345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m93323

10

false

infinite

0

unit false false false
TRANSFACG010345

--

Go back
605.0, 785.0
29.5, 29.5

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
571.0, 903.0
34.0, 34.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p8

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
563.0, 987.0
34.0, 34.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
326.0, 774.0
36.0, 36.0

CSF1

--

G012247

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m95036

10

false

infinite

0

unit false false false
TRANSFACG012247

--

Go back
520.0, 1220.0
32.0, 32.0

Raf

--

MO000000009

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p50

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
625.0, 1145.0
30.0, 30.0

Raf-1

--

MO000000015

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
213.0, 181.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p23 p28

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
931.0, 1283.0
34.0, 34.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
83.0, 707.0
34.0, 34.0

M-CSF

--

MO000000100

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008001
TRANSPATHMO000000100

--

Go back
416.0, 164.0
32.5, 32.5

TRAF6{active}

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
318.0, 526.0
28.0, 28.0

IRAK{active}

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1135.0, 659.0
33.0, 33.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
827.0, 179.0
33.0, 33.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p26 p31 p17

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
900.0, 152.0
31.0, 31.0

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p27 p32 p18

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
1153.0, 789.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
146.0, 786.0
36.0, 36.0

M-CSF-1-R

--

MO000007995

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1031

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007995

--

Go back
336.0, 84.0
32.0, 32.0

MyD88{active}

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1133.0, 721.0
29.0, 29.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
1142.0, 890.0
28.0, 28.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
70.0, 478.0
36.0, 36.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p38 p44 p45

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1130.0, 602.0
27.0, 27.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p7

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
142.0, 598.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
960.0, 968.0
32.0, 32.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
1031.0, 627.0
34.0, 34.0

IL-12R

--

MO000033676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m12340

10

false

infinite

0

unit false false false
TRANSPATHMO000033676

--

Go back
128.75, 12.829820105231697
957.9663427269318, 1390.967129639504

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
163.48300581899656, 12.203460233289206
904.4871398403077, 1272.3590779278802

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1034.5, 903.0
26.289848717386537, 50.88357816268363

IFNgamma:R

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
803.7291088109063, 507.19755112345365
55.91012370613481, 17.70487250694269

CpGDNA

--

e12

cso30:c:Dna

cso30:i:CC_EndosomeLumen

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1028.5, 288.0
31.506151142355012, 48.47100175746924

CpG DNA receptor

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
484.0, 555.5
39.146709599516996, 24.140470919702153

PAI-2

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1130.0, 374.5
60.0, 19.0

CpGDNA

--

e15

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
603.0, 655.0
50.397923875432525, 26.87889273356401

Il-12

--

e16

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
146.5, 453.0
27.751151063363295, 53.71190528392896

LPS:TLR4

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
545.0, 252.5
30.39999999999999, 22.799999999999997

JNK

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p19 p24 p29

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
803.5, 316.0
24.110686254779637, 39.09841014288589

p38

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p20 p25 p30

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
128.75, 12.829820105231697
957.9663427269318, 1390.967129639504

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
257.0, 273.0
30.0, 30.0

NF-kappaB{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p23 p28

--

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
976.0, 236.0
31.0, 31.0

ERK2{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p27 p32

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
743.0, 191.0
33.0, 33.0

ERK1{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p26 p31

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
607.5, 228.0
24.110686254779637, 39.09841014288589

p38{active}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16 p20 p25 p30

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
453.0, 216.5
30.39999999999999, 22.799999999999997

JNK{active}

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15 p19 p24 p29

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
364.0, 840.0
40.0, 40.0

CSF1R

--

e25

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSFACG010435

--

Go back
210.0, 1142.0
36.0, 36.0

M-CSF-1-R

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007995

--

Go back
660.0, 1228.0
32.0, 32.0

Raf{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
259.0, 1198.0
18.666978484565014, 43.0776426566885

Ras

--

e28

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p43 p49

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
737.0, 1189.0
30.0, 30.0

Raf-1{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
147.90932685453862, 31.98914695977038
919.6476890178548, 1352.6484759304271

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
146.5, 883.0
26.317035737776802, 50.93619820214865

M-CSF:M-CSF-1-R

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
415.0, 1158.0
18.666978484565014, 43.0776426566885

