1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14552837.csml convertedTime:2009.07.01.10:42

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The interferon in TLR signaling: more than just antiviral.
Authors Hertzog PJ, O'Neill LA, Hamilton JA.
Affiliation Centre for Functional Genomics and Human Disease, Monash Institute ofReproduction and Development, Monash University, Clayton, Victoria 3168,Australia. paul.hertzog@med.monash.edu.au
Abstract The Toll-like receptor (TLR) system is responsible for the recognition ofinfectious agents leading to initiation of the primary innate, and lateradaptive, immune response. Genetic technologies have enabled the discovery ofnew factors involved in these systems, their genetic manipulation and the globalanalyses of their effects on gene expression. Furthermore, this increasedunderstanding has resulted in the need to reassess our preconceptions about thefunctions of well-known molecules. For example, type I interferons (IFNs), whichwere discovered as antiviral proteins, are now known to be produced in responseto TLR activation by many pathogens, including bacteria. Should we be surprised?Has the inflammatory response unexpectedly highjacked the body's antiviralsystem? Or are we too easily blinkered by preconceptions from how a compound wasdiscovered?
PMID 14552837
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010453:IFN-gamma G010522:RANTES G010559:cycD2 G010657:IL-12 p40 G010713:IRF-7 MO000000058:NF-kappaB MO000000077:MAPKs MO000000084:M-CSFR MO000000100:M-CSF MO000000212:TRAF6 MO000000213:IRAK MO000000215:IkappaB MO000000289:TNF-alpha MO000007384:IL-6 MO000007545:IFNAR1 MO000007548:IFNAR2 MO000007694:IRF-3 MO000007702:IRF-7 MO000013119:STAT1 MO000016573:MyD88 MO000016660:IFNbeta MO000016665:IFNgamma MO000016882:LPS MO000017115:SOCS/CIS family MO000017265:IL-12 MO000017736:cyclin D2 MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019881:RANTES MO000021201:iNOS MO000022224:dsRNA MO000033676:IL-12R MO000041125:TRIF MO000042012:TLR9 MO000068831:MAL MO000069094:ISG15 e1: e10: e11:NO e12:LPS: TLR4: MyD88: MAL e13:LPS: TLR4: MyD88: MAL: IRAK e14:IRAK {activated} : TRAF6 e15:MCP-5 e16:LPS: TLR4: MyD88: MAL: IRAK {activated} e17:IRAK {activated} e18:IRAK {activated} : TRAF6 {activated} e19:MAPKs {activated} e2: e20:NF-kappaB {activated} e21:IkappaB {activated} e22:dsRNA: TLR3 e23:dsRNA: TLR3: TRIF e24:IRF-3 {activated} e25:IFN-alpha4 e26:IFNalpha-4 e27:IFNbeta: IFNAR1 e28:IFNbeta: IFNAR2 e29:STAT1 {activated} e3: e30:IFN-alpha e31:IRF-7 {activated} e32:Isg15 e33:M-CSF: M-CSFR e34:MCP-5 e35:IL-12: IL-12R e36:TLR ligand e37:TLR ligand : TLR e38:IRAK: SOCS e39:SOCS e4: e40:TLR9 ligand: TLR9 e41:TLR9 ligand e5:LPS: TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Nos2 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p5 p6 p7 p8 p9
Model Detail
429.0, 857.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
651.0, 887.0
26.0, 26.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p17

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
719.0, 867.0
25.0, 25.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
714.0, 1042.0
28.0, 28.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p38

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
496.0, 796.0
31.0, 31.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
743.0, 919.0
33.5, 33.5

cycD2

--

G010559

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m93519

10

false

infinite

0

unit false false false
TRANSFACG010559

--

Go back
661.0, 1081.0
30.5, 30.5

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
470.0, 1066.0
28.0, 28.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
945.0, 597.0
30.5, 30.5

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
882.0, 474.0
36.0, 36.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
194.0, 1138.0
28.0, 28.0

