1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16357866.csml convertedTime:2009.07.01.10:53

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Lipopolysaccharide signaling in endothelial cells.
Authors Dauphinee SM, Karsan A.
Affiliation Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver,British Columbia, Canada.
Abstract Sepsis is the systemic immune response to severe bacterial infection. The innateimmune recognition of bacterial and viral products is mediated by a family oftransmembrane receptors known as Toll-like receptors (TLRs). In endothelialcells, exposure to lipopolysaccharide (LPS), a major cell wall constituent ofGram-negative bacteria, results in endothelial activation through a receptorcomplex consisting of TLR4, CD14 and MD2. Recruitment of the adaptor proteinmyeloid differentiation factor (MyD88) initiates an MyD88-dependent pathway thatculminates in the early activation of nuclear factor-kappaB (NF-kappaB) and themitogen-activated protein kinases. In parallel, a MyD88-independent pathwayresults in a late-phase activation of NF-kappaB. The outcome is the productionof various proinflammatory mediators and ultimately cellular injury, leading tothe various vascular sequelae of sepsis. This review will focus on the signalingpathways initiated by LPS binding to the TLR4 receptor in endothelial cells andthe coordinated regulation of this pathway.
PMID 16357866
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010514:NOS MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000041:Cot MO000000048:AKT MO000000065:RIP1 MO000000079:ASK1 MO000000210:IKK-alpha: IKK-beta: IKK-gamma {phosphorylated} MO000000212:TRAF6 MO000000215:IkappaB: NF-kappaB MO000000289:TNF-alpha MO000007694:IRF-3 MO000008301:Syk MO000009093:MEKK3 MO000016569:IRAK-M MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016591:A20 MO000016608:IKK-i MO000016882:LPS MO000016899:FADD MO000016900:Caspase-8 MO000017113:PtdIns(3,4)P2 MO000017264:IL-8 MO000017462:CBP MO000017583:PtdIns MO000019331:TBK1 MO000019394:TLR4 MO000019406:Tollip MO000019420:LBP MO000019984:p300 MO000021003:ROS MO000021199:NOS MO000021928:LPS:LBP MO000022125:TAB2 MO000022136:Ubc13 MO000022200:MD-1 MO000022528:TIRAP MO000030898:JIP3 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041541:TAB3 MO000044786:ST2 MO000061452:TIFA MO000061958:TRIAD3 MO000066718:SIGIRR e1: e10: e11:TLR4: MD-2 e12:LPS: TLR4: MD-2 e13:CXCR4: Hsp70: Hsp90: GDF5 e14:LPS: CXCR4: Hsp70: Hsp90: GDF5 e15:IRAK1 e16:SHIP1 e17:LPS: TLR4: MD-2: MyD88: TIRAP e18:LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1: IRAK4:TRAF6 e19:LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1{p}: IRAK4:TRAF6 e2: e20:LPS: TLR4: MD-2: TRAM: TRIF e21:LPS: TLR4: MD-2: TRAM: TRIF: TBK1: IKK-i e22:IRAK1{p}: TRAF6 e23:IRAK1{p}: TRAF6: TAK1: TAB1: TAB2: TAB3 e24:Uev1A e25:IRAK1{p}: TRAF6: TAK1{ activated}: TAB1: TAB1: TAB3: Ubc13: Uev1a e26:e26 e27:IRAK1 { degraded } e28:TRAF6 {ubiquitinated} e29:IkappaB {p}: NF-kappaB e3: e30:IkappaB {degraded} e31:IKK-alpha: IKK-beta: IKK-gamma e32:NF-kappaB e33:NFkappaB {nucleus} e34:p38 {activated} e35:ERK {activated} e36:JNK {activated} e37:MEKK3: TRAF6 e38:NF-kappaB {activated} e39:ASK1: TRAF6 e4: e40:IL-12 e41:PI3K {activated} e42:LPS: TLR4: MD-2: TRAM: TRIF: RIP1: TRAF6 e43:IRF-3 {activated} e44:2 IRF-3 {p}{nucleus} e45:NAP1 e46:LPS: TLR4: MD-2: TRAM: TRIF: TBK1: IKK-i: NAP1 e47:Dok1 e48:Dok2 e49:NO e5:sCD14 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS: sCD14 e60: e61: e62: e63:MyD88: TIRAP: ST2 e64:SOCS1 e65:RP105 e66:TLR4: MD-2: RP105: MD2 e67:TLR4 {ubiquitinated} e68:TLR4 {degraded} e69:MyD88s e7:Nos2 e70:IRAK1{p}: TRAF6: TAK1{p}: TAB1: TAB2: TAB3 e71:LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1{p}: IRAK4: TRAF6 e72:IRAK1{p}: TRAF6: TAK1{p}: TAB1: TAB2: TAB3 e73:IRAK1{p}: TRAF6: TAK1{ activated}: TAB1: TAB2: TAB3: Ubc13: Uev1a e74:IRAK1{p}: nTRAF6: TAK1{ activated}: TAB1: TAB2: TAB3: Ubc13: Uev1a e75:PtdIns(3,4,5)P3 e76:IkappaB {p} {ub}: NF-kappaB e77:MyD88: PI3K e78:TLR4: PI3K e79:IRF-3 {p} e8:Tollip: IRAK1 e80:2 IRF-3 {p} e81:JIP3: TLR4 e82:2 IRF-3 {p}{nucleus}: p300: OBP e83:IFNbeta e84:IP-10(m) e85:GARG16 e86:IL-8 e87:SIGIRR: TLR4 e88:TRIAD3: TLR4 e89:IRAKM: TRAF6 e9:AKT {activated} e90:MyD88: IRAK-M e91:MyD88: FADD e92:MyD88: FADD: Caspase-8 e93:A1 e94:p44 e95:p42 e96:p44 {activated} e97:p42 {activated}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p9
Model Detail
920.0, 1349.0
42.5, 42.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34 p39

