_enti_e8
_enti_e9
_enti_e1
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e59
_enti_e53
_enti_e50
_enti_e56
_enti_e52
_enti_e51
_enti_e54
_enti_e61
_enti_e57
_enti_e58
_enti_e62
_enti_e60
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c1 cso30:c:InputProcess connector
c149 cso30:c:InputAssociation connector
c2 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c3 cso30:c:InputProcess connector
c250 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c5 cso30:c:InputProcess connector
c249 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c7 cso30:c:InputProcess connector
c247 cso30:c:InputAssociation connector
c8 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c9 cso30:c:InputProcess connector
c248 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c11 cso30:c:InputProcess connector
c251 cso30:c:InputAssociation connector
c12 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c13 cso30:c:InputProcess connector
c252 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 15346645
IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.
c15 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 15346645
IKK is an heterodimer IKKa/IKKb associated with either dimer or trimer of IKKg.
c17 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c28 cso30:c:InputProcess connector
c29 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c30 cso30:c:InputProcess connector
c31 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c35 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c45 cso30:c:InputProcess connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c50 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex.
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c55 cso30:c:InputProcess connector
c57 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p25_propro_p25
c58 cso30:c:InputProcess connector
c60 cso30:c:InputAssociation connector
c59 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c61 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c64 cso30:c:InputProcess connector
c66 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c67 cso30:c:InputProcess connector
c69 cso30:c:InputAssociation connector
c68 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c70 cso30:c:InputProcess connector
c72 cso30:c:InputAssociation connector
c71 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 15346645
Activated IKK-kinases induce both phosphorylation of the catalytic subunits and activation of the IKK complex, which in turn phosphorylates IkB.
PMID: 15346645
Upon activation, IkB is rapidly phosphorylated on two serine residues (ser-32 and ser-36 in IkBa, ser-19 and ser-23 in IkBb).
c73 cso30:c:InputProcess connector
c75 cso30:c:InputAssociation connector
c74 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 15346645
This leads to IkB ubiquitination and subsequent degradation by the 26S proteasome.
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL)immunoreceptors.
PMID: 15346645, 12586748
oxLDL-mediated NF-kB nuclear translocation.
c81 cso30:c:InputProcess connector
c168 cso30:c:InputAssociation connector
c82 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c83 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c86 cso30:c:InputAssociation connector
c87 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c88 cso30:c:InputProcess connector
c89 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c92 cso30:c:InputAssociation connector
c91 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c93 cso30:c:InputProcess connector
c94 cso30:c:InputProcess connector
c95 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c96 cso30:c:InputAssociation connector
c97 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
PMID: 15346645, 11557664
This effect is mediated by oxidative stress and PKC as assessed bythe inhibition of NF-kB DNA binding and transcriptionof VCAM-1 gene by the antioxidant NAC and calphostin C.
c98 cso30:c:InputProcess connector
c99 cso30:c:InputProcess connector
c145 cso30:c:InputInhibitor connector
c146 cso30:c:InputInhibitor connector
c100 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c101 cso30:c:InputAssociation connector
c144 cso30:c:InputAssociation connector
c147 cso30:c:InputInhibitor connector
c148 cso30:c:InputInhibitor connector
c102 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c103 cso30:c:InputProcess connector
c104 cso30:c:InputProcess connector
c105 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c106 cso30:c:InputAssociation connector
c107 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c108 cso30:c:InputProcess connector
c110 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c111 cso30:c:InputAssociation connector
c112 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c114 cso30:c:InputProcess connector
c115 cso30:c:InputProcess connector
c113 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 15346645, 11499717, 11795276
The released NF-kB dimer then translocates to the nucleus where it binds to specific promoters and activates the transcriptionof a wide variety of target genes including genes of cytokines (IL-1, TNF-a) adhesion molecules (VCAM-1, ICAM-1, E-selectin), regulators of apoptosis (c-IAPs, Bcl-xL) immunoreceptors.
c116 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 15346645
A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB.
