1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/15694833.csml convertedTime:2009.07.01.10:50

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The serine/threonine kinase Pim-1.
Authors Bachmann M, Moroy T.
Affiliation Institut fur Zellbiologie (Tumorforschung), Universitaetsklinikum Essen, IFZ,Virchowstrasse 173, D-45122 Essen, Germany.
Abstract The human pim-1 gene encodes a serine/threonine kinase, which belongs to thegroup of calcium/calmodulin-regulated kinases (CAMK). It contains acharacteristic kinase domain, a so-called ATP anchor and an active site. Inmouse and human, two Pim-1 proteins are produced from the same gene by using analternative upstream CUG initiation codon, a 44 kD and another, shorter 34 kDform that both contain the kinase domain. Expression of Pim-1 is widespread andranges from the hematopoietic and lymphoid system to prostate, testis and oralepithelial cells. Two other proteins with significant sequence similaritiesexist, Pim-2 and Pim-3; both are also serine/threonine kinases and have largelyoverlapping functions. Pim-1 is able to phosphorylate different targets, most ofwhich are involved in cell cycle progression or apoptosis. Pim-1 expression canbe induced by several external stimuli in particular by a number of cytokinesrelevant in the immune system, which led to the labeling of Pim-1 as a "booster"for the immune response.
PMID 15694833
Model Abstract

Entity

G010418:Pim-1 MO000000039:Bcl-2 MO000000058:NF-kappaB MO000000067:Bad MO000000071:EGF MO000000090:GM-CSFR MO000000099:GM-CSF MO000000209:TRAF2 MO000000277:p53 MO000003473:G-CSF MO000009617:c-Myb MO000011545:PRL MO000013122:STAT3 MO000016665:IFNgamma MO000016752:PP2A MO000016830:IL-7 MO000016840:IL-7R MO000016876:STAT5 MO000017004:SOCS-1 MO000017007:PIAS3 MO000017045:c-Kit MO000017046:SCF MO000017061:IL-2 MO000017120:SOCS-2 MO000017728:PRLR MO000019479:protein remnants MO000020433:Cdc25A MO000020752:eIF-4E MO000022401:Cdc25C MO000033296:Pim-1 MO000034419:SND1-p100 MO000043102:NuMA MO000068025:SNX6 e1: e10: e11:IFNgamma: IFNgamma receptor e12:c-Kit: c-Kit receptor e13:SCF: SCF receptor e14:G-CSF: G-CSF receptor e15:IFNgamma receptor e16:c-Kit receptor e17:SCF receptor e18:G-CSF receptor e19:EGF: EGF receptor e2: e20:EGF receptor e21:STAT5 {activated} e22:IL-2R e23:IL-2: IL-2R e24:IL-7: IL-7R e25:PRL: PRLR e26:GM-CSF: GM-CSFR e27:Gfi1 e28:PIAS3 {activated} e29:Abl.:Bcr e3: e30:SND1-p100: Pim-1 e31:c-Myb {activated} e32:NFATc e33:NFATc:Pim-1 e34:Bad: Pim-1 e35:SND1-p100 {p}: Pim-1 e36:Bad {pS112}: Pim-1 e37:Bcl-2 {activated} e38:Cdc25A: Pim-1 e39:Cdc25A {p}: Pim-1 e4: e40:p21Waf e41:p21Waf {p} e42:C-TAK1 e43:Pap-1 e44:NuMA {p} e45:C-TAK1 {p} e46:Cdc25C {p} e47:HP-1 e48:Pim-1: HP-1 {p} e49:Pim-1: Pap-1 {p} e5:Pim-1 {p} e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:STAT3 {activated} e60: e61: e62: e63:Pim-1: TRAF2 {p} e64:Pim-1: SNX6 {p} e65:Pim-1: HP-1 e66:Pim-1: Pap-1 e67:Pim-1: TRAF2 e68:Pim-1: SNX6 e69:SOCS-1 {p} e7: e70:SOCS-2 {p} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p6 p7 p8 p9
Model Detail
486.0, 978.0
28.0, 28.0

Pim-1

--

G010418

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p21 p22

p26

true true true true

csml-variable:Double

m93391

10

false

infinite

0

unit false false false
TRANSFACG010418

--

Go back
853.0, 241.0
29.0, 29.0

Bcl-2

--

MO000000039

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR004725
TRANSPATHMO000000039

