1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15476921.csml convertedTime:2009.07.01.10:47

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of Toll-like receptors and Nod proteins in bacterial infection.
Authors Philpott DJ, Girardin SE.
Affiliation Immunite Innee et Signalisation, Institut Pasteur, 28 rue du Dr. Roux, 75724Paris 15, France. philpott@pasteur.fr
Abstract Our understanding of innate immunity in mammals has greatly expanded followingthe discovery of the family of membrane-bound receptors, called the Toll-likereceptors (TLRs). More recently, the nucleotide-binding oligomerisation domain(Nod) molecules, Nod1 and Nod2, which are cytoplasmic surveillance proteins,have also been shown to be involved in the innate immune response. These twoclasses of detection molecules, classified as "pattern recognition receptors"(PRRs), detect microbial ligands in order to initiate a defense response tofight infectious disease. These microbial ligands or "pathogen-associatedmolecular patterns" (PAMPs), detected by TLRs and Nods are often structuralcomponents of the microorganism that are not subject to much variation. Theseinclude such factors as lipopolysaccharide (LPS) and peptidoglycan from the cellwalls of bacteria. In order to understand the role of TLRs and Nod proteins ininfectious disease in vivo it is important to define the site of interactionbetween PRRs and PAMPS. Additionally, the challenge of mice deficient in thevarious PRRs in natural infection models will help to decipher the contributionof these molecules not only in the innate immune response against pathogeninfection but also how these proteins may instruct the adaptive immune responsein order to have a tailored immune response against a particular microbe.
PMID 15476921
Model Abstract

Entity

G010453:IFN-gamma MO000000058:NF-kappaB MO000000212:TRAF6 MO000000213:IRAK [activated} MO000000220:IkappaB-alpha{p} MO000000233:IkappaB-alpha MO000016573:MyD88 MO000016665:IFNgamma MO000016882:LPS MO000017265:IL-12 MO000017793:Lp MO000017949:RIP2 MO000018132:CD14 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019420:LBP MO000020434:Nod1 MO000020461:Nod2 MO000021891:Hsp MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022185:flagellin MO000022224:dsRNA MO000033676:IL-12R MO000041446:dsRNA:TLR3 MO000042032:PGN MO000042359:Nod e1: e10: e11:LTA e12:lipoarabinomannan e13:PGN: TLR2 e14:Lp: TLR2 e15:lipoarabinomannan: TLR2 e16:LTA: TLR2 e17:zymosan e18:zymosan: TLR2 e19:LPG e2: e20:LPG: TLR2 e21:flagellin: TLR5 e22:HSP: TLR4 e23:DEFB e24:DEFB: TLR4 e25:LPS: CD14: MD-2: TLR4: MyD88 e26:IRAK e27:TRAF6: IRAK {activated} e28:IKK-alpha:IKK-beta:IKK-gamma e29:IKK-alpha:IKK-beta:IKK-gamma {activated} e3: e30:IkappaB-alpha {ub} e31:protein remnants e32:NF-kappaB {nucleus} e33:GM-triDAP e34:MDP e35:GM-triDAP: Nod1 e36:MDP: Nod2 e37:Nod {oligomer} e38:RIP2: NOD {oligomer} e39:RIP2 {activated}: NOD {oligomer} e4: e40:RIP2 {activated}: NOD {oligomer}: IKK-alpha:IKK-beta:IKK-gamma (n) e41:RIP2 {activated}: NOD {oligomer}: IKK-alpha:IKK-beta:IKK-gamma e42:Ptx3 e43:C1Q e44:Ptx3: C1q e45:IL-12: IL-12R e46:S. flexneri e47:pro-inflammatory response genes e5:MD-2: TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS: CD14: MD-2: TLR4 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p4 p5 p6 p7 p8 p9
Model Detail
772.0, 1046.0
31.0, 31.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
589.0, 575.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
529.0, 183.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
448.0, 178.0
32.0, 32.0

IRAK [activated}

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
668.0, 358.0
32.0, 32.0

IkappaB-alpha{p}

--

MO000000220

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m190

10

false

infinite

0

unit false false false
TRANSPATHMO000000220

--

Go back
510.0, 356.0
36.0, 36.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p30

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
296.0, 286.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
894.0, 1104.0
36.0, 36.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
118.0, 76.0
27.0, 27.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1113.0, 959.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
98.0, 732.0
28.0, 28.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
760.0, 370.0
32.0, 32.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
167.0, 229.0
33.5, 33.5