p40

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
994.0, 1259.0
37.5, 37.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
825.0, 1330.0
39.0, 39.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p28

p43

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
603.0, 1328.0
35.0, 35.0

NOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

p46

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
885.0, 858.0
39.5, 39.5

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p68

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
562.0, 627.0
37.0, 37.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p22 p27

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
873.0, 906.0
40.0, 40.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p66

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
602.0, 847.0
37.0, 37.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1070.0, 895.0
38.0, 38.0

Cot

--

MO000000041

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000041

--

Go back
421.0, 830.0
40.0, 40.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p61

true true true true

csml-variable:Double

m9

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
413.0, 526.0
31.0, 31.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
518.0, 463.0
46.0, 46.0

ASK1

--

MO000000079

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000079

--

Go back
1121.0, 1046.0
64.0, 64.0

IKK-alpha: IKK-beta: IKK-gamma {phosphorylated}

--

MO000000210

cso30:c:Complex

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1053.0, 418.0
40.0, 40.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p7 p8 p23 p26 p32 p76

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1223.0, 1056.0
44.5, 44.5

IkappaB: NF-kappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
1175.0, 1540.0
44.0, 44.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
426.0, 1307.0
37.0, 37.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p42

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
652.0, 861.0
42.0, 42.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
792.0, 565.0
41.0, 41.0

MEKK3

--

MO000009093

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1116

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009093

--

Go back
1046.0, 303.0
38.0, 38.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p9 p76 p77

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
687.0, 252.0
43.5, 43.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p50 p62 p71 p77

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1217.0, 398.0
56.0, 56.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1228.0, 461.0
33.0, 33.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
650.0, 971.0
38.0, 38.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p24 p25 p33

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
423.0, 784.0
36.0, 36.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
354.0, 47.0
38.0, 38.0

LPS

--

MO000016882

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1 p4

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1221.0, 1282.0
34.0, 34.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p71

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
1228.0, 1413.0
42.0, 42.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
475.0, 948.0
36.0, 36.0

PtdIns(3,4)P2

--

MO000017113

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p61

true true true true

csml-variable:Double

m157532

10

false

infinite

0

unit false false false
TRANSPATHMO000017113

--

Go back
455.0, 1208.0
36.0, 36.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
953.0, 1446.0
40.0, 40.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
423.0, 1020.0
36.0, 36.0

PtdIns

--

MO000017583

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m347277

10

false

infinite

0

unit false false false
TRANSPATHMO000017583

--

Go back
417.0, 726.0
40.0, 40.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
732.0, 1585.0
42.0, 42.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p67 p74 p75

