1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14751759.csml convertedTime:2009.07.01.10:44

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signal transduction pathways mediated by the interaction of CpG DNA withToll-like receptor 9.
Authors Takeshita F, Gursel I, Ishii KJ, Suzuki K, Gursel M, Klinman DM.
Affiliation Center for Biologics Evaluation and Research/Food and Drug Administration, Bldg29A, Rm 3D10, Bethesda, MD 20892, USA.
Abstract Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs"patterned after those present in bacterial DNA have characteristicimmunomodulatory effects. CpG DNA is recognized as a pathogen-associatedmolecular pattern, and triggers a rapid innate immune response. CpG ODN arebeing harnessed for a variety of therapeutic uses, including as immuneadjuvants, for cancer therapy, as anti-allergens, and as immunoprotectiveagents. The signal transduction pathway mediated by the engagement of CpG DNAwith Toll-like receptor 9 (TLR9) is shared with other members of the TLR family.Recent studies demonstrate that formation and maturation of CpG DNA-containingendosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associatedGTP-binding protein, Rab5, which are essential for the initiation ofTLR9-mediated signaling.
PMID 14751759
Model Abstract

Entity

G010228:IFN-beta G011345:IL10 G013255:TLR9 MO000000015:Raf-1 MO000000022:p38 MO000000048:AKT MO000000058:NF-kappaB MO000000078:MEK1 MO000000203:NIK MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000000276:AP-1{active} MO000004670:ERK1 MO000004676:ERK2{active} MO000007822:JNK1 MO000009393:MEK2 MO000013119:STAT1 MO000016573:MyD88 MO000016574:TAK1 MO000016660:IFNbeta MO000016665:IFNgamma MO000016882:LPS MO000016903:JNK2{active} MO000017142:PDK1 MO000017189:CREB MO000017247:IL-10 MO000017271:IP-10 MO000017612:PI3K class III MO000019397:TLR2 MO000019416:C/EBP MO000019643:Rab5 MO000021845:PI3K class I MO000042012:TLR9 MO000042032:PGN e1: e10:JNK2 e11:TLR2:PGN e12:BLPs e13:TLR2:BLPs e14:CpG DNA e15:CpG DNA: TLR9 e16: e17: e18: e19:CpG DNA:TLR9:MyD88 e2: e20:IRAK{active} e21:TRAF6{active} e22:TAK1{active} e23:JNK1{active} e24:p38{active} e25:IKK{active} e26:NIK{active} e27:IFNa R e28:IFNbeta:IFNaR e29:IFNb R e3: e30:IFNbeta:IFNbR e31:IP-10 e32:STAT1{p} e33:IKappaB:NF-KappaB e34:IKappaB{p}:NF-KappaB e35:degradants e36:AP-1 e37:C/EBP{active} e38:CREB{active} e39:Target genes e4: e40:Raf-1{active} e41:MEK1{active} e42:MEK2{active} e43:ERK1{active} e44:ERK2 e45:CSF-1 e46:Rab5:PI3K classIII e47:EEA1 e48:PIP3:EEA1 e5:TLR4:MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:TLR4:MD-2 e60: e61: e62: e63:Rab5:PIP3:EEA1 e64:PI(3,4,5)P3 e65:PDK1{active} e66:AKT{active} e67:AKT{p} e68:LY294002 e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p6 p7 p8 p9
Model Detail
329.0, 1333.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p15

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
341.0, 1265.0
30.0, 30.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
545.0, 1305.0
22.0, 22.0

TLR9

--

G013255

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45 p46

--

true true true true

csml-variable:Double

m95738

10

false

infinite

0

unit false false false
TRANSFACG013255

--

Go back
759.0, 635.0
18.0, 18.0

Raf-1

--

MO000000015

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
660.0, 664.0
16.0, 16.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
457.0, 377.0
22.0, 22.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p54

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
740.0, 1148.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p35

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
843.0, 787.0
18.0, 18.0

MEK1

--

MO000000078

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000078

--

Go back
706.0, 770.0
19.0, 19.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
495.0, 495.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
599.0, 427.0
18.0, 18.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
810.0, 842.0
20.0, 20.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p14

