1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15199958.csml convertedTime:2009.07.02.15:35

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title A Toll-like receptor in horseshoe crabs.
Authors Inamori K, Ariki S, Kawabata S.
Affiliation Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan.
Abstract Non-self-recognition of invading microbes relies on the pattern-recognition ofpathogen-associated molecular patterns (PAMPs) derived from microbial cell-wallcomponents. Insects and mammals conserve a signaling pathway of the innateimmune system through cell-surface receptors called Tolls and Toll-likereceptors (TLRs). Bacterial lipopolysaccharides (LPSs) are an important triggerof the horseshoe crab's innate immunity to infectious microorganisms. Horseshoecrabs' granular hemocytes respond specifically to LPS stimulation, inducing thesecretion of various defense molecules from the granular hemocytes. Here, weshow a cDNA which we named tToll, coding for a TLR identified from hemocytes ofthe horseshoe crab Tachypleus tridentatus. tToll is most closely related toDrosophila Toll in both domain architecture and overall length. Human TLRs havebeen suggested to contain numerous PAMP-binding insertions located in theleucine-rich repeats (LRRs) of their ectodomains. However, the LRRs of tTollcontained no obvious PAMP-binding insertions. Furthermore, tToll wasnon-specifically expressed in horseshoe crab tissues. These observations suggestthat tToll does not function as an LPS receptor on granular hemocytes.
PMID 15199958
Model Abstract

Entity

MO000016882:LPS MO000019394:TLR4 MO000022131:MD-2 MO000042012:TLR9 e1: e10: e11:gastrulation defective e12:easter e13:snake e14:spaetzle{cleaved} e15:dToll:spaetzle e16:persephone e17:LE e18:peptidoglycan e19:peptidoglycan:LE e2: e20:prophenoloxidase e21:phenoloxidase e22:Beta 1,3 glucan e23:Factor c{active} e24:Factor G e25:Factor c e26:Factor G{active} e27:factor B e28:factor B{active} e29:clotting enzyme e3: e30:proclotting enzyme e31:coagulogen e32:coagulogen gel e33:hemocyanin e34:TLR4:MD-2 e35:TLR4:MD-2:LPS e36:CpG DNA e37:TLR9:CpGDNA e4: e5:spaetzle e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:dToll e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p2 p3 p4 p5 p6 p7 p9
Model Detail
1085.0, 421.0
29.0, 29.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p18

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1008.0, 664.0
24.0, 24.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1087.0, 599.0
26.0, 26.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1004.0, 744.0
24.0, 24.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
164.77189870210006, 153.61090730521164
888.7401087025158, 1290.4506378360509

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
171.27220402660484, 186.12735142326449
849.5239648305443, 1195.04134548587

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
384.0, 385.0
16.405051449953223, 37.85781103835359

gastrulation defective

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
444.0, 273.0
16.478016838166507, 38.02619270346118

easter

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
332.0, 265.0
16.514499532273156, 38.110383536014965

snake

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
239.0, 61.5
33.749245320990134, 20.81203461461059

spaetzle{cleaved}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p1 p2 p3 p5

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
187.5, 235.0
25.909230431922822, 50.146897610173205

dToll:spaetzle

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
271.0, 311.0
18.16838166510757, 41.9270346117867

persephone

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
566.5, 164.0
26.045694200351495, 40.07029876977154

LE

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
549.0, 81.0
53.767872161480234, 30.468460891505458

peptidoglycan

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
672.5, 161.0
23.367244025433017, 45.22692392019293

peptidoglycan:LE

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
164.77189870210006, 153.61090730521164
888.7401087025158, 1290.4506378360509

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
594.0, 321.5
27.520000000000007, 20.64

prophenoloxidase

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
715.24, 458.18
25.280000000000005, 18.96

phenoloxidase

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7 p14

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
986.0, 91.0
60.0, 34.0

Beta 1,3 glucan

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
858.5, 528.0
19.710002012477364, 31.96216542563896

Factor c{active}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p18

p10

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
814.5, 249.0
18.503723083115318, 30.00603743207889

Factor G

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
926.5, 532.0
19.710002012477364, 31.96216542563896

Factor c

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
906.5, 329.0
18.503723083115318, 30.00603743207889

Factor G{active}

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
741.0, 610.5
29.378144495874412, 18.116522439122562

factor B

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
613.0, 540.5
37.57697725900583, 23.17246930972027

factor B{active}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
390.0, 538.5
35.51999999999999, 26.639999999999997

clotting enzyme

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11 p13

p12

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
182.54670087615037, 171.38570947926198
853.1905043544153, 1254.9010334879515