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
231.0, 393.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p13 p14

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
224.0, 674.0
32.0, 32.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p7 p8 p9 p10

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
229.0, 1119.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
229.0, 1243.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
172.0, 122.0
31.5, 31.5

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
691.0, 201.0
34.0, 34.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
948.0, 206.0
31.0, 31.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
140.0, 366.0
32.0, 32.0

Hsp

--

MO000021891

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m6220

10

false

infinite

0

unit false false false
TRANSPATHMO000021891

--

Go back
165.0, 167.0
30.0, 30.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
164.0, 282.0
31.0, 31.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p4

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
285.0, 407.0
30.0, 30.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
154.0, 1248.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
151.0, 1109.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1023.0, 1069.0
34.0, 34.0

IL-12R

--

MO000033676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m12340

10

false

infinite

0

unit false false false
TRANSPATHMO000033676

--

Go back
231.0, 1189.0
34.0, 34.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
156.0, 630.0
24.0, 24.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
888.0, 322.0
24.0, 24.0

Nod

--

MO000042359

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m20159

10

false

infinite

0

unit false false false
TRANSPATHMO000042359

--

Go back
211.75, 121.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
229.0, 141.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
148.5, 591.25
38.18755256518082, 21.639613120269132

LTA

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
135.5, 790.25
40.13036164844407, 22.74053826745164

lipoarabinomannan

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
224.625, 622.5
31.09960839860024, 38.08115314114314

PGN: TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
219.625, 726.5
32.34073487752042, 39.600899850024994

Lp: TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
225.625, 823.5
36.75, 45.0

lipoarabinomannan: TLR2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
224.625, 530.5
31.058781869688385, 38.03116147308781

LTA: TLR2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
149.5, 878.375
36.91564147627416, 23.99516695957821

zymosan

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
229.625, 927.5
36.75, 45.0

zymosan: TLR2

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
145.5, 993.25
45.0, 25.5

LPG

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
211.75, 121.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
225.625, 1051.5
36.75, 45.0

LPG: TLR2

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
220.375, 1295.5
23.25, 45.0

flagellin: TLR5

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
229.625, 423.5
36.75, 45.0

HSP: TLR4

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
134.0, 536.0
36.0, 36.0

DEFB

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000061796

--

Go back
232.625, 482.5
31.050616563906022, 38.02116313947675

DEFB: TLR4

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
258.875, 111.5
50.155487245366125, 69.9844008074876

LPS: CD14: MD-2: TLR4: MyD88

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
356.0, 178.0
32.0, 32.0

IRAK

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
581.625, 223.5
36.75, 45.0

TRAF6: IRAK {activated}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
506.0, 296.0
44.0, 44.0

IKK-alpha:IKK-beta:IKK-gamma

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p28

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
662.0, 296.0
44.0, 44.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
228.87518862352903, 139.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
514.0, 448.0
36.0, 36.0

IkappaB-alpha {ub}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000048700

--

Go back
514.5, 581.25
34.54049396898335, 33.38914417001723

protein remnants

--

e31

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
589.0, 879.0
38.0, 38.0

NF-kappaB {nucleus}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
741.5, 61.25
45.0, 25.5

GM-triDAP

--

e33

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
877.5, 61.25
45.0, 25.5

MDP

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
745.625, 259.5
36.75, 45.0

GM-triDAP: Nod1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
881.625, 259.5
36.75, 45.0

MDP: Nod2

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
886.75, 366.5
35.328729281767956, 39.25414364640884

Nod {oligomer}

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
887.875, 427.5
32.25, 45.0

RIP2: NOD {oligomer}

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
891.875, 507.5
32.25, 45.0

RIP2 {activated}: NOD {oligomer}

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
260.5567875770579, 169.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
753.625, 635.5
36.75, 45.0

RIP2 {activated}: NOD {oligomer}: IKK-alpha:IKK-beta:IKK-gamma (n)

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
825.625, 559.5
36.75, 45.0

RIP2 {activated}: NOD {oligomer}: IKK-alpha:IKK-beta:IKK-gamma

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
931.0, 605.0
42.0, 42.0

Ptx3

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
Affymetrix108862_f_at
EnsemblENSMUSG00000027832
MGDPtx3
ProteomeHumanPSD/Ptx3
RefSeqNM_008987
TRANSFACT05664
TRANSPATHMO000039146
UnigeneMm.276776
UniProtP48759

