1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14726496.csml convertedTime:2009.07.01.10:43

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Receptor tyrosine kinases and the regulation of macrophage activation.
Authors Correll PH, Morrison AC, Lutz MA.
Affiliation Department of Veterinary Science, The Pennsylvania State University, UniversityPark, PA 16802-3500, USA. phc7@psu.edu
Abstract
PMID 14726496
Model Abstract

Entity

G010329:TNF-alpha G010453:IFN-gamma G010514:iNOS G010539:SOCS1 G010657:IL-12 p40 G010859:B7-2 G011345:IL10 G011948:SOCS3 G012639:TWIST1 G013136:Twist2 MO000000013:RTK ligan: RTK MO000000048:AKT MO000000058:NF-kappaB MO000000215:IkappaB MO000000289:TNF-alpha MO000000306:ICAM-1 MO000013119:STAT1 MO000013122:STAT3 MO000016665:IFNgamma: IFN gamma receptor MO000016846:MSP MO000016882:LPS MO000017053:IL-4: IL-4R MO000017247:IL-10 MO000017257:PI-3K MO000017265:IL-12 MO000018841:Met MO000019704:STAT1{p} MO000019755:FGF-2: FGF-2 receptor MO000021014:NO MO000021201:iNOS MO000021607:STAT3{p} MO000021702:Gas6 MO000038797:L-arginine MO000062117:protein S MO000064501:prostaglandin E synthase 2 MO000068882:OTC MO000089992:arginase MO000101490:SR-A e1: e10: e11:ligand: Gas6 e12:ligand: protein S e13:ligand: STK e14:STK e15:InlB e16:InlB: Met e17:CR3 e18:CR3 {activated} e19:C3bi e2: e20:C3bi: CR3 {activated} e21:ICAM-1: CR3 {activated} e22:zymosan e23:LPS: CR3 {activated} e24:zymosan: CR3 {activated} e25:scavenger receptor A e26:scavenger receptor A e27:lipid A e28:lipoteichoic acid e29:lipid A: scavenger receptor A e3: e30:lipoteichoic acid: scavenger receptor A e31:lipoprotein e32:lipoprotein: scavenger receptor A e33:STK e34:SR-A {activated} e35:MSP: STK e36:cyclooxygenase-2 e37:NF-kappaB {activated} e38:phosphatidyl serine e39:phosphatidyl serine: Gas6 e4: e40:arginase e41:STAT6 e42:STAT6 {activated} e43:MHC class II e44:SOCS e45:IkappaB {p} e46:IkappaB e47:IFNgamma receptor e48:IL-4R e49:IL-4 e5:IFN gamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ligand e60: e61: e62: e63:FGF-2 receptor e64:FGF-2 e65:RTK ligand e66:RTK e67:Th2 cytokines e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p6 p7 p8 p9
Model Detail
649.0, 1173.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
374.0, 1158.0
27.0, 27.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
462.0, 822.0
28.0, 28.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
482.0, 1142.0
28.0, 28.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
512.0, 972.0
32.0, 32.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29 p33 p55

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
490.0, 998.0
28.0, 28.0

B7-2

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
616.0, 988.0
31.0, 31.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
533.0, 1157.0
30.5, 30.5

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m94757

10

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
575.0, 1059.0
26.5, 26.5

TWIST1

--

G012639

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46 p48 p49

--

true true true true

csml-variable:Double

m95335

10

false

infinite

0

unit false false false
TRANSFACG012639

--

Go back
564.0, 1012.0
32.0, 32.0

Twist2

--

G013136

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m95637

10

false

infinite

0

unit false false false
TRANSFACG013136

--

Go back
601.0, 1305.0
31.0, 31.0

RTK ligan: RTK

--

MO000000013

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000013

--

Go back
842.0, 1254.0
28.0, 28.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
795.0, 1131.0
34.0, 34.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
719.0, 1219.0
26.0, 26.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p43