--

Go back
541.0, 1241.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
641.0, 289.0
27.0, 27.0

Bad

--

MO000000067

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000067

--

Go back
986.0, 984.0
32.0, 32.0

EGF

--

MO000000071

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR000033
TRANSPATHMO000000071

--

Go back
689.0, 1313.0
30.0, 30.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
693.0, 1377.0
30.0, 30.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
406.0, 510.0
28.0, 28.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
589.0, 893.0
30.0, 30.0

p53

--

MO000000277

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3 p4 p5 p6

true true true true

csml-variable:Double

m220

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000277

--

Go back
987.0, 1133.0
30.0, 30.0

G-CSF

--

MO000003473

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m464

10

false

infinite

0

unit false false false
InterProIPR003629
TRANSPATHMO000003473

--

Go back
326.0, 874.0
28.0, 28.0

c-Myb

--

MO000009617

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m1158

10

false

infinite

0

unit false false false
InterProIPR001005
TRANSPATHMO000009617

--

Go back
801.0, 1373.0
30.0, 30.0

PRL

--

MO000011545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1292

10

false

infinite

0

unit false false false
InterProIPR001400
TRANSPATHMO000011545

--

Go back
606.0, 830.0
28.0, 28.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3 p4 p5 p6

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
980.0, 704.0
32.0, 32.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
348.0, 188.0
32.0, 32.0

PP2A

--

MO000016752

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m1703

10

false

infinite

0

unit false false false
TRANSPATHMO000016752

--

Go back
908.0, 1376.0
24.0, 24.0

IL-7

--

MO000016830

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m1767

10

false

infinite

0

unit false false false
InterProIPR001181
TRANSPATHMO000016830

--

Go back
895.0, 1319.0
25.0, 25.0

IL-7R

--

MO000016840

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m1776

10

false

infinite

0

unit false false false
TRANSPATHMO000016840

--

Go back
572.0, 1060.0
31.5, 31.5

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13 p14 p15 p20 p24 p25

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
619.0, 599.0
26.0, 26.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
541.0, 981.0
21.0, 21.0

PIAS3

--

MO000017007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1908

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017007

--

Go back
981.0, 813.0
30.0, 30.0

c-Kit

--

MO000017045

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1942

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017045

--

Go back
987.0, 1026.0
28.0, 28.0

SCF

--

MO000017046

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1943

10

false

infinite

0

unit false false false
InterProIPR003452
TRANSPATHMO000017046

--

Go back
986.0, 1286.0
27.0, 27.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
550.0, 598.0
28.0, 28.0

SOCS-2

--

MO000017120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m2004

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017120

--

Go back
797.0, 1317.0
30.0, 30.0

PRLR

--

MO000017728

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m2485

10

false

infinite

0

unit false false false
TRANSPATHMO000017728

--

Go back
348.0, 228.0
32.0, 32.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
656.0, 360.0
31.0, 31.0

Cdc25A

--

MO000020433

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m4922

10

false

infinite

0

unit false false false
InterProIPR001763
TRANSPATHMO000020433

--

Go back
441.0, 801.0
30.0, 30.0

eIF-4E

--

MO000020752

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m5183

10

false

infinite

0

unit false false false
TRANSPATHMO000020752

--

Go back
669.0, 549.0
30.0, 30.0

Cdc25C

--

MO000022401

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m6688

10

false

infinite

0

unit false false false
InterProIPR001763
TRANSPATHMO000022401

--

Go back
513.0, 329.0
30.0, 30.0

Pim-1

--

MO000033296

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p1 p27 p29 p30 p34 p36 p37 p38 p39 p41 p45 p46 p48 p49 p50

true true true true

csml-variable:Double

m11986

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000033296

--

Go back
223.0, 395.0
26.0, 26.0

SND1-p100

--

MO000034419

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28

true true true true

csml-variable:Double

m12962

10

false

infinite

0

unit false false false
InterProIPR008192
TRANSPATHMO000034419

--

Go back
710.0, 446.0
27.0, 27.0

NuMA

--

MO000043102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m20879

10

false

infinite

0

unit false false false
TRANSPATHMO000043102

--

Go back
450.0, 562.0
28.0, 28.0

SNX6

--

MO000068025

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m42875

10

false

infinite

0

unit false false false
TRANSPATHMO000068025

--

Go back
102.75, 100.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
111.0, 120.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
922.25, 765.0
20.05382591536944, 38.81385661039245