Ras{active}

--

e31

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
859.0, 1159.0
34.0, 34.0

MAPKs{active}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
226.0, 1272.5
36.22459247333467, 22.338498691889715

Ets2

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
378.0, 1282.0
35.0, 27.999999999999996

Ets2{p}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
853.6544264921885, 1037.4136066230476
111.63386299906529, 12.496327947656564

--

e35

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiTransFace

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
812.0, 1027.0
199.94124716250502, 82.4757644545333

--

e36

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiMembrane

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
812.0, 1027.0
199.94124716250502, 82.4757644545333

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiApparatus

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
812.0, 1027.0
199.94124716250502, 82.4757644545333

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_GolgiLumen

--

--

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false true false

--

Go back
886.0, 1046.0
36.0, 36.0

M-CSF-1-R

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007995

--

Go back
183.3540815354352, 65.51796895521272
848.7581796560617, 1285.5908319395412

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
142.0, 1018.0
42.560975609756085, 34.04878048780488

M-CSF-1-R{p}

--

e40

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p48

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
803.0, 415.0
33.0, 33.0

ERK1{p}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
920.0, 348.0
31.0, 31.0

ERK2{p}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
208.0, 120.0
32.0, 32.0

MyD88

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
338.0, 614.0
28.0, 28.0

IRAK

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
316.0, 188.0
32.5, 32.5

TRAF6

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1034.5, 478.0
27.051085288313963, 52.35693926770445

IL-12:IL-12R

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p8

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
251.0, 594.0
586.0550559616997, 531.48754609562

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
314.2983114446528, 606.5954821811079
342.68396195898276, 515.1172931357959

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
258.63945138125126, 601.0937762825905
570.7761531991979, 517.299993530439

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
259.73080157857277, 602.1851264799119
568.5934528045542, 515.1172931357959

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
251.0, 594.0
586.0550559616997, 531.48754609562

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
251.0, 594.0
586.0550559616997, 531.48754609562

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
259.73080157857277, 602.1851264799119
568.5934528045542, 515.1172931357959

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
678.8092773500671, 812.27003946432
36.61349981459451, 33.144852463738225

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
582.7704599857668, 965.0590670893444
103.67826874555206, 93.85611696965776

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
251.0, 594.0
586.0550559616997, 531.48754609562

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1034.5, 759.0
27.32513181019332, 42.03866432337434

IFNgammaR

--

e6

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p10

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
389.1298791853451, 830.1886737671456
18.559502504857406, 8.936056761598016

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
388.5101248625219, 803.5392378857474
63.524818089379984, 114.34467256088394

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
415.1595607439209, 877.909756624534
9.916069165171496, 9.9160691651715

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
122.48702789082694, 121.86722771246329
805.2367076058072, 1140.9996152052768

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
177.0, 183.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
188.0, 59.48721586291782
840.4423170334005, 1209.8416144930602

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
929.0, 405.0
30.0, 30.0

p1

p1

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c5 : 1

m15*m13*0.1

nodelay

--

true

0

false

PMID: 10534106 To activate cells, CpG DNA probably needs to be internalized via the endosomes. Although internalization of DNA appears to be essential for the biological response, the possibility that a co-stimulatory signal comes from a membrane receptor during the process of internalization should not be discounted.

Go back
1101.0, 825.0
29.0, 29.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c31 : 1

m1639*m6*0.1

nodelay

--

true

0

false

PMID: 10534106 Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells PMID: 10534106, 1401905 Baccarini et al reported an increase in serine phosphorylation of the receptor in Bac1.2F5 cells treated with interferon-g plus LPS.

Go back
887.0, 979.0
25.0, 25.0

p11

p11

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m93479*0.1

nodelay

--

true

0

false

PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS) Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells

Go back
590.0, 558.0
27.0, 27.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m93323*m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS)

Go back
71.0, 579.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
290.0, 146.0
27.0, 27.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c65 : 1
stoichiometry:c52 : 1

m1572*m17*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
623.0, 323.0
25.0, 25.0

p14

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m12*m19*0.1

nodelay

--

true

0

false

PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells

Go back
655.0, 263.0
25.0, 25.0

p14

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m12*m20*0.1

nodelay

--

true

0

false

PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells

Go back
855.0, 287.0
25.0, 25.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m549*m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells PMID: 10534106, 10586047 More recently, we confirmed that CpG DNA can mimic the ability of CSF-1 to activate phosphorylation of the MAP kinases ERK-1 and ERK-2 in macrophages