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
817.0, 1177.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1006.0, 170.0
36.0, 36.0

ICAM-1

--

MO000000306

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m242

10

false

infinite

0

unit false false false
InterProIPR003987
TRANSPATHMO000000306

--

Go back
533.0, 729.0
29.0, 29.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
254.0, 570.0
28.0, 28.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
51.0, 987.0
34.0, 34.0

IFNgamma: IFN gamma receptor

--

MO000016665

cso30:c:Complex

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1018.0, 550.0
28.0, 28.0

MSP

--

MO000016846

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m1781

10

false

infinite

0

unit false false false
InterProIPR009003
TRANSPATHMO000016846

--

Go back
1002.0, 302.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p18

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
43.0, 1159.0
34.0, 34.0

IL-4: IL-4R

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
209.0, 693.0
30.0, 30.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
221.0, 1041.0
30.0, 30.0

PI-3K

--

MO000017257

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2113

10

false

infinite

0

unit false false false
InterProIPR002420
TRANSPATHMO000017257

--

Go back
311.0, 1195.0
26.0, 26.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
671.0, 99.0
34.0, 34.0

Met

--

MO000018841

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3463

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000018841

--

Go back
533.0, 769.0
30.0, 30.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
719.0, 1367.0
42.0, 42.0

FGF-2: FGF-2 receptor

--

MO000019755

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m4286

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000019755

--

Go back
477.0, 637.0
30.0, 30.0

NO

--

MO000021014

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m218100

10

false

infinite

0

unit false false false
TRANSPATHMO000021014

--

Go back
457.0, 681.0
38.0, 38.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
181.0, 561.0
30.0, 30.0

STAT3{p}

--

MO000021607

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m5950

10

false

infinite

0

unit false false false
TRANSPATHMO000021607

--

Go back
204.0, 112.0
31.0, 31.0

Gas6

--

MO000021702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p25

true true true true

csml-variable:Double

m6039

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000021702

--

Go back
554.0, 634.0
28.0, 28.0

L-arginine

--

MO000038797

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p28

true true true true

csml-variable:Double

m16983

10

false

infinite

0

unit false false false
DIP232
TRANSPATHMO000038797

--

Go back
345.0, 105.0
30.0, 30.0

protein S

--

MO000062117

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m37009

10

false

infinite

0

unit false false false
TRANSPATHMO000062117

--

Go back
387.0, 671.0
34.0, 34.0

prostaglandin E synthase 2

--

MO000064501

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

--

true true true true

csml-variable:Double

m39373

10

false

infinite

0

unit false false false
TRANSPATHMO000064501

--

Go back
624.0, 640.0
32.0, 32.0

OTC

--

MO000068882

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m43726

10

false

infinite

0

unit false false false
TRANSPATHMO000068882

--

Go back
666.0, 690.0
28.0, 28.0

arginase

--

MO000089992

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m63554

10

false

infinite

0

unit false false false
TRANSPATHMO000089992

--

Go back
566.0, 198.0
36.0, 36.0

SR-A

--

MO000101490

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m74475

10

false

infinite

0

unit false false false
TRANSPATHMO000101490

--

Go back
94.75, 108.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
103.0, 128.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
272.25, 97.0
23.934773076079807, 46.325367244025436

ligand: Gas6

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
432.25, 93.0
27.31276035957027, 52.863407147555364

ligand: protein S

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
503.25, 87.0
25.68833589125192, 49.71935978951985

ligand: STK

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
571.0, 115.0
34.5, 34.5

STK

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p17

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000045421

--

Go back
595.0, 17.25
37.59226713532512, 24.434973637961335

InlB

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
623.25, 92.0
24.933896075422055, 48.25915369436527

InlB: Met

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
734.0, 118.0
36.0, 36.0

CR3

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000017034

--

Go back
822.0, 118.0
36.0, 36.0

CR3 {activated}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000017034

--

Go back
881.0, 22.25
30.0, 19.5

C3bi

--

e19

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
94.75, 108.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
929.25, 111.0
21.793795220346414, 42.18153913615435

