1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16006187.csml convertedTime:2009.07.01.10:52

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaBpathway.
Authors Moynagh PN.
Affiliation Department of Pharmacology, Conway Institute of Biomolecular and BiomedicalResearch, University College Dublin, Belfield, Dublin 4, Ireland.P.Moynagh@ucd.ie
Abstract Toll-like receptors (TLRs) are crucially important in the sensing of infectiousagents. They serve to recognize pathogen-associated molecules and respond bytriggering the induction of specific profiles of proteins that are tailored tothe successful removal of the invading pathogens. The induction ofTLR-responsive genes is mediated by the activation of transcription factors, andmost interest has focussed on NF-kappaB, a transcription factor that isuniversally used by all TLRs. However, there has recently been a burgeoningeffort to increase our appreciation of the importance of members of theinterferon-regulatory factor (IRF) family in TLR signalling. This review willdiscuss the most recent findings relating to the regulation of IRF activity byTLRs and will highlight the rapidly increasing complexity of TLR signallingpathways.
PMID 16006187
Model Abstract

Entity

G010228:IFN-beta G010713:IRF-7 MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000065:RIP1 MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000218:26S proteasome MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016882:LPS MO000017462:CBP MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000019406:Tollip MO000019984:p300 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11:IRAK1 e12:LPS:TLR4:MYD88:Tollip e13:LPS:TLR4:MYD88:Tollip:IRAK1 e14:LPS:TLR4:MYD88:tollip:IRAK1:IRAK4 e15:LPS:TLR4:MYD88:Tollip:IRAK1{p}:IRAK4 e16:LPS:TLR4:MYD88:Tollip:IRAK1{p}:IRAK4 e17:LPS:TLR4:TRAM e18:MYD88:Tollip e19:LPS:TLR4:IRAK1{p}:IRAK4 e2: e20:MYD88:Tollip:TRAF6 e21:TAK1{active} e22:IKK-alpha{active} e23:IkappaB:NFkappaB e24:IkappaB{p}:NFkappaB e25:IkappaB{p}{ub}:NFkappaB e26:protein remnants e27:NF-kappaB e28:dsRNA:TLR3{p}:PI3K e29:IKK-beta{active} e3: e30:LPS:TLR4:TIRAP e31: e32: e33: e34:LPS:TLR4:TRAM:TRIF e35:LPS:TLR4:TRAM:TRIF:TRAF6 e36:LPS:TLR4:TRAM:TRIF:RIP1 e37:IRF-3 e38:(IRF3{p})2 e39:IRF3{p}:CBP e4: e40:IRF3{p}:p300 e41:IFN-beta e42:ISGF3{active} e43:ISGF3 e44:IFN-betaR e45:IFN-beta:IFNbetaR e46:IFN-alpha e47:IRF-3{p} e48:NAP1 e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:TLR4:TIRAP:MYD88 e60: e61: e62: e63:NF-kappaB{p} e64:dsRNA:TLR3{p} e65:AKT{active} e66:ssRNA e67:ssRNA:TLR7 e68:CpG DNA:TLR9 e69:CpG DNA e7: e70:ssRNA:TLR7:MYD88 e71:ssRNA:TLR7:MYD88:IRF7 e72:ssRNA:TLR7:MYD88:IRF7:IRAK4:TRAF6 e73:IRAK1:IRF7 e74:IRF-7{p} e75:MYD88:TRAF6:IRF5 e76:IRF-5{p} e77:IRF-5 e78:dsRNA:TLR3:TRIF:TBK1:IKK-i:NAP1 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p42 p44 p45 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p62 p63 p64 p65 p7 p8 p9
Model Detail
562.0, 1278.0
34.0, 34.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30 p37

p31

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
530.0, 1342.0
42.0, 42.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34

p35

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
935.0, 603.0
32.0, 32.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1029.0, 489.0
40.0, 40.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
959.0, 1255.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p15 p44

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1027.0, 195.0
32.0, 32.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1103.0, 1031.0
32.0, 32.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1219.0, 1023.0
40.0, 40.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
1230.0, 798.0
42.0, 42.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p23 p56 p60

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1046.0, 1078.0
34.0, 34.0

26S proteasome

--

MO000000218

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m189

10

false

infinite

0

unit false false false
TRANSPATHMO000000218

--

Go back
257.0, 357.0
36.0, 36.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60 p62 p63 p65

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
248.0, 1031.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p54 p57 p58 p45 p36

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1231.0, 303.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p53 p60 p65

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1119.0, 859.0
32.0, 32.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
838.0, 370.0
36.0, 36.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1508.0, 134.5
31.5, 31.5

