1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15081522.csml convertedTime:2009.07.01.10:45

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?
Authors Jefferies CA, O'Neill LA.
Affiliation Department of Biochemistry and Biotechnology Institute, Cytokine Research Group,Trinity College, Dublin 2, Ireland. jefferca@tcd.ie
Abstract The discovery of the Toll-like receptors (TLRs) has revolutionised the field ofinnate immunity. One unresolved question regarding LPS signalling is whetherthere is a role for tyrosine kinases downstream of the LPS receptor. Studies inmice deficient in Bruton's tyrosine kinase have previously shown that they aredefective in their responses to LPS. Further investigation into the role of Btkin LPS signalling has directly implicated Btk downstream of TLR4, both withrespect to p38 MAPK activation and activation of the transcription factorNFkappaB. In fact Btk is activated by LPS and has been shown to directly bindTLR4 and the key proximal signalling proteins involved in LPS-induced NFkappaBactivation, MyD88, Mal and IRAK-1. These recent findings point to a direct rolefor Btk in LPS signal transduction and raise interesting questions regarding themode of activation of Btk following LPS stimulation and the precise nature ofthe pathways activated downstream of Btk. A better understanding of how Btkfunctions in LPS signalling will have important implications for inflammatoryand autoimmune disorders and therapies thereof.
PMID 15081522
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010514:iNOS MO000000012:Grb-2 MO000000022:p38 MO000000023:JNK MO000000030:PI3K{active} MO000000044:Vav MO000000058:NF-kappaB MO000000085:Src MO000000088:IL-3R MO000000089:IL-5R MO000000102:PLCgamma MO000000104:PKC{active} MO000000144:Lyn MO000000206:TNFR1 MO000000210:IKK-alpha MO000000211:IKK-beta MO000000213:IRAK MO000000214:IL-1 MO000000215:IkappaB MO000000248:IKK MO000000276:AP-1{active} MO000000289:TNF-alpha MO000000332:IP3 MO000001935:Btk MO000007384:IL-6 MO000007694:IRF-3 MO000016573:MyD88 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016695:DAG MO000016872:c-Cbl MO000016882:LPS MO000017012:IL-3 MO000017013:IL-5 MO000017272:PIP3 MO000017529:paxillin{active} MO000017690:BCR MO000017705:FcepsilonRI MO000017822:TFII-I MO000017825:SAB MO000018132:CD14 MO000018134:G-proteins MO000018458:IL-6R MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019479:protein remnants MO000019592:F-actin MO000021201:iNOS MO000022131:MD-2 MO000022224:dsRNA MO000022528:TIRAP MO000038687:(TNF-alpha)3:(TNFR1)3 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000063687:IBTK MO000066028:BLNK e1: e10: e100:TLR8:Btk e101:MyD88{p} e102:BLNK:Grb-2:Vav:PLCgamma e103:IL-6:IL-6R e104:PKC e11:NFKappaB:IKappaB{P} e12:NFKappaB:IKappaB{p}{ub} e14:NF-kappaB{active} e15:NF-kappaB{active} e16:TLR4:MD-2:CD14 e17:LPS:TLR4 e18:Btk:PIP3 e19:Btk:PIP3 e2: e20:MyD88:PI3K e22:Btk:F-actin e23:Btk:G-protein e24:Btk:F-actin e25:Btk:G-protein e26:PI3K e27:LPS:TLR4:MyD88 e28:LPS:TLR4:MyD88:TIRAP e3: e30:TLR2:peptidoglycans e31:IRF-3{active} e32:LPS:TLR4:TRAM e33:LPS:TLR4:TRAM:TRIF e34:Src Kinases{active} e36:PTKs e37:hypomethylated DNA e38:TLR9:DNA e39:B Cell antigen e4: e40:BCR:antigen e43:Il-1R e44:IL-1:IL-1R e46:LPS:TLR4:MyD88:TIRAP:IRAK1:Btk{active} e47:LPS:TLR4:MyD88:TIRAP:IRAK1 e48:LPS:TLR4:MyD88:TIRAP:IRAK1:Btk e49:IL-5:IL-5R e5:NF-KappaB:IKappaB e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IKK{active} e60: e61: e62: e64:Btk{p}:PIP3 e65:Btk{p}:PIP3 e66:Vav{active} e67:PLCgamma{p} e68:paxillin e69:focal adhesion protein e7: e70:focal adhesion protein{active} e71: e72: e73: e74: e75: e76: e77:calcium e78:calcium e8: e80:JNK{active} e81:p38{active} e82:AP-1 e83:Btk:PLCgamma e84:Btk:Vav e85:Btk:Grb-2 e86:Btk:TFII-I e87:IL-3:IL-3R e88:Btk{active} e89:G-protein:receptor e9: e91:FcepsilonRI antigen e92:FcepsilonRI:receptor e93:Btk:PIP3:IBTK e94:Btk:PIP3:SAB e95:Btk:BLNK e96:Btk:PIP3:c-Cbl e97:Bright e98:Btk:bright e99:TLR4:Btk

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p9
Model Detail
477.0, 1015.0
34.0, 34.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27 p28

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
579.0, 1173.0
30.0, 30.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p37

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
594.0, 1000.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p34 p38

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
588.0, 1106.0
35.0, 35.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
596.0, 1054.0
28.0, 28.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p35

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
356.0, 446.0
27.0, 27.0

Grb-2

--

MO000000012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p85

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000012

--

Go back
557.0, 639.0
26.0, 26.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
680.0, 642.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
762.0, 158.0
27.0, 27.0

PI3K{active}

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p80 p81

p12 p18

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
323.0, 217.0
30.0, 30.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p62 p85

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
411.0, 565.0
29.0, 29.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p25 p32 p41 p43 p59

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
929.0, 809.0
29.0, 29.0

Src

--

MO000000085

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
191.0, 853.0
30.0, 30.0

IL-3R

--

MO000000088

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m95

10

false

infinite

0

unit false false false
TRANSPATHMO000000088

--

Go back
129.0, 1215.0
26.0, 26.0

IL-5R

--

MO000000089

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000000089

--

Go back
841.0, 627.0
26.0, 26.0

PLCgamma

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p61 p85

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
466.0, 836.0
32.0, 32.0

PKC{active}

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56

--

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
865.0, 565.0
29.0, 29.0

Lyn

--

MO000000144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
1028.0, 876.0
31.0, 31.0

TNFR1

--

MO000000206

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m177

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000000206

--

Go back
825.0, 439.0
26.0, 26.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
793.0, 483.0
26.0, 26.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
874.0, 330.0
27.5, 27.5

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
123.0, 733.0
29.5, 29.5

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
455.0, 513.0
29.0, 29.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
681.0, 591.0
26.0, 26.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3 p79

