1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16095970.csml convertedTime:2009.07.01.10:52

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Interferon gene regulation: not all roads lead to Tolls.
Authors Jefferies CA, Fitzgerald KA.
Affiliation Department of Biochemistry and Biotechnology Institute, Trinity College Dublin,Ireland.
Abstract Many infectious agents elicit a type I interferon response but, until recently,the molecular details that coordinate interferon (IFN)-alpha and -betaexpression during infection were unknown. Innate immune pattern recognitionreceptors, including Toll-like receptors and cytoplasmic RNA helicases such asretinoic acid-inducible gene, that sense viral nucleic acids have beendiscovered. Using distinct mechanisms, these receptors trigger cellularsignaling pathways, culminating in the activation of interferon regulatoryfactors that transcriptionally induce IFN-alpha and IFN-beta genes.
PMID 16095970
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010522:RANTES G010713:IRF-7 MO000000030:PI3K MO000000058:NF-kappaB MO000000060:MEKKs MO000000065:RIP1 MO000000212:TRAF6 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i {activated} MO000016660:IFNbeta MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016882:LPS MO000017462:CBP MO000019331:TBK1 {activated} MO000019394:TLR4 MO000019398:TLR3 MO000019984:p300 MO000022125:TAB2 MO000022136:Ubc13 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000066987:RIG-I MO000068831:MAL MO000103999:Mda-5 e1: e10: e11: e12: e13: e14: e15:ssRNA e16:dsDNA e17:ssRNA: TLR7 e18:ssRNA: TLR8 e19:dsDNA: TLR9 e2: e20:dsRNA: Mda-5 e21:dsRNA: RIG-I e22:dsRNA: PKR e23:IRF3{p}: IRF3 e24:IRF3 {p} e25:IRF3{p}: IRF3: CBP: p300 e26:IRF3{p}: IRF3: CBP: p300 {nucleus} e27:imidazoquinolines e28:imidazoquinolines: TLR7 e29:IFN-alpha e3: e30:ssRNA: TLR7: MyD88 e31:dsDNA: TLR9: MyD88 e32:IRF-7: MyD88 e33:IRAK1 e34:LPS: TLR4 e35:IRF-7 [p} e36:LPS: TLR4: MyD88: Mal e37:LPS: TLR4: TRIF: TIRAP e38:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4 e39:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A e4: e40:ssRNA: TLR7: MyD88: IRAK-1:IRAK-4 e41:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 e42:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)} e43:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1: TAB2: TAB3 e44:LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1{activated}: TAB2: TAB3 e45:IKK-alpha:IKK-beta:IKK-gamma {activated} e46:MEKKs {activated} e47:IRF-7: TRAF6 e48:Uev1 e49:dsDNA: TLR9: MyD88: IRAK-1: IRAK-4 e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:ssRNA: TLR7: MyD88: IRAK-1:IRAK-4: TRAF6 e64:dsDNA: TLR9: MyD88: IRAK-1: IRAK-4:TRAF6 e65:NF-kappaB {activated} e66:IRF-5 {activated} e67:IRF-5 {nucleus} e68:dsRNA:TLR3:TRIF: RIP1 e69:dsRNA:TLR3:TRIF: RIP1{ub} e7: e70:IKK-i e71:TBK1 e72:IP-10 e73:dsRNA: PKR {p} e74:dsRNA: RIG-I {activated} e75:V protein e76:V protein: Mda-5 e77:dsRNA: RIG-I {activated}: IKK-i: TBK1 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p8 p9
Model Detail
818.0, 1133.0
29.0, 29.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13 p20 p71

p59

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
618.0, 1330.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p64

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
556.0, 1280.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
532.0, 1171.0
34.5, 34.5

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
821.0, 1249.0
29.0, 29.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p60

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
671.0, 314.0
28.0, 28.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
791.0, 861.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p44 p45

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1016.0, 1027.0
34.0, 34.0

MEKKs

--

MO000000060

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000060

--

Go back
613.0, 552.0
23.0, 23.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
997.0, 557.0
29.0, 29.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p36 p41 p42 p54

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
558.0, 390.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p14 p15 p69

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
529.0, 777.0
30.0, 30.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p49 p52

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
847.0, 350.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p24 p36 p37 p38 p46 p47 p67

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
323.0, 190.0
28.0, 28.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
915.0, 514.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22 p23 p26