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
442.0, 1050.0
26.0, 26.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
713.0, 373.0
38.0, 38.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1302.0, 130.5
33.5, 33.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
831.0, 599.0
32.0, 32.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1253.0, 363.0
30.0, 30.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
671.0, 1095.0
24.0, 24.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
858.0, 534.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1253.0, 237.0
28.0, 28.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1234.0, 544.0
36.0, 36.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p56

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1149.0, 201.0
36.0, 36.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p22

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1218.0, 194.0
34.0, 34.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
758.0, 498.0
36.0, 36.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p64

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
805.0, 549.0
38.0, 38.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p20 p47 p25 p36

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
615.0, 979.0
31.0, 31.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27 p28 p29 p30

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
246.0, 821.0
38.0, 38.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p45 p36

p37 p38 p59

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
676.0, 828.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
780.0, 812.0
31.0, 31.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
125.24885983960058, 101.87617432960297
1250.041303778392, 1815.059973086224

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
154.8688506635558, 146.03491015736859
967.8032579424308, 1361.427052582127

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1211.0, 459.9399999999998
42.08, 31.560000000000002

IRAK1

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p57 p58

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1307.0, 405.2058823529412
34.6764705882353, 57.794117647058826

LPS:TLR4:MYD88:Tollip

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1308.0, 499.5
31.49999999999999, 52.5

LPS:TLR4:MYD88:Tollip:IRAK1

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1307.0, 576.5
25.5, 42.50000000000001

LPS:TLR4:MYD88:tollip:IRAK1:IRAK4

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1306.0, 630.9411764705883
28.235294117647058, 47.05882352941177

LPS:TLR4:MYD88:Tollip:IRAK1{p}:IRAK4

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p7

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1307.0, 692.0588235294118
31.764705882352935, 52.94117647058824

LPS:TLR4:MYD88:Tollip:IRAK1{p}:IRAK4

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1191.5, 125.23251972839051
30.65002752798679, 42.76748027160948

LPS:TLR4:TRAM

--

e17

cso30:c:Complex

cso30:i:CC_Extracellular

--

p21

p22

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1220.0, 729.1823204419888
38.53591160220995, 42.81767955801105

MYD88:Tollip

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1308.0, 762.1470588235295
29.91176470588235, 49.852941176470594

LPS:TLR4:IRAK1{p}:IRAK4

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
125.24885983960058, 101.87617432960297
1250.041303778392, 1815.059973086224

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1238.5, 860.479721049734
32.62286658102404, 45.5202789502661

MYD88:Tollip:TRAF6

--

e20

cso30:c:Complex

cso30:i:CC_Cell

--

p9

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1159.0, 995.0
32.0, 32.0

TAK1{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11 p17

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1123.0, 1163.0
32.0, 32.0

IKK-alpha{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p12

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1029.5, 794.3469421763041
34.016663889351776, 41.653057823696045

IkappaB:NFkappaB

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p12 p16

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
970.5, 938.6168971838026
33.796200633227784, 41.38310281619729

IkappaB{p}:NFkappaB

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12 p16

p13

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
972.5, 1136.3574404265958
36.458090318280284, 44.64255957340444

IkappaB{p}{ub}:NFkappaB

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1025.0, 1293.3653072946581
27.55313038483631, 26.634692705341774

protein remnants

--

e26

cso30:c:EntityBiological

cso30:i:CC_Cell

--

p14

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
815.0, 1207.0
32.0, 32.0

NF-kappaB

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p30

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
836.0, 698.414364640884
31.127071823204417, 34.58563535911602

dsRNA:TLR3{p}:PI3K

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p49

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1211.0, 1143.0
40.0, 40.0

IKK-beta{active}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p16

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
150.24968591516853, 126.8770004051708
1200.0396516272558, 1765.0583209350882

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1311.5, 256.7790420260598
31.69168654799046, 44.22095797394018

LPS:TLR4:TIRAP

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p2

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
648.0223958432102, 500.9433561526937
215.7444484478406, 360.1835283408868

--

e31

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false true false

--

Go back
648.0223958432102, 500.9433561526937
215.7444484478406, 360.1835283408868

--

e32

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false true false

--

Go back
648.0223958432102, 500.9433561526937
215.7444484478406, 360.1835283408868

--

e33

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false true false

--

Go back
1121.0, 124.26470588235287
27.441176470588236, 45.73529411764706

LPS:TLR4:TRAM:TRIF

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23 p24

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1068.0, 121.85294117647058
30.088235294117638, 50.14705882352941

LPS:TLR4:TRAM:TRIF:TRAF6

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
980.0, 126.61764705882354
29.029411764705884, 48.38235294117647

