1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15585304.csml convertedTime:2009.07.01.10:49

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title A novel negative regulator for IL-1 receptor and Toll-like receptor 4.
Authors Liew FY, Liu H, Xu D.
Affiliation Division of Immunology, Infection and Inflammation, University of Glasgow,Glasgow G11 6NT, UK. fyl1h@clinmed.gla.ac.uk
Abstract The Toll-IL-1 receptor (TIR) superfamily, defined by the presence of anintracellular TIR domain, initiates innate immunity via NF-kappaB activation,leading to production of proinflammatory cytokines. ST2 is a member of the TIRfamily that does not activate NF-kappaB and has been suggested as an importanteffector molecule of type 2 T helper cell responses. We have recentlydemonstrated that the membrane bound form of ST2 (ST2L) negatively regulatedIL-1RI and TLR4 but not TLR3 signaling by sequestrating the adaptors MyD88 andMal. In contrast to wild-type mice, ST2 deficient mice failed to developendotoxin tolerance. Thus, ST2 suppresses IL-1R and TLR4 signaling via MyD88-and Mal-dependent pathways and modulates innate immunity. The results provide amolecular explanation for the role of ST2 in T(H)2 responses since inhibition ofTLRs will promote a T(H)2 response and also identify ST2 as a key regulator ofendotoxin tolerance.
PMID 15585304
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010657:IL-12 p40 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000016569:IRAK-M MO000016573:MyD88 MO000016589:IL-1alpha MO000016597:IL-1beta MO000016882:LPS MO000017265:IL-12 MO000017793:Lp MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000039077:IRAK-4 MO000042012:TLR9 MO000044786:ST2 MO000068831:MAL e1: e10: e11:ligand: TLR: MyD88 e12:ligand: TLR: MyD88: IRAK-1: IRAK-4 e13:IRAK-1: IRAK-4: TRAF6 e14:p38{activated} e15:JNK{activated} e16:ERK{activated} e17:NF-kappaB{activated} e18:proinflammatory protein e19:proinflammatory protein e2: e20:LPS: TLR4 e21:LPS: TLR4: MAL e22:CpG DNA e23:CpG DNA: TLR9 e24:Pam3Cys-SK4: TLR2 e25:Lp: TLR2 e26:Pam3Cys-SK4 e27:Lp: TLR2: MAL e28:ST2 e29:MyD88s e3: e30:ligand: TLR: MyD88: IRAK-1: IRAK-4{activated} e31:IRAK-1: IRAK-1 e32:ligand: ST2 e33:ST2 ligand e34:ligand: ST2: MAL e35:ligand: ST2: MAL: MyD88 e36:IL-1: IL-1R1 e37:MAPKs{activated} e4: e5:TLR ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ligand: TLR e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p5 p6 p7 p8 p9
Model Detail
696.0, 812.0
31.0, 31.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
652.0, 976.0
31.5, 31.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p17 p18

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
703.0, 887.0
33.0, 33.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
354.0, 630.0
28.0, 28.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
354.0, 462.0
28.0, 28.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
354.0, 542.0
30.5, 30.5

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
353.0, 717.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p39 p40

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
433.0, 249.0
29.0, 29.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
360.0, 412.0
31.0, 31.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
289.0, 217.0
29.0, 29.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
614.0, 1046.0
28.0, 28.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p18

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
869.0, 705.0
29.5, 29.5

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
357.0, 333.0
30.0, 30.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
300.0, 160.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p38

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
978.0, 790.0
35.0, 35.0

IL-1alpha

--

MO000016589

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p15 p17

true true true true

csml-variable:Double

m1584

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016589

--

Go back
1016.0, 936.0
31.0, 31.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p16 p18

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
976.0, 140.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p33

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
855.0, 967.0
33.0, 33.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
806.0, 34.0
27.0, 27.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
896.0, 140.0
31.0, 31.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
156.0, 102.0
26.5, 26.5

