1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/10534111.csml convertedTime:2009.07.01.12:19

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Differential responses of human monocytes and macrophages to IL-4 and IL-13.
Authors Hart PH, Bonder CS, Balogh J, Dickensheets HL, Donnelly RP, Finlay-Jones JJ.
Affiliation Department of Microbiology & Infectious Diseases, School of Medicine, FlindersUniversity of South Australia, Adelaide, Australia.
Abstract The primary interleukin-4 (IL-4) receptor complex on monocytes (type I IL-4receptor) includes the 140-kDa alpha chain (IL-4R alpha) and the IL-2 receptorgamma chain, gamma(c), which heterodimerize for intracellular signaling,resulting in suppression of lipopolysaccharide (LPS)-inducible inflammatorymediator production. The activity of IL-13 on human monocytes is very similar tothat of IL-4 because the predominant signaling chain (IL-4R alpha) is common toboth receptors. In fact, IL-4R alpha with IL-13R alpha1 is designated both as anIL-13 receptor and the type II IL-4 receptor. When the anti-inflammatoryactivities of IL-4 and IL-13 were investigated on synovial fluid macrophages andcompared with the responses by monocytes isolated from the patients at the sametime as joint drainage, the response profiles differed with some responsessimilar in the two cell populations, others reduced on the inflammatory cells.Similar differences were recorded in the response profiles to IL-4 and IL-13 bymonocytes and monocytes cultured for 7 days in macrophage colony-stimulatingfactor (M-CSF) or granulocyte-macrophage CSF (GM-CSF) (monocyte-derivedmacrophages, MDMac). MDMac have reduced gamma(c) mRNA levels and reducedexpression of the functional 64-kDa gamma(c). There was a similar loss of IL-13Ralpha1 mRNA on monocyte differentiation. In turn, there was a significantreduction in the ability of IL-4 and IL-13 to activate STAT6. These findingssuggest that different functional responses to IL-4 and IL-13 by human monocytesand macrophages may result from reduced expression of gamma(c) and IL-13Ralpha1.
PMID 10534111
Model Abstract

Entity

G010329:TNF-alpha G010389:IL-1beta G011345:IL10 MO000000090:GM-CSFR MO000000099:GM-CSF MO000000145:Jak1 MO000007321:IL-13 MO000013130:STAT6 MO000016656:STATs MO000016665:IFNgamma MO000016882:LPS MO000017053:IL-4 MO000017058:IL-4Ralpha MO000017215:IL-2Rbeta MO000017247:IL-10 MO000017252:IL-10R MO000019394:TLR4 MO000034134:IL-4:IL-4Ralpha MO000045621:IL-13Ralpha1 MO000045622:IL-13Ralpha2 e1: e10: e11:LPS:TLR4 e12:IL-2Rgamma:IL-2Rbeta e13:t-PA e14:IL-6 e15:PGE2 e16:t-PA e17:IL-13:IL-13Ralpha1 e18:IL-13:IL-13Ralpha1:IL-4Ralpha e19:IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1:STAT6 e2: e20:IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1 e21:IL-4:IL-4Ralpha:IL-13Ralpha1 e22:Il-13:IL-13Ralpha2 e23:STAT6{active} e24:IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1 e25:IFNgammaR e26:IFNgamma:receptor e27:GM-CSF:GM-CSFR e28:IL-10:IL-10R e29:STATs e3: e30:IL-12 e32:IL-4{mutant} e33:IL-4{mutant}:IL-4Ralpha e34:Neutralizing antibiody e4: e5:IL-2Rgamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL4:IL-4Ralpha:IL-2Rgamma e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p4 p5 p6 p7 p8 p9
Model Detail
539.0, 771.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p2 p24 p26 p27

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
599.0, 915.0
33.5, 33.5

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p3 p29 p30

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
541.0, 869.0
29.5, 29.5

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
976.0, 452.0
31.0, 31.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
1088.0, 432.0
31.5, 31.5

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
285.0, 241.0
29.0, 29.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
29.0, 389.0
30.0, 30.0