C3bi: CR3 {activated}

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
925.25, 232.0
29.005152378864288, 56.13900460425346

ICAM-1: CR3 {activated}

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1005.0, 426.25
30.0, 19.5

zymosan

--

e22

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
904.25, 350.0
23.159942994957245, 44.82569611927208

LPS: CR3 {activated}

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
912.25, 477.0
23.452203464152596, 45.391361543521164

zymosan: CR3 {activated}

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
902.0, 798.0
36.0, 36.0

scavenger receptor A

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p12 p14

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
Affymetrix208422_at
EnsemblENSG00000038945
HGNCMSR1
InterProIPR003543
OMIM153622
PIRA38415
PROSITEPS00420
ProteomeHumanPSD/MSR1
RefSeqNM_002445
TRANSPATHMO000116148
UnigeneHs.147635
UniProtP21757

--

Go back
737.0, 953.0
30.0, 30.0

scavenger receptor A

--

e26

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
Affymetrix1425434_a_at
EnsemblENSMUSG00000025044
MGDMsr1
ProteomeHumanPSD/Msr1
RefSeqNM_031195
TRANSFACG006438
UnigeneMm.1227

--

Go back
1034.0, 761.5
35.399495374264085, 20.059714045416317

lipid A

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1026.0, 855.5
43.271656854499575, 24.520605550883094

lipoteichoic acid

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
906.25, 722.0
26.62628809471607, 51.53475115106336

lipid A: scavenger receptor A

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
111.87518862352903, 126.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
914.25, 864.0
28.434224950668714, 55.03398377548784

lipoteichoic acid: scavenger receptor A

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1033.0, 915.5
30.0, 17.0

lipoprotein

--

e31

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
913.25, 936.0
28.556566542424903, 55.270773953080464

lipoprotein: scavenger receptor A

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
661.0, 965.0
30.5, 30.5

STK

--

e33

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p15

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSFACG013212

--

Go back
574.0, 254.0
36.0, 36.0

SR-A {activated}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000101490

--

Go back
915.5, 603.0
25.89563692172769, 50.1205875904407

MSP: STK

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
383.0, 877.0
42.56055363321799, 22.69896193771627

cyclooxygenase-2

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
807.0, 1059.0
34.0, 34.0

NF-kappaB {activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
142.0, 43.0
44.10428931875525, 24.99243061396131

phosphatidyl serine

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
98.5, 139.0
31.292260469195355, 60.565665424249076

phosphatidyl serine: Gas6

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
143.55678757705792, 156.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
383.0, 947.0
34.0, 34.0

arginase

--

e40

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p27 p30 p31

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSFACG028882

--

Go back
409.0, 1045.0
30.0, 30.0

STAT6

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
Affymetrix100962_at
EnsemblENSMUSG00000002147
InterProIPR008967
MGDMGI:103034
PROSITEPS50001
ProteomeHumanPSD/Stat6
RefSeqNM_009284
TRANSFACT08683
TRANSPATHMO000079083
UnigeneMm.121721
UniProtP52633

--

Go back
389.0, 1009.0
30.0, 30.0

STAT6 {activated}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
Affymetrix100962_at
EnsemblENSMUSG00000002147
InterProIPR008967
MGDMGI:103034
PROSITEPS50001
ProteomeHumanPSD/Stat6
RefSeqNM_009284
TRANSFACT08683
TRANSPATHMO000079083
UnigeneMm.121721
UniProtP52633

--

Go back
370.0, 1102.0
27.0, 27.0

MHC class II

--

e43

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p34 p35

--

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSFACG010240

--

Go back
599.0, 1197.0
42.30103806228373, 22.560553633217992

SOCS

--

e44

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
849.0, 1217.5
38.88, 29.159999999999997

