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PMID: 11090938, 8717514, 7516408
Interaction of CD28 on T lymphocytes with their ligands B7.1 and B7.2 (CD80 and CD86) on monocytes are known to deliver such ostimulatory signals.
We therefore investigated the role of these costimulatory signals during LPS-induced T-lymphocyte proliferation using soluble CTLA-4Ig, which blocks B7:CD28 interactions.
PMID: 11090938
We found that these LPS-pulsed monocytes could stimulate human T lymphocytes, suggesting that one function of accessory monocytes during activation of T lymphocytes by LPS was to present costimulatory signal(s).
Indirect
Indirect
PMID: 11090938
the interaction of LPSprimed monocytes with T cells was not MHC-restricted.
This interaction was found to be MHC-unrestricted, but strongly dependent on costimulatory signals provided by B7:CD28 interactions.
LPS-primed monocytes provide costimulatory signals through CD28 and/or CTLA-4/B7 interactions.
PMID:11090938
LPS-primed monocytes provide costimulatory signals through CD28 and/or CTLA-4/B7 interactions.
Indirect
PMID: 11090938
Human MNC, stimulated with LPS, not only expressed mRNA for the monokines interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a), but also mRNA for the T helper 1 (Th1)-cytokines interferongamma (IFN-g) and IL-2.
Indirect
PMID: 11090938
Human MNC, stimulated with LPS, not only expressed mRNA for the monokines interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a), but also mRNA for the T helper 1 (Th1)-cytokines interferongamma (IFN-g) and IL-2.
Indirect
PMID: 11090938
Human MNC, stimulated with LPS, not only expressed mRNA for the monokines interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a), but also mRNA for the T helper 1 (Th1)-cytokines interferongamma (IFN-g) and IL-2.
Indirect
PMID: 11090938
Human MNC, stimulated with LPS, not only expressed mRNA for the monokines interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a), but also mRNA for the T helper 1 (Th1)-cytokines interferongamma (IFN-g) and IL-2.
Indirect
PMID: 11090938
Human MNC, stimulated with LPS, not only expressed mRNA for the monokines interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a), but also mRNA for the T helper 1 (Th1)-cytokines interferongamma (IFN-g) and IL-2.