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
339.0, 1067.0
18.0, 18.0

AP-1{active}

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p25 p43 p56

p32 p44

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
801.0, 877.0
22.0, 22.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
757.0, 1225.0
22.0, 22.0

ERK2{active}

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p42

p43

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
451.0, 675.0
18.0, 18.0

JNK1

--

MO000007822

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m997

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007822

--

Go back
870.0, 854.0
20.0, 20.0

MEK2

--

MO000009393

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m1135

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009393

--

Go back
309.0, 589.0
22.0, 22.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
632.0, 268.0
23.0, 23.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
501.0, 645.0
22.0, 22.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
81.0, 853.0
21.0, 21.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16 p17

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
112.0, 1440.0
16.0, 16.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
267.0, 135.0
18.0, 18.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p46

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
502.0, 810.0
19.0, 19.0

JNK2{active}

--

MO000016903

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p25 p27 p30

true true true true

csml-variable:Double

m1818

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
262.0, 350.0
20.0, 20.0

PDK1

--

MO000017142

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m2019

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017142

--

Go back
295.0, 915.0
18.0, 18.0

CREB

--

MO000017189

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30 p31

true true true true

csml-variable:Double

m2057

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
85.0, 1253.0
22.0, 22.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
102.0, 634.0
20.0, 20.0

IP-10

--

MO000017271

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18 p19

--

true true true true

csml-variable:Double

m2127

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017271

--

Go back
978.0, 418.0
20.0, 20.0

PI3K class III

--

MO000017612

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m2391

10

false

infinite

0

unit false false false
TRANSPATHMO000017612

--

Go back
539.0, 211.0
17.0, 17.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
604.0, 888.0
16.0, 16.0

C/EBP

--

MO000019416

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p27 p28

true true true true

csml-variable:Double

m3981

10

false

infinite

0

unit false false false
TRANSPATHMO000019416

--

Go back
926.0, 382.0
20.0, 20.0

Rab5

--

MO000019643

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p50

true true true true

csml-variable:Double

m4180

10

false

infinite

0

unit false false false
TRANSPATHMO000019643

--

Go back
334.0, 298.0
20.0, 20.0

PI3K class I

--

MO000021845

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m6179

10

false

infinite

0

unit false false false
TRANSPATHMO000021845

--

Go back
870.0, 322.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
415.0, 143.0
18.0, 18.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
145.76395781432052, 171.8649304263902
981.1059800470013, 1424.5658830282448

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
562.0, 810.0
19.0, 19.0

JNK2

--

e10

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m10

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
465.5, 200.0
20.648541986406492, 39.96491997368998

TLR2:PGN

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
554.0, 142.5
28.576449912126524, 18.574692442882252

BLPs

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
657.5, 200.0
20.648541986406492, 39.96491997368998

TLR2:BLPs

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
706.0, 140.0
60.0, 16.0

CpG DNA

--

e14

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p4 p15 p36 p54

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
801.5, 296.0
20.356281517211137, 39.39925454944091

CpG DNA: TLR9

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
771.0, 309.0
186.0369028881343, 310.5870327878175

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
771.0, 309.0
186.0369028881343, 310.5870327878175

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
771.0, 309.0
186.0369028881343, 310.5870327878175

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
761.5, 382.0
20.28867682143513, 28.30978161130484

CpG DNA:TLR9:MyD88

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
145.76395781432052, 171.8649304263902
981.1059800470013, 1424.5658830282448

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
679.0, 495.0
18.0, 18.0

IRAK{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p7

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
587.0, 579.0
18.0, 18.0

TRAF6{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p8

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
583.0, 723.0
25.0, 25.0

TAK1{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p9 p10 p11 p13

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
403.0, 731.0
18.0, 18.0

JNK1{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p26 p29

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007822

--

Go back
768.0, 724.0
16.0, 16.0

p38{active}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p14

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
726.0, 914.0
20.0, 20.0

IKK{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p14

p22 p28 p31

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
630.0, 842.0
19.0, 19.0

NIK{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p12

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
169.5, 804.0
20.790861159929705, 31.985940246045693

IFNa R

--

e27

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p16

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
169.5, 724.0
20.621354966016224, 39.912299934224954