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
645.0, 883.0
26.0, 26.0

AP-1{active}

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

--

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1124.0, 950.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p38

p40

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
948.0, 1082.0
28.0, 28.0

IP3

--

MO000000332

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54

true true true true

csml-variable:Double

m290230

10

false

infinite

0

unit false false false
TRANSPATHMO000000332

--

Go back
586.0, 234.0
28.0, 28.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p13 p14 p46 p61 p62 p63 p64 p68 p69 p71 p72 p75 p78 p73 p82 p84

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
1137.0, 1191.0
26.0, 26.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p70

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
345.0, 391.0
26.0, 26.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p31

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
572.0, 174.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p83

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1135.0, 1125.0
29.0, 29.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
748.0, 434.0
28.0, 28.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
653.0, 737.0
30.0, 30.0

DAG

--

MO000016695

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p56

true true true true

csml-variable:Double

m290231

10

false

infinite

0

unit false false false
TRANSPATHMO000016695

--

Go back
738.0, 1028.0
24.0, 24.0

c-Cbl

--

MO000016872

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m1795

10

false

infinite

0

unit false false false
InterProIPR000449
TRANSPATHMO000016872

--

Go back
635.0, 33.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
124.0, 818.0
28.0, 28.0

IL-3

--

MO000017012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m1912

10

false

infinite

0

unit false false false
InterProIPR002183
TRANSPATHMO000017012

--

Go back
193.0, 1183.0
26.0, 26.0

IL-5

--

MO000017013

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m1913

10

false

infinite

0

unit false false false
InterProIPR000186
TRANSPATHMO000017013

--

Go back
986.0, 322.0
28.0, 28.0

PIP3

--

MO000017272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p10

true true true true

csml-variable:Double

m157492

10

false

infinite

0

unit false false false
TRANSPATHMO000017272

--

Go back
505.0, 419.0
26.0, 26.0

paxillin{active}

--

MO000017529

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m2323

10

false

infinite

0

unit false false false
InterProIPR001179
TRANSPATHMO000017529

--

Go back
1031.0, 657.0
30.5, 30.5

BCR

--

MO000017690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m2450

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
403.0, 1343.0
33.0, 33.0

FcepsilonRI

--

MO000017705

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m2465

10

false

infinite

0

unit false false false
TRANSPATHMO000017705

--

Go back
665.0, 339.0
26.0, 26.0

TFII-I

--

MO000017822

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m2574

10

false

infinite

0

unit false false false
TRANSPATHMO000017822

--

Go back
724.0, 950.0
28.0, 28.0

SAB

--

MO000017825

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m2577

10

false

infinite

0

unit false false false
InterProIPR007940
TRANSPATHMO000017825

--

Go back
457.0, 103.0
26.0, 26.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p8

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
291.0, 175.0
26.0, 26.0

G-proteins

--

MO000018134

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m2830

10

false

infinite

0

unit false false false
TRANSPATHMO000018134

--

Go back
1029.0, 1305.0
30.5, 30.5

IL-6R

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m3096

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
392.0, 102.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p73

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
205.0, 207.0
25.0, 25.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
200.0, 338.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
361.0, 733.0
29.0, 29.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
252.0, 382.0
28.0, 28.0

F-actin

--

MO000019592

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m4136

10

false

infinite

0

unit false false false
TRANSPATHMO000019592

--

Go back
1124.0, 1046.0
36.0, 36.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
317.0, 43.0
25.0, 25.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p8

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
137.0, 315.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
826.0, 288.0
24.0, 24.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1026.0, 798.0
35.0, 35.0

(TNF-alpha)3:(TNFR1)3

--

MO000038687

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p41

true true true true

csml-variable:Double

m16874

10

false

infinite

0

unit false false false
TRANSPATHMO000038687

--

Go back
289.0, 431.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p30

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
349.0, 179.0
26.0, 26.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
188.0, 494.0
36.0, 36.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p25 p26

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
203.0, 409.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p24

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
194.0, 552.0
32.0, 32.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
196.0, 1002.0
28.0, 28.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
122.0, 206.0
28.0, 28.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
722.0, 892.0
24.0, 24.0

IBTK

--

MO000063687

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m38562

10

false

infinite

0

unit false false false
TRANSPATHMO000063687

--

Go back
977.0, 199.0
26.0, 26.0

BLNK

--

MO000066028

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84 p85

true true true true

csml-variable:Double

m40889

10

false

infinite

0

unit false false false
TRANSPATHMO000066028

--

Go back
173.86994746207097, 83.29177467732318
904.5780429447777, 1313.4473183558166

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
243.69439475002247, 153.77574210575966
828.1222093235541, 1164.9350933309531

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
194.5, 605.0
23.6730980048235, 45.81889936417452

TLR8:Btk

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p82

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
635.0, 221.0
22.0, 22.0

MyD88{p}

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p12

true true true true

csml-variable:Double

m111

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
951.0, 389.0
22.85294117647059, 38.08823529411766

BLNK:Grb-2:Vav:PLCgamma

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1030.5, 1217.0
27.7103705327779, 53.63297522473142

IL-6:IL-6R

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

p71

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
556.0, 868.0
32.0, 32.0

PKC

--

e104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m114

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
463.5, 626.0
29.66455590734877, 36.323946008998504

NFKappaB:IKappaB{P}

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
350.0, 665.0
39.90902729181246, 30.59692092372288

NFKappaB:IKappaB{p}{ub}

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
303.0, 817.0
29.0, 29.0

NF-kappaB{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p25 p32 p41 p43 p59

p7

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
383.0, 997.0
29.0, 29.0

NF-kappaB{active}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p27

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
560.5, 94.0
26.136171774637557, 36.4690768948431

TLR4:MD-2:CD14

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
663.5, 96.0
21.158298618723965, 40.951545713659286

LPS:TLR4

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p17 p19 p29 p33 p34 p35 p36 p37 p38 p49 p50 p51 p83

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
841.5, 405.0
24.60206632227961, 30.12497917013832

Btk:PIP3

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
1029.5, 416.0
25.892184635894015, 31.704715880686564

Btk:PIP3

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p47

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
173.86994746207097, 83.29177467732318
904.5780429447777, 1313.4473183558166

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
856.5, 239.0
23.409931678053663, 28.665222462922852

MyD88:PI3K

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
577.5, 493.0
24.520413264455925, 30.024995834027663

Btk:F-actin

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
454.5, 266.0
23.360939843359443, 28.605232461256456

Btk:G-protein

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1029.5, 473.0
25.23079486752208, 30.894850858190303

Btk:F-actin

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1027.5, 367.0
28.080486585569073, 34.384269288451925

Btk:G-protein

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
484.0, 158.0
27.0, 27.0

PI3K

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p80 p81

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
771.5, 95.0
29.663608001468162, 41.391080932281156

LPS:TLR4:MyD88

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
913.0, 90.0
26.647058823529417, 44.41176470588236

LPS:TLR4:MyD88:TIRAP

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p20

p44

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
191.96150832096646, 101.38333553621877
868.3949212269863, 1277.264196638026

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
205.5, 256.0
24.291602718702038, 47.016005262003944