M-CSFR

--

MO000000084

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000084

--

Go back
44.0, 1076.0
32.0, 32.0

M-CSF

--

MO000000100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008001
TRANSPATHMO000000100

--

Go back
759.0, 348.0
33.0, 33.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
761.0, 298.0
29.0, 29.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p41

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
733.0, 525.0
30.0, 30.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
877.0, 749.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
917.0, 725.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
195.0, 923.0
26.0, 26.0

IFNAR1

--

MO000007545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p23

true true true true

csml-variable:Double

m898

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000007545

--

Go back
194.0, 1006.0
28.0, 28.0

IFNAR2

--

MO000007548

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m901

10

false

infinite

0

unit false false false
InterProIPR000282
TRANSPATHMO000007548

--

Go back
372.0, 254.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p30 p31

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
662.0, 606.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
325.0, 941.0
30.0, 30.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
756.0, 209.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
62.0, 838.0
28.0, 28.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
833.0, 1117.0
29.0, 29.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
805.0, 29.0
29.0, 29.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
605.0, 393.0
30.0, 30.0

SOCS/CIS family

--

MO000017115

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2002

10

false

infinite

0

unit false false false
TRANSPATHMO000017115

--

Go back
1063.0, 1103.0
34.0, 34.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
856.0, 984.0
32.0, 32.0

cyclin D2

--

MO000017736

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m2493

10

false

infinite

0

unit false false false
InterProIPR006670
TRANSPATHMO000017736

--

Go back
750.0, 146.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
590.0, 142.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
238.0, 147.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
504.0, 628.0
31.0, 31.0

RANTES

--

MO000019881

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m4410

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019881

--

Go back
876.0, 788.0
31.0, 31.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p7

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
244.0, 73.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
988.0, 1088.0
32.0, 32.0

IL-12R

--

MO000033676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m12340

10

false

infinite

0

unit false false false
TRANSPATHMO000033676

--

Go back
430.0, 207.0
27.0, 27.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
985.0, 757.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
757.0, 254.0
29.0, 29.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p31

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
559.0, 571.0
33.0, 33.0

ISG15

--

MO000069094

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m43938

10

false

infinite

0

unit false false false
TRANSPATHMO000069094

--

Go back
182.75, 124.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
191.0, 144.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
876.5, 896.5
39.26470588235294, 23.558823529411768

NO

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
991.875, 146.5
32.25, 45.0

LPS: TLR4: MyD88: MAL

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
999.875, 226.5
32.25, 45.0

LPS: TLR4: MyD88: MAL: IRAK

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
763.875, 402.5
32.25, 45.0

IRAK {activated} : TRAF6

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
460.0, 820.0
31.0, 31.0

MCP-5

--

e15

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSFACG027316

--

Go back
999.875, 286.5
32.25, 45.0

LPS: TLR4: MyD88: MAL: IRAK {activated}

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
873.0, 350.0
29.0, 29.0

IRAK {activated}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
763.875, 458.5
32.25, 45.0

IRAK {activated} : TRAF6 {activated}

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
878.0, 534.0
36.0, 36.0

MAPKs {activated}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
182.75, 124.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
840.0, 600.0
32.0, 32.0

NF-kappaB {activated}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
685.0, 541.0
30.0, 30.0

IkappaB {activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
298.625, 136.5
27.498708548575234, 33.67188801866355

dsRNA: TLR3

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
370.625, 123.5
34.659681719713376, 42.4404265955674

dsRNA: TLR3: TRIF

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
372.0, 309.0
32.0, 32.0

IRF-3 {activated}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
477.5, 920.0
45.0, 24.0

IFN-alpha4

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p22

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
118.5, 809.125
35.1348359830952, 21.66648218957537

IFNalpha-4

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
194.625, 879.5
27.539535077487088, 33.72187968671888

IFNbeta: IFNAR1

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
194.625, 955.5
27.498708548575237, 33.67188801866355