IFNbeta:IFNaR

--

e28

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p16

p19 p20

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
169.5, 924.0
20.790861159929705, 31.985940246045693

IFNb R

--

e29

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p17

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
165.3860774152604, 191.4870500273301
941.8617408451208, 1385.3216438263644

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
173.5, 1000.0
20.621354966016224, 39.912299934224954

IFNbeta:IFNbR

--

e30

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p17

p18 p21

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
375.0, 1219.0
50.19031141868512, 26.768166089965398

IP-10

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p18 p19

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
373.0, 629.0
22.0, 22.0

STAT1{p}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p21

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
805.5, 979.0
20.723546075654056, 25.375770704882523

IKappaB:NF-KappaB

--

e33

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p22

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
693.5, 1087.0
20.723546075654056, 25.375770704882523

IKappaB{p}:NF-KappaB

--

e34

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p22

p23

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
988.0, 1089.0
23.74497415278576, 22.95347501435956

degradants

--

e35

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p23

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
282.0, 802.0
20.0, 20.0

AP-1

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p25 p43 p56

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
615.0, 1059.0
18.0, 18.0

C/EBP{active}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p27 p28

p34

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000019416

--

Go back
459.0, 1019.0
18.0, 18.0

CREB{active}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p30 p31

p33

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
474.0, 1220.0
43.13148788927336, 23.003460207612456

Target genes

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32 p33 p34 p35

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
201.68699867699956, 225.8257593289751
869.2598983216434, 1316.6442252230731

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
951.0, 659.0
18.0, 18.0

Raf-1{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37 p38

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000015

--

Go back
927.0, 827.0
18.0, 18.0

MEK1{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p39 p41

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000078

--

Go back
946.0, 922.0
20.0, 20.0

MEK2{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p40 p42

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009393

--

Go back
793.0, 1037.0
22.0, 22.0

ERK1{active}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p40

p56

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
873.0, 1165.0
22.0, 22.0

ERK2

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p42

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
98.0, 1352.5
20.0, 15.0

CSF-1

--

e45

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p46

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
779.0, 442.0
17.5524861878453, 19.50276243093922

Rab5:PI3K classIII

--

e46

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p47

p57

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
889.5, 581.0
13.998792513584222, 22.70074461662306

EEA1

--

e47

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p49

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
834.0, 601.0
19.59116022099448, 21.76795580110497

PIP3:EEA1

--

e48

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p49

p50

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
266.5, 205.0
18.28211964672554, 22.38626895517413

TLR4:MD-2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
273.4410383916365, 1073.4103588930116
429.53292031075847, 389.53916609187996

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
319.8337932855359, 1082.6418708285164
251.16077649455923, 377.5410398262161

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
279.04016398227947, 1078.6095469414654
418.33466912947256, 379.14078999497093

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
279.84003906665686, 1079.409422025843
416.73491896071687, 377.5410398262161

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
273.4410383916365, 1073.4103588930116
429.53292031075847, 389.53916609187996

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
273.4410383916365, 1073.4103588930116
429.53292031075847, 389.53916609187996

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
279.84003906665686, 1079.409422025843
416.73491896071687, 377.5410398262161

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
586.9920714676459, 1233.3853757685256
26.834856790635715, 24.292607199943895

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
516.603064042419, 1345.3678875813875
75.98813301586979, 68.78925725647159

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
273.4410383916365, 1073.4103588930116
429.53292031075847, 389.53916609187996

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
365.5, 201.0
21.46448889704533, 29.950449623784184

LPS:TLR4:MD-2

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
374.6795308934926, 1246.518345515615
13.602676453911897, 6.549436811142773

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
374.22529902321094, 1226.9863750935056
46.55876670386458, 83.8057800669562

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
393.75726944531993, 1281.4941995272977
7.267709924505677, 7.2677099245056755

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
762.5, 547.0
18.197467425215635, 25.39181501192879

Rab5:PIP3:EEA1

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p50

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
414.0, 346.0
11.97848456501403, 27.64265668849392

