_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e4
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e56
_enti_e51
_enti_e52
_enti_e54
_enti_e50
_enti_e58
_enti_e57
_enti_e61
_enti_e62
_enti_e60
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 15049289
In the prototypical
pathway, NF-KappaB is retained in the cytoplasm by IKappaB
inhibitor proteins.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
c4 cso30:c:InputProcess connector
c5 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
c11 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
c12 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 15049289
Release of NF-kB is triggered by
phosphorylation of IkB by the IkB kinase (IKK) kinase
complex, leading to ubiquitin-mediated degradation of IkB
and entry of NF-kB into the nucleus, where it can activate
transcription.
c14 cso30:c:InputAssociation connector
c15 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
c19 cso30:c:InputAssociation connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p8_propro_p10
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
c25 cso30:c:InputAssociation connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p8_propro_p11
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289, 12910267
Bcl10
is required for full LPS activation of NF-kB in MZ B cells
but not in follicular B cells.
c31 cso30:c:InputAssociation connector
c32 cso30:c:InputProcess connector
c67 cso30:c:InputAssociation connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15049289, 12909454
Carma1 is lipid raft-associated, co-localizes with
the T-cell receptor (TCR) in T cells and is required for
TCR-activation of NF-KappaB
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15049289, 12909454
Carma1 is lipid raft-associated, co-localizes with
the T-cell receptor (TCR) in T cells and is required for
TCR-activation of NF-KappaB.
c40 cso30:c:InputAssociation connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 15049289, 10880523
These results suggest that Bcl10 might have a specific
role downstream of LPS receptor signaling, which on mature B cells includes Toll-like receptor 4 (TLR4) and
RP105 (CD180)
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
PMID: 15049289
BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
c46 cso30:c:InputProcess connector
c47 cso30:c:InputProcess connector
c48 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
c49 cso30:c:InputAssociation connector
c50 cso30:c:OutputProcess connector
p18_propro_p19
PMID: 15049289
Stimulation of the BCR activates calcium and
mitogen-activated protein kinase (MAPK) signaling as well as Carma1, Bcl10 and mucosa-associated lymphoma tissue 1 (MALT1) upstream of IkB kinase (IKK) and NF-KappaB.
c52 cso30:c:InputAssociation connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 15049289
BCR activation of Carma1 might be mediated by protein kinase Cb (PKCb
c55 cso30:c:InputAssociation connector
c56 cso30:c:InputProcess connector
c58 cso30:c:InputAssociation connector
c57 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 12154360, 12867038
Bcl10 is recruited to the
membrane by dimerization with the CARD domain of the hematopoietic-specific membrane-associated guanylate
kinase (MAGUK) protein Carma1 (CARD11 or Bimp3)
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
c60 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
PMID: 15049289, 10339464, 11090634, 11262391
Bcl10 binds to and
cooperatively activates NF-kB with MALT1 (paracaspase),
a protein that was also identified in MALT chromosomal
translocations
c62 cso30:c:InputProcess connector
c97 cso30:c:InputAssociation connector
c63 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
c71 cso30:c:InputAssociation connector
c72 cso30:c:InputAssociation connector
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p25_propro_p26
PMID: 15049289
Bcl10 is necessary for LPS induction of NF-kB and proliferation in
MZ B cells but the requirement for Carma1 and MALT1 has not been tested.
c75 cso30:c:InputAssociation connector
c76 cso30:c:InputAssociation connector
c77 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 15049289
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
c79 cso30:c:InputAssociation connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 15049289
LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1
c82 cso30:c:InputAssociation connector
c83 cso30:c:InputAssociation connector
c84 cso30:c:InputAssociation connector
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
p28_propro_p29
PMID: 15049289
LPS signaling in follicular B cells does not require Bcl10 but might depend on Carma1 and MALT1
Carma1 is required for signaling downstream of antigen receptors, for example, in BCR activation of NF-kB, Jun
N-terminal kinase (JNK) and proliferation.
c87 cso30:c:InputAssociation connector
c88 cso30:c:InputAssociation connector
c89 cso30:c:InputAssociation connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p8_propro_p30
PMID: 15049289
A wide variety of stimuli activate NF-kB,
including mitogens for antigen receptors, proinflammatory
cytokines and the bacterial product lipopolysaccharide
(LPS).
PMID: 15049289, 12910267
Bcl10
is required for full LPS activation of NF-kB in MZ B cells
but not in follicular B cells.
c92 cso30:c:InputAssociation connector
c93 cso30:c:InputProcess connector
c95 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 15049289
Carma1 associates with Bcl10, as does MALT1. It is unclear to what extent MALT1 contributes
to BCR signaling. Together, these signaling pathways lead to activation of NF-kB and development of mature B-cell lineages, including B-1 and marginal zone (MZ) B cells.
c51 cso30:c:InputAssociation connector
c61 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
NF-kappaB_enti_MO000000058
NF-kappaB
IkappaB_enti_MO000000215
IkappaB
NF-KappaB:IKappaB_enti_e5
NF-KappaB:IKappaB
IKK{active}_enti_MO000000248
IKK{active}
NF-KappB:IKappaB{p}_enti_e6
NF-KappB:IKappaB{p}
NF-KappaB:IKappaB{p}{ub}_enti_e11
NF-KappaB:IKappaB{p}{ub}
NF-kappaB{active}_enti_e12
NF-kappaB{active}
proteosome remnant_enti_e13
NF-kappaB{active}_enti_e14
NF-kappaB{active}
mRNA_enti_e15
mRNA
mitogens_enti_e16
mitogens
antigen receptor_enti_e17
antigen receptor
mitogen:receptor_enti_e18
mitogen:receptor
cytokines_enti_e19
cytokines
receptor_enti_e20
receptor
cytokine:receptor_enti_e21
cytokine:receptor
LPS_enti_MO000016882
LPS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e22
LPS:TLR4
Bcl-10_enti_MO000044192
Bcl-10
CARD11{active}_enti_MO000044197
CARD11{active}
CARD11:Bcl-10_enti_e23
CARD11:Bcl-10
TCR_enti_MO000017777
TCR
CARD11:TCR_enti_e24
CARD11:TCR
BCR_enti_MO000017690
BCR
RP105_enti_MO000016653
RP105
LPS:RP105_enti_e25
LPS:RP105
B-cell antigen_enti_e26
B-cell antigen
antigen:BCR_enti_e27
antigen:BCR
calcium_enti_e29
calcium
MAPKs_enti_MO000000077
MAPKs
MAPKs{active}_enti_e30
MAPKs{active}
CARD11_enti_e31
CARD11
PKCbeta_enti_MO000017414
PKCbeta
MALT1_enti_MO000063418
MALT1
IKK_enti_e28
IKK
JNK_enti_MO000000023
JNK
JNK{active}_enti_e34
JNK{active}
Bcl-10:MALT1_enti_e35
Bcl-10:MALT1