TLR2:peptidoglycans

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p80

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
637.0, 571.0
26.0, 26.0

IRF-3{active}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p31

p28

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
248.5, 93.0
26.885850614791703, 37.51514039273261

LPS:TLR4:TRAM

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
196.0, 125.0
27.264705882352928, 45.44117647058823

LPS:TLR4:TRAM:TRIF

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31 p32

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
974.0, 901.0
16.550982226379794, 38.19457436856875

Src Kinases{active}

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p33

p34 p35

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
787.0, 1220.5
29.76, 22.320000000000004

PTKs

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36 p37 p38

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
123.0, 1112.5
45.63998990154001, 14.452663468821004

hypomethylated DNA

--

e37

cso30:c:Dna

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p23

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
197.5, 1084.0
25.23635167726376, 48.84455163341372

TLR9:DNA

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p81

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1107.0, 647.5
37.2231985940246, 24.195079086115992

B Cell antigen

--

e39

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
225.43089590992344, 133.04356703928588
801.4561460490727, 1213.943733631892

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1030.5, 714.0
22.83030037272528, 44.18767814075861

BCR:antigen

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p47

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
194.5, 741.0
30.06678383128295, 46.256590509666076

Il-1R

--

e43

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p42

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
198.5, 665.0
23.815829861872395, 46.095154571365924

IL-1:IL-1R

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1033.0, 290.0
26.647058823529417, 44.41176470588236

LPS:TLR4:MyD88:TIRAP:IRAK1:Btk{active}

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p45

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1033.0, 90.0
26.647058823529417, 44.41176470588236

LPS:TLR4:MyD88:TIRAP:IRAK1

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p44

p46

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1029.0, 182.0
26.647058823529417, 44.41176470588236

LPS:TLR4:MyD88:TIRAP:IRAK1:Btk

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p46

p45

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
197.5, 1273.0
24.264415698311772, 46.963385222538925

IL-5:IL-5R

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p67

p69

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
615.5, 607.0
28.080486585569073, 34.38426928845192

NF-KappaB:IKappaB

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
259.5851682871582, 883.8263779177634
452.4345550535624, 410.30843260909757

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
308.4514703227384, 893.5500912759621
264.55204895124524, 397.670595875758

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
265.4828254293833, 889.302773835544
440.63924076911206, 399.35564077353644

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
266.3253478782726, 890.1452962844329
438.9541958713335, 397.670595875758

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
259.5851682871582, 883.8263779177634
452.4345550535624, 410.30843260909757

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
259.5851682871582, 883.8263779177634
452.4345550535624, 410.30843260909757

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
266.3253478782726, 890.1452962844329
438.9541958713335, 397.670595875758

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
589.8539682517699, 1052.3308676956267
28.265625096240672, 25.58782903449166

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
515.7119927495098, 1170.2840105401312
80.03963264448502, 72.45693060448127

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
259.5851682871582, 883.8263779177634
452.4345550535624, 410.30843260909757

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
593.0, 687.0
26.0, 26.0

IKK{active}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p79

p4

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
366.2214472392645, 1066.1640549627555
14.32793757579902, 6.8986366105699215

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
365.742996847212, 1045.5906881045123
49.04116518534977, 88.27409733362977

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
386.31636370545675, 1103.0047351507756
7.655206272835076, 7.6552062728351

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1029.5, 528.0
25.892184635894015, 31.704715880686564

Btk{p}:PIP3

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1033.5, 588.0
25.892184635894015, 31.704715880686564

Btk{p}:PIP3

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p52 p57 p58 p60 p66 p76 p77 p79

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
331.0, 349.0
30.0, 30.0

Vav{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
881.0, 683.0
26.0, 26.0

PLCgamma{p}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53 p55

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
417.0, 207.0
26.0, 26.0

paxillin

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR001179
TRANSPATHMO000017529

--

Go back
595.0, 335.0
14.471468662301218, 33.395696913002794

focal adhesion protein

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
188.58330599604193, 88.50093114555817
874.309794076218, 1238.8743945581841

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
655.0, 495.0
14.471468662301218, 33.395696913002794

focal adhesion protein{active}

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

p51

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
817.0136419185845, 1261.543805716343
161.00210312911716, 45.31516147673831

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
814.6146039580514, 1259.1447677558099
165.80017905018343, 50.11323739780474

--

e72

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
817.5467614653696, 1262.0769252631285
159.93586403554676, 44.248922383167994

--

e73

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false true false

--

Go back
814.6146039580514, 1259.1447677558099
165.80017905018343, 50.11323739780474

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
814.6146039580514, 1259.1447677558099
165.80017905018343, 50.11323739780474

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
816.2139625984069, 1260.744126396165
162.60146176947256, 46.91452011709375

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
963.5, 1209.0
24.73817257449512, 25.157463635079782

calcium

--

e77

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
879.5, 1269.0
22.788447959327772, 23.174692839994346

calcium

--

e78

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
191.70686827176752, 110.3658670756373
838.7358035320548, 1217.844386728544

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
632.0, 786.0
28.0, 28.0

JNK{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
407.0, 811.0
26.0, 26.0

p38{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58

p59

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
789.0, 779.0
26.0, 26.0

AP-1

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
804.2115480753209, 535.0
27.28845192467922, 33.414430928178625

Btk:PLCgamma

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
321.5, 293.0
24.161139810031667, 29.585069155140815

Btk:Vav

--

e84

cso30:c:Complex

cso30:i:CC_Extracellular

--

p62

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
500.5, 496.0
26.91284785869022, 32.95450758206966

Btk:Grb-2

--

e85

cso30:c:Complex

cso30:i:CC_Extracellular

--

p63

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
578.5, 418.0
23.630394934177637, 28.935177470421593

Btk:TFII-I

--

e86

cso30:c:Complex

cso30:i:CC_Extracellular

--

p64

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
198.5, 922.0
22.78951984213988, 44.10874808156107

IL-3:IL-3R

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p65

p68

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
374.0, 860.0
24.0, 24.0

Btk{active}

--

e88

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68 p69 p71 p72 p75

--

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
618.5, 1337.0
23.367244025433017, 45.226923920192945

G-protein:receptor

--

e89

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p72

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
209.03636767370242, 135.23080300571638
834.9065145134958, 1201.8726627607905

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
426.0, 1427.5
39.22671353251318, 25.497363796133566

FcepsilonRI antigen

--

e91

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p74

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
302.5, 1335.0
22.184608638456478, 42.93795220346416

FcepsilonRI:receptor

--

e92

cso30:c:Complex

cso30:i:CC_Extracellular

--

p74

p75

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1036.5, 989.0
26.95687282070105, 37.61424114516425

Btk:PIP3:IBTK

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

p52

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1040.5, 1081.0
27.619746742521563, 38.53918150119288

Btk:PIP3:SAB

--

e94

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p76

p52

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
981.5, 237.0
24.250958173637724, 29.695050824862527

Btk:BLNK

--

e95

cso30:c:Complex

cso30:i:CC_Extracellular

--

p84

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1033.5, 1159.0
24.66048816296569, 34.40998348320794

Btk:PIP3:c-Cbl

--

e96

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p77

p52

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
615.0, 456.5
30.080000000000005, 22.560000000000002

Bright

--

e97

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p78

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
699.5, 458.0
29.321613064489245, 35.90401599733377

Btk:bright

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
331.5, 95.0
21.409778557333922, 41.438281078710816

TLR4:Btk

--

e99

cso30:c:Complex

cso30:i:CC_Extracellular

--

p73

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
478.0, 576.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000058 MO000000215

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m186*0.1

nodelay

--

true

0

false

PMID: 15081522 It (NF-KappaB) is retained in the cytosol in a negative conformation by the inhibitory protein, IKappaB.