PI(3,4,5)P3

--

e64

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p51 p57

p49 p52

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
270.0, 406.0
20.0, 20.0

PDK1{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017142

--

Go back
269.0, 493.0
22.0, 22.0

AKT{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

--

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
393.0, 481.0
22.0, 22.0

AKT{p}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p55

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
91.0, 460.0
42.287636669470146, 23.96299411269975

LY294002

--

e68

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
156.6542593673953, 188.59749615619026
962.1593041623132, 1363.354881174643

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
162.09167311488193, 229.65939238859642
923.0108853522349, 1340.2118055314443

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
154.25810977484625, 232.16524869553595
900.4269727074443, 1296.1913034540576

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
330.0, 134.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882

e5 e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 14751759,10549626 For example, lipopolysaccaride (LPS) present in the surface membrane of Gram-negative bacteria engages the TLR4/MD-2 complex, while peptidoglycan (PGN) and bacterial lipoproteins (BLPs) present in the cell wall of Gram-positive bacteria engage TLR2

Go back
502.0, 762.0
19.0, 19.0

p9

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e10

MO000016903

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m22*m10*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1.

Go back
658.0, 722.0
19.0, 19.0

p9

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 MO000000022

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m22*m24*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1.

Go back
726.0, 842.0
19.0, 19.0

p9

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e26

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c39 : 1
stoichiometry:c36 : 1

m207*m27*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1. PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways

Go back
631.0, 771.0
17.0, 17.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e22 MO000000203

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m22*m174*0.1

nodelay

--

true

0

false

PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways

Go back
771.0, 779.0
17.0, 17.0

p13

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e24 MO000000248

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m25*m207*0.1

nodelay

--

true

0

false

PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1.

Go back
286.0, 854.0
19.0, 19.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010228 e14

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m93217*m14*0.1

nodelay

--

true

0

false

PMID: 14751759,12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
82.0, 758.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016660 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m1636*m28*0.1

nodelay

--

true

0

false

PMID: 14751759, 12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
82.0, 930.0
19.0, 19.0

p16

p17

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016660 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m1636*m30*0.1

nodelay

--

true

0

false

PMID: 14751759, 12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
245.0, 945.0
21.0, 21.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e31 e30

MO000017271

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m32*m31*0.1

nodelay

--

true

0

false

PMID: 14751759,12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
333.0, 733.0
21.0, 21.0

p18

p19

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e31 e28

MO000017271

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m32*m29*0.1

nodelay

--

true

0

false

PMID: 14751759,12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
498.0, 142.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000019397

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 14751759,10549626 For example, lipopolysaccaride (LPS) present in the surface membrane of Gram-negative bacteria engages the TLR4/MD-2 complex, while peptidoglycan (PGN) and bacterial lipoproteins (BLPs) present in the cell wall of Gram-positive bacteria engage TLR2

Go back
242.0, 630.0
19.0, 19.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e28 MO000013119

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m29*m1357*0.1

nodelay

--

true

0

false

PMID: 14751759,12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
234.0, 806.0
19.0, 19.0

p20

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e30 MO000013119

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m31*m1357*0.1

nodelay

--

true

0

false

PMID: 14751759,12356687 In macrophages, CpG DNA also induces IFN-b production, which then upregulates STAT1 phosphorylation and IP-10 production through IFN-a/b receptor in an autocrine manner

Go back
806.0, 914.0
19.0, 19.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e25 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m26*m35*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1. PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways

Go back
845.0, 1089.0
21.0, 21.0

p23

p23

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e34

MO000000058 e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1. PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
418.0, 786.0
19.0, 19.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e36

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1. PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
522.0, 878.0
19.0, 19.0

p24

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016903 e36

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m1818*m38*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1. PMID: 14751759,10601019,11971021,10623843 The TLR9 signaling cascade involves mitogen-activated protein kinases (MAPKs), such as p38, c-Jun NH2-terminal kinase (JNK), extracellular receptor kinase (ERK), and NF-kB-inducing kinase (NIK)-IKK-IkB pathways PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
531.0, 927.0
18.0, 18.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e23 MO000019416