IFNgamma: IFNgamma receptor

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
920.375, 865.5
23.25, 45.0

c-Kit: c-Kit receptor

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
921.375, 1081.5
23.25, 45.0

SCF: SCF receptor

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
918.375, 1181.5
23.25, 45.0

G-CSF: G-CSF receptor

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p6 p12

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
916.375, 713.5
23.90377855887522, 36.7750439367311

IFNgamma receptor

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
919.375, 815.5
26.005711775043938, 40.008787346221446

c-Kit receptor

--

e16

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
921.375, 1033.5
23.6981546572935, 36.458699472759236

SCF receptor

--

e17

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
918.375, 1133.5
23.99516695957821, 36.91564147627417

G-CSF receptor

--

e18

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
919.375, 920.5
20.408956369217275, 39.501205875904404

EGF: EGF receptor

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p4

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
102.75, 100.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
918.375, 977.5
24.17794376098419, 37.196836555360285

EGF receptor

--

e20

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p11

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
480.0, 1100.0
31.5, 31.5

STAT5 {activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p13 p14 p15 p20 p24 p25

p22

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
920.375, 1286.5
23.355448154657296, 35.93145869947276

IL-2R

--

e22

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p16

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
920.375, 1233.5
21.36729883797413, 41.3560622670467

IL-2: IL-2R

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p13

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
849.625, 1314.5
29.009290118313615, 35.52157973671056

IL-7: IL-7R

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p14

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
746.625, 1315.5
27.31907182136311, 33.45192467922013

PRL: PRLR

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p15

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
630.625, 1311.5
27.44971671388102, 33.611898016997166

GM-CSF: GM-CSFR

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
540.0, 870.0
24.0, 24.0

Gfi1

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
Affymetrix103259_at
EnsemblENSMUSG00000029275
ProteomeHumanPSD/Gfi1
RGDGfi1
RefSeqNM_010278
TRANSFACT06593
TRANSPATHMO000054417
UnigeneMm.2078
UniProtP70338

--

Go back
593.0, 969.0
21.0, 21.0

PIAS3 {activated}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p2 p3 p4 p5 p6

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017007

--

Go back
482.0, 1242.0
27.0, 27.0

Abl.:Bcr

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000050779

--

Go back
119.87518862352903, 118.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
362.625, 327.5
27.449716713881017, 33.611898016997166

SND1-p100: Pim-1

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p31

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
322.0, 914.0
28.0, 28.0

c-Myb {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR001005
TRANSPATHMO000009617

--

Go back
241.5, 256.125
37.69470718454418, 23.245069430468906

NFATc

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
309.5, 288.125
37.69470718454418, 23.245069430468906

NFATc:Pim-1

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
640.625, 237.5
29.858481919680052, 36.56140643226129

Bad: Pim-1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p32

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
253.625, 326.5
28.568363606065653, 34.98166972171305

SND1-p100 {p}: Pim-1

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
756.625, 237.5
31.00979003499417, 37.971171471421435

Bad {pS112}: Pim-1

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
853.0, 281.0
29.0, 29.0

Bcl-2 {activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR004725
TRANSPATHMO000000039

--

Go back
697.625, 326.5
28.739835027495417, 35.1916347275454

Cdc25A: Pim-1

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
829.625, 326.5
28.919471754707544, 35.41159806698883

Cdc25A {p}: Pim-1

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
151.55678757705792, 148.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
728.5, 400.125
31.24, 23.429999999999993

p21Waf

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
760.5, 433.125
30.279999999999998, 22.709999999999994

p21Waf {p}

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
720.5, 500.125
31.879999999999995, 23.909999999999993

C-TAK1

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
285.5, 517.125
36.644194002817464, 22.597252968404106

Pap-1

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
760.5, 484.125
31.72, 23.789999999999996

NuMA {p}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
717.5, 537.125
29.319999999999997, 21.99

C-TAK1 {p}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
665.5, 587.125
41.96, 31.469999999999995

Cdc25C {p}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
329.125, 450.5
21.0782350573556, 34.18092171463071

HP-1

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
281.125, 461.5
22.597252968404103, 36.644194002817464

Pim-1: HP-1 {p}

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
272.5, 565.0
38.170731707317074, 30.536585365853657