IL-13

--

MO000007321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p15

true true true true

csml-variable:Double

m836

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000007321

--

Go back
361.0, 229.0
29.0, 29.0

STAT6

--

MO000013130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p17

true true true true

csml-variable:Double

m1368

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013130

--

Go back
645.0, 389.0
29.5, 29.5

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22 p23

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
1084.0, 240.0
31.0, 31.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
51.0, 967.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
35.0, 595.0
25.0, 25.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
186.0, 570.0
27.0, 27.0

IL-4Ralpha

--

MO000017058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p11 p28

true true true true

csml-variable:Double

m1951

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000017058

--

Go back
186.0, 870.0
27.0, 27.0

IL-2Rbeta

--

MO000017215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m2081

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000017215

--

Go back
1107.0, 567.0
26.5, 26.5

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
979.0, 679.0
26.5, 26.5

IL-10R

--

MO000017252

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m2108

10

false

infinite

0

unit false false false
TRANSPATHMO000017252

--

Go back
186.0, 1010.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
184.0, 652.0
31.5, 31.5

IL-4:IL-4Ralpha

--

MO000034134

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m12691

10

false

infinite

0

unit false false false
TRANSPATHMO000034134

--

Go back
185.0, 301.0
30.0, 30.0

IL-13Ralpha1

--

MO000045621

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p14

true true true true

csml-variable:Double

m23256

10

false

infinite

0

unit false false false
InterProIPR003532
TRANSPATHMO000045621

--

Go back
830.0, 138.0
28.0, 28.0

IL-13Ralpha2

--

MO000045622

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m23257

10

false

infinite

0

unit false false false
InterProIPR003532
TRANSPATHMO000045622

--

Go back
167.75, 109.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
196.19701637229, 192.06840239569328
790.6110105209949, 1112.1673841860556

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
187.5, 1095.0
25.0, 50.0

LPS:TLR4

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
186.5, 947.0
26.11992983994738, 50.55470291602718

IL-2Rgamma:IL-2Rbeta

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
488.0, 651.0
48.944636678200695, 26.103806228373703

t-PA

--

e13

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
542.0, 986.0
52.0, 28.0

IL-6

--

e14

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
545.0, 439.0
46.67788057190917, 26.450798990748527

PGE2

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
90.0, 594.5
35.68, 26.76

t-PA

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

p9

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
185.5, 380.0
28.56676167507126, 55.29050646787985

IL-13:IL-13Ralpha1

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
183.5, 217.0
33.51458983299688, 46.76454395301891

IL-13:IL-13Ralpha1:IL-4Ralpha

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
498.0, 118.0
36.0, 60.0

IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1:STAT6

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
167.75, 109.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
232.0, 117.0
31.852941176470587, 53.08823529411765

IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
698.5, 119.0
35.4321893925491, 49.44026426867316

IL-4:IL-4Ralpha:IL-13Ralpha1

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
943.5, 124.0
24.699408024556018, 47.80530585397939

Il-13:IL-13Ralpha2

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
677.0, 297.0
29.0, 29.0

STAT6{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p17

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013130

--

Go back
976.0, 213.0
31.852941176470587, 53.08823529411765

IL-13:IL-13Ralpha1:IL-4Ralpha:JAK1

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
976.5, 293.0
30.386643233743406, 46.74868189806679

IFNgammaR

--

e25

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p18

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
977.5, 371.0
29.55229116421837, 57.197982898487176

IFNgamma:receptor

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
976.5, 514.0
31.0, 60.0

GM-CSF:GM-CSFR

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
979.5, 595.0
25.43345757509318, 49.22604691953519

IL-10:IL-10R

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
793.0, 365.0
29.5, 29.5

STATs

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p22 p23

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
184.87518862352903, 127.12209663264667
822.0090539293949, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
628.0, 775.0
48.840830449826996, 26.048442906574397

IL-12

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
83.0, 535.0
25.0, 25.0

IL-4{mutant}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
184.0, 468.0
31.5, 31.5

IL-4{mutant}:IL-4Ralpha

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000034134

--

Go back
1093.0, 859.0
22.769230769230766, 34.153846153846146

Neutralizing antibiody

--

e34

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
216.55678757705795, 157.09117672382237
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
184.5, 717.0
30.066783831282947, 46.256590509666076

