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PMID: 12005202, 7503988
Upon binding of G-CSF to its receptor, various cellular
proteins including the receptor itself are tyrosine phosphorylated
PMID: 12005202, 7512720
JAK1 is associated constitutively with the G-CSF
receptor and becomes activated by the binding of G-CSF to
the receptor [96, 103].
PMID: 12005202, 7512720
JAK1 is associated constitutively with the G-CSF
receptor and becomes activated by the binding of G-CSF to
the receptor [96, 103].
Indirect
PMID: 12005202, 7522448, 8977235, 9015216
Also the kinases JAK2 and TYK2 are
activated
Indirect
PMID: 12005202, 7522448, 8977235, 9015216
Also the kinases JAK2 and TYK2 are
activated
PMID: 12005202
G-CSF
induces the dimerization of the receptor, which then activates
JAK kinases through its membrane-proximal Box 1 and Box
2 region.
PMID: 12005202, 8547634
The activated JAK kinases tyrosine-phosphorylate
Tyr703 of the G-CSF receptor, to which STAT 3 is recruited
through its Src-homolog-2 (SH2) region [101].
PMID: 12005202, 8547634
The activated JAK kinases tyrosine-phosphorylate
Tyr703 of the G-CSF receptor, to which STAT 3 is recruited
through its Src-homolog-2 (SH2) region [101].
PMID: 12005202
JAK kinases
then phosphorylate STAT 3 bound to the receptor.
PMID: 12005202
The phosphorylated STAT 3 releases from the receptor by forming a
homodimer or heterodimer with STAT 1 and translocates to
the nucleus [96].
PMID: 12005202
STAT 3 releases from the receptor by forming a
homodimer or heterodimer with STAT 1 and translocates to
the nucleus [96].
PMID: 12005202
STAT 3 releases from the receptor by forming a
homodimer or heterodimer with STAT 1 and translocates to
the nucleus [96].
PMID: 12005202
The phosphorylated STAT3 released from the receptor by forming a homdimer or a hetrodimer with STAT1 translocates to the nucleus.
Indirect
PMID: 12005202, 9209832
The phosphorylated STAT dimerize and translocate into the
nucleus, where they induce the expression of specific genes
[96, 108].
PMID: 12005202, 8977235, 7521688
Among the STAT family members, G-CSF activates STAT1, STAT3 and STAT5.
PMID: 12005202
STAT 3 releases from the receptor by forming a
homodimer or heterodimer with STAT 1 and translocates to
the nucleus [96].
PMID: 12005202, 7579336, 8608222, 7509213, 9824671
The activation of ras seems to be mediated by various
molecules such as the Shc, Grb2 and Syp adaptors, and the
Vav guanine nucleotide exchanger, as these molecules are
phosphorylated by G-CSF in various cells responding to GCSF
[107, 110, 111] and bind directly to the G-CSF receptor
[112].
It is likely
that JAK family kinases, activated through the membraneproximal
region of the receptor, tyrosine-phosphorylate
Tyr764 on the receptor, to which adaptor molecules are recruited
which activate the ras/MAP kinase pathway
PMID: 12005202
It is likely
that JAK family kinases, activated through the membraneproximal
region of the receptor, tyrosine-phosphorylate
Tyr764 on the receptor, to which adaptor molecules are recruited
which activate the ras/MAP kinase pathway
PMID: 12005202
The activation of G-protein ras leads to the activation of the serine/threonine Kinase Raf-1.
Indirect
PMID: 12005202
The activation of the Gprotein
ras leads to the activation of the serine/threonine
kinase Raf-1 followed by sequential phosphorylation of the
tyrosine/threonine MAP kinase activator MEK (mitogenactivated/
extracellular signal kinase) and the serine/threonine
MAP kinases.
Indirect
PMID: 12005202
The activation of the Gprotein
ras leads to the activation of the serine/threonine
kinase Raf-1 followed by sequential phosphorylation of the
tyrosine/threonine MAP kinase activator MEK (mitogenactivated/
extracellular signal kinase) and the serine/threonine
MAP kinases.
PMID: 12005202, 8704229
Activated MAP kinases carry the signal
to the nucleus where they phosphorylate transcription factors
Indirect
PMID: 12005202, 8704229
Activated MAP kinases carry the signal
to the nucleus where they phosphorylate transcription factors
Indirect
PMID: 12005202, 8547634
The activated JAK kinases tyrosine-phosphorylate
Tyr703 of the G-CSF receptor, to which STAT 3 is recruited
through its Src-homolog-2 (SH2) region [101].
Indirect
PMID: 12005202, 8547634
The activated JAK kinases tyrosine-phosphorylate
Tyr703 of the G-CSF receptor, to which STAT 3 is recruited
through its Src-homolog-2 (SH2) region [101].
PMID: 12005202, 8977235, 7521688
Among the STAT family members, G-CSF activates STAt1, STAT3 and STAT5.
Indirect
PMID: 12005202
JAK kinases
then phosphorylate STAT 3 bound to the receptor.
Indirect
PMID: 12005202
JAK kinases
then phosphorylate STAT 3 bound to the receptor.
Indirect
PMID: 12005202, 9209832
The phosphorylated STAT dimerize and translocate into the
nucleus, where they induce the expression of specific genes
[96, 108].
PMID: 12005202, 7579336, 8608222, 7509213, 9824671
The activation of ras seems to be mediated by various
molecules such as the Shc, Grb2 and Syp adaptors, and the
Vav guanine nucleotide exchanger, as these molecules are
phosphorylated by G-CSF in various cells responding to GCSF
[107, 110, 111] and bind directly to the G-CSF receptor
[112].