_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e14
_enti_e53
_enti_e59
_enti_e5
_enti_e12
_enti_e51
_enti_e50
_enti_e56
_enti_e54
_enti_e52
_enti_e11
_enti_e13
_enti_e6
_enti_e58
_enti_e61
_enti_e57
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g1
g1_fact_g3
p1_propro_p1
PMID: 16095970, 12539043, 14517278
TLR3 signaling in response to the dsRNA mimetic polyinosinicpolycytidylic acid [poly (I-C)] can also activate IRF3, a process mediated solely by the Tollinterleukin (IL)-1 resistance or receptor (TIR)-domain-containing adaptor-inducing IFN-beta, TRIF.
c4 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 16095970, 11607032, 14976261, 11130078,
Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 16095970, 11607032, 14976261, 11130078,
Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 16095970, 11607032, 14976261, 11130078,
Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 16095970, 11607032, 14976261, 11130078,
Toll-like receptors (TLRs) 3, 7, 8 and 9 are endosomally localized, membrane-bound receptors which recognize double-stranded (ds)RNA, single-stranded (ss)RNA and dsDNA, respectively.
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 16095970, 15208624, 15563593
Cytoplasmic RNA helicases, including retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene-5 (Mda-5) also bind dsRNA.
PMID: 16095970
a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c203 cso30:c:InputInhibitor connector
c18 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 16095970, 15208624, 15563593
Cytoplasmic RNA helicases, including retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene-5 (Mda-5) also bind dsRNA.
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 16095970
Protein kinase R, another cytosolic receptor for dsRNA has also been implicated in antiviral responses.
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16095970, 8524823, 9463386, 11846977
In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300.
PMID: 16095970, 12702806, 14679297
Both kinases directly phosphorylate IRF3.
c25 cso30:c:InputProcess connector
c39 cso30:c:InputAssociation connector
c26 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 16095970, 8524823, 9463386, 11846977
In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300.
c27 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 16095970, 8524823, 9463386, 11846977
In resting cells, IRF3 resides in the cytoplasm. Virus infection results in its signal-dependent phosphorylation, dimerization and interaction with the co-activator proteins CBP and p300.
c29 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c31 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 16095970
This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 16095970
This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.
c35 cso30:c:InputAssociation connector
c36 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 16095970, 12702806, 14679297
Both kinases directly phosphorylate IRF3.
c37 cso30:c:InputProcess connector
c40 cso30:c:InputAssociation connector
c38 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 16095970, 15502848
Phosphatidylinositol 3-kinase has also been implicated in IRF3 activation and seems to be required for full activation of IRF3 following TLR3 signaling.
c41 cso30:c:InputProcess connector
c43 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 16095970, 11812998
they produce large quantities of IFN-alpha and IFN-beta in response to purified ligands, including imidazoquinolines and ssRNA and for TLR7 or CpG oligonucleotides (CpG-ODNs), as well as certain microbial DNAs, in the case of TLR9.
c44 cso30:c:InputProcess connector
c45 cso30:c:InputProcess connector
c46 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 16095970
IRF5 is also important for IFN-alpha induction.
c156 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 16095970
IRF7 is essential for the induction of IFN-alpha and -beta genes via the MyD88-dependent TLR7 and 9 pathway.
c134 cso30:c:InputAssociation connector
c48 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 16095970
This IRF3-containing complex then translocates to the nucleus to regulate IFN-beta gene transcription.
c50 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 16095970
IRF7 is essential for the induction of IFN-alpha and -beta genes via the MyD88-dependent TLR7 and 9 pathway.
c146 cso30:c:InputAssociation connector
c54 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 16095970, 11130078, 11812998
Upon binding of their ligands, TLR7 and TLR9 recruit myeloid differentiation factor-88 (MyD88) 6 and 44, which is essential for IFN induction by these TLRs.
c55 cso30:c:InputProcess connector
c56 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 16095970, 11130078, 11812998
Upon binding of their ligands, TLR7 and TLR9 recruit myeloid differentiation factor-88 (MyD88) 6 and 44, which is essential for IFN induction by these TLRs.
c57 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c62 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 16095970, 15492225, 15361868
MyD88 interacts directly with IRF7 52 and 53 but not with IRF3.
