1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15481153.csml convertedTime:2009.07.01.10:48

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Heterogeneity of TLR-induced responses in dendritic cells: from innate toadaptive immunity.
Authors Re F, Strominger JL.
Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston,MA 02115, USA. fre@utmem.edu
Abstract Toll-like receptors (TLR) mediate recognition of several microbial products.Accumulating evidence indicates that TLR are capable of inducing distinctresponses in dendritic cells and other antigen-presenting cells, and can directT-helper cell differentiation in opposing directions. The generation of suchvaried responses is achieved through the selective utilization of adaptormolecules that link TLR to distinct signal transduction pathways. The ability ofTLR to activate and guide innate and adaptive immunity has the potential to beexploited for practical application that may lead to the development of moresuccessful immunotherapies and vaccination strategies. A review of recentliterature, unpublished observations, and future challenges is presented here.
PMID 15481153
Model Abstract

Entity

G010453:IFN-gamma G010469:IL-4 G010657:IL-12 p40 G010691:CD40 MO000000058:NF-kappaB MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK-1 MO000016573:MyD88 MO000016665:IFNgamma MO000016882:LPS MO000016922:CD40 MO000017265:IL-12 MO000017270:CD86 MO000017793:Lp MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000022185:flagellin MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041441:dsRNA:TLR3:TRIF:TBK1:IKK-i MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000042130:TLR11 MO000066711:CD83 MO000090613:HLA-DRA e1: e10: e100:IRF-7 e101:IRF-9 e102:PKR e103:IFN-beta e104:MCP-5 e105:i-NOS e106:T-bet e107:IL-5 e108:IFN-alpha e109:IFN-alpha e11: e110:PI3K e111:CD86 e112:CD83 e113:HLA-DRA e114:PI3K{activated} e115:caspase-1 e116:caspase-1{activated} e117:i-NOS e12:TLR1: TLR2 e13:TLR2: TLR6 e14:LPS: TLR4 e15:ligand e16:ligand: TLRs e17:LPS: TLR4: MyD88 e18:ligand: TLR: MyD88 e19:ligand: TLR: MyD88: IRAK-1: IRAK-4 e2: e20:LPS: TLR4: MyD88: IRAK-1: IRAK-4 e21:Lp: TLR2: TLR6 e22:PGN: TLR1: TLR2 e23:zymosan: TLR1: TLR2 e24:zymosan e25:lipoarabinomanan e26:lipoarabinomanan: TLR1: TLR2 e27:protein F e28:protein F: TLR4 e29:surfactant protein A e3: e30:surfactant protein A: TLR4 e31:fibronectin fragments e32:fibronectin fragments: TLR4 e33:flagellin: TLR5 e34:ssRNA e35:ssRNA: TLR7 e36:ssRNA: TLR8 e37:imidazoquinoline e38:imidazoquinoline: TLR7 e39:imidazoquinoline: TLR9 e4: e40:CpG DNA e41:CpG DNA: TLR9 e42:uropathogenic bacterial ligand e43:uropathogenic bacterial ligand: TLR11 e44:ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6 e45:NF-kappaB{activated} e46:MAPKs{activated} e47:p38 e48:p38{activated} e49:JNK e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:JNK{activated} e64:ERK1 e65:ERK1{activated} e66:ERK2 e67:ERK2{activated} e68:LPS: TLR4: MAL e69:MAL e7: e70:Lp: TLR2: TLR6: MAL e71:Lp: TLR2: TLR6: MAL: MyD88 e72:TRAM e73:LPS: TLR4: TRAM e74:LPS: TLR4: TRAM: TRIF e75:TBK1: IKK-i e76:IRF-3 e77:IRF-3[activated} e78:IFN-beta e79:IP-10 e8: e80:TLR4 agonist: TLR4 e81:TLR2 agonist: TLR2 e82:IL-12p70 e83:IL-15 e84:IL-8 e85:IL-10 e86:IL-23p19 e87:IL-12p70 e88:IL-12p40 e89:IL-12p40: IL-12p40 e9: e90:IL-12R e91:IL-12p40: IL-12p40: IL-12R e92:IL-12p19 e93:IL-12p40: IL-12p19 e94:IL-12p35 e95:IFNgamma{extracellular} e96:IP-10 e97:IL-15 e98:IFIT1 e99:ISG-15

Process

p1 p10 p100 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
640.0, 1272.0
24.0, 24.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p70

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
609.0, 985.0
21.0, 21.0

IL-4

--

G010469

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p85 p86

--

true true true true

csml-variable:Double

m93439

10

false

infinite

0

unit false false false
TRANSFACG010469

--

Go back
435.0, 1111.0
25.0, 25.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p72 p82 p91

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
767.0, 1055.0
26.0, 26.0

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p51 p50

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false

--

Go back
925.0, 891.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p40 p42 p47 p49

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
917.0, 819.0
30.5, 30.5

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p39 p41 p46 p48

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
889.0, 552.0
29.0, 29.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
926.0, 386.0
28.0, 28.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
949.0, 343.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4 p32

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
696.0, 1352.0
24.0, 24.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p74

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1181.0, 227.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p96

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
954.0, 1068.0
27.5, 27.5

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p50

p58

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
586.0, 1354.0
27.0, 27.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
957.0, 1111.0
30.0, 30.0

CD86

--

MO000017270

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52 p53

p58

true true true true

csml-variable:Double

m2126

10

false

infinite

0

unit false false false

--

Go back
450.0, 62.0
28.5, 28.5

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
1055.0, 225.0
27.0, 27.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p13 p14 p15

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1059.0, 392.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
316.0, 450.0
26.0, 26.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
267.0, 823.0
26.0, 26.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
162.0, 818.0
27.5, 27.5

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
174.0, 448.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
891.0, 484.0
28.0, 28.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
521.5, 402.0
28.5, 28.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p34

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
349.0, 379.0
32.0, 32.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p35

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
397.0, 363.0
24.5, 24.5

dsRNA:TLR3:TRIF:TBK1:IKK-i

--

MO000041441

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p36 p39 p40

true true true true

csml-variable:Double

m19309

10

false

infinite

0

unit false false false
TRANSPATHMO000041441

--

Go back
314.0, 400.0
29.0, 29.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p11 p95

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
315.0, 625.0
26.5, 26.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p20

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
339.0, 760.0
28.0, 28.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
129.0, 335.0
24.0, 24.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
321.0, 507.0
23.5, 23.5