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m23*m3981*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
603.0, 983.0
18.0, 18.0

p26

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016903 MO000019416

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m1818*m3981*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
671.0, 975.0
18.0, 18.0

p26

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e25 MO000019416

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m26*m3981*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
371.0, 875.0
18.0, 18.0

p26

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e23 MO000017189

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m23*m2057*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
630.0, 142.0
19.0, 19.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3964*m12*0.1

nodelay

--

true

0

false

PMID: 14751759,10549626 For example, lipopolysaccaride (LPS) present in the surface membrane of Gram-negative bacteria engages the TLR4/MD-2 complex, while peptidoglycan (PGN) and bacterial lipoproteins (BLPs) present in the cell wall of Gram-positive bacteria engage TLR2

Go back
459.0, 907.0
18.0, 18.0

p26

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016903 MO000017189

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m1818*m2057*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
515.0, 987.0
18.0, 18.0

p26

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e25 MO000017189

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m26*m2057*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
422.0, 1130.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000276

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m219*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
482.0, 1134.0
19.0, 19.0

p32

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
542.0, 1138.0
19.0, 19.0

p32

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
570.0, 1198.0
19.0, 19.0

p32

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 14751759,11971021,9799232,10940886,10602032 The signaling cascade culminates in the activation of several transcription factors including NF-kB, activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and cAMP-responsive element-binding protein (CREB), which directly upregulate cytokine/chemokine gene expression

Go back
830.0, 658.0
19.0, 19.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000015 e14

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c101 : 1
stoichiometry:c103 : 1

m42*m14*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
882.0, 738.0
19.0, 19.0

p36

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e40 MO000000078

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m43*m70*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
946.0, 742.0
19.0, 19.0

p36

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000009393 e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m1135*m43*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
854.0, 978.0
19.0, 19.0

p36

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000004670 e41

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m549*m44*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
801.0, 137.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000042012

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m19828*0.1

nodelay

--

true

0

false

PMID: 14751759,11564765 Our lab demonstrated that CpG recognition in humans is also mediated by TLR9

Go back
1002.0, 998.0
19.0, 19.0

p36

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e42 MO000004670

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m45*m549*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
886.0, 1066.0
19.0, 19.0

p36

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e41 e44

MO000004676

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m44*m47*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
950.0, 1166.0
19.0, 19.0

p36

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e42 e44

MO000004676

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m45*m47*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
338.0, 994.0
19.0, 19.0

p36

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e36 MO000004676

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m38*m554*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
236.0, 1188.0
23.0, 23.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

MO000000276 G011345

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m219*m94230*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
449.0, 1337.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 14751759, 11564765 Upon IFNg treatment, both TLR9 mRNA expression and responsiveness to CpG DNA are up-regulated in PBMC

Go back
442.0, 1274.0
19.0, 19.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882 e45

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 14751759,11947920,11751985 LPS also up-regulates mTLR9 mRNA expression in RAW264.7 macrophages, while colony stimulating factor-1 down-regulates constitutive mRNA expression in bone marrow-derived macrophages

Go back
857.0, 425.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000019643 MO000017612

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m4180*m2391*0.1

nodelay

--

true

0

false

PMID: 14751759 Indeed, Rab5-mediated recruitment of class III PI3K (PI3K (III)) leads to the production of PI(3)P in the endosomal membrane, which binds to the FYVE domain of early endosome antigen 1 (EEA1), recruiting it on to the membrane.

Go back
861.0, 521.0
21.0, 21.0

p47

p49

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e47 e64

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c162 : 1
stoichiometry:c140 : 1

m63*m67*0.1

nodelay

--

true

0

false

PMID: 14751759 Indeed, Rab5-mediated recruitment of class III PI3K (PI3K (III)) leads to the production of PI(3)P in the endosomal membrane, which binds to the FYVE domain of early endosome antigen 1 (EEA1), recruiting it on to the membrane.

Go back
674.0, 330.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e15

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m1572*m15*0.1

nodelay

--

true

0

false

PMID: 14751759 TLR9-mediated signaling proceeds through MyD88, an adaptor protein recruited to the TIR, which then activates the IRAK1-TRAF6-TAK1 pathway PMID: 14751759 The signal initiates with the recruitment of MyD88 to the TIR, which then activates IRAK-TRAF6-TAK1 complex.

