1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/12005202.csml convertedTime:2009.07.01.10:40

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Molecular aspects of anti-inflammatory action of G-CSF.
Authors Boneberg EM, Hartung T.
Affiliation Biochemical Pharmacology, University of Konstanz, Germany.
Abstract Granulocyte colony-stimulating factor (G-CSF) is a cytokine which stimulates theproduction of neutrophils in the bone marrow and modulates cellular functions ofmature neutrophils. Besides neutrophils and their precursors, monocytes aredirect target cells of G-CSF action. G-CSF influences monocyte functions in ananti-inflammatory way: The stimulation of monocytes with G-CSF results in anattenuation of LPS-induced release of IL-1beta, TNF-alpha, IL-12 and IL-18.G-CSF exerts its biological functions on neutrophils and monocytes viamembrane-bound receptors. Seven different human G-CSF receptor isoforms havebeen described which are generated by alternative splicing. The physiologicroles of these isoforms and the expression pattern on various cell types arestill unknown. The signal transduction pathway of G-CSF receptors involves theactivation of JAK tyrosine kinases and STAT transcription factors and theras/mitogen-activated protein kinase pathway.
PMID 12005202
Model Abstract

Entity

e1: e10: e11:G-CSF receptor e12:JAK1 e13:JAK1:G-CSFreceptor e14:2JAK1:2receptor:2G-CSF e15:TYK2 e16:JAK2 e17:TYK2{active} e18:JAK2{active} e19:2JAK1{active}:2receptor:2G-CSF e2: e20:2JAK1{active}:2receptor{p}:2G-CSF e21:STAT3 e22:2JAK1{active}:2receptor {p}:2G-CSF:STAT3 e23:2JAK1{active}:2receptor{p}:2G-CSF:STAT3{p} e24:STAT3{p} e25:2STAT3{p} e26:Shc:GRB2:SOS e27:STAT1{active}:STAT3{p} e28:2STAT3{p} e29:STAT1{active}:STAT3{p} e3: e30:MRNA e31:STAT1 e32:STAT1{active} e33:STAT5 e34:STAT5{active} e35:2JAK1{active}:2receptor{p}:2G-CSF:Shc:GRB2:SOS:Vav:Syp e36:Ras e37:Ras{active} e38:Raf1 e39:Raf1{active} e4: e40:MEK e41:MEK{p} e42:MAPKs{p} e43:MAPKs e44:MAPKs{p} e45:Transcription factors e46:Transcription factors{p} e47:Syp adaptors e48:Vav e49:2JAK1{active}:2receptor{p}:2G-CSF:Shc{p}:GRB2{p}:SOS:Vav{p}:Syp{p} e5:G-CSF e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:JAK1:receptor:G-CSF e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p26 p27 p28 p29 p3 p30 p31 p4 p5 p6 p7 p8 p9
Model Detail
67.65792359531245, 3.8322345852223947
866.035294584398, 1165.6807332571768

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
151.29261004024704, 8.355314682113391
757.5205000387426, 987.8229159212648

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
883.4567310017418, 59.016151312407544
32.26554515510271, 49.63930023861954

G-CSF receptor

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
798.6485882094327, 75.01231553674057
34.41658149877621, 25.812436124082158

JAK1

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
877.2518184719142, 138.7483183767734
44.675370214757585, 49.63930023861954

JAK1:G-CSFreceptor

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p1

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
885.1113743430291, 269.35693241005725
37.673932590108976, 52.5682780327102

2JAK1:2receptor:2G-CSF

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p3 p5 p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
521.5142676367458, 227.1504718850943
21.51036343673514, 49.63930023861954

TYK2

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
609.9678342238728, 317.5257749637467
27.53326519902098, 20.649948899265727

JAK2

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
404.9263804769322, 319.1919256320349
21.51036343673514, 49.63930023861954

TYK2{active}

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4

p26 p29

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
508.10444257709094, 371.62402556029565
32.563380956534424, 24.42253571740082

JAK2{active}

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

p27 p30

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
881.8020876604545, 351.39838615699796
35.57483183767734, 49.63930023861954

2JAK1{active}:2receptor:2G-CSF

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p6 p26 p27

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
67.65792359531245, 3.8322345852223947
866.035294584398, 1165.6807332571768