The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
c118 cso30:c:InputAssociation connector
c119 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 15346645
A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB.
The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
c120 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 15346645
A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB.
The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 15346645
A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB.
The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 15346645
A second mechanism of autoregulation of the NF-kB/IkB system is also induced by NF-kB itself which elicits the synthesis of its own inhibitor IkB.
The newly synthetized IkBa proteins enter the nucleus to bind activated NF-kB and carry it to the cytoplasm,thereby terminating the activation of gene expression.
c127 cso30:c:InputProcess connector
c128 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 15346645
UV radiation-induced NF-kB activation does not involve IkBa phosphorylation
c129 cso30:c:InputProcess connector
c131 cso30:c:InputAssociation connector
c130 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 15346645, 10488062, 10373503, 10723801
phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.
c132 cso30:c:InputProcess connector
c133 cso30:c:InputProcess connector
c134 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 15346645, 10488062, 10373503, 10723801
phosphorylation of IkBa at tyrosine 42, that may bind the SH2 domain ofPI3-kinase which pulls it away from NF-kB.
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
c137 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 15346645
NF-kB is a redox-sensitive transcription factorwhich is activated by intracellular reactive oxygen species (ROS), such as H2O2.
c138 cso30:c:InputProcess connector
c140 cso30:c:InputAssociation connector
c139 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 15346645, 11557664
13-HPODE (13-hydroperoxyoctadecadienoic acid) induces NF-kB activation and subsequent overexpression of the vascular cell adhesion molecule-1 (VCAM-1) in porcine vascular SMCs.
c141 cso30:c:InputProcess connector
c143 cso30:c:InputAssociation connector
c142 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c150 cso30:c:InputProcess connector
c152 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c154 cso30:c:InputAssociation connector
c153 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c156 cso30:c:InputAssociation connector
c155 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c158 cso30:c:InputAssociation connector
c157 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 15346645, 9555862, 1381720, 8622597, 9084506
Lysophosphatidylcholine (Lyso-PC) elicited PKC and tyrosine kinases activation and subsequent
NF-kB activation and overexpression of ICAM-1, VCAM-1 and MCP-1.
c159 cso30:c:InputProcess connector
c161 cso30:c:InputAssociation connector
c160 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 15346645
Low HNE concentration induces MAPK activation.
c162 cso30:c:InputProcess connector
c164 cso30:c:InputAssociation connector
c163 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 15346645, 8876974
Moderate concentrations of oxidized LDLs trigger a rapid and dose-dependent activation of NF-kB.
PMID: 15346645
ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
c165 cso30:c:InputProcess connector
c167 cso30:c:InputAssociation connector
c166 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 15346645, 8657285
Another survival mechanism that regulates cell death and proliferation induced by oxidized LDLs is the generation of bioactive sphingolipid metabolites,
for instance sphingosine-1-phosphate (S1-P).
c169 cso30:c:InputAssociation connector
c170 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 15346645, 10567432, 9826677
S1-P is involved in NF-kB activation mediated by inflammatory cytokines
c171 cso30:c:InputProcess connector
c173 cso30:c:InputAssociation connector
c172 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 15346645
ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
c174 cso30:c:InputProcess connector
c175 cso30:c:InputProcess connector
c176 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 15346645
ROS are generated by a DPI-sensitive oxidase system activated through signaling triggered by binding ofoxidized LDLs to LOX-1 (lectin-like ox-LDL receptor-1) in endothelial cells.
c177 cso30:c:InputAssociation connector
c178 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995
oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
c179 cso30:c:InputProcess connector
c180 cso30:c:InputProcess connector
c181 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995
oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
PMID: 15346645, 9888865
oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB
activation and TF expression induced by LPS.