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p19

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
263.0, 914.0
28.0, 28.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
962.0, 1160.0
28.0, 28.0

CD83

--

MO000066711

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p55

p58

true true true true

csml-variable:Double

m41568

10

false

infinite

0

unit false false false
TRANSPATHMO000066711

--

Go back
962.0, 1208.0
28.0, 28.0

HLA-DRA

--

MO000090613

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p57

p58

true true true true

csml-variable:Double

m64140

10

false

infinite

0

unit false false false
TRANSPATHMO000090613

--

Go back
240.75, 194.9969080091176
873.9706975133364, 1269.005452789363

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
249.0, 214.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
607.5, 1119.0
33.99653979238755, 18.13148788927336

IRF-7

--

e100

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p77

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
619.5, 1151.0
33.99653979238755, 18.13148788927336

IRF-9

--

e101

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p78

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
630.5, 1179.0
35.19031141868513, 18.768166089965394

PKR

--

e102

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p79

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
315.5, 1065.125
33.84282551821292, 20.86974240289797

IFN-beta

--

e103

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p80 p89

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
730.5, 1022.0
39.186851211072664, 20.899653979238753

MCP-5

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p81

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
802.5, 995.0
34.775086505190316, 18.546712802768166

i-NOS

--

e105

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p83

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
434.5, 975.0
35.24221453287198, 18.795847750865054

T-bet

--

e106

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p84

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
746.5, 991.0
34.0484429065744, 18.15916955017301

IL-5

--

e107

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87 p88 p95

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
320.5, 1282.125
31.51237673576172, 19.432632320386396

IFN-alpha

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

p90

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
419.5, 1211.0
33.11418685121107, 17.66089965397924

IFN-alpha

--

e109

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p94

p90

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
321.72015625888906, 382.7107693474674
249.4820700510114, 416.5082016953327

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
754.5, 433.0
18.756892734956732, 30.41658281344335

PI3K

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p99

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
760.0, 1087.0
32.95847750865052, 17.577854671280278

CD86

--

e111

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p52 p53

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
762.0, 1146.0
36.0726643598616, 19.238754325259517

CD83

--

e112

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p54 p55

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
763.0, 1203.0
33.581314878892734, 17.910034602076127

HLA-DRA

--

e113

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p56 p57

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
754.5, 477.0
18.756892734956732, 30.41658281344335

PI3K{activated}

--

e114

cso30:c:Protein

cso30:i:CC_Cytosol

--

p99

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
757.0, 528.0
13.693171188026191, 31.599625818521982

caspase-1

--

e115

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p100

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
757.0, 572.0
13.693171188026191, 31.599625818521982

caspase-1{activated}

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

p100

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
966.5, 981.125
34.072247937210705, 21.011219561279937

i-NOS

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

p83

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
253.0, 272.5
39.040000000000006, 29.279999999999998

TLR1: TLR2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p8 p10 p12

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
398.0, 208.5
38.72, 29.04

TLR2: TLR6

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1058.5, 174.0
28.31728045325779, 34.67422096317281

LPS: TLR4

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p30 p33 p59 p60 p61 p62 p71 p75 p76 p77 p78 p79 p86 p87

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1186.5, 392.375
34.77152899824253, 22.601493848857643

ligand

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1053.625, 430.5
31.05061656390602, 38.021163139476755

ligand: TLRs

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p4 p43 p44 p45 p98 p99 p100

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
950.875, 159.5
28.114929344833914, 39.23013396953569

LPS: TLR4: MyD88

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1053.875, 477.5
29.606395668930077, 41.311249770600114

ligand: TLR: MyD88

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1052.875, 535.5
32.25, 45.0

ligand: TLR: MyD88: IRAK-1: IRAK-4

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p23

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
240.75, 194.9969080091176
873.9706975133364, 1269.005452789363

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
889.875, 170.5
29.472242613323544, 41.12405946045146

LPS: TLR4: MyD88: IRAK-1: IRAK-4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
451.875, 196.5
26.22100385391815, 36.58744723802533

Lp: TLR2: TLR6

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p31 p38 p60 p61 p63 p64 p65 p72 p85 p88

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
262.875, 307.5
27.507294916498438, 38.38227197650945

PGN: TLR1: TLR2

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
264.875, 220.5
32.25, 45.0

zymosan: TLR1: TLR2

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
126.5, 189.375
28.79613356766257, 18.71748681898067

zymosan

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
140.5, 161.25
38.515559293523964, 21.82548359966358

lipoarabinomanan

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
299.875, 196.5
25.889566893007895, 36.124977060011005

lipoarabinomanan: TLR1: TLR2

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1182.0, 273.25
30.0, 19.5

protein F

--

e27

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1056.75, 268.0
24.5, 30.0

protein F: TLR4

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1181.5, 312.375
31.46748681898066, 20.453866432337435

surfactant protein A

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
258.2294139502667, 212.47632195938434
839.011869612803, 1234.0466248888306

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1056.75, 308.0
24.5, 30.0

surfactant protein A: TLR4

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1181.5, 360.25
39.70142977291842, 22.497476871320433

fibronectin fragments

--

e31

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1054.625, 353.5
29.050116647225465, 35.57157140476587

fibronectin fragments: TLR4

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
262.625, 867.5
27.629353441093148, 33.83186135644059

flagellin: TLR5

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
166.5, 547.625
37.93666026871401, 20.865163147792707

ssRNA

--

e34

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p17 p18

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
330.625, 543.5
27.449716713881024, 33.611898016997166

ssRNA: TLR7

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p90 p91 p94

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
306.625, 665.5
27.53953507748708, 33.72187968671888

ssRNA: TLR8

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
163.5, 630.25
40.78637510513036, 23.11227922624054

imidazoquinoline

--

e37

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p19 p20

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
320.625, 583.5
23.807990334944172, 29.152641226462254

imidazoquinoline: TLR7

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p19

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
317.625, 716.5
22.256582236293948, 27.25295784035994

imidazoquinoline: TLR9

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p20

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
290.5663297582603, 243.06529637235093
774.3380379968163, 1172.868676062896

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
166.5, 766.125
45.0, 15.75

CpG DNA

--

e40

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
395.625, 777.5
27.319071821363103, 33.45192467922013

CpG DNA: TLR9

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p84 p97

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
164.5, 918.375
30.483304042179256, 19.81414762741652

uropathogenic bacterial ligand

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
263.625, 960.5
25.89014330944843, 31.702216297283787

uropathogenic bacterial ligand: TLR11

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1052.875, 599.5
29.472242613323544, 41.12405946045146

ligand: TLR: MyD88: IRAK-1: IRAK-4: TRAF6

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p24 p25 p26 p27 p28 p29

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
925.0, 931.0
30.0, 30.0

NF-kappaB{activated}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p40 p42 p47 p49