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
672.0, 377.0
34.0, 34.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
425.0, 106.0
40.0, 40.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_Extracellular

--

p2

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
899.0, 1456.0
36.0, 36.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
506.0, 514.0
60.0, 60.0

ROS

--

MO000021003

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m5401

10

false

infinite

0

unit false false false
TRANSPATHMO000021003

--

Go back
503.0, 1264.0
36.0, 36.0

NOS

--

MO000021199

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

--

true true true true

csml-variable:Double

m5574

10

false

infinite

0

unit false false false
TRANSPATHMO000021199

--

Go back
502.0, 43.0
46.0, 46.0

LPS:LBP

--

MO000021928

cso30:c:Complex

cso30:i:CC_Extracellular

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
1226.0, 515.0
29.0, 29.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1231.0, 744.0
36.0, 36.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
447.0, 336.0
35.0, 35.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
682.0, 303.0
38.0, 38.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p50

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1004.0, 1517.0
42.0, 42.0

JIP3

--

MO000030898

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m10459

10

false

infinite

0

unit false false false
InterProIPR000508
TRANSPATHMO000030898

--

Go back
1044.0, 361.0
34.0, 34.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p7

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
418.0, 443.0
37.5, 37.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
418.0, 383.0
37.0, 37.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1224.0, 573.0
34.0, 34.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
514.0, 351.0
45.0, 45.0

ST2

--

MO000044786

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m22456

10

false

infinite

0

unit false false false
TRANSPATHMO000044786

--

Go back
1104.0, 969.0
42.0, 42.0

TIFA

--

MO000061452

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m36350

10

false

infinite

0

unit false false false
TRANSPATHMO000061452

--

Go back
430.0, 1539.0
38.0, 38.0

TRIAD3

--

MO000061958

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p75

true true true true

csml-variable:Double

m36851

10

false

infinite

0

unit false false false
TRANSPATHMO000061958

--

Go back
872.0, 1549.0
42.0, 42.0

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
342.906202743638, 188.3909640254102
1016.2111513520356, 1470.6860604269864

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
383.3092040285079, 265.7148061481238
937.6059827049462, 1314.6104178617038

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
480.375, 188.5
46.29393673110722, 71.2214411247803

TLR4: MD-2

--

e11

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3 p51

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
771.375, 180.5
42.64793904845429, 82.5443981582986

LPS: TLR4: MD-2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p5 p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
346.375, 254.5
45.60852372583479, 70.16695957820738

CXCR4: Hsp70: Hsp90: GDF5

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
403.375, 176.5
42.43044288533216, 82.1234378425784

LPS: CXCR4: Hsp70: Hsp90: GDF5

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
871.125, 391.5
27.75, 45.0

IRAK1

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12

p7 p13 p47

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
585.0, 738.0
32.0, 32.0

SHIP1

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p21 p22 p27 p49 p59 p61 p66 p68

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR000300
TRANSPATHMO000017112

--

Go back
968.375, 177.5
49.974841043630754, 96.72549879412415

LPS: TLR4: MD-2: MyD88: TIRAP

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5 p9

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1056.375, 166.5
57.32893005919754, 110.95921946941465

LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1: IRAK4:TRAF6

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p54

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1197.375, 157.5
62.44688664766499, 120.86494189870642

LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1{p}: IRAK4:TRAF6

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
342.906202743638, 188.3909640254102
1016.2111513520356, 1470.6860604269864

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
339.375, 452.5
42.899418987064244, 83.03113352335012

LPS: TLR4: MD-2: TRAM: TRIF

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p32 p35

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
349.375, 1231.5
48.20768471826353, 93.30519622889717

LPS: TLR4: MD-2: TRAM: TRIF: TBK1: IKK-i

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36 p41

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1294.625, 312.5
61.42555407432095, 75.21496417263789

IRAK1{p}: TRAF6

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10 p31

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1290.5, 564.0
68.14764205965672, 83.44609231794699

IRAK1{p}: TRAF6: TAK1: TAB1: TAB2: TAB3

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p56

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1232.0, 793.5
41.344334876232644, 25.495673173676796

Uev1A

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
961.5, 662.0
78.20729878353609, 95.76403932677887

