_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e12
_enti_e67
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e59
_enti_e53
_enti_e50
_enti_e56
_enti_e51
_enti_e54
_enti_e52
_enti_e58
_enti_e57
_enti_e61
_enti_e60
_enti_e62
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g3
p1_propro_p1
PMID:11367531
Prostanoids are generated enzymatically from arachidonic
acid released from phospholipids in the cellular
membranes.
c1 cso30:c:InputProcess connector
c2 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 11367531, 9272704, 9464523
Receptors for C5a C5aRrCD88. have been
cloned in various species including rat,man
and mouse.
c6 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 11367531
LPS binds its receptor TLR.
c11 cso30:c:InputProcess connector
c12 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 11367531, 2170121
LPS is known to induce the synthesis of these
proinflammatory cytokines (IL-6, Il-1beta and TNF-alpha) in KC
c14 cso30:c:InputAssociation connector
c20 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p6_propro_p7
PMID: 11367531, 2170121
LPS is known to induce the synthesis of these
proinflammatory cytokines (IL-6, Il-1beta and TNF-alpha) in KC
c15 cso30:c:InputAssociation connector
c21 cso30:c:InputAssociation connector
c18 cso30:c:OutputProcess connector
p6_propro_p8
PMID: 11367531, 2170121
LPS is known to induce the synthesis of these
proinflammatory cytokines (IL-6, Il-1beta and TNF-alpha) in KC
c16 cso30:c:InputAssociation connector
c22 cso30:c:InputAssociation connector
c19 cso30:c:OutputProcess connector
p9_propro_p9
PMID:11367531
In isolated KC, C5a alone did not induce IL-6 synthesis,
but synergistically enhanced the LPS-dependent
IL-6 synthesis both on the mRNA and on the
protein level, again demonstrating the different
roles of distinct inflammatory mediators in the regulation
of liver-specific effector functions.
c24 cso30:c:InputAssociation connector
c25 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p10_propro_p10
PMID:11367531, 3116090, 2208809
In isolated KC, C5a alone did not induce IL-6 synthesis,
but synergistically enhanced the LPS-dependent
IL-6 synthesis both on the mRNA and on the
protein level, again demonstrating the different
roles of distinct inflammatory mediators in the regulation
of liver-specific effector functions.
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c26 cso30:c:InputAssociation connector
c28 cso30:c:InputAssociation connector
c29 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 11367531
In contrast
to its role in IL-6 synthesis, C5a induced the expression
of both IL-1b- and TNFa-mRNA but not of
IL-1b- and TNFa-protein.
c32 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 11367531
In contrast
to its role in IL-6 synthesis, C5a induced the expression
of both IL-1b- and TNFa-mRNA but not of
IL-1b- and TNFa-protein.
c33 cso30:c:InputAssociation connector
c31 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 11367531,3116090, 2208809
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c34 cso30:c:InputAssociation connector
c39 cso30:c:InputAssociation connector
c35 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 11367531,3116090, 2208809
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c36 cso30:c:InputAssociation connector
c38 cso30:c:InputAssociation connector
c37 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 11367531,3116090, 2208809
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c40 cso30:c:InputAssociation connector
c41 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 11367531,3116090, 2208809
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c43 cso30:c:InputAssociation connector
c44 cso30:c:InputAssociation connector
c45 cso30:c:InputAssociation connector
c46 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 11367531,3116090, 2208809
In monocytes
and macrophages of peripheral blood C5a has also
been described to induce IL-6-, IL-1b- and TNFarelease
either alone or in combination with
other proinflammatory agents such as LPS.
c47 cso30:c:InputAssociation connector
c48 cso30:c:InputAssociation connector
c146 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 11367531, 10422197
While type-1
acute phase proteins are mainly induced by IL-1b
and TNFa, type-2 acute phase proteins are predominantly induced by IL-6
c51 cso30:c:InputAssociation connector
c57 cso30:c:InputAssociation connector
c53 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 11367531, 10422197
While type-1
acute phase proteins are mainly induced by IL-1b
and TNFa, type-2 acute phase proteins are predominantly induced by IL-6
c50 cso30:c:InputAssociation connector
c61 cso30:c:InputAssociation connector
c52 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 11367531
TNF-alpha binds its corresponding receptor
c54 cso30:c:InputProcess connector
c55 cso30:c:InputProcess connector
c56 cso30:c:OutputProcess connector
p21_propro_p21
PMID:11367531
IL-1beta binds its corresponding receptor.
c58 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 11367531
IL-6 binds its respective receptor.