IL-2Rgamma

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p8

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
287.2634214842695, 569.6976032180354
561.5643131419606, 509.2771331473645

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
347.9165502780006, 581.7667309011314
328.3634903660624, 493.59097914898564

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
294.5836266835129, 576.4949366173332
546.923902743474, 495.6824663487694

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
295.6293702834047, 577.5406802172247
544.8324155436895, 493.59097914898564

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
287.2634214842695, 569.6976032180354
561.5643131419606, 509.2771331473645

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
287.2634214842695, 569.6976032180354
561.5643131419606, 509.2771331473645

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
295.6293702834047, 577.5406802172247
544.8324155436895, 493.59097914898564

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
697.1949126419012, 778.8463231964195
35.083452767703385, 31.759757242342044

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
605.1694758514133, 925.2504271812882
99.34564198973227, 89.9339495907051

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
287.2634214842695, 569.6976032180354
561.5643131419606, 509.2771331473645

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
189.5, 791.0
36.22921636997614, 50.55239493485043

IL4:IL-4Ralpha:IL-2Rgamma

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
419.62097038692673, 796.0161529971292
17.783916665122785, 8.56262654246653

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
419.02711507065135, 770.4803743972838
60.870169918237146, 109.5663058528268

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
444.5628936704977, 841.7430123503423
9.50168506040774, 9.501685060407741

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
187.2713617658909, 227.08192958709262
775.5710670584031, 1098.9641688207626

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
228.18784777808088, 130.22875497377345
752.3691376390469, 1092.4399878518961

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
214.78709657132242, 155.27470425543433
762.0920793316639, 1097.0541261005437

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
52.5, 1040.5
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 10534111 LPS binds its receptor TLR4.

Go back
47.0, 303.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m23256*m836*0.1

nodelay

--

true

0

false

PMID: 10534111, 8910586, 9013879 The IL-13Ra1 chain has weak IL-13 binding capacity on its own but binds IL-13 strongly on complexing with the IL-4Ra chain [26, 27].

Go back
82.0, 414.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m17*m1951*0.1

nodelay

--

true

0

false

PMID: 10534111, 8910586, 9013879 The IL-13Ra1 chain has weak IL-13 binding capacity on its own but binds IL-13 strongly on complexing with the IL-4Ra chain [26, 27].

Go back
77.0, 129.0
29.0, 29.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 10534111 For IL-13, the second bound receptor chain (IL-4Ra) functions to recruit JAK1 to the receptor complex, and to provide a docking site for STAT6 on its intracellular domain and thus provides a mechanism by which the biological effects of IL-4 and IL-13 on monocytes are very similar.

Go back
311.0, 31.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m20*m1368*0.1

nodelay

--

true

0

false

PMID: 10534111 For IL-13, the second bound receptor chain (IL-4Ra) functions to recruit JAK1 to the receptor complex, and to provide a docking site for STAT6 on its intracellular domain and thus provides a mechanism by which the biological effects of IL-4 and IL-13 on monocytes are very similar.

Go back
67.0, 239.0
25.0, 25.0

p14

p14

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m12691*m23256*0.1

nodelay

--

true

0

false

PMID: 10534111, 9573026 There is strong evidence particularly on non-hematopoietic cells that the IL-4Ra chain on binding to IL-4 can heterodimerize with the IL-13Ra1 chain forming the type II IL-4 receptor [28].

Go back
763.0, 35.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m836*m23257*0.1

nodelay

--

true

0

false

PMID: 10534111, 8663118 A second IL-13-specific receptor chain, IL-13Ra2, has been cloned from a human renal carcinoma cell line and binds IL-13 with much higher affinity [29].

Go back
579.0, 227.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 The loss of IL-4- and IL-13-induced STAT6 activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered with monocyte culture [16, 17].

Go back
445.0, 269.0
29.0, 29.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m6*m1368*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 The loss of IL-4- and IL-13-induced STAT6 activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered with monocyte culture [16, 17].