--

Go back
883.0, 677.0
26.0, 26.0

C1Q

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000063534

--

Go back
933.625, 731.5
36.75, 45.0

Ptx3: C1q

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1013.625, 971.5
36.75, 45.0

IL-12: IL-12R

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1072.5, 453.0
31.637000568074228, 46.29804961181594

S. flexneri

--

e46

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p26

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
570.0, 1012.0
60.0, 32.0

pro-inflammatory response genes

--

e47

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
225.625, 335.5
36.75, 45.0

MD-2: TLR4

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
393.0, 839.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
443.2936761946803, 849.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
399.06992643728904, 844.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
399.93705878547314, 845.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
393.0, 839.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
393.0, 839.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
399.93705878547314, 845.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
732.9158804881849, 1012.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
656.6082338479803, 1133.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
393.0, 839.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
228.875, 215.5
38.20797394017251, 53.31345200954303

LPS: CD14: MD-2: TLR4

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
502.7511016961721, 1026.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
502.2586758712023, 1005.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
523.4329863449013, 1064.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
223.0, 127.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
226.0, 148.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
234.0, 169.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
117.0, 123.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c5 : 1
stoichiometry:c2 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 15476921 LPS binding and signalling through TLR4 involves the LPS binding protein (LBP), CD14 and MD-2.

Go back
229.0, 991.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m19*m3964*0.1

nodelay

--

true

0

false

PMID: 15476921, 12946842 More recently, the role of innate immunity in control of this infection has been investigated with the identification of TLR2 as the PRR that detects lipophosphoglycan (LPG), a glycosylphosphatidylinositol (GPI)-anchored glycolipid, and important virulence factor, from the membrane of the parasite.

Go back
153.0, 1191.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR3 detects double-stranded RNA from viruses.

Go back
153.0, 1303.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 15476921, 11489966 TLR5, which is the PRR that detects flagellin, is expressed only on the basolateral surface of intestinal epithelial cells thus requiring flagellin translocation or bacterial penetration of the epithelial barrier to induce stimulation.

Go back
141.0, 431.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m3961*m6220*0.1

nodelay

--

true

0

false

PMID: 15476921, 10623794, 11150311, 12411706 Heat-shock proteins , a number of extracellular matrix proteins and beta-defensins have been reported to stimulate TLR4 and induce pro-inflammatory signalling.

Go back
165.0, 487.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m23*m3961*0.1

nodelay

--

true

0

false

PMID: 15476921, 10623794, 11150311, 12411706 Heat-shock proteins , a number of extracellular matrix proteins and beta-defensins have been reported to stimulate TLR4 and induce pro-inflammatory signalling.

Go back
297.0, 227.0
30.0, 30.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 15476921 Upon ligand binding to the extracellular portion of these receptors, the TIR domains recruit TIR-containing adaptor molecules, including MyD88.

Go back
357.0, 227.0
30.0, 30.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m26*m25*0.1

nodelay

--

true

0

false

PMID: 15476921 This recruitment process sets up a cascade of further recruitment of adaptor molecules and activation of a number of kinases of the interleukin-1 receptor associated kinase (IRAK) family.

Go back
493.0, 231.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m184*m183*0.1

nodelay

--

true

0

false

PMID: 15476921 Activated IRAK then recruits TRAF6 that ultimately leads to the activation of the IKK complex.

Go back
585.0, 303.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m27*m28*0.1

nodelay

--

true

0

false

PMID: 15476921 Activated IRAK then recruits TRAF6 that ultimately leads to the activation of the IKK complex.

Go back
589.0, 359.0
30.0, 30.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m199*m29*0.1

nodelay

--

true

0

false

PMID: 15476921 The catalytic subunits of this complex phosphorylate I¦ÊBgreek small letter alpha, the inhibitory molecule that keeps NF-¦ÊappaB in an inactive state in the cytoplasm, and this then targets this molecule for ubiquitination and subsequent degradation by the proteasome.

Go back
109.0, 235.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c6 : 1
stoichiometry:c4 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 15476921 LPS binding and signalling through TLR4 involves the LPS binding protein (LBP), CD14 and MD-2.

Go back
593.0, 451.0
30.0, 30.0

p20

p20

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m190*0.1

nodelay

--

true

0

false

PMID: 15476921 The catalytic subunits of this complex phosphorylate I¦ÊBgreek small letter alpha, the inhibitory molecule that keeps NF-¦ÊappaB in an inactive state in the cytoplasm, and this then targets this molecule for ubiquitination and subsequent degradation by the proteasome.