IFNbeta: IFNAR2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
329.0, 1009.0
30.0, 30.0

STAT1 {activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
199.87518862352903, 142.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
584.0, 1064.0
32.0, 32.0

IFN-alpha

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
710.0, 650.0
28.0, 28.0

IRF-7 {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
561.0, 797.0
29.5, 29.5

Isg15

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p36

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
Affymetrix4950
MGDG1p2
ProteomeHumanPSD/Isg15
RefSeqNM_015783
TRANSFACG043147
UnigeneMm.451527

--

Go back
190.625, 1075.5
27.441551408098654, 33.6018996833861

M-CSF: M-CSFR

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
445.0, 657.0
30.0, 30.0

MCP-5

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
984.625, 1037.5
31.00979003499417, 37.97117147142143

IL-12: IL-12R

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
589.5, 67.375
37.72407732864674, 24.520650263620386

TLR ligand

--

e36

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
665.625, 129.5
32.830653224462594, 40.20079986668888

TLR ligand : TLR

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
665.625, 298.5
28.739835027495417, 35.191634727545406

IRAK: SOCS

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
601.0, 769.0
30.0, 30.0

SOCS

--

e39

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p42 p43

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
231.55678757705792, 172.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
984.625, 689.5
29.858481919680052, 36.561406432261286

TLR9 ligand: TLR9

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1050.5, 760.375
34.77152899824253, 22.601493848857643

TLR9 ligand

--

e41

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p44

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
836.5, 134.0
30.14630894850858, 36.91384769205132

LPS: TLR4

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
363.0, 726.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
413.29367619468036, 736.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
369.06992643728904, 731.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
369.93705878547314, 732.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
363.0, 726.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
363.0, 726.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
369.93705878547314, 732.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
702.9158804881849, 899.4264696368291
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
626.6082338479803, 1020.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
363.0, 726.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
768.0, 880.0
23.0, 23.0

Nos2

--

e6

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
Affymetrix104420_at
EnsemblENSMUSG00000020826
MGDNos2
ProteomeHumanPSD/Nos2
RefSeqNM_010927
TRANSFACG001073
UnigeneMm.2893

--

Go back
472.7511016961721, 913.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
472.25867587120234, 892.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
493.43298634490145, 951.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
194.0, 130.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
197.0, 151.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
205.0, 172.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
45.0, 1013.0
30.0, 30.0

p1

p1

cso30:i:CE_CellProliferation

cso30:i:CC_CellComponent

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 14552837 Consistent with this, the proliferative response of bone-marrow-derived macrophages (BMMs) to colony-stimulating factor 1 [CSF1 or macrophage colony-stimulating factor (M-CSF)] was increased in IFNAR1¡Ý/¡Ý cells, as expected from the removal of an inhibitor of proliferation.

Go back
826.0, 351.0
27.0, 27.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c22 : 1
stoichiometry:c17 : 1

m183*m17*0.1

nodelay

--

true

0

false

PMID: 14552837 This is followed by the recruitment and activation of IRAK and TRAF6.

Go back
925.0, 294.0
30.0, 30.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 14552837 This is followed by the recruitment and activation of IRAK and TRAF6.

Go back
927.0, 352.0
25.0, 25.0

p12

p12

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 14552837 This is followed by the recruitment and activation of IRAK and TRAF6.

Go back
825.0, 410.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 14552837 This is followed by the recruitment and activation of IRAK and TRAF6.

Go back
811.0, 539.0
25.0, 25.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m69*m18*0.1

nodelay

--

true

0

false

PMID: 14552837 This results in the activation of both the MAP kinases and NF-kappaB.

Go back
298.0, 75.0
27.0, 27.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 14552837, 12471095, 12539043 Although previous studies would lead us to interpret data from overexpression or dominant-negative experiments with caution, the data on TLR3 activation of IFN-beta by TRIF/TICAM, but not by MyD88 or Mal/TIRAP, is consistent between these studies.

