1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15545925.csml convertedTime:2009.07.01.10:48

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Inhibition of toll-like receptor and cytokine signaling--a unifying theme inischemic tolerance.
Authors Kariko K, Weissman D, Welsh FA.
Affiliation Department of Neurosurgery, University of Pennsylvania School of Medicine,Philadelphia, Pennsylvania, USA. kariko@mail.med.upenn.edu
Abstract Cerebral ischemia triggers acute inflammation, which exacerbates primary braindamage. Activation of the innate immune system is an important component of thisinflammatory response. Inflammation occurs through the action of proinflammatorycytokines, such as TNF, IL-1 beta and IL-6, that alter blood flow and increasevascular permeability, thus leading to secondary ischemia and accumulation ofimmune cells in the brain. Production of these cytokines is initiated bysignaling through Toll-like receptors (TLRs) that recognize host-derivedmolecules released from injured tissues and cells. Recently, great strides havebeen made in understanding the regulation of the innate immune system,particularly the signaling mechanisms of TLRs. Negative feedback inhibitors ofTLRs and inflammatory cytokines have now been identified and characterized. Itis also evident that lipid rafts exist in membranes and play a role inreceptor-mediated inflammatory signaling events. In the present review, usingthis newly available large body of knowledge, we take a fresh look at studies ofischemic tolerance. Based on this analysis, we recognize a striking similaritybetween ischemic tolerance and endotoxin tolerance, an immune suppressive statecharacterized by hyporesponsiveness to lipopolysaccharide (LPS). In view of thisanalogy, and considering recent discoveries related to molecular mechanisms ofendotoxin tolerance, we postulate that inhibition of TLR and proinflammatorycytokine signaling contributes critically to ischemic tolerance in the brain andother organs. Ischemic tolerance is a protective mechanism induced by a varietyof preconditioning stimuli. Tolerance can be established with two temporalprofiles: (i) a rapid form in which the trigger induces tolerance to ischemiawithin minutes and (ii) a delayed form in which development of protection takesseveral hours or days and requires de-novo protein synthesis. The rapid form oftolerance is achieved by direct interference with membrane fluidity, causingdisruption of lipid rafts leading to inhibition of TLR/cytokine signalingpathways. In the delayed form of tolerance, the preconditioning stimulus firsttriggers the TLR/cytokine inflammatory pathways, leading not only toinflammation but also to simultaneous upregulation of feedback inhibitors ofinflammation. These inhibitors, which include signaling inhibitors, decoyreceptors, and anti-inflammatory cytokines, reduce the inflammatory response toa subsequent episode of ischemia. This novel interpretation of the molecularmechanism of ischemic tolerance highlights new avenues for future investigationinto the prevention and treatment of stroke and related diseases.
PMID 15545925
Model Abstract

Entity

G010220:GM-CSF G010229:IL-2 G010262:IL-6 G010389:IL-1beta G010453:IFN-gamma G010539:SOCS1 G010693:Tlr4 G011948:SOCS3 G012653:ZFP36 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000058:NF-kappaB MO000000092:EpoR MO000000204:TNF MO000000205:TNFR MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000007384:IL-6 MO000016573:MyD88 MO000016589:IL-1alpha MO000016596:IL-1RII MO000016597:IL-1beta MO000016601:sIL-1RII MO000016882:LPS MO000017004:SOCS-1 MO000017066:Epo MO000017121:SOCS-3 MO000017247:IL-10 MO000017252:IL-10R MO000017264:IL-8 MO000017265:IL-12 MO000018132:CD14 MO000018458:sIL-6R MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019420:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022224:dsRNA MO000039077:IRAK-4 MO000042012:TLR9 e1: e10: e11:CpG DNA:TLRs e12:Flagellin e13:TLRs:Flagellin e14:albumin e15:LPS:albumin e16:LPS:LBP e17:mindin e18:mindin:LPS e19:TLR4:MD2 e2: e20:LPS:TLR4:MD2 e21:TRAF6{active} e22:IKK-beta{active} e23:NF-kappaB{active} e24:MAP3K e25:MAP3K{active} e26:JNK{active} e27:ERK{active} e28:p38{active} e29:CpG DNA: TLR9 e3: e30:TNF e31:IL-12 e32:dsRNA:TLR3 e33:IL-10 e34:IL-10:IL-10R e35:IL-8 e36:IFN-gamma e37:IL-1alpha:IL-1RII e38:IL-1alpha:sIL-1RII e39:IL-1beta:IL-1RII e4: e40:IL-1beta:IL-1RII e41:sTNFR-55 e42:TNF:sTNFR-55 e43:sTNFR-75 e44:TNF:sTNFR-75 e45:IL-6:sIL-6R e46:sgp130 e47:IL-6:sgp130 e48:TNF:TNFR e49:TTP e5:dsRNA:TLRs e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CpG DNA e60: e61: e62: e63:TTP e64:TNF:TTP e65:IL-6:TTP e66:IL-2:TTP e67:GM-CSF:TTP e68:EPO:EPOR e69:PI3K{active} e7:LPS:TLR4:MD2:MYD88 e70:Halothane e71:ketamine e72:Isoflurane e73:PUFA e74:DHA e75:TLR2:TLR2 ligand e76:TLR2 ligand e77:TLR5 ligand e78:TLR5 ligand: TLR5 e8: e9:IRAK{p}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p34 p35 p4 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p9
Model Detail
889.0, 1513.0
30.0, 30.0

