1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/1492121.csml convertedTime:2009.07.02.15:35

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Activation of lymphokine genes in T cells: role of cis-acting DNA elements thatrespond to T cell activation signals.
Authors Arai N, Naito Y, Watanabe M, Masuda ES, Yamaguchi-Iwai Y, Tsuboi A, Heike T,Matsuda I, Yokota K, Koyano-Nakagawa N, et al.
Affiliation DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA.
Abstract Activation of T cells is initiated by the recognition of antigen on antigenpresenting cells to exert the effector functions in immune and inflammatoryresponses. Two types of helper T cell (Th) clones (Th1 and Th2) are defined onthe basis of different patterns of cytokine (lymphokine) secretion. Theydetermine the outcome of an antigenic response toward humoral or cell-mediatedimmunity. Although lymphokine genes are coordinately regulated upon antigenstimulation, they are regulated by the mechanisms common to all as well as thosewhich are unique to each gene. For most lymphokine genes, a combination ofphorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores(A23187) is required for their maximal induction. Yet phorbol ester alone orcalcium ionophore alone produce several lymphokines. The production of thegranulocyte-macrophage colony stimulating factor (GM-CSF) is completelydependent on the two signals. We have previously found a cis-acting regionspanning the GM-CSF promoter region (positions -95 to +27) that confersinducibility to reporter genes in transient transfection assays. Furtheranalysis identified three elements required for efficient induction, referred toas GM2, GC-box and conserved lymphokine element (CLE0). GM2 defines a bindingsite for protein(s) whose binding is inducible by PMA. One protein, NF-GM2 issimilar to the transcription factor NF-kB. GC-box is a binding site forconstitutively bound proteins. CLEO defines a binding site for protein(s) whoseoptimum binding is stimulated by PMA and A23187. Viral trans-activators such asTax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV)proteins are other agents which activate lymphokine gene expression by bypassingT cell receptor (TCR) mediated signaling. The trans-activation domain of E2 andTax is interchangeable although they have no obvious sequence homology betweenthem. The viral trans-activators appear to target specific DNA binding proteinsuch as NF-kB and Sp1 to cis-acting DNA site and promote lymphokine geneexpression without TCR-mediated stimulation.
PMID 1492121
Model Abstract

Entity

e1: e10: e11:antigen:TCR:CD3 e12:TCR:CD3 e13:MHC e14:lck e15:lck{p} e16:FYN e17:FYN{p} e18:PIP2 e19:IP3 e2: e20:DAG e21:Ca2+ e22:p21ras e23:p21ras{active} e24:PKC e25:PKC{active} e26:PMA e27:A23187 e28:IL2 e29:IL2 e3: e30:GMCSF e31:GMCSF e32:IL5 e33:IL5 e34:IL6 e35:IL6 e36:IL10 e37:IL10 e38:IL3 e39:IL3 e4: e40:IL4 e41:IL4 e42:IFN-gamma e43:IFN-gamma e44:CsA e45:PGE2 e46:forskolin e47:cholera toxin e48:GMCSF e49:NF-GM2 e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:antigen:MHC e60: e61: e62: e63:NF-GM2:GMCSF e64:IkappaB:NF-kappaB e65:Nf-kappaB e66:IkappaB e67:Nf-kappaB e68:H2O2 e69:TNF-beta e7: e70:TNF-beta e71:TNF-beta:TNFRbeta e72:IL1 e73:IL1:IL1R e74:IL1R e75:Ets-1 e76:Ets-1{p} e77:Ets2 e78:Ets2{p} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p5 p6 p7 p8 p9
Model Detail
267.6137825760502, 20.567629860243915
952.9124736620228, 1414.797541545276

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
325.6820313443719, 119.0
868.4367232904099, 1249.1659700109265

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1163.5, 344.9068541300527
41.01054481546572, 63.09314586994728

antigen:TCR:CD3

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1160.5, 190.0
39.0, 60.0

TCR:CD3

--

e12

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1273.5, 287.7768014059754
37.195079086115996, 57.2231985940246