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
685.0, 104.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p25

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
320.0, 252.0
31.0, 31.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
892.0, 332.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
554.0, 106.0
28.0, 28.0

ST2

--

MO000044786

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m22456

10

false

infinite

0

unit false false false
TRANSPATHMO000044786

--

Go back
767.0, 203.0
33.0, 33.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p26 p37

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
140.77279425122504, 102.2982310407159
801.2413304500363, 1049.3615791456652

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
147.06394391764843, 115.36883147718339
774.2554383859111, 982.3963951901337

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
148.875, 208.5
32.25, 45.0

ligand: TLR: MyD88

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
147.875, 264.5
32.25, 45.0

ligand: TLR: MyD88: IRAK-1: IRAK-4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
225.875, 408.5
27.783492383923655, 38.767663791521386

IRAK-1: IRAK-4: TRAF6

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
355.0, 503.0
26.0, 26.0

p38{activated}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p9

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
354.0, 582.0
30.5, 30.5

JNK{activated}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
355.0, 667.0
28.0, 28.0

ERK{activated}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
353.0, 765.0
30.0, 30.0

NF-kappaB{activated}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
523.5, 849.0
40.22491349480967, 21.453287197231816

proinflammatory protein

--

e18

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9 p10 p11 p12

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
374.5, 849.125
34.7967397866774, 21.45798953511773

proinflammatory protein

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9 p10 p11 p12

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
140.77279425122504, 102.2982310407159
801.2413304500363, 1049.3615791456652

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
892.625, 200.5
31.23025329111815, 38.24112647892018

LPS: TLR4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
893.875, 263.5
28.927739034685263, 40.36428702514223

LPS: TLR4: MAL

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1001.5, 332.125
45.0, 15.75

CpG DNA

--

e22

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
892.625, 380.5
31.09960839860023, 38.08115314114314

CpG DNA: TLR9

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
621.625, 94.5
28.91130644892518, 35.40159973337777

Pam3Cys-SK4: TLR2

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
739.625, 91.5
33.639018496917174, 41.1906348941843

Lp: TLR2

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
549.5, 35.25
45.0, 25.5

Pam3Cys-SK4

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p25

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
823.875, 85.5
32.25, 45.0

Lp: TLR2: MAL

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
550.5, 823.0
34.982698961937714, 18.657439446366777

ST2

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p33

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
334.5, 290.125
35.88, 26.909999999999997

MyD88s

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
156.79762086022572, 116.7522472823918
769.1916772320347, 1020.4535466623144

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
147.875, 324.5
32.25, 45.0

ligand: TLR: MyD88: IRAK-1: IRAK-4{activated}

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
238.625, 368.5
26.037118813531077, 31.882186302282957

IRAK-1: IRAK-1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
485.625, 98.5
29.31957173804366, 35.90151641393101

ligand: ST2

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
424.5, 41.375
31.889279437609837, 20.7280316344464

ST2 ligand

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
411.875, 85.5
32.25, 45.0

ligand: ST2: MAL

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
322.875, 99.5
34.751559919251235, 48.49054872453661

ligand: ST2: MAL: MyD88

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
144.375, 757.5
23.25, 45.0

IL-1: IL-1R1

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p40

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
437.0, 297.0
29.0, 29.0

MAPKs{activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
186.44355008687728, 142.04677570532448
709.8998187787327, 969.8644898164486

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
82.0, 104.5
30.931458699472756, 20.105448154657292

TLR ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
483.68072003060274, 786.2017107271437
300.8313060202111, 246.0780654755593

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
516.1727419098804, 792.0334031376776
175.90508396712534, 238.49865894140441

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
487.6021709470675, 789.4861202252774
292.98840418728247, 239.50924647929156

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
488.16237822084776, 789.9914139942211
291.8679896397209, 238.49865894140441

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
483.68072003060274, 786.2017107271437
300.8313060202111, 246.0780654755593