GM-CSF

--

G010220

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p61

true true true true

csml-variable:Double

m93209

10

false

infinite

0

unit false false false
TRANSFACG010220

--

Go back
1114.0, 1518.0
36.0, 36.0

IL-2

--

G010229

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m93218

10

false

infinite

0

unit false false false
TRANSFACG010229

--

Go back
590.0, 1534.0
36.0, 36.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p69

p59 p70

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
970.0, 1350.0
36.0, 36.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p27 p71

p26 p34 p73

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
951.0, 1479.0
42.0, 42.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41

p42

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
883.0, 1683.0
34.0, 34.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p63

p64

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
659.0, 1435.0
42.0, 42.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
974.0, 1674.0
36.0, 36.0

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p66

p65

true true true true

csml-variable:Double

m94757

10

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
1017.0, 1441.0
38.0, 38.0

ZFP36

--

G012653

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p51 p53

p54

true true true true

csml-variable:Double

m95342

10

false

infinite

0

unit false false false
TRANSFACG012653

--

Go back
1201.0, 365.0
30.0, 30.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
907.0, 375.0
34.0, 34.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1048.0, 380.0
32.0, 32.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1314.0, 358.0
28.0, 28.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1249.0, 1141.0
37.0, 37.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p72 p76 p77 p79 p81

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1444.0, 1600.0
40.0, 40.0

EpoR

--

MO000000092

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR003528
TRANSPATHMO000000092

--

Go back
88.0, 1252.0
32.0, 32.0

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p68

p47 p48 p52

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
309.0, 1377.0
46.0, 46.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
1320.0, 1104.0
32.0, 32.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
1313.0, 981.0
38.0, 38.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1377.0, 793.0
38.0, 38.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
221.0, 1425.0
38.0, 38.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p49 p50

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1394.0, 750.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
198.0, 126.0
44.0, 44.0

IL-1alpha

--

MO000016589

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p44

true true true true

csml-variable:Double

m1584

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016589

--

Go back
313.0, 213.0
38.0, 38.0

IL-1RII

--

MO000016596

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p46

true true true true

csml-variable:Double

m1590

10

false

infinite

0

unit false false false
InterProIPR004078
TRANSPATHMO000016596

--

Go back
1568.0, 1352.0
40.0, 40.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p34 p73

p45 p46

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
41.0, 249.0
29.0, 29.0

sIL-1RII

--

MO000016601

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p45

true true true true

csml-variable:Double

m1595

10

false

infinite

0

unit false false false
TRANSPATHMO000016601

--

Go back
1773.0, 393.0
38.0, 38.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5 p6

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1111.0, 1755.0
34.0, 34.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

--

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
1554.0, 1694.0
28.0, 28.0

Epo

--

MO000017066

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m1958

10

false

infinite

0

unit false false false
InterProIPR003013
TRANSPATHMO000017066

--

Go back
1307.0, 1619.0
34.0, 34.0

SOCS-3

--

MO000017121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65

--

true true true true

csml-variable:Double

m2005

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017121

--

Go back
175.0, 1171.0
42.0, 42.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p28

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
311.0, 1111.0
42.0, 42.0

IL-10R

--

MO000017252

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m2108

10

false

infinite

0

unit false false false
TRANSPATHMO000017252

--

Go back
210.0, 1626.0
36.0, 36.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p75

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
213.0, 1309.0
38.0, 38.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1441.0, 533.0
37.0, 37.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p7

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
47.0, 1459.0
34.0, 34.0

sIL-6R

--

MO000018458

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m3096

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000018458

--

Go back
1441.0, 653.0
38.0, 38.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p8

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1446.0, 206.0
36.0, 36.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
794.0, 138.0
52.0, 52.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1019.0, 143.0
50.0, 50.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
578.0, 142.0
44.0, 44.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1605.0, 397.0
30.0, 30.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p5

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1444.0, 580.0
40.0, 40.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p9

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
1511.0, 615.0
34.0, 34.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1691.0, 207.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p24

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1289.0, 809.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1284.0, 148.0
40.0, 40.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
287.7214131018621, 122.10197385173745
1224.2691494420865, 1828.5635926536715

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
286.01986318649665, 211.53148045298883
1139.972281661623, 1649.5600664887775

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1445.5, 319.8020171015128
29.55229116421837, 57.197982898487176

CpG DNA:TLRs

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1671.0, 116.68776413765346
49.9657878848863, 30.81223586234655

Flagellin

--

e12

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1425.5, 136.86735365051524
28.48520061390046, 55.13264634948476

TLRs:Flagellin

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1559.0, 338.57244918494666
42.04467699738378, 25.92755081505333

albumin

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1701.5, 334.1859690051658
29.248125312447936, 35.8140309948342

LPS:albumin

--

e15

cso30:c:Complex

cso30:i:CC_Extracellular

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1784.5, 473.19613397767034
30.056490584902527, 36.803866022329615

LPS:LBP

--

e16

cso30:c:Complex

cso30:i:CC_Extracellular

--

p5

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1444.5, 399.0605755685249
30.179311732743002, 48.939424431475146

mindin

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1448.5, 466.0
31.0, 60.0

mindin:LPS

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1692.5, 580.146475587402
31.73037827028828, 38.853524412597906

TLR4:MD2

--

e19

cso30:c:Complex

cso30:i:CC_Extracellular

--

p8

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
287.7214131018621, 122.10197385173745
1224.2691494420865, 1828.5635926536715

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1440.5, 706.3426316755368
30.571113965865298, 42.657368324463214