MHC

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

p1

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1081.0, 120.07436103843835
37.9875226403703, 23.42563896156168

lck

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1018.0, 177.53658536585368
36.82926829268293, 29.463414634146346

lck{p}

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1084.0, 348.58875025155965
48.504729321795125, 29.911249748440333

FYN

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1026.0, 418.07317073170736
43.658536585365866, 34.92682926829268

FYN{p}

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
902.0, 43.0
60.0, 34.0

PIP2

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
810.0, 111.0
60.0, 34.0

IP3

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
267.6137825760502, 20.567629860243915
952.9124736620228, 1414.797541545276

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
970.0, 111.0
60.0, 34.0

DAG

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
867.5, 270.80144047450926
33.62858353339926, 34.19855952549075

Ca2+

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1120.0, 469.02000000000004
40.64, 30.480000000000008

p21ras

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1113.0, 589.4599999999999
38.72, 29.04

p21ras{active}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
731.0, 96.75477963372907
49.857114107466295, 30.74522036627088

PKC

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p8

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
556.0, 97.47484403300456
47.06782048701953, 29.025155966995374

PKC{active}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
382.0, 163.0
60.0, 34.0

PMA

--

e26

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
466.0, 263.0
60.0, 34.0

A23187

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
638.0, 838.3737024221452
51.79930795847751, 27.626297577854675

IL2

--

e28

cso30:c:mRNA

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
351.0, 752.66
41.120000000000005, 30.840000000000003

IL2

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12 p13 p33

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
286.6720320492907, 40.05519930301641
914.7959747155418, 1375.8224026597325

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
753.0, 865.6539792387543
53.14878892733564, 28.34602076124568

GMCSF

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1063.0, 780.6579794727309
50.01408734151741, 30.842020527269064

GMCSF

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16 p17

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
486.0, 924.3598615916954
44.325259515570934, 23.640138408304498

IL5

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
341.0, 901.5396458039846
45.341114912457236, 27.960354196015295

IL5

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
588.0, 955.0622837370241
48.63321799307958, 25.93771626297578

IL6

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
349.0, 1010.1800000000001
37.760000000000005, 28.319999999999993

IL6

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
652.0, 1103.643598615917
47.54325259515571, 25.356401384083046

IL10

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
379.0, 1115.162910042262
42.70879452606158, 26.337089957737977

IL10

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
695.0, 1014.204152249135
50.24221453287197, 26.795847750865054

IL3

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1076.0, 869.4472730931777
48.73415174079292, 30.052726906822297

IL3

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
321.92979357478566, 74.15844582786792
844.2804516645523, 1307.6159096100287

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
801.0, 993.1557093425605
54.083044982698965, 28.844290657439448

IL4

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1085.0, 983.0187090739008
21.658559401309635, 49.98129092609916

IL4

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
753.0, 1111.6955017301038
45.57093425605536, 24.304498269896197

IFN-gamma

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1080.0, 1051.6446971221571
40.30589655866372, 24.85530287784262

IFN-gamma

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29 p35

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
907.0, 573.761984861228
49.83179142136249, 28.23801513877208

CsA

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
862.0, 447.0
60.0, 34.0

PGE2

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
803.0, 397.63330529857024
50.05887300252313, 28.366694701429775

forskolin

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p32 p33 p34 p35

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
618.0, 375.0
60.0, 34.0

cholera toxin

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p32 p33 p34 p35

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
574.0, 1173.5
60.0, 13.0

GMCSF

--

e48

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p36

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
579.5, 1116.3766038993501
32.359106815530744, 39.62339610064989

NF-GM2

--

e49

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p36

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1279.5, 161.0
137.57438113579784, 198.90271971440652

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
428.87076309221044, 718.153559012731
581.7801011864606, 539.4959720948132

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
491.7073475778989, 730.9388292475994
340.1842677328656, 522.8790530364511

