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PMID:16332394,12649139
The major collagen receptor on platelets is GpVI, a transmembrane immunoglobulin-superfamily receptor
PMID:16332394,9295288,9280292
GpVI is structurally related to the IgA Fcalpha-receptors and it is associated with the ITAM-bearing FcR gamma-chain
PMID: 16332394,10506151,9280292,9295288
GpVI is structurally related to the IgA Fcalpha-receptors and it is associated with the ITAM-bearing FcR gamma-chain
indirect
PMID: 16332394,11110698
Ligation of GpVI leads to the phosphorylation of FcR gamma-chain by the Src-family kinases Fyn and Lyn, which are also required for activation of these cells
PMID: 16332394,11110698
Ligation of GpVI leads to the phosphorylation of FcR gamma-chain by the Src-family kinases Fyn and Lyn, which are also required for activation of these cells
indirect
PMID: 16332394,9171347
The FcR γ-chain is in turn required for the activation of the Syk tyrosine kinase
PMID: 16332394
After the initial, collagen-induced activation step, platelets are further activated through other cell surface receptors including the AlphaIIbbeta3 integrins
indirect
PMID: 16332394,7961845
Platelet activation by fibrinogen leads to the tyrosine phosphorylation of Syk
PMID: 16332394,11719224,12171941
biochemical studies suggest a direct interaction between alphaIIbβ3 and Syk
PMID: 16332394,15085135
Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively
PMID: 16332394,15085135
Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively
PMID: 16332394,15085135
Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively
PMID: 16332394,15085135
Osteoclasts express at least two ITAM-bearing molecules, DAP12 and the FcR gamma-chain; these adapters likely associate with the TREM2 and OSCAR receptors on the surface of osteoclasts, respectively
indirect
PMID: 16332394,15073337
Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts
indirect
PMID: 16332394,15073337
Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts
indirect
PMID: 16332394,15073337
Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts
indirect
PMID: 16332394,15073337
Syk activation requires DAP12 and the FcR gamma-chain in osteoclasts
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-beta
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,9655483,12426564,12426565,15294961,9490415,9625766,10049942,9574512,9647200,10411005,11073118,10528196,14970179
The DAP12-associated NK-cell receptors include CD94/NKG2C,an alternatively spliced short form of murine (but not human) NKG2D (NKG2D-S) and activating KIR (KIR-S) molecules , NKp44 and , Ly49D and , Ly49H and , Ly49L , Ly49P and PIRL-β
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10601355
Based on sequence homology, the CD94/NKG2C-related CD94/NKG2E complex (and its alternatively spliced NKG2H form) is also likely to associate with DAP12
PMID: 16332394,10601355
Based on sequence homology, the CD94/NKG2C-related CD94/NKG2E complex (and its alternatively spliced NKG2H form) is also likely to associate with DAP12
PMID: 16332394,11950999
The murine cytomegalovirus (MCMV) encoded m157 protein is a ligand of the murine Ly49H protein
PMID: 16332394,11536166
NKp44 recognizes viral hemagglutinin on influenza or Sendai virus-infected cells, leading to the elimination of these cells
PMID: 16332394,11557981,11248803
The murine NKG2D molecules recognize Rae-1 and H-60, MHC-I related “suicude” molecules expressed on tumor cells that can target these cells to killing by NKG2D-expressing immune cells
PMID: 16332394,11557981,11248803
The murine NKG2D molecules recognize Rae-1 and H-60, MHC-I related “suicude” molecules expressed on tumor cells that can target these cells to killing by NKG2D-expressing immune cells
PMID: 16332394,11973127
It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2
PMID: 16332394,11973127
It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2
PMID: 16332394,11973127
It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2
PMID: 16332394,11973127
It should also be noted that human NKG2D recognizes yet other tumor-induced surface molecules like MICA/MICB and ULBP1/2
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394,9396764,10562324,10359120
Besides the classical immunoreceptor FcγRIII, NK-cell receptors associated with these adapters include the FcR gamma-chain-associated NKR-P1C moleculethe CD3 zeta-chain-associated NKp30 , as well as NKp46, which associates with both the FcR gamma-chain and the CD3 zeta-chain
PMID: 16332394
It should be noted that the FcR gamma-chain and CD3 zeta-chain can form heterodimers in NK-cells and thus association of the above receptors (in particular the NKp46 molecule) with both sidechains in such heterodimers cannot be excluded.