c182 cso30:c:InputProcess connector
c184 cso30:c:InputAssociation connector
c188 cso30:c:InputInhibitor connector
c240 cso30:c:InputInhibitor connector
c183 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995
oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
c185 cso30:c:InputAssociation connector
c187 cso30:c:InputAssociation connector
c189 cso30:c:InputInhibitor connector
c186 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995
oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
c191 cso30:c:InputAssociation connector
c192 cso30:c:InputAssociation connector
c193 cso30:c:InputInhibitor connector
c190 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 15346645, 9351352, 7583531, 8690807, 11502209, 13679995
oxidized LDLs inhibit the LPS-induced NF-kB activation and subsequent expression of TNF-a,IL-1b and PAF-receptor in macrophages.
c195 cso30:c:InputAssociation connector
c196 cso30:c:InputAssociation connector
c197 cso30:c:InputInhibitor connector
c194 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 15346645, 9882624
phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in
human T-lymphocytes.
c198 cso30:c:InputProcess connector
c200 cso30:c:InputAssociation connector
c201 cso30:c:InputInhibitor connector
c199 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 15346645, 9882624
phytohaemagglutinin (PHA)-induced NF-kB activation and subsequent IL-2 receptor expression in
human T-lymphocytes.
c203 cso30:c:InputAssociation connector
c204 cso30:c:InputAssociation connector
c205 cso30:c:InputInhibitor connector
c202 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 15346645, 10206970
HNE prevents the LPS-induced IkBa phosphorylation in THP-1 monocytic cells.
c206 cso30:c:InputProcess connector
c208 cso30:c:InputAssociation connector
c209 cso30:c:InputInhibitor connector
c207 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 15346645, 10698969, 10446139
HNE (like oxidized LDLS) is also able to inhibit the proteasome activity and subsequent proteolysis of IkBa, possibly through a modification of proteasome proteins by 4-HNE.
c210 cso30:c:InputProcess connector
c212 cso30:c:InputAssociation connector
c213 cso30:c:InputInhibitor connector
c211 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 15346645, 9568715, 9422508, 12223313
Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
c214 cso30:c:InputProcess connector
c215 cso30:c:InputProcess connector
c216 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 15346645, 9568715, 9422508, 12223313
Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
c217 cso30:c:InputProcess connector
c218 cso30:c:InputProcess connector
c219 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 15346645, 9568715, 9422508, 12223313
Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
c220 cso30:c:InputProcess connector
c221 cso30:c:InputProcess connector
c222 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 15346645, 9568715, 9422508, 12223313
Oxidized PUFAs, such as 9-HODE and 13-HODE, prostaglandin J2 and HETE, have been identified as endogenous ligands and activators of PPARg.
c223 cso30:c:InputProcess connector
c224 cso30:c:InputProcess connector
c225 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 15346645, 10764682, 10085242
NF-kB may enhance the pro-apoptotic effect of oxidized LDLs by up-regulating LOX-1 expression.
c226 cso30:c:InputAssociation connector
c227 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 15346645, 10508269, 10022897, 10234031
NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
c228 cso30:c:InputAssociation connector
c229 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 15346645, 10508269, 10022897, 10234031
NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
c230 cso30:c:InputAssociation connector
c231 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 15346645, 10508269, 10022897, 10234031
NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
c232 cso30:c:InputAssociation connector
c233 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 15346645, 10508269, 10022897, 10234031
NF-kB may also up-regulate the expression of pro-apoptotic genes such as Fas ligand, Fas (Cd95), c-myc and p53,thereby sensitizing cells to apoptotic stimuli
c234 cso30:c:InputAssociation connector
c235 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 15346645, 9888865
oxidized LDLs significantly enhanced TF expression induced by LPS in human monocytes, whereas other reports have shown that lysoPC induce a decrease in both NFkB
activation and TF expression induced by LPS.