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1025.0, 736.0
39.0, 39.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
579.0, 259.0
25.0, 25.0

IKK-i {activated}

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p58

p9 p37

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
961.0, 1188.0
32.0, 32.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

p60

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1008.0, 907.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p68

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1226.0, 236.0
25.0, 25.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
622.0, 478.0
28.0, 28.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
615.0, 306.0
28.0, 28.0

TBK1 {activated}

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p57

p14 p38

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1162.0, 240.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
404.0, 592.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
725.0, 419.0
28.0, 28.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
984.0, 807.0
25.0, 25.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1100.0, 535.0
26.0, 26.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
166.0, 289.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p6 p7 p8

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1005.0, 181.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
959.0, 406.0
28.0, 28.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p39 p40

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
426.0, 334.0
27.0, 27.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p27

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
528.0, 572.0
32.0, 32.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p52 p53 p55 p57 p61 p62 p63 p64

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
471.0, 579.0
26.0, 26.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p1

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1040.0, 831.0
26.0, 26.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
383.0, 662.0
20.0, 20.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
468.0, 688.0
23.0, 23.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
418.0, 629.0
21.0, 21.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p16

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
318.0, 345.0
29.0, 29.0

RIG-I

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
1013.0, 253.0
30.0, 30.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
384.0, 340.0
23.5, 23.5

Mda-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p70

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
223.36507659866805, 99.08697584551494
994.7148426337714, 1444.3259515042357

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
232.9490848477258, 121.16282922711746
964.1832905378616, 1356.3347763228774

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
350.37601248614493, 580.9210687116913
469.5376100116545, 141.91812006783132

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
350.37601248614493, 580.9210687116913
469.5376100116545, 141.91812006783132

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
357.1699650425837, 587.7150212681302
455.9497048987771, 128.33021495495385

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
354.9053141904374, 585.4503704159835
460.4790066030698, 132.8595166592463

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
166.0, 588.0
34.930795847750865, 18.629757785467127

ssRNA

--

e15

cso30:c:mRNA

cso30:i:CC_Extracellular

--

--

p3 p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
161.5, 804.125
45.0, 15.75

dsDNA

--

e16

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
485.25, 621.0
15.5, 30.0

ssRNA: TLR7

--

e17

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

p5

p21

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
500.25, 665.0
15.5, 30.0

ssRNA: TLR8

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p51

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
556.25, 697.0
15.5, 30.0

dsDNA: TLR9

--

e19

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

p4

p22

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
223.36507659866805, 99.08697584551494
994.7148426337714, 1444.3259515042357

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
375.75, 389.0
24.5, 30.0

dsRNA: Mda-5

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p71

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
321.75, 439.0
28.329528411931342, 34.689218463589405

dsRNA: RIG-I

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p66

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
379.75, 237.0
24.5, 30.0

dsRNA: PKR

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p65

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
538.0, 446.75
35.28, 26.46

IRF3{p}: IRF3

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
664.0, 407.75
42.32, 31.74

IRF3 {p}

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9 p14 p15 p69

p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
872.25, 652.0
39.95788218021655, 55.755184437511474

IRF3{p}: IRF3: CBP: p300

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
807.25, 1061.0
39.95788218021655, 55.755184437511474

IRF3{p}: IRF3: CBP: p300 {nucleus}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13 p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
164.0, 704.0
41.2026913372582, 23.348191757779645

imidazoquinolines

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
539.375, 623.5
17.51353869765402, 33.89717167287875

imidazoquinolines: TLR7

--

e28

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p16

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
594.0, 1105.0
30.0, 30.0

IFN-alpha

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17 p18 p19

--

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
243.25937345134338, 118.98127269819037
954.9262489284205, 1404.537357798885

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
581.875, 620.5
27.90186272710589, 38.932831712240784

ssRNA: TLR7: MyD88

--

e30

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p21

p39

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
605.875, 688.5
27.37314186089191, 38.19508166636079

dsDNA: TLR9: MyD88

--

e31

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

p22

p40

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
972.625, 348.5
24.567363772704546, 30.082486252291282

IRF-7: MyD88

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
948.0, 282.0
30.0, 30.0

IRAK1

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p28 p39 p40

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000046974

--

Go back
1163.375, 290.5
23.25, 45.0

LPS: TLR4

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

p26 p27

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
779.5, 191.125
38.28, 28.70999999999999