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
483.68072003060274, 786.2017107271437
300.8313060202111, 246.0780654755593

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
488.16237822084776, 789.9914139942211
291.8679896397209, 238.49865894140441

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
703.281971352619, 887.2604645158749
18.794287081306322, 15.346025009741506

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
653.983731259922, 958.0015921679857
53.21969100916211, 43.45526412915422

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
483.68072003060274, 786.2017107271437
300.8313060202111, 246.0780654755593

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
148.625, 156.5
31.23025329111815, 38.24112647892018

ligand: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
554.5849661983157, 895.5567696646879
9.526885436487929, 4.137383043173348

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
554.2668365269649, 883.2181143643252
32.608291313458814, 52.941439602718965

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
567.9464123950504, 917.6515710165006
5.090074741613079, 4.591127553623328

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
149.35163470543878, 105.73942978832443
640.3427513281786, 818.4075561935268

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
151.6393254932291, 120.1835323216129
614.288431526305, 804.515011969361

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
157.73983426067, 134.62763485490134
611.4838678780549, 793.9639991806044

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
82.0, 162.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3962*m5*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
439.0, 846.0
27.0, 27.0

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c36 : 1
stoichiometry:c28 : 1

m22*m18*0.1

nodelay

--

true

0

false

PMID: 15585304 These molecules in turn promote the production of many proinflammatory proteins and enhance immune reactivity.

Go back
437.0, 802.0
27.0, 27.0

p11

p11

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c35 : 1
stoichiometry:c27 : 1

m22*m17*0.1

nodelay

--

true

0

false

PMID: 15585304 These molecules in turn promote the production of many proinflammatory proteins and enhance immune reactivity.

Go back
438.0, 889.0
27.0, 27.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c37 : 1
stoichiometry:c29 : 1

m22*m19*0.1

nodelay

--

true

0

false

PMID: 15585304 These molecules in turn promote the production of many proinflammatory proteins and enhance immune reactivity.

Go back
786.0, 794.0
27.0, 27.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c46 : 1
stoichiometry:c38 : 1

m93248*m1584*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
819.0, 827.0
25.0, 25.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c48 : 1
stoichiometry:c39 : 1

m93248*m1591*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
807.0, 859.0
25.0, 25.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c47 : 1
stoichiometry:c42 : 1

m93589*m1584*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
807.0, 939.0
25.0, 25.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c49 : 1
stoichiometry:c43 : 1

m93589*m1591*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
691.0, 1047.0
25.0, 25.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c54 : 1

m1584*m93309*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
660.0, 1080.0
23.0, 23.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c55 : 1

m1591*m93309*0.1

nodelay

--

true

0

false

PMID: 15585304, Although macrophages from wild-type (WT) mice produced minimal amounts of IL-6, IL-12 and Tumour necrosis factor (TNF) in response to IL-1alpha and IL-1beta, those from ST2-deficient mice produced large amounts of these cytokines under identical culture conditions.

Go back
978.0, 206.0
27.0, 27.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 15585304 Macrophages from ST2-deficient mice also produced significantly more IL-6 and IL-12 than cells from the WT mice when stimulated with LPS, a ligand of TLR4.

Go back
230.0, 162.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
786.0, 750.0
27.0, 27.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1
stoichiometry:c59 : 1

m93248*m24*0.1

nodelay

--

true

0

false

PMID: 15585304 Macrophages from ST2-deficient mice also produced significantly more IL-6 and IL-12 than cells from the WT mice when stimulated with LPS, a ligand of TLR4.

Go back
807.0, 895.0
25.0, 25.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c61 : 1

m93589*m24*0.1

nodelay

--

true

0

false

PMID: 15585304 Macrophages from ST2-deficient mice also produced significantly more IL-6 and IL-12 than cells from the WT mice when stimulated with LPS, a ligand of TLR4.