c236 cso30:c:InputAssociation connector
c238 cso30:c:InputAssociation connector
c239 cso30:c:InputInhibitor connector
c237 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 15346645, 11034947
NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
c242 cso30:c:InputAssociation connector
c241 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 15346645, 11034947
NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
c244 cso30:c:InputAssociation connector
c243 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 15346645, 11034947
NF-kB-mediated overexpression of Angiotensin Receptor-1 (AT1) which may up-regulate LOX-1 expression and enhances the toxicity of oxidized LDLs.
c246 cso30:c:InputAssociation connector
c245 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 15346645
In response to upstream stimuli, IKK-kinases are activated and recruited to the complex via IKKg.
c253 cso30:c:InputProcess connector
c255 cso30:c:InputAssociation connector
c254 cso30:c:OutputProcess connector
PKC_enti_MO000000104
PKC
PKC{active}_enti_e5
PKC{active}
NIK_enti_MO000000203
NIK
NIK{active}_enti_e6
NIK{active}
TBK1_enti_MO000019331
TBK1
TBK1_enti_e11
TBK1
MEKK1_enti_MO000000047
MEKK1
MEKK1{active}_enti_e12
MEKK1{active}
MEKK2_enti_MO000009092
MEKK2
MEKK3_enti_MO000009093
MEKK3
MEKK3{active}_enti_e13
MEKK3{active}
MEKK2_enti_e14
MEKK2
AKT_enti_MO000000048
AKT
AKT{active}_enti_e15
AKT{active}
IKK-alpha:IKK-beta_enti_MO000033291
IKK-alpha:IKK-beta
IKK-gamma_enti_MO000016599
IKK-gamma
(IKK-gamma)2_enti_e16
(IKK-gamma)2
IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e17
IKK-alpha:IKK-beta:(IKK-gamma)2
MEKK3:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e18
MEKK3:IKK-alpha:IKK-beta:(IKK-gamma)2
MEKK3:IKK-alpha:IKK-beta{p}:(IKK-gamma)2_enti_e19
P
MEKK3:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
NIK:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e20
NIK:IKK-alpha:IKK-beta:(IKK-gamma)2
NIK:IKK-alpha:IKK-beta{p}:(IKK-gamma)2_enti_e21
P
NIK:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
PKC{active}:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e22
PKC{active}:IKK-alpha:IKK-beta:(IKK-gamma)2
PKC{active}:IKK-alpha:IKK-beta{p}:(IKK-gamma)2_enti_e23
P
PKC{active}:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e24
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e25
P
MEKK1:IKK-alpha:IKK-beta:(IKK-gamma)2
AKT:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e26
AKT:IKK-alpha:IKK-beta:(IKK-gamma)2
AKT:IKKA:IKKB{p}:(IKKG)2_enti_e27
AKT:IKKA:IKKB{p}:(IKKG)2
MEKK2:IKK-alpha:IKK-beta:(IKK-gamma)2_enti_e28
MEKK2:IKK-alpha:IKK-beta:(IKK-gamma)2