Go back
887.0, 283.0
25.0, 25.0

p17

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c162 : 1

m12*m554*0.1

nodelay

--

true

0

false

PMID: 10534106, 9799232, 9568729 The latter (MAP kinases) are also activated by CpG DNA in myeloid cells PMID: 10534106, 10586047 More recently, we confirmed that CpG DNA can mimic the ability of CSF-1 to activate phosphorylation of the MAP kinases ERK-1 and ERK-2 in macrophages

Go back
470.0, 154.0
27.0, 27.0

p14

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c66 : 1
stoichiometry:c55 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
485.0, 697.0
29.0, 29.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS)

Go back
574.0, 150.0
27.0, 27.0

p14

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c67 : 1
stoichiometry:c58 : 1

m1572*m20*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
730.0, 126.0
27.0, 27.0

p14

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c68 : 1
stoichiometry:c61 : 1

m1572*m549*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
962.0, 102.0
27.0, 27.0

p14

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c69 : 1
stoichiometry:c64 : 1

m1572*m554*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
238.0, 518.0
27.0, 27.0

p14

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m184*m17*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
374.0, 398.0
27.0, 27.0

p14

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m184*m19*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
446.0, 470.0
27.0, 27.0

p14

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m184*m20*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
662.0, 438.0
27.0, 27.0

p14

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m184*m549*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
498.0, 338.0
27.0, 27.0

p14

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m184*m554*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
330.0, 234.0
27.0, 27.0

p14

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m183*m17*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
374.0, 318.0
27.0, 27.0

p14

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1

m183*m19*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
916.0, 592.0
24.0, 24.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m12*m16*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.

Go back
582.0, 374.0
27.0, 27.0

p14

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m183*m20*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
542.0, 526.0
27.0, 27.0

p14

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m183*m549*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
646.0, 510.0
27.0, 27.0

p14

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m183*m554*0.1

nodelay

--

true

0

false

PMID: 10534106, 10334979 In the case of LPS signaling, it is now appreciated that such upstream activators include members of the IL-1 receptor signaling pathway, such as MyD88, IL-1 receptor-associated kinases (IRAK) and TRAF 6 PMID: 10534106, 10354505 LPS inhibits its own actions upstream of a branching point in the signaling cascade for activation of NF-kB and the MAP kinases (SAPK/JNK, p38, and ERK1/2).

Go back
45.0, 809.0
30.0, 30.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c133 : 1

m89*m1031*0.1

nodelay

--

true

0

false

PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2 PMID: 10534106 CSF-1 can activate Raf-1 in a ras-independent manner.

Go back
386.0, 694.0
27.0, 27.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c114 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 10534106, 10354505, 6092475, 1401905, 2548952 LPS has been shown previously to cause rapid down-regulation of CSF-1 binding to murine macrophages

Go back
217.0, 717.0
30.0, 30.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c113 : 1

m95036*0.1

nodelay

--

true

0

false

PMID: 10534106, 10354505, 6092475, 1401905, 2548952 LPS has been shown previously to cause rapid down-regulation of CSF-1 binding to murine macrophages

Go back
412.0, 788.0
24.0, 24.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c43 : 1
stoichiometry:c112 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface. PMID: 10534106, 8497248 Indeed, down-modulation of the receptor from the cell surface is followed, at least in the case of LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R

Go back
216.0, 800.0
24.0, 24.0

p37

p37

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface.

Go back
265.0, 85.0
30.0, 30.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c137 : 1
stoichiometry:c119 : 1

m46*m155666*0.1

nodelay

--

true

0

false

--

Go back
222.0, 882.0
27.0, 27.0

p39

p39

cso30:i:ME_Internalization

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m1031*m18*0.1

nodelay

--

true

0

false

PMID: 10534106 The biological importance of the specific internalization of the CSF-1R in response to CpG DNA and LPS is not known.

Go back
900.0, 656.0
24.0, 24.0

p3

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c11 : 1
stoichiometry:c10 : 1

m93309*m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.

Go back
290.0, 1062.0
27.0, 27.0

p39

p40

cso30:i:ME_Internalization

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m12*m1031*0.1

nodelay

--

true

0

false

PMID: 10534106 The biological importance of the specific internalization of the CSF-1R in response to CpG DNA and LPS is not known.