Go back
750.0, 288.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000017272

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m367*m157492*0.1

nodelay

--

true

0

false

PMID:15081522 The PH domain of Btk binds selectively to the phosphatidylinositol 3-kinase (PI3K) product PIP3, any increase in which therefore promotes membrane recruitment of Btk.

Go back
927.0, 429.0
21.0, 21.0

p11

p11

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 15081522 Importantly, membrane targeting of Btk is the first step and a prerequisite for its activation. PMID:15081522 The PH domain of Btk binds selectively to the phosphatidylinositol 3-kinase (PI3K) product PIP3, any increase in which therefore promotes membrane recruitment of Btk.

Go back
758.0, 228.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000030 e101

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c247 : 1
stoichiometry:c36 : 1

m27*m111*0.1

nodelay

--

true

0

false

PMID: 15081522 With respect to TLR4 signalling, PI3K has been shown to interact with the adaptor protein MyD88 PMID: 15081522 Specifically, MyD88 has been shown to become tyrosine phosphorylated after LPS stimulation, which stimulates an interaction between the newly phosphorlyated tyrosine on MyD88 and the SH2 domain of p85 PI3K and MyD88.

Go back
547.0, 365.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000019592

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m367*m4136*0.1

nodelay

--

true

0

false

PMID:15081522 An additional means of membrane targeting appears to be mediated by direct interaction between the PH domain of Btk and the G-protein beta-gamma subunits and F-actin, suggesting multiple potential mechanisms for regulating Btk localisation and juxtaposition with activating kinases.

Go back
481.0, 343.0
25.0, 25.0

p13

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000018134

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c59 : 1
stoichiometry:c42 : 1

m367*m2830*0.1

nodelay

--

true

0

false

PMID:15081522 An additional means of membrane targeting appears to be mediated by direct interaction between the PH domain of Btk and the G-protein beta-gamma subunits and F-actin, suggesting multiple potential mechanisms for regulating Btk localisation and juxtaposition with activating kinases.

Go back
903.0, 457.0
21.0, 21.0

p15

p15

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m23*0.1

nodelay

--

true

0

false

PMID:15081522 An additional means of membrane targeting appears to be mediated by direct interaction between the PH domain of Btk and the G-protein beta-gamma subunits and F-actin, suggesting multiple potential mechanisms for regulating Btk localisation and juxtaposition with activating kinases.

Go back
929.0, 353.0
21.0, 21.0

p15

p16

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m24*0.1

nodelay

--

true

0

false

PMID:15081522 An additional means of membrane targeting appears to be mediated by direct interaction between the PH domain of Btk and the G-protein beta-gamma subunits and F-actin, suggesting multiple potential mechanisms for regulating Btk localisation and juxtaposition with activating kinases.

Go back
541.0, 225.0
21.0, 21.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e26

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m18*m28*0.1

nodelay

--

true

0

false

PMID: 15081522 PI3K is activated by multiple TLR members, most notably TLR2, TLR4 and TLR9, resulting in increased PIP3 production.

Go back
672.0, 300.0
23.0, 23.0

p18

p18

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000000030

MO000017272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 15081522 PI3K is activated by multiple TLR members, most notably TLR2, TLR4 and TLR9, resulting in increased PIP3 production.

Go back
713.0, 157.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m18*m1572*0.1

nodelay

--

true

0

false

PMID: 15081522 Immunoprecipitation experiments in the human pro-monocytic cell line, THP-1, revealed that Btk interacted with MyD88, Mal and IRAK-1, key proximal effectors involved in TLR4 signalling

Go back
678.0, 524.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000000211 MO000000210

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m1593*m182*m181*0.1

nodelay

--

true

0

false

PMID: 15081522 Activation of cells by appropriate stimuli activates an upstream kinase complex comprising IKK- (IKappaB kinases-) 1 and 2 in complex with a scaffold protein IKK-gamma.

Go back
791.0, 189.0
21.0, 21.0

p19

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000022528

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m29*m6810*0.1

nodelay

--

true

0

false

PMID: 15081522 Immunoprecipitation experiments in the human pro-monocytic cell line, THP-1, revealed that Btk interacted with MyD88, Mal and IRAK-1, key proximal effectors involved in TLR4 signalling

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133.0, 275.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000042032

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c134 : 1
stoichiometry:c60 : 1

m3964*m155701*0.1

nodelay

--

true

0

false

PMID: 15081522 Of the 10 human TLR members, ligands for all but TLR10 have been described, with TLR2 recognising peptidoglycan, TLR3 recognising double stranded viral RNA and TLR9 recognising bacterial hypomethylated DNA motifs, for example

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129.0, 363.0
25.0, 25.0

p21

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15081522 Of the 10 human TLR members, ligands for all but TLR10 have been described, with TLR2 recognising peptidoglycan, TLR3 recognising double stranded viral RNA and TLR9 recognising bacterial hypomethylated DNA motifs, for example

Go back
133.0, 991.0
25.0, 25.0

p21

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000042012

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m39*m19828*0.1

nodelay

--

true

0

false

PMID: 15081522 Of the 10 human TLR members, ligands for all but TLR10 have been described, with TLR2 recognising peptidoglycan, TLR3 recognising double stranded viral RNA and TLR9 recognising bacterial hypomethylated DNA motifs, for example

Go back
149.0, 451.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 15081522,12471095,12539043 The third adapter identified, Trif (also known as TICAM-1), interacts with TLR3 and mediates TLR3-dependent induction of IFN-beta via NFKappaB and IRF-3 activation

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326.0, 572.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m19305*m5*0.1

nodelay

--

true

0

false

PMID: 15081522,12471095,12539043 The third adapter identified, Trif (also known as TICAM-1), interacts with TLR3 and mediates TLR3-dependent induction of IFN-beta via NFKappaB and IRF-3 activation

Go back
386.0, 504.0
23.0, 23.0

p25

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 MO000007694

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m19305*m977*0.1

nodelay

--

true

0

false

PMID: 15081522,12471095,12539043 The third adapter identified, Trif (also known as TICAM-1), interacts with TLR3 and mediates TLR3-dependent induction of IFN-beta via NFKappaB and IRF-3 activation