Mekk2:IKK-alpha:IKK-beta{p}:(IKK-gamma)2_enti_e29
P
Mekk2:IKK-alpha:IKK-beta{p}:(IKK-gamma)2
TBK1:IKKA:IKKb{p}:(IKKG)2_enti_e30
TBK1:IKKA:IKKb{p}:(IKKG)2
TBK1:IKKA:IKKB{p}:(IKKG)2_enti_e31
P
TBK1:IKKA:IKKB{p}:(IKKG)2
NF-kappaB:I-kappaB{alpha}_enti_e32
NF-kappaB:I-kappaB{alpha}
NF-kappaB:I-kappaB{alpha}{p}_enti_e33
P
NF-kappaB:I-kappaB{alpha}{p}
NF-kappaB:I-kappaB{alpha}{p}{ub}_enti_e34
P
Ub
NF-kappaB:I-kappaB{alpha}{p}{ub}
protein remnants_enti_e35
NF-kappaB{active}_enti_e36
NF-kappaB{active}
NF-kappaB_enti_e37
NF-kappaB
TNF-alpha_enti_e38
TNF-alpha
TNF-alpha:NF-kappaB_enti_e39
TNF-alpha:NF-kappaB
TNF-alpha_enti_G010329
TNF-alpha
IL-1_enti_e40
IL-1
IL-1:NF-kappaB_enti_e41
IL-1:NF-kappaB
IL-1_enti_e42
IL-1
ICAM1_enti_e43
ICAM1
ICAM1:NFkapapB_enti_e44
ICAM1:NFkapapB
ICAM1_enti_e45
ICAM1
VCAM1_enti_e7
VCAM1
VCAM1:NF-kappaB_enti_e10
VCAM1:NF-kappaB
VCAM-1_enti_G010430
VCAM-1
Eselectin_enti_e46
Eselectin
Eselectin:NFkappaB_enti_e47
Eselectin:NFkappaB
SELE_enti_G010334
SELE
BCL-xL_enti_e48
BCL-xL
BCL-xL:NFkappaB_enti_e49
BCL-xL:NFkappaB
BCL-xL_enti_e63
BCL-xL
c-IAPs_enti_e64
c-IAPs
NF-kappaB:c-IAPs_enti_e65
NF-kappaB:c-IAPs
c-IAPs_enti_e66
c-IAPs
IkappaB-alpha_enti_MO000000233
IkappaB-alpha
IkappaB-alpha_enti_e67
IkappaB-alpha
IkappaB-alpha_enti_e68
IkappaB-alpha
NF-kappaB:I-kappaB{alpha}_enti_e69
NF-kappaB:I-kappaB{alpha}
UV_enti_e70
UV
NF-kappaB_enti_e71
NF-kappaB
PI3K_enti_MO000000030
PI3K
PI3K:NFkappaB:IkappaBalpha_enti_e72
PI3K:NFkappaB:IkappaBalpha
PI3K:IKappaBalpha_enti_e73
PI3K:IKappaBalpha
H2O2_enti_e74
H2O2
H2O2
13-HPODE_enti_e75
13-HPODE
NAC_enti_e76
NAC
calphostin C_enti_e77
calphostin C
Lyso-PC_enti_e78
Lyso-PC
MCP1_enti_G010815
MCP1
Tyrosine kinase_enti_e79
Tyrosine kinase
Tyrosine kinase {active}_enti_e80
Tyrosine kinase {active}
MAPK_enti_MO000016894
MAPK
MAPK_enti_e81
MAPK
HNE_enti_e82
HNE
oxidised LDL_enti_e83
oxidised LDL
sphingosine-1-phosphate_enti_e84
sphingosine-1-phosphate
LOX1_enti_e85
LOX1
oxidized LDL:LOX1_enti_e86
oxidized LDL:LOX1
ROS_enti_e87
ROS
ROS
LPS_enti_MO000042409
LPS
TLRs_enti_MO000019395
TLRs
LPS:TLRs_enti_e88
LPS:TLRs
IL-1beta_enti_G010389
IL-1beta
PAF-receptor_enti_e89
PAF-receptor
phtohaemagglutinin_enti_e90
phtohaemagglutinin
IL-2R_enti_e91
IL-2R
PPAR-gamma_enti_e92
PPAR-gamma
9-HODE_enti_e93
9-HODE
9-HODE:PPARG_enti_e94
9-HODE:PPARG
13-HODE_enti_e95
13-HODE
13-HODE:PPARG_enti_e96
13-HODE:PPARG
HETE_enti_e97
HETE
HETE:PPARG_enti_e98
HETE:PPARG
PDGJ2_enti_e99
PDGJ2
PDGJ2:PPARG_enti_e100
PDGJ2:PPARG
LOX1_enti_e101
LOX1
FasL_enti_e102
FasL
FASN_enti_G010462
FASN
p53_enti_G010432
p53
c-myc_enti_e103
c-myc
TF_enti_e104
TF
AT1_enti_e105
AT1
AT1_enti_e106
AT1