IRAK1{p}: TRAF6: TAK1{ activated}: TAB1: TAB1: TAB3: Ubc13: Uev1a

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p12 p15 p19 p20 p21

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
873.0, 554.0
40.0, 40.0

e26

--

e26

cso30:c:ObjectUnknown

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
622.0, 428.0
46.14589316484779, 44.607696726019526

IRAK1 { degraded }

--

e27

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
974.0, 492.5
46.080000000000005, 34.559999999999995

TRAF6 {ubiquitinated}

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12

p14

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1211.0, 1118.0
60.0, 48.0

IkappaB {p}: NF-kappaB

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
363.2304257706786, 208.64834777784804
975.5627052979542, 1430.171292922109

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1153.0, 1299.0
40.23549684089603, 38.89431361286617

IkappaB {degraded}

--

e30

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1205.0, 970.0
64.0, 64.0

IKK-alpha: IKK-beta: IKK-gamma

--

e31

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
662.0, 1079.0
46.0, 46.0

NF-kappaB

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p25 p33

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
Affymetrix1377_at
EnsemblENSG00000109320
HGNCNFKB1
OMIM164011
ProteomeHumanPSD/NFKB1
RefSeqNM_003998
TRANSFACT01925
TRANSPATHMO000019359
UnigeneHs.654408
UniProtP19838

--

Go back
812.0, 1164.5
57.693700945864364, 35.57778224994969

NFkappaB {nucleus}

--

e33

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p18

p28 p29 p30 p34 p72

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
686.0, 699.0
37.0, 37.0

p38 {activated}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19 p22 p27

--

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
885.0, 742.0
39.5, 39.5

ERK {activated}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p68

--

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
876.0, 952.0
40.0, 40.0

JNK {activated}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p66

--

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
708.5, 540.0
49.0, 60.0

MEKK3: TRAF6

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p22 p24

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
894.0, 1083.0
46.0, 46.0

NF-kappaB {activated}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p25 p33 p59

p18

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
Affymetrix1377_at
EnsemblENSG00000109320
HGNCNFKB1
OMIM164011
ProteomeHumanPSD/NFKB1
RefSeqNM_003998
TRANSFACT01925
TRANSPATHMO000019359
UnigeneHs.654408
UniProtP19838

--

Go back
472.5, 596.0
49.0, 60.0

ASK1: TRAF6

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
400.83023837070414, 244.09876934461397
900.363080097904, 1359.2704497885773

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
715.5, 1200.0
51.22837370242215, 27.32179930795848

IL-12

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
547.0, 1160.0
35.0, 35.0

PI3K {activated}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p21 p28 p30 p45 p46 p48 p60 p62 p63 p79 p80

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
335.375, 591.5
52.15659942994957, 100.94825696119271

LPS: TLR4: MD-2: TRAM: TRIF: RIP1: TRAF6

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
498.0, 1379.0
37.0, 37.0

IRF-3 {activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p42

p64

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
735.5, 1465.125
66.44, 49.82999999999999

2 IRF-3 {p}{nucleus}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

p38 p69 p70

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
427.0, 1472.0
35.0, 35.0

NAP1

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
Affymetrix207738_s_at
EnsemblENSG00000061676
HGNCNCKAP1
OMIM604891
ProteomeHumanPSD/NCKAP1
RefSeqNM_013436
TRANSPATHMO000079843
UnigeneHs.603732
UniProtQ9Y2A7

--

Go back
347.375, 1347.5
51.83715194036395, 100.32997149747864

LPS: TLR4: MD-2: TRAM: TRIF: TBK1: IKK-i: NAP1

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p42

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1091.0, 1344.0
36.0, 36.0

Dok1

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p28 p43 p44 p68

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
Affymetrix1552849_at
EnsemblENSG00000115325
HGNCDOK1
InterProIPR002404
OMIM602919
ProteomeHumanPSD/DOK1
RefSeqNM_001381
TRANSPATHMO000087528
UnigeneHs.103854
UniProtQ99704

--

Go back
1140.5, 1403.125
40.03999999999999, 30.02999999999999

Dok2

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20 p28 p43 p44 p68

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1233.5, 1554.5
39.70588235294118, 23.82352941176471