IkappaB {p}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
575.0, 1149.0
41.31487889273357, 22.03460207612457

IkappaB

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p47

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
111.375, 1057.5
24.315026362038665, 37.40773286467488

IFNgamma receptor

--

e47

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
113.375, 1205.5
29.25, 45.0

IL-4R

--

e48

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p52

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
44.5, 1272.125
31.400000000000002, 23.549999999999994

IL-4

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p52

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
50.5, 1103.125
34.6, 25.949999999999996

IFN gamma

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
277.0, 797.0
510.81509614908845, 463.25316913334495

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
332.1718353382627, 807.9784266442831
298.6889016588712, 448.9845910286218

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
283.6586697822042, 803.1830505120466
497.49775658468053, 450.8870681092515

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
284.60990832251895, 804.1342890523615
495.59527950405055, 448.9845910286218

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
277.0, 797.0
510.81509614908845, 463.25316913334495

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
277.0, 797.0
510.81509614908845, 463.25316913334495

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
284.60990832251895, 804.1342890523615
495.59527950405055, 448.9845910286218

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
649.8855078034312, 987.2477080629751
31.91292053176827, 28.88959121823236

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
566.1765162557224, 1120.4211037070584
90.36766132991323, 81.80651446707947

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
277.0, 797.0
510.81509614908845, 463.25316913334495

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
423.0, 20.5
34.446397188049204, 22.39015817223198

ligand

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2 p3 p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
397.39624400362675, 1002.8658804704096
16.17676353109998, 7.7888120705296275

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
396.8560560796744, 979.6377997404564
55.36926220512061, 99.66467196921711

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
420.084136809628, 1044.4603506147441
8.64300678323833, 8.643006783238336

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
781.375, 1297.5
29.25, 45.0

FGF-2 receptor

--

e63

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p53

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
836.5, 1376.125
31.879999999999995, 23.909999999999997

FGF-2

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p53

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
484.0, 1373.5
31.91564147627416, 20.745166959578214

RTK ligand

--

e65

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
501.0, 1316.5
30.08, 22.559999999999995

RTK

--

e66

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p54

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
983.0, 669.5
33.00527240773287, 21.45342706502636

Th2 cytokines

--

e67

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p56

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
106.0, 114.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
109.0, 135.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
117.0, 156.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
53.0, 1049.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m63*m49*0.1

nodelay

--

true

0

false

PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.

Go back
909.0, 421.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c28 : 1

m18*m22*0.1

nodelay

--

true

0

false

PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.

Go back
697.0, 905.0
23.0, 23.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c29 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.

Go back
961.0, 757.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c34 : 1

m27*m25*0.1

nodelay

--

true

0

false

PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.

Go back
961.0, 853.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c35 : 1

m28*m25*0.1

nodelay

--

true

0

false

PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.

Go back
973.0, 949.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m25*m31*0.1

nodelay

--

true

0

false

PMID: 14726496, 11777982 MSP stimulation of primary peritoneal macrophages induces the expression of scavenger receptor A, which recognizes the exogenous ligands lipid A and lipoteichoic acid as well as oxidized low-density lipoprotein and apoptotic cells, resulting in enhanced uptake of acetylated LDL by these cells.

Go back
729.0, 993.0
27.0, 27.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c40 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14726496 Although the Tyro3 family of receptors is reported to be widely expressed by monocytes and their derivatives, expression of the STK receptor by monocyte/macrophage populations is highly regulated. PMID: 14726496, 10725742 LPS stimulation of macrophages in vitro or in vivo inhibits expression of STK.

Go back
501.0, 201.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m74475*m13*0.1

nodelay

--

true

0

false

PMID: 14726496, 11141491 STK may enhance clearance of Listeria through the activation of other PRRs, such as R-A, which has been shown to be critical in the innate response to infection with Listeria.

