_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e53
_enti_e59
_enti_e54
_enti_e50
_enti_e51
_enti_e56
_enti_e52
_enti_e61
_enti_e57
_enti_e58
_enti_e60
_enti_e62
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
p1_propro_p1
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c16 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 15075354, 12072369, 7500012, 12719478, 12719479
As mentioned, several non-TLR receptor chains cooperate with TLRs for the recognition of PAMPs; examples are CD14 and CD11b/CD18 for recognition of LPS by TLR4 [17 ], CD14 for recognition of lipoteichoic acid by TLR4 [18 ], and dectin-1 for recognition of zymosan and Candida albicans by TLR2 [19 , 20 ].
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c25 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c36 cso30:c:InputProcess connector
c37 cso30:c:InputProcess connector
c38 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15075354, 12527213
The specificity of TLR recognition for several important PAMPs has been identified, including recognition of peptidoglycan (PGN), bacterial lipoproteins, and zymosan by TLR2; double-stranded RNA by TLR3; lipopolysaccharide (LPS) and heat-shock proteins (HSPs) by TLR4; flagellin by TLR5; and CpG motifs of bacterial DNA by TLR9 [5 ].
c39 cso30:c:InputProcess connector
c40 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15075354
The TLRPAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 15075354
The TLRPAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).
c46 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 15075354
The TLRPAMP interaction results in the recruitment of specific adaptor molecules such as MyD88 and Mal, which then bind the IL-1R-associated kinase (IRAK).
c49 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 15075354, 11044373
The signal is thereafter transmitted through a chain of signaling molecules, which is apparently common to all TLRs, involving the tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) and mitogen-activated protein kinases.
c52 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 15075354, 11044373
The signal is thereafter transmitted through a chain of signaling molecules, which is apparently common to all TLRs, involving the tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) and mitogen-activated protein kinases.
c55 cso30:c:InputAssociation connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 15075354
Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.
c56 cso30:c:InputProcess connector
c58 cso30:c:InputAssociation connector
c57 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 15075354
Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.
c61 cso30:c:InputAssociation connector
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 15075354
Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.
c66 cso30:c:InputAssociation connector
c64 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 15075354
Thereafter, activation of nuclear factor NF-kappaB and activated protein-1 (AP-1) leads to transcription of genes involved in the activation of the innate host defense, notably proinflammatory cytokines.
c67 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 15075354, 14556004
Moreover, a recent study described TRAM as an adaptor molecule specifically recruited to TLR4.
PMID: 15075354
Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.
c68 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c69 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 15075354, 12855817, 12872135
Ligation of TLR4 or TLR3 recruits an additional adaptor molecule called TIR domain-containing, adapter-inducing interferon- (IFN-beta; TRIF).
c70 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c72 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 15075354, 12855817, 12872135
Ligation of TLR4 or TLR3 recruits an additional adaptor molecule called TIR domain-containing, adapter-inducing interferon- (IFN-beta; TRIF).
PMID: 15075354
Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.
c73 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
PMID: 15075354
Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.
c77 cso30:c:InputAssociation connector
c79 cso30:c:InputAssociation connector
c81 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
c78 cso30:c:InputAssociation connector
c80 cso30:c:InputAssociation connector
c82 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
c90 cso30:c:InputProcess connector
c86 cso30:c:InputAssociation connector
p30_propro_p30
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
PMID: 15075354
Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.
c84 cso30:c:InputAssociation connector
c89 cso30:c:InputProcess connector
p31_propro_p31
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
c85 cso30:c:InputAssociation connector
c87 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 15075354
In addition to potentiating the secretion of the proinflammatory cytokines, TRIF mediates unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IFN-inducible protein 10 (IP-10) and inducible nitric oxide synthase (iNOS).
PMID: 15075354
Ligation of TLR4 recruits TRIF and transverse rectus abdominis musculocutaneous (TRAM), mediating unique signals leading to secretion of IFN-beta and indirect up-regulation of IFN-dependent genes such as IP-10 and iNOS.
c83 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 15075354, 11431423
In this way, heterodimers of TLR2/TLR1 recognize triacetylated bacterial lipopeptides, whereas TLR2/TLR6 heterodimeres recognize diacetylated Mycoplasma lipopeptides [16 ], and similar heterodimerization is likely to occur for other PAMPs.
c91 cso30:c:InputProcess connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 15075354, 11431423
In this way, heterodimers of TLR2/TLR1 recognize triacetylated bacterial lipopeptides, whereas TLR2/TLR6 heterodimeres recognize diacetylated Mycoplasma lipopeptides [16 ], and similar heterodimerization is likely to occur for other PAMPs.
c94 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 15075354
Our recent finding that NOD2, an intracellular molecule involved in the pathogenesis of Crohn’s disease, specifically mediates cytokine induction by TLR2 but not TLR4 agonists indicates that it may be part of a TLR2-specific pathway.