NO

--

e49

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
590.5, 49.125
45.0, 33.75

sCD14

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

p3

p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
578.8797604391643, 1108.1128440475964
489.65406529001297, 442.602072753605

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
631.7660468205809, 1118.6018697296518
286.3154124787042, 428.9695653792638

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
585.2625881058871, 1114.0202639098106
476.8884099565679, 430.787233029176

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
586.1744206297046, 1114.9290977347666
475.06474490893254, 428.9695653792638

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
578.8797604391643, 1108.1128440475964
489.65406529001297, 442.602072753605

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
578.8797604391643, 1108.1128440475964
489.65406529001297, 442.602072753605

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
586.1744206297046, 1114.9290977347666
475.06474490893254, 428.9695653792638

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
936.3181097756355, 1289.87960903881
30.590895593063486, 27.601738760071882

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
856.0768476796932, 1417.1163445326595
86.62408976266524, 78.15970894622183

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
578.8797604391643, 1108.1128440475964
489.65406529001297, 442.602072753605

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
587.5, 107.125
50.279999999999994, 37.709999999999994

LPS: sCD14

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
694.2884685342324, 1304.8015479282635
15.50662477666179, 7.441599100453018

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
693.7706584401731, 1282.6089384391612
53.0755346410769, 95.22177792417054

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
716.0364924847229, 1344.541802129679
8.284961504948583, 8.257715158735653

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
601.5, 342.0
46.180216553496045, 64.43751146999449

MyD88: TIRAP: ST2

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p5

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
914.0, 1012.5
36.152143288388004, 22.293821694505944

SOCS1

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24 p25 p33

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
430.0, 283.0
38.0, 38.0

RP105

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000046669

--

Go back
600.5, 170.0
41.05919754439817, 79.46941460206095

TLR4: MD-2: RP105: MD2

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p51

p3

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
657.5, 1580.0
39.0, 60.0

TLR4 {ubiquitinated}

--

e67

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

p53

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
509.0, 1515.0
31.826536473291213, 30.76565192418151

TLR4 {degraded}

--

e68

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p53

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
940.8000000000001, 331.5
48.16000000000001, 36.120000000000005

MyD88s

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
684.0, 1237.0
34.0, 34.0

Nos2

--

e7

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p48

--

true true true true

csml-variable:Double

m7

10

false

infinite

0

unit false false false
Affymetrix104420_at
EnsemblENSMUSG00000020826
MGDNos2
ProteomeHumanPSD/Nos2
RefSeqNM_010927
TRANSFACG001073
UnigeneMm.2893

--

Go back
1289.5, 658.0
71.40559906682219, 87.43542742876187

IRAK1{p}: TRAF6: TAK1{p}: TAB1: TAB2: TAB3

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p57

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1301.5, 146.0
70.73383030037272, 136.90418767814077

LPS: TLR4: MD-2: MyD88: TIRAP: IRAK1{p}: IRAK4: TRAF6

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1135.5, 644.0
66.44521930629473, 92.71425949715544

IRAK1{p}: TRAF6: TAK1{p}: TAB1: TAB2: TAB3

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p11

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1197.5, 836.0
71.5588181317673, 99.84951367223344

IRAK1{p}: TRAF6: TAK1{ activated}: TAB1: TAB2: TAB3: Ubc13: Uev1a

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p58

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1058.5, 775.0
61.560469810974496, 85.89832996880162

IRAK1{p}: nTRAF6: TAK1{ activated}: TAB1: TAB2: TAB3: Ubc13: Uev1a

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p55

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
427.0, 964.0
36.0, 36.0

PtdIns(3,4,5)P3

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p49

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000017113

--

Go back
1214.0, 1196.0
54.0, 60.0

IkappaB {p} {ub}: NF-kappaB

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p59

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
412.5, 1072.0
49.0, 60.0

MyD88: PI3K

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
793.5, 1537.0
38.449243586932695, 74.4178908134181

TLR4: PI3K

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p63

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
511.5, 1427.125
51.08, 38.31

IRF-3 {p}

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
812.5, 341.0
33.74720879853357, 41.32311281453091

Tollip: IRAK1

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
574.5, 1485.125
66.44, 49.82999999999999