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
917.0, 855.0
30.5, 30.5

MAPKs{activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p39 p41 p46 p48

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
903.0, 613.5
27.325417589052126, 16.85067417991548

p38

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
901.0, 637.5
30.392433085127795, 18.742000402495474

p38{activated}

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
903.0, 666.5
26.99939625679211, 16.64962769168847

JNK

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
321.72015625888906, 382.7107693474674
249.4820700510114, 416.5082016953327

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
357.3520887167055, 871.0598034775793
512.9956387549516, 465.2306817014177

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
412.7594388988045, 882.0850942948747
299.9639302961917, 450.9011945853577

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
364.0391827042002, 877.2692478945388
499.6214507799624, 452.81179286749904

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
364.99448184527097, 878.2245470356094
497.71085249782095, 450.9011945853577

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
357.3520887167055, 871.0598034775793
512.9956387549516, 465.2306817014177

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
357.3520887167055, 871.0598034775793
512.9956387549516, 465.2306817014177

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
364.99448184527097, 878.2245470356094
497.71085249782095, 450.9011945853577

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
731.8293520164094, 1062.1196316917137
32.04914885278235, 29.012913698308246

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
647.76302760219, 1195.8615114416082
90.75341840171397, 82.15572613207794

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
357.3520887167055, 871.0598034775793
512.9956387549516, 465.2306817014177

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
321.72015625888906, 382.7107693474674
249.4820700510114, 416.5082016953327

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
478.2622743434655, 1077.8044741929198
16.245818111456867, 7.822060572182932

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
477.71978049161027, 1054.4772385631484
55.60561981515144, 100.09011566727249

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
501.0470161213817, 1119.5765007857653
8.679901629682167, 8.67990162968216

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
903.0, 689.5
27.615214328838796, 17.029382169450592

JNK{activated}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
906.0, 716.5
29.824914469712215, 18.392030589655864

ERK1

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
908.0, 745.5
26.54055141879654, 16.36667337492453

ERK1{activated}

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
905.5, 768.125
31.850472932179514, 19.641124974844033

ERK2

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
909.5, 796.125
31.850472932179514, 19.641124974844033

ERK2{activated}

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
991.875, 172.5
27.041704899981646, 37.732611488346485

LPS: TLR4: MAL

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p3

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
770.125, 264.5
19.469863151539542, 31.572751056550608

MAL

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30 p31

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
252.0, 200.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
489.875, 182.5
29.472242613323544, 41.12405946045146

Lp: TLR2: TLR6: MAL

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p32

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
540.875, 172.5
32.25, 45.0

Lp: TLR2: TLR6: MAL: MyD88

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
851.125, 299.5
19.14967800362246, 31.05353189776615

TRAM

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
845.875, 182.5
29.606395668930077, 41.31124977060011

LPS: TLR4: TRAM

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p33

p34

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
800.875, 196.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p34

p41 p42

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
445.625, 294.5
27.808990168305282, 34.051824695884015

TBK1: IKK-i

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
554.5, 381.125
34.62769168846851, 21.35374320788891

IRF-3

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36 p98

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
558.5, 741.125
34.62769168846851, 21.35374320788891

IRF-3[activated}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36 p98

p37 p38

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
517.5, 978.0
37.110726643598625, 19.792387543252595

IFN-beta

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37 p59 p97

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
576.5, 1020.0
31.712802768166092, 16.913494809688583

IP-10

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38 p60 p89

p73

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
255.0, 221.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1070.625, 1011.5
27.359898350274957, 33.501916347275454

TLR4 agonist: TLR4

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p46 p47 p81 p82 p92 p51 p52 p54 p56 p83

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1068.625, 1061.5
29.899308448591906, 36.61139810031661

TLR2 agonist: TLR2

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p48 p49 p89 p93 p50 p53 p55 p57

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
681.5, 1226.0
37.110726643598625, 19.792387543252595

IL-12p70

--

e82

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

p66

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
597.5, 1214.0
37.99307958477509, 20.262975778546714

IL-15

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p62

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
454.5, 1007.0
39.550173010380625, 21.093425605536332

IL-8

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p63

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
456.5, 1045.0
35.294117647058826, 18.823529411764707

IL-10

--

e85

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
441.5, 1078.0
37.110726643598625, 19.792387543252595

IL-23p19

--

e86

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
966.5, 1253.125
34.579392231837396, 21.323958542966395

IL-12p70

--

e87

cso30:c:Protein

cso30:i:CC_Cytosol

--

p66

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
854.5, 1307.125
27.72086939021936, 17.094536123968602

IL-12p40

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p66 p67 p69

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
975.625, 1301.5
23.93863522746209, 29.312614564239293

IL-12p40: IL-12p40

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
265.0, 250.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1071.375, 1301.5
24.26933216168717, 37.33743409490334

IL-12R

--

e90

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p68

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1068.375, 1345.5
23.25, 45.0

IL-12p40: IL-12p40: IL-12R

--

e91

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p68

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
751.5, 1306.125
32.29724290601732, 19.91663312537734

IL-12p19

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p69

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
756.625, 1341.5
22.991459756707215, 28.152807865355772

IL-12p40: IL-12p19

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
562.5, 1239.0
34.67128027681661, 18.49134948096886

IL-12p35

--

e94

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p71

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
524.0, 1452.0
24.0, 24.0

IFNgamma{extracellular}

--

e95

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p73

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
446.5, 1341.125
34.19299657878849, 21.085681223586235

IP-10

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p73

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
855.5, 1361.125
33.75830146910847, 20.817619239283555

IL-15

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p74

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
585.5, 1054.0
36.33217993079586, 19.377162629757784

IFIT1

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p75

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
594.5, 1087.0
34.0484429065744, 18.15916955017301

ISG-15

--

e99

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p76

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1129.0, 227.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR4 is a receptor for Gram- LPS, Respiratory syncytial virus protein F, and other endogenous ligands, such as surfactant protein A and fibronectin fragment.

Go back
128.0, 230.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e12

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m25*m12*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2, in combination with either TLR1 or TLR6, recognizes several products including peptidoglycan, bacterial lipopeptides, mycobacterial lipoarabinomannan, and yeast zymosan.