c97 cso30:c:InputAssociation connector
c98 cso30:c:InputAssociation connector
c99 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 15075354, 12917260
TLR2 also mediates host defense against T. gondii by mediating cytokine and NO release.
c100 cso30:c:InputProcess connector
c102 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 15075354
MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.
c103 cso30:c:InputAssociation connector
c107 cso30:c:InputAssociation connector
c105 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 15075354
MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.
c108 cso30:c:InputAssociation connector
c110 cso30:c:InputAssociation connector
c104 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 15075354
MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.
c109 cso30:c:InputAssociation connector
c111 cso30:c:InputAssociation connector
c106 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 15075354
MyD88 is essential for the stimulation of proinflammatory cytokines such as TNF, IL-1beta, IL-12, or IL-6, virtually by the entire range of TLR agonists.
PMID: 15075354, 12761116
The stimulation of specific TLRs results in the release of IL-10 or IL-12, leading to skewing of the T cell response toward Th1 or Th2 cytokines.
c113 cso30:c:InputAssociation connector
c114 cso30:c:InputAssociation connector
c112 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 15075354, 12244183, 12055206
The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.
c115 cso30:c:InputAssociation connector
c117 cso30:c:InputAssociation connector
c116 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 15075354, 12244183, 12055206
The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.
c118 cso30:c:InputProcess connector
c122 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 15075354, 12244183, 12055206
The protective mechanisms triggered through MyD88 mainly include release of proinflammatory cytokines and of reactive nitrogen and oxygen intermediates.
c120 cso30:c:InputProcess connector
c123 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 15075354
Stimulation of immature DC by microbial stimuli induces production of proinflammatory cytokines such as TNF and IL-12, which can induce differentiation of T cells into T helper cell type 1 (Th1) cells.
c124 cso30:c:InputAssociation connector
p45_propro_p45
PMID: 15075354
Stimulation of immature DC by microbial stimuli induces production of proinflammatory cytokines such as TNF and IL-12, which can induce differentiation of T cells into T helper cell type 1 (Th1) cells.
c125 cso30:c:InputAssociation connector
p46_propro_p46
PMID: 15075354, 9521319
In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.
c129 cso30:c:InputAssociation connector
c126 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 15075354, 9521319
In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.
c130 cso30:c:InputAssociation connector
c127 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 15075354, 9521319
In addition, these stimuli induce up-regulation of costimulatory molecules such as CD40, CD80, and CD86.
c131 cso30:c:InputAssociation connector
c128 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
c132 cso30:c:InputAssociation connector
c133 cso30:c:InputAssociation connector
c134 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
c135 cso30:c:InputAssociation connector
c138 cso30:c:InputAssociation connector
c139 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
c136 cso30:c:InputAssociation connector
c137 cso30:c:InputAssociation connector
c140 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
c141 cso30:c:InputAssociation connector
p53_propro_p53
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
PMID: 15075354, 11286707
One pathway induced mainly by TLR9 is strictly dependent on MyD88, whereas another pathway induced primarily by TLR4 can induce DC maturation through a MyD88-independent mechanism.
c142 cso30:c:InputAssociation connector
p54_propro_p54
PMID: 15075354, 11286707, 11561001
A variety of microbial PAMPs are able to induce cytokine release and DC maturation: LPS through TLR4, CpG through TLR9, bacterial lipopeptides through TLR2.
c143 cso30:c:InputAssociation connector
p57_propro_p57
PMID: 15075354
Thus, whereas interaction of Candida mannan with TLR4 induces release of chemokines, leukocyte recruitment, and protection, interaction of Candida glucans and phospholipomannan with TLR2 primarily mediates release of the anti-inflammatory cytokine IL-10, resulting in inhibition of the host defense and increased susceptibility to infection.
c150 cso30:c:InputAssociation connector
c152 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 15075354, 12761116
The stimulation of specific TLRs results in the release of IL-10 or IL-12, leading to skewing of the T cell response toward Th1 or Th2 cytokines.
c144 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 15075354, 12391013
Yersinia enterocolitica and C. albicans have been shown to exploit TLR2-mediated IL-10 release to induce immunosuppression.
PMID: 15075354
Thus, whereas interaction of Candida mannan with TLR4 induces release of chemokines, leukocyte recruitment, and protection, interaction of Candida glucans and phospholipomannan with TLR2 primarily mediates release of the anti-inflammatory cytokine IL-10, resulting in inhibition of the host defense and increased susceptibility to infection.