Go back
482.0, 916.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e15

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15081522,12471095,12539043 The third adapter identified, Trif (also known as TICAM-1), interacts with TLR3 and mediates TLR3-dependent induction of IFN-beta via NFKappaB and IRF-3 activation

Go back
574.0, 952.0
23.0, 23.0

p27

p28

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e31

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15081522,12471095,12539043 The third adapter identified, Trif (also known as TICAM-1), interacts with TLR3 and mediates TLR3-dependent induction of IFN-beta via NFKappaB and IRF-3 activation

Go back
402.0, 172.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000041132

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m18*m19005*0.1

nodelay

--

true

0

false

PMID: 15081522,14517278 Meanwhile, a fourth adapter has recently been characterised, TRAM (TRIF-related adaptor molecule), which, unlike any of the other adaptors, is specific for TLR4 signalling and regulates the MyD88-independent pathway to NFKappaB and IRF-3 activation PMID:15081522,14556004 It also regulates late NFKappaB activation in response to TLR4

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747.0, 665.0
21.0, 21.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m207*0.1

nodelay

--

true

0

false

PMID: 15081522 Activation of cells by appropriate stimuli activates an upstream kinase complex comprising IKK- (IKappaB kinases-) 1 and 2 in complex with a scaffold protein IKK-gamma.

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250.0, 300.0
23.0, 23.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m18998*m34*0.1

nodelay

--

true

0

false

PMID:15081522 Trif is also involved in the MyD88-independent pathway activated by TLR4

Go back
410.0, 412.0
23.0, 23.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 MO000007694

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m35*m977*0.1

nodelay

--

true

0

false

PMID: 15081522,14517278 Meanwhile, a fourth adapter has recently been characterised, TRAM (TRIF-related adaptor molecule), which, unlike any of the other adaptors, is specific for TLR4 signalling and regulates the MyD88-independent pathway to NFKappaB and IRF-3 activation

Go back
366.0, 528.0
23.0, 23.0

p31

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m35*m5*0.1

nodelay

--

true

0

false

PMID: 15081522,14517278 Meanwhile, a fourth adapter has recently been characterised, TRAM (TRIF-related adaptor molecule), which, unlike any of the other adaptors, is specific for TLR4 signalling and regulates the MyD88-independent pathway to NFKappaB and IRF-3 activation PMID:15081522,14556004 It also regulates late NFKappaB activation in response to TLR4 PMID: 15081522 NFkappaB is a key pro-inflammatory transcription factor activated in response to many stimuli, perhaps the most studied of which include LPS, IL-1 and TNFalpha

Go back
875.0, 793.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000000085

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c41 : 1
stoichiometry:c91 : 1

m18*m22*0.1

nodelay

--

true

0

false

PMID: 15081522,7515809 Later work showed that Src kinases were activated by LPS (specifically Hck and Lyn) and preceded LPS-induced TNFalpha production in monocytes

Go back
904.0, 974.0
27.0, 27.0

p34

p34

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e17 e34

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c103 : 1
stoichiometry:c94 : 1

m93309*m18*m36*0.1

nodelay

--

true

0

false

PMID: 15081522,7515809 Later work showed that Src kinases were activated by LPS (specifically Hck and Lyn) and preceded LPS-induced TNFalpha production in monocytes PMID:15081522,10565609 Other reports directly implicated Src kinases in LPS signalling to TNFalpha and iNOS (inducible-nitric oxide synthase) induction with the use of the Src-selective inhibitor, PP1, in murine macrophages

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896.0, 1038.0
27.0, 27.0

p34

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514 e17 e34

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c104 : 1
stoichiometry:c96 : 1

m93479*m18*m36*0.1

nodelay

--

true

0

false

PMID:15081522,10565609 Other reports directly implicated Src kinases in LPS signalling to TNFalpha and iNOS (inducible-nitric oxide synthase) induction with the use of the Src-selective inhibitor, PP1, in murine macrophages

Go back
892.0, 1106.0
27.0, 27.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e17 e36

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c110 : 1
stoichiometry:c101 : 1

m93364*m18*m38*0.1

nodelay

--

true

0

false

PMID:15081522,8258685 This was followed closely by reports showing that PTKs were required for the induction of pro-inflammatory cytokines (IL-1beta, IL-6 and TNFalpha) in response to LPS in murine macrophages

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852.0, 1174.0
27.0, 27.0

p36

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e17 e36

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c105 : 1
stoichiometry:c109 : 1
stoichiometry:c99 : 1

m93248*m18*m38*0.1

nodelay

--

true

0

false

PMID:15081522,8258685 This was followed closely by reports showing that PTKs were required for the induction of pro-inflammatory cytokines (IL-1beta, IL-6 and TNFalpha) in response to LPS in murine macrophages

Go back
760.0, 814.0
27.0, 27.0

p36

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e36 e17

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c111 : 1
stoichiometry:c107 : 1

m93309*m38*m18*0.1

nodelay

--

true

0

false

PMID:15081522,8258685 This was followed closely by reports showing that PTKs were required for the induction of pro-inflammatory cytokines (IL-1beta, IL-6 and TNFalpha) in response to LPS in murine macrophages

Go back
1110.0, 724.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000017690

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m41*m2450*0.1

nodelay

--

true

0

false

PMID: 15081522 One of the key consequences of BCR stimulation is activation of the transcription factor NFKappaB and consequent induction of genes regulating cell survival and proliferation

Go back
468.0, 746.0
27.0, 27.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m11*m6*0.1

nodelay

--

true

0

false

PMID:15081522 This results in phosphorylation of IKappaB on serines 32 and 36, which targets it for ubiquitination and subsequent degradation.

Go back
1154.0, 868.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 MO000000206

MO000038687

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c90 : 1
stoichiometry:c118 : 1

m230*m177*0.1

nodelay

--

true

0

false

PMID: 15081522 NFkappaB is a key pro-inflammatory transcription factor activated in response to many stimuli, perhaps the most studied of which include LPS, IL-1 and TNFalpha

Go back
618.0, 520.0
23.0, 23.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000038687

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c164 : 1
stoichiometry:c123 : 1

m5*m16874*0.1

nodelay

--

true

0

false

PMID: 15081522 NFkappaB is a key pro-inflammatory transcription factor activated in response to many stimuli, perhaps the most studied of which include LPS, IL-1 and TNFalpha

Go back
125.0, 655.0
25.0, 25.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000214 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m185*m45*0.1

nodelay

--

true

0

false

PMID: 15081522 NFkappaB is a key pro-inflammatory transcription factor activated in response to many stimuli, perhaps the most studied of which include LPS, IL-1 and TNFalpha

Go back
278.0, 620.0
23.0, 23.0

p41

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m46*m5*0.1

nodelay

--

true

0

false

PMID: 15081522 NFkappaB is a key pro-inflammatory transcription factor activated in response to many stimuli, perhaps the most studied of which include LPS, IL-1 and TNFalpha

Go back
907.0, 289.0
21.0, 21.0

p19

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000000213

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c139 : 1
stoichiometry:c135 : 1

m30*m184*0.1

nodelay

--

true

0

false

PMID: 15081522 Immunoprecipitation experiments in the human pro-monocytic cell line, THP-1, revealed that Btk interacted with MyD88, Mal and IRAK-1, key proximal effectors involved in TLR4 signalling

Go back
938.0, 280.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 15081522 However, given the ability of Btk to associate with TLR4 and key proximal signalling components of the receptor complex it is possible that these interactions promote membrane localisation and Btk activation.