Go back
593.0, 499.0
30.0, 30.0

p21

p21

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 15476921 The catalytic subunits of this complex phosphorylate I¦ÊBgreek small letter alpha, the inhibitory molecule that keeps NF-¦ÊappaB in an inactive state in the cytoplasm, and this then targets this molecule for ubiquitination and subsequent degradation by the proteasome.

Go back
593.0, 703.0
30.0, 30.0

p22

p22

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 15476921 NF-¦ÊappaB is then free to translocate to the nucleus and drive the expression of genes, many of which are involved in the pro-inflammatory response.

Go back
749.0, 203.0
30.0, 30.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c69 : 1

m34*m4923*0.1

nodelay

--

true

0

false

PMID: 15476921, 12791997 We recently demonstrated that Nod1 senses GlcNAc-MurNAc-L-Ala-¦Ã-D-Glu-meso-DAP (GM-triDAP), a naturally occurring PGN degradation product.

Go back
885.0, 207.0
30.0, 30.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c70 : 1

m35*m4947*0.1

nodelay

--

true

0

false

PMID: 15476921, 12527755, 12514169 In contrast to Nod1, Nod2 has been implicated as a general sensor for both Gram-positive and Gram-negative bacteria since biochemical and functional analyses have identified muramyl dipeptide MurNAc-L-Ala-D-isoGln (MDP), the minimal motif in all PGNs, as the essential structure recognized by Nod2. PMID: 15476921, 12527755, 12514169 Nod2 can detect the minimal structure of PGN, which is MDP.

Go back
817.0, 319.0
30.0, 30.0

p25

p25

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m20159*0.1

nodelay

--

true

0

false

PMID: 15476921 Over-expression leads to auto-oligomerization of these molecules through the NBS region.

Go back
821.0, 371.0
30.0, 30.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c97 : 1
stoichiometry:c75 : 1

m38*m2684*m47*0.1

nodelay

--

true

0

false

PMID: 15476921, 9575181, 9642260, 11423652 It is believed that this process potentially exposes the CARD domain that can then interact with the CARD domain of a serine/threonine kinase called RIP2 (also known and RICK or CARDIAK). PMID: 15476921 Biochemical analysis has revealed that RIP2 interacts with both Nod1 and Nod2 and mediates the activation of NF-¦ÊappaB by these molecules. PMID: 15476921, 11463746 Using an in vitro model of infection, we could show that infection of epithelial cells with S. flexneri is a physiological stimulus leading to recruitment and interaction of RIP2 with Nod1 leading to the subsequent activation of NF-B

Go back
821.0, 435.0
30.0, 30.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 15476921, 10880512 This recruitment process leads to the activation of RIP2 by a mechanism referred to as ¡Èinduced proximity¡É.

Go back
829.0, 515.0
30.0, 30.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c78 : 1
stoichiometry:c80 : 1

m40*m28*0.1

nodelay

--

true

0

false

PMID: 15476921, 10880512 RIP2 is likely activated following recruitment to Nod molecules allowing it to then interact with the regulatory subunit of the IKK complex, IKKgamma or NEMO.

Go back
757.0, 567.0
30.0, 30.0

p29

p29

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15476921 Again, it appears that oligomerization of IKKgamma through interactions with RIP2 induces the activation of the catalytic domains of the complex, IKKalpha and IKKbeta, leading to the phosphorylation of I¦ÊappaB-alpha, subsequent degradation of this molecule and release of NF-¦ÊappaB.

Go back
285.0, 343.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6438*m3961*0.1

nodelay

--

true

0

false

PMID: 15476921 LPS binding and signalling through TLR4 involves the LPS binding protein (LBP), CD14 and MD-2.

Go back
589.0, 399.0
30.0, 30.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m199*m41*0.1

nodelay

--

true

0

false

PMID: 15476921 Again, it appears that oligomerization of IKKgamma through interactions with RIP2 induces the activation of the catalytic domains of the complex, IKKalpha and IKKbeta, leading to the phosphorylation of I¦ÊappaB-alpha, subsequent degradation of this molecule and release of NF-¦ÊappaB.

Go back
937.0, 675.0
30.0, 30.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m43*m44*0.1

nodelay

--

true

0

false

PMID: 15476921 PTX3 participates in the complement cascade by binding to C1q and was shown to also interact with a number of microbes including A. fumigatus.

Go back
897.0, 1047.0
30.0, 30.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m93423*m46*0.1

nodelay

--

true

0

false

PMID: 15476921, 11894097, 11894098 RIP2-deficient mice have impaired production of IFN-gamma following stimulation of cells with IL-12.