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 16095970, 8599092
IL-1 receptor-associated kinase (IRAK1), a kinase important for NF-kappaB signaling , is also important for IRF7 activation.
PMID: 16095970
IRF7 must be phosphorylated on its carboxy-terminus to be activated.
c64 cso30:c:InputAssociation connector
c65 cso30:c:InputProcess connector
c66 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 16095970, 10585427, 11896392 11698465
Lipopolysaccharide (LPS), via TLR4, triggers the nuclear translocation and DNA binding of IRF3 and subsequent induction of IFN-beta and IFN-stimulated genes.
c67 cso30:c:InputProcess connector
c68 cso30:c:InputProcess connector
c69 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 16095970
TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), TollIL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4.
c70 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 16095970
TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), TollIL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4.
PMID: 16095970
A fourth TIR-domain-containing adaptor, TRIF-related adaptor molecule, is required to recruit TRIF to the TLR4 cytoplasmic domain.
c74 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 16095970
TLR4-induced activation of NF-kappaB occurs via the recruitment of MyD88-adapter-like (Mal), TollIL-1 receptor (TIR)-domain-containing adaptor protein (TIRAP) and MyD88, which then recruit the downstream serine/threonine kinases IRAK1 and 4.
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 16095970
For NF-kappaB activation, TRAF6 associates with a dimeric E2 (or ubiquitin conjugating enzyme), consisting of Ubc13 and Uev1A.
c82 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
c85 cso30:c:InputProcess connector
c83 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 16095970
For NF-kappaB activation, TRAF6 associates with a dimeric E2 (or ubiquitin conjugating enzyme), consisting of Ubc13 and Uev1A.
c86 cso30:c:InputProcess connector
c87 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16095970
A dimeric E2 (or ubiquitin-conjugating enzyme) consisting of Ubc13 and Uev1A polyubiquitinated target proteins, including TRAF6.
c89 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 16095970, 15327770
K63-polyubiquintated TRAF6 mediates the activation of TAK1-associated proteins TAB2 and TAB3, which interact with K63ubiquitin chains.
PMID: 16095970, 15327770
In fact, the TAK1-associated proteins TAB2 and TAB3 both contain a domain that interacts specifically with K63ubiquitin chains.
c91 cso30:c:InputProcess connector
c92 cso30:c:InputProcess connector
c93 cso30:c:InputProcess connector
c94 cso30:c:InputProcess connector
c95 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 16095970, 15327770
K63-polyubiquintated TRAF6 mediates the activation of TAK1-associated proteins TAB2 and TAB3, which interact with K63ubiquitin chains.
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 16095970, 15361868
This model for TLR signaling predicts that the TAK1TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex, as well as the JNK kinases (MEKKs).
c98 cso30:c:InputAssociation connector
c99 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 16095970, 15361868
This model for TLR signaling predicts that the TAK1TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex, as well as the JNK kinases (MEKKs).
c101 cso30:c:InputAssociation connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 16095970
TRAF6 interacts with IRF7 via its RING finger domain.
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 16095970, 12702806, 15743772
This has been shown to occur through the action of IKKepsilon and/or TBK1, which can directly phosphorylate and activate IRF7.
c107 cso30:c:InputProcess connector
c111 cso30:c:InputAssociation connector
c108 cso30:c:OutputProcess connector
p38_propro_p38
12702806, 15743772
This has been shown to occur through the action of IKKepsilon and/or TBK1, which can directly phosphorylate and activate IRF7.
c109 cso30:c:InputProcess connector
c112 cso30:c:InputAssociation connector
c110 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 16095970
IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.
c113 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c115 cso30:c:InputProcess connector
c119 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 16095970
IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.
c116 cso30:c:InputProcess connector
c117 cso30:c:InputProcess connector
c118 cso30:c:InputProcess connector
c120 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 16095970
IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.
c121 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 16095970
IRAK1, IRAK4 and TRAF6 also function downstream to mediate all of these events.
