1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/14962188.csml convertedTime:2009.07.01.10:44

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1during B-cell development.
Authors Milne CD, Fleming HE, Zhang Y, Paige CJ.
Affiliation Princess Margaret Hospital, Toronto, ON, Canada. cmline@uhnres.utoronto.ca
Abstract Many of the stromal-derived signals and factors that regulate B lymphopoiesishave been identified. We review recent evidence from our laboratory that showsthat there are at least three phases during B-cell development when cells directtheir own maturation, independent of stromal cells. Following the expression ofthe preB-cell receptor (preBCR), cells acquire the ability to proliferate in lowlevels of interleukin-7 (IL-7), which acts as a self-selecting mechanism toexpand cells that have successfully expressed a preBCR in environments that arenon-permissive to preBCR- cells. Second, the preBCR is required for acontact-mediated event between B-cell progenitors. Disruption at this stageprevents the further maturation of progenitors to the lipopolysaccharide(LPS)-responsive stage. Finally, the transition from IL-7 receptor to matureantigen receptor-based signaling is enhanced by a novel member of the tachykininfamily, hemokinin-1. This series of maturation, survival, and differentiationsignals is generated by B-lineage cells as they progress through developmentalcheckpoints on the way to becoming functionally mature cells.
PMID 14962188
Model Abstract

Entity

G010392:CD19 G010760:bax G013157:RAG2 G043902:HK1 MO000000030:PI3K {activated} MO000000145:Jak MO000016830:IL-7 MO000016840:IL-7R MO000017843:Igalpha MO000017844:Igbeta MO000018418:tachykinin receptors MO000018420:NK2 MO000018421:NK3 MO000018926:heparin MO000019980:SLC MO000023541:hk1 MO000067392:RAG2 MO000089931:syndecan-4 MO000099908:NK-1 e1: e10: e11:Bax e12:VPREB e13:heparan {activated} e14:heparin {activated} e15:Ig e16:heparan sulphate e17:preBCR e18:lambda5 e19:lambda5: VpreB: Igalpha: Igbeta: preBCR e2: e20:IL-7{extracellular} e21:IL-7: IL-7R e22:preBCR{activated} e23:heparan e26:IL-7: IL-7Ralpha: lambdac e27:Jak {activated} e28:STAT e29:STAT [activated} e3: e30:PI3K e31:Ras {activated} e32:Ras e33:ERK e34:ERK [activated} e35:pERK e36:heparan sulphate: SLC: lambda5: VpreB: Igalpha: Igbeta: preBCR e37:galectin-1 e38:heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR: galectin-1 e39:NK-1 {activated} e4: e41:heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR e42:heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR e43:syndecan-1 e44:syndecan-4 e45:preprotachykinin e46:NK2 {activated} e47:NK3 {activated} e48:Ig e49:antigen e5:preBCR e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:syndecan-1 e60: e61: e62: e63:antigen: tachykinin receptors e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p4 p5 p6 p7 p8 p9
Model Detail
923.0, 974.0
36.0, 36.0