IRF-7 [p}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24 p37 p38 p46 p47 p67

p18 p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1164.875, 393.5
32.25, 45.0

LPS: TLR4: MyD88: Mal

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p28

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1166.875, 162.5
32.25, 45.0

LPS: TLR4: TRIF: TIRAP

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p56 p58

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1158.875, 482.5
36.04574233804368, 50.29638465773536

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1162.875, 614.5
36.62181134153057, 51.10020187190311

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
280.0638226287933, 153.7962921903723
881.3173505735219, 1334.9073188145212

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
648.25, 611.0
24.340888236373644, 33.96403009726555

ssRNA: TLR7: MyD88: IRAK-1:IRAK-4

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p41

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1167.875, 721.5
32.25, 45.0

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1161.875, 792.5
39.15493668563039, 54.63479537529822

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p32

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1151.875, 874.5
42.61135070655166, 59.457698660304644

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1: TAB2: TAB3

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1151.875, 966.5
42.61135070655166, 59.457698660304644

LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1{activated}: TAB2: TAB3

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

p34 p35

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1008.0, 979.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p68

p43

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1088.0, 1091.0
34.0, 34.0

MEKKs {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000060

--

Go back
799.625, 395.5
27.629353441093148, 33.83186135644059

IRF-7: TRAF6

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1030.0, 501.0
30.0, 30.0

Uev1

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
HGNCUBE2V1
OMIM602995
ProteomeHumanPSD/UBE2V1
RefSeqNM_001032288
TRANSPATHMO000087842
UnigeneHs.420529
UniProtQ13404-1

--

Go back
674.25, 677.0
26.921361717746375, 37.56469076894843

dsDNA: TLR9: MyD88: IRAK-1: IRAK-4

--

e49

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p40

p42

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
358.67973227734797, 589.2247885028943
452.9301704292487, 125.31068048542545

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
429.66225707923314, 951.95902359883
495.88103267060285, 449.7096143586294

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
483.22110232112306, 962.616487684184
289.95650699919815, 435.858188865037

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
436.1262556429096, 957.9613079793868
482.95303554325034, 437.70504559751583

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
437.0496840091491, 958.8847363456259
481.10617881077115, 435.858188865037

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
429.66225707923314, 951.95902359883
495.88103267060285, 449.7096143586294

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
429.66225707923314, 951.95902359883
495.88103267060285, 449.7096143586294

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
437.0496840091491, 958.8847363456259
481.10617881077115, 435.858188865037

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
791.6461766451104, 1136.6446968467278
30.97992230090509, 28.044982293451003

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
710.3844804160358, 1265.9246681202546
87.72569479275093, 79.41483949659573

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
429.66225707923314, 951.95902359883
495.88103267060285, 449.7096143586294

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
350.37601248614493, 580.9210687116913
469.5376100116545, 141.91812006783132

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
546.5386263491721, 1151.8062602386697
15.703823684037612, 7.561100292314422

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
546.014231225408, 1129.2572699168113
53.750500185826574, 96.75090033448788

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
568.5632215472674, 1192.1846847685115
8.390321980226577, 8.390321980226586

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
701.25, 617.0
21.5, 30.0

ssRNA: TLR7: MyD88: IRAK-1:IRAK-4: TRAF6

--

e63

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulumLumen

--

p41

p44 p46 p48 p50

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
750.25, 676.0
28.81528720866214, 40.2073775004588

dsDNA: TLR9: MyD88: IRAK-1: IRAK-4:TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

p42

p45 p47 p49

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
795.0, 921.0
32.0, 32.0

NF-kappaB {activated}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43 p44 p45

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
522.0, 829.0
30.0, 30.0

IRF-5 {activated}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48 p49 p52

p50 p51

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
582.0, 1009.0
30.0, 30.0

IRF-5 {nucleus}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50 p51

p17

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
570.25, 480.0
22.31280968985135, 31.134153055606532

dsRNA:TLR3:TRIF: RIP1

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
684.25, 486.0
31.5299137456414, 43.99522848229033

dsRNA:TLR3:TRIF: RIP1{ub}

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
236.43417875647407, 104.89905765295883
975.5053585368878, 1382.2658954913843