Go back
773.0, 979.0
30.0, 30.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearBody

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c89 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 15476921, 11894097, 11894098 RIP2-deficient mice have impaired production of IFN-gamma following stimulation of cells with IL-12.

Go back
1069.0, 1023.0
30.0, 30.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m2121*m12340*0.1

nodelay

--

true

0

false

PMID: 15476921, 11894097, 11894098 RIP2-deficient mice have impaired production of IFN-gamma following stimulation of cells with IL-12.

Go back
589.0, 949.0
30.0, 30.0

p33

p35

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearBody

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15476921 NF-B is then free to translocate to the nucleus and drive the expression of genes, many of which are involved in the pro-inflammatory response.

Go back
229.0, 287.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6255*m5*0.1

nodelay

--

true

0

false

PMID: 15476921 LPS binding and signalling through TLR4 involves the LPS binding protein (LBP), CD14 and MD-2.

Go back
153.0, 675.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c21 : 1

m3964*m155701*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR2 has been shown to recognise a number of different PAMPs, including LTA and PGN from Gram-positive bacteria, lipoproteins from Gram-negative bacteria, lipoarabinomannan from Mycobacteria spp. and zymosan, a component of the cell wall from yeast.

Go back
225.0, 587.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c24 : 1

m11*m3964*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR2 has been shown to recognise a number of different PAMPs, including LTA and PGN from Gram-positive bacteria, lipoproteins from Gram-negative bacteria, lipoarabinomannan from Mycobacteria spp. and zymosan, a component of the cell wall from yeast.

Go back
157.0, 731.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c22 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR2 has been shown to recognise a number of different PAMPs, including LTA and PGN from Gram-positive bacteria, lipoproteins from Gram-negative bacteria, lipoarabinomannan from Mycobacteria spp. and zymosan, a component of the cell wall from yeast.

Go back
229.0, 771.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c23 : 1

m3964*m12*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR2 has been shown to recognise a number of different PAMPs, including LTA and PGN from Gram-positive bacteria, lipoproteins from Gram-negative bacteria, lipoarabinomannan from Mycobacteria spp. and zymosan, a component of the cell wall from yeast.

Go back
233.0, 875.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m3964*m17*0.1

nodelay

--

true

0

false

PMID: 15476921 TLR2 has been shown to recognise a number of different PAMPs, including LTA and PGN from Gram-positive bacteria, lipoproteins from Gram-negative bacteria, lipoarabinomannan from Mycobacteria spp. and zymosan, a component of the cell wall from yeast.

Go back
132.0, 103.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 299.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 325.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 276.9876828256433

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 690.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
168.0, 654.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 602.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 609.7235286688388

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
193.1321638494413, 703.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.0, 746.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 706.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0, 152.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
176.0, 790.3393175972478

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 656.4376015698018

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.0, 746.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 801.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 577.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
246.0, 706.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
186.0, 890.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.0, 905.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
191.0, 1006.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 706.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
141.15308596626224, 197.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 1021.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 1143.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
188.7811348571816, 1148.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 1206.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 1276.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.30004000806068, 1270.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 1318.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.29537204140084, 412.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
171.0, 446.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 398.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 263.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
162.0, 524.0793457790559

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
194.41493520678756, 419.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 502.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.0, 242.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 265.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.1756560418076, 188.6984752248576

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 210.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
387.0, 205.71639491289307

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
309.0, 173.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.0, 210.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 138.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.9115249081194, 213.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
523.0, 246.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 269.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 318.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 318.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 374.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 374.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.5610156344095, 333.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.1313651147161, 390.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 466.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
146.97966959864587, 247.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 478.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.3643173537448, 529.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 529.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 613.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 733.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 87.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.0, 218.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 87.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0, 222.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 233.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.0, 381.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 237.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 334.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 345.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 386.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 386.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 400.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 450.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.0, 465.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.13665001533536, 321.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.0, 530.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 376.20633098764773

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 545.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 582.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 597.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 383.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 385.5189395904805

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.5254654449957, 435.59698131770506

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 647.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 690.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 705.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 1009.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 358.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.0, 1062.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1098.6134655807894, 989.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.0, 1059.020613557655

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.1192895849365, 1015.1530859662622

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0, 994.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.9704635488796, 1004.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 1077.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.537002821171, 393.6820865895158

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.4990262892414, 917.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.4839604832151, 979.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back