c147 cso30:c:InputAssociation connector
c148 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
LPS_enti_MO000016882
LPS
CD14_enti_MO000018132
CD14
LPS: CD14_enti_e5
LPS: CD14
TLR4_enti_MO000019394
TLR4
LPS: CD14: TLR4_enti_e6
LPS: CD14: TLR4
CD11b: CD18_enti_e11
CD11b: CD18
LPS: CD11b: CD18_enti_e13
LPS: CD11b: CD18
LPS: CD11b: CD18: TLR4_enti_e14
LPS: CD11b: CD18: TLR4
lipoteichoic acid: CD14_enti_e12
lipoteichoic acid: CD14
lipoteichoic acid_enti_e15
lipoteichoic acid
lipoteichoic acid: CD14: TLR4_enti_e16
lipoteichoic acid: CD14: TLR4
TLR2_enti_MO000019397
TLR2
zymosan_enti_e17
zymosan
dectin-1_enti_MO000069513
dectin-1
zymosan: dectin-1_enti_e18
zymosan: dectin-1
zymosan: dectin-1: TLR2_enti_e19
zymosan: dectin-1: TLR2
PGN: TLR2_enti_e20
PGN: TLR2
PGN_enti_MO000042032
PGN
dsRNA_enti_MO000022224
dsRNA
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
Lp_enti_MO000017793
Lp
Lp: TLR2_enti_e21
Lp: TLR2
TLR3_enti_MO000019398
TLR3
Hsp_enti_MO000021891
Hsp
Hsp: TLR4_enti_e22
Hsp: TLR4
flagellin_enti_MO000022185
flagellin
TLR5_enti_MO000019399
TLR5
flagellin: TLR5_enti_e23
flagellin: TLR5
TLR9_enti_MO000042012
TLR9
CpG DNA_enti_e24
CpG DNA
CpG DNA: TLR9_enti_e25
CpG DNA: TLR9
TLRs_enti_MO000019395
TLRs
PAMP_enti_e26
PAMP
PAMP: TLR4_enti_e27
PAMP: TLR4
MyD88_enti_MO000016573
MyD88
PAMP: TLR4: MyD88_enti_e28
PAMP: TLR4: MyD88
IRAK1_enti_MO000000213
IRAK1
PAMP: TLR4: MyD88: IRAK1_enti_e29
PAMP: TLR4: MyD88: IRAK1
TRAF6_enti_MO000000212
TRAF6
NF-kappaB_enti_MO000000058
NF-kappaB
PAMP: TLR4: MyD88: IRAK1: TRAF6_enti_e30
PAMP: TLR4: MyD88: IRAK1: TRAF6
AP-1_enti_MO000000276
AP-1
NF-kappaB{activated}_enti_e31
NF-kappaB{activated}
MAPKs_enti_MO000000077
MAPKs
MAPKs{activated}_enti_e32
MAPKs{activated}
AP-1{activated}_enti_e33
AP-1{activated}
TRIF_enti_MO000041125
TRIF
TRAM_enti_MO000041132
TRAM
proinflammatory cytokines_enti_e34
proinflammatory cytokines
IFN-beta_enti_G010228
IFN-beta
Ligand: TLR4_enti_e35
Ligand: TLR4
IFNbeta_enti_MO000016660
IFNbeta
Ligand: TLR4: TRAM_enti_e36
Ligand: TLR4: TRAM
dsRNA:TLR3: TRIF_enti_e37
dsRNA:TLR3: TRIF
Ligand: TLR4: TRAM: TRIF_enti_e38
Ligand: TLR4: TRAM: TRIF
iNOS_enti_G010514
iNOS
IP-10_enti_G001062
IP-10
Nod2_enti_MO000020461
Nod2
TLR2: TLR1_enti_e39
TLR2: TLR1
TLR2: TLR6_enti_e40
TLR2: TLR6
triacetylated lipopeptides: TLR2: TLR1_enti_e41
triacetylated lipopeptides: TLR2: TLR1
diacetylated Mycoplasma lipopeptide: TLR2: TLR6_enti_e42
diacetylated Mycoplasma lipopeptide: TLR2: TLR6
triacetylated lipopeptides_enti_e43
triacetylated lipopeptides
diacetylated Mycoplasma lipopeptide_enti_e44
diacetylated Mycoplasma lipopeptide
NO_enti_e45
NO
NO{extracellular}_enti_e46
NO{extracellular}
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
IL-12_enti_MO000017265
IL-12
IL-12 p40_enti_G010657
IL-12 p40
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
cytokines_enti_MO000019387
cytokines
reactive nitrogen_enti_e47
reactive nitrogen
oxigen intermediates_enti_e48
oxigen intermediates
reactive nitrogen{extracellular}_enti_e49
reactive nitrogen{extracellular}
oxigen intermediates{extracellular}_enti_e63
oxigen intermediates{extracellular}
CD40_enti_MO000016922
CD40
CD80_enti_MO000017269
CD80
CD86_enti_MO000017270
CD86
microbial stimuli_enti_e64
microbial stimuli
IL-10{extracellular}_enti_MO000017247
IL-10{extracellular}
IL10_enti_G011345
IL10
ligand: TLR2_enti_e65
ligand: TLR2
chemokine_enti_e66
chemokine
chemokines_enti_MO000000265
chemokines