Go back
913.0, 549.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m14*m1781*0.1

nodelay

--

true

0

false

PMID: 14726496 MSP, the ligand for STK, was originally isolated from serum as a result of its ability to induce chemotaxis and complement-mediated phagocytosis by primary peritoneal macrophages.

Go back
513.0, 821.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c119 : 1
stoichiometry:c127 : 1
stoichiometry:c48 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively. PMID: 14726496, 10229863 Conversely, PI-3K has been shown to be a negative regulator of iNOS expression in macrophages through sustained activation of NF-kappaB.

Go back
389.0, 729.0
30.0, 30.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c52 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.

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257.0, 37.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1

m6039*m6*0.1

nodelay

--

true

0

false

PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.

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461.0, 737.0
30.0, 30.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m93479*0.1

nodelay

--

true

0

false

PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.

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481.0, 873.0
25.0, 25.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c51 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14726496, 7514598, 10586055, 12177064 MSP stimulation of primary peritoneal macrophages inhibits the production of nitric oxide (NO) and prostaglandin E2 in response to proinflammatory cytokines and LPS, as a result of an inhibition of the expression of inducible NO synthase (iNOS) and cyclooxygenase- 2, respectively.

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701.0, 1133.0
25.0, 25.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c56 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS.

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753.0, 1177.0
30.0, 30.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS.

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853.0, 1121.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c60 : 1
stoichiometry:c118 : 1
stoichiometry:c62 : 1

m37*m23*m47*0.1

nodelay

--

true

0

false

PMID: 14726496, 10092806 A deletion in the tyrosine kinase domain of the closely related Mer RTK also results in enhanced sensitivity to endotoxic shock, and macrophages from these animals produce elevated levels of tumor necrosis factor alpha (TNF-alpha) and display increased activation of NF-kappaB in response to stimulation with LPS. PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.

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137.0, 89.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m39*m6039*0.1

nodelay

--

true

0

false

PMID: 14726496, 11346799 In addition, Tyro3 receptors play a direct role in the recognition of apoptotic cells through the interaction of Gas6 with phosphatidyl serine on the surface of apoptotic cells, and macrophages from Mer knockout (KO) mice are defective in the clearance of apoptotic thymocytes.

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529.0, 689.0
30.0, 30.0

p26

p26

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m5576*m16983*0.1

nodelay

--

true

0

false

PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.

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337.0, 897.0
25.0, 25.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c75 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 14726496 MSP stimulation of the STK receptor inhibits iNOS expression in response to interferon-gamma (IFN-gamma) and LPS and induces the expression of arginase, thus favoring the metabolism of arginine to ornithine.

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585.0, 689.0
30.0, 30.0

p28

p28

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c74 : 1

m16983*m63554*0.1

nodelay

--

true

0

false

PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.

Go back
589.0, 889.0
23.0, 23.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c121 : 1
stoichiometry:c85 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.

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377.0, 49.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c5 : 1
stoichiometry:c7 : 1

m6*m37009*0.1

nodelay

--

true

0

false

PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.

Go back
313.0, 957.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 14726496 MSP stimulation of the STK receptor inhibits iNOS expression in response to interferon-gamma (IFN-gamma) and LPS and induces the expression of arginase, thus favoring the metabolism of arginine to ornithine.

Go back
317.0, 1025.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c71 : 1
stoichiometry:c79 : 1

m43*m2113*0.1

nodelay

--

true

0

false

PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS. PMID: 14726496 The ability of STK and PI-3K to induce arginase I expression in resident macrophages suggests a potential dual role for RTK signaling in limiting tissue-destructive inflammation and pro-moting the wound-healing process by tipping the balance of arginine metabolism in macrophages.

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321.0, 1065.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1

m1947*m42*m35*0.1

nodelay

--

true

0

false

PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS. PMID: 14726496, 1777982 We have shown that MSP induces expression of arginase I in primary peritoneal macrophages and cooperates with IL-4 to enhance arginase activity in a Stat6-dependent manner.