PMID: 16332394,10799849,11323674
These include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,16081415,14970179
These include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions and SIRPβ1, a counterreceptor of CD47, which is involved in transendothelial migration of neutrophils ; as well as PIRLβ, a novel receptor for CD99-related ligands
PMID: 16332394,16081415,14970179
hese include receptors associated with the ITAM-bearing DAP12 adapter, like TREM-1, which participates in acute inflammatory reactions and SIRPβ1, a counterreceptor of CD47, which is involved in transendothelial migration of neutrophils ; as well as PIRLβ, a novel receptor for CD99-related ligands
PMID: 16332394,8962144,9218786
These include CEACAM3 (also known as CD66b or CGM1), a receptor of Neisseria gonorrheae Opa proteins
PMID: 16332394,12864848
In heterologous expression systems, Opa-expressing gonococci were able to induce the phosphorylation of the CEACAM3 ITAM
PMID: 16332394,9029132
The Syk tyrosine kinase is also present in neutrophils and it becomes activated by ligation of β2 integrins on the surface of neutrophils
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,10799849,11754004,10449773,12960329,10604985,15123631,14970179,15557162,12426565,12874256,9892613,10477705,9886363
These include the DAP12-associated TREM-1/3 and MDL-1,CD200RL,SIRPβ1, PILRβ,IREM-2,NKG2D-S and MAIR-II , as well as the FcR γ-chain-associated PIR-A and and ILT-1/LILRA molecules
PMID: 16332394,12163569,11544516,12719478
One such receptor is Dectin-1, a C-type lectin on the surface of macrophages, which is the predominant receptor for the fungal antigen β-glucan
PMID: 16332394,14630197
The major receptor on mast cells is Fcvar epsilonRI, a conventional Fc-receptor for IgE, which associates with the FcR gamma-chain and transmits an ITAM- and Syk-dependent activation signal
PMID: 16332394,14630197
The major receptor on mast cells is Fcvar epsilonRI, a conventional Fc-receptor for IgE, which associates with the FcR gamma-chain and transmits an ITAM- and Syk-dependent activation signal
PMID: 16332394,15471863,12893283
Basophils and mast cells also express the DAP12-associated CD200R3 and the LMIR2 receptor, which is able to associate with either DAP12 or the FcR gamma-chain
indirect
PMID: 16332394,12387735
The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.
PMID: 16332394,12387735
The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.
indirect
PMID: 16332394,11850456,10828067,15173175
Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase
indirect
PMID: 16332394,11850456,10828067,15173175
Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase
PMID: 16332394,11850456,10828067,15173175
Tamalin, a metabotropic glutamate receptor-associated neuronal scaffolding protein also known as GRASP and , contains an ITAM sequence, which becomes phosphorylated by the Src-family kinases Src and Fyn, leading to the recruitment of the Syk tyrosine kinase
indirect
PMID: 16332394,12387735
The PSGL-1 adhesion molecule has been shown to activate Syk and downstream gene transcription through a mechanism involving ITAM-dependent interaction of moesin with the Syk SH2 domains , indicating an ITAM-based mechanism in general cytoskeletal regulation.
PMID: 16332394,10899310,10993906,9133424
Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins
PMID: 16332394,10899310,10993906,9133424
Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins
PMID: 16332394,10899310,10993906,9133424
Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins
PMID: 16332394,10899310,10993906,9133424
Both STAM1 and STAM2 associate with and become phosphorylated by Jak kinases, mediated by the ITAM region of the STAM proteins