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
885.8020876604545, 431.67698663423675
35.57483183767734, 49.63930023861954

2JAK1{active}:2receptor{p}:2G-CSF

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6 p10 p26 p27

p8 p16 p12 p28

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
615.4628545579401, 523.5327067296846
17.606715167324477, 40.630881155364165

STAT3

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
885.079140142558, 526.0484539372223
30.577697790230555, 50.962829650384236

2JAK1{active}:2receptor {p}:2G-CSF:STAT3

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9 p29 p30

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
886.1379636719698, 620.0168414255608
28.371815437289374, 47.28635906214895

2JAK1{active}:2receptor{p}:2G-CSF:STAT3{p}

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9 p29 p30

p10

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
577.0, 636.0
38.78048780487805, 31.024390243902435

STAT3{p}

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p11 p17

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
604.9847253216759, 697.4997327438178
30.62193093123772, 37.49624195661762

2STAT3{p}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p13

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
786.5, 692.0
34.87190310148651, 48.65846944393467

Shc:GRB2:SOS

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
641.3556551418156, 806.4682267741008
29.264108712579247, 35.83360250519909

STAT1{active}:STAT3{p}

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p17

p14

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
451.30397133611575, 736.9970408584164
24.65697063733018, 30.19220894366961

2STAT3{p}

--

e28

cso30:c:Complex

cso30:i:CC_Nucleolus

--

p13

p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
443.1466361094275, 816.3554528392657
25.5892067874539, 31.33372259688233

STAT1{active}:STAT3{p}

--

e29

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p14

p31

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
84.97862948700036, 19.888443032290933
831.3938828010224, 1133.5683163630415

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
379.43903169419883, 670.7030972785095
49.63930023861954, 26.474293460597085

MRNA

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p15 p31

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
566.0, 429.5
27.679999999999996, 20.759999999999998

STAT1

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
455.0, 439.5
34.239999999999995, 25.68

STAT1{active}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
407.5, 472.0
24.386194405312946, 39.5451801167237

STAT5

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
511.5, 524.0
24.31917890923728, 39.43650633930369

STAT5{active}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
882.0, 778.0
36.0, 60.0

2JAK1{active}:2receptor{p}:2G-CSF:Shc:GRB2:SOS:Vav:Syp

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p24

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
783.0, 1002.0
18.703461178671656, 43.16183348924228

Ras

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
750.0, 1057.0
19.956033676333018, 46.05238540692235

Ras{active}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
604.0, 863.5
32.160000000000004, 24.120000000000005

Raf1

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
652.0, 940.5
40.64, 30.48

Raf1{active}

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
117.02193538662335, 47.98680781466084
767.3072710017761, 1077.3715867983008

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
613.0, 1018.5
45.17206681424834, 27.856107868786477

MEK

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
534.0, 1031.0
43.41463414634147, 34.731707317073166

MEK{p}

--

e41

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p20

p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
223.0, 999.0
41.46341463414634, 33.17073170731707

MAPKs{p}

--

e42

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p21

p22

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
330.0, 1030.5
35.52, 26.64

MAPKs

--

e43

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
310.0, 907.0
43.65853658536586, 34.926829268292686

MAPKs{p}

--

e44

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p22

p23

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
186.0, 813.5
48.9152747031596, 30.164419400281744

Transcription factors

--

e45

cso30:c:Protein

cso30:i:CC_NuclearChromosome

--

--

p23

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
239.0, 712.5
50.35218353793519, 31.050513181726707

Transcription factors{p}

--

e46

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
831.5, 799.0
25.31696518414168, 41.05453813644596

Syp adaptors

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
731.0, 787.0
18.60617399438728, 42.93732460243218

Vav

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
882.0, 890.0
36.0, 60.0

2JAK1{active}:2receptor{p}:2G-CSF:Shc{p}:GRB2{p}:SOS:Vav{p}:Syp{p}

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p18

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1035.6555199753707, 151.1811580904298
25.491630449903017, 41.33777910795083

G-CSF

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
127.86246176518881, 616.6493059173027
416.72030185518094, 350.32952869865954

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
172.8713584273869, 624.9516064484355
243.66885434362487, 339.5390914697476