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 11367531, 10422197
While type-1
acute phase proteins are mainly induced by IL-1b
and TNFa, type-2 acute phase proteins are predominantly induced by IL-6
c65 cso30:c:InputAssociation connector
c67 cso30:c:InputAssociation connector
c66 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 11367531
How- 2
ever, the conditioned media of KC, which had been
treated with C5a and LPS, enhanced the expression
of a -macroglobulin mRNA significantly more than 2
conditioned media of KC, which had been treated
with LPS alone
c69 cso30:c:InputAssociation connector
c70 cso30:c:InputAssociation connector
c68 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 11367531
How- 2
ever, the conditioned media of KC, which had been
treated with C5a and LPS, enhanced the expression
of a -macroglobulin mRNA significantly more than 2
conditioned media of KC, which had been treated
with LPS alone
c71 cso30:c:InputAssociation connector
c72 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 11367531, 7836770, 9464274
The intraperitoneal injection of lipopolysaccharide,
a major trigger of inflammation, increased C5aR
mRNA expression in various organs of mouse
and ratincluding the liver.
c73 cso30:c:InputAssociation connector
c74 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 11367531, 10799912
It could be shown that in vivo treatment of rats
with IL-6 led to a time-dependent expression of
C5aR mRNA with a maximum between 4 and 8 h
and of C5aR protein 810 h after IL-6 treatment
c75 cso30:c:InputAssociation connector
c76 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 11367531, 10799912
It could be shown that in vivo treatment of rats
with IL-6 led to a time-dependent expression of
C5aR mRNA with a maximum between 4 and 8 h
and of C5aR protein 810 h after IL-6 treatment
c77 cso30:c:InputAssociation connector
c79 cso30:c:InputAssociation connector
c78 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 11367531, 7556629, 9742932
The de novo expressed receptors were
functional, since in HC from IL-6-treated rats C5a
directly activated glycogen phosphorylase; in contrast
it acted indirectly on HC from control animals
via prostanoids released from C5aR expressing KC or HSC.
c81 cso30:c:InputProcess connector
c83 cso30:c:InputAssociation connector
c80 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 11367531, 7541417, 7540650
This is supported by the
findings that, in the C5aR expressing tumor cells,
HepG2 C5a induced the acute phase proteins a -an- 1
titrypsin and a -antichymotrypsin and repressed the 1
negative acute phase proteins albumin and transferrin
c84 cso30:c:InputAssociation connector
c92 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p30_propro_p31
PMID: 11367531, 7541417, 7540650
This is supported by the
findings that, in the C5aR expressing tumor cells,
HepG2 C5a induced the acute phase proteins a -an- 1
titrypsin and a -antichymotrypsin and repressed the 1
negative acute phase proteins albumin and transferrin
c85 cso30:c:InputAssociation connector
c93 cso30:c:InputAssociation connector
c89 cso30:c:OutputProcess connector
p30_propro_p32
PMID: 11367531, 7541417, 7540650
This is supported by the
findings that, in the C5aR expressing tumor cells,
HepG2 C5a induced the acute phase proteins a -an- 1
titrypsin and a -antichymotrypsin and repressed the 1
negative acute phase proteins albumin and transferrin
c86 cso30:c:InputAssociation connector
c94 cso30:c:InputInhibitor connector
c91 cso30:c:OutputProcess connector
p30_propro_p33
PMID: 11367531, 7541417, 7540650
This is supported by the
findings that, in the C5aR expressing tumor cells,
HepG2 C5a induced the acute phase proteins a -an- 1
titrypsin and a -antichymotrypsin and repressed the 1
negative acute phase proteins albumin and transferrin
c87 cso30:c:InputAssociation connector
c95 cso30:c:InputInhibitor connector
c90 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 11367531
The anaphylatoxin C5a is generated by limited proteolysis from the N-terminus of the alpha-chain of the fifth component of complement, C5
c96 cso30:c:InputProcess connector
c97 cso30:c:InputAssociation connector
c98 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 11367531
The C5aR is a G-protein-coupled receptor with seven transmembrane segments (seven TMS receptors) belonging to the rhodopsin family and acting via an increase in intracellular inositol-1,4,5-triphosphate (IP3) and intracellular Ca2+.
c101 cso30:c:InputAssociation connector
c103 cso30:c:OutputProcess connector
p36_propro_p37
PMID: 11367531
The C5aR is a G-protein-coupled receptor with seven transmembrane segments (seven TMS receptors) belonging to the rhodopsin family and acting via an increase in intracellular inositol-1,4,5-triphosphate (IP3) and intracellular Ca2+.
c102 cso30:c:InputAssociation connector
c104 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC. After stimulation with rrC5a, KC not only released predominantly PGD2 and TXA2, but also PGF2α and PGE2.
c109 cso30:c:InputProcess connector
c100 cso30:c:InputAssociation connector
c110 cso30:c:OutputProcess connector
p39_propro_p2
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC. After stimulation with rrC5a, KC not only released predominantly PGD2 and TXA2, but also PGF2α and PGE2.
c3 cso30:c:InputProcess connector
c105 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p39_propro_p40
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC. After stimulation with rrC5a, KC not only released predominantly PGD2 and TXA2, but also PGF2α and PGE2.
c4 cso30:c:InputProcess connector
c106 cso30:c:InputAssociation connector
c108 cso30:c:OutputProcess connector
p39_propro_p41
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC. After stimulation with rrC5a, KC not only released predominantly PGD2 and TXA2, but also PGF2α and PGE2.