Pim-1: Pap-1 {p}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
512.0, 219.75
32.72, 24.540000000000003

Pim-1 {p}

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

p1

p40

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
278.0, 744.0
523.3639451381244, 474.63359642880243

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
334.52720450281424, 755.2481262266464
306.02658989454585, 460.0144918160056

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
284.8222488193052, 750.3349453322119
509.71944749951444, 461.9637057643784

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
285.79685579349155, 751.3095523063981
507.77023355114136, 460.0144918160056

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
278.0, 744.0
523.3639451381244, 474.63359642880243

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
278.0, 744.0
523.3639451381244, 474.63359642880243

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
285.79685579349155, 751.3095523063981
507.77023355114136, 460.0144918160056

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
660.0459338810888, 938.9213948372903
32.69690366690135, 29.599302266879167

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
574.280520152681, 1075.3663712233936
92.58766254771287, 83.81619978003496

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
278.0, 744.0
523.3639451381244, 474.63359642880243

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
618.0, 1014.0
28.0, 28.0

STAT3 {activated}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p3 p4 p5 p6

p21

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
401.3539371028297, 954.9232483232652
16.574167139986017, 7.98015454888217

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
400.800478747493, 931.1245390437987
56.72948142198493, 102.11306655957293

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
424.5991880269605, 997.5395416841716
8.855333685383004, 8.855333685383016

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
283.5, 621.125
40.84, 30.63

Pim-1: TRAF2 {p}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
364.5, 645.125
38.44, 28.83

Pim-1: SNX6 {p}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
350.875, 396.5
27.238988805285373, 38.00789135621215

Pim-1: HP-1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p43

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
361.875, 503.5
28.80147733529088, 40.18810790970821

Pim-1: Pap-1

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p44

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
406.625, 559.5
27.449716713881017, 33.611898016997166

Pim-1: TRAF2

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
471.625, 616.5
32.34073487752042, 39.600899850024994

Pim-1: SNX6

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p42

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
585.5, 642.125
34.440000000000005, 25.83

SOCS-1 {p}

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
114.0, 106.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
530.5, 671.125
35.56, 26.67

SOCS-2 {p}

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
117.0, 127.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
125.0, 148.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
513.0, 273.0
30.0, 30.0

p1

p1

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000033296

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1

m11986*0.1

nodelay

--

true

0

false

PMID: 15694833 Since Pim-1 is able to phosphorylate itself but does not contain such a phosphorylation motif, it has to be questioned whether the identified Pim-1 target sequence represents the only substrate sequence.

Go back
989.0, 1191.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000003473 e18

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c28 : 1
stoichiometry:c21 : 1

m464*m18*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
989.0, 927.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000071 e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c32 : 1
stoichiometry:c30 : 1

m63*m20*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
712.0, 1064.0
23.0, 23.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 e14

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c33 : 1
stoichiometry:c39 : 1

m1798*m14*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
696.0, 1100.0
23.0, 23.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 e23

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c34 : 1
stoichiometry:c40 : 1

m1798*m23*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
668.0, 1128.0
23.0, 23.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleolus

--

MO000016876 e24

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c46 : 1
stoichiometry:c41 : 1

m1798*m24*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
632.0, 1144.0
23.0, 23.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 e25

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c53 : 1
stoichiometry:c42 : 1

m1798*m25*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
988.0, 1240.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017061 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m1954*m22*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
853.0, 1377.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016830 MO000016840

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m1767*m1776*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
748.0, 1376.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000011545 MO000017728

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m1292*m2485*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
632.0, 1380.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000099 MO000000090

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
679.0, 827.0
25.0, 25.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000013122 e11 MO000000277 e28

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c15 : 1
stoichiometry:c69 : 1
stoichiometry:c64 : 1
stoichiometry:c3 : 1

m1360*m11*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFNgamma, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF. PMID: 15694833 STAT3 is negatively regulated through Pias3 and p53.

Go back
591.0, 1155.0
25.0, 25.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 e26

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c59 : 1
stoichiometry:c55 : 1

m1798*m26*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
512.0, 1031.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6

G010418

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c60 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 15694833 Both STAT3/STAT5 can bind directly to the pim-1 promoter at the ISFR/GAS-sequence (gamma interferon activation sequences), which leads to an up regulation of pim-1 gene expression.