LPS:TLR4:MD2

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p10 p25 p51 p55 p56 p68 p69 p70 p71 p73 p74 p75 p76

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1381.0, 1045.0
38.0, 38.0

TRAF6{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p13 p15

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1376.0, 1224.0
32.0, 32.0

IKK-beta{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p14

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
1143.0, 1223.0
42.0, 42.0

NF-kappaB{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p72 p76 p77 p79 p81

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1322.0, 271.74
43.68, 32.76

MAP3K

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1162.0, 271.74
43.68, 32.76

MAP3K{active}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15

p16 p17 p18

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1048.0, 496.0
32.0, 32.0

JNK{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1161.0, 517.0
30.0, 30.0

ERK{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
902.0, 510.0
35.0, 35.0

p38{active}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1164.5, 138.0
31.0, 60.0

CpG DNA: TLR9

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20 p21 p22 p23 p77

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
312.2067960907038, 147.2888001968294
1175.298383464404, 1778.1899399634904

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
762.0, 1284.0
60.0, 32.0

TNF

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p20 p31 p55

p21 p58 p68

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
886.0, 1300.0
60.0, 32.0

IL-12

--

e31

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p22 p35

p23

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
936.5, 138.0
31.0, 60.0

dsRNA:TLR3

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p26 p27 p72

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
662.0, 1364.0
60.0, 32.0

IL-10

--

e33

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
316.5, 986.0
31.0, 60.0

IL-10:IL-10R

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p23 p27 p29 p30 p31 p34 p35 p41 p42 p68 p69 p70 p74 p75

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
786.0, 1500.0
60.0, 32.0

IL-8

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p56 p74

p75

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1568.0, 1481.9
48.8, 36.6

IFN-gamma

--

e36

cso30:c:Protein

cso30:i:CC_Extracellular

--

p42

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
316.5, 290.0
31.0, 60.0

IL-1alpha:IL-1RII

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
70.0, 163.55801104972375
36.39779005524862, 40.44198895027625

IL-1alpha:sIL-1RII

--

e38

cso30:c:Complex

cso30:i:CC_Extracellular

--

p44

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
78.0, 443.4475138121548
36.49723756906078, 40.55248618784531

IL-1beta:IL-1RII

--

e39

cso30:c:Complex

cso30:i:CC_Extracellular

--

p45

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
357.50475462006114, 191.36574630074
1084.7024664056878, 1690.0360477556687

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
316.5, 362.0
31.0, 60.0

IL-1beta:IL-1RII

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p46

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
52.0, 1105.3035822097
47.34554236264842, 29.19641779029986

sTNFR-55

--

e41

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p47

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
146.5, 1090.1973004499243
35.77220463256124, 43.802699550075

TNF:sTNFR-55

--

e42

cso30:c:Complex

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
152.5, 1297.2539746427854
23.276715636949085, 37.746025357214734

sTNFR-75

--

e43

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p48

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
83.0, 1392.4364640883975
34.707182320441994, 38.563535911602216

TNF:sTNFR-75

--

e44

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
141.5, 1526.4359273454422
29.043992667888684, 35.56407265455757

IL-6:sIL-6R

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
37.0, 1575.5060804490176
21.01403180542563, 48.49391955098223

sgp130

--

e46

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p50

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
107.0, 1620.4364640883978
34.707182320441994, 38.56353591160221

IL-6:sgp130

--

e47

cso30:c:Complex

cso30:i:CC_Extracellular

--

p50

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
312.5, 1430.0
31.0, 60.0

TNF:TNFR

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

p53

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1346.0, 1458.9000000000003
44.79999999999999, 33.6

TTP

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p54

p55 p56 p57

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1446.5, 253.31440473580358
27.737557553168166, 53.68559526419645

dsRNA:TLRs

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p67

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
555.0358467794395, 1172.7439898490943
632.9933560782266, 590.5006413053176

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
623.4038442701977, 1186.737996595125
370.130193312036, 572.3127365423203

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
563.2871568214277, 1180.6254152463935
616.490735994251, 574.7377905107201

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
564.4659153988546, 1181.8379422305918
614.133218839397, 572.3127365423203

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
555.0358467794395, 1172.7439898490943
632.9933560782266, 590.5006413053176

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
555.0358467794395, 1172.7439898490943
632.9933560782266, 590.5006413053176

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
564.4659153988546, 1181.8379422305918
614.133218839397, 572.3127365423203

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1017.1092091307705, 1415.2493866890604
39.54594690319391, 36.825052213521374

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
913.3784543172064, 1585.0031644770359
111.98206485555221, 104.27732064118561

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
555.0358467794395, 1172.7439898490943
632.9933560782266, 590.5006413053176

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1742.0, 201.5
60.0, 21.0

CpG DNA

--

e6

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p2 p19

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
704.2288191986135, 1435.1575954982106
20.045969500960513, 9.928261324706584

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
703.5594275352245, 1405.5491708154627
68.6126454973939, 127.04079892946521

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
732.3432690609609, 1488.1773327208061
10.710266614227335, 11.01708825404576

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1033.0, 1561.7000000000003
38.39999999999999, 28.799999999999997

TTP

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57

p58 p59 p60 p61

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
945.0, 1591.5017301038065
45.93425605536332, 24.498269896193772

TNF:TTP

--

e64

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p58

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
665.0, 1615.5017301038065
45.93425605536332, 24.498269896193772

IL-6:TTP

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1077.0, 1603.5017301038065
45.93425605536332, 24.498269896193772