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
471.0, 255.0
25.0, 25.0

IKK-i

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55 p58 p72

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
462.0, 306.0
28.0, 28.0

TBK1

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57 p72

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
546.0, 1229.0
30.0, 30.0

IP-10

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p62

--

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
438.75, 183.0
33.841109815030826, 41.43809365105815

dsRNA: PKR {p}

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
325.75, 487.0
28.329528411931342, 34.689218463589405

dsRNA: RIG-I {activated}

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p72

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
179.0, 226.5
26.400000000000002, 19.800000000000008

V protein

--

e75

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p70

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
379.5, 282.0
26.66788868521913, 32.654557573737705

V protein: Mda-5

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

p6

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
435.25, 482.0
25.635070655166086, 35.7698660304643

dsRNA: RIG-I {activated}: IKK-i: TBK1

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p67 p68 p69

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
239.9192726652223, 129.29471501419667
935.813914342284, 1358.8018036249964

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
249.21285642188434, 153.69037237543463
931.5414104971936, 1340.9814584553794

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
472.5, 492.5
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16095970, 12539043, 14517278 TLR3 signaling in response to the dsRNA mimetic polyinosinic?polycytidylic acid [poly (I-C)] can also activate IRF3, a process mediated solely by the Toll?interleukin (IL)-1 resistance or receptor (TIR)-domain-containing adaptor-inducing IFN-beta, TRIF.

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602.5, 422.5
27.0, 27.0

p10

p10

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 16095970, 8524823, 9463386, 11846977 In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300.

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679.5, 446.5
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000017462 MO000019984

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m23*m2282*m4512*0.1

nodelay

--

true

0

false

PMID: 16095970, 8524823, 9463386, 11846977 In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300.

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825.5, 995.5
27.0, 27.0

p12

p12

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 16095970 This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.

Go back
727.0, 1117.0
23.0, 23.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 16095970 This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.

Go back
616.5, 355.5
25.0, 25.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000019331

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c38 : 1

m977*m3902*0.1

nodelay

--

true

0

false

PMID: 16095970, 12702806, 14679297 Both kinases directly phosphorylate IRF3.

Go back
673.5, 368.5
23.0, 23.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000000030

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1

m977*m27*0.1

nodelay

--

true

0

false

PMID: 16095970, 15502848 Phosphatidylinositol 3-kinase has also been implicated in IRF3 activation and seems to be required for full activation of IRF3 following TLR3 signaling.

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379.5, 719.5
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000042126

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m28*m19940*0.1

nodelay

--

true

0

false

PMID: 16095970, 11812998 they produce large quantities of IFN-alpha and IFN-beta in response to purified ligands, including imidazoquinolines and ssRNA and for TLR7 or CpG oligonucleotides (CpG-ODNs), as well as certain microbial DNAs, in the case of TLR9.

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529.5, 1060.5
23.0, 23.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e67

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c47 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 16095970 IRF5 is also important for IFN-alpha induction.

Go back
513.5, 1108.5
23.0, 23.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c48 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16095970 IRF7 is essential for the induction of IFN-alpha and -beta genes via the MyD88-dependent TLR7 and 9 pathway.

Go back
654.5, 1097.5
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c49 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 16095970 This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.

Go back
321.5, 589.5
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 16095970, 11607032, 14976261, 11130078, Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.

Go back
730.5, 1153.5
21.0, 21.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c54 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16095970 IRF7 is essential for the induction of IFN-alpha and -beta genes via the MyD88-dependent TLR7 and 9 pathway.

Go back
791.5, 518.5
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016573

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c61 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 16095970, 11130078, 11812998 Upon binding of their ligands, TLR7 and TLR9 recruit myeloid differentiation factor-88 (MyD88) 6 and 44, which is essential for IFN induction by these TLRs.

Go back
784.5, 760.5
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e19

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c62 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 16095970, 11130078, 11812998 Upon binding of their ligands, TLR7 and TLR9 recruit myeloid differentiation factor-88 (MyD88) 6 and 44, which is essential for IFN induction by these TLRs.

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898.5, 353.5
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007702

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c63 : 1

m1572*m980*0.1

nodelay

--

true

0

false

PMID: 16095970, 15492225, 15361868 MyD88 interacts directly with IRF7 52 and 53 but not with IRF3.

Go back
849.5, 284.5
23.0, 23.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e33 MO000007702

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m34*m980*0.1

nodelay

--

true

0

false

PMID: 16095970, 8599092 IL-1 receptor-associated kinase (IRAK1), a kinase important for NF-kappaB signaling , is also important for IRF7 activation. PMID: 16095970 IRF7 must be phosphorylated on its carboxy-terminus to be activated.