Go back
818.0, 530.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e48 MO000019643

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m64*m4180*0.1

nodelay

--

true

0

false

PMID: 14751759,10891392,12061891,9852157 The recruited EEA1 also associates with Rab5 and regulates homotypic fusion and trafficking of early endosomes

Go back
410.0, 298.0
19.0, 19.0

p51

p51

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

MO000021845

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m6179*0.1

nodelay

--

true

0

false

PMID: 14751759,10485710,10698680 The PI(3, 4, 5)P3, product of class I PI3K (PI3K (I)), has been demonstrated to activate a signaling cascade consisting of 3prime-phosphoinositide-dependent kinase-1 (PDK1) and the protein kinase Akt/protein kinase B (AKT/PKB)

Go back
330.0, 350.0
19.0, 19.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e64 MO000017142

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m67*m2019*0.1

nodelay

--

true

0

false

PMID: 14751759,10485710,10698680 The PI(3, 4, 5)P3, product of class I PI3K (PI3K (I)), has been demonstrated to activate a signaling cascade consisting of 3prime-phosphoinositide-dependent kinase-1 (PDK1) and the protein kinase Akt/protein kinase B (AKT/PKB)

Go back
361.0, 405.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e65 MO000000048

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m68*m69*0.1

nodelay

--

true

0

false

PMID: 14751759,10485710,10698680 The PI(3, 4, 5)P3, product of class I PI3K (PI3K (I)), has been demonstrated to activate a signaling cascade consisting of 3prime-phosphoinositide-dependent kinase-1 (PDK1) and the protein kinase Akt/protein kinase B (AKT/PKB)

Go back
457.0, 437.0
21.0, 21.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e14 MO000000048 e68

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m14*m69*0.1

nodelay

--

true

0

false

PMID: 14751759,11751939 CpG DNA also induces phosphorylation of AKT/PKB thereby inhibiting apoptosis in DCs, an effect that is reversed by a PI3K inhibitor, LY294002

Go back
103.0, 555.0
17.0, 17.0

p55

p55

cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_

cso30:i:CC_Cytoplasm

--

e67

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14751759,11751939 CpG DNA also induces phosphorylation of AKT/PKB thereby inhibiting apoptosis in DCs, an effect that is reversed by a PI3K inhibitor, LY294002

Go back
258.0, 1026.0
19.0, 19.0

p36

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e43 e36

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m46*m38*0.1

nodelay

--

true

0

false

PMID: 14751759 Raf1-MEK1/2-ERK1/2-AP-1 pathway is involved in CpG DNA-induced IL-10 production inmacrophages.

Go back
475.0, 299.0
17.0, 17.0

p48

p57

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

e46

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 14751759 Indeed, Rab5-mediated recruitment of class III PI3K (PI3K (III)) leads to the production of PI(3)P in the endosomal membrane, which binds to the FYVE domain of early endosome antigen 1 (EEA1), recruiting it on to the membrane.

Go back
677.0, 425.0
21.0, 21.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 MO000000213

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*m184*0.1

nodelay

--

true

0

false

PMID: 14751759 TLR9-mediated signaling proceeds through MyD88, an adaptor protein recruited to the TIR, which then activates the IRAK1-TRAF6-TAK1 pathway PMID: 14751759 The signal initiates with the recruitment of MyD88 to the TIR, which then activates IRAK-TRAF6-TAK1 complex.

Go back
586.0, 494.0
19.0, 19.0

p6

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000212

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m20*m183*0.1

nodelay

--

true

0

false

PMID: 14751759 TLR9-mediated signaling proceeds through MyD88, an adaptor protein recruited to the TIR, which then activates the IRAK1-TRAF6-TAK1 pathway PMID: 14751759 The signal initiates with the recruitment of MyD88 to the TIR, which then activates IRAK-TRAF6-TAK1 complex.

Go back
586.0, 646.0
19.0, 19.0

p6

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 MO000016574

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m21*m1573*0.1

nodelay

--

true

0

false

PMID: 14751759 TLR9-mediated signaling proceeds through MyD88, an adaptor protein recruited to the TIR, which then activates the IRAK1-TRAF6-TAK1 pathway PMID: 14751759 The signal initiates with the recruitment of MyD88 to the TIR, which then activates IRAK-TRAF6-TAK1 complex.