Go back
830.0, 206.0
27.0, 27.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m24*m43675*0.1

nodelay

--

true

0

false

PMID: 15585304, 11544529, 12447441 A similar effect was observed following overexpression of the TIR domain-containing adaptor Mal, which is involved in signaling from TLR4 and TLR2.

Go back
743.0, 35.0
25.0, 25.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c76 : 1
stoichiometry:c74 : 1
stoichiometry:c79 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
1012.0, 388.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m19828*m26*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
623.0, 35.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m3964*m30*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
742.0, 162.0
27.0, 27.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m43675*m29*0.1

nodelay

--

true

0

false

PMID: 15585304, 11544529, 12447441 A similar effect was observed following overexpression of the TIR domain-containing adaptor Mal, which is involved in signaling from TLR4 and TLR2.

Go back
786.0, 706.0
27.0, 27.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c82 : 1

m93248*m27*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
786.0, 662.0
28.0, 28.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1
stoichiometry:c81 : 1

m93248*m29*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
767.0, 619.0
25.0, 25.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c88 : 1
stoichiometry:c80 : 1

m93248*m28*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
232.0, 220.0
24.0, 24.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c101 : 1
stoichiometry:c9 : 1

m11*m184*m17258*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2. PMID: 15585304, 12538665 MyD88s, a splice variant of MyD88, prevents IRAK-4 recruitment.

Go back
768.0, 992.0
23.0, 23.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c90 : 1

m28*m93589*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
734.0, 1018.0
27.0, 27.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c97 : 1
stoichiometry:c91 : 1

m27*m93589*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
796.0, 972.0
23.0, 23.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c89 : 1

m29*m93589*0.1

nodelay

--

true

0

false

PMID: 15585304 A similar elevation of proinflammatory cytokine production was observed when the cells were stimulated with BLP (bacterial lipoprotein, Pam3Cys-SK4, ligand for TLR2), and CpG (ligand for TLR9).

Go back
555.0, 499.0
25.0, 25.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c98 : 1

m32*m155666*0.1

nodelay

--

true

0

false

PMID: 15585304 However, when the cells were cultured with LPS, ST2 was clearly detected by 4 h and sustained for at least 48 h.

Go back
289.0, 333.0
29.0, 29.0

p34

p34

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c102 : 1
stoichiometry:c11 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 15585304, 12150927 IRAK-M also interferes with IRAK function by preventing dissociation of IRAK from the signaling complex.

Go back
247.0, 271.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
487.0, 39.0
26.0, 26.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m22456*m37*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 appears to exert its negative regulatory function on IL-1RI and TLR4 mediated NF-kappaB activation via sequestrating TLR proximal signaling components, MyD88 and Mal.

Go back
488.0, 208.0
24.0, 24.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m36*m43675*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 appears to exert its negative regulatory function on IL-1RI and TLR4 mediated NF-kappaB activation via sequestrating TLR proximal signaling components, MyD88 and Mal.

Go back
374.0, 162.0
27.0, 27.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m38*m1572*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 appears to exert its negative regulatory function on IL-1RI and TLR4 mediated NF-kappaB activation via sequestrating TLR proximal signaling components, MyD88 and Mal.

Go back
458.0, 718.0
27.0, 27.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c118 : 1

m14*m25*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 appears to exert its negative regulatory function on IL-1RI and TLR4 mediated NF-kappaB activation via sequestrating TLR proximal signaling components, MyD88 and Mal.

Go back
298.0, 414.0
27.0, 27.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c104 : 1
stoichiometry:c13 : 1

m183*m35*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
261.0, 765.0
27.0, 27.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m40*m14*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 appears to exert its negative regulatory function on IL-1RI and TLR4 mediated NF-kappaB activation via sequestrating TLR proximal signaling components, MyD88 and Mal.

Go back
375.0, 251.0
25.0, 25.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m69*m39*0.1

nodelay

--

true

0

false

PMID: 15585304 ST2 is able to activate MAP kinases but not NF-kappaB.