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
133.29456998304028, 621.3251620498311
405.8560854194781, 340.97781643360275

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
134.0705854427334, 622.0445245317585
404.3040545000914, 339.5390914697476

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
127.86246176518881, 616.6493059173027
416.72030185518094, 350.32952869865954

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
127.86246176518881, 616.6493059173027
416.72030185518094, 350.32952869865954

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
130.0705854427334, 622.0445245317585
404.3040545000914, 339.5390914697476

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
432.0605219648735, 760.5218023027896
26.034394788515463, 21.84739911162278

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
363.7711615118836, 861.2325497726297
73.72146867084196, 61.865173445759204

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
127.86246176518881, 616.6493059173027
416.72030185518094, 350.32952869865954

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
881.8020876604545, 207.24333871084065
36.11933541631562, 50.39907267392877

JAK1:receptor:G-CSF

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p1

p7

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
226.081092188708, 772.3328536742608
13.196919653588989, 5.890193621116164

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
225.64040968651653, 754.7669024473695
45.16995647458735, 75.37018607817035

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
244.58975728073432, 803.7881616852056
7.050920035057521, 6.536167898377908

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
84.72425619492071, 48.27780199259864
766.4884357365352, 1006.8040425931054

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
69.41055625142685, 86.40408440897747
720.9103381467753, 970.343006617173

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
90.9995775062605, 76.02460615209284
826.67651002776, 1103.1475757852677

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
987.293272218855, 215.32315021445072
24.81965011930977, 24.81965011930977

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e13

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c6 : 1
stoichiometry:c3 : 1

m5*m13*0.1

nodelay

--

true

0

false

PMID: 12005202, 7503988 Upon binding of G-CSF to its receptor, various cellular proteins including the receptor itself are tyrosine phosphorylated

Go back
723.7567981378468, 655.9740262044149
24.81965011930977, 24.81965011930977

p10

p10

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e23

e24 e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c89 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 12005202 The phosphorylated STAT 3 releases from the receptor by forming a homodimer or heterodimer with STAT 1 and translocates to the nucleus [96].

Go back
672.0039042000111, 679.7576063475868
24.81965011930977, 24.81965011930977

p11

p11

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 12005202 STAT 3 releases from the receptor by forming a homodimer or heterodimer with STAT 1 and translocates to the nucleus [96].

Go back
937.0, 613.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e26 e48 e47

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c49 : 1

m20*m26*m48*m47*0.1

nodelay

--

true

0

false

PMID: 12005202, 7579336, 8608222, 7509213, 9824671 The activation of ras seems to be mediated by various molecules such as the Shc, Grb2 and Syp adaptors, and the Vav guanine nucleotide exchanger, as these molecules are phosphorylated by G-CSF in various cells responding to GCSF [107, 110, 111] and bind directly to the G-CSF receptor [112]. It is likely that JAK family kinases, activated through the membraneproximal region of the receptor, tyrosine-phosphorylate Tyr764 on the receptor, to which adaptor molecules are recruited which activate the ras/MAP kinase pathway

Go back
547.1481841045627, 727.7368794741164
24.81965011930977, 24.81965011930977

p13

p13

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e25

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c38 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 12005202 STAT 3 releases from the receptor by forming a homodimer or heterodimer with STAT 1 and translocates to the nucleus [96].

Go back
563.1274572310928, 803.6133264430342
24.81965011930977, 24.81965011930977

p14

p14

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 12005202 The phosphorylated STAT3 released from the receptor by forming a homdimer or a hetrodimer with STAT1 translocates to the nucleus.

Go back
308.3952901667269, 699.7161526006457
31.81965011930977, 31.81965011930977

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 12005202, 9209832 The phosphorylated STAT dimerize and translocate into the nucleus, where they induce the expression of specific genes [96, 108].

Go back
691.0, 443.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m20*m31*0.1

nodelay

--

true

0

false

PMID: 12005202, 8977235, 7521688 Among the STAT family members, G-CSF activates STAT1, STAT3 and STAT5.

Go back
481.0, 617.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e24

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m32*m24*0.1

nodelay

--

true

0

false

PMID: 12005202 STAT 3 releases from the receptor by forming a homodimer or heterodimer with STAT 1 and translocates to the nucleus [96].