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464.0, 1043.0
23.0, 23.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010418

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c61 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 15694833 Both STAT3/STAT5 can bind directly to the pim-1 promoter at the ISFR/GAS-sequence (gamma interferon activation sequences), which leads to an up regulation of pim-1 gene expression.

Go back
540.0, 926.0
23.0, 23.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000017007 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m1908*0.1

nodelay

--

true

0

false

PMID: 15694833 Pias3 itself is inhibited by the onco-protein Gfi1.

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543.0, 1163.0
25.0, 25.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c81 : 1
stoichiometry:c78 : 1

m1798*m29*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 Furthermore, STATs themselves are also regulated by a number of other factors such as p53, PIAS3 and Gfi1, NFkappaB or BCR/ABL.

Go back
484.0, 1164.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016876 e29

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c82 : 1
stoichiometry:c80 : 1

m1798*m30*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 Furthermore, STATs themselves are also regulated by a number of other factors such as p53, PIAS3 and Gfi1, NFkappaB or BCR/ABL.

Go back
491.0, 691.0
25.0, 25.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010418 MO000020752

MO000033296

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c121 : 1

m93391*m5183*0.1

nodelay

--

true

0

false

PMID: 15694833, 9419425 One study reports that the Pim-1 protein expression level can be enhanced by the eukaryotic translation initiation factor 4 E (eIF-4E).

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428.0, 332.0
23.0, 23.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 MO000034419

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m11986*m12962*0.1

nodelay

--

true

0

false

PMID: 15694833, 9809063 The first binding partner identified as a Pim-1 substrate was the nuclear adapter protein p100, which is an activator of the c-Myb transcription factor.

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380.0, 876.0
24.0, 24.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000009617 MO000034419

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c100 : 1
stoichiometry:c89 : 1

m1158*m12962*0.1

nodelay

--

true

0

false

PMID: 15694833, 9809063 The first binding partner identified as a Pim-1 substrate was the nuclear adapter protein p100, which is an activator of the c-Myb transcription factor.

Go back
426.0, 274.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m11986*m33*0.1

nodelay

--

true

0

false

PMID: 15694833, 11823475 Another identified protein is the transcription factor NFATc, which is involved in relaying signals from the T-cell receptor.

Go back
715.0, 875.0
25.0, 25.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000013122 e12 MO000000277 e28

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c22 : 1
stoichiometry:c70 : 1
stoichiometry:c65 : 1
stoichiometry:c4 : 1

m1360*m12*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFNgamma, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF. PMID: 15694833 STAT3 is negatively regulated through Pias3 and p53.

Go back
580.0, 244.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 MO000000067

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1

m11986*m36*0.1

nodelay

--

true

0

false

PMID: 15694833 Most recently, the pro-apoptotic protein Bad was found to co localize and physically interact with Pim-1 resulting in a phosphorylation of Bad on serine 112, which is a gatekeeper site for Bad inactivation.

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315.0, 331.0
25.0, 25.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c99 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 15694833, 9809063 The first binding partner identified as a Pim-1 substrate was the nuclear adapter protein p100, which is an activator of the c-Myb transcription factor.

Go back
700.0, 244.0
24.0, 24.0

p32

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 15694833 Most recently, the pro-apoptotic protein Bad was found to co localize and physically interact with Pim-1 resulting in a phosphorylation of Bad on serine 112, which is a gatekeeper site for Bad inactivation.

Go back
809.0, 245.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000039 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m39*m38*0.1

nodelay

--

true

0

false

PMID: 15694833, 15280015 This suggested a direct functional role of Pim-1 in preventing cell death since the inactivation of Bad can enhance Bcl-2 activity and thereby promotes cell survival.

Go back
588.0, 332.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 MO000020433

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m11986*m4922*0.1

nodelay

--

true

0

false

PMID: 15694833, 11232315 The phosphorylation by Pim-1 significantly enhances the phosphatase activity of Cdc25A, which leads to an amplification of its positive effect on cells to transit through the G1 and S phases.

Go back
762.0, 330.0
28.0, 28.0

p35

p35

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 15694833, 11232315 The phosphorylation by Pim-1 significantly enhances the phosphatase activity of Cdc25A, which leads to an amplification of its positive effect on cells to transit through the G1 and S phases.