Go back
799.0, 531.0
26.0, 26.0

p100

p100

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e115 e16

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c262 : 1
stoichiometry:c261 : 1

m117*m16*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
433.0, 403.0
24.0, 24.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 15481153, 12539043, 12855817, 12692549 This pathway relies on a third adaptor called TRIF/TICAM (Oshiumi et al., 2003; Yamamoto et al., 2003a) that links TLR3 and TLR4 to the kinase complex IKKepsilon/TBK1, which in turn activates the transcription factor IRF3.

Go back
212.0, 158.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e12 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m12*m26*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2, in combination with either TLR1 or TLR6, recognizes several products including peptidoglycan, bacterial lipopeptides, mycobacterial lipoarabinomannan, and yeast zymosan.

Go back
1128.0, 270.0
26.0, 26.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m3961*m28*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR4 is a receptor for Gram- LPS, Respiratory syncytial virus protein F, and other endogenous ligands, such as surfactant protein A and fibronectin fragment.

Go back
1128.0, 310.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m3961*m30*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR4 is a receptor for Gram- LPS, Respiratory syncytial virus protein F, and other endogenous ligands, such as surfactant protein A and fibronectin fragment.

Go back
1128.0, 358.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e31 MO000019394

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m32*m3961*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR4 is a receptor for Gram- LPS, Respiratory syncytial virus protein F, and other endogenous ligands, such as surfactant protein A and fibronectin fragment.

Go back
163.0, 871.0
26.0, 26.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR5 recognizes bacterial flagellin.

Go back
248.0, 506.0
26.0, 26.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e34 MO000042126

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m35*m19940*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR7 and TLR8 are receptors for ssRNA found in endosomal compartments and antiviral imidazoquinoline drugs that are structural mimetics of ssRNA.

Go back
247.0, 625.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000042007 e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m19823*m35*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR7 and TLR8 are receptors for ssRNA found in endosomal compartments and antiviral imidazoquinoline drugs that are structural mimetics of ssRNA.

Go back
248.0, 585.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e37 MO000042126

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m38*m19940*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR7 and TLR8 are receptors for ssRNA found in endosomal compartments and antiviral imidazoquinoline drugs that are structural mimetics of ssRNA.

Go back
1131.0, 391.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019395 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m3962*m15*0.1

nodelay

--

true

0

false

PMID: 15481153, 14620134, 12960260 TLR belong to a family of PRR that are used to recognize microbial products derived from several classes of microbes, as well as endogenous ligands that represent ¡Æ¡Ædanger signal¡Ç¡Ç.

Go back
248.0, 717.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e37 MO000042007

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m38*m19823*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR7 and TLR8 are receptors for ssRNA found in endosomal compartments and antiviral imidazoquinoline drugs that are structural mimetics of ssRNA.

Go back
245.0, 762.0
23.0, 23.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042012 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m19828*m41*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR9 mediates responses to bacterial CpG DNA.

Go back
168.0, 964.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000042130

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m43*m19944*0.1

nodelay

--

true

0

false

PMID: 15481153, 15001781 TLR11 mediates response to uropathogenic bacteria, although the nature of the agonist has not been identified.

Go back
973.0, 546.0
24.0, 24.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000000212

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c70 : 1
stoichiometry:c69 : 1

m20*m183*0.1

nodelay

--

true

0

false

PMID: 15481153 This molecule links all TLR, with the possible exception of TLR3, to the complex IRAK1/4- TRAF6, which then leads to the activation of canonical NF-kappaB and MAPKs.

Go back
967.0, 877.0
25.0, 25.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m19*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 This molecule links all TLR, with the possible exception of TLR3, to the complex IRAK1/4- TRAF6, which then leads to the activation of canonical NF-kappaB and MAPKs.

Go back
983.0, 799.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c76 : 1
stoichiometry:c74 : 1

m69*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 This molecule links all TLR, with the possible exception of TLR3, to the complex IRAK1/4- TRAF6, which then leads to the activation of canonical NF-kappaB and MAPKs.

Go back
964.0, 609.0
25.0, 25.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e44

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c78 : 1

m48*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
965.0, 662.0
24.0, 24.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e44

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m63*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
964.0, 713.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 e44

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m65*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
965.0, 766.0
23.0, 23.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e66 e44

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m67*m45*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
953.0, 299.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e68

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c94 : 1
stoichiometry:c8 : 1

m1572*m70*0.1

nodelay

--

true

0

false

Go back
993.0, 267.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e14

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m71*m14*0.1

nodelay

--

true

0

false

PMID: 15481153, 11544529, 11526399 The activation of this pathway by TLR2 and TLR4 is dependent on an additional TIR-containing adaptor called TIRAP/MALthat works in conjunction with MyD88.

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493.0, 267.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e21

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m71*m22*0.1

nodelay

--

true

0

false

PMID: 15481153, 11544529, 11526399 The activation of this pathway by TLR2 and TLR4 is dependent on an additional TIR-containing adaptor called TIRAP/MALthat works in conjunction with MyD88.

Go back
544.0, 346.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000016573

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m72*m1572*0.1

nodelay

--

true

0

false

PMID: 15481153, 11544529, 11526399 The activation of this pathway by TLR2 and TLR4 is dependent on an additional TIR-containing adaptor called TIRAP/MALthat works in conjunction with MyD88.

Go back
849.0, 251.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 e14

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m74*m14*0.1

nodelay

--

true

0

false

PMID: 15481153, 14556004 TRAM, the most recently characterized TIR-containing adaptor, also appears to be required for both MyD88-dependent and MyD88-independent responses induced by TLR4.

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804.0, 306.0
25.0, 25.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m18998*m75*0.1

nodelay

--

true

0

false

PMID: 15481153, 12539043, 12855817, 12692549 This pathway relies on a third adaptor called TRIF/TICAM (Oshiumi et al., 2003; Yamamoto et al., 2003a) that links TLR3 and TLR4 to the kinase complex IKKepsilon/TBK1, which in turn activates the transcription factor IRF3.

Go back
396.0, 302.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041437 e75

MO000041441

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m19305*m77*0.1

nodelay

--

true

0

false

PMID: 15481153, 12539043, 12855817, 12692549 This pathway relies on a third adaptor called TRIF/TICAM (Oshiumi et al., 2003; Yamamoto et al., 2003a) that links TLR3 and TLR4 to the kinase complex IKKepsilon/TBK1, which in turn activates the transcription factor IRF3.