Go back
287.0, 463.0
25.0, 25.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c22 : 1
stoichiometry:c15 : 1

m20*m13*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
287.0, 543.0
27.0, 27.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c23 : 1
stoichiometry:c17 : 1

m21*m13*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
283.0, 631.0
25.0, 25.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c24 : 1
stoichiometry:c19 : 1

m16*m13*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
266.0, 718.0
27.0, 27.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c25 : 1
stoichiometry:c21 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 15585304, 12467243 These adaptors are recruited to receptor TIR domains and initiate signaling processes through IL-1R-associated kinases (IRAKs) and the adaptor molecule TRAF-6, which leads to activation of four protein kinase cascades, culminating in the activation of NF-kappaB and the MAP kinases p38, JNK and ERK1/2.

Go back
440.0, 755.0
25.0, 25.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c34 : 1
stoichiometry:c26 : 1

m22*m15*0.1

nodelay

--

true

0

false

PMID: 15585304 These molecules in turn promote the production of many proinflammatory proteins and enhance immune reactivity.

Go back
115.15649355304078, 126.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.451658795837, 239.91080421712383

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.9987814189168, 155.9256002564997

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.34115720523516, 242.19924271737

c101

c101

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
187.14577023677901, 250.12147519731585

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.0, 284.238699645135

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 393.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
186.68695227583535, 293.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.0, 347.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.0, 348.0

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
518.6568542494924, 70.65685424949238

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 52.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.52819584881325, 358.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 65.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 134.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.35684354282563, 137.7095390559515

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.0, 220.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.1804964634343, 131.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.3343588757586, 148.9619305082008

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 176.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 732.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.2494651199621, 738.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.9994777227532, 284.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.0, 428.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 136.0

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
168.0, 779.0860165328912

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.13333415406544, 739.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 779.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
59.728416841732496, 43.756543188355295

c124

c124

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
408.0, 264.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 273.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 148.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
262.0, 428.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 476.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 483.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 557.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.0, 565.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 644.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 650.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
96.21613729078332, 125.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.0, 732.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 739.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.0, 439.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.0, 447.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
245.0, 447.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.0, 447.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
403.4376015698018, 780.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.42478422587044, 826.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 860.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.5240571578817, 875.629976047529

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
109.0, 176.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.2494651199621, 825.383083722649

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.6154137517749, 785.6979933657716

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 860.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.2744631916617, 870.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
372.0, 529.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 613.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 695.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.75088179975995, 795.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.0, 740.7535311206782

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.0, 742.3365604500259

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.0, 176.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.0, 812.8470183397434

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
727.0, 830.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
826.0, 884.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.0, 959.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 878.4654160868196

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 912.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
821.0, 808.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.9999544989574, 825.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.9999997331729, 839.9515144261953

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 952.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.0, 176.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.9999970139454, 825.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.9995814530516, 967.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 1008.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.0, 1008.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
650.0, 1060.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.485433827199, 1074.6839244307548

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 168.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 172.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 220.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 731.6788339812916

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.5727049087314, 186.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 778.7118866892794

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 920.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 905.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.9999999867263, 227.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.9999999418818, 224.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 220.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 233.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 220.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.0, 355.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 348.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
181.0, 231.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 400.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.3064601145268, 65.98677551382512

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 60.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.0, 66.19165839362657

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 60.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 48.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 48.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.326060730508, 195.72942780301244

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 133.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 57.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 232.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 642.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 683.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 720.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.0, 651.5620266584081

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
721.0, 696.914338746484

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.0, 739.216126159956

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
807.5614885950756, 419.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 127.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.7984621356211, 130.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
819.0, 984.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
186.57753753315023, 240.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.0, 989.7095750304435

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.0, 993.8611781328564

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.9975892639322, 419.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 59.62677105138181

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
645.0, 19.512753072144505

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 919.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.0, 920.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.0, 920.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 142.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 532.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back