_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e55
_enti_e53
_enti_e59
_enti_e56
_enti_e51
_enti_e50
_enti_e54
_enti_e52
_enti_e58
_enti_e57
_enti_e61
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 15075353, 12086290, 11177775
COX-2 is an enzyme that converts arachidonic acid into proinflammatory prostaglandins.
c2 cso30:c:InputAssociation connector
c3 cso30:c:InputAssociation connector
c1 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 15075353, 12010565, 11817610, 11040455, 10517187
MMP-13 is a TNF-{alpha}-induced collagenase that has been implicated in proinflammatory, angiogenic, and destructive processes within the joint of patients with rheumatoid arthritis.
PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238
pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.
c5 cso30:c:InputAssociation connector
c55 cso30:c:InputInhibitor connector
c4 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 15075353, 10330172, 10751406, 11279239, 9703499
TTP is a zinc-finger protein that promotes the degradation of TNF-{alpha} transcripts.
c6 cso30:c:InputProcess connector
c8 cso30:c:InputAssociation connector
c7 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15075353, 9703499
In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.
c13 cso30:c:InputAssociation connector
c9 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 15075353, 9703499
In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 15075353, 9703499
In macrophages, its induction by lipopolysaccharide (LPS) appears to prevent the pathological overexpression of this proinflammatory cytokine.
c14 cso30:c:InputAssociation connector
c16 cso30:c:InputAssociation connector
c15 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 15075353, 10921895, 11762949
LPS-activated macrophages derived from wild-type and TIA-1/ mice express similar amounts of TNF-{alpha} transcripts, macrophages lacking TIA-1 produce significantly more TNF-{alpha} protein than wild-type controls.
c18 cso30:c:InputAssociation connector
c19 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 15075353, 10921895, 11762949
LPS-activated macrophages derived from wild-type and TIA-1/ mice express similar amounts of TNF-{alpha} transcripts, macrophages lacking TIA-1 produce significantly more TNF-{alpha} protein than wild-type controls.
PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238
pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.
c21 cso30:c:InputAssociation connector
c56 cso30:c:InputInhibitor connector
c20 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 15075353, 10557102, 10655230, 10882126, 11106749
Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 15075353, 10557102, 10655230, 10882126, 11106749
Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 15075353, 10557102, 10655230, 10882126, 11106749
Stress-induced translational arrest is characterized by the activation of one or more members of a family of serine/threonine kinases [e.g., double-stranded RNA-dependent protein kinase R (PKR), PKR-like endoplasmic reticulum kinase (PERK), GCN2.
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 15075353, 11909525
These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis
c28 cso30:c:InputProcess connector
c30 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 15075353, 11909525
These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis
c31 cso30:c:InputProcess connector
c33 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15075353, 11909525
These kinases phosphorylate eukaryotic initiation factor 2{alpha} (eIF2{alpha}), a component of the ternary complex that loads tRNAiMet onto the small ribosomal subunit to initiate protein synthesis
c34 cso30:c:InputProcess connector
c36 cso30:c:InputAssociation connector
c35 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15075353, 11438658
Phosphorylation of eIF2{alpha} inhibits protein translation by reducing the availability of an active ternary complex.
c37 cso30:c:InputInhibitor connector
p16_propro_p16
PMID: 15075353, 11546803
In extracts of 293 cells, calf intestinal alkaline phosphatase-induced dephosphorylation of recombinant TTP increases its affinity for AREs.
c38 cso30:c:InputProcess connector
c40 cso30:c:InputAssociation connector
c39 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 15075353, 11546803, 11533235
One of the candidate substrates for p38MAPK is TTP.
c41 cso30:c:InputProcess connector
c43 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 15075353
We found that MK2-induced phosphorylation of TTP results in the assembly of 14-3-3:TTP complexes, which are actively excluded from SGs.
c44 cso30:c:InputProcess connector
c46 cso30:c:InputAssociation connector
c45 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 15075353
We identified serine residues 52 and 178 as sites that are phosphorylated following p38MAPK/MK2 activation to create 14-3-3-binding sites.
c47 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 15075353, 12010565, 11817610, 11040455, 10517187
MMP-13 is a TNF-{alpha}-induced collagenase that has been implicated in proinflammatory, angiogenic, and destructive processes within the joint of patients with rheumatoid arthritis.
c50 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 15075353, 12767518, 12060661, 14516792, 12937622, 12852754, 12874238
pharmacological inhibitors of p38MAPK prevent the expression of TNF-{alpha}, COX-2, MMP-13, and other proinflammatory proteins.
c54 cso30:c:InputInhibitor connector
c53 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 15075353
TIA-1 interacts with specific components of the initiation complex that are assembled at the 5'-end of the transcript.
c57 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
arachidonic acid_enti_MO000000310
arachidonic acid
prostaglandins_enti_MO000021832
prostaglandins
COX-2_enti_MO000017266
COX-2
MMP13_enti_e5
MMP13
TNF-alpha_enti_MO000000289
TNF-alpha
TNF-alpha_enti_G010329
TNF-alpha
NTPs_enti_e6
NTPs
NTPs
TTP_enti_e11
TTP
TTP_enti_e12
TTP
LPS_enti_MO000016882
LPS
TLRs_enti_e13
TLRs
LPS:TLRs_enti_e14
LPS:TLRs
PKR_enti_MO000008179
PKR
PKR{active}_enti_e15
PKR{active}
PERK_enti_e16
PERK
PERK_enti_e17
PERK
GCN2_enti_e18
GCN2
GCN2{active}_enti_e19
GCN2{active}
eIF2alpha_enti_e20
eIF2alpha
eIF2alpha{p}_enti_e21
eIF2alpha{p}
TTP_enti_e22
TTP
TTP{p}_enti_e23
TTP{p}
alkaline phosphatase_enti_e24
alkaline phosphatase
p38_enti_MO000000022
p38
MK2_enti_e25
MK2
14-3-3_enti_MO000000074
14-3-3
TTP{p}:14-3-3_enti_e26
TTP{p}:14-3-3
TNF-alpha:TNFR_enti_e27
TNF-alpha:TNFR
TNFR_enti_e28
TNFR
COX2_enti_G029941
COX2
p38 inhibitor_enti_e29
p38 inhibitor
intiation complex_enti_e30
intiation complex
TIA1_enti_MO000069272
TIA1
mRNA_enti_e31
mRNA
initiation complex:TIA1:mRNA_enti_e32
initiation complex:TIA1:mRNA