Go back
767.0, 603.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m186*m18*0.1

nodelay

--

true

0

false

PMID: 14552837 This results in the activation of both the MAP kinases and NF-kappaB. PMID: 14552837 Recent studies demonstrated that IKbeta kinases, previously known to be involved in NF-kappaB activation, are essential for activation of IRF3 and 7.

Go back
745.0, 725.0
30.0, 30.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c32 : 1
stoichiometry:c34 : 1

m93248*m21*0.1

nodelay

--

true

0

false

PMID: 14552837, 11257452 LPS effects are mediated by the products of TLR response genes (TRGs), such as inducible nitric oxide synthase (NOS2), which generates microbicidal nitric oxide (NO) and cytokines such as interleukin-6 (IL-6), tumor necrosis factor-greek small letter alpha (TNF-alpha), interferons (IFNs) and chemokines.

Go back
785.0, 749.0
30.0, 30.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c33 : 1
stoichiometry:c31 : 1

m93309*m21*0.1

nodelay

--

true

0

false

PMID: 14552837, 11257452 LPS effects are mediated by the products of TLR response genes (TRGs), such as inducible nitric oxide synthase (NOS2), which generates microbicidal nitric oxide (NO) and cytokines such as interleukin-6 (IL-6), tumor necrosis factor-greek small letter alpha (TNF-alpha), interferons (IFNs) and chemokines.

Go back
299.0, 208.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m18998*m19*0.1

nodelay

--

true

0

false

PMID: 14552837, 12471095, 12539043 Although previous studies would lead us to interpret data from overexpression or dominant-negative experiments with caution, the data on TLR3 activation of IFN-beta by TRIF/TICAM, but not by MyD88 or Mal/TIRAP, is consistent between these studies.

Go back
17.0, 741.0
30.0, 30.0

p2

p2

cso30:i:CE_CellDifferentiation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 14552837, 8783497 Furthermore, IFN-beta itself can regulate the differentiation or activation of almost all effector cells of the immune system, including B cells and DCs.

Go back
291.0, 312.0
25.0, 25.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m977*m23*0.1

nodelay

--

true

0

false

PMID: 14552837, 12471095, 12539043 Although previous studies would lead us to interpret data from overexpression or dominant-negative experiments with caution, the data on TLR3 activation of IFN-beta by TRIF/TICAM, but not by MyD88 or Mal/TIRAP, is consistent between these studies. PMID: 14552837 However, in response to double-stranded RNA (poly I:C) activation of a related TLR3 receptor, the TRIF?TIR-containing adaptor molecule (TICAM) leads to IRF3 activation.

Go back
318.0, 838.0
27.0, 27.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m93217*m24*0.1

nodelay

--

true

0

false

PMID: 14552837, 12471095, 12539043 Although previous studies would lead us to interpret data from overexpression or dominant-negative experiments with caution, the data on TLR3 activation of IFN-beta by TRIF/TICAM, but not by MyD88 or Mal/TIRAP, is consistent between these studies. PMID: 14552837 First, activation of IRF3 generated IFN-beta and -alpha4. PMID: 14552837, 11698465 Recent analyses of TLR signaling have identified the LPS induction of additional IFN response genes (IRGs), including IFN-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 5 (MCP-5), RANTES and IFN-stimulated gene 15 (ISG15), as well as IFN-beta through a so-called MyD88-independent pathway.

Go back
402.0, 918.0
27.0, 27.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c51 : 1

m25*m24*0.1

nodelay

--

true

0

false

PMID: 14552837 First, activation of IRF3 generated IFN-beta and -alpha4.

Go back
104.0, 884.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m1636*m898*0.1

nodelay

--

true

0

false

PMID: 14552837 These acted through their cognate receptors, IFNAR1 and IFNAR2, to activate STAT1 to induce IRF7.

Go back
64.0, 960.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m1636*m901*0.1

nodelay

--

true

0

false

PMID: 14552837 These acted through their cognate receptors, IFNAR1 and IFNAR2, to activate STAT1 to induce IRF7.