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513.0, 893.0
25.0, 25.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c87 : 1
stoichiometry:c120 : 1
stoichiometry:c84 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.

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437.0, 1077.0
25.0, 25.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c91 : 1
stoichiometry:c90 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.

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429.0, 1121.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c92 : 1

m1947*0.1

nodelay

--

true

0

false

PMID: 14726496 Pretreatment of macrophages with MSP also results in the inhibition of major histcompatibility complex (MHC) class II expression in response to IFN-gamma and IL-4 and reduced Th1/Th2 differentiation under polarizing conditions in vitro.

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617.0, 737.0
30.0, 30.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c110 : 1
stoichiometry:c97 : 1

m1357*m1639*0.1

nodelay

--

true

0

false

PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496 RTK signaling could ultimately inhibit LPS-induced NF-kappaB activation and IFN-gamma-induced Stat1 tyrosine phosphorylation through the induction of classical negative-feedback pathways.

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441.0, 1001.0
25.0, 25.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 14726496, 11452127 macrophages and dendritic cells from triple mutant mice for the RTKs Tyro3, Axl, and Mer express elevated levels of MHC class II and the costimulatory molecule B7-2 in response to LPS and produce increased levels of IL-12.

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209.0, 621.0
30.0, 30.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m1360*m2103*0.1

nodelay

--

true

0

false

PMID: 14726496 IL-10, a potent inhibitor of classical activation, induces Stat3 phosphorylation.

Go back
449.0, 1201.0
27.0, 27.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c104 : 1

m5950*0.1

nodelay

--

true

0

false

PMID: 14726496, 12538698, 10029571 IL-10 induces the expression of SOCS1 and SOCS3 in a Stat3-dependent manner.

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501.0, 33.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c8 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 14726496, 7867073, 7854420, 7939629 Consistent with the activation of nearly all RTKs, the ligands for the Tyro3 family of RTKs (Gas6 and protein S) and STK [macrophage-stimulating protein (MSP)] bind to the extracellular domain of their respective receptors, resulting in the up-regulation of kinase activity.

Go back
497.0, 1209.0
27.0, 27.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c105 : 1

m5950*0.1

nodelay

--

true

0

false

PMID: 14726496, 12538698, 10029571 IL-10 induces the expression of SOCS1 and SOCS3 in a Stat3-dependent manner.

Go back
725.0, 1037.0
25.0, 25.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 14726496 the induction of IL-10 in response to LPS may provide an important negative-feedback mechanism for limiting the extent and/or duration of this response.

Go back
549.0, 1209.0
27.0, 27.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 14726496 Several RTKs have also been shown to induce the expression of SOCS proteins, suggesting the possibility that RTK signaling could regulate macrophage activation through the induction of SOCS1 and SOCS3.

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769.0, 1217.0
30.0, 30.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c1 : 1
stoichiometry:c114 : 1

m186*m5*0.1

nodelay

--

true

0

false

PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.

Go back
769.0, 1253.0
30.0, 30.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m186*m2113*0.1

nodelay

--

true

0

false

PMID: 14726496, 10669740, 10485711 RTK signaling has been shown to activate NF-kappaB signaling in several cell types through the PI-3K- and Akt-dependent phosphorylation of IkappaB kinase.

Go back
625.0, 1025.0
23.0, 23.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c122 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14726496 Twist 1 and twist 2 are basichelix-loop-helix transcription factors that are up-regulated in response to NF-kappaB. PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.

Go back
634.0, 1058.0
27.0, 27.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c123 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14726496 Twist 1 and twist 2 are basichelix-loop-helix transcription factors that are up-regulated in response to NF-kappaB. PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.

Go back
637.0, 1133.0
25.0, 25.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14726496 Negative-feedback inhibition of the NF-kappaB signaling pathway has also been demonstrated through the up-regulation of IkappaB and more recently, the p65-dependent xpression of twist proteins.

Go back
661.0, 1101.0
27.0, 27.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c130 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.