IL-2:TTP

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p60

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
797.0, 1599.5017301038065
45.93425605536332, 24.498269896193772

GM-CSF:TTP

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1448.5, 1674.0
31.0, 60.0

EPO:EPOR

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p62

p63 p64 p65 p66

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1324.0, 532.0
40.0, 40.0

PI3K{active}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p67

--

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1446.0, 786.0
36.0, 60.0

LPS:TLR4:MD2:MYD88

--

e7

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
622.0, 951.0
60.0, 34.0

Halothane

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p55 p68 p69 p70

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
826.0, 955.0
60.0, 34.0

ketamine

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p55 p68 p69 p70

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
466.0, 951.0
60.0, 34.0

Isoflurane

--

e72

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p14 p55 p68 p69 p70

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
630.0, 1743.0
60.0, 34.0

PUFA

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p55 p68 p69 p70 p71 p73 p74 p75

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
686.0, 827.0
60.0, 34.0

DHA

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p72 p76 p77 p79 p81

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
688.5, 138.0
31.0, 60.0

TLR2:TLR2 ligand

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p79

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
834.0, 57.484182776801404
44.63971880492092, 29.015817223198592

TLR2 ligand

--

e76

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p78

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
630.0, 58.14674868189806
43.62038664323374, 28.353251318101933

TLR5 ligand

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p80

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
480.5, 134.0
31.0, 60.0

TLR5 ligand: TLR5

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

p81

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
487.0550996116854, 130.77429931512742
810.287810159118, 1210.2426904273848

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1381.0, 913.0
38.0, 38.0

IRAK{p}

--

e9

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p12

true true true true

csml-variable:Double

m9

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1552.0, 212.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 MO000022224

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3962*m119368*0.1

nodelay

--

true

0

false

PMID: 15545925, 12606705 There are at least 10 distinct TLR family members in humans, and corresponding ligands for most ofthem have been identified. These ligands include bacterial and viral constituents, such as unmethylated CpGDNA, double-stranded RNA (dsRNA), LPS, and flagellin.

Go back
1570.0, 730.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000016573

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c32 : 1

m20*m1572*0.1

nodelay

--

true

0

false

PMID: 15545925 During intracellular signal transduction, the TIR domain of the TLR associates with an intracellular adaptor protein MyD88.

Go back
1344.0, 864.0
23.0, 23.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000213 e7 MO000039077

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c34 : 1

m184*m7*m17258*0.1

nodelay

--

true

0

false

PMID: 15545925 Phosphorylation of IRAK, a serine-threonine kinase, by other IRAK family members induces cascades of signaling through TRAF6 (tumor necrosis factor receptor-associated factor 6).

Go back
1388.0, 988.0
23.0, 23.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000212 e9

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m183*m9*0.1

nodelay

--

true

0

false

PMID: 15545925 Phosphorylation of IRAK, a serine-threonine kinase, by other IRAK family members induces cascades of signaling through TRAF6 (tumor necrosis factor receptor-associated factor 6).

Go back
1381.0, 1161.5
21.5, 21.5

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000211 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m182*m21*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta(IkappaB beta kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines.

Go back
1256.0, 1232.0
23.0, 23.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e22 e72

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c209 : 1
stoichiometry:c44 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta(IkappaB beta kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines. PMID: 15545925, 15041589 Activation of NF-kappaB;B was significantly inhibited by isoflurane.

Go back
1252.0, 276.5
23.5, 23.5

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 e21

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m25*m21*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta (IkappaB kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines.

Go back
914.0, 449.5
20.5, 20.5

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e25

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c56 : 1
stoichiometry:c54 : 1

m31*m26*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta (IkappaB kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines.

Go back
1054.0, 446.5
19.5, 19.5

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c55 : 1
stoichiometry:c52 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta (IkappaB kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines.

Go back
1165.0, 445.0
21.0, 21.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e25

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c57 : 1
stoichiometry:c50 : 1

m29*m26*0.1

nodelay

--

true

0

false

PMID: 15545925 TRAF6 transduces the signal to IKK beta (IkappaB kinase) and to MAP3K (mitogen-activated protein kinase kinase kinase). Thissignaling results in transcriptional responses, mediated primarily by nuclear factor-kappaB (NF-kappaB), extracellular-signal regulated kinase(ERK) and stress-activated protein kinases, such as c-Jun N-terminal kinase (JNK) and p38, leads to expression of proinflammatory cytokines.

Go back
1292.0, 88.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000042012

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m6*m19828*0.1

nodelay

--

true

0

false

PMID: 15545925, 11994434 Microglia, which express TLR9, release TNF and IL-12 when stimulated with non-methylated CpG DNA.

Go back
1584.0, 284.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3962*m6*0.1

nodelay

--

true

0

false

PMID: 15545925, 12606705 There are at least 10 distinct TLR family members in humans, and corresponding ligands for most ofthem have been identified. These ligands include bacterial and viral constituents, such as unmethylated CpGDNA, double-stranded RNA (dsRNA), LPS, and flagellin.

Go back
804.0, 1236.0
24.0, 24.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c61 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15545925, 11994434 Microglia, which express TLR9, release TNF and IL-12 when stimulated with non-methylated CpG DNA.

Go back
598.0, 1254.0
27.0, 27.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30 e29

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c69 : 1
stoichiometry:c63 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 15545925, 11994434 Microglia, which express TLR9, release TNF and IL-12 when stimulated with non-methylated CpG DNA.