Go back
280.0, 908.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m27*m1357*0.1

nodelay

--

true

0

false

PMID: 14552837 These acted through their cognate receptors, IFNAR1 and IFNAR2, to activate STAT1 to induce IRF7.

Go back
276.0, 976.0
23.0, 23.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m28*m1357*0.1

nodelay

--

true

0

false

PMID: 14552837 These acted through their cognate receptors, IFNAR1 and IFNAR2, to activate STAT1 to induce IRF7.

Go back
436.0, 1012.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 14552837 These acted through their cognate receptors, IFNAR1 and IFNAR2, to activate STAT1 to induce IRF7.

Go back
532.0, 1068.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c69 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 14552837 Activation of IRF7 then induced the remaining IFN-alpha subtype.

Go back
711.0, 607.0
25.0, 25.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m22*m980*0.1

nodelay

--

true

0

false

PMID: 14552837 Recent studies demonstrated that IKbeta kinases, previously known to be involved in NF-kappaB activation, are essential for activation of IRF3 and 7.

Go back
705.0, 713.0
22.0, 22.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m93631*0.1

nodelay

--

true

0

false

PMID: 14552837 Activation of IRF7 then induced the remaining IFN-alpha subtype.

Go back
450.0, 310.0
27.0, 27.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m977*m22*0.1

nodelay

--

true

0

false

PMID: 14552837 Recent studies demonstrated that IKbeta kinases, previously known to be involved in NF-kappaB activation, are essential for activation of IRF3 and 7.

Go back
451.0, 259.0
25.0, 25.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c79 : 1

m977*m5*m43675*0.1

nodelay

--

true

0

false

PMID: 14552837, 12062447 Similar studies indicated that Mal was necessary for the activation of IRF3 by LPS but not by poly I:C.

Go back
499.0, 683.0
25.0, 25.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c94 : 1
stoichiometry:c97 : 1

m93487*m24*0.1

nodelay

--

true

0

false

PMID: 14552837, 11698465 Recent analyses of TLR signaling have identified the LPS induction of additional IFN response genes (IRGs), including IFN-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 5 (MCP-5), RANTES and IFN-stimulated gene 15 (ISG15), as well as IFN-beta through a so-called MyD88-independent pathway.

Go back
858.0, 926.0
27.0, 27.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c89 : 1

m93519*m5*0.1

nodelay

--

true

0

false

PMID: 14552837, 11052814 We then demonstrated that LPS induction of NOS2 [22] and cyclin D2 [23] was also absent in IFNAR1¡Ý/¡Ý cells.

Go back
122.0, 1078.0
27.0, 27.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m89*m76*0.1

nodelay

--

true

0

false

PMID: 14552837 Consistent with this, the proliferative response of bone-marrow-derived macrophages (BMMs) to colony-stimulating factor 1 [CSF1 or macrophage colony-stimulating factor (M-CSF)] was increased in IFNAR1¡Ý/¡Ý cells, as expected from the removal of an inhibitor of proliferation.

Go back
435.0, 719.0
25.0, 25.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c93 : 1
stoichiometry:c98 : 1

m15*m24*0.1

nodelay

--

true

0

false

PMID: 14552837, 11698465 Recent analyses of TLR signaling have identified the LPS induction of additional IFN response genes (IRGs), including IFN-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 5 (MCP-5), RANTES and IFN-stimulated gene 15 (ISG15), as well as IFN-beta through a so-called MyD88-independent pathway.

Go back
564.0, 676.0
23.0, 23.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m32*m24*0.1

nodelay

--

true

0

false

PMID: 14552837, 11698465 Recent analyses of TLR signaling have identified the LPS induction of additional IFN response genes (IRGs), including IFN-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 5 (MCP-5), RANTES and IFN-stimulated gene 15 (ISG15), as well as IFN-beta through a so-called MyD88-independent pathway.