2 IRF-3 {p}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p65

p37

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1063.375, 1569.5
42.342085069063806, 81.95242271431704

JIP3: TLR4

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p66

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
845.875, 1380.5
53.74605432189391, 74.99449440264269

2 IRF-3 {p}{nucleus}: p300: OBP

--

e82

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p38

p39

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1113.0, 1546.0
40.0, 40.0

IFNbeta

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
Affymetrix1214_s_at
EnsemblENSG00000171855
HGNCIFNB1
InterProIPR000471
OMIM147640
ProteomeHumanPSD/IFNB1
RefSeqNM_002176
TRANSPATHMO000032635
UnigeneHs.93177
UniProtP01574

--

Go back
666.0, 1431.0
38.0, 38.0

IP-10(m)

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p69

--

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
768.0, 1349.0
34.0, 34.0

GARG16

--

e85

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p70

--

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
Affymetrix100981_at
EnsemblENSMUSG00000034459
MGDIfit1
ProteomeHumanPSD/Ifit1
RefSeqNM_008331
TRANSFACG043145
UnigeneMm.439751

--

Go back
724.0, 1289.0
49.515570934256054, 26.408304498269896

IL-8

--

e86

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p72

p73

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
949.5, 1557.0
46.40824380618285, 89.82240736680552

SIGIRR: TLR4

--

e87

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
531.5, 1577.0
42.833150624862974, 82.90287217715414

TRIAD3: TLR4

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

p52

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1233.5, 333.0
44.46825529078486, 54.45092484585903

IRAKM: TRAF6

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p76

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
425.0, 890.0
40.0, 40.0

AKT {activated}

--

e9

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p61

--

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
900.5, 341.0
41.47158806865522, 50.78153641059822

MyD88: IRAK-M

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1222.5, 1338.0
45.9380103316114, 56.25062489585069

MyD88: FADD

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

p78

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1231.5, 1468.0
42.33712607817948, 59.07505964397137

MyD88: FADD: Caspase-8

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
638.0, 1020.5
37.28, 27.96

A1

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24 p25 p33

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
503.0, 994.5
36.44194002817469, 22.472529684041067

p44

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p79

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
567.0, 999.5
35.379351982290196, 21.817267055745624

p42

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p80

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
535.0, 934.5
36.79211108875025, 22.688468504729318

p44 {activated}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p79

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
562.0, 890.5
37.91507345542363, 23.380961964177907

p42 {activated}

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
430.0, 51.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 16357866, 2402637 LBP is an acute-phase protein, the role of which is to bring LPS to the cell surface by binding to LPS and forming a ternary complex with the LPS receptor molecule, CD14.

Go back
1382.0, 487.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016574 MO000022125 MO000016588 MO000041541

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c42 : 1

m22*m1573*m6433*m1583*m19389*0.1

nodelay

--

true

0

false

PMID: 16357866, 12242293 The complex of IRAK1 and TRAF6 dissociates from the receptor to form a complex at the membrane with transforming growth factor-b (TGFb)-activated kinase 1 (TAK1) and the adaptor molecules, TAK1-binding protein 1 and 2 (TAB1 and TAB2). a third adaptor molecule has been identified, TAB3, which also interacts with TAK1. PMID: 16357866, 10882101, 15836773 TAB2 links TAK1 to TRAF6 and facilitates the ubiquitination of TRAF6.

Go back
1154.0, 799.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022136 e24 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c35 : 1
stoichiometry:c197 : 1

m6443*m24*m79*0.1

nodelay

--

true

0

false

PMID: 16357866 it forms a complex with the ubiquitin conjugating enzyme Ubc13 and the Ubc-like protei.

Go back
930.0, 559.0
30.0, 30.0

p12

p12

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e25

e15 e28 e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c45 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 16357866 When TAK1 is activated, IRAK1 is released from the complex.

Go back
738.0, 435.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e15

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 16357866, 9261174 When TAK1 is activated, IRAK1 is released from the complex and eventually degraded by the ubiquitin?proteasome system.