Go back
903.0, 1231.0
26.0, 26.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c64 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 15545925, 11994434 Microglia, which express TLR9, release TNF and IL-12 when stimulated with non-methylated CpG DNA.

Go back
530.0, 1286.0
27.0, 27.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e31 e29 e34

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c70 : 1
stoichiometry:c92 : 1
stoichiometry:c66 : 1

m35*m33*0.1

nodelay

--

true

0

false

PMID: 15545925, 11994434 Microglia, which express TLR9, release TNF and IL-12 when stimulated with non-methylated CpG DNA. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1080.0, 76.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 15545925, 12951652 Chronic glial activation, neurodegeneration and IL-1beta induction in arat brain has been demonstrated after administration of dsRNA, the ligand of TLR3.

Go back
474.0, 1178.0
27.0, 27.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33 e20

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m37*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11008976 IL-10, secreted as a feedback inhibitor during inflammation initiated by LPS or tissue damage.

Go back
1252.0, 1360.0
23.0, 23.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e32

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c78 : 1
stoichiometry:c75 : 1

m93364*m36*0.1

nodelay

--

true

0

false

PMID: 15545925, 12951652 Chronic glial activation, neurodegeneration and IL-1beta induction in arat brain has been demonstrated after administration of dsRNA, the ligand of TLR3.

Go back
994.0, 1294.0
27.0, 27.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e32 e34

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c106 : 1
stoichiometry:c76 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 15545925, 12951652 Chronic glial activation, neurodegeneration and IL-1beta induction in arat brain has been demonstrated after administration of dsRNA, the ligand of TLR3. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
221.0, 1101.0
21.0, 21.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017247 MO000017252

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m2103*m2108*0.1

nodelay

--

true

0

false

Go back
596.0, 1444.0
24.0, 24.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c85 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15545925, 10820283 The most important anti-inflammatory effects of IL-10 is downregulation of expression of TLR4.

Go back
1594.0, 122.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3962*m12*0.1

nodelay

--

true

0

false

PMID: 15545925, 12606705 There are at least 10 distinct TLR family members in humans, and corresponding ligands for most ofthem have been identified. These ligands include bacterial and viral constituents, such as unmethylated CpGDNA, double-stranded RNA (dsRNA), LPS, and flagellin.

Go back
791.0, 647.0
26.0, 26.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010693 e34

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c86 : 1

m93614*0.1

nodelay

--

true

0

false

PMID: 15545925, 10820283 The most important anti-inflammatory effects of IL-10 is downregulation of expression of TLR4.

Go back
769.0, 1249.5
21.5, 21.5

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c90 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1326.0, 1290.0
27.0, 27.0

p34

p34

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e34

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c96 : 1

m93364*0.1

nodelay

--

true

0

false

PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
866.0, 1198.0
27.0, 27.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c101 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1642.0, 341.5
20.5, 20.5

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000016882

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m155666*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
856.0, 1388.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c115 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1268.0, 1488.0
23.0, 23.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010453 e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m93423*0.1

nodelay

--

true

0

false

PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
208.0, 220.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016589 MO000016596

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m1584*m1590*0.1

nodelay

--

true

0

false

PMID: 15545925 IL-1RII is a non-signaling receptor, which exists in membrane-associated and soluble forms. Both forms of the receptor bind and reduce the bioavailability of IL-1alpha and IL-1beta.

Go back
124.0, 252.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016601 MO000016589

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m1595*m1584*0.1

nodelay

--

true

0

false

PMID: 15545925 IL-1RII is a non-signaling receptor, which exists in membrane-associated and soluble forms. Both forms of the receptor bind and reduce the bioavailability of IL-1alpha and IL-1beta.

Go back
211.0, 451.0
25.0, 25.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016601 MO000016597

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m1595*m1591*0.1

nodelay

--

true

0

false

PMID: 15545925 IL-1RII is a non-signaling receptor, which exists in membrane-associated and soluble forms. Both forms of the receptor bind and reduce the bioavailability of IL-1alpha and IL-1beta.

Go back
223.0, 379.5
25.5, 25.5

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016596 MO000016597

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m1590*m1591*0.1

nodelay

--

true

0

false

PMID: 15545925 IL-1RII is a non-signaling receptor, which exists in membrane-associated and soluble forms. Both forms of the receptor bind and reduce the bioavailability of IL-1alpha and IL-1beta.

Go back
65.0, 1185.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000000204

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m45*m175*0.1

nodelay

--

true

0

false

PMID: 15545925 Decoy receptors such as sTNFR-55, sTNFR-75, IL-1RII, sIL-6R, and sgp130 bind, inactivate, and promote clearance of their corresponding ligands thereby limiting immune activation.

Go back
89.0, 1317.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000204 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m175*m47*0.1

nodelay

--

true

0

false

PMID: 15545925 Decoy receptors such as sTNFR-55, sTNFR-75, IL-1RII, sIL-6R, and sgp130 bind, inactivate, and promote clearance of their corresponding ligands thereby limiting immune activation.

Go back
147.0, 1467.0
17.0, 17.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000007384 MO000018458

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m871*m3096*0.1

nodelay

--

true

0

false

PMID: 15545925 Decoy receptors such as sTNFR-55, sTNFR-75, IL-1RII, sIL-6R, and sgp130 bind, inactivate, and promote clearance of their corresponding ligands thereby limiting immune activation.