Go back
1065.0, 1041.0
30.0, 30.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m2121*m12340*0.1

nodelay

--

true

0

false

PMID: 14552837 IFN-gamma is produced predominantly by T cells, natural killer (NK) cells and NKT cells in response to mitogens or cytokines (e.g. IL-12).

Go back
833.0, 1041.0
29.0, 29.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c102 : 1

m93423*m35*0.1

nodelay

--

true

0

false

PMID: 14552837 IFN-gamma is produced predominantly by T cells, natural killer (NK) cells and NKT cells in response to mitogens or cytokines (e.g. IL-12).

Go back
833.0, 1165.0
30.0, 30.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c105 : 1

m37*m93589*0.1

nodelay

--

true

0

false

PMID: 14552837, 11477402 Not only is the TLR response the cornerstone of innate immunity but the products of TLR signaling (e.g. IFNs, IL-12) also shape the adaptive immune response.

Go back
61.0, 741.0
30.0, 30.0

p4

p4

cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14552837, 8783497, 8658169, 10871875 It can polarize the immune response towards a T helper 1 (Th1) response [27], promote survival of memory T cells [28] and prevent T-cell apoptosis (which could be responsible for persistent T-cell infiltrates in chronic inflammation, such as rheumatoid arthritis).

Go back
669.0, 69.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m36*m3962*0.1

nodelay

--

true

0

false

PMID: 14552837, 11477402 Not only is the TLR response the cornerstone of innate immunity but the products of TLR signaling (e.g. IFNs, IL-12) also shape the adaptive immune response.

Go back
667.0, 355.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c114 : 1
stoichiometry:c112 : 1

m184*m2002*0.1

nodelay

--

true

0

false

PMID: 14552837 Although the rapidity of the effect of SOCS in vitro and the association with IRAK suggested that there was a direct effect of SOCS on TLR signaling.

Go back
605.0, 665.0
27.0, 27.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c113 : 1

m39*m5*0.1

nodelay

--

true

0

false

PMID: 14552837, 12433365, 12433373, 10453004 SOCS are induced after activation of TLR4 [51 and 52] and TLR9[50].

Go back
663.0, 691.0
25.0, 25.0

p43

p43

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c122 : 1
stoichiometry:c117 : 1

m39*m40*0.1

nodelay

--

true

0

false

PMID: 14552837, 12433365, 12433373, 10453004 SOCS are induced after activation of TLR4 [51 and 52] and TLR9[50].

Go back
1057.0, 697.0
22.0, 22.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m41*m19828*0.1

nodelay

--

true

0

false

Go back
895.0, 599.0
25.0, 25.0

p16

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m42*m22*0.1

nodelay

--

true

0

false

PMID: 14552837 This results in the activation of both the MAP kinases and NF-kappaB. PMID: 14552837 Recent studies demonstrated that IKbeta kinases, previously known to be involved in NF-kappaB activation, are essential for activation of IRF3 and 7.

Go back
750.0, 62.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 14552837, 9851930, 10201887 The prototype PAMP is lipopolysaccharide (LPS), a surface component of Gram-negative bacteria, which activates TLR4.

Go back
817.0, 789.0
29.0, 29.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c35 : 1
stoichiometry:c5 : 1

m6*m21*0.1

nodelay

--

true

0

false

PMID: 14552837, 11257452 LPS effects are mediated by the products of TLR response genes (TRGs), such as inducible nitric oxide synthase (NOS2), which generates microbicidal nitric oxide (NO) and cytokines such as interleukin-6 (IL-6), tumor necrosis factor-greek small letter alpha (TNF-alpha), interferons (IFNs) and chemokines.

Go back
882.0, 850.0
27.0, 27.0

p7

p7

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m5576*0.1

nodelay

--

true

0

false

PMID: 14552837, 11257452 LPS effects are mediated by the products of TLR response genes (TRGs), such as inducible nitric oxide synthase (NOS2), which generates microbicidal nitric oxide (NO) and cytokines such as interleukin-6 (IL-6), tumor necrosis factor-greek small letter alpha (TNF-alpha), interferons (IFNs) and chemokines.