LPS:TLR4:TRAM:TRIF:RIP1

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
240.0, 616.0
30.0, 30.0

IRF-3

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p50 p42 p25

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
725.5, 1001.8256957173805
27.9090151641393, 34.17430428261956

(IRF3{p})2

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
617.5, 1102.995500749875
26.953674387602064, 33.00449925012497

IRF3{p}:CBP

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
196.5012141549687, 170.62844603741428
1107.5365951476551, 1677.5554296706011

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
751.0, 1074.3093922651935
23.12154696132598, 25.690607734806626

IRF3{p}:p300

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1431.0, 1355.6855504125579
48.347756087744, 29.81444958744214

IFN-beta

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

p33

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
853.5, 1462.1653514406314
34.998164800880886, 48.8346485593687

ISGF3{active}

--

e42

cso30:c:Complex

cso30:i:CC_Cell

--

p32

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
763.5, 1541.8051018535514
30.239677004955034, 42.19489814644889

ISGF3

--

e43

cso30:c:Complex

cso30:i:CC_Cell

--

--

p32

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1310.5, 1401.506151142355
33.471001757469246, 51.49384885764499

IFN-betaR

--

e44

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p33

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1311.5, 1473.0
31.0, 60.0

IFN-beta:IFNbetaR

--

e45

cso30:c:Complex

cso30:i:CC_Cell

--

p33

p32

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
398.0, 1241.0380622837372
50.55363321799308, 26.961937716262977

IFN-alpha

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38 p55

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
487.0, 673.0
31.0, 31.0

IRF-3{p}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p50 p42 p25

p26

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
779.5, 371.90923727108066
25.339303682833563, 41.0907627289193

NAP1

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p64

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1308.5, 182.26244244683187
29.314404735803553, 56.737557553168166

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p19 p21 p39

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
347.59714309316314, 928.9444368386737
542.9756860548508, 492.41929070523764

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
406.2425616987149, 940.614058163339
317.49416279557414, 477.2523721003535

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
354.67503844210916, 935.5167682341232
528.8198953569594, 479.27462791433777

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
355.6861663491012, 936.5278961411159
526.7976395429746, 477.2523721003535

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
347.59714309316314, 928.9444368386737
542.9756860548508, 492.41929070523764

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
347.59714309316314, 928.9444368386737
542.9756860548508, 492.41929070523764

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
355.6861663491012, 936.5278961411159
526.7976395429746, 477.2523721003535

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
743.9592826341336, 1131.1700182371274
33.92213748258804, 30.70846130002711

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
654.9800268188137, 1272.7279252160474
96.05715116426597, 86.95700000133562

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
347.59714309316314, 928.9444368386737
542.9756860548508, 492.41929070523764

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1308.5, 322.67700495503766
28.8981464488897, 40.32299504496237

LPS:TLR4:TIRAP:MYD88

--

e6

cso30:c:Complex

cso30:i:CC_Extracellular

--

p2

p3 p63

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
475.573457182394, 1147.7715007339864
17.19524215839246, 8.279190668855637

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
474.9992593741896, 1123.0809949811912
58.85527534096534, 105.93949561373759

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
499.6897651269853, 1191.9847319657365
9.187164931272633, 9.187164931272637

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
849.0, 973.4878048780488
44.39024390243903, 35.51219512195122

NF-kappaB{p}

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
837.0, 645.2682926829268
43.41463414634146, 34.731707317073166

dsRNA:TLR3{p}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1043.0, 635.0
40.0, 40.0

AKT{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p50

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
792.0, 896.7896294672221
53.63297522473142, 27.710370532777898

ssRNA

--

e66

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
824.5, 742.6176277132208
29.130892348169258, 56.382372286779216

ssRNA:TLR7

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p53

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
642.5, 733.5904406928305
27.07827230870423, 52.40955930716948

CpG DNA:TLR9

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p65

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
525.0, 852.5
60.0, 13.0

CpG DNA

--

e69

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
155.36702914499415, 133.71007724398987
1215.0624907415054, 1721.712164002723

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
739.5, 825.485777206827
30.46852633510736, 42.51422279317306

ssRNA:TLR7:MYD88

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
648.0, 654.4411764705883
29.735294117647058, 49.55882352941177

ssRNA:TLR7:MYD88:IRF7

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55 p56

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
643.0, 605.4411764705883
26.73529411764706, 44.55882352941177

ssRNA:TLR7:MYD88:IRF7:IRAK4:TRAF6

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
321.0, 783.1049723756906
35.005524861878456, 38.89502762430941

IRAK1:IRF7

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
560.0, 996.0
38.0, 38.0

IRF-7{p}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

--

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
426.5, 256.8541016700312
32.35456046981096, 45.145898329968816