Go back
1680.0, 400.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019420 MO000016882

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
217.0, 1529.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000007384 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m871*m63*0.1

nodelay

--

true

0

false

PMID: 15545925 Decoy receptors such as sTNFR-55, sTNFR-75, IL-1RII, sIL-6R, and sgp130 bind, inactivate, and promote clearance of their corresponding ligands thereby limiting immune activation.

Go back
899.0, 1363.0
26.0, 26.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G012653

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c144 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499 Resting macrophages do not express TTP, but in response to LPS or TNF stimulation TTP mRNA was detected within 15 min.

Go back
186.0, 1370.0
19.0, 19.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000205 MO000000204

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c150 : 1

m176*m175*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499 Resting macrophages do not express TTP, but in response to LPS or TNF stimulation TTP mRNA was detected within 15 min.

Go back
928.0, 1424.0
23.0, 23.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e48

G012653

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499 Resting macrophages do not express TTP, but in response to LPS or TNF stimulation TTP mRNA was detected within 15 min.

Go back
1240.0, 1440.0
23.0, 23.0

p54

p54

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G012653

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m95342*0.1

nodelay

--

true

0

false

Go back
844.0, 1244.0
23.0, 23.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e20 e49 e70 e71 e72 e73

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c189 : 1
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c226 : 1
stoichiometry:c153 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11435226 TTP also suppresses LPS-induced transcription of TNF and the chemokine IL-8. PMID: 15545925, 11112152, 12502984, 11605934 Halothane, isoflurane, and ketamine all rapidly induce endotoxin tolerance, measured as a reduction in the level of TNF and IL-6 secretion following an in vivo LPS challenge. PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells.

Go back
840.0, 1460.0
23.0, 23.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e49

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c156 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11435226 TTP also suppresses LPS-induced transcription of TNF and the chemokine IL-8.

Go back
1228.0, 1564.0
23.0, 23.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499, 12748283, 11720287, 12324455 TTP (Tristetraprolin) is a proline-rich protein, that binds to AU-rich elements present in the 3prime-untranslated regions of mRNAs encoding proinflammatory cytokines,such as TNF, IL-2, IL-6, and GM-CSF.

Go back
958.0, 1534.5
19.5, 19.5

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e63 e30

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m67*m34*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499, 12748283, 11720287, 12324455 TTP (Tristetraprolin) is a proline-rich protein, that binds to AU-rich elements present in the 3prime-untranslated regions of mRNAs encoding proinflammatory cytokines,such as TNF, IL-2, IL-6, and GM-CSF.

Go back
676.0, 1564.0
23.0, 23.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

G010262 e63

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m93248*m67*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499, 12748283, 11720287, 12324455 TTP (Tristetraprolin) is a proline-rich protein, that binds to AU-rich elements present in the 3prime-untranslated regions of mRNAs encoding proinflammatory cytokines,such as TNF, IL-2, IL-6, and GM-CSF.

Go back
1643.0, 431.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000016882

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m17*m155666*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
1054.0, 1526.0
19.0, 19.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e63 G010229

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m67*m93218*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499, 12748283, 11720287, 12324455 TTP (Tristetraprolin) is a proline-rich protein, that binds to AU-rich elements present in the 3prime-untranslated regions of mRNAs encoding proinflammatory cytokines,such as TNF, IL-2, IL-6, and GM-CSF.

Go back
809.0, 1545.5
21.5, 21.5

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

G010220 e63

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m93209*m67*0.1

nodelay

--

true

0

false

PMID: 15545925, 9703499, 12748283, 11720287, 12324455 TTP (Tristetraprolin) is a proline-rich protein, that binds to AU-rich elements present in the 3prime-untranslated regions of mRNAs encoding proinflammatory cytokines,such as TNF, IL-2, IL-6, and GM-CSF.

Go back
1556.0, 1608.0
23.0, 23.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000092 MO000017066

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m82*m1958*0.1

nodelay

--

true

0

false

PMID: 15545925, 11696536 EPO, for example, induces SOCS1 and SOCS3 production.

Go back
885.0, 1637.5
21.5, 21.5

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e68

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15545925, 11696536 EPO, for example, induces SOCS1 and SOCS3 production.

Go back
995.0, 1759.0
25.0, 25.0

p64

p64

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010539 e68

MO000017004

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c180 : 1
stoichiometry:c179 : 1

m93501*m72*0.1

nodelay

--

true

0

false

PMID: 15545925, 11696536 EPO, for example, induces SOCS1 and SOCS3 production.

Go back
1206.0, 1626.0
19.0, 19.0

p65

p65

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011948 e68

MO000017121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m94757*m72*0.1

nodelay

--

true

0

false

PMID: 15545925, 11696536 EPO, for example, induces SOCS1 and SOCS3 production.

Go back
1016.0, 1624.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e68

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15545925, 11696536 EPO, for example, induces SOCS1 and SOCS3 production.

Go back
1324.0, 444.0
23.0, 23.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 e5

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m73*m5*0.1

nodelay

--

true

0

false

PMID: 15545925, 11563964, 12052830 Stimulation of TLRs activates PI3K, leading to the inhibition of expression of many inflammatory genes through diverse mechanisms.