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589.0, 1105.0
23.0, 23.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m4286*0.1

nodelay

--

true

0

false

PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.PMID: 14726496, 10825239, 11169739

Go back
647.0, 40.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m15*m3463*0.1

nodelay

--

true

0

false

PMID: 14726496, 11081636 Listeria monocytogenes has been shown to gain entry into hepatocytes through the interaction of InlB with the Met receptor.

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430.0, 1166.0
24.0, 24.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m2121*0.1

nodelay

--

true

0

false

PMID: 14726496 IL-12 has been shown to play an important role in sustaining autoimmunity in several mouse models through its ability to mediate the production of IFN-gamma and favor a Th1 response.

Go back
245.0, 1177.0
30.0, 30.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m2121*m93423*0.1

nodelay

--

true

0

false

PMID: 14726496 IL-12 has been shown to play an important role in sustaining autoimmunity in several mouse models through its ability to mediate the production of IFN-gamma and favor a Th1 response.

Go back
45.0, 1213.0
30.0, 30.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m65*m64*0.1

nodelay

--

true

0

false

PMID: 14726496, 11160269 IL-4, a potent inhibitor of NO production, accomplishes this task by up-regulating arginase expression through the activation of signal transducer and activator of transcription (Stat)6 and limiting the amount of L-arginine available to iNOS.

Go back
781.0, 1373.0
30.0, 30.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m66*m67*0.1

nodelay

--

true

0

false

PMID: 14726496, 10825239, 11169739 It is interesting that the Met RTK has been shown to induce muscle differentiation through the upregulation of twist 1 expression, and fibroblast growth factor 2 induces expression of twist 1 in osteoblasts.PMID: 14726496, 10825239, 11169739

Go back
561.0, 1353.0
30.0, 30.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m69*m68*0.1

nodelay

--

true

0

false

PMID: 14726496 Several RTKs have also been shown to induce the expression of SOCS proteins, suggesting the possibility that RTK signaling could regulate macrophage activation through the induction of SOCS1 and SOCS3.

Go back
567.0, 843.0
25.0, 25.0

p33

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c131 : 1
stoichiometry:c98 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 14726496 pretreatment of primary peritoneal macrophages with MSP for 2?4 h results in the complete inhibition of IL-12 production in response to IFN-gamma and LPS as a result of the inhibition of IL-12 p40 expression. PMID: 14726496 This inhibition appears to result from a block in Stat1 tyrosine phosphorylation and IFN consensus sequence-binding protein up-regulation induced by IFN-gamma. PMID: 14726496, 12154357 recent studies have demonstrated that PI-3K negatively regulates the production of IL-12 by dendritic cells and Th1 responses in vivo.

Go back
733.0, 665.0
30.0, 30.0

p56

p56

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 14726496 Although proinflammatory cytokines and LPS induce expression of iNOS, resulting in the metabolism of arginine to NO, T helper cell type 2 (Th2) cytokines induce expression of arginase, resulting in the production of ornithine.

Go back
737.0, 241.0
30.0, 30.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m17*m13*0.1

nodelay

--

true

0

false

PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.

Go back
881.0, 65.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m18*m19*0.1

nodelay

--

true

0

false

PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.

Go back
925.0, 173.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18*m242*0.1

nodelay

--

true

0

false

PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.

Go back
937.0, 301.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c27 : 1

m18*m155666*0.1

nodelay

--

true

0

false

PMID: 14726496 signaling through the STK receptor regulates the activation of the alphaMbeta2 integrin, complement receptor 3 (CR3), which recognizes a variety of exogenous and endogenous ligands, including C3bi, intercellular adhesion molecule-1 (ICAM-1), LPS, and zymosan.