Go back
835.0, 212.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c18 : 1
stoichiometry:c9 : 1

m5*m1572*m43675*0.1

nodelay

--

true

0

false

PMID: 14552837, 11477402, 12072368 LPS activation of TLR4 signaling triggers the recruitment of the adaptor molecule MyD88 through their Toll?IL-1 receptor (TIR) domains. PMID: 14552837, 11544529, 11526399 The MyD88 adaptor-like (Mal) protein [38], also known as TIR-containing adaptor protein (TIRAP) [39], was discovered as a TIR-domain-containing adaptor that, unlike MyD88, does not have a death domain.

Go back
927.0, 236.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c13 : 1
stoichiometry:c12 : 1

m184*m12*0.1

nodelay

--

true

0

false

PMID: 14552837 This is followed by the recruitment and activation of IRAK and TRAF6.

Go back
783.9459451369956, 52.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 225.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 1070.2264150943397

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 1056.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 1070.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 1056.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
870.0, 1056.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
863.0, 1126.0130708141196

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 81.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 99.54260875358183

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 94.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 11.775679004156245

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 256.9336211875167

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 1104.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.9645027097611, 322.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 342.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 430.99993169952916

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 381.38925153189456

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 699.9939350536706

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.9999848372843, 107.91674780156404

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.4955493259542, 430.85896508540645

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 722.3855132026658

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1068.0, 727.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 249.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 723.5172413793103

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 708.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.9992745491421, 704.1077343373622

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.9223021817833, 641.4471571729315

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 741.6996765185003

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.1808595010745, 678.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.9699247055655, 613.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.0, 560.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.1958868009881, 188.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.3148177390107, 262.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 309.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.464060241731, 321.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.6568542494924, 378.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 236.96911150685466

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 365.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 97.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 199.56549279443894

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.0, 365.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 365.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 425.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.8551517954508, 439.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 89.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.3000400080607, 506.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 552.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 555.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 87.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 504.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.0, 764.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.8973855439314, 632.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
808.816, 632.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.0, 740.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0109386163874, 632.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 761.8645277308548

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.0, 785.9216145650802

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.4, 571.8

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 504.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0, 824.8697006676138

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 108.17940388792766

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 102.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 221.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 170.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 167.65685424949237

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.6746825652904, 280.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 325.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.37764431375695, 166.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.87542060406787, 855.4063251078693

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
98.0, 852.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
846.0, 804.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.84830884063723, 341.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
161.42987788174437, 829.9659593156963

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 932.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 341.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
89.0, 866.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.3587460644701, 904.1382887627888

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.0, 896.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
76.0, 866.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
94.51629430177135, 978.739583904384

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
87.0, 972.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 819.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
222.0, 900.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
222.0, 975.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
309.33028001113735, 932.8915800086061

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 931.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.81326653363635, 965.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.0, 995.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.0, 1035.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.0, 1024.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 612.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 1080.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 877.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 571.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.0, 620.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 632.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 281.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.99811031059136, 324.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.71150598876994, 342.6016693351398

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
42.35933588893384, 778.2605001470506

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
76.0, 775.0

c77

c77

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
404.0, 271.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.5473041962108, 281.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.3897804297072, 171.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.64668991336424, 157.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.99954411769323, 269.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.1306830355181, 751.7110433666369

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0, 716.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
76.0, 1092.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.17940388792766, 1108.0808431967405

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.0, 1092.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
82.32345087218702, 1038.2197930558752

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
78.39199321602035, 944.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
872.0, 953.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 177.63260401303683

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 937.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
848.4946950348617, 32.00001407142656

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 707.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 341.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.0, 341.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 341.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 612.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 666.8911513906571

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 694.8629774954745

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.0, 1079.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back