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
436.4544888060005, 725.354223938021
566.6126497588812, 525.0946422442328

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
437.5378781936849, 726.4620185419117
564.4458709835123, 522.8790530364511

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
428.87076309221044, 718.153559012731
581.7801011864606, 539.4959720948132

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
428.87076309221044, 718.153559012731
581.7801011864606, 539.4959720948132

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
437.5378781936849, 726.4620185419117
564.4458709835123, 522.8790530364511

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
853.5594030644497, 939.7124797908883
36.346424128994, 33.644277332975456

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
758.2211369482329, 1094.8037243355993
102.921991830007, 95.27033593460769

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
428.87076309221044, 718.153559012731
581.7801011864606, 539.4959720948132

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1272.5, 198.0
31.0, 60.0

antigen:MHC

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
565.9930594905469, 957.90111111975
18.424120968511808, 9.070704788302617

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
565.3778259404304, 930.8501229597622
63.06143888690596, 116.0676119887837

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
591.8328685954258, 1006.341252708565
9.843736801858482, 10.065483966506982

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
754.0, 1171.5
60.0, 17.0

NF-GM2:GMCSF

--

e63

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
594.5, 1274.0
43.0, 60.0

IkappaB:NF-kappaB

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p37 p39 p40 p42

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
943.5, 1215.9068488585237
33.55940676553907, 41.093151141476426

Nf-kappaB

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1069.5, 1304.668746226605
28.570939826926946, 46.331253773395055

IkappaB

--

e66

cso30:c:Protein

cso30:i:CC_Extracellular

--

p37 p39 p40 p42

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
863.5, 1039.9068488585237
33.55940676553907, 41.093151141476426

Nf-kappaB

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
380.0, 1241.5
47.5, 28.5

H2O2

--

e68

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1302.0, 1076.5
60.0, 39.0

TNF-beta

--

e69

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
293.61593998739806, 85.0
821.2242417759129, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1164.5, 1066.0
39.0, 60.0

TNF-beta

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1164.5, 1190.0
31.0, 60.0

TNF-beta:TNFRbeta

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
90.0, 1148.5
60.0, 39.0

IL1

--

e72

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p43

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
284.5, 1234.0
31.0, 60.0

IL1:IL1R

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
280.5, 1118.0
39.0, 60.0

IL1R

--

e74

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p43

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
440.0, 496.69299657878844
48.335681223586235, 29.80700342121151

Ets-1

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p44 p46

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
425.0, 641.609756097561
45.48780487804878, 36.39024390243902

Ets-1{p}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44 p46

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
974.0, 483.8292412960354
49.73636546588851, 30.67075870396458

Ets2

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45 p47

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1007.0, 611.0243902439024
41.21951219512195, 32.975609756097555

Ets2{p}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45 p47

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
259.54984863042415, 144.0
787.8102006551206, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
267.37360501182707, 165.0
784.2134149481395, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1233.0, 217.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c114 : 1
stoichiometry:c3 : 1
stoichiometry:c1 : 1

m6*m12*0.1

nodelay

--

true

0

false

PMID:1492121 The antigen signal received by the T cell receptor (TCR)/CD3 complex is transmitted to the nucleus.

Go back
665.0, 777.0
22.0, 22.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c91 : 1
stoichiometry:c28 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
612.0, 780.0
23.0, 23.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c90 : 1
stoichiometry:c30 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
429.0, 793.0
21.0, 21.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c35 : 1
stoichiometry:c88 : 1
stoichiometry:c33 : 1

m28*m25*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
417.0, 833.0
21.0, 21.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c37 : 1
stoichiometry:c89 : 1
stoichiometry:c36 : 1

m28*m21*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
732.0, 792.0
23.0, 23.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c86 : 1
stoichiometry:c38 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
796.0, 796.0
23.0, 23.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c87 : 1
stoichiometry:c39 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1001.0, 721.0
21.0, 21.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c46 : 1
stoichiometry:c84 : 1
stoichiometry:c44 : 1

m30*m21*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1000.0, 796.0
23.0, 23.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c47 : 1
stoichiometry:c85 : 1
stoichiometry:c45 : 1

m30*m25*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals. An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
555.0, 879.0
26.0, 26.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
392.0, 864.0
23.0, 23.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m32*m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
1088.0, 180.0
23.0, 23.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m14*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 1848158 Tyrosine kinases such as lck and fyn have received attention as molecules which may play an important role in coupling the TCR to signal transduction machinery downstream.