Go back
1087.0, 347.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m1639*m25*0.1

nodelay

--

true

0

false

PMID: 10534111 IFN-gamma binds its corresponding receptor.

Go back
1072.0, 532.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 10534111 GM-CSF binds its corresponding receptor.

Go back
467.5, 807.5
25.0, 25.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c21 : 1
stoichiometry:c8 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 9558115, 10427971, 9558115, 10427971 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level. Furthermore, in kinetic studies of mRNA levels for gc and IL-13Ra1 with increasing time of culture for monocytes, as mRNA levels were reduced so too was the ability of IL-4 and IL-13 to suppress LPS-induced TNF-a production [16, 17].

Go back
1061.0, 625.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m2103*m2108*0.1

nodelay

--

true

0

false

PMID: 10534111 IL-10 binds its corresponding receptor.

Go back
838.0, 562.0
27.0, 27.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m1633*m26*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 The loss of IL-4- and IL-13-induced STAT6 activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered with monocyte culture [16, 17].

Go back
694.0, 522.0
27.0, 27.0

p21

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m27*m1633*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 The loss of IL-4- and IL-13-induced STAT6 activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered with monocyte culture [16, 17].

Go back
786.0, 602.0
27.0, 27.0

p21

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m1633*m28*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 The loss of IL-4- and IL-13-induced STAT6 activation with monocyte differentiation was unique because STATs activated by IFN-g, GM-CSF, and IL-10 were not altered with monocyte culture [16, 17].

Go back
431.0, 747.0
25.0, 25.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 9558115, 10427971 Furthermore, in kinetic studies of mRNA levels for gc and IL-13Ra1 with increasing time of culture for monocytes, as mRNA levels were reduced so too was the ability of IL-4 and IL-13 to suppress LPS-induced TNF-a production [16, 17].

Go back
642.0, 638.0
27.0, 27.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c74 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10534111, 10227996 It was recently shown that IL-4 could regulate TNF-a and IL-12 production by IFN-g-activated murine bone marrow-derived macrophages from STAT6-/- mice [31].

Go back
706.0, 842.0
27.0, 27.0

p25

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 10534111, 10227996 It was recently shown that IL-4 could regulate TNF-a and IL-12 production by IFN-g-activated murine bone marrow-derived macrophages from STAT6-/- mice [31].

Go back
708.0, 884.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c93 : 1
stoichiometry:c83 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111 First, a neutralizing antibody to gc blocked IL-4 regulation of LPSinduced TNF-a, but not IL-1b, production.

Go back
55.0, 475.0
25.0, 25.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m32*m1951*0.1

nodelay

--

true

0

false

PMID: 10534111 Second, a mutant IL-4 molecule that was able to bind the IL-4Ra chain but not gc suppressed LPS-induced monocyte IL-1b, but not TNF-a, production.

Go back
574.0, 622.0
27.0, 27.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111 Second, a mutant IL-4 molecule that was able to bind the IL-4Ra chain but not gc suppressed LPS-induced monocyte IL-1b, but not TNF-a, production.

Go back
475.5, 931.5
25.0, 25.0

p2

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c23 : 1
stoichiometry:c9 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level.

Go back
699.0, 935.0
25.0, 25.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c90 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 10427971 From studies using an antibody to the IL-4Ra chain, we know that this chain is a component of the receptor by which IL-4 and IL-13 signal suppression of LPS-induced IL-1b production by MDMac [17].

Go back
465.0, 481.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 9558115, 10427971, 9558115, 10427971 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level.

Go back
503.5, 1031.5
25.0, 25.0

p2

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c24 : 1
stoichiometry:c10 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level.

Go back
463.5, 871.5
25.0, 25.0

p2

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c22 : 1
stoichiometry:c82 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level.

Go back
61.0, 657.0
22.0, 22.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m1947*m1951*0.1

nodelay

--

true

0

false

PMID: 10534111, 9573026 It is believed that a site within the A/C helices of IL-4 first binds the IL-4Ra chain with high affinity. A site located near the end of helix D then binds gc, creating an active receptor dimer; mutations of the tyrosine at position 124 greatly reduces this interaction. There is strong evidence particularly on non-hematopoietic cells that the IL-4Ra chain on binding to IL-4 can heterodimerize with the IL-13Ra1 chain forming the type II IL-4 receptor [28].