Go back
555.0, 1151.0
25.0, 25.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m18*m28*0.1

nodelay

--

true

0

false

PMID: 10534106, 7799956 More recently the same group claimed that activation of Raf in LPS-stimulated cells was ras-independent

Go back
719.0, 1115.0
25.0, 25.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c143 : 1
stoichiometry:c132 : 1

m31*m33*0.1

nodelay

--

true

0

false

PMID: 10534106 CSF-1 can activate Raf-1 in a ras-independent manner.

Go back
322.0, 1142.0
27.0, 27.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m33*m30*0.1

nodelay

--

true

0

false

PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2

Go back
289.0, 573.0
30.0, 30.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1

m47*m155666*0.1

nodelay

--

true

0

false

--

Go back
365.0, 169.0
30.0, 30.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c163 : 1
stoichiometry:c142 : 1

m48*m155666*0.1

nodelay

--

true

0

false

--

Go back
313.0, 1277.0
29.0, 29.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m33*m36*0.1

nodelay

--

true

0

false

PMID: 10534106, 9710599 We have demonstrated the constitutive activation of this pathway in response to CSF-1, and its role in phosphorylation of the transcription factor Ets2

Go back
756.0, 1068.0
24.0, 24.0

p37

p47

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10534106 Both LPS and bacterial DNA or CpG oligonucleotides cause rapid down-modulation of the CSF-1R from the cell surface. PMID: 10534106, 8497248 Indeed, down-modulation of the receptor from the cell surface is followed, at least in the case of LPS, by specific repression of c-fms (CSF-1R) mRNA transcription and RAW264 macrophage cells treated with LPS or CpG DNA for a prolonged period deplete both their cell surface and intracellular Golgi-associated pool of CSF-1R

Go back
229.0, 1041.0
29.0, 29.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c150 : 1

m1031*m18*m11*0.1

nodelay

--

true

0

false

PMID: 10534106, 1401905 Baccarini et al reported an increase in serine phosphorylation of the receptor in Bac1.2F5 cells treated with interferon-g plus LPS.

Go back
355.0, 1219.0
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m27*m30*0.1

nodelay

--

true

0

false

PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.

Go back
884.0, 720.0
24.0, 24.0

p3

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c14 : 1
stoichiometry:c13 : 1

m93364*m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.

Go back
563.0, 1295.0
25.0, 25.0

p49

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m34*m28*0.1

nodelay

--

true

0

false

PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.

Go back
703.0, 1299.0
25.0, 25.0

p49

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m29*m69*0.1

nodelay

--

true

0

false

PMID:10534106 One possibility is that after internalization the receptor provides a CSF-1-independent signal to the ras-raf-MAP kinase pathway.

Go back
864.0, 792.0
24.0, 24.0

p3

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m12*m93248*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 10689778, 9464831 CpG DNA induces a range of cytokines in macrophages/ dendritic cells, including interleukin-12 (IL-12), tumor necrosis factor a (TNF-a), IL-1b, and IL-6.

Go back
1105.0, 517.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m12340*m2121*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 8648098 In mixed spleen cell culture, CpG DNA-induced macrophage IL-12 promotes interferon-g production by NK cells

Go back
891.0, 851.0
25.0, 25.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m5*m93423*0.1

nodelay

--

true

0

false

PMID: 10534106, 9245551, 8648098 In mixed spleen cell culture, CpG DNA-induced macrophage IL-12 promotes interferon-g production by NK cells

Go back
696.0, 952.0
24.0, 24.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 10534106, 9568729, 8757335 In comparison to the response to LPS, CpG DNA was as effective at increasing TNF-a mRNA in bone marrow-derived murine macrophages, whereas it was a less effective inducer of IL-1b and plasminogen activator inhibitor type-2 and did not, by itself, lead to production of inducible nitric oxide synthase (iNOS) Interferon-g in turn primes murine macrophages to respond to CpG DNA with expression of iNOS and nitric oxide production as well as increasing a number of other responses, creating a potential self-amplifying loop with NK cells

Go back
966.8873796195873, 389.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 668.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 274.8767818166191

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 391.8250088454535

c101

c101

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
438.0, 197.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.1368283631906, 212.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 230.82178377912663

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 482.0

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
443.0, 197.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
674.6686790166359, 183.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 270.0670148473297