Go back
563.0, 455.0
25.0, 25.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 MO000041441

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m78*m19309*0.1

nodelay

--

true

0

false

PMID: 15481153, 12539043, 12855817, 12692549 This pathway relies on a third adaptor called TRIF/TICAM (Oshiumi et al., 2003; Yamamoto et al., 2003a) that links TLR3 and TLR4 to the kinase complex IKKepsilon/TBK1, which in turn activates the transcription factor IRF3.

Go back
532.0, 912.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c110 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 15481153, 12354379, 11698465 IRF3 is responsible for the induction of a group of genes specific for TLR3/4 stimulation, such as IFN-beta and IP-10. PMID: 15481153 For example, in human DC TLR3 is able to induce IP-10 and IL-15 to similar levels as TLR4, yet it induces IFN-beta only very weakly.

Go back
532.0, 1016.0
23.0, 23.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e21

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c229 : 1
stoichiometry:c111 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 15481153, 12354379, 11698465 IRF3 is responsible for the induction of a group of genes specific for TLR3/4 stimulation, such as IFN-beta and IP-10. PMID: 15481153 Thus, while TLR2 activation is unable to induce Th1-specific factors (IP-10, IFN-beta, IL-12, and IL-15), it is at the same time capable of blocking the induction of some of them (IL-12 and IP-10) by TLR4 and TLR3. PMID: 15481153 For example, in human DC TLR3 is able to induce IP-10 and IL-15 to similar levels as TLR4, yet it induces IFN-beta only very weakly.

Go back
868.0, 822.0
23.0, 23.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 MO000041441

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c118 : 1
stoichiometry:c115 : 1

m69*m19309*0.1

nodelay

--

true

0

false

PMID: 15481153 Furthermore, TRIF is capable of leading to the activation of NF-kappaB and MAPKs, and appears to be the only adaptor used by TLR3.

Go back
997.0, 438.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e16

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m1572*m16*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR also contain a highly conserved cytoplasmic Toll-IL-1 receptor (TIR) domain that, through the adaptor molecule MyD88, connects the receptor to the intracellular signaling machinery shared by IL-1 and IL-18.

Go back
852.0, 894.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000041441

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c119 : 1
stoichiometry:c117 : 1

m19*m19309*0.1

nodelay

--

true

0

false

PMID: 15481153 Furthermore, TRIF is capable of leading to the activation of NF-kappaB and MAPKs, and appears to be the only adaptor used by TLR3.

Go back
847.0, 857.0
25.0, 25.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 MO000000077

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m76*m69*0.1

nodelay

--

true

0

false

PMID: 15481153 Furthermore, TRIF is capable of leading to the activation of NF-kappaB and MAPKs, and appears to be the only adaptor used by TLR3.

Go back
832.0, 934.0
24.0, 24.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 MO000000058

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m76*m19*0.1

nodelay

--

true

0

false

PMID: 15481153 Furthermore, TRIF is capable of leading to the activation of NF-kappaB and MAPKs, and appears to be the only adaptor used by TLR3.

Go back
1187.0, 465.0
27.0, 27.0

p43

p43

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR signaling initiates DC maturation, a differentiation process in which the antigen is captured and processed into peptides that are then presented in the context of MHC class II molecules.

Go back
1189.0, 511.0
24.0, 24.0

p44

p44

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15481153 Various TLR agonists activate mast cells, eosinophil, neutrophils, B cells, endothelial cells, and several types of epithelia, and regulate proliferation and apoptosis of different cell types.

Go back
1191.0, 553.0
27.0, 27.0

p45

p45

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e16

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 15481153 Various TLR agonists activate mast cells, eosinophil, neutrophils, B cells, endothelial cells, and several types of epithelia, and regulate proliferation and apoptosis of different cell types.

Go back
1016.0, 822.0
23.0, 23.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000077 e80

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c137 : 1
stoichiometry:c130 : 1

m69*m82*0.1

nodelay

--

true

0

false

PMID: 15481153 NF-kappaB and MAPK family members were activated to the same extent and with similar kinetics by both TLR2 and TLR4 agonists in the DC.

Go back
1016.0, 894.0
23.0, 23.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000058 e80

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c138 : 1
stoichiometry:c134 : 1

m19*m82*0.1

nodelay

--

true

0

false

PMID: 15481153 NF-kappaB and MAPK family members were activated to the same extent and with similar kinetics by both TLR2 and TLR4 agonists in the DC.

Go back
1015.0, 857.0
25.0, 25.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000000077 e81

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c139 : 1
stoichiometry:c132 : 1

m69*m83*0.1

nodelay

--

true

0

false

PMID: 15481153 NF-kappaB and MAPK family members were activated to the same extent and with similar kinetics by both TLR2 and TLR4 agonists in the DC.

Go back
990.0, 930.0
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000000058 e81

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c140 : 1
stoichiometry:c136 : 1

m19*m83*0.1

nodelay

--

true

0

false

PMID: 15481153 NF-kappaB and MAPK family members were activated to the same extent and with similar kinetics by both TLR2 and TLR4 agonists in the DC.

Go back
244.0, 450.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR3 mediates responses to viral dsRNA.

Go back
895.0, 1059.0
25.0, 25.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e81 G010691

MO000016922

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c247 : 1

m83*m93612*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2 and TLR4 agonists were also equally capable of inducing DC maturation as measured by the up-regulation of several cell surface markers such as CD40, CD86, HLA-DR, and CD83.

Go back
896.0, 1032.0
23.0, 23.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010691 e80

MO000016922

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c240 : 1
stoichiometry:c142 : 1

m93612*m82*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2 and TLR4 agonists were also equally capable of inducing DC maturation as measured by the up-regulation of several cell surface markers such as CD40, CD86, HLA-DR, and CD83.

Go back
900.0, 1088.0
23.0, 23.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e111 e80

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c248 : 1
stoichiometry:c145 : 1

m113*m82*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2 and TLR4 agonists were also equally capable of inducing DC maturation as measured by the up-regulation of several cell surface markers such as CD40, CD86, HLA-DR, and CD83.