Go back
679.0, 1167.0
25.0, 25.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e30 e70 e20 e71 e72 e73 e34

MO000000204

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c196 : 1
stoichiometry:c227 : 1
stoichiometry:c88 : 1
stoichiometry:c191 : 1

m34*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11112152, 12502984, 11605934 Halothane, isoflurane, and ketamine all rapidly induce endotoxin tolerance, measured as a reduction in the level of TNF and IL-6 secretion following an in vivo LPS challenge. PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
643.0, 1499.0
25.0, 25.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e71 e70 e72 e73 e34

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c224 : 1
stoichiometry:c254 : 1
stoichiometry:c205 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11112152, 12502984, 11605934 Halothane, isoflurane, and ketamine all rapidly induce endotoxin tolerance, measured as a reduction in the level of TNF and IL-6 secretion following an in vivo LPS challenge. PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1676.0, 479.5
24.5, 24.5

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000018132 e16

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m2828*m16*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
494.0, 1502.0
19.0, 19.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e72 e70 e71 e20 e73 e34

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c225 : 1
stoichiometry:c95 : 1
stoichiometry:c199 : 1

m93248*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 11112152, 12502984, 11605934 Halothane, isoflurane, and ketamine all rapidly induce endotoxin tolerance, measured as a reduction in the level of TNF and IL-6 secretion following an in vivo LPS challenge. PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1079.0, 1291.0
25.0, 25.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e73

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c222 : 1
stoichiometry:c210 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells.

Go back
1153.0, 1149.0
21.0, 21.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e32 e74

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c229 : 1

m23*m36*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1173.0, 1297.0
21.0, 21.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e20 e73

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c214 : 1
stoichiometry:c223 : 1
stoichiometry:c213 : 1

m93364*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells.

Go back
764.0, 1412.0
23.0, 23.0

p74

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e73 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c221 : 1
stoichiometry:c105 : 1
stoichiometry:c215 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
529.0, 1677.0
21.0, 21.0

p75

p75

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e35 e20 e73 e34

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c98 : 1
stoichiometry:c217 : 1

m39*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 7524649, 2783477, 11998897 PUFA, belonging either to the omega-3 or omega-6 family, inhibits LPS-induced and cytokine-induced inflammation by suppressing the secretion of inflammatory mediators (TNF, IL-1beta, IL-6, IL-8, etc.) both in patients and in cultured cells. PMID: 15545925, 11244051 The most important anti-inflammatory effects of IL-10 is inhibition of production of all inflammatory cytokines, including IL-1beta, TNF, IL-6, IL-8, IFN-gamma, and IL-12.

Go back
1204.0, 1072.0
23.0, 23.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e20 e74

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c233 : 1

m23*m20*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1086.0, 970.0
19.0, 19.0

p77

p77

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e29 e74

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c237 : 1

m23*m33*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
739.0, 59.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e76 MO000019397

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m81*m3964*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1015.0, 1023.0
25.0, 25.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e75 e74

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c244 : 1

m23*m80*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1582.0, 662.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
572.0, 64.0
23.0, 23.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e77 MO000019399

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c249 : 1

m83*m3966*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1183.0, 907.0
25.0, 25.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e74 e78

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c251 : 1

m23*m84*0.1

nodelay

--

true

0

false

PMID: 15545925, 12865424, 14966134 Treatment with docosahexaenoic acid (DHA), the most unsaturated fatty acid present in the mammalian membrane, inhibited NF-kappaB activation in response to TLR2-, TLR3-, TLR4-, TLR5- and TLR9-mediated stimulation by their corresponding ligands.

Go back
1610.0, 590.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e19 MO000021929

e20 MO000018132 MO000019420

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m19*m6255*0.1

nodelay

--

true

0

false

PMID: 15545925, 12372833, 14691481 Optimal signal transduction through TLR4 requires binding of LPS to serum proteins, such as albumin, LPS-binding protein, and MD2, as well as cell surface-associated molecules,such as mindin and the GPI-(glycosylphosphatidylinositol)linked CD14.

Go back
1482.0, 224.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1601.0, 352.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.0, 1225.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 1022.0

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 1030.0

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 1023.0

c106

c106

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 1041.0

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1670.3566150334823, 360.14328096885146

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.0, 1411.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 1027.0

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
993.0, 1500.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1291.0, 1500.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 1024.0

c119

c119

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1663.0, 352.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 170.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
239.0, 232.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 241.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
70.0, 264.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.6723513590001, 170.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.13692511940465, 210.84732433556633

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
68.0, 278.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.658708699869, 476.43414010269055

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
122.0, 464.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.1002933856581, 251.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1635.0, 412.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.47752526820673, 405.69485531190725

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 392.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
76.0, 1134.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.9151947886441, 1213.449942237646

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
86.0, 1134.5124930288468

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.48396048321513, 1284.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
117.86504039586868, 1318.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.0, 1338.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
171.46338504034063, 1451.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
81.0, 1476.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1711.0, 412.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.0, 1484.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.08090563786652, 1463.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
58.0, 1546.5298221281348

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.76958130522837, 1550.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 1385.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.1439062969927, 746.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
212.90697358120494, 1382.2164574740316

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
117.0, 1284.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.0, 1439.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 1436.3148244311863

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1703.0, 420.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 1385.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.0, 1452.3024862450739

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1263.0, 1454.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.5857022873224, 1264.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0115218004042, 742.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
870.6745932268636, 1262.5803052290896

c155

c155

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
834.0856580228888, 1483.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0431012917923, 747.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.9998628381361, 1472.0331251580799

c158

c158

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1257.3360815775754, 1493.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1475.0, 426.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.0, 1576.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.4737470894349, 1550.853612525057

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 1316.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 1554.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 1558.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.0, 1576.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 1587.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.0, 1552.6749240125703