Go back
955.0, 1031.0
25.0, 25.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e49

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c69 : 1
stoichiometry:c53 : 1

m36*m49*0.1

nodelay

--

true

0

false

PMID: 12005202 It is likely that JAK family kinases, activated through the membraneproximal region of the receptor, tyrosine-phosphorylate Tyr764 on the receptor, to which adaptor molecules are recruited which activate the ras/MAP kinase pathway

Go back
681.0, 845.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c52 : 1
stoichiometry:c55 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 12005202 The activation of G-protein ras leads to the activation of the serine/threonine Kinase Raf-1.

Go back
672.0453579469512, 131.3024233409804
24.81965011930977, 24.81965011930977

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c4 : 1
stoichiometry:c2 : 1

m11*m12*0.1

nodelay

--

true

0

false

PMID: 12005202, 7512720 JAK1 is associated constitutively with the G-CSF receptor and becomes activated by the binding of G-CSF to the receptor [96, 103].

Go back
485.0, 929.0
30.0, 30.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e40 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c56 : 1
stoichiometry:c58 : 1

m40*m39*0.1

nodelay

--

true

0

false

PMID: 12005202 The activation of the Gprotein ras leads to the activation of the serine/threonine kinase Raf-1 followed by sequential phosphorylation of the tyrosine/threonine MAP kinase activator MEK (mitogenactivated/ extracellular signal kinase) and the serine/threonine MAP kinases.

Go back
389.0, 973.0
30.0, 30.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e43

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m41*m43*0.1

nodelay

--

true

0

false

PMID: 12005202 The activation of the Gprotein ras leads to the activation of the serine/threonine kinase Raf-1 followed by sequential phosphorylation of the tyrosine/threonine MAP kinase activator MEK (mitogenactivated/ extracellular signal kinase) and the serine/threonine MAP kinases.

Go back
165.0, 909.0
30.0, 30.0

p22

p22

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 12005202, 8704229 Activated MAP kinases carry the signal to the nucleus where they phosphorylate transcription factors

Go back
297.0, 837.0
30.0, 30.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e45 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c64 : 1
stoichiometry:c66 : 1

m45*m44*0.1

nodelay

--

true

0

false

PMID: 12005202, 8704229 Activated MAP kinases carry the signal to the nucleus where they phosphorylate transcription factors

Go back
957.0, 849.0
30.0, 30.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e35

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 12005202, 7579336, 8608222, 7509213, 9824671 The activation of ras seems to be mediated by various molecules such as the Shc, Grb2 and Syp adaptors, and the Vav guanine nucleotide exchanger, as these molecules are phosphorylated by G-CSF in various cells responding to GCSF [107, 110, 111] and bind directly to the G-CSF receptor [112].

Go back
541.0, 333.0
30.0, 30.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c79 : 1
stoichiometry:c20 : 1

m17*m19*0.1

nodelay

--

true

0

false

PMID: 12005202, 8547634 The activated JAK kinases tyrosine-phosphorylate Tyr703 of the G-CSF receptor, to which STAT 3 is recruited through its Src-homolog-2 (SH2) region [101].

Go back
609.0, 397.0
30.0, 30.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c80 : 1
stoichiometry:c78 : 1

m18*m19*0.1

nodelay

--

true

0

false

PMID: 12005202, 8547634 The activated JAK kinases tyrosine-phosphorylate Tyr703 of the G-CSF receptor, to which STAT 3 is recruited through its Src-homolog-2 (SH2) region [101].

Go back
603.0, 479.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c81 : 1

m20*m33*0.1

nodelay

--

true

0

false

PMID: 12005202, 8977235, 7521688 Among the STAT family members, G-CSF activates STAt1, STAT3 and STAT5.

Go back
601.0, 569.0
30.0, 30.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m17*m22*0.1

nodelay

--

true

0

false

PMID: 12005202 JAK kinases then phosphorylate STAT 3 bound to the receptor.

Go back
628.0453579469512, 200.03459040534636
24.81965011930977, 24.81965011930977

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 12005202, 7512720 JAK1 is associated constitutively with the G-CSF receptor and becomes activated by the binding of G-CSF to the receptor [96, 103].