Go back
896.0, 1112.0
23.0, 23.0

p53

p53

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e111 e81

MO000017270

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c249 : 1
stoichiometry:c146 : 1

m113*m83*0.1

nodelay

--

true

0

false

--

Go back
896.0, 1140.0
23.0, 23.0

p54

p54

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e80 e112

MO000066711

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c250 : 1
stoichiometry:c149 : 1

m82*m114*0.1

nodelay

--

true

0

false

--

Go back
896.0, 1168.0
23.0, 23.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e81 e112

MO000066711

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c251 : 1
stoichiometry:c150 : 1

m83*m114*0.1

nodelay

--

true

0

false

--

Go back
896.0, 1196.0
23.0, 23.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e80 e113

MO000090613

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c252 : 1
stoichiometry:c153 : 1

m82*m115*0.1

nodelay

--

true

0

false

--

Go back
891.0, 1227.0
25.0, 25.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_NuclearOuterMembrane

--

e81 e113

MO000090613

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c253 : 1
stoichiometry:c154 : 1

m83*m115*0.1

nodelay

--

true

0

false

--

Go back
1145.0, 1145.0
30.0, 30.0

p58

p58

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016922 MO000017270 MO000066711 MO000090613

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m1837*m2126*m41568*m64140*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2 and TLR4 agonists were also equally capable of inducing DC maturation as measured by the up-regulation of several cell surface markers such as CD40, CD86, HLA-DR, and CD83.

Go back
576.0, 976.0
23.0, 23.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c161 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Among the several cytokines and chemokines that were analyzed, IL-12p70, IP-10, IFNb, and IL-15 expression was exclusively induced by the TLR4 agonist LPS and not by TLR2 agonists. PMID: 15481153 IFN-beta, IFIT1, and ISG15 belong to the primary response group.

Go back
973.0, 486.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 MO000000213 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c19 : 1
stoichiometry:c18 : 1

m17258*m184*m18*0.1

nodelay

--

true

0

false

PMID: 15481153 This molecule links all TLR, with the possible exception of TLR3, to the complex IRAK1/4- TRAF6, which then leads to the activation of canonical NF-kappaB and MAPKs.

Go back
628.0, 1016.0
23.0, 23.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14 e21

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c230 : 1
stoichiometry:c162 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Among the several cytokines and chemokines that were analyzed, IL-12p70, IP-10, IFNb, and IL-15 expression was exclusively induced by the TLR4 agonist LPS and not by TLR2 agonists. PMID: 15481153, 15001781 IP-10 also appears to be part of this group, although it has been suggested otherwise. PMID: 15481153 Thus, while TLR2 activation is unable to induce Th1-specific factors (IP-10, IFN-beta, IL-12, and IL-15), it is at the same time capable of blocking the induction of some of them (IL-12 and IP-10) by TLR4 and TLR3.

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687.0, 1271.0
25.0, 25.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14 e21

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c231 : 1
stoichiometry:c163 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Among the several cytokines and chemokines that were analyzed, IL-12p70, IP-10, IFNb, and IL-15 expression was exclusively induced by the TLR4 agonist LPS and not by TLR2 agonists. PMID: 15481153 Thus, while TLR2 activation is unable to induce Th1-specific factors (IP-10, IFN-beta, IL-12, and IL-15), it is at the same time capable of blocking the induction of some of them (IL-12 and IP-10) by TLR4 and TLR3.

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603.0, 1291.0
25.0, 25.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c164 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Among the several cytokines and chemokines that were analyzed, IL-12p70, IP-10, IFN-beta, and IL-15 expression was exclusively induced by the TLR4 agonist LPS and not by TLR2 agonists. PMID: 15481153 It is currently unclear as to what group other TLR4-specific genes, such as IL12p35 and IL-15, belong to.

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410.0, 1006.0
23.0, 23.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c169 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 In contrast, TLR2 agonists preferentially induced IL-8, IL-10, and IL-23p19.

Go back
395.0, 1039.0
25.0, 25.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c170 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 In contrast, TLR2 agonists preferentially induced IL-8, IL-10, and IL-23p19.

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384.0, 1076.0
23.0, 23.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c171 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 In contrast, TLR2 agonists preferentially induced IL-8, IL-10, and IL-23p19.

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811.0, 1251.0
25.0, 25.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e82 e88

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 15481153 The p40 subunit is expressed in large excess of the p35 subunit, which is the limiting factor in controlling IL-12p70 production.

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928.0, 1304.0
23.0, 23.0

p67

p67

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e88

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 15481153 IL-12p40 can also form homodimers that act as IL-12 receptor antagonist, or can pair with p19 to form IL-23, a novel cytokine whose activities remain poorly characterized.

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975.0, 1355.0
26.0, 26.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e90 e89

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m92*m91*0.1

nodelay

--

true

0

false

PMID: 15481153 IL-12p40 can also form homodimers that act as IL-12 receptor antagonist, or can pair with p19 to form IL-23, a novel cytokine whose activities remain poorly characterized.

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804.0, 1304.0
23.0, 23.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e92 e88

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m94*m90*0.1

nodelay

--

true

0

false

PMID: 15481153 IL-12p40 can also form homodimers that act as IL-12 receptor antagonist, or can pair with p19 to form IL-23, a novel cytokine whose activities remain poorly characterized.

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893.0, 299.0
24.0, 24.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 MO000000213

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c20 : 1
stoichiometry:c22 : 1

m17258*m184*0.1

nodelay

--

true

0

false

Go back
643.0, 1351.0
25.0, 25.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 MO000017265

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c186 : 1

m93423*m2121*0.1

nodelay

--

true

0

false

PMID: 15481153, 12563297 IL-12 is able to stimulate IFN-gamma production in T cells, and is the key cytokine that directs the development of human and murine Th1 cells.

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568.0, 1288.0
23.0, 23.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c189 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that TLR4, but not TLR2, is able to induce the p35 subunit of IL-12, suggests that the Th1/ Th2 balance may be directly affected by the action of TLR. PMID: 15481153 It is currently unclear as to what group other TLR4-specific genes, such as IL12p35 and IL-15, belong to.

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384.0, 1112.0
23.0, 23.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c191 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 It is remarkable that TLR2 stimulation, while failing to induce IL-12p70 release due to defective p35 gene induction, is nevertheless still able to stimulate.

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522.0, 1338.0
27.0, 27.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e95 e79

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1
stoichiometry:c193 : 1

m97*m81*0.1

nodelay

--

true

0

false

PMID: 15481153 IP-10, a CXC chemokine produced by different cell types in response to IFN-gamma and microbial products, is a chemoattractant for monocytes, NK cells, and, importantly, Th1 cells that preferentially express the IP-10 receptor CXCR3.

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695.0, 1411.0
25.0, 25.0

p74

p74

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e97 MO000016665

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m99*m1639*0.1

nodelay

--

true

0

false

PMID: 15481153 IL-15 is particularly active on NK cells and strongly induces IFN-gamma release by this cell type.