Go back
1228.5, 290.5
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16095970, 10585427, 11896392 11698465 Lipopolysaccharide (LPS), via TLR4, triggers the nuclear translocation and DNA binding of IRF3 and subsequent induction of IFN-beta and IFN-stimulated genes.

Go back
1096.5, 304.5
23.0, 23.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e34 MO000068831

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m1572*m35*m43675*0.1

nodelay

--

true

0

false

PMID: 16095970 TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), Toll?IL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4.

Go back
1080.5, 220.5
23.0, 23.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000022528 MO000041125

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m35*m6810*m18998*0.1

nodelay

--

true

0

false

PMID: 16095970 TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), Toll?IL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4. PMID: 16095970 A fourth TIR-domain-containing adaptor, TRIF-related adaptor molecule, is required to recruit TRIF to the TLR4 cytoplasmic domain.

Go back
1096.5, 407.5
25.0, 25.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 e33 MO000039077

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m37*m34*m17258*0.1

nodelay

--

true

0

false

PMID: 16095970 TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), Toll?IL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4.

Go back
1102.5, 629.5
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 MO000022136 e48

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c83 : 1

m39*m6443*m63*0.1

nodelay

--

true

0

false

PMID: 16095970 For NF-kappaB activation, TRAF6 associates with a dimeric E2 (or ubiquitin conjugating enzyme), consisting of Ubc13 and Uev1A.

Go back
324.5, 696.5
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000042007

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m15*m19823*0.1

nodelay

--

true

0

false

PMID: 16095970, 11607032, 14976261, 11130078, Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.

Go back
1096.5, 699.5
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000000212

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m40*m183*0.1

nodelay

--

true

0

false

PMID: 16095970 For NF-kappaB activation, TRAF6 associates with a dimeric E2 (or ubiquitin conjugating enzyme), consisting of Ubc13 and Uev1A.

Go back
1096.5, 735.5
25.0, 25.0

p31

p31

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 16095970 A dimeric E2 (or ubiquitin-conjugating enzyme) consisting of Ubc13 and Uev1A polyubiquitinated target proteins, including TRAF6.

Go back
1101.5, 808.5
23.0, 23.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000022125 MO000041541 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m1573*m6433*m19389*m43*0.1

nodelay

--

true

0

false

PMID: 16095970, 15327770 K63-polyubiquintated TRAF6 mediates the activation of TAK1-associated proteins TAB2 and TAB3, which interact with K63?ubiquitin chains. PMID: 16095970, 15327770 In fact, the TAK1-associated proteins TAB2 and TAB3 both contain a domain that interacts specifically with K63?ubiquitin chains.

Go back
1080.5, 907.5
25.0, 25.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 16095970, 15327770 K63-polyubiquintated TRAF6 mediates the activation of TAK1-associated proteins TAB2 and TAB3, which interact with K63?ubiquitin chains.

Go back
1086.5, 985.5
26.0, 26.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000016661

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m45*m1637*0.1

nodelay

--

true

0

false

PMID: 16095970, 15361868 This model for TLR signaling predicts that the TAK1?TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex, as well as the JNK kinases (MEKKs).

Go back
1092.5, 1031.5
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000000060

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m45*m47*0.1

nodelay

--

true

0

false

PMID: 16095970, 15361868 This model for TLR signaling predicts that the TAK1?TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex, as well as the JNK kinases (MEKKs).

Go back
849.5, 400.5
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m183*m980*0.1

nodelay

--

true

0

false

PMID: 16095970 TRAF6 interacts with IRF7 via its RING finger domain.

Go back
809.5, 261.5
21.0, 21.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000016608

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c111 : 1
stoichiometry:c108 : 1

m980*m1599*0.1

nodelay

--

true

0

false

PMID: 16095970, 12702806, 15743772 This has been shown to occur through the action of IKKepsilon and/or TBK1, which can directly phosphorylate and activate IRF7.

Go back
788.5, 299.5
25.0, 25.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000019331

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c112 : 1
stoichiometry:c110 : 1

m980*m3902*0.1

nodelay

--

true

0

false

12702806, 15743772 This has been shown to occur through the action of IKKepsilon and/or TBK1, which can directly phosphorylate and activate IRF7.