MYD88:TRAF6:IRF5

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
255.0, 507.65853658536594
47.92682926829268, 38.34146341463415

IRF-5{p}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
525.0, 1113.0
36.0, 36.0

IRF-5

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63 p65

--

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
706.0, 490.0
36.0, 36.0

dsRNA:TLR3:TRIF:TBK1:IKK-i:NAP1

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

p44 p42 p45 p62

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
141.86520762643244, 132.19732661405794
939.3273706528274, 1363.9033421879053

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
151.19368357693452, 156.6845759841258
935.0388259524282, 1346.0160916183654

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1408.0, 138.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 16006187

Go back
1163.0, 931.0
23.0, 23.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m1573*m20*0.1

nodelay

--

true

0

false

PMID: 16006187, 10094049 TRAF-6 is an ubiquitin ligase and activates transforming growth factor-¦Â (TGF-¦Â)-activating kinase (TAK1).

Go back
1140.0, 1096.0
21.0, 21.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e21 MO000000210

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c34 : 1
stoichiometry:c43 : 1

m21*m181*0.1

nodelay

--

true

0

false

PMID: 16006187 TAK1 promotes downstream activation of the I¦ÊB kinases (IKK), IKK alpha and IKK¦Â.

Go back
974.0, 878.0
25.0, 25.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c44 : 1
stoichiometry:c33 : 1

m23*m22*0.1

nodelay

--

true

0

false

PMID: 16006187, 9570540 The IKKs directly phosphorylate members of the inhibitory I¦ÊB family, which normally sequester NF-¦ÊB in an inactive form in the cytosol.

Go back
1008.0, 1044.0
22.0, 22.0

p13

p13

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 16006187, 9237759, 12467243 The phosphorylation of the I¦ÊB proteins represents a signal for polyubiquitination followed by their degradation by the 26 S proteosome and this enables the translocation of NF-¦ÊB to the nucleus, where it induces a plethora of genes encoding proinflammatory proteins and co-stimulatory molecules.

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1027.0, 1219.0
23.0, 23.0

p14

p14

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e25 MO000000218

e26 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c42 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m25*m189*0.1

nodelay

--

true

0

false

PMID: 16006187, 9237759, 12467243 The phosphorylation of the I¦ÊB proteins represents a signal for polyubiquitination followed by their degradation by the 26 S proteosome and this enables the translocation of NF-¦ÊB to the nucleus, where it induces a plethora of genes encoding proinflammatory proteins and co-stimulatory molecules.

Go back
908.0, 1212.0
21.0, 21.0

p15

p15

cso30:i:ME_Translocation

cso30:i:CC_Cell

--

MO000000058

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16006187, 9237759, 12467243 The phosphorylation of the I¦ÊB proteins represents a signal for polyubiquitination followed by their degradation by the 26 S proteosome and this enables the translocation of NF-¦ÊB to the nucleus, where it induces a plethora of genes encoding proinflammatory proteins and co-stimulatory molecules.

Go back
1051.0, 891.0
23.0, 23.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 e29

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c48 : 1
stoichiometry:c30 : 1

m23*m30*0.1

nodelay

--

true

0

false

PMID: 16006187, 9570540 The IKKs directly phosphorylate members of the inhibitory I¦ÊB family, which normally sequester NF-¦ÊB in an inactive form in the cytosol.

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1223.0, 1091.0
23.0, 23.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000211 e21

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m182*m21*0.1

nodelay

--

true

0

false

PMID: 16006187 TAK1 promotes downstream activation of the I¦ÊB kinases (IKK), IKK alpha and IKK¦Â.

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927.0, 567.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cell

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16006187 Poly(I:C) is ligand for TLR3.

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1412.0, 212.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000022528

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m5*m6810*0.1

nodelay

--

true

0

false

PMID: 16006187, 12447442, 12447441 TIRAP acts as a bridging adaptor between Myd88 and TLR4 and TLR2.

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1448.0, 268.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e30

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c51 : 1
stoichiometry:c6 : 1

m1572*m31*0.1

nodelay

--

true

0

false

PMID: 16006187, 9734363 All TLRs recruit the TIR domain-containing adaptor molecule myeloid differentiation factor 88 (Myd88).

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813.0, 477.0
20.0, 20.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16006187, 12539043 TRIF interacts directly with the TIR domain of TLR3.

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1269.0, 41.0
27.0, 27.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000041132

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m5*m19005*0.1

nodelay

--

true

0

false

PMID: 16006187, 14519765 TIR domain-containing adaptor TRIF-related adaptor molecule (TRAM), also known as TICAM-2, acts as a bridging adaptor between TLR4 and TRIF.