Go back
775.0, 265.0
21.0, 21.0

p19

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m367*m49*0.1

nodelay

--

true

0

false

PMID: 15081522 Immunoprecipitation experiments in the human pro-monocytic cell line, THP-1, revealed that Btk interacted with MyD88, Mal and IRAK-1, key proximal effectors involved in TLR4 signalling

Go back
871.0, 509.0
21.0, 21.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e19 e40 MO000000144

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c153 : 1
stoichiometry:c163 : 1
stoichiometry:c141 : 1

m20*m42*m128*0.1

nodelay

--

true

0

false

PMID: 15081522,9188445 Src kinases such as Lyn are responsible for transphosphorylation of Btk

Go back
925.0, 571.0
25.0, 25.0

p48

p48

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15081522 This transphosphorylation event results in the autophosphorylation of tyrosine 223 in the SH3 domain of Btk, and subsequent activation of downstream signalling pathways.

Go back
382.0, 272.0
23.0, 23.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000000044

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m18*m73*0.1

nodelay

--

true

0

false

PMID: 15081522 However, other tyrosine kinases are activated following TLR4 ligation¡½these include the proto-oncogene Vav and kinases associated with focal adhesions such as paxillin and focal adhesion kinase

Go back
416.0, 662.0
27.0, 27.0

p5

p5

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m12*0.1

nodelay

--

true

0

false

PMID:15081522 This results in phosphorylation of IKappaB on serines 32 and 36, which targets it for ubiquitination and subsequent degradation.

Go back
502.0, 300.0
23.0, 23.0

p49

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e68

MO000017529

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m18*m70*0.1

nodelay

--

true

0

false

PMID: 15081522 However, other tyrosine kinases are activated following TLR4 ligation¡½these include the proto-oncogene Vav and kinases associated with focal adhesions such as paxillin and focal adhesion kinase

Go back
618.0, 300.0
23.0, 23.0

p49

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m18*m71*0.1

nodelay

--

true

0

false

PMID: 15081522 However, other tyrosine kinases are activated following TLR4 ligation¡½these include the proto-oncogene Vav and kinases associated with focal adhesions such as paxillin and focal adhesion kinase

Go back
915.0, 637.0
23.0, 23.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e65 MO000000102 e93 e94 e96

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c221 : 1
stoichiometry:c225 : 1
stoichiometry:c229 : 1
stoichiometry:c156 : 1

m67*m90*0.1

nodelay

--

true

0

false

PMID: 15081522,9763609 Following BCR-induced activation of Btk, PLCgamma becomes phosphorylated with subsequent production of IP3, mobilisation of intracellular Ca2+ stores and activation of PKC via diacylglycerol (DAG). PMID:15081522 A number of proteins have been identified that bind Btk and negatively regulate its function. These include the recently identified IBtk (inhibitor of Btk), a 26 kDa protein identified in a yeast-two-hybrid screen using Btk as a bait. PMID:15081522 Another negative regulator of Btk activity is the protein Sab, which binds the SH3 domain of Btk (constitutively) and directly inhibits kinase activity. PMID: 15081522,7629518 The SH3 domain of Btk has also been shown to interact with c-Cbl, a multi-domain-containing protein. c-Cbl may also function to negatively regulate Btk activity in cells

Go back
890.0, 740.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e67

MO000000332

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15081522,9763609 Following BCR-induced activation of Btk, PLCgamma becomes phosphorylated with subsequent production of IP3, mobilisation of intracellular Ca2+ stores and activation of PKC via diacylglycerol (DAG).

Go back
925.0, 1147.0
25.0, 25.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000332 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m290230*m80*0.1

nodelay

--

true

0

false

PMID: 15081522,9763609 Following BCR-induced activation of Btk, PLCgamma becomes phosphorylated with subsequent production of IP3, mobilisation of intracellular Ca2+ stores and activation of PKC via diacylglycerol (DAG).

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716.0, 700.0
23.0, 23.0

p55

p55

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e67

MO000016695

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c258 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15081522,9763609 Following BCR-induced activation of Btk, PLCgamma becomes phosphorylated with subsequent production of IP3, mobilisation of intracellular Ca2+ stores and activation of PKC via diacylglycerol (DAG).

Go back
574.0, 804.0
23.0, 23.0

p55

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e104 MO000016695

MO000000104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c259 : 1
stoichiometry:c165 : 1

m114*m290231*0.1

nodelay

--

true

0

false

PMID: 15081522,9763609 Following BCR-induced activation of Btk, PLCgamma becomes phosphorylated with subsequent production of IP3, mobilisation of intracellular Ca2+ stores and activation of PKC via diacylglycerol (DAG).

Go back
703.0, 753.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 MO000000023

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m67*m83*0.1

nodelay

--

true

0

false

PMID: 15081522 Btk deficient cells also show defects in JNK and p38 MAPK activation, indicating a role for Btk upstream on the pathways regulating their activation

Go back
522.0, 748.0
23.0, 23.0

p57

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 MO000000022

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m67*m85*0.1

nodelay

--

true

0

false

PMID: 15081522 Btk deficient cells also show defects in JNK and p38 MAPK activation, indicating a role for Btk upstream on the pathways regulating their activation

Go back
262.0, 692.0
23.0, 23.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e81 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m86*m5*0.1

nodelay

--

true

0

false

PMID:15081522 These and other pathways activated by Btk lead to the activation of transcription factors, principally NFKappaB, and AP-1, which are responsible for mediating the induction of genes required for B cell survival and proliferation.

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432.0, 734.0
27.0, 27.0

p6

p6

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e12

e14 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c120 : 1

m13*0.1

nodelay

--

true

0

false

PMID:15081522 This results in phosphorylation of IKappaB on serines 32 and 36, which targets it for ubiquitination and subsequent degradation.

Go back
654.0, 816.0
23.0, 23.0

p59

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 e82

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m67*m87*0.1

nodelay

--

true

0

false

PMID:15081522 These and other pathways activated by Btk lead to the activation of transcription factors, principally NFKappaB, and AP-1, which are responsible for mediating the induction of genes required for B cell survival and proliferation.

