1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15576198.csml convertedTime:2009.07.01.10:49

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate immune responses during infection.
Authors Ulevitch RJ, Mathison JC, da Silva Correia J.
Affiliation Department of Immunology, The Scripps Research Institute, 10550 North TorreyPines Road, La Jolla, CA 92037, USA.
Abstract The innate immune system senses bacteria in the environment and defends againstinfection. Here we will discuss two types of sensor protein families. The plasmamembrane receptors that comprise the Toll-like receptor (TLRs) family and theintracellular proteins termed NOD1 and NOD2. These proteins directly bindbacterial products such as lipopolysaccharides (LPS), peptidoglycan fragments,bacterial DNA, and receptor binding leads to intracellular signaling and geneexpression. TLR signaling involves members of the MyD88 family of adaptorproteins. In contrast NOD1 or NOD2 utilize pathways that do not depend on theMyD88 family members.
PMID 15576198
Model Abstract

Entity

MO000000058:NF-kappaB MO000000212:TRAF6 MO000016573:MyD88 MO000016882:LPS MO000017949:RIP2 MO000019396:TLR1 MO000019397:TLR2 MO000019399:TLR5 MO000019422:TLR6 MO000020434:Nod1 MO000020461:Nod2 MO000022185:flagellin MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 e1: e10: e11:TLR2:TLR1 e12:TLR2: TLR6 e13:diacylated lipopeptides e14:diacylated lipoproteins: TLR2: TLR1 e15:triacylated lipoproteins: TLR2: TLR6 e16:triacylated lipoproteins e17:CpG DNA e18:CpG DNA: TLR9 e19:loxoribine e2: e20:imadazole quinoline e21:loxoribine: TLR7 e22:imadazole quinoline: TLR8 e23:flagellin: TLR9 e24:LPS:CD14: TLR4: MD-2: MyD88 e25:Mal e26:LPS:CD14: TLR4: MD-2: MyD88: TIRAP: Mal e27:LPS:CD14: TLR4: MD-2: TRIF e28:IRAK-4 {activated} e29:TRAF6 e3: e30:NF-kappaB {activated} e31:PGN: Nod1 e32:PGN: Nod2 e4: e5:CD14: TLR4: MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:CD14: TLR4: MD-2 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
429.0, 505.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p18 p19

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
502.0, 346.0
44.0, 44.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
260.0, 304.0
40.0, 40.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
68.0, 68.0
40.0, 40.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
622.0, 590.0
35.0, 35.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
653.0, 157.0
37.0, 37.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
704.0, 164.0
31.0, 31.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
133.0, 533.0
38.0, 38.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
749.0, 161.0
37.5, 37.5

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
840.0, 448.0
39.0, 39.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
839.0, 703.0
42.0, 42.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
51.0, 523.0
42.0, 42.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
337.0, 305.0
38.0, 38.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
503.0, 219.0
41.5, 41.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
319.0, 359.0
41.0, 41.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
924.0, 308.0
39.0, 39.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
232.0, 528.0
40.0, 40.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1011.0, 575.0
42.0, 42.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
921.0, 193.0
38.0, 38.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
119.75, 149.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
128.0, 169.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
597.0, 161.0
37.0, 37.0

TLR2:TLR1

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p4

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000042221

--

Go back
803.5, 154.0
32.539746427852684, 52.76715636949084

TLR2: TLR6

--

e12

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p5

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
596.0, 23.5
39.718804920913875, 25.817223198594025

diacylated lipopeptides

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
516.0, 140.5
63.52, 47.64

diacylated lipoproteins: TLR2: TLR1

--

e14

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
855.0, 141.5
58.72, 44.03999999999999

triacylated lipoproteins: TLR2: TLR6

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
935.0, 78.5
42.24956063268893, 27.462214411247803

triacylated lipoproteins

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
42.0, 473.5
60.0, 21.0

CpG DNA

--

e17

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
212.0, 464.5
64.55222378748239, 39.80720466894747

CpG DNA: TLR9

--

e18

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1000.0, 166.0
48.24222035323801, 27.33725820016821

loxoribine

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
119.75, 149.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1006.0, 297.0
51.92598822539949, 29.42472666105971

imadazole quinoline

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
920.0, 241.5
54.37311330247535, 33.53008653652647

loxoribine: TLR7

--

e21

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
919.0, 376.5
58.21292010464882, 35.897967397866786

imadazole quinoline: TLR8

--

e22

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
126.0, 596.5
51.475145904608574, 31.74300664117529

flagellin: TLR9

--

e23

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
262.5, 137.0
43.975005481254115, 85.11291383468537

LPS:CD14: TLR4: MD-2: MyD88

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
385.5, 296.0
29.59106460052324, 47.985510163010666

Mal

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
334.5, 123.0
42.47971935978953, 82.21881166410876

LPS:CD14: TLR4: MD-2: MyD88: TIRAP: Mal

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
131.5, 281.0
48.33172549879413, 93.54527515895637

LPS:CD14: TLR4: MD-2: TRIF

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
503.0, 275.0
41.5, 41.5

IRAK-4 {activated}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
506.0, 414.0
44.0, 44.0

TRAF6

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
136.87518862352903, 167.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
601.0, 505.0
38.0, 38.0

NF-kappaB {activated}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p18 p19

--

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
834.5, 514.0
42.15747375437428, 51.62139643392767

PGN: Nod1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
838.5, 626.0
43.0883186135644, 52.76120646558906

PGN: Nod2

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
168.55678757705792, 197.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
184.5, 151.0
47.88474949532025, 66.81592952835382

CD14: TLR4: MD-2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
301.0, 867.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
351.29367619468036, 877.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
307.06992643728904, 872.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
307.93705878547314, 873.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
301.0, 867.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
301.0, 867.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
307.93705878547314, 873.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
640.9158804881849, 1040.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
564.6082338479803, 1161.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
301.0, 867.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
132.5, 186.0
39.122122341591755, 75.72023679017758

LPS:CD14: TLR4: MD-2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
410.7511016961721, 1054.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
410.25867587120234, 1033.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
431.43298634490145, 1092.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
131.0, 155.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
134.0, 176.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
142.0, 197.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
137.0, 73.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m155666*0.1

nodelay

--

true

0

false

PMID: 15576198 the lipopolysaccharide (LPS) receptor is made up of at least three proteins, CD14, MD-2 and TLR4.