Go back
773.5, 456.5
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 e30 MO000039077

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c119 : 1

m34*m31*m17258*0.1

nodelay

--

true

0

false

PMID: 16095970 IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.

Go back
439.5, 737.5
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000042012

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m16*m19828*0.1

nodelay

--

true

0

false

PMID: 16095970, 11607032, 14976261, 11130078, Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.

Go back
689.5, 792.5
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000039077 e31

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c120 : 1

m34*m17258*m32*0.1

nodelay

--

true

0

false

PMID: 16095970 IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.

Go back
881.5, 573.5
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e40

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m183*m41*0.1

nodelay

--

true

0

false

PMID: 16095970 IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.

Go back
824.5, 755.5
25.0, 25.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m183*m64*0.1

nodelay

--

true

0

false

PMID: 16095970 IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.

Go back
896.5, 926.5
21.0, 21.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e45

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c127 : 1
stoichiometry:c52 : 1

m67*m46*0.1

nodelay

--

true

0

false

PMID: 16095970 The IKK complex is then activated, leading to NF-kappaB activation.

Go back
712.5, 866.5
21.0, 21.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e63

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c133 : 1
stoichiometry:c129 : 1

m67*m65*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
744.5, 926.5
21.0, 21.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m67*m66*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
715.5, 318.5
27.0, 27.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e63

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m980*m65*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
754.5, 345.5
21.0, 21.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e64

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c137 : 1
stoichiometry:c139 : 1

m980*m66*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
600.5, 791.5
24.0, 24.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e63

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c144 : 1
stoichiometry:c141 : 1

m979*m65*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
604.5, 831.5
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e64

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c145 : 1
stoichiometry:c143 : 1

m979*m66*0.1

nodelay

--

true

0

false

PMID: 16095970 MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.

Go back
320.5, 620.5
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000042126

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m15*m19940*0.1

nodelay

--

true

0

false

PMID: 16095970, 11607032, 14976261, 11130078, Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.

Go back
583.5, 954.5
27.0, 27.0

p50

p50

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e66 e63

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m69*m65*0.1

nodelay

--

true

0

false

PMID: 16095970, 15695821 Engagement of TLR7 or 8 by R-848 results in IRF5 nuclear translocation.

Go back
476.5, 1011.5
25.0, 25.0

p51

p51

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e66 e18

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m69*m18*0.1

nodelay

--

true

0

false

PMID: 16095970, 15695821 Engagement of TLR7 or 8 by R-848 results in IRF5 nuclear translocation.

Go back
586.5, 753.5
24.0, 24.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 MO000041437

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m979*m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 IRF5 is activated in response to TLR3.

Go back
551.5, 530.5
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 MO000041437

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m71*m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 TLR3 uses RIP1, which might also be ubiquitinated by TRAF6.

Go back
606.5, 518.5
26.0, 26.0

p54

p54

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e68 MO000000212

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m72*m183*0.1

nodelay

--

true

0

false

PMID: 16095970 TLR3 uses RIP1, which might also be ubiquitinated by TRAF6.

Go back
541.5, 257.5
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 MO000041437

MO000016608

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c172 : 1
stoichiometry:c168 : 1

m74*m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.

Go back
516.5, 308.5
23.0, 23.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71 e37

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c174 : 1
stoichiometry:c166 : 1

m75*m38*0.1

nodelay

--

true

0

false

PMID: 16095970 Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.

Go back
475.5, 347.5
25.0, 25.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71 MO000041437

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c171 : 1
stoichiometry:c164 : 1

m75*m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.

Go back
579.5, 175.5
25.0, 25.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70 e37

MO000016608

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c173 : 1
stoichiometry:c170 : 1

m74*m38*0.1

nodelay

--

true

0

false

PMID: 16095970 Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.

Go back
965.5, 1136.5
23.0, 23.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c177 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16095970, 9786932, 9822609 The current dogma suggests that IRF3 mediates the early induction of IFN-beta, which then induces IRF7 via IFN-stimulated gene factor-3 signaling.

Go back
319.5, 303.5
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000103999 e76

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c203 : 1
stoichiometry:c18 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 16095970, 15208624, 15563593 Cytoplasmic RNA helicases, including retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene-5 (Mda-5) also bind dsRNA. PMID: 16095970 a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.