Go back
861.0, 439.0
25.0, 25.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000000102

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m367*m90*0.1

nodelay

--

true

0

false

PMID:15081522 Using its SH2 domain Btk binds the adaptor protein BLNK/SLP-65 (in B cells), which serves as a scaffold for binding PLC-gamma, Vav and Grb-2, each of which is responsible for activating individual downstream pathways

Go back
391.0, 337.0
21.0, 21.0

p61

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000000044

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m367*m73*0.1

nodelay

--

true

0

false

PMID:15081522 Using its SH2 domain Btk binds the adaptor protein BLNK/SLP-65 (in B cells), which serves as a scaffold for binding PLC-gamma, Vav and Grb-2, each of which is responsible for activating individual downstream pathways

Go back
419.0, 445.0
21.0, 21.0

p61

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000000012

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m367*m91*0.1

nodelay

--

true

0

false

PMID:15081522 Using its SH2 domain Btk binds the adaptor protein BLNK/SLP-65 (in B cells), which serves as a scaffold for binding PLC-gamma, Vav and Grb-2, each of which is responsible for activating individual downstream pathways

Go back
613.0, 371.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000001935 MO000017822

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m367*m2574*0.1

nodelay

--

true

0

false

PMID:15081522,9012831,10373551,11120822 A more direct involvement in transcriptional regulation has been suggested from the observation that Btk can interact with the transcription factors BAP135/TFII-I and Bright, and regulate their activation

Go back
117.0, 927.0
25.0, 25.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017012 MO000000088

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m1912*m95*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
810.0, 856.0
23.0, 23.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000063687 e65

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m38562*m67*0.1

nodelay

--

true

0

false

PMID:15081522 A number of proteins have been identified that bind Btk and negatively regulate its function. These include the recently identified IBtk (inhibitor of Btk), a 26 kDa protein identified in a yeast-two-hybrid screen using Btk as a bait.

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109.0, 1279.0
25.0, 25.0

p65

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000089 MO000017013

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m64*m1913*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
270.0, 472.0
23.0, 23.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e87 MO000001935

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m96*m367*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
402.0, 632.0
23.0, 23.0

p68

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 MO000001935

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m97*m367*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
277.0, 891.0
25.0, 25.0

p7

p7

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 15081522 The NFKappaB subunits are thus released and translocate into the nucleus where they bind their target promoters and initiate gene transcription

Go back
1121.0, 1247.0
25.0, 25.0

p65

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007384 MO000018458

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c256 : 1

m871*m3096*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
482.0, 792.0
23.0, 23.0

p68

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000001935 e103

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c257 : 1
stoichiometry:c205 : 1

m367*m113*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
482.0, 672.0
23.0, 23.0

p68

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000001935 e89

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c211 : 1
stoichiometry:c206 : 1

m367*m99*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
494.0, 248.0
23.0, 23.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000001935

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m3961*m367*0.1

nodelay

--

true

0

false

PMID: 15081522 Further analysis revealed that Btk interacted with the TIR domain of TLR4, the receptor for Gram negative LPS.

Go back
338.0, 1432.0
23.0, 23.0

p73

p74

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e91 MO000017705

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c16 : 1
stoichiometry:c214 : 1

m101*m2465*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
542.0, 780.0
23.0, 23.0

p68

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e92 MO000001935

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m102*m367*0.1

nodelay

--

true

0

false

PMID:15081522 Btk is also activated by receptors other than TLR4 and the BCR, including the receptors for IL-3, IL-5 and IL-6, G protein coupled receptors (GPCR) and FcepsilonRI receptors on mast cells

Go back
790.0, 912.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000017825

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m67*m2577*0.1

nodelay

--

true

0

false

PMID:15081522 Another negative regulator of Btk activity is the protein Sab, which binds the SH3 domain of Btk (constitutively) and directly inhibits kinase activity.

Go back
797.0, 971.0
25.0, 25.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000016872

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c226 : 1
stoichiometry:c228 : 1

m67*m1795*0.1

nodelay

--

true

0

false

PMID: 15081522,7629518 The SH3 domain of Btk has also been shown to interact with c-Cbl, a multi-domain-containing protein. c-Cbl may also function to negatively regulate Btk activity in cells

Go back
675.0, 389.0
22.0, 22.0

p64

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e97 MO000001935

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m107*m367*0.1

nodelay

--

true

0

false

PMID:15081522,9012831,10373551,11120822 A more direct involvement in transcriptional regulation has been suggested from the observation that Btk can interact with the transcription factors BAP135/TFII-I and Bright, and regulate their activation

Go back
760.0, 582.0
27.0, 27.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 MO000000248

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m67*m207*0.1

nodelay

--

true

0

false

PMID:15081522,10811867 BCR stimulation also failed to activate IKappaB kinase (IKK) in these cells, suggesting that Btk is required for activation of IKK downstream of the BCR

Go back
394.0, 16.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022131 MO000018132 MO000019394

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m6438*m2828*m3961*0.1

nodelay

--

true

0

false

PMID: 15081522 The discovery that TLR4 was the long sought after signalling component of the lipopolysaccharide (LPS) receptor complex (composed of CD14 and MD2 on myeloid cells) has resulted in intense research into how signalling pathways are regulated downstream of TLR4

Go back
283.0, 241.0
21.0, 21.0

p17

p80

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e26

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m32*m28*0.1

nodelay

--

true

0

false

PMID: 15081522 PI3K is activated by multiple TLR members, most notably TLR2, TLR4 and TLR9, resulting in increased PIP3 production.

Go back
319.0, 493.0
21.0, 21.0

p17

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e26

MO000000030

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m40*m28*0.1

nodelay

--

true

0

false

PMID: 15081522 PI3K is activated by multiple TLR members, most notably TLR2, TLR4 and TLR9, resulting in increased PIP3 production.

Go back
274.0, 580.0
23.0, 23.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000001935 MO000042007

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m367*m19823*0.1

nodelay

--

true

0

false

PMID:15081522,12724322 In confirmation of a putative role for Btk downstream of TLRs, we have identified the TIR domain of TLR8 as a Btk interactor in a yeast-two-hybrid screen

Go back
510.0, 172.0
23.0, 23.0

p83

p83

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 MO000016573

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c35 : 1

m18*m1572*0.1

nodelay

--

true

0

false

PMID: 15081522 Specifically, MyD88 has been shown to become tyrosine phosphorylated after LPS stimulation, which stimulates an interaction between the newly phosphorlyated tyrosine on MyD88 and the SH2 domain of p85 PI3K and MyD88.

Go back
838.0, 196.0
23.0, 23.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000001935 MO000066028

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m367*m40889*0.1

nodelay

--

true

0

false

PMID: 15081522 Using its SH2 domain Btk binds the adaptor protein BLNK/SLP-65 (in B cells), which serves as a scaffold for binding PLC-gamma, Vav and Grb-2, each of which is responsible for activating individual downstream pathways.

Go back
762.0, 336.0
23.0, 23.0

p84

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000012 MO000066028 MO000000044 MO000000102

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c254 : 1
stoichiometry:c255 : 1

m91*m40889*m73*m90*0.1

nodelay

--

true

0

false

PMID: 15081522 Using its SH2 domain Btk binds the adaptor protein BLNK/SLP-65 (in B cells), which serves as a scaffold for binding PLC-gamma, Vav and Grb-2, each of which is responsible for activating individual downstream pathways.

