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PMID: 15049289
In the prototypical
pathway, NF-KappaB is retained in the cytoplasm by IKappaB
inhibitor proteins.
indirect
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
indirect
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
indirect
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
indirect
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
indirect
indirect
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289, 12910267
Bcl10
is required for full LPS activation of NF-kB in MZ B cells
but not in follicular B cells.
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289, 12909454
Carma1 is lipid raft-associated, co-localizes with
the T-cell receptor (TCR) in T cells and is required for
TCR-activation of NF-KappaB
indirect
PMID: 15049289, 12909454
Carma1 is lipid raft-associated, co-localizes with
the T-cell receptor (TCR) in T cells and is required for
TCR-activation of NF-KappaB.
PMID: 15049289, 10880523
These results suggest that Bcl10 might have a specific
role downstream of LPS receptor signaling, which on mature B cells includes Toll-like receptor 4 (TLR4) and
RP105 (CD180)
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
PMID: 15049289
BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
indirect
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
indirect
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
indirect
indirect
PMID: 15049289
BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 12154360, 12867038
Bcl10 is recruited to the
membrane by dimerization with the CARD domain of the hematopoietic-specific membrane-associated guanylate
kinase (MAGUK) protein Carma1 (CARD11 or Bimp3)
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
indirect
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
indirect
indirect
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
indirect
indirect
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
indirect
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
indirect
indirect
indirect
PMID: 15049289
LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1
indirect
indirect
indirect
PMID: 15049289
LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
indirect
indirect
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289, 12910267
Bcl10
is required for full LPS activation of NF-kB in MZ B cells
but not in follicular B cells.
indirect
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.