Original Literature | Model OverView |
---|---|
Publication
Title
New roles for Bcl10 in B-cell development and LPS response.
Affiliation
Immune Receptor Signaling Group, Department of Physiological Chemistry,University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.klaus.fischer@medizin.uni-ulm.de
Abstract
PMID
15049289
|
Entity
NF-kappaB
--
MO000000058
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m5
10
infinite
0
TRANSPATH | MO000000058 |
--
IKK{active}
--
MO000000248
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m207
10
infinite
0
TRANSPATH | MO000000248 |
--
Bcl-10
--
MO000044192
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21910
10
infinite
0
InterPro | IPR001315 |
TRANSPATH | MO000044192 |
--
CARD11{active}
--
MO000044197
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m21915
10
infinite
0
InterPro | IPR001315 |
TRANSPATH | MO000044197 |
--
MALT1
--
MO000063418
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m38297
10
infinite
0
TRANSPATH | MO000063418 |
--
--
e1
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane
--
--
--
csml-variable:Double
m1
0
infinite
0
--
--
e10
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytosol
--
--
--
csml-variable:Double
m10
0
infinite
0
--
NF-KappaB:IKappaB{p}{ub}
--
e11
cso30:c:Protein
cso30:i:CC_Cytosol
--
csml-variable:Double
m12
0
infinite
0
--
NF-kappaB{active}
--
e12
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m13
10
infinite
0
TRANSPATH | MO000000058 |
--
proteosome remnant
--
e13
cso30:c:EntityBiological
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m14
0
infinite
0
--
mRNA
--
e15
cso30:c:mRNA
cso30:i:CC_Nucleoplasm
--
--
csml-variable:Double
m16
0
infinite
0
--
mitogens
--
e16
cso30:c:Protein
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m17
0
infinite
0
--
antigen receptor
--
e17
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m18
0
infinite
0
--
mitogen:receptor
--
e18
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m19
0
infinite
0
--
cytokines
--
e19
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m20
0
infinite
0
--
--
e2
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m2
0
infinite
0
--
receptor
--
e20
cso30:c:Protein
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
csml-variable:Double
m21
0
infinite
0
--
cytokine:receptor
--
e21
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m22
0
infinite
0
--
LPS:TLR4
--
e22
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m23
0
infinite
0
--
CARD11:Bcl-10
--
e23
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m24
0
infinite
0
--
CARD11:TCR
--
e24
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m25
0
infinite
0
--
LPS:RP105
--
e25
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m26
0
infinite
0
--
B-cell antigen
--
e26
cso30:c:Protein
cso30:i:CC_Extracellular
--
--
csml-variable:Double
m27
0
infinite
0
--
antigen:BCR
--
e27
cso30:c:Complex
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
csml-variable:Double
m28
0
infinite
0
--
IKK
--
e28
cso30:c:Protein
cso30:i:CC_CellComponent
--
csml-variable:Double
m29
10
infinite
0
TRANSPATH | MO000000248 |
--
calcium
--
e29
cso30:c:SmallMolecule
cso30:i:CC_Cytosol
--
--
csml-variable:Double
m30
0
infinite
0
--
--
e3
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_
--
--
--
csml-variable:Double
m3
0
infinite
0
--
Bcl-10:MALT1
--
e35
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m37
0
infinite
0
--
--
e4
cso30:c:EntityBiologicalCompartment
cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_
--
--
--
csml-variable:Double
m4
0
infinite
0
--
NF-KappaB:IKappaB
--
e5
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m6
0
infinite
0
--
--
e50
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelopeLumen
--
--
--
csml-variable:Double
m50
0
infinite
0
--
--
e51
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearPore
--
--
--
csml-variable:Double
m51
0
infinite
0
--
--
e52
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearInnerMembrane
--
--
--
csml-variable:Double
m52
0
infinite
0
--
--
e53
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearLumen
--
--
--
csml-variable:Double
m53
0
infinite
0
--
--
e54
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearOuterMembrane
--
--
--
csml-variable:Double
m54
0
infinite
0
--
--
e55
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleus
--
--
--
csml-variable:Double
m55
0
infinite
0
--
--
e56
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleoplasm
--
--
--
csml-variable:Double
m56
0
infinite
0
--
--
e57
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearBody
--
--
--
csml-variable:Double
m57
0
infinite
0
--
--
e58
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Nucleolus
--
--
--
csml-variable:Double
m58
0
infinite
0
--
--
e59
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearEnvelope
--
--
--
csml-variable:Double
m59
0
infinite
0
--
NF-KappB:IKappaB{p}
--
e6
cso30:c:Complex
cso30:i:CC_Cytosol
--
csml-variable:Double
m11
0
infinite
0
--
--
e60
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Chromatin
--
--
--
csml-variable:Double
m60
0
infinite
0
--
--
e61
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearChromosome
--
--
--
csml-variable:Double
m61
0
infinite
0
--
--
e62
cso30:c:EntityBiologicalCompartment
cso30:i:CC_NuclearCentromere
--
--
--
csml-variable:Double
m62
0
infinite
0
--
--
e7
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell
--
--
--
csml-variable:Double
m7
0
infinite
0
--
--
e8
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cell_WithoutCellWall_
--
--
--
csml-variable:Double
m8
0
infinite
0
--
--
e9
cso30:c:EntityBiologicalCompartment
cso30:i:CC_Cytoplasm
--
--
--
csml-variable:Double
m9
0
infinite
0
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1
m186*m5*0.1
nodelay
--
0
PMID: 15049289 In the prototypical pathway, NF-KappaB is retained in the cytoplasm by IKappaB inhibitor proteins.