Go back
641.0, 1053.0
21.0, 21.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 IFN-beta, IFIT1, and ISG15 belong to the primary response group.

Go back
656.0, 1084.0
23.0, 23.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c201 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 IFN-beta, IFIT1, and ISG15 belong to the primary response group.

Go back
669.0, 1117.0
21.0, 21.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c203 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 The secondary response group comprises interferon response genes, such as RF7, IRF9, and PKR.

Go back
680.0, 1148.0
23.0, 23.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c204 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 The secondary response group comprises interferon response genes, such as RF7, IRF9, and PKR.

Go back
692.0, 1176.0
23.0, 23.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c205 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 The secondary response group comprises interferon response genes, such as RF7, IRF9, and PKR.

Go back
129.0, 275.0
24.0, 24.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 MO000042032

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m12*m155701*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2, in combination with either TLR1 or TLR6, recognizes several products including peptidoglycan, bacterial lipopeptides, mycobacterial lipoarabinomannan, and yeast zymosan.

Go back
198.0, 1058.0
27.0, 27.0

p80

p80

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e103

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 15481153 Finally, IFN-beta is a type I interferon that induces Th1 differentiation in humans.

Go back
790.0, 1020.0
23.0, 23.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c210 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 15481153 Stimulation with TLR4 agonist led to the production of IP-10, IFN-beta, MCP5, iNOS, and IL-12p40.

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384.0, 1144.0
23.0, 23.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e80

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 15481153 Stimulation with TLR4 agonist led to the production of IP-10, IFN-beta, MCP5, iNOS, and IL-12p40.

Go back
894.0, 978.0
27.0, 27.0

p83

p83

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e105 e80

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c263 : 1
stoichiometry:c214 : 1

m107*m82*0.1

nodelay

--

true

0

false

PMID: 15481153 Stimulation with TLR4 agonist led to the production of IP-10, IFN-beta, MCP5, iNOS, and IL-12p40.

Go back
488.0, 972.0
23.0, 23.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15481153, 12766768 In murine B cells, CpG DNA (TLR9 agonist), but not LPS, was found to induce the transcription factor T-bet and inhibit IgG1 and IgE switching induced by IL-4.

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592.0, 928.0
23.0, 23.0

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010469

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c218 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 Moreover, the Th2 cytokines IL-4 and IL-5 were more abundantly released by mast cells stimulated through TLR2 than TLR4.

Go back
616.0, 940.0
23.0, 23.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G010469

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c219 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Moreover, the Th2 cytokines IL-4 and IL-5 were more abundantly released by mast cells stimulated through TLR2 than TLR4.

Go back
763.0, 947.0
25.0, 25.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c222 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 15481153 Moreover, the Th2 cytokines IL-4 and IL-5 were more abundantly released by mast cells stimulated through TLR2 than TLR4.

Go back
712.0, 956.0
23.0, 23.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c223 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 15481153 Moreover, the Th2 cytokines IL-4 and IL-5 were more abundantly released by mast cells stimulated through TLR2 than TLR4.

Go back
492.0, 1064.0
23.0, 23.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e103 e81

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c228 : 1
stoichiometry:c227 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 15481153 Preincubation with TLR2 agonist also blocked the induction of IP-10 by IFN-beta, suggesting that the mechanism of inhibition is not specific for TLR, or due to rapid tolerization, but rather is more proximal and restricted to the transcription of those genes.

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452.0, 118.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000017793

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m13*m2549*0.1

nodelay

--

true

0

false

PMID: 15481153 TLR2, in combination with either TLR1 or TLR6, recognizes several products including peptidoglycan, bacterial lipopeptides, mycobacterial lipoarabinomannan, and yeast zymosan.

Go back
324.0, 1213.0
23.0, 23.0

p90

p90

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e109 e35

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c255 : 1
stoichiometry:c232 : 1

m111*m36*0.1

nodelay

--

true

0

false

PMID: 15481153, 12045249 Plasmacytoid cells respond by producing IFN-alpha, while myeloid DC preferentially express IL-12.

Go back
423.0, 1171.0
25.0, 25.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c234 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15481153, 12045249 Plasmacytoid cells respond by producing IFN-alpha, while myeloid DC preferentially express IL-12.

Go back
1149.0, 1005.0
29.0, 29.0

p92

p92

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e80

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 15481153, 14607893, 14579266, 12761116 The ability of TLR2 and TLR4 to induce distinct Th responses was confirmed in humans by in vitro Th cell differentiation experiments, and found to mirror the results obtained in mice, such that TLR2 agonists induced Th2 diffrentiation and TLR4 induced Th1.

Go back
1153.0, 1065.0
30.0, 30.0

p93

p93

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e81

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 15481153, 14607893, 14579266, 12761116 The ability of TLR2 and TLR4 to induce distinct Th responses was confirmed in humans by in vitro Th cell differentiation experiments, and found to mirror the results obtained in mice, such that TLR2 agonists induced Th2 diffrentiation and TLR4 induced Th1.

Go back
424.0, 1248.0
23.0, 23.0

p94

p94

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c239 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15481153, 12045249, 11812998 Similarly, TLR7 can induce IFN-alpha in human plasmacytoid DC (Ito et al., 2002) despite its inability to activate MyD88-independent signaling pathways.

Go back
727.0, 923.0
25.0, 25.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041446

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c241 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 15481153 For example, in human DC TLR3 is able to induce IP-10 and IL-15 to similar levels as TLR4, yet it induces IFN-beta only very weakly.

Go back
1177.0, 109.0
30.0, 30.0

p96

p96

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016882

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 15481153, 11313410 DC maturation induced by LPS is a MyD88-independent response (Kaisho et al., 2001); however, it is also induced by TLR that cannot link to TRIF.

Go back
496.0, 924.0
23.0, 23.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e41

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 15481153, 12356687 For example, although both TLR2 and TLR9 exclusively activate the MyD88-dependent pathway, only TLR9 is able to induce IFN-beta production in mouse macrophages (Hoshino et al., 2002), thereby indicating the existence of differences between TLR2 and TLR9 that are not ascribable to the TRIF/IRF3 pathway.

Go back
746.0, 378.0
28.0, 28.0

p98

p98

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e16

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c256 : 1
stoichiometry:c236 : 1

m78*m16*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
799.0, 435.0
25.0, 25.0

p99

p99

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e110 e16

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c258 : 1

m112*m16*0.1

nodelay

--

true

0

false

PMID: 15481153 The fact that different TLR can induce such an array of responses suggest that they possess the ability to selectively activate distinct signaling pathways, which include the MAP kinases p38, c-Jun N-terminal kinase, ERK1/2, the transcription factors NF-kappaB and IRF-3, the PI3 kinase, and caspase-1.