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 16095970
The IKK complex is then activated, leading to NF-kappaB activation.
c51 cso30:c:InputProcess connector
c127 cso30:c:InputAssociation connector
c52 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c128 cso30:c:InputProcess connector
c133 cso30:c:InputAssociation connector
c129 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c130 cso30:c:InputProcess connector
c132 cso30:c:InputAssociation connector
c131 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c53 cso30:c:InputProcess connector
c136 cso30:c:InputAssociation connector
c135 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c138 cso30:c:InputProcess connector
c137 cso30:c:InputAssociation connector
c139 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c140 cso30:c:InputProcess connector
c144 cso30:c:InputAssociation connector
c141 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 16095970
MyD88 interacts with, and is required for activation of, the transcription factors NF-kappaB, IRF5 and IRF7 in response to stimulation of TLR7- and TLR9-specific ligands.
c142 cso30:c:InputProcess connector
c145 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 16095970, 15695821
Engagement of TLR7 or 8 by R-848 results in IRF5 nuclear translocation.
c147 cso30:c:InputProcess connector
c149 cso30:c:InputAssociation connector
c148 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 16095970, 15695821
Engagement of TLR7 or 8 by R-848 results in IRF5 nuclear translocation.
c150 cso30:c:InputProcess connector
c152 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 16095970
IRF5 is activated in response to TLR3.
c153 cso30:c:InputProcess connector
c155 cso30:c:InputAssociation connector
c154 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 16095970
TLR3 uses RIP1, which might also be ubiquitinated by TRAF6.
c157 cso30:c:InputProcess connector
c158 cso30:c:InputProcess connector
c159 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 16095970
TLR3 uses RIP1, which might also be ubiquitinated by TRAF6.
c160 cso30:c:InputProcess connector
c162 cso30:c:InputAssociation connector
c161 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 16095970
Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.
c167 cso30:c:InputProcess connector
c172 cso30:c:InputAssociation connector
c168 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 16095970
Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.
c165 cso30:c:InputProcess connector
c174 cso30:c:InputAssociation connector
c166 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 16095970
Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.
c163 cso30:c:InputProcess connector
c171 cso30:c:InputAssociation connector
c164 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 16095970
Both TLR3- and TLR4-mediated activation of IRF3 and 7 and the induction of IFN-beta occur in a MyD88-independent manner and require TRIF and the IKK-related kinases IKKepsilon and TBK1.
c169 cso30:c:InputProcess connector
c173 cso30:c:InputAssociation connector
c170 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 16095970, 9786932, 9822609
The current dogma suggests that IRF3 mediates the early induction of IFN-beta, which then induces IRF7 via IFN-stimulated gene factor-3 signaling.
c175 cso30:c:InputAssociation connector
c177 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 16095970, 9786932, 9822609
The current dogma suggests that IRF3 mediates the early induction of IFN-beta, which then induces IRF7 via IFN-stimulated gene factor-3 signaling.
c178 cso30:c:InputAssociation connector
c176 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 16095970, 15731229
Rudd et al. found that respiratory syncytial virus-induced IFN-gamma-induced protein-10 (IP-10) and RANTES, but neither CXCL8 production nor viral replication, were impaired in the absence of TLR3.
c179 cso30:c:InputAssociation connector
c180 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 16095970, 15731229
Rudd et al. found that respiratory syncytial virus-induced IFN-gamma-induced protein-10 (IP-10) and RANTES, but neither CXCL8 production nor viral replication, were impaired in the absence of TLR3.
c181 cso30:c:InputAssociation connector
c182 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 16095970
A higher viral titer in the serum of TLR3-deficient mice was observed, and reduced levels of IL-6, TNF-alpha and IFN-beta detected in TLR3-deficient mice.
c183 cso30:c:InputAssociation connector
c184 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 16095970
A higher viral titer in the serum of TLR3-deficient mice was observed, and reduced levels of IL-6, TNF-alpha and IFN-beta detected in TLR3-deficient mice.
c186 cso30:c:InputAssociation connector
c185 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 16095970
The double-stranded RNA-activated protein kinase R (PKR) was the first of such cytoplasmic proteins described that could recognize and bind viral dsRNA.