Go back
495.0, 731.0
17.0, 17.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007822 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m997*m22*0.1

nodelay

--

true

0

false

PMID: 14751759 This leads to the activation of both MAPKs (JNK1/2 and P38) and IKK complex, culminating upregulation of transcription factors including NF-kB and AP-1.

Go back
285.0, 144.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 148.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.6976483665949, 1211.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 156.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
777.0, 647.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 668.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.189873408111, 677.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.0, 763.145770236779

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 757.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.0, 767.6233495239067

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 761.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.3688381328672, 677.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.7486522501083, 165.51298281696256

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 899.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.6568542494924, 997.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.4246907579123, 845.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
963.0, 942.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
823.0, 895.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.8557517824734, 1010.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.3209810890554, 845.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.9975603804354, 1085.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
885.0, 1092.9382230137094

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 942.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.0, 158.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 1176.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.6286613210731, 1179.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 822.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 1013.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0023222977243, 1012.8687830694927

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
263.01965504718964, 1085.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.4187375300114, 1212.774914504033

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
114.37952790641047, 1205.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 1353.2702655387275

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 1322.5298221281348

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 291.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 153.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.0, 1287.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
118.0, 1286.8677218312746

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
884.7203150221502, 398.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.9856387637262, 429.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.8446454055273, 438.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0364508500504, 549.4013489469979

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.8686389671598, 318.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.6825973242131, 542.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.7988760535901, 556.795129565557

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.7352760232803, 402.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.5476811172091, 544.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 308.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 317.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 360.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
282.0, 360.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.7999954687553, 369.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
290.0, 416.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
693.0, 346.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.67655185320115, 391.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.77934149850597, 426.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.3293918553957, 156.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
468.0, 399.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.58317520481955, 455.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
133.0, 449.2709809672648

c155

c155

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
123.88471910789798, 495.0

c156

c156

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
284.9978375455748, 1036.18599622199

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.8577715147383, 822.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 1040.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.2436714876709, 401.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.22938972146386, 315.42577352654735

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
432.19728960114014, 315.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 362.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 436.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 446.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 504.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
290.30789736262074, 153.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 504.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 513.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 597.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 656.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 665.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 693.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 740.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.9928681081361, 737.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.9898173315198, 748.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0, 781.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 153.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.2320934821033, 784.016075241693

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 733.319744306791

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 680.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 732.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 748.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.0, 852.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 861.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 780.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 788.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 852.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 152.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 740.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.2664073870042, 802.7674048207653

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.4522509287157, 796.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.796029752168, 880.9602975216799

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
110.0, 864.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
306.18896515038364, 156.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
92.0, 785.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
107.87747020339849, 777.0866127295557

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
101.0, 749.1238498047111

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
92.0, 874.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.1159660434203, 167.85994340570036

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
109.0, 940.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
101.0, 948.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.70052805356016, 973.0926787693236

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
120.3461300074088, 661.266595762358

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.0, 971.2929730966948

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.9228304734869, 761.9465957439147

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
129.34593795503514, 651.1681533360578

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 744.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
190.0, 655.5538553641524

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
267.91023120718745, 607.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.5037553862376, 161.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
261.0, 640.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 832.680491366532

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
250.63417408823983, 611.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 657.2666237010624

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 924.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
816.0, 941.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.2950039375453, 933.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.0, 1100.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.9195078950523, 1106.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.0, 1100.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 163.77218936324496

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 797.9585612815268

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.17447290944057, 805.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 829.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
302.0, 815.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.5891147065071, 897.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 749.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.9692176736302, 900.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 945.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 829.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 904.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.0, 152.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 1001.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.5137101279801, 934.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.0, 904.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.4376015698018, 993.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.73544366254924, 749.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 892.6753833509902

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 893.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.352465419694, 829.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 916.4376995736171

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 925.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 161.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.5696279244778, 927.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 927.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.923410283849, 1001.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 1083.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.0, 1149.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 1037.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
492.0, 1153.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.3570969743776, 1077.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.4376015698018, 1157.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.7074115601451, 1163.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back