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
522.0, 618.5
35.51999999999999, 26.639999999999997

proclotting enzyme

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p13 p14

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
324.0, 681.0
16.441534144059865, 37.942001870907376

coagulogen

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
452.0, 685.0
16.441534144059865, 37.942001870907376

coagulogen gel

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
685.5, 651.0
21.33326625075468, 34.59448581203461

hemocyanin

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1004.5, 593.0
31.330278286952172, 38.363606065655716

TLR4:MD-2

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1009.5, 503.0
21.831177373383028, 42.25389169041877

TLR4:MD-2:LPS

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1086.0, 764.0
60.0, 16.0

CpG DNA

--

e36

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1008.5, 835.0
22.01468976101732, 42.60907695680772

TLR9:CpGDNA

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
215.4300848981436, 202.4916132838498
787.4237363104291, 1192.6892258787746

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
347.0, 69.5
33.749245320990134, 20.81203461461059

spaetzle

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p2 p3 p5

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
321.8972948580412, 768.8122354476636
483.3136776396829, 438.31240411643535

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
374.09877214500875, 779.1996022192153
282.60799772599717, 424.81202205946096

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
328.1974731512961, 774.6624010056859
470.71332105317407, 426.61207300039064

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
329.0974986217608, 775.5624264761504
468.91327011224377, 424.81202205946096

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
321.8972948580412, 768.8122354476636
483.3136776396829, 438.31240411643535

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
321.8972948580412, 768.8122354476636
483.3136776396829, 438.31240411643535

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
329.0974986217608, 775.5624264761504
468.91327011224377, 424.81202205946096

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
674.7072792803051, 948.8173295406559
30.194783009956645, 27.334224619539743

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
595.5050378793889, 1074.8208954057502
85.50241969417112, 77.40219045998661

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
321.8972948580412, 768.8122354476636
483.3136776396829, 438.31240411643535

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
227.5, 165.0
24.514938488576433, 37.7152899824253

dToll

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
435.81160925883216, 963.5946460317955
15.305834015996883, 7.369475637331839

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
435.30050413662616, 941.6171257769354
52.388275026120716, 94.29889504701728

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
457.2780243914872, 1002.9497404416625
8.177681955296885, 8.17768195529689

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
176.4486474290206, 158.80378268611847
871.5771608377985, 1235.0023238439655

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
179.5624470895328, 180.60038030970344
836.1143559050087, 1214.038044774072

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
187.8659128508984, 202.39697793328835
832.2970352328211, 1198.1162400272697

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
325.0, 121.0
22.0, 22.0

p1

p1

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e13 e5

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c7 : 1

m13*m5*0.1

nodelay

--

true

0

false

PMID: 15199958,8808632 In the embryo, a proteolytic cascade that includes three proteases (gastrulation defective, snake, and easter) cleaves a cytokine-like protein, Spaetzle, as a ligand for dToll

Go back
744.0, 536.0
23.0, 23.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e23

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m27*m23*0.1

nodelay

--

true

0

false

PMID: 15199958 The activated factor C activates factor B, which converts the proclotting enzyme into the clotting enzyme, which in turn converts coagulogen into an insoluble coagulin gel

Go back
503.0, 539.0
25.0, 25.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m28*m30*0.1

nodelay

--

true

0

false

PMID: 15199958 The activated factor C activates factor B, which converts the proclotting enzyme into the clotting enzyme, which in turn converts coagulogen into an insoluble coagulin gel

Go back
353.0, 613.0
21.0, 21.0

p12

p12

cso30:i:ME_UnknownProcess

cso30:i:CC_Cytosol

--

e29 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m29*m31*0.1

nodelay

--

true

0

false

PMID: 15199958 The activated factor C activates factor B, which converts the proclotting enzyme into the clotting enzyme, which in turn converts coagulogen into an insoluble coagulin gel

Go back
616.0, 432.0
23.0, 23.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m26*m30*0.1

nodelay

--

true

0

false

PMID: 15199958 The activated factor G activates the proclotting enzyme directly

Go back
596.0, 656.0
24.0, 24.0

p14

p14

cso30:i:ME_UnknownInteraction

cso30:i:CC_Cytosol

--

e30 e33

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m30*m33*0.1

nodelay

--

true

0

false

PMID: 15199958 The horseshoe crab coagulation cascade promotes prophenoloxidase activation through the non-enzymatic interaction of factor B or through the interaction of proclotting enzyme with hemocyanin.