CD19

--

G010392

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93367

10

false

infinite

0

unit false false false
TRANSFACG010392

--

Go back
678.0, 941.0
38.0, 38.0

bax

--

G010760

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p6

p7

true true true true

csml-variable:Double

m93669

10

false

infinite

0

unit false false false
TRANSFACG010760

--

Go back
818.0, 857.0
37.0, 37.0

RAG2

--

G013157

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m95652

10

false

infinite

0

unit false false false
TRANSFACG013157

--

Go back
722.0, 857.0
38.0, 38.0

HK1

--

G043902

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3

p4

true true true true

csml-variable:Double

m114303

10

false

infinite

0

unit false false false
TRANSFACG043902

--

Go back
948.0, 411.0
34.0, 34.0

PI3K {activated}

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1097.0, 392.0
32.0, 32.0

Jak

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
1047.0, 858.0
36.0, 36.0

IL-7

--

MO000016830

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p11 p13 p14

true true true true

csml-variable:Double

m1767

10

false

infinite

0

unit false false false
InterProIPR001181
TRANSPATHMO000016830

--

Go back
1198.0, 786.0
36.0, 36.0

IL-7R

--

MO000016840

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1776

10

false

infinite

0

unit false false false
TRANSPATHMO000016840

--

Go back
472.0, 487.0
34.0, 34.0

Igalpha

--

MO000017843

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2595

10

false

infinite

0

unit false false false
TRANSPATHMO000017843

--

Go back
472.0, 423.0
33.0, 33.0

Igbeta

--

MO000017844

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2596

10

false

infinite

0

unit false false false
TRANSPATHMO000017844

--

Go back
925.0, 92.0
31.0, 31.0

tachykinin receptors

--

MO000018418

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m3056

10

false

infinite

0

unit false false false
TRANSPATHMO000018418

--

Go back
457.0, 104.0
32.0, 32.0

NK2

--

MO000018420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m3058

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018420

--

Go back
647.0, 102.0
35.0, 35.0

NK3

--

MO000018421

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m3059

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018421

--

Go back
1114.0, 829.0
37.0, 37.0

heparin

--

MO000018926

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m356124

10

false

infinite

0

unit false false false
TRANSPATHMO000018926

--

Go back
669.0, 1184.0
32.0, 32.0

SLC

--

MO000019980

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m4508

10

false

infinite

0

unit false false false
TRANSPATHMO000019980

--

Go back
581.0, 748.0
40.0, 40.0

hk1

--

MO000023541

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m7316

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000023541

--

Go back
558.0, 889.0
38.0, 38.0

RAG2

--

MO000067392

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7

true true true true

csml-variable:Double

m42245

10

false

infinite

0

unit false false false
TRANSPATHMO000067392

--

Go back
1076.0, 1075.0
42.0, 42.0

syndecan-4

--

MO000089931

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

--

true true true true

csml-variable:Double

m63496

10

false

infinite

0

unit false false false
TRANSPATHMO000089931

--

Go back
405.0, 204.0
32.0, 32.0

NK-1

--

MO000099908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m72948

10

false

infinite

0

unit false false false
TRANSPATHMO000099908

--

Go back
385.75, 75.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
394.0, 95.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
557.0, 1020.0
39.0, 39.0

Bax

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000048162

--

Go back
476.0, 551.0
34.0, 34.0

VPREB

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000065268

--

Go back
1005.0, 723.75
40.613805594687065, 25.045180116723685

heparan {activated}

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1090.0, 709.0
37.0, 37.0

heparin {activated}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000018926

--

Go back
890.5, 924.0
45.0, 24.0

Ig

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
319.0, 899.0
44.50798990748528, 25.221194280908318

heparan sulphate

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
764.0, 1124.0
39.0, 39.0

preBCR

--

e17

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSFACG010301

--

Go back
478.0, 608.75
30.0, 22.5

lambda5

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
395.25, 804.0
51.72389429253076, 72.17287575701963

lambda5: VpreB: Igalpha: Igbeta: preBCR

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
385.75, 75.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1290.0, 858.0
36.0, 36.0

IL-7{extracellular}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p9

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR001181
TRANSPATHMO000016830

--

Go back
1198.25, 685.0
36.15533874150406, 69.97807498355624

IL-7: IL-7R

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p2

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
404.0, 703.0
33.5, 33.5

preBCR{activated}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
977.0, 835.75
40.613805594687065, 25.045180116723685

heparan

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1191.25, 517.0
36.15533874150406, 69.97807498355624

IL-7: IL-7Ralpha: lambdac

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1033.0, 392.0
32.0, 32.0

Jak {activated}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
1101.0, 324.0
40.0, 40.0

STAT

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
957.0, 324.0
40.0, 40.0

STAT [activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
402.875188623529, 93.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
948.0, 459.0
34.0, 34.0

PI3K

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
953.0, 571.75
39.81686456027369, 24.553733145502118