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 481.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
837.0, 525.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
174.0, 494.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
174.0, 497.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
401.4920113466981, 812.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
124.98563876372623, 725.4791383258236

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.4084922779337, 721.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.06376772628767, 743.7554208165074

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
247.64889459889582, 818.3440160867584

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
189.94520483458302, 806.9347299805391

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 113.31242957138694

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.0, 100.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 736.9035506472895

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 822.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
229.2402349568245, 909.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
165.0, 507.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.492033947753, 525.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
173.0, 822.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.3702354610118, 1089.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 504.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 1183.282931819701

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 1173.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
68.95226358329872, 741.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 732.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
82.84886842389474, 807.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 1135.6006381480884

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 1140.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.0, 837.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 926.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 1174.52380597346

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 1159.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
97.0, 122.1985128575696

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.1192895849364, 605.1530859662622

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 560.923410283849

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 525.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
106.0, 504.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.0, 193.20655067215768

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 181.75847274102395

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
173.0, 913.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
171.0, 934.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
262.0, 1286.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 1293.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 871.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
780.0, 1066.9738357069946

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 822.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 525.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
192.76114000116266, 1042.9402850002907

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
164.0, 507.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.90003199283143, 930.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
246.0, 1169.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.0, 1221.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.0, 1193.488102949512

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.0, 1188.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.0, 1252.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 1258.3071142168176

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 1260.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
654.0, 808.8178369248513

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.9903110128192, 1301.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 1195.198681743486

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0, 308.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
105.0, 204.84217130815117

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.0, 804.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1059.0, 553.7458175844586

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1126.234636326641, 554.6815623728286

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.4612860040783, 329.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1069.4396857613915, 511.94127111496874

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.9631410951346, 530.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.0, 867.4044188775489

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.0, 866.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.1716000756319, 860.8262546692157

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.0, 792.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.9538021154395, 929.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.1476659023066, 525.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.6344663941372, 968.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 992.3032302160033

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.8878647389515, 525.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 986.8288486740756

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1065.8884174207467, 854.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 585.4892664309411

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.7684156026912, 523.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.9964381120229, 569.2386996451351

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
85.2460374062958, 514.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.65339104343087, 598.3292929262616

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.0, 506.60450800935604

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 212.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.7690194437737, 312.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 714.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.0, 319.8878470836647

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
835.0, 315.6487209084879

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
902.9531617649475, 183.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.28134907332355, 525.0

c43

c43

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
680.5207120456198, 294.60023958660497

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.4195317762593, 283.9917466839755

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.9645027097611, 258.93645805334324

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.8887969655509, 352.4149857154491

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 275.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.7294278030124, 242.326060730508

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0937859884835, 433.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.9975603804354, 116.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.0, 170.39152084838904

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.94028500029066, 173.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 108.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.9656235549245, 187.27236659569408

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.14115091028873, 181.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 104.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
607.3886525420016, 178.81509280259235

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 177.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 102.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
842.0, 525.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.9885438102705, 150.89361726572216

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.0, 153.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 100.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.0, 133.25424595843361

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 129.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.0, 176.64768602070043

c65

c65

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
174.0, 183.77437967055153

c66

c66

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
174.0, 176.37416858073559

c67

c67

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
174.0, 150.0139379874883

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
174.0, 123.63143143735442

c69

c69

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
653.0, 608.6660723187076

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.94922374651964, 533.8999121222475

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
229.0, 211.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.0, 310.9721097541357

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 488.0

c73

c73

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
338.0, 432.33424958260457

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.0564491633347, 275.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.0, 246.33876008876862

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 417.1493915422654

c77

c77

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
346.0, 493.2219089141281

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.38395521408626, 341.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 605.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 273.6160181389667

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 480.0

c81

c81

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
346.0, 457.9633749357631

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.38278102646, 212.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.0, 231.56072828925915

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 453.21281292078095

c85

c85

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
345.0, 370.7632240917811

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.2789380745741, 175.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 256.6323274781849

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 358.3688349057351

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
639.0, 672.7354436625493

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.3090554610931, 192.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.0, 203.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.9855816161193, 256.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 264.12954204696723

c93

c93

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
394.2229224214463, 197.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
408.43845290457017, 270.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0, 245.3708512106194

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.0, 343.17995340238167

c97

c97

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
445.0, 197.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.7862887385181, 339.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back