p8
p10
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
m22*m5*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).
p8
p11
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c67 : 1
stoichiometry:c33 : 1
m23*m5*m21910*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS). PMID: 15049289, 12910267 Bcl10 is required for full LPS activation of NF-kB in MZ B cells but not in follicular B cells.
p12
p12
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
m155666*m3961*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).
p13
p13
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
m21915*m21910*0.1
nodelay
--
0
PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 12154360, 12867038 Bcl10 is recruited to the membrane by dimerization with the CARD domain of the hematopoietic-specific membrane-associated guanylate kinase (MAGUK) protein Carma1 (CARD11 or Bimp3)
p14
p14
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
m21915*m2534*0.1
nodelay
--
0
PMID: 15049289, 12909454 Carma1 is lipid raft-associated, co-localizes with the T-cell receptor (TCR) in T cells and is required for TCR-activation of NF-KappaB
p15
p15
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1
m25*m5*0.1
nodelay
--
0
PMID: 15049289, 12909454 Carma1 is lipid raft-associated, co-localizes with the T-cell receptor (TCR) in T cells and is required for TCR-activation of NF-KappaB.
p16
p16
cso30:i:ME_Binding
cso30:i:CC_Extracellular
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1
m155666*m1632*0.1
nodelay
--
0
PMID: 15049289, 10880523 These results suggest that Bcl10 might have a specific role downstream of LPS receptor signaling, which on mature B cells includes Toll-like receptor 4 (TLR4) and RP105 (CD180)
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
m27*m2450*0.1
nodelay
--
0
PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB. PMID: 15049289 BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
m28*0.1
nodelay
--
0
PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
p18
p19
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
m28*m69*0.1
nodelay
--
0
PMID: 15049289 Stimulation of the BCR activates calcium and mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
m6*m207*0.1
nodelay
--
0
PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations
p20
p20
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1
m28*m32*m2244*0.1
nodelay
--
0
PMID: 15049289 BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
p21
p21
cso30:i:ME_Binding
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c59 : 1
stoichiometry:c96 : 1
m38297*m21910*0.1
nodelay
--
0
PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations
p22
p22
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c97 : 1
stoichiometry:c63 : 1
m29*m37*0.1
nodelay
--
0
PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations
p25
p25
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
m21910*m23*m29*0.1
nodelay
--
0
PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
p25
p26
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
m26*m21910*m29*0.1
nodelay
--
0
PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
p27
p27
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
m21915*m35*0.1
nodelay
--
0
PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation.
p28
p28
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1
m23*m38297*m21915*m29*0.1
nodelay
--
0
PMID: 15049289 LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1
p28
p29
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
m38297*m21915*m26*m29*0.1
nodelay
--
0
PMID: 15049289 LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
m11*0.1
nodelay
--
0
PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations
p8
p30
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1
m26*m5*m21910*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS). PMID: 15049289, 12910267 Bcl10 is required for full LPS activation of NF-kB in MZ B cells but not in follicular B cells.
p31
p31
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c61 : 1
stoichiometry:c98 : 1
m24*m29*0.1
nodelay
--
0
PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
m12*0.1
nodelay
--
0
PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells. PMID: 15049289 Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun N-terminal kinase (JNK) and proliferation. PMID: 15049289, 10339464, 11090634, 11262391 Bcl10 binds to and cooperatively activates NF-kB with MALT1 (paracaspase), a protein that was also identified in MALT chromosomal translocations
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
m13*0.1
nodelay
--
0
PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription. PMID: 15049289 Bcl10 is necessary for LPS induction of NF-kB and proliferation in MZ B cells but the requirement for Carma1 and MALT1 has not been tested. PMID: 15049289 Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
m15*0.1
nodelay
--
0
PMID: 15049289 Release of NF-kB is triggered by phosphorylation of IkB by the IkB kinase (IKK) kinase complex, leading to ubiquitin-mediated degradation of IkB and entry of NF-kB into the nucleus, where it can activate transcription.
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1
m17*m18*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).
p8
p8
cso30:i:ME_UnknownActivation
cso30:i:CC_Cytosol
--
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
m19*m5*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).
--
and
mass
coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
m20*m21*0.1
nodelay
--
0
PMID: 15049289 A wide variety of stimuli activate NF-kB, including mitogens for antigen receptors, proinflammatory cytokines and the bacterial product lipopolysaccharide (LPS).
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:InputProcess
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--
cso30:c:InputAssociation
threshold
--
0
1,
--
cso30:c:OutputProcess
threshold
--
0
1,
--