Ras {activated}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19 p20

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
881.0, 507.75
39.81686456027369, 24.553733145502118

Ras

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19 p20

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
786.0, 701.0
38.0, 38.0

ERK

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
858.0, 761.0
38.0, 38.0

ERK [activated}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
694.0, 763.75
53.04, 39.78

pERK

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
489.25, 1166.0
48.16489264085154, 67.20682694072306

heparan sulphate: SLC: lambda5: VpreB: Igalpha: Igbeta: preBCR

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
631.75, 1131.0
26.30358220970014, 42.654457637351584

galectin-1

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
487.25, 1097.0
43.78518994310883, 61.095613874105325

heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR: galectin-1

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
405.0, 260.0
32.0, 32.0

NK-1 {activated}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000099908

--

Go back
434.5567875770579, 123.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
388.875, 973.5
55.62419710038538, 77.6151587447238

heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
476.875, 945.5
55.62419710038538, 77.6151587447238

heparan sulphate: lambda5: VpreB: Igalpha: Igbeta: preBCR

--

e42

cso30:c:Complex

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
862.5, 1032.0
45.0, 24.0

syndecan-1

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
862.5, 1080.0
45.0, 24.0

syndecan-4

--

e44

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
994.5, 166.125
45.0, 27.75

preprotachykinin

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
509.0, 84.0
32.0, 32.0

NK2 {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018420

--

Go back
703.0, 82.0
35.0, 35.0

NK3 {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000018421

--

Go back
1276.5, 920.125
41.0, 30.75

Ig

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
972.5, 30.375
40.746924428822496, 26.48550087873462

antigen

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
400.0, 647.0
33.5, 33.5

preBCR

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
610.0, 812.0
387.5132797247767, 351.4319687634384

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
651.8543207151529, 820.328426757972
226.59063283720656, 340.60757547503687

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
615.0513835345873, 816.6905704249739
377.4105126556021, 342.0508279134901

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
615.7730097538142, 817.4121966442008
375.9672602171485, 340.60757547503687

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
610.0, 812.0
387.5132797247767, 351.4319687634384

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
610.0, 812.0
387.5132797247767, 351.4319687634384

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
615.7730097538142, 817.4121966442008
375.9672602171485, 340.60757547503687

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
895.3740733668927, 956.3252438453542
24.20970052390993, 21.91614994796059

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
829.3743706449391, 1056.5207160604366
68.55449082654337, 62.05985485350252

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
610.0, 812.0
387.5132797247767, 351.4319687634384

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1076.0, 1023.0
42.0, 42.0

syndecan-1

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

--

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000089931

--

Go back
697.1737072606534, 967.3412645355417
12.271976177930153, 5.90872927085527

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
696.7639112392427, 949.7200356148741
42.00409219461495, 75.6073659503069

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
714.3851401599107, 998.8955581841789
6.5567363425740375, 6.556736342574039

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1050.625, 89.5
36.75, 45.0

antigen: tachykinin receptors

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
397.0, 81.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
400.0, 102.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
408.0, 123.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
734.0, 1017.0
30.0, 30.0

p1

p1

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

--

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14962188 The first phase occurs once cells have productively rearranged the m-heavy chain (HC) and express the preB-cell receptor (preBCR).

Go back
862.0, 977.0
30.0, 30.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

--

G010392

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14962188, 7831294, 7964471, 11602642 Not only do progenitor B cells require IL-7 for efficient in vitro differentiation (3) but also to reach one of the earliest identifiable stages of B-cell development based on the expression of CD19.

Go back
878.0, 861.0
30.0, 30.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c24 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14962188, 9022004, 7686307, 9495344 For example, IL-7 has been implicated in altering the expression of RAG proteins, targeting of the recombination machinery to specific Ig gene segments, and also by inducing signal transducers and activators of transcription-5 (STAT5)-dependent accessibility of the T-cell receptor (TCR) lambda locus.