PMID: 16095970
PKR is activated by autophosphorylation upon binding to dsRNA.
c187 cso30:c:InputProcess connector
c188 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 16095970, 15208624
Yoneyama et al. showed that RIG-I binds dsRNA [poly (I-C)] via its RNA helicase domain and is activated by dsRNA.
c189 cso30:c:InputProcess connector
c190 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 16095970
It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.
c191 cso30:c:InputProcess connector
c199 cso30:c:InputAssociation connector
c192 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 16095970
It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.
c194 cso30:c:InputProcess connector
c210 cso30:c:InputAssociation connector
c195 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 16095970
It is likely that a downstream effector CARD is then recruited to trigger the activation of IRF3 and IRF7, probably via IKK3, TBK1 and NF-kappaB activation via IKKalpha, beta and gamma.
c197 cso30:c:InputProcess connector
c196 cso30:c:InputAssociation connector
c193 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 16095970
a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.
c200 cso30:c:InputProcess connector
c201 cso30:c:InputProcess connector
c202 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 16095970
a highly conserved cysteine-rich carboxy-terminal region of paramyxovirus V proteins binds Mda-5, and in so doing inhibits dsRNAinduced IFN-beta production.
c205 cso30:c:InputAssociation connector
c204 cso30:c:OutputProcess connector
p72_propro_p72
c206 cso30:c:InputProcess connector
c207 cso30:c:InputProcess connector
c209 cso30:c:InputProcess connector
c208 cso30:c:OutputProcess connector
dsRNA_enti_MO000022224
dsRNA
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
dsRNA:TLR3:TRIF_enti_MO000041437
dsRNA:TLR3:TRIF
TLR3_enti_MO000019398
TLR3
TRIF_enti_MO000041125
TRIF
TLR7_enti_MO000042126
TLR7
ssRNA_enti_e15
ssRNA
dsDNA_enti_e16
dsDNA
TLR8_enti_MO000042007
TLR8
TLR9_enti_MO000042012
TLR9
ssRNA: TLR7_enti_e17
ssRNA: TLR7
ssRNA: TLR8_enti_e18
ssRNA: TLR8
dsDNA: TLR9_enti_e19
dsDNA: TLR9
RIG-I_enti_MO000066987
RIG-I
Mda-5_enti_MO000103999
Mda-5
dsRNA: Mda-5_enti_e20
dsRNA: Mda-5
dsRNA: RIG-I_enti_e21
dsRNA: RIG-I
PKR_enti_MO000008179
PKR
dsRNA: PKR_enti_e22
dsRNA: PKR
IRF-3_enti_MO000007694
IRF-3
IRF3 {p}_enti_e24
IRF3 {p}
IRF3{p}: IRF3_enti_e23
IRF3{p}: IRF3
p300_enti_MO000019984
p300
CBP_enti_MO000017462
CBP
IRF3{p}: IRF3: CBP: p300_enti_e25
IRF3{p}: IRF3: CBP: p300
IRF3{p}: IRF3: CBP: p300 {nucleus}_enti_e26
IRF3{p}: IRF3: CBP: p300 {nucleus}
IFN-beta_enti_G010228
IFN-beta
TLR4_enti_MO000019394
TLR4
LPS_enti_MO000016882
LPS
IKK-i {activated}_enti_MO000016608
IKK-i {activated}
TBK1 {activated}_enti_MO000019331
TBK1 {activated}
PI3K_enti_MO000000030
PI3K
imidazoquinolines_enti_e27
imidazoquinolines