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1156.0, 32.0
21.0, 21.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000041125

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m17*m18998*0.1

nodelay

--

true

0

false

PMID: 16006187, 14519765 TIR domain-containing adaptor TRIF-related adaptor molecule (TRAM), also known as TICAM-2, acts as a bridging adaptor between TLR4 and TRIF.

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1144.0, 364.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e34 MO000000212

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m35*m183*0.1

nodelay

--

true

0

false

PMID: 16006187 TRIF interacts with TRAF-6, the downstream adaptor with a previously described role in the Myd88-dependent pathway.

Go back
1032.0, 24.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e34 MO000000065

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m35*m37*0.1

nodelay

--

true

0

false

PMID: 16006187, 15064760 TRIF can also associate with the kinase receptor-interacting protein 1 (RIP1) and can activate NF-¦ÊB.

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428.0, 616.0
23.0, 23.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041446 e37

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m19314*m39*0.1

nodelay

--

true

0

false

PMID: 16006187 Viral infection triggers phosphorylation of a serine/threonine cluster in the C-terminal region of IRF3. PMID: 16006187, 11698465, 12354379, 12524442 The engagement of TLR3 and TLR4 by poly(I:C) and LPS, respectively, promotes phosphorylation of IRF3 and the induction of type I IFN genes.

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593.0, 749.0
19.0, 19.0

p26

p26

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e47

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c106 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 16006187 IRF3 shuttles into the nucleus by virtue of its nuclear localisation sequence. PMID: 16006187, 14679297 IKK-i and TBK1 can directly phosphorylate IRF3 at its C-terminal serine/threonine cluster and that this is sufficient to induce nuclear translocation and DNA binding of IRF-3.

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676.0, 984.0
21.0, 21.0

p27

p27

cso30:i:ME_Dimerization

cso30:i:CC_Nucleoplasm

--

MO000041456

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16006187 Phosphorylation causes a change in conformation, revealing an IRF-association domain and DNA-binding domain, enabling the dimerization of IRF3 and binding to IRF3 motifs in relevant promoters.

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621.0, 1053.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000041456 MO000017462

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m19324*m2282*0.1

nodelay

--

true

0

false

PMID: 16006187 The C-terminal phosphorylation of IRF3 also facilitates its association with the co-activators CBP [CREB (cAMP response element-binding protein)-binding protein] and p300 and these interactions prevent IRF3 export to the cytoplasm.

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672.0, 1039.5
22.5, 22.5

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041456 MO000019984

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m19324*m4512*0.1

nodelay

--

true

0

false

PMID: 16006187 The C-terminal phosphorylation of IRF3 also facilitates its association with the co-activators CBP [CREB (cAMP response element-binding protein)-binding protein] and p300 and these interactions prevent IRF3 export to the cytoplasm.

Go back
1430.0, 367.5
20.5, 20.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000019406

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6*m3973*0.1

nodelay

--

true

0

false

PMID: 16006187, 10854325 IRAK-1 is recruited to Myd88 within a complex with another protein termed Toll-interacting protein (Tollip).

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566.0, 1186.0
25.0, 25.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456 e27

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c83 : 1

m19324*m28*0.1

nodelay

--

true

0

false

PMID: 16006187 IRF3 primarily activates the IFN-¦Â promoter with the co-operation of other transcription factors, especially NF-¦ÊB.

Go back
869.0, 1360.5
20.5, 20.5

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010228

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16006187 IRF3 primarily activates the IFN-¦Â promoter with the co-operation of other transcription factors, especially NF-¦ÊB.

Go back
859.0, 1551.0
24.0, 24.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e43 e45

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c93 : 1
stoichiometry:c89 : 1

m45*m47*0.1

nodelay

--

true

0

false

PMID: 16006187 Once IFN-¦Â is produced, it subsequently activates a transcription factor complex, known as IFN-stimulated gene factor 3 (ISGF3), comprising STAT1 (signal transducer and activator of transcription1), STAT2 and IRF9.

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1391.0, 1415.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e44 e41

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m46*m43*0.1

nodelay

--

true

0

false

PMID: 16006187 IFN-beta binds IFN-beta receptor.

Go back
634.0, 1350.0
25.0, 25.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 16006187 ISGF3 in turn induces the expression of IRF7 and this is subject to virus-induced phosphorylation in a manner similar to IRF3.

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351.0, 1347.0
23.0, 23.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010713

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m93631*0.1

nodelay

--

true

0

false

PMID: 16006187 ISGF3 in turn induces the expression of IRF7 and this is subject to virus-induced phosphorylation in a manner similar to IRF3.