Go back
265.0, 237.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 15576198, 12872135 MyD88 also contains a TIR domain, which associates with the TIR domain of the TLRs.

Go back
341.0, 241.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m6810*m25*m24*0.1

nodelay

--

true

0

false

PMID: 15576198 A family of proteins with TIR domains that are structurally and functionally related to MyD88 has been identified. This family includes proteins named TIRAP and TRIF.

Go back
253.0, 401.0
30.0, 30.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c35 : 1
stoichiometry:c37 : 1

m18998*m6*0.1

nodelay

--

true

0

false

PMID: 15576198 A family of proteins with TIR domains that are structurally and functionally related to MyD88 has been identified. This family includes proteins named TIRAP and TRIF.

Go back
429.0, 225.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m26*m17258*0.1

nodelay

--

true

0

false

PMID: 15576198 A number of studies indicates roles of TRAF6 and members of the IRAK family (interleukin-1-associated receptor kinase), most notably IRAK-4, downstream of MyD88.

Go back
429.0, 353.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1

m183*m28*0.1

nodelay

--

true

0

false

PMID: 15576198 A number of studies indicates roles of TRAF6 and members of the IRAK family (interleukin-1-associated receptor kinase), most notably IRAK-4, downstream of MyD88.

Go back
513.0, 509.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m30*m29*0.1

nodelay

--

true

0

false

PMID: 15576198 This highly conserved pathway is linked to activation of the NF-kappaB pathway.

Go back
1017.0, 453.0
30.0, 30.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m4923*m155701*0.1

nodelay

--

true

0

false

PMID: 15576198, 12791997, 12796777 both proteins recognize monomeric components of peptidoglycan.

Go back
1017.0, 709.0
30.0, 30.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m155701*m4947*0.1

nodelay

--

true

0

false

PMID: 15576198, 12791997, 12796777 both proteins recognize monomeric components of peptidoglycan.

Go back
513.0, 565.0
30.0, 30.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c54 : 1

m30*m32*m2684*0.1

nodelay

--

true

0

false

PMID: 15576198 Binding of the cognate ligants to NOD1 or NOD2 leads to activation of NF-kappaB by a mechanism requiring the presence of the kinase known as RICK (Rip2).

Go back
509.0, 617.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c56 : 1

m30*m33*m2684*0.1

nodelay

--

true

0

false

PMID: 15576198 Binding of the cognate ligants to NOD1 or NOD2 leads to activation of NF-kappaB by a mechanism requiring the presence of the kinase known as RICK (Rip2).

Go back
657.0, 69.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.

Go back
805.0, 81.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.

Go back
601.0, 73.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m13*m11*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.

Go back
869.0, 77.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m12*m16*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 TLR2?TLR1 heterodimers recognize diacylated lipopeptides whereas TLR2?TLR6 heterodimers recognize triacylated lipopeptides.

Go back
137.0, 469.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m17*m19828*0.1

nodelay

--

true

0

false

PMID: 15576198, 12467249 It has been shown that TLR9, receptor for bacterial DNA containing sequences of non-methylated CpG sequences, is localized and acts in an intracellular compartment.

Go back
1009.0, 241.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19940*m19*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 More recently, synthetic nucleoside analogues loxoribine and imadazole quinolines have been identified as ligands for TLR7 and TLR8, respectively.

Go back
1017.0, 377.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19823*m20*0.1

nodelay

--

true

0

false

PMID: 15576198, 12524386, 14498823, 12960260 More recently, synthetic nucleoside analogues loxoribine and imadazole quinolines have been identified as ligands for TLR7 and TLR8, respectively.

Go back
57.0, 597.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 15576198, 10963608 Biochemical studies have shown the direct binding of LPS-TLR4 and bacterial flagellin protein-TLR5.

Go back
165.0309682041927, 109.91023120718746

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 49.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 111.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.3343588757587, 103.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.0, 113.4753747837033

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.0, 92.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 107.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
102.0, 484.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.76638371117997, 498.2680266485904

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
167.0, 484.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.0, 222.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.0, 88.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 193.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.9967366916856, 256.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.0, 342.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 326.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.997501171265, 392.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
72.0, 565.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.36662955296687, 566.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
87.0, 612.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.0, 228.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 275.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.0, 103.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 229.98228126285287

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 279.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.6039472493969, 277.5424513544061

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 204.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 213.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.0, 251.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.1554175279993, 391.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
186.3055042995707, 351.9234759599388

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 182.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.0, 240.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.5334722010213, 106.1773654083243

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 250.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 368.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 380.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.91952058716754, 315.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.0, 524.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 524.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 458.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
879.0, 468.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 491.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.3908477088509, 474.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 107.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 617.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 724.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.3699964912911, 664.1117762963229

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 537.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 540.1333197430754

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0, 543.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 548.9703634757481

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.9431433541382, 543.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.9856387637262, 633.4791383258236

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.7553309962642, 585.9633749357631

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.017084139092, 99.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.8372978551705, 612.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
780.0, 117.79922153369904

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 114.10414291800258

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 111.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back