Go back
1089.0, 665.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c51 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 15199958,10359581 TLR-4 forms a complex with an accessory protein MD-2, and it triggers the innate immune response to LPS

Go back
1089.0, 513.0
21.0, 21.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 MO000016882

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m34*m155666*0.1

nodelay

--

true

0

false

PMID: 15199958,10359581 TLR-4 forms a complex with an accessory protein MD-2, and it triggers the innate immune response to LPS

Go back
1076.0, 824.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m19828*m36*0.1

nodelay

--

true

0

false

PMID: 15199958,11130078 Furthermore, in TLR-9, which is essential for recognizing and triggering the inflammatory response to bacterial DNA containing CpG sequences, long inserts are present in repeat-2, repeat-5, and repeat-8 after position 10

Go back
924.0, 424.0
23.0, 23.0

p18

p18

cso30:i:ME_Autocleavage

cso30:i:CC_Cytosol

--

MO000016882 e25

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m155666*m25*0.1

nodelay

--

true

0

false

PMID: 15199958,3512266 These serine protease zymogens are autocatalytically activated by LPS and b-1,3-glucans, respectively.

Go back
377.0, 125.0
22.0, 22.0

p1

p2

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e11 e5

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c3 : 1
stoichiometry:c8 : 1

m11*m5*0.1

nodelay

--

true

0

false

PMID: 15199958,8808632 In the embryo, a proteolytic cascade that includes three proteases (gastrulation defective, snake, and easter) cleaves a cytokine-like protein, Spaetzle, as a ligand for dToll

Go back
437.0, 121.0
22.0, 22.0

p1

p3

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e12 e5

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c4 : 1
stoichiometry:c9 : 1

m12*m5*0.1

nodelay

--

true

0

false

PMID: 15199958,8808632 In the embryo, a proteolytic cascade that includes three proteases (gastrulation defective, snake, and easter) cleaves a cytokine-like protein, Spaetzle, as a ligand for dToll

Go back
148.0, 96.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e6

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m6*0.1

nodelay

--

true

0

false

PMID: 15199958,8808632 In the embryo, a proteolytic cascade that includes three proteases (gastrulation defective, snake, and easter) cleaves a cytokine-like protein, Spaetzle, as a ligand for dToll

Go back
268.0, 120.0
23.0, 23.0

p5

p5

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

e5 e16

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m5*m16*0.1

nodelay

--

true

0

false

PMID: 15199958,1209870,11812988 During infection, the cleaved form of Spaetzle is produced through another proteolytic cascade, one that includes Persephone, a newly identified serine protease.

Go back
653.0, 105.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 15199958,12359879 Overexpression of peptidoglycan-recognition protein-LE, a receptor for the diaminopimelic acid-type peptidoglycan, leads to the activation of prophenoloxidase cascade in Drosophila larvae

Go back
676.0, 276.0
23.0, 23.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e19 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 15199958,12359879 Overexpression of peptidoglycan-recognition protein-LE, a receptor for the diaminopimelic acid-type peptidoglycan, leads to the activation of prophenoloxidase cascade in Drosophila larvae

Go back
904.0, 252.0
23.0, 23.0

p8

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m22*m24*0.1

nodelay

--

true

0

false

PMID: 15199958,7822328 These serine protease zymogens are autocatalytically activated by LPS and b-1,3-glucans, respectively.

Go back
336.19666186209093, 150.99758239169807

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.4724146788087, 78.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
176.80762147124662, 123.50195718328627

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
163.0, 119.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.7839864320407, 90.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 151.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
262.9373322778884, 89.44124177065058

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.0, 102.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 130.0602765668994

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 126.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 206.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.66914335816205, 90.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 298.88514344942905

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 299.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.3018747130427, 125.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
833.0, 264.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 275.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.0, 567.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.9958409147176, 548.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 90.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.9924492668405, 544.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 552.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.2346363266411, 571.6815623728286

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 552.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.1369251194047, 565.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 641.3612370850286

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 632.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.5578746557937, 347.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 462.24154889955076

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.1854160649823, 450.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
381.0, 90.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 641.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 668.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 483.84979313133704

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.0, 676.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 625.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 539.9415075534005

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 450.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 524.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 768.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.1714881303978, 780.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.1344347962285, 154.9988703755945

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.6857134627292, 840.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1042.2699670121, 629.9686531039283

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 436.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.0, 455.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.2625061574892, 447.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.1845662462981, 150.99787067291834

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.35814251141386, 86.85530882689784

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.182830471947, 83.52234955835864

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.62584510159456, 79.41795088587143

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back