Go back
280.0, 956.0
24.0, 24.0

p36

p36

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000041446

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m980*m19314*0.1

nodelay

--

true

0

false

PMID: 16006187 ISGF3 in turn induces the expression of IRF7 and this is subject to virus-induced phosphorylation in a manner similar to IRF3.

Go back
491.0, 1167.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16006187 This leads to activation of IRF7 and its stimulation of IFN-alpha/¦Â promoters.

Go back
387.0, 1115.0
25.0, 25.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16006187 This leads to activation of IRF7 and its stimulation of IFN-alpha/¦Â promoters.

Go back
485.0, 761.0
21.0, 21.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e37 e5

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c73 : 1

m39*m5*0.1

nodelay

--

true

0

false

PMID: 16006187, 11698465, 12354379, 12524442 The engagement of TLR3 and TLR4 by poly(I:C) and LPS, respectively, promotes phosphorylation of IRF3 and the induction of type I IFN genes.

Go back
1412.0, 466.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m11*0.1

nodelay

--

true

0

false

PMID: 16006187, 10854325 IRAK-1 is recruited to Myd88 within a complex with another protein termed Toll-interacting protein (Tollip).

Go back
335.0, 645.0
23.0, 23.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37 e78

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c191 : 1
stoichiometry:c117 : 1

m39*m82*0.1

nodelay

--

true

0

false

PMID: 16006187 IKK-i and TBK1 can directly phosphorylate IRF3 at its C-terminal serine/threonine cluster.

Go back
935.0, 1026.5
24.5, 24.5

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000058 e78

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c193 : 1
stoichiometry:c123 : 1

m27*m82*0.1

nodelay

--

true

0

false

PMID: 16006187, 10783893, 10990461 the overexpression of both forms is sufficient to activate NF-¦ÊB, this is independent of the phosphorylation and degradation of I¦ÊB proteins and is more related to the phosphorylation and increased transactivation of the NF-¦ÊB subunit p65.

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257.0, 928.0
23.0, 23.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e78

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c192 : 1
stoichiometry:c126 : 1

m980*m82*0.1

nodelay

--

true

0

false

PMID: 16006187, 12702806 IKK-i and TBK1 also phosphorylate and activate IRF7.

Go back
751.0, 659.0
25.0, 25.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041446

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 16006187 TLR3 has been shown recently to be phosphorylated on two key tyrosine residues in response to its engagement by dsRNA.

Go back
925.0, 713.0
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000000030

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m66*m29*0.1

nodelay

--

true

0

false

PMID: 16006187, 15502848 TLR3 has been shown recently to be phosphorylated on two key tyrosine residues in response to its engagement by dsRNA and this leads to the recruitment of phosphatidylinositol-3 kinase (PI3K), activation of the downstream kinase Akt and ultimately phosphorylation of IRF-3.

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1030.0, 570.0
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e28

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m68*m67*0.1

nodelay

--

true

0

false

PMID: 16006187, 15502848 TLR3 has been shown recently to be phosphorylated on two key tyrosine residues in response to its engagement by dsRNA and this leads to the recruitment of phosphatidylinositol-3 kinase (PI3K), activation of the downstream kinase Akt and ultimately phosphorylation of IRF-3.

Go back
1391.0, 549.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000039077

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m13*m17258*0.1

nodelay

--

true

0

false

PMID: 16006187, 12421671 Myd88 then associates with members of the IL-1R-associated kinase (IRAK) family (IRAK-1?4).

Go back
417.0, 537.0
21.0, 21.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e37 e65

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c140 : 1

m39*m69*0.1

nodelay

--

true

0

false

PMID: 16006187, 15502848 TLR3 has been shown recently to be phosphorylated on two key tyrosine residues in response to its engagement by dsRNA and this leads to the recruitment of phosphatidylinositol-3 kinase (PI3K), activation of the downstream kinase Akt and ultimately phosphorylation of IRF-3.

Go back
830.0, 821.5
18.5, 18.5

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m19940*m70*0.1

nodelay

--

true

0

false

PMID: 16006187, 14976262, 14976261, 11470918, 12900525 TLR7 and TLR9 strongly and produce large amounts of IFN-alpha in response to the TLR7 ligand, single stranded viral RNA and TLR9 activators, such as DNA viruses and CpG oligonucleotides.

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647.0, 879.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e69

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m19828*m73*0.1

nodelay

--

true

0

false

PMID: 16006187, 14976262, 14976261, 11470918, 12900525 TLR7 and TLR9 strongly and produce large amounts of IFN-alpha in response to the TLR7 ligand, single stranded viral RNA and TLR9 activators, such as DNA viruses and CpG oligonucleotides.