Go back
326.0, 653.0
30.0, 30.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 14962188 The activation of both the preBCR and the IL-7R can induce survival, proliferation, and differentiation of cells during the proB to preB-cell transition.

Go back
1010.0, 777.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c32 : 1
stoichiometry:c29 : 1

m24*m1767*0.1

nodelay

--

true

0

false

PMID: 14962188, 8589262, 9864155 Heparin and heparan sulfate have also been shown to influence the activity of IL-7.

Go back
1094.0, 777.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c33 : 1
stoichiometry:c31 : 1

m356124*m1767*0.1

nodelay

--

true

0

false

PMID: 14962188, 8589262, 9864155 Heparin and heparan sulfate have also been shown to influence the activity of IL-7.

Go back
1281.0, 1017.0
30.0, 30.0

p15

p15

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c64 : 1

m93367*m18*0.1

nodelay

--

true

0

false

PMID: 14962188, 7831294, 7964471, 11602642 Not only do progenitor B cells require IL-7 for efficient in vitro differentiation (3) but also to reach one of the earliest identifiable stages of B-cell development based on the expression of CD19. PMID: 14962188 The first phase occurs once cells have productively rearranged the m-heavy chain (HC) and express the preB-cell receptor (preBCR).

Go back
1098.0, 453.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c41 : 1
stoichiometry:c37 : 1

m129*m27*0.1

nodelay

--

true

0

false

PMID: 14962188, 10379911 Signaling pathways known to be activated by the IL-7R include the Janus kinase (JAK)/STAT cascade, the phosphoinositide 3-kinase (PI3K), and Ras-GTPase pathways.

Go back
1038.0, 329.0
30.0, 30.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m29*m28*0.1

nodelay

--

true

0

false

PMID: 14962188, 10379911 Signaling pathways known to be activated by the IL-7R include the Janus kinase (JAK)/STAT cascade, the phosphoinositide 3-kinase (PI3K), and Ras-GTPase pathways.

Go back
1022.0, 461.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m27*m32*0.1

nodelay

--

true

0

false

PMID: 14962188, 10379911 Signaling pathways known to be activated by the IL-7R include the Janus kinase (JAK)/STAT cascade, the phosphoinositide 3-kinase (PI3K), and Ras-GTPase pathways.

Go back
1042.0, 569.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m27*m34*0.1

nodelay

--

true

0

false

PMID: 14962188, 10379911 Signaling pathways known to be activated by the IL-7R include the Janus kinase (JAK)/STAT cascade, the phosphoinositide 3-kinase (PI3K), and Ras-GTPase pathways.

Go back
1254.0, 605.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 14962188 Binding of IL-7 to the specific IL-7Ra chain leads to heterodimerization with the gammac chain.

Go back
886.0, 569.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m34*m23*0.1

nodelay

--

true

0

false

PMID: 14962188 Ras is also activated by the preBCR.

Go back
862.0, 705.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c57 : 1
stoichiometry:c52 : 1

m35*m27*m37*0.1

nodelay

--

true

0

false

PMID: 14962188, 11672535 ERK is specifically activated following preB-cell stimulation with IL-7, and this activation can occur concurrently with ERK phosphorylation mediated by the preBCR. PMID: 14962188 pERK derived from preBCR signals can also contribute to the amount of activated ERK.

Go back
706.0, 705.0
30.0, 30.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m35*m23*0.1

nodelay

--

true

0

false

PMID: 14962188, 11672535 ERK is specifically activated following preB-cell stimulation with IL-7, and this activation can occur concurrently with ERK phosphorylation mediated by the preBCR.

Go back
586.0, 1185.0
30.0, 30.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c63 : 1
stoichiometry:c60 : 1

m4508*m40*0.1

nodelay

--

true

0

false

PMID: 14962188, 12039909, 9233622, 8548286 The hypothesis that no ligand is required for preBCR function is supported by the finding that a variety of truncated preBCR constructs retain their function in the absence of most of the extracellular portion of the complex and/or the ability to bind SLCs.