Go back
59.0, 715.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m12691*m5*0.1

nodelay

--

true

0

false

PMID: 10534111 It is believed that a site within the A/C helices of IL-4 first binds the IL-4Ra chain with high affinity. A site located near the end of helix D then binds gc, creating an active receptor dimer; mutations of the tyrosine at position 124 greatly reduces this interaction.

Go back
59.0, 887.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m5*m2081*0.1

nodelay

--

true

0

false

PMID: 10534111, 7843245 Western blots of gc on monocytes suggested proteins of 58 and 64 kDa but only the 64 kDa protein could associate with the IL-2Rb chain [23].

Go back
327.0, 583.0
26.0, 26.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c49 : 1
stoichiometry:c27 : 1

m13*m11*0.1

nodelay

--

true

0

false

PMID: 10534111, 2786204, 2120129, 2785566, 2114443 IL-4 inhibited the production of lipopolysaccharide (LPS)-stimulated tumor necrosis factor a (TNF-a), IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2) [1?4] by monocytes and this regulation occurred for the peptides, at least in part, at the mRNA level.

Go back
64.0, 993.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 1019.2494297193983

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 518.2991090498533

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
53.0, 620.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
89.6762792031115, 593.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.0, 668.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
91.24018961399867, 675.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.96107411703854, 729.7882251601028

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.0, 736.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.01535448495794, 759.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.93580600379796, 886.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.83065680517765, 1027.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.0, 907.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 816.0

c21

c21

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
226.0, 821.0

c22

c22

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
226.0, 824.0

c23

c23

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
226.0, 829.0

c24

c24

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
360.44668221238396, 603.9235122759729

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
223.0, 612.4316342703058

c26

c26

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
133.99011759678103, 597.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
80.0, 316.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.0, 335.8730161395608

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
76.0, 1058.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
72.0, 324.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.85239189664765, 411.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
109.43760156980183, 447.6564023547028

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 270.9998517408214

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
111.99197249992305, 161.30059105762422

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 152.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
106.0, 144.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 62.36563410841816

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0139091975541, 63.74236202615242

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 50.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 838.856254368964

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
85.21869194279323, 271.6861828018194

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.04620019048606, 261.7882796723043

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
92.0, 148.33836440691726

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
59.0, 57.503967079858405

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.3779949038616, 66.69575691178837

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 55.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 170.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 249.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 240.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 616.7282936501118

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
213.0, 956.1579266211148

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
220.0, 305.2328873030443

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 251.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 286.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 271.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 322.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.5210885212998, 365.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1088.6132233653639, 464.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 480.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0, 544.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.2542459584336, 594.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.0, 1048.8710270828924

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 648.6274302184635

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1012.8499905641687, 624.5419624322474

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 417.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.9922645619256, 418.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.7749876778742, 402.80060374223655

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.9960966086966, 536.2498780190218

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.0, 419.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.0, 401.720817431785

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 419.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 402.99542971695735

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 900.1903339341835

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.9977061753588, 616.1915618245595

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
213.0, 778.6284599055257

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 763.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 264.0

c73

c73

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
652.2907169448572, 665.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.4074572589927, 411.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
226.0, 658.380730205743

c76

c76

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
732.1063000783993, 424.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.3612370850286, 793.1324413127782

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 817.0

c79

c79

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
493.0, 794.5777087639997

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 904.1746136452168

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
226.0, 819.0

c81

c81

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
489.0, 884.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.6635626439612, 797.4268423159183

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
77.32607808214236, 507.2757958046864

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
86.4725281567466, 501.701742151599

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.0, 485.2306732790395

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 655.2402547094721

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 490.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
589.0, 649.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 934.7316151395659

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.8911513906571, 936.3151918984429

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 954.5578791025914

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
217.0, 264.0

c92

c92

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
734.9950642466747, 877.0

c93

c93

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
495.0, 466.5777087639997

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 514.049875995313

c95

c95

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back