Go back
806.1885401278914, 1243.51068238804

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.0, 36.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.88382951337417, 373.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
242.09505157597033, 598.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
206.383083722649, 598.2494651199621

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 659.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.0, 1177.0144992693706

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 1194.36345376026

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.0, 591.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
184.03061226328856, 591.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
654.3335677176674, 1013.1966833641114

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.9998684686964, 373.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0, 39.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 753.3359122635496

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 1216.019375177176

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.8592480260213, 1243.0075819419862

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.0, 1232.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0, 1232.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 1241.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0, 1243.221908914128

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
236.0, 1071.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.9235563827556, 1158.9999730644106

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.0, 843.4499096503235

c119

c119

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
671.2724472327433, 77.30007459611961

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 914.8321513577373

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
251.0, 907.5677895722437

c121

c121

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
603.8836809259548, 1031.3592553320611

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 1072.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.833070699734, 1040.6257316546619

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.9969992497068, 1072.219095869855

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.0, 799.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.5198857882975, 330.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.4278135270821, 1083.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.7824497174829, 1150.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.029062765764, 70.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.1795895597943, 1082.528950800577

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 866.0045768621495

c131

c131

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
594.4090509434968, 1093.6286613210732

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.6372109535452, 1135.1253558844041

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.0, 1182.9990241521741

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
408.95753435061243, 1174.823193208684

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.76114000116263, 1197.9402850002907

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
142.0858607382584, 1091.1925233821837

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.8975240392217, 1174.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
90.82241931261927, 1068.676232709847

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 154.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 1087.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 1029.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
60.0, 1251.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.0, 1228.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
60.0, 1201.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 1343.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 1388.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 1389.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 1338.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 1372.7354436625492

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 120.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 1341.9987028429207

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 140.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.5295573660936, 685.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.0, 680.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 160.44416820858652

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 100.65685424949238

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 42.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 95.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.0, 73.58806080808189

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.0, 145.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.0, 188.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 203.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.0, 154.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.0, 316.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 154.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 436.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.3701422443754, 331.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 451.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.0, 928.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
294.945204834583, 34.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.0, 772.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 788.9304660932648

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.0, 868.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 833.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.3531602401445, 756.1513543886333

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.1554175279994, 876.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.0, 815.7700926429702

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.6883832866965, 933.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 964.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0009936919447, 645.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.0, 67.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.4139141457872, 989.0056408699137

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.9999822862818, 374.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
539.0, 216.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 227.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0, 137.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.0, 150.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 564.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 579.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.96992470556546, 833.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 775.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 85.9294846883888

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 727.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.9986780137066, 886.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 713.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 767.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.641289004847, 635.0

c54

c54

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
509.39473607722607, 635.0

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
685.1916583936265, 1157.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 1192.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 1188.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
733.763234210589, 373.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.7165612572172, 43.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.9999981112509, 368.01823009338773

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.0, 1140.631634032896

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.8, 1099.4

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.8529642184483, 68.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.54768111720907, 111.65188796010048

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
133.93645805334322, 119.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 701.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
350.2218265365094, 372.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.2491077284276, 662.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.6568542494924, 672.6568542494924

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 79.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 662.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 1040.6600336668405

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 704.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
85.0, 910.6637446857117

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 678.1754418849364

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 922.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 965.5096012338028

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
85.0, 972.0778025443822

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
77.0, 1087.6317673582232

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 986.7200533521045

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0, 63.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.8063166161281, 1064.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 1041.1530859662623

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.89546304620546, 1027.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
263.5877209424682, 628.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
526.0, 918.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.1811873607643, 912.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0695719680247, 638.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
541.2915876024098, 637.0

c87

c87

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
612.0935726838414, 392.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
85.0, 1008.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.1675379317294, 69.10709028295291

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.4278135270821, 1095.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.8786981790998, 640.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
404.7012075212312, 1122.1659646153462

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
77.0, 1134.9032775043543

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.7770960425524, 641.0

c94

c94

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
650.6878305240239, 633.0

c95

c95

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
562.0, 745.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.5019900857897, 758.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.9340732964032, 868.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.0, 1013.3330443576974

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back