Go back
574.0, 1089.0
30.0, 30.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c68 : 1
stoichiometry:c62 : 1

m39*m44*0.1

nodelay

--

true

0

false

PMID: 14962188, 12271131 In humans, galectin-1 has been identified as a binding partner for the preBCR.

Go back
466.0, 897.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c34 : 1
stoichiometry:c65 : 1

m20*m15*0.1

nodelay

--

true

0

false

PMID: 14962188 This interaction requires the unique tail of l5, which binds heparan sulfate as a ligand.

Go back
466.0, 1049.0
30.0, 30.0

p26

p26

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 14962188, 1722112 heparin treatment of preBCR+ 70Z/3 cells induces internalization of the receptor.

Go back
798.0, 1029.0
30.0, 30.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

--

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1

1.0*0.1

nodelay

--

true

0

false

PMID; 14962188, 8707854, 7812048, 10229831 Both B cells and stromal cells produce syndecan-1 and syndecan-4.

Go back
798.0, 1077.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

--

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1

1.0*0.1

nodelay

--

true

0

false

PMID; 14962188, 8707854, 7812048, 10229831 Both B cells and stromal cells produce syndecan-1 and syndecan-4.

Go back
1018.0, 1029.0
30.0, 30.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c71 : 1

m45*0.1

nodelay

--

true

0

false

PMID; 14962188, 8707854, 7812048, 10229831 Both B cells and stromal cells produce syndecan-1 and syndecan-4.

Go back
754.0, 917.0
30.0, 30.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

--

G043902

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14962188, 11062498 Hemokinin-1 (HK1) is produced by preB cells and acts in an autocrine or paracrine fashion at this critical checkpoint.

Go back
1006.0, 1081.0
30.0, 30.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c72 : 1

m46*0.1

nodelay

--

true

0

false

PMID; 14962188, 8707854, 7812048, 10229831 Both B cells and stromal cells produce syndecan-1 and syndecan-4.

Go back
926.0, 165.0
30.0, 30.0

p31

p31

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 14962188 Similar to other small bioactive peptides, tachykinins are generated through proteolytic cleavage of larger precursors called preprotachykinins (PPTs).

Go back
466.0, 229.0
30.0, 30.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c83 : 1
stoichiometry:c78 : 1

m72948*m7316*0.1

nodelay

--

true

0

false

PMID: 14962188 Recent studies by several groups have shown that HK1, when applied at different concentrations, leads to the activation of all three known receptors.

Go back
510.0, 161.0
30.0, 30.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c84 : 1
stoichiometry:c80 : 1

m3058*m7316*0.1

nodelay

--

true

0

false

PMID: 14962188 Recent studies by several groups have shown that HK1, when applied at different concentrations, leads to the activation of all three known receptors.

Go back
706.0, 177.0
30.0, 30.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c85 : 1
stoichiometry:c82 : 1

m3059*m7316*0.1

nodelay

--

true

0

false

PMID: 14962188 Recent studies by several groups have shown that HK1, when applied at different concentrations, leads to the activation of all three known receptors.

Go back
818.0, 921.0
30.0, 30.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c86 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 14962188, 2445815, 1706387 Production of Igs by B lymphocytes, for example, is enhanced by substance P following LPS or antigen stimulation.

Go back
1082.0, 921.0
30.0, 30.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c92 : 1
stoichiometry:c87 : 1

m16*m65*0.1

nodelay

--

true

0

false

PMID: 14962188, 2445815, 1706387 Production of Igs by B lymphocytes, for example, is enhanced by substance P following LPS or antigen stimulation.

Go back
990.0, 81.0
30.0, 30.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m3056*m64*0.1

nodelay

--

true

0

false

PMID: 14962188, 2445815, 1706387 Production of Igs by B lymphocytes, for example, is enhanced by substance P following LPS or antigen stimulation.

Go back
642.0, 801.0
30.0, 30.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m114303*0.1

nodelay

--

true

0

false

PMID: 14962188, 11062498 Hemokinin-1 (HK1) is produced by preB cells and acts in an autocrine or paracrine fashion at this critical checkpoint.