Go back
820.5, 1191.5
25.0, 25.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c176 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 16095970, 9786932, 9822609 The current dogma suggests that IRF3 mediates the early induction of IFN-beta, which then induces IRF7 via IFN-stimulated gene factor-3 signaling.

Go back
473.5, 1176.5
27.0, 27.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 16095970, 15731229 Rudd et al. found that respiratory syncytial virus-induced IFN-gamma-induced protein-10 (IP-10) and RANTES, but neither CXCL8 production nor viral replication, were impaired in the absence of TLR3.

Go back
488.5, 1231.5
25.0, 25.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 16095970, 15731229 Rudd et al. found that respiratory syncytial virus-induced IFN-gamma-induced protein-10 (IP-10) and RANTES, but neither CXCL8 production nor viral replication, were impaired in the absence of TLR3.

Go back
508.5, 1284.5
23.0, 23.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 A higher viral titer in the serum of TLR3-deficient mice was observed, and reduced levels of IL-6, TNF-alpha and IFN-beta detected in TLR3-deficient mice.

Go back
564.5, 1328.5
25.0, 25.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c185 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 16095970 A higher viral titer in the serum of TLR3-deficient mice was observed, and reduced levels of IL-6, TNF-alpha and IFN-beta detected in TLR3-deficient mice.

Go back
380.5, 192.5
23.0, 23.0

p65

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 16095970 The double-stranded RNA-activated protein kinase R (PKR) was the first of such cytoplasmic proteins described that could recognize and bind viral dsRNA. PMID: 16095970 PKR is activated by autophosphorylation upon binding to dsRNA.

Go back
375.5, 439.5
24.0, 24.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 16095970, 15208624 Yoneyama et al. showed that RIG-I binds dsRNA [poly (I-C)] via its RNA helicase domain and is activated by dsRNA.

Go back
723.5, 191.5
25.0, 25.0

p67

p67

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e77

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c199 : 1
stoichiometry:c192 : 1

m980*m81*0.1

nodelay

--

true

0

false

PMID: 16095970 It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.

Go back
954.5, 910.5
27.0, 27.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e77

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c210 : 1
stoichiometry:c195 : 1

m1637*m81*0.1

nodelay

--

true

0

false

PMID: 16095970 It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.

Go back
517.0, 421.0
22.0, 22.0

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e77

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c196 : 1
stoichiometry:c193 : 1

m977*m81*0.1

nodelay

--

true

0

false

PMID: 16095970 It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.

Go back
324.5, 400.5
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000066987

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 16095970, 15208624, 15563593 Cytoplasmic RNA helicases, including retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene-5 (Mda-5) also bind dsRNA.

Go back
325.0, 273.0
21.0, 21.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e75 MO000103999

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m79*m76904*0.1

nodelay

--

true

0

false

PMID: 16095970 a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.

Go back
741.0, 1197.0
25.0, 25.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 16095970 a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.

Go back
385.0, 493.0
21.0, 21.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 e74 e70

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c208 : 1

m75*m78*m74*0.1

nodelay

--

true

0

false

--

Go back
324.5, 240.5
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000008179

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 16095970 Protein kinase R, another cytosolic receptor for dsRNA has also been implicated in antiviral responses.

Go back
515.5, 355.5
25.0, 25.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016608

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c39 : 1
stoichiometry:c26 : 1

m977*m1599*0.1

nodelay

--

true

0

false

PMID: 16095970, 8524823, 9463386, 11846977 In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300. PMID: 16095970, 12702806, 14679297 Both kinases directly phosphorylate IRF3.

Go back
350.99034269649974, 600.3929676735984

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.0, 607.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.9921104517296, 997.3552049089658

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1124.535742906118, 1011.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1050.0, 1044.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0, 1057.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.5019571832863, 429.8076214712466

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 378.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 412.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.2693178820085, 290.30147660315225

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.365469824569, 227.64228712553077

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.009319187599, 328.28091686182944

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.6856438376102, 678.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.1999375292817, 227.997501171265

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 272.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
643.0, 313.3284898516168

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.751272537273, 311.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.0, 484.3795850425715

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.7554751503386, 424.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.6661305960369, 312.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.6206049297807, 434.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 724.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.9214425886477, 480.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.0, 682.2983455013672

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.017314527883, 722.9350533174868

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
910.9635820178842, 574.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 587.5038065552477

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.7347025773502, 587.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.332307672574, 586.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 702.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.6568542494924, 715.6568542494924