Go back
689.0, 481.0
30.0, 30.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22 e18

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m22*m18*0.1

nodelay

--

true

0

false

PMID: 12005202 JAK kinases then phosphorylate STAT 3 bound to the receptor.

Go back
369.0, 753.0
29.0, 29.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c86 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 12005202, 9209832 The phosphorylated STAT dimerize and translocate into the nucleus, where they induce the expression of specific genes [96, 108].

Go back
615.3339177560556, 279.36460396139125
24.81965011930977, 24.81965011930977

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15 e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c27 : 1
stoichiometry:c13 : 1

m15*m14*0.1

nodelay

--

true

0

false

PMID: 12005202, 7522448, 8977235, 9015216 Also the kinases JAK2 and TYK2 are activated

Go back
696.0453579469512, 315.6946175174361
24.81965011930977, 24.81965011930977

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 e14

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1

m16*m14*0.1

nodelay

--

true

0

false

PMID: 12005202, 7522448, 8977235, 9015216 Also the kinases JAK2 and TYK2 are activated

Go back
819.2825046772497, 396.0453579469514
24.81965011930977, 24.81965011930977

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 12005202, 8547634 The activated JAK kinases tyrosine-phosphorylate Tyr703 of the G-CSF receptor, to which STAT 3 is recruited through its Src-homolog-2 (SH2) region [101].

Go back
1007.293272218855, 279.1274572310927
24.81965011930977, 24.81965011930977

p7

p7

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e6

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 12005202 G-CSF induces the dimerization of the receptor, which then activates JAK kinases through its membrane-proximal Box 1 and Box 2 region.

Go back
715.4475114552723, 543.6539719802352
24.81965011930977, 24.81965011930977

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 12005202, 8547634 The activated JAK kinases tyrosine-phosphorylate Tyr703 of the G-CSF receptor, to which STAT 3 is recruited through its Src-homolog-2 (SH2) region [101].

Go back
635.973217994675, 620.0047124097504
24.81965011930977, 24.81965011930977

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c26 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 12005202 JAK kinases then phosphorylate STAT 3 bound to the receptor.

Go back
1016.2235169765557, 186.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 220.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 257.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.0, 328.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.77308548071, 295.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.6557797037668, 332.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.9547222571043, 466.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.8937377092619, 299.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.2299027111483, 384.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 416.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 344.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.0, 145.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 353.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 545.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 552.2206057307866

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.6260842995384, 557.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.6851645952441, 502.2222162685043

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 357.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 633.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.998933990701, 292.1305948406645

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.9160918645142, 646.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.9426661822708, 654.9560616700882

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.9924492668405, 228.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 661.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.5244311975335, 697.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 456.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 481.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 641.0897866086184

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.4432671425367, 722.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.9646360217126, 817.7513807567653

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.9355982368308, 818.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.9364913754995, 742.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
403.97927454946927, 785.3149107106393

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.3456897029698, 95.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.7401971471413, 722.0222136690729

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 696.8718326344709

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 442.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.9984319874408, 452.1583847918305

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.9391662294607, 458.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 492.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 465.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.8491861843701, 636.5460518241941

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 647.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.2203172225662, 643.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.7152317131197, 89.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 1025.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.2367586106818, 882.6809446630958

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.8829417066803, 1046.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 864.7354436625493

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.8848002049721, 875.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.9787730468599, 945.5823921932015

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.7075489304051, 958.3599068047633

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 959.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.44994223764604, 996.915194788644

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.0, 178.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 1008.7587543633655

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.8894389285768, 991.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.58769875490663, 945.5538553641524

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 924.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
318.12125186416836, 874.7136431424303

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
235.0, 834.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.8879528204617, 751.4605447861927

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.0, 822.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.3409919128368, 876.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 950.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 241.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 389.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.0, 414.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.9721889971632, 349.6664852537821

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
930.9949028347804, 292.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.9315232233716, 378.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.9586920159416, 499.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.0, 394.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0, 507.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.9518304787795, 554.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 587.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 704.7927776019468

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 485.27452247052383

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.6216784986375, 218.4310526245654

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 646.1821333661019

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 649.9678277419434

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back