Go back
534.0, 16.0
23.0, 23.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016882

e17 MO000018132 MO000022131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m17*m155666*0.1

nodelay

--

true

0

false

PMID: 15081522 The discovery that TLR4 was the long sought after signalling component of the lipopolysaccharide (LPS) receptor complex (composed of CD14 and MD2 on myeloid cells) has resulted in intense research into how signalling pathways are regulated downstream of TLR4

Go back
440.0, 582.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.1845016638977, 706.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 1120.11894595825

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 1121.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 137.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.4630710245168, 928.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.8212516732967, 935.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 137.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 847.0229595244464

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0, 833.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.5460916657664, 848.9813397304325

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.0, 1202.5242268444122

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.8952103383059, 637.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 1138.8861147993366

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 137.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
146.0, 1024.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.8676255087126, 1007.4492994358155

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 1016.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1123.3074649768096, 672.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.0, 685.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 736.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1068.077694233019, 828.7291077141713

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.0, 898.6148844628539

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.2855322440993, 669.9949028347804

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.0, 748.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 536.8371905383993

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.7662784260191, 543.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.0, 688.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.84834572210286, 686.36345376026

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
150.0, 671.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 644.5719500300767

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
308.473747089435, 586.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 643.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.6564023547028, 653.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.3609224517816, 134.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.7829814889137, 217.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.0, 294.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.40905094349677, 1241.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 234.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.0, 137.60450800935604

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 250.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.759841579916, 120.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 210.14967818848416

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 316.5538553641523

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.97643588401263, 677.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0075819419861, 439.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 521.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.4906334205524, 549.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 586.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.864616207626, 122.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
353.0, 246.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.07841912241383, 295.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0678733031674, 129.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.0, 233.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 323.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 696.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.7252934123487, 137.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.0, 329.4854338271991

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 323.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.7730671117325, 536.420111396767

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.4906334205524, 609.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.0, 641.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.5685159055888, 660.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 709.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
904.0, 763.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.8311367793272, 1110.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.14296999000135, 1376.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.223472969005, 1178.7942826023123

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.8511667745413, 1172.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.9614000012783, 697.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 537.9967366916856

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.5978308147678, 544.5242268444122

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
505.56931187962687, 820.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.1923903908059, 610.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.0, 670.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.1219853038187, 771.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.6526325281276, 608.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
338.6768752524938, 757.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.5572042599299, 665.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.97469620148183, 767.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.1871368396817, 718.0714236390834

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
291.1938480016686, 592.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 715.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.8870281397044, 611.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.727584412026, 795.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.9032775043543, 839.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 258.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.0, 471.95166299178715

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.9711254108328, 846.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.9267498715262, 464.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.13893091161117, 255.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 247.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.9269205859564, 319.00222078299703

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0714236390834, 262.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 457.4437601569802

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 463.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 262.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.769862720718, 360.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.7053735814004, 396.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.0, 916.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
131.5909734841225, 846.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.7734525962109, 882.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
142.0, 941.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.30428196236983, 1209.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.0, 1292.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 502.9033006417404

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.41835371484297, 258.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 495.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
217.0, 662.6327567804934

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.00657076399744, 655.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0, 542.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 34.745543623388315

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.388444033389, 262.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0613012044826, 1217.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 1273.4626882951532

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 834.8139547453751

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.49757820902, 262.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.765824498571, 812.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.99171555893554, 695.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 130.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.89564944152806, 262.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.9328032894898, 250.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.73527602328033, 45.44803543595617

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.02855245727176, 131.2589500159179

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.5759766439265, 702.8432326000061

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.9914928787895, 1441.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.01837509850816, 1385.4087388781563

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 810.3631454829965

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.2339891739679, 798.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.6770983839624, 262.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 876.0110163756475

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.1893855808102, 619.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 47.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 875.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.2993549472981, 663.7830776784164

c221

c221

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
815.8555588877422, 620.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 935.2719439311038

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 932.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0880120792216, 663.8491855911956

c225

c225

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
762.0, 1001.488102949512

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.2208305756426, 620.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 994.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.8834429275263, 663.9012214233242

c229

c229

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
417.0, 33.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 417.1676940130167

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 262.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 411.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.995807196266, 596.2589735124296

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
707.0, 597.8999121222475

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.8082881023973, 605.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.0, 258.8244580194739

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
311.4419846905368, 177.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 175.3096029358855

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 521.8472817673643

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.488312483317, 46.60317703235751

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.59625805875584, 185.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
340.0, 186.78540345064516

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.3906279097154, 262.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 573.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.30510305950008, 597.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.3150904377225, 121.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.9895013078127, 185.40971801578527

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 233.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 211.26942476307005

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.9952479948287, 208.27569820671823

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.906973581205, 31.21645747403153

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 211.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 353.1359046396533

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
791.7680961519318, 220.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 236.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.102502099981, 366.71877483280707

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.0, 352.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1065.8807741667297, 1248.3760081878418

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.2515858903128, 817.9917605968277

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.6564023547028, 720.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.3452017110776, 764.0

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
557.0, 36.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.2141339463039, 39.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.9382230137093, 30.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 252.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 591.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.9112181802222, 303.18853982050285

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 311.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.0, 423.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 433.5838051064926

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.740986951436, 185.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 188.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 242.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.440889495341, 262.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 377.5381044187371

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 386.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0821643129632, 462.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.5865908166026, 262.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.6136689420844, 811.456022239382

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.80898753270714, 302.49063342055234

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.0, 470.00201329192197

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 470.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 282.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 366.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.7125827131566, 126.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 185.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 178.19268783710348

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.5559743736493, 500.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.3701422443754, 185.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.0, 313.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 127.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.0, 171.1215563631061

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.0, 133.15308596626224

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.0, 136.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.7029180288541, 217.52955736609366

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 125.64380241585256

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
163.77846408158624, 232.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 200.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.9424971120452, 459.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
158.0, 281.9922778767137

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
161.60583871585183, 357.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.43108350559987, 341.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 383.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
181.9236771698309, 446.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.47953697234416, 435.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 476.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 522.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.99065116865603, 581.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.6465269501284, 595.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 547.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.0, 512.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.0, 417.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 519.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.0, 944.2558262477422

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
494.0, 939.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.3332047511127, 597.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.4610074998332, 973.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
432.7436835838358, 119.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.0, 187.1723892887157

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.23337817661377, 121.41734402044744

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 617.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.33774828479216, 330.6508125684107

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 131.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.40624199493405, 177.62954778881527

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
223.0, 165.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
371.0, 408.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 432.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 170.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.05458406215325, 554.2289589627687

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.6198709158227, 551.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0, 137.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
626.9040962700088, 678.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1059.0, 881.8374782761443

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 816.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 989.7449505064465

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 137.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.0, 967.8245998661823

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 1053.4112203592688

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 1053.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 137.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
609.0, 1188.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.0, 1189.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back