imidazoquinolines: TLR7_enti_e28
imidazoquinolines: TLR7
IFN-alpha_enti_e29
IFN-alpha
MyD88_enti_MO000016573
MyD88
ssRNA: TLR7: MyD88_enti_e30
ssRNA: TLR7: MyD88
dsDNA: TLR9: MyD88_enti_e31
dsDNA: TLR9: MyD88
IRF-7_enti_MO000007702
IRF-7
IRF-7: MyD88_enti_e32
IRF-7: MyD88
IRAK1_enti_e33
IRAK1
IRF-7 [p}_enti_e35
IRF-7 [p}
LPS: TLR4_enti_e34
LPS: TLR4
LPS: TLR4: MyD88: Mal_enti_e36
LPS: TLR4: MyD88: Mal
MAL_enti_MO000068831
MAL
TIRAP_enti_MO000022528
TIRAP
LPS: TLR4: TRIF: TIRAP_enti_e37
LPS: TLR4: TRIF: TIRAP
IRAK-4_enti_MO000039077
IRAK-4
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4_enti_e38
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4
TRAF6_enti_MO000000212
TRAF6
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A_enti_e39
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A
Ubc13_enti_MO000022136
Ubc13
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6_enti_e41
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}_enti_e42
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}
TAK1_enti_MO000016574
TAK1
TAB2_enti_MO000022125
TAB2
TAB3_enti_MO000041541
TAB3
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1: TAB2: TAB3_enti_e43
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1: TAB2: TAB3
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1{activated}: TAB2: TAB3_enti_e44
LPS: TLR4: MyD88: Mal: IRAK-1: IRAK-4: Ubc13: Uev1A: TRAF6 {ub (n)}: TAK1{activated}: TAB2: TAB3
IKK-alpha:IKK-beta:IKK-gamma_enti_MO000016661
IKK-alpha:IKK-beta:IKK-gamma
IKK-alpha:IKK-beta:IKK-gamma {activated}_enti_e45
IKK-alpha:IKK-beta:IKK-gamma {activated}
MEKKs_enti_MO000000060
MEKKs
MEKKs {activated}_enti_e46
MEKKs {activated}
IRF-7: TRAF6_enti_e47
IRF-7: TRAF6
Uev1_enti_e48
Uev1
ssRNA: TLR7: MyD88: IRAK-1:IRAK-4_enti_e40
ssRNA: TLR7: MyD88: IRAK-1:IRAK-4
dsDNA: TLR9: MyD88: IRAK-1: IRAK-4_enti_e49
dsDNA: TLR9: MyD88: IRAK-1: IRAK-4
ssRNA: TLR7: MyD88: IRAK-1:IRAK-4: TRAF6_enti_e63
ssRNA: TLR7: MyD88: IRAK-1:IRAK-4: TRAF6
dsDNA: TLR9: MyD88: IRAK-1: IRAK-4:TRAF6_enti_e64
dsDNA: TLR9: MyD88: IRAK-1: IRAK-4:TRAF6
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB {activated}_enti_e65
NF-kappaB {activated}
IRF-5_enti_MO000007700
IRF-5
IRF-5 {activated}_enti_e66
IRF-5 {activated}
IRF-5 {nucleus}_enti_e67
IRF-5 {nucleus}
RIP1_enti_MO000000065
RIP1
dsRNA:TLR3:TRIF: RIP1_enti_e68
dsRNA:TLR3:TRIF: RIP1
dsRNA:TLR3:TRIF: RIP1{ub}_enti_e69
dsRNA:TLR3:TRIF: RIP1{ub}
IKK-i_enti_e70
IKK-i
TBK1_enti_e71
TBK1
IRF-7_enti_G010713
IRF-7
IFNbeta_enti_MO000016660
IFNbeta
RANTES_enti_G010522
RANTES
IP-10_enti_e72
IP-10
TNF-alpha_enti_G010329
TNF-alpha
IL-6_enti_G010262
IL-6
dsRNA: PKR {p}_enti_e73
dsRNA: PKR {p}
dsRNA: RIG-I {activated}_enti_e74
dsRNA: RIG-I {activated}
V protein_enti_e75
V protein
V protein: Mda-5_enti_e76
V protein: Mda-5
dsRNA: RIG-I {activated}: IKK-i: TBK1_enti_e77
dsRNA: RIG-I {activated}: IKK-i: TBK1