Go back
600.0, 888.0
23.0, 23.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
356.0, 956.0
23.0, 23.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c55 : 1

m34*m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
663.0, 959.0
25.0, 25.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c58 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
375.0, 1059.0
25.0, 25.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c62 : 1
stoichiometry:c60 : 1

m36*m26*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10).

Go back
709.0, 889.0
21.0, 21.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c78 : 1
stoichiometry:c63 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1019.0, 871.0
25.0, 25.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c79 : 1
stoichiometry:c65 : 1

m38*m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
816.0, 928.0
23.0, 23.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c80 : 1
stoichiometry:c68 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1034.0, 998.0
19.0, 19.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c72 : 1
stoichiometry:c81 : 1
stoichiometry:c70 : 1

m40*m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
779.0, 1055.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c83 : 1
stoichiometry:c73 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1036.0, 1052.0
23.0, 23.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c82 : 1
stoichiometry:c75 : 1

m42*m27*0.1

nodelay

--

true

0

false

PMID: 1492121 certain cytokines are activated by phorbol esters alone (IL-5, IL-6 and IL-10 ) or Ca 2 + ionophore alone (IL-3, IL-4 and IFN-gamma). An immunosuppressive agent, cyclosporin A (CsA), almost completely inhibits production of those cytokines (IL-2, IL-3, IL-4, GM-CSF or IFN-7) whose expression depends on a calcium signal when T cells are activated by PMA/A23187 or antiCD3 antibody.

Go back
1096.0, 424.0
23.0, 23.0

p3

p3

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m16*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 1848158 Tyrosine kinases such as lck and fyn have received attention as molecules which may play an important role in coupling the TCR to signal transduction machinery downstream.

Go back
676.0, 892.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c92 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 1492121 PGE2 inhibits the expression of IL-3 and GM-CSF in Thl clone but not in Th2 clone

Go back
769.0, 777.0
21.0, 21.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c94 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 1492121 PGE2 inhibits the expression of IL-3 and GM-CSF in Thl clone but not in Th2 clone

Go back
635.0, 751.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c101 : 1
stoichiometry:c104 : 1
stoichiometry:c96 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 1492121, 1845802, 2162906 PGE2, forskolin and cholera toxin, known to elevate cAMP levels, inhibit IL-2 and IFN-gamma production.

Go back
452.0, 744.0
23.0, 23.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c98 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 1492121, 1845802, 2162906 PGE2, forskolin and cholera toxin, known to elevate cAMP levels, inhibit IL-2 and IFN-gamma production.

Go back
735.0, 1059.0
26.0, 26.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c112 : 1
stoichiometry:c105 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 1492121, 1845802, 2162906 PGE2, forskolin and cholera toxin, known to elevate cAMP levels, inhibit IL-2 and IFN-gamma production.

Go back
1005.0, 1117.0
21.0, 21.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c107 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 1492121, 1845802, 2162906 PGE2, forskolin and cholera toxin, known to elevate cAMP levels, inhibit IL-2 and IFN-gamma production.

Go back
679.0, 1167.0
26.0, 26.0

p36

p36

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m49*m48*0.1

nodelay

--

true

0

false

PMID: 1492121 Thus a 10 base pairs sequence from position -91 to -82 of the GM2 motif of the GM-CSF promoter was defined as the binding site for the NF-GM2.