c5 cso30:c:InputProcess connector
c107 cso30:c:InputAssociation connector
c99 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC.
c9 cso30:c:InputProcess connector
c114 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p4_propro_p35
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC.
c111 cso30:c:InputProcess connector
c115 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
p4_propro_p38
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC.
c112 cso30:c:InputProcess connector
c116 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p4_propro_p42
PMID: 11367531, 8244278, 7556629
Native human C3a [43] as well as rrC5a [44] rapidly induced prostanoid release from KC.
c113 cso30:c:InputProcess connector
c117 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 11367531, 8281925
After the application of zymosan, prostanoid release was initiated as fast as after stimulation with rrC5a, but the maximum was only reached after 1030 min [46 and 47].
c122 cso30:c:InputProcess connector
c126 cso30:c:InputAssociation connector
c133 cso30:c:OutputProcess connector
p43_propro_p44
PMID: 11367531, 8281925
After the application of zymosan, prostanoid release was initiated as fast as after stimulation with rrC5a, but the maximum was only reached after 1030 min [46 and 47].
c123 cso30:c:InputProcess connector
c127 cso30:c:InputAssociation connector
c132 cso30:c:OutputProcess connector
p43_propro_p45
PMID: 11367531, 8281925
After the application of zymosan, prostanoid release was initiated as fast as after stimulation with rrC5a, but the maximum was only reached after 1030 min [46 and 47].
c124 cso30:c:InputProcess connector
c128 cso30:c:InputAssociation connector
c131 cso30:c:OutputProcess connector
p43_propro_p46
PMID: 11367531, 8281925
After the application of zymosan, prostanoid release was initiated as fast as after stimulation with rrC5a, but the maximum was only reached after 1030 min [46 and 47].
c125 cso30:c:InputProcess connector
c129 cso30:c:InputAssociation connector
c130 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 11357531, 2390987
In contrast, prostanoid release induced by LPS was measurable only after 35 h [46 and 48].
c134 cso30:c:InputProcess connector
c138 cso30:c:InputAssociation connector
c142 cso30:c:OutputProcess connector
p47_propro_p48
PMID: 11357531, 2390987
In contrast, prostanoid release induced by LPS was measurable only after 35 h [46 and 48].
c135 cso30:c:InputProcess connector
c139 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p47_propro_p49
PMID: 11357531, 2390987
In contrast, prostanoid release induced by LPS was measurable only after 35 h [46 and 48].
c136 cso30:c:InputProcess connector
c140 cso30:c:InputAssociation connector
c144 cso30:c:OutputProcess connector
p47_propro_p50
PMID: 11357531, 2390987
In contrast, prostanoid release induced by LPS was measurable only after 35 h [46 and 48].
c137 cso30:c:InputProcess connector
c141 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
Phospholipids_enti_e5
Phospholipids
arachidonic acid_enti_e6
arachidonic acid
PGD2_enti_e11
PGD2
C5a{Gly}_enti_e13
C5a{Gly}
C5aR_enti_e14
C5aR
C5a{Gly}:C5aR_enti_e15
C5a{Gly}:C5aR
LPS_enti_e16
LPS
TLR receptor_enti_e17
TLR receptor
LPS:TLR_enti_e18
LPS:TLR
IL-6_enti_e19
IL-6
IL-1beta_enti_e20
IL-1beta
TNF-alpha_enti_e21
TNF-alpha
IL-6_enti_e22
IL-6
Il-1beta_enti_e23
Il-1beta
TNf-alpha_enti_e24
TNf-alpha
Type 2_enti_e25
Type 2
Type 1_enti_e26
Type 1
Type 1_enti_e27
Type 1
Type2_enti_e28
Type2
TNF-alpha receptor_enti_e29
TNF-alpha receptor
TNF-alpha:receptor_enti_e30
TNF-alpha:receptor
IL-1beta receptor_enti_e31
IL-1beta receptor
IL-1 beta:receptor_enti_e32
IL-1 beta:receptor
IL-6 receptor_enti_e33
IL-6 receptor
IL-6:receptor_enti_e34
IL-6:receptor
alpha2 macroglobulin_enti_e35
alpha2 macroglobulin
C5aR_enti_e36
C5aR
Glycogen phosphorylase_enti_e37
Glycogen phosphorylase
Glycogen phosphorylase{active}_enti_e38
Glycogen phosphorylase{active}
antitrypsin_enti_e39
antitrypsin
antichymotrypsin_enti_e40
antichymotrypsin
albumin_enti_e41
albumin
transferrin_enti_e42
transferrin
antitrypsin_enti_e43
antitrypsin
antichymotrypsin_enti_e44
antichymotrypsin
albumin_enti_e45
albumin
transferrin_enti_e46
transferrin
Calcium_enti_e63
Calcium
IP3_enti_e64
IP3
TXA2_enti_e66
TXA2
PGF2_enti_e68
PGF2
C5_enti_e47
C5
PGE2_enti_e48
PGE2
C3a_enti_e49
C3a
zymosan_enti_e65
zymosan