Go back
1130.0, 646.0
25.0, 25.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e67

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m1572*m71*0.1

nodelay

--

true

0

false

PMID: 16006187, 15361868, 15492225 Myd88 forms a complex with IRF7 to trigger its activation and induce IFN-alpha

Go back
704.0, 884.0
21.0, 21.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000007702

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m74*m980*0.1

nodelay

--

true

0

false

PMID: 16006187, 15361868, 15492225 Myd88 forms a complex with IRF7 to trigger its activation and induce IFN-alpha

Go back
433.0, 1181.0
19.0, 19.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e71

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 16006187, 15361868, 15492225 Myd88 forms a complex with IRF7 to trigger its activation and induce IFN-alpha

Go back
700.0, 632.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000000212 MO000039077

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m75*m183*m17258*0.1

nodelay

--

true

0

false

PMID: 16006187, 15492225, 15361868 This complex also contains IRAK4 and TRAF6 and the ubiquitin ligase activity of the latter is required for IRF activation.

Go back
454.0, 826.0
18.0, 18.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e11

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m980*m11*0.1

nodelay

--

true

0

false

PMID: 16006187, 15815647 IRAK-1 interacts directly with, and phosphorylates, IRF7.

Go back
348.0, 920.0
21.0, 21.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e11

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m980*m11*0.1

nodelay

--

true

0

false

PMID: 16006187, 15815647 IRAK-1 interacts directly with, and phosphorylates, IRF7.

Go back
464.0, 923.5
22.5, 22.5

p59

p59

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 16006187 TLR7 and TLR9 use a Myd88- and IRAK-1-dependent pathway to phosphorylate IRF7, leading to its nuclear translocation and the induction of type I IFN genes.

Go back
1399.0, 614.5
24.5, 24.5

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 16006187, 11960013, 8599092 The IRAK?Myd88 association triggers hyperphosphorylation of IRAK-1 by itself and other kinases, such as IRAK-4.

Go back
431.0, 364.0
23.0, 23.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 MO000000212 MO000016573

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1
stoichiometry:c171 : 1

m979*m183*m1572*0.1

nodelay

--

true

0

false

PMID: 16006187, 15665823 IRF5 associates with both Myd88 and TRAF-6.

Go back
340.0, 404.0
21.0, 21.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007700 e78

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c190 : 1
stoichiometry:c176 : 1

m979*m82*0.1

nodelay

--

true

0

false

PMID: 16006187, 15556946 IRF-5 is phosphorylated by TBK1 and IKK-i, this phosphorylation does not lead to IRF-5 nuclear translocation or activation.

Go back
373.0, 477.0
21.0, 21.0

p63

p63

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000007700 e6

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c187 : 1
stoichiometry:c179 : 1

m979*m6*0.1

nodelay

--

true

0

false

PMID: 16006187, 15665823 ligands for TLR4 and TLR9 promote nuclear translocation of IRF5 in a Myd88-dependent manner

Go back
754.0, 454.0
20.0, 20.0

p20

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000041437 MO000016608 e48

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m3902*m19305*m1599*m63*0.1

nodelay

--

true

0

false

PMID: 16006187, 12539043 TRIF interacts directly with the TIR domain of TLR3.

Go back
328.0, 531.5
22.5, 22.5

p65

p65

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000007700 e68 MO000016573

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c186 : 1
stoichiometry:c180 : 1
stoichiometry:c185 : 1

m979*m72*m1572*0.1

nodelay

--

true

0

false

PMID: 16006187, 15665823 ligands for TLR4 and TLR9 promote nuclear translocation of IRF5 in a Myd88-dependent manner

Go back
1414.0, 666.0
25.0, 25.0

p7

p7

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 16006187, 11960013, 8599092 The IRAK?Myd88 association triggers hyperphosphorylation of IRAK-1 by itself and other kinases, such as IRAK-4.

Go back
1402.0, 737.5
26.5, 26.5

p8

p8

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e16

e18 e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c20 : 1
stoichiometry:c22 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 16006187, 10854325 The IRAK?Myd88 association triggers hyperphosphorylation of IRAK-1 by itself and other kinases, such as IRAK-4 which leads to its dissociation from Myd88 and Tollip and its interaction with the downstream adaptor tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF-6)

Go back
1403.0, 807.0
23.0, 23.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000000212

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1

m18*m183*0.1

nodelay

--

true

0

false

PMID: 16006187, 10854325 The IRAK?Myd88 association triggers hyperphosphorylation of IRAK-1 by itself and other kinases, such as IRAK-4 which leads to its dissociation from Myd88 and Tollip and its interaction with the downstream adaptor tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF-6).