Go back
578.0, 605.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c7 : 1
stoichiometry:c12 : 1

m2596*m2595*m13*m19*m23*0.1

nodelay

--

true

0

false

PMID: 14962188, 7688784 The preBCR complex includes surrogate lightchain (SLC) proteins l5 and VpreB and the signaling components Igalpha and Igbeta.

Go back
678.0, 893.0
30.0, 30.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c13 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 14962188, 9973461 For example, recombination-activating gene-2 (RAG2)-deficient proB cells exhibit higher levels of Bax, a pro-apoptotic mediator, and an increased Bax/Bcl2 ratio, consistent with elevated susceptibility to apoptosis.

Go back
562.0, 949.0
30.0, 30.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c17 : 1
stoichiometry:c15 : 1

m93669*0.1

nodelay

--

true

0

false

PMID: 14962188, 9973461 For example, recombination-activating gene-2 (RAG2)-deficient proB cells exhibit higher levels of Bax, a pro-apoptotic mediator, and an increased Bax/Bcl2 ratio, consistent with elevated susceptibility to apoptosis.

Go back
1201.0, 861.0
30.0, 30.0

p8

p8

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m1767*0.1

nodelay

--

true

0

false

PMID: 14962188, 1372556, 7545464 IL-7 is a 25-kDa member of the hematopoietin family secreted by reticular stromal cells in the bone marrow, thymic cortical epithelial cells, as well as by other cell types.

Go back
1293.0, 789.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m1776*m21*0.1

nodelay

--

true

0

false

PMID: 14962188 In the absence of a signal mediated by IL-7 binding to its receptor, Band T-cell differentiation is severely impaired.

Go back
754.0, 1047.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 577.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 620.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.9166036209292, 635.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 923.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.9951369419031, 961.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 979.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 908.0

c16

c16

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
577.0, 927.0

c17

c17

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1083.0, 876.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1231.0, 876.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1234.0, 642.0392431812576

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1234.0, 804.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1308.0, 827.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1239.9513662243562, 742.3461425405233

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 992.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.0, 876.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 876.0

c25

c25

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
363.9917483216824, 665.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 678.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.0, 814.1057411452476

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 757.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.3721553979108, 578.9278956114879

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1118.3104235544095, 814.2829318197008

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1109.0, 754.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.406376290639, 814.238549617608

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1074.0, 814.0703033307765

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
364.0, 912.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.0, 994.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1113.0, 424.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.830784576752, 428.4774036933124

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.0, 344.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 344.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.5777087639997, 902.1554175279994

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.0, 366.9853479730495

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1134.0265355456881, 486.26126119068016

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1059.3256253004695, 486.21484275776

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.0, 476.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.6307893926052, 443.4757828400085

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.8290956224794, 556.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.0, 528.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 584.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
901.0, 532.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 584.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.4922747316119, 831.6744378067606

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.0, 590.1818807901979

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
824.0, 720.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 735.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.1410303056946, 561.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 720.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 735.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 720.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.0, 729.0265551842863

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 871.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 1200.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0740528189224, 791.2063309876478

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 1200.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0740528189224, 1122.2063309876478

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.6576914183888, 1108.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 1145.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.0, 1036.7163994524592

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.30428362337494, 927.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 1035.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 1030.6462320697756

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 1023.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1044.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
438.0, 633.0063402982682

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1092.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 1044.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 1096.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 1044.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.0, 1093.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
964.0, 180.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 131.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 226.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.1057411452476, 252.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 136.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.0, 456.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.0, 124.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 137.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 125.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.8930311412464, 244.02199956321627

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
288.50289092568227, 176.0169377533084

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
305.1717934033987, 192.00890084069147

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
848.0, 936.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 936.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.0, 936.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 100.39028267127239

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 521.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 57.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 100.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.0, 122.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
855.8169907678446, 112.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back