Go back
876.0, 1312.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c123 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m64*m26*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 The activation of cytoplasmic NF-kappaB is thought to be mediated by its signal-dependent release from an inhibitory protein designated IkappaB allowing NF-kappaB to translocate to the nucleus and to bind to the kappaB element. NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
947.0, 1139.0
26.0, 26.0

p38

p38

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 1492121 The activation of cytoplasmic NF-kappaB is thought to be mediated by its signal-dependent release from an inhibitory protein designated IkappaB allowing NF-kappaB to translocate to the nucleus and to bind to the kappaB element.

Go back
820.0, 1260.0
23.0, 23.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c127 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m64*m68*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
902.0, 114.0
27.0, 27.0

p4

p4

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c13 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m18*m11*0.1

nodelay

--

true

0

false

PMID: 1492121 The major events of early activation involve plasma membrane inositol phospholipid hydrolysis.

Go back
797.0, 1333.0
21.0, 21.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c134 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m64*m71*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
1243.0, 1107.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m70*m69*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
798.0, 1282.0
19.0, 19.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c141 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m64*m73*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
199.0, 1159.0
25.0, 25.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m72*m74*0.1

nodelay

--

true

0

false

PMID: 1492121, 2263644, 1378279 NF-kappaB activation is induced by a variety of substances, such as PMA, inflammatory cytokines (TNF-beta and IL-1), agents provoking oxidative stresses (H202).

Go back
448.0, 568.0
23.0, 23.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m75*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 2137553 Ets-I and Ets-2 are phosphorylated in T cells upon antigen stimulation and calcium ionophore stimulation mimics this reaction.

Go back
1025.0, 549.0
21.0, 21.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m77*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 2137553 Ets-I and Ets-2 are phosphorylated in T cells upon antigen stimulation and calcium ionophore stimulation mimics this reaction.

Go back
411.0, 567.0
25.0, 25.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m75*m27*0.1

nodelay

--

true

0

false

PMID: 1492121, 2137553 Ets-I and Ets-2 are phosphorylated in T cells upon antigen stimulation and calcium ionophore stimulation mimics this reaction.

Go back
990.0, 558.0
19.0, 19.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m77*m27*0.1

nodelay

--

true

0

false

PMID: 1492121, 2137553 Ets-I and Ets-2 are phosphorylated in T cells upon antigen stimulation and calcium ionophore stimulation mimics this reaction.

Go back
872.0, 192.0
23.0, 23.0

p5

p5

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1

m11*m19*0.1

nodelay

--

true

0

false

PMID: 1492121 The major events of early activation involve (1) plasma membrane inositol phospholipid hydrolysis, (2) increases in cytoplasmic calcium concentration.

Go back
1077.0, 533.0
21.0, 21.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c19 : 1
stoichiometry:c18 : 1

m22*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 2201921 Activation of p21ras following stimulation of the TCR suggests the involvement of the ras protooncogene in T cell activation.

Go back
661.0, 137.0
21.0, 21.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c21 : 1

m24*m11*0.1

nodelay

--

true

0

false

PMID: 1492121, 2785241 The involvement of one or more isozymes of protein kinase C in TCR-mediated signaling has been established by experiments using phorbol ester or constitutively active protein kinase C.

Go back
669.0, 101.0
21.0, 21.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c23 : 1
stoichiometry:c25 : 1

m26*m24*0.1

nodelay

--

true

0

false

The involvement of one or more isozymes of protein kinase C in TCR-mediated signaling has been established by experiments using phorbol ester or constitutively active protein kinase C.

Go back
763.0, 275.0
26.0, 26.0

p9

p9

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 1492121 A combination of phorbol ester (PMA) and calcium ionophore (A23187) is required for maximal activation of cytokine genes, suggesting a synergy between the processes mediated by Ca + and by protein kinase C. The production of IL-2 or GM-CSF shows such synergy between these two signals.