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 1536.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 1545.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1675.782449717483, 416.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.5629838530102, 1533.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.9718190527359, 1557.670895662854

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 1567.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1484.0, 1620.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1568.0, 1639.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1486.198920166175, 1630.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 1659.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.9620237436466, 1649.7785742775152

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.0, 1711.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1020.0, 1772.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1487.7235518911393, 448.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.9124353015275, 1706.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1046.904279964492, 1639.2338388237256

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1008.2625061574892, 1647.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0, 1639.9402850002907

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1225.0, 1636.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.7101125073484, 1640.1340489975696

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1329.0, 386.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1337.0, 467.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1348.6328704548532, 299.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 985.0

c189

c189

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1478.0, 497.0320990041109

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
707.1345814735881, 1198.1348246177936

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.91117912902031, 1182.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 985.0

c192

c192

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
710.8853654650744, 737.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
704.4837140436053, 989.0

c194

c194

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
856.0, 989.0

c195

c195

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
512.0, 985.0

c196

c196

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
517.0, 985.0

c197

c197

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
520.4542191358826, 1517.9042412217725

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
266.7513416849957, 1450.9790659621265

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1583.0, 224.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1709.0, 492.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 985.0

c200

c200

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
508.0455169515274, 985.0

c201

c201

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
513.1824792533968, 989.0

c202

c202

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
519.1762102728785, 741.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
673.7156983704019, 743.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.1754418849364, 1523.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
662.3899759792146, 989.0

c206

c206

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
652.0, 985.0

c207

c207

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
501.0, 985.0

c208

c208

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
526.0, 979.0

c209

c209

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1491.214528229797, 498.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.8100615064012, 1312.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.2780425689914, 749.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 1313.3365842820067

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.0, 1310.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.3968254774056, 749.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.0, 1435.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.7839864320407, 1532.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
253.925099683877, 1648.0921515465413

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.5923581503843, 744.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.5220368947898, 744.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1479.0, 672.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.4336609321919, 1696.0518217765537

c220

c220

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
666.0, 1438.7822742486485

c221

c221

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
676.0, 1318.9022028385737

c222

c222

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
680.0, 1319.6152785697755

c223

c223

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
656.0730471773172, 1527.9993329581177

c224

c224

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
512.1227405063946, 1524.3902762044577

c225

c225

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
667.0, 1270.728312594111

c226

c226

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
661.0, 1195.9940843149477

c227

c227

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1182.0, 1160.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 1170.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1545.0, 643.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
958.0, 198.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.0, 861.0

c231

c231

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1228.4708276965785, 1101.6341314207293

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.440365410742, 1095.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.4754302446463, 749.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 858.0

c235

c235

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1110.5219942005222, 994.7885732308921

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 989.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1097.8245998661823, 198.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 855.0

c239

c239

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1601.0, 614.159575575166

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 72.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.7618204050059, 90.42845754675797

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.5777087639997, 84.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.1071761128605, 1045.6726077521

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 1048.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.0, 198.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 861.0

c246

c246

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
602.9869706753918, 73.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.4310835055999, 94.87095928079925

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.6106781396767, 87.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1637.0, 600.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.275205420488, 939.669644078742

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1166.7933212007947, 932.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 849.0

c252

c252

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
512.0, 181.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 1040.0

c254

c254

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1484.0, 600.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1477.317264152115, 608.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1471.0, 729.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1422.0, 742.1238778247473

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1481.0437687993774, 230.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1485.6561952354677, 559.320059162263

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1620.0, 435.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1488.7145134043678, 747.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1367.2950039375453, 831.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1365.0, 887.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1373.9890810908382, 826.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1319.0, 839.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1351.0, 1000.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1400.0, 1011.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1400.0, 951.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1482.0, 234.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1352.0, 1135.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1392.0, 1183.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1393.6058500848515, 1083.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1268.0, 1178.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1193.0, 1244.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.9961766187446, 1241.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1284.0, 288.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1214.0, 288.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1267.3854557802501, 307.8791187502773

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1185.690821893136, 395.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1614.2247508391579, 223.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 466.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 412.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 466.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 409.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.3995009355511, 470.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.6368678424956, 305.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
941.6744410670501, 303.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.3425427071375, 305.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1322.7810789392597, 104.85871206511592

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1304.0, 119.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1482.4878065358803, 301.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1203.0035571597448, 107.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.3332376839458, 1260.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.8700385288315, 1271.43613841767

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
128.0, 1268.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 1257.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.992766725465, 1301.3401177329986

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
258.968075367718, 1301.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.556098244679, 198.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.9101887138435, 198.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.67428487748, 198.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1482.0, 143.36831672551102

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.921482453096, 196.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1059.0, 105.88741222571453

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.8113673995092, 91.72700299649011

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
974.9459451369956, 95.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 1368.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1275.0, 1372.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.6079254665552, 1321.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 198.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.0, 198.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.8887969655509, 1209.4149857154491

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1621.0, 132.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.0, 1192.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.212783039031, 735.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
205.0, 1129.2981562686757

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.84024471299028, 1115.5907742895922

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
242.0, 1036.4998082233071

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1456.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 660.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.0, 680.904195128939

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 1023.0

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 672.4080673150524

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1461.8552500606081, 134.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 1271.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 1024.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 1037.0

c92

c92

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
342.0, 1046.0

c95

c95

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1353.0, 1308.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 1308.4267538292097

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
341.0, 1046.0

c98

c98

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 1020.0

c99

c99

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back