Go back
1336.0, 148.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1342.0, 442.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
310.392336367538, 582.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.0, 1190.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 859.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.0, 1140.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 859.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.0, 640.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.0, 768.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.6232259763574, 221.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1253.0, 476.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 635.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 659.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1347.194942833106, 484.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.9731121614235, 1058.9405952372156

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.8021211735029, 1009.2108369169304

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 958.9943809256735

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.3474977942105, 866.9924492668405

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1340.0, 533.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.0309682041927, 587.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 665.7831061593768

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 680.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.2164574740316, 635.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.9704381517995, 717.6871067372241

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1044.5838051064927, 529.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.0, 595.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 596.5578737618476

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.0, 556.479362905604

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.0, 562.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 558.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.88867064812223, 551.3299907538983

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.0, 829.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.0, 847.7690913781342

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 807.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.5174713247359, 860.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 866.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.1720032412167, 793.9981507165726

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1149.3371232616705, 335.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 666.773201126973

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1340.346592690932, 568.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.1949428331061, 665.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.3149107106393, 866.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 901.5674953863287

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.8588078368155, 711.781056061088

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.41795088587145, 1200.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.15879147762723, 704.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 655.8915800086061

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.6057429657127, 648.4804584131793

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.9113776687495, 565.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.72987951681, 634.0613012044827

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1333.0, 602.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 849.8567673908103

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.2489638428239, 486.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.73249246289424, 809.0514775921964

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 947.2469504755443

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.7459217823134, 863.5663617266162

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0937300253613, 487.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
284.0, 849.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.0, 944.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 375.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.98003289803034, 320.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1341.6786755654036, 631.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.01658874293514, 385.8428482161694

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 310.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 384.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.30551163022704, 425.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.0, 393.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 498.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1334.0, 657.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.7673304664697, 323.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
741.0, 411.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.9402850002907, 481.76114000116263

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.1615236461681, 403.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 393.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 554.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.60023958660497, 555.5207120456198

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.90667364736845, 345.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
770.9083398852216, 413.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.4715290310506, 474.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1346.4616246803494, 684.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.76246171842286, 418.934990457346

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.4366232265813, 515.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
285.79795622050455, 525.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0, 526.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1439.0, 150.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1267.0, 751.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1339.0, 725.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1345.451658795837, 756.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1259.0, 759.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1272.0, 819.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1278.4239284470364, 824.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.0, 891.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.0, 954.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.3855132026658, 895.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1051.0, 836.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1344.773092393688, 158.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.4817952863176, 912.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1155.9137853216664, 1027.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1001.9425724154552, 836.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 903.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1127.0, 1063.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 980.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.0956050533966, 1066.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 1181.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 1242.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
997.7415700784971, 1238.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1338.0, 213.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.145770236779, 1237.121475197316

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.0, 1223.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1042.398680883325, 1112.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1143.2035359758918, 1117.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.7505920311946, 910.0663328123957

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1236.5699763999032, 1063.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1232.550416732923, 1114.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1185.0, 1027.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1074.3423599403284, 920.7189217995622

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1281.0, 226.3834195432192

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.0, 282.4871333448388

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1349.9211200117202, 229.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1343.0, 279.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0, 586.9108042171238

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 558.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.9639637807517, 570.758472741024

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.1538177138508, 504.99852112023876

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.3126657865597, 233.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.7639112242477, 493.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.035946394237, 75.73659629810118

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.0, 75.64228712553077

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1344.2444551060582, 284.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1227.0714236390834, 68.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.8995700892397, 60.456037372330364

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1167.0, 61.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.367808234867, 53.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.0, 170.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.6852838107495, 392.8204743128039

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.4223508548341, 179.62444859226454

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.0856580228888, 51.1754418849364

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 53.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.0641201816035, 45.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1337.0, 347.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 628.1518713603775

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 639.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.90515772698393, 571.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.0, 711.9693977915938

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 700.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 995.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 1000.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 1010.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 1063.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 1072.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1283.0, 378.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 1010.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 1070.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 1056.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 1211.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.9817047516253, 1010.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
598.9650738084744, 1200.7467256695445

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.0, 1299.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
890.0, 1371.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 1563.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 1519.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1349.2198483022694, 383.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1344.0, 1427.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1419.4513482233508, 1386.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1348.5994286588773, 1438.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.9327001396418, 1505.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 1363.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0135207462929, 1373.8484447171966

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.99737144727584, 1359.2050608063405

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.40775615978237, 1072.6290700793104

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 987.5894663844041

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.6155024291795, 866.8351867815206

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back