Go back
1199.98308259552, 238.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.89081263318, 77.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.30597955666127, 481.0

c100

c100

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
656.8194785650893, 426.0

c101

c101

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
477.90471387195737, 426.0

c102

c102

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
471.8016356253845, 409.0

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
648.0, 409.0

c104

c104

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
755.0, 1085.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.0, 1124.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1026.0, 1080.8884174207467

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.9225366984449, 481.0

c108

c108

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
895.0, 481.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
878.0, 128.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.4768282812466, 426.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
832.0, 426.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
650.0, 409.0

c112

c112

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
656.0, 409.0

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1200.0, 223.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 1143.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 1180.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 1180.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.0, 1306.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 1262.1818100362018

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 128.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 1324.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 1173.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.2896078772961, 1086.0016704761629

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0, 197.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 1275.1739650574964

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 1274.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1243.1372138883064

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 1257.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 1309.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 1252.615501413805

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.8774685960507, 145.4272795120979

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 1329.4437601569803

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.0, 1103.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1275.6115561484353, 1105.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.8, 1132.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.5872770144946, 1225.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 1293.4990262892416

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 1244.7765906747113

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 1293.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
150.0, 1169.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.7023071186542, 1153.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 215.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 1184.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 1265.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.3897804297073, 527.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.08784016584013, 591.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.7009359345054, 382.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1008.0, 515.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.9684350024884, 570.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.0335858293438, 402.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.1159660434202, 527.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.0, 592.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.942766353703, 213.97466921364406

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.8724307086002, 297.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
999.0, 515.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 577.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 297.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
850.0, 145.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1103.2809168618294, 500.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1095.0, 554.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1097.9929776408935, 408.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1262.0, 228.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.3531602401445, 123.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.4366232265812, 123.94900576226499

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.3061102823157, 155.25894960725702

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0, 112.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 116.94832658630703

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0, 112.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 288.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 281.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.4133125023502, 799.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0680290823638, 305.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1249.0, 238.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 803.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.0, 126.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.8248474318787, 807.6648611557189

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
399.1165361451483, 782.6544374799411

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.9951044972843, 844.2798286574049

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
443.58701050128076, 126.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.82082133068496, 790.3843309514476

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.07291691435927, 305.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.0, 815.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.8611781328564, 819.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 144.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.1607030803407, 305.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 126.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.0, 743.3037713130234

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
806.0, 814.3637577833765

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1022.0, 740.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1023.0, 801.1867236234419

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.0, 305.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 126.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.4247842258704, 901.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 197.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1063.0, 192.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.93422400624104, 885.9895535378373

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
383.65685424949237, 887.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0959451230902, 197.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 911.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 197.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 979.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 968.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
369.44201152930793, 197.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 984.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.9105674288418, 1075.1928633424443

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.3297095121402, 210.27413462652174

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 1084.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 197.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.2226515371626, 197.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.0, 910.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 893.3423690826311

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1044.0, 884.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.0, 297.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 297.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 951.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 1008.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.0, 379.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 1008.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 297.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 297.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.1659646153463, 1080.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.0, 1068.7144911482437

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1059.0, 1064.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 297.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 297.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.2479786425013, 602.0

c78

c78

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
937.0, 602.0

c79

c79

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1078.0, 436.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.129939714555, 602.0

c80

c80

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
936.0, 602.0

c81

c81

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
935.0, 602.0

c82

c82

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
797.1190233615725, 602.0

c83

c83

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
940.0, 602.0

c84

c84

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
937.0, 602.0

c85

c85

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
756.6317728773718, 602.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
816.9593378438225, 602.0

c87

c87

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
453.66149636992867, 599.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
441.56699763094997, 601.0

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1125.3148177390106, 392.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.3337655307279, 602.0

c90

c90

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
690.1544135194698, 602.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
691.0, 915.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.6784732279592, 481.0

c93

c93

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
780.0, 798.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.3031752223202, 481.0

c95

c95

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
650.0, 776.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.5197706588216, 481.0

c97

c97

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
399.9298232054611, 757.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.2163243858115, 764.4532104422901

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back