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.1554175279994, 945.5777087639997

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
742.0, 877.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.0, 884.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 753.8379018580156

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.191572848662, 893.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 937.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.3409222372328, 716.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.0, 647.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
128.9026346726248, 47.79676420646024

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 226.9932582089723

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.0, 353.98777335168296

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.0, 375.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.971586334859, 357.67365518322754

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.0, 227.79617108224915

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.07841912241383, 711.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.0, 795.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.1260949576658, 811.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 803.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 844.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.974267015324, 647.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.6333333299375, 711.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
108.81662137133009, 31.510594435920382

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 859.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 982.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.5813914223052, 647.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
463.0, 717.456022239382

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0707301793059, 859.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.0, 1024.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.42840648933645, 695.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
559.0, 775.3688904516371

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.3802853506394, 778.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.0, 604.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
559.0592796928046, 1037.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.4759018794317, 546.8479626207359

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 557.5183473879075

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 518.2953720414008

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.0, 305.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 506.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 515.2573305919324

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.9589879921499, 533.809018010191

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.0, 334.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 326.16205112102574

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.0, 320.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 320.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 268.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 269.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 201.7508183746969

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.96782774194344, 326.93056949545525

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 201.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.9127186026022, 380.76797963097613

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 286.9970196862651

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
591.9955574299361, 83.81153030990868

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.9194616863231, 68.10068180311755

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 1148.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.0, 1217.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1160.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.0, 1204.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
148.70544964941695, 495.52074879937027

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 329.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 1188.2579303520877

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.14703691475606, 472.0054122867873

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 1244.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
88.16336722633082, 567.5033374986921

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 1296.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 1342.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
67.67597667898025, 523.7513703324664

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.0, 224.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 204.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 453.6135719910779

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.0, 314.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.5402546255177, 464.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.9279104090704, 223.30203927313812

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 204.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 425.38355839494716

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
990.0, 924.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 938.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0, 446.20633098764773

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
545.7639112242477, 413.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.7915524685038, 135.6557862434924

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
189.0, 319.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 374.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 240.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.2494297193983, 300.036844177308

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 286.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.8460957905633, 302.0

c203

c203

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
766.0, 1164.9532362754983

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
47.840184135619666, 323.68031518550936

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.1847449441826, 334.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.0, 504.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 501.550416732923

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.81284036704534, 280.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 424.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
311.8401914205524, 504.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
196.0, 258.5298221281347

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.3474977942105, 218.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 252.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.1754418849364, 383.0856580228888

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 372.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.8782684705435, 427.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.4278135270821, 441.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 460.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 593.3745886903887

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
650.0, 471.7647058823529

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.8262546692157, 441.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 474.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.288510222449, 708.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.247700587784, 1023.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.2785523863447, 1098.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.0, 1131.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 380.1804964634343

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.0, 381.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.4376015698018, 284.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.0, 524.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 334.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0, 383.6883678680871

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.0, 392.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 342.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
205.0, 718.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.9711254108328, 650.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.0, 649.1008793404288

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 1080.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 1120.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.8035280165417, 1110.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 516.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.9409892248805, 1091.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
823.0, 887.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 937.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.7611400011626, 336.94028500029066

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.0, 1152.315191898443

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 533.6462699999144

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 528.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.8195678904774, 542.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 714.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.9711808528037, 382.94083167880717

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 361.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 364.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0275868750208, 533.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.5226729382948, 715.7220198131988

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 364.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.9992889836897, 296.1066571864492

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
861.0, 316.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.4845312952592, 226.62487577708748

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1239.0, 261.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.0, 263.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.8587085313798, 303.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
201.0, 601.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 334.1133192947361

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.9913606886246, 313.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 277.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 328.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1109.6568542494924, 248.65685424949237

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.0, 203.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.0, 231.82645590642448

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.0, 196.71205595736447

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.9913606886246, 417.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 310.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.9738323849174, 633.6465269501284

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 420.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.0, 433.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.4883669152746, 533.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1124.0, 640.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1113.0, 561.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 531.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.5882937983072, 658.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 586.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1122.0, 717.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.9924492668404, 745.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 632.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.0, 761.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 774.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 820.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 827.8995700892395

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 820.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.0, 832.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1113.8511412388802, 908.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.0, 932.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.9895013078128, 997.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1042.0, 941.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back