Go back
649.0, 397.0
22.0, 22.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e40 MO000033296

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m43*m11986*0.1

nodelay

--

true

0

false

PMID: 15694833, 12431783 Later on, the CKI (cycline kinase inhibitor) p21Waf, which inhibits G1/S progression was found to be inactivated by Pim-1 phosphorylation.

Go back
639.0, 435.0
25.0, 25.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000043102 MO000033296

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m20879*m11986*0.1

nodelay

--

true

0

false

PMID: 15694833, 12111331 In 2002, the nuclear mitotic apoptosis protein (NuMA protein), which is responsible for the organization of the spindle apparatus in the M phase, was found to be phosphorylated by Pim-1.

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618.0, 466.0
27.0, 27.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e42 MO000033296

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m45*m11986*0.1

nodelay

--

true

0

false

PMID: 15694833 Apparently, Pim-1 can phosphorylate both proteins, which leads in case of C-TAK1 to an inactivation and in the case of Cdc25C to an activation.

Go back
595.0, 495.0
25.0, 25.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000022401 MO000033296

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m6688*m11986*0.1

nodelay

--

true

0

false

PMID: 15694833 Apparently, Pim-1 can phosphorylate both proteins, which leads in case of C-TAK1 to an inactivation and in the case of Cdc25C to an activation.

Go back
728.0, 932.0
24.0, 24.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000013122 e19 MO000000277 e28

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c23 : 1
stoichiometry:c71 : 1
stoichiometry:c66 : 1
stoichiometry:c5 : 1

m1360*m19*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFNgamma, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF. PMID: 15694833 STAT3 is negatively regulated through Pias3 and p53.

Go back
429.0, 213.0
25.0, 25.0

p40

p40

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e5 MO000016752

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c150 : 1

m5*m1703*0.1

nodelay

--

true

0

false

PMID: 15694833 Pim-1 is post-transcriptionally regulated by stabilization on the mRNA and protein level and degraded by PP2A.

Go back
404.0, 396.0
23.0, 23.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 e47

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m11986*m64*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
427.0, 623.0
25.0, 25.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c133 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
295.0, 403.0
25.0, 25.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e65

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c125 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
328.0, 540.0
23.0, 23.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c127 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
413.0, 445.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 e43

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c131 : 1
stoichiometry:c135 : 1

m11986*m46*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
443.0, 475.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 MO000000209

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m11986*m180*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
355.0, 587.0
26.0, 26.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e67

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
475.0, 511.0
26.0, 26.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033296 MO000068025

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c132 : 1

m11986*m42875*0.1

nodelay

--

true

0

false

PMID: 15694833 Apart from cell cycle regulators, other binding partners and potential substrates of Pim-1 have been identified. Among them, the proteins are HP-1, PAP-1 and TRAF2/SNX6.

Go back
558.0, 522.0
27.0, 27.0

p49

p49

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000033296 MO000017004

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m11986*m1906*0.1

nodelay

--

true

0

false

PMID: 15694833, 11854514, 14764533 Two other Pim-1 substrates, SOCS1 and SOCS3 also belong to the group of adapter proteins and are involved in the negative regulation of STATs or TNF-receptor signal transduction pathways.

Go back
731.0, 975.0
25.0, 25.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000013122 e13 MO000000277 e28

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c24 : 1
stoichiometry:c72 : 1
stoichiometry:c67 : 1
stoichiometry:c6 : 1

m1360*m13*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFNgamma, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF. PMID: 15694833 STAT3 is negatively regulated through Pias3 and p53.

Go back
518.0, 530.0
27.0, 27.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000033296 MO000017120

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m11986*m2004*0.1

nodelay

--

true

0

false

PMID: 15694833, 11854514, 14764533 Two other Pim-1 substrates, SOCS1 and SOCS3 also belong to the group of adapter proteins and are involved in the negative regulation of STATs or TNF-receptor signal transduction pathways.

Go back
728.0, 1024.0
23.0, 23.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000013122 e14 MO000000277 e28

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c31 : 1
stoichiometry:c73 : 1
stoichiometry:c68 : 1
stoichiometry:c7 : 1

m1360*m14*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFNgamma, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF. PMID: 15694833 STAT3 is negatively regulated through Pias3 and p53.