Go back
1082.0, 239.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 375.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 232.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.0, 338.97086083237355

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.8289791386326, 224.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 250.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 334.0437687993774

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
428.9936076697743, 313.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 327.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 402.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 480.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 382.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1028.0, 450.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.1055682552917, 935.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 1028.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.4679769048231, 762.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.9383594873914, 762.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 834.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 842.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.0, 906.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 912.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.0, 387.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 388.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1020.0, 459.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.0, 242.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 242.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.1870748873536, 842.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 870.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.3750934133828, 912.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 946.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1085.0, 453.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 459.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 463.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
948.0, 834.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 463.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.50862842717, 839.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 840.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 870.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 906.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.2706363657628, 911.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 915.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
962.9967366916856, 944.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.2099278288765, 852.6887072379664

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1036.2988591893932, 924.2881772788919

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1033.0613012044826, 889.72987951681

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
204.0, 463.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0589763024298, 961.893816894603

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
927.9935216832996, 1073.3218867791932

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 1051.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 1068.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 1047.5249164408892

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 1105.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 1124.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 1097.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 1100.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 1156.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 429.4376015698018

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 1175.740986951436

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.5417010724733, 1037.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.9601774867889, 1089.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 1210.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 1227.8605857057737

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.9987028429207, 1094.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.6013081105565, 1042.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.0, 1087.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
987.0, 1129.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0, 1161.6175070101028

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 498.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 1167.5444971872405

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.0, 988.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 1028.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 1254.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 1242.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.9978177507485, 194.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.0005971990363, 193.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
587.5925894646998, 119.54551552278792

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.002645862125, 99.71465137684811

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 1018.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.0, 414.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 1053.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 1088.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
91.56323297859589, 144.00008007166417

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
76.0, 119.5

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
64.21484514253132, 99.6251544949348

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.0, 1240.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 1264.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.5704490479059, 1279.0647661725031

c177

c177

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
882.0, 1316.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 1316.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.0, 506.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.1554175279994, 1326.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 1331.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 1368.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.0, 1316.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 1316.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.145770236779, 1326.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
668.0, 1364.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.0, 1296.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 1365.53215208419

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 1265.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1004.0, 498.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0161459702864, 192.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.0, 1124.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
48.228240654874924, 83.62505918538898

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
489.0, 1352.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 1373.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.3618863656579, 1037.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
727.627813188447, 1377.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 1376.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.9999648562263, 1436.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.0, 1064.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1160.0, 239.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.9507641624433, 330.4359256893571

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0006011464226, 79.66115612558741

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.0, 1096.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.924154981225, 67.76211522523067

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0, 1128.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.0, 1160.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 1188.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0004618861127, 52.158681816635294

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
691.9984374262774, 39.79126904729776

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.0026990782766, 23.74881781645047

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
232.99565623931053, 1073.2635930628344

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
905.0, 331.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.0, 1032.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.9990386926185, 1028.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.0, 1136.151825073934

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.7888069193034, 1028.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.0, 992.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 995.1119090269775

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
478.0, 984.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 811.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
607.0, 951.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.4310835055999, 963.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.0, 220.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 220.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
627.9648381271818, 193.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.4090509434968, 972.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0, 977.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.9997839534064, 191.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
478.0, 216.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.0, 1076.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 1039.846660889655

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.00482973351126, 1082.0

c228

c228

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
467.0, 233.0

c229

c229

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
161.0, 287.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 233.0

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
469.0, 8.032515629057059

c231

c231

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
336.0, 1236.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.9932530560082, 1221.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
438.0, 1143.8446454055274

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.0, 392.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.6371403542615, 406.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 1021.780571392251

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1099.0, 1080.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.0, 1237.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
141.0, 307.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.9662808700979, 1029.0

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.0, 948.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 417.0

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1192.0909032218306, 146.9994835210944

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
421.0, 811.0

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 947.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
32.154600323872444, 556.2800509997132

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 1074.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.3963893630444, 1034.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
926.7671936640628, 1084.0

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
153.0, 291.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
798.0, 1152.2447832916628

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.0, 1159.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.0, 1208.2423130131262

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.0, 1216.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
147.9203259749844, 561.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.1006209709275, 577.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.8655098886119, 396.46073755074224

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 448.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.8784275570199, 460.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.9996975596846, 448.0695625874755

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
425.0, 150.11179645141283

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.0, 544.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.8623479330104, 556.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.5212200508581, 456.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.8446454055273, 996.5689290811055

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
464.0, 91.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 143.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.0, 415.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.509867769654, 205.64990554975276

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.76114000116263, 400.94028500029066

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.9990534224661, 415.1230623603456

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
141.0, 208.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
160.59702919282185, 249.50701963363122

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 243.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
233.04186301724673, 190.39912625816768

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
179.0, 171.24231301312616

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
237.0, 177.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.0, 247.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1162.0, 283.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 404.3632612873492

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 283.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.0, 252.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1161.0, 323.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 323.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1161.0, 371.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 252.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 371.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.2636750760036, 842.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
176.0, 846.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 884.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.8335884449154, 412.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.0, 529.5777087639997

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 519.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 526.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.0, 638.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 647.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 568.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 608.9520752608762

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.43526425198644, 531.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 598.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.0, 653.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 404.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.68756514823656, 652.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 730.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 774.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.0, 774.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.0, 775.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.0, 938.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.15541752799933, 935.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
191.0, 976.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 558.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.0, 567.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.9999380005968, 279.0314958189

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.0, 559.8675800814034

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 899.0769230769231

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.6920784972148, 902.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 818.785492236829

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.8161052203985, 822.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.4814312430932, 641.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1002.8400875312688, 641.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.0, 622.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.364654255002, 627.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.9960966086966, 620.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
965.0, 207.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.0, 674.228478191191

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.3974247877977, 679.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
995.8788379507258, 629.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.0, 726.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.2044130909167, 733.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.2394443073428, 638.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 778.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0343357322942, 784.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
987.9929776408934, 641.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 279.0394083888453

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.0, 330.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.9039768230127, 209.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 218.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 233.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 232.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.5553614023481, 210.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 224.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 359.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 226.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 282.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.5813190393827, 196.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back