Go back
982.0, 770.0
27.0, 27.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016665 e15

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c25 : 1
stoichiometry:c14 : 1

m1639*m15*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
982.0, 874.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017045 e16

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c26 : 1
stoichiometry:c17 : 1

m1942*m16*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
989.0, 1092.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017046 e17

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c27 : 1
stoichiometry:c19 : 1

m1943*m17*0.1

nodelay

--

true

0

false

PMID: 15694833, 12773095 STAT3 is activated by many interleukins, IFN¦Ã, c-Kit, SCF, G-CSF and EGF similar to STAT5, which is activated in particular by IL-2 and IL-7, Prolactin, G-CSF and GM-CSF.

Go back
528.0, 311.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 856.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.76271057485008, 421.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.9909451017955, 256.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 266.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 256.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.0, 344.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.3104923889621, 352.2491077284276

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.0, 344.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 344.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 344.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.9893198795369, 408.4132406834243

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 858.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 411.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 351.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.8816940385574, 451.37072939801

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 453.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 357.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
652.6570420801979, 486.31726273479677

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 489.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 359.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
626.4470545031276, 521.7366114716855

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.0, 359.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0, 858.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 520.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 366.9824934004874

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.9810426273839, 227.55041673292303

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.0, 208.0

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.9509135032859, 353.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.83231466980436, 428.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
439.4488315398183, 359.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.89547372126214, 559.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 421.98341425415765

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.90697358120497, 410.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.0, 736.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.5777087639997, 359.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.0, 467.08256311696476

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 537.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
410.38461538461536, 642.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 416.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.6336570575136, 466.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.19165839362654, 534.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 505.65685424949237

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.9711254108328, 500.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.2636750760036, 582.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 784.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.01449926937056, 607.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.74631870486496, 359.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 544.2121844597461

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 636.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 359.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.0, 359.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.9975603804354, 555.2469504755443

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 549.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.3636881022716, 564.2584848522703

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 557.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.7896740909931, 786.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.80573001674856, 229.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.0, 843.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 888.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1001.0, 1054.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 1104.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 252.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 1163.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 1204.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 888.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.9977061753588, 940.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
762.8047565563683, 999.2065767803005

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
940.0, 742.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 847.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 1061.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 1161.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1002.0, 960.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.445029191864, 852.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 940.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.9871799522356, 1051.3060037900052

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
943.0, 954.9304660932648

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.7902327210916, 1087.2299810393686

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.7479091886744, 1123.2971760007479

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 1081.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 1076.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 1087.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 1092.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.8802437372457, 1078.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.5174713247359, 900.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.9981103105913, 1112.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.9350533174868, 1119.017314527883

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.7136431424303, 1122.1212518641682

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 1271.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.0, 1265.891580008606

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.9924492668405, 1252.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.5337308970231, 1156.777354269848

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
882.0, 1388.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.9509778128281, 1344.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 1358.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.3065262678806, 953.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 1388.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.4513482233507, 1347.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 1357.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.3961080956833, 1173.6838786352737

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.0, 1092.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.2093339339347, 1127.467780879614

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.0, 1392.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.4975988310086, 1343.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 1353.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.9402850002907, 1187.7611400011626

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.5439226686631, 993.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.46184854067815, 1013.2121844597461

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.0, 1013.4822900596503

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
542.9306552339244, 1030.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.4625622833173, 1073.6115561484353

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0, 855.3936217260314

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
614.0, 900.3847105554366

c65

c65

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
614.0, 948.0179731971185

c66

c66

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
614.0, 981.0

c67

c67

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
614.0, 984.0

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
619.0, 852.4337261746285

c69

c69

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
653.9786697887325, 1029.5838051064927

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 890.6575959492214

c70

c70

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
619.0, 912.0

c71

c71

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
619.0, 917.0

c72

c72

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
619.0, 922.0

c73

c73

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
552.0, 957.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 947.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 894.0

c76

c76

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
562.4654160868196, 1092.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.6568542494924, 1137.6568542494924

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.4498455671969, 1092.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 841.3552049089658

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 1140.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 1196.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0, 1195.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.0, 723.9990678163566

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.0, 723.3351878107351

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.0, 344.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 350.38862852649766

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 344.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 888.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.5538553641523, 897.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 850.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 344.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.7585526044338, 300.2804166494748

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.0, 270.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.9592937412584, 290.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 273.47440140654027

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 256.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.3596099683606, 268.85338655480155

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0, 256.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 256.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
290.0, 344.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back