Go back
1058.0, 499.0
30.0, 30.0

p14

p14

cso30:i:ME_Deubiquitination

cso30:i:CC_Cytosol

--

e28 MO000016591

MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c239 : 1
stoichiometry:c112 : 1

m28*m1585*0.1

nodelay

--

true

0

false

PMID: 16357866, 14550571 TRAF6 is recycled through the process of deubiquitination. PMID: 16357866 A20 is dependent on its ability to act as a TRAF6 deubiquitinase.

Go back
1062.0, 1043.0
30.0, 30.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e25 e31

MO000000210

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m25*m31*0.1

nodelay

--

true

0

false

PMID: 16357866, 11460167 TAK1-mediated phosphorylation of the IkB kinase (IKK) complex, composed of two catalytic subunits, IKKa and IKKb, and a regulatory subunit, IKK-gamma, also known as NF-kappaB essential modulator (NEMO).

Go back
1138.0, 1143.0
30.0, 30.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000215 MO000000210

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m186*m181*0.1

nodelay

--

true

0

false

PMID: 16357866 Activation of the IKKs leads to downstream phosphorylation of members of the inhibitor of NF-kappaB (IkB) family.

Go back
1154.0, 1199.0
30.0, 30.0

p17

p17

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e29

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 16357866, 7628694 Activation of the IKKs leads to downstream phosphorylation of members of the inhibitor of NF-kB (IkB) family, resulting in ubiquitin-directed proteasome- mediated degradation of the IkB members, thus permitting the release and nuclear translocation of the transcription factor, NF-kB.

Go back
830.0, 1107.0
30.0, 30.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_NuclearInnerMembrane

--

e38

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16357866, 7628694 Activation of the IKKs leads to downstream phosphorylation of members of the inhibitor of NF-kappaB (IkappaB) family, resulting in ubiquitin-directed proteasome- mediated degradation of the IkappaB members, thus permitting the release and nuclear translocation of the transcription factor, NF-kappaB.

Go back
854.0, 679.0
30.0, 30.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e25 e16

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c65 : 1
stoichiometry:c162 : 1
stoichiometry:c64 : 1

m34*m25*0.1

nodelay

--

true

0

false

PMID: 16357866, 11460167 activation of TAK1 also leads to activation of a family of MAPKs consisting of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK). PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
514.0, 111.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000021928

e6 MO000019420

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m5*m6254*0.1

nodelay

--

true

0

false

PMID: 16357866, 2402637 LBP is an acute-phase protein, the role of which is to bring LPS to the cell surface by binding to LPS and forming a ternary complex with the LPS receptor molecule, CD14.

Go back
986.0, 819.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000011 e48 e47 e16

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c166 : 1
stoichiometry:c69 : 1

m25*m36*0.1

nodelay

--

true

0

false

PMID: 16357866, 11460167 activation of TAK1 also leads to activation of a family of MAPKs consisting of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK). PMID: 16357866, 15699069 Overexpression of Dok1 or Dok2 inhibits LPS-induced ERK activation. PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
794.0, 879.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000023 MO000008301 e41 e16

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c70 : 1
stoichiometry:c91 : 1
stoichiometry:c90 : 1
stoichiometry:c167 : 1
stoichiometry:c71 : 1

m25*m38*m1066*m45*0.1

nodelay

--

true

0

false

PMID: 16357866, 11460167 activation of TAK1 also leads to activation of a family of MAPKs consisting of p38, extracellular signal-regulated kinase (ERK) and c-jun NH2-terminal kinase (JNK). PMID: 16357866, 14699155 LPS-induced JNK activation involves the participation of the protein tyrosine kinase, Syk, and PI3K. PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

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630.0, 603.0
30.0, 30.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e37 e16

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c161 : 1
stoichiometry:c73 : 1

m34*m40*0.1

nodelay

--

true

0

false

PMID: 16357866, 12193732 MEKK3 activates both NF-kB and p38 kinase, but not ERK, by binding to TRAF6 in mouse embryonic fibroblasts (MEFs). PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

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798.0, 515.0
31.0, 31.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000009093 MO000000212

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c111 : 1
stoichiometry:c77 : 1

m1116*m183*0.1

nodelay

--

true

0

false

PMID: 16357866, 12193732 MEKK3 activates both NF-kB and p38 kinase, but not ERK, by binding to TRAF6 in mouse embryonic fibroblasts (MEFs).

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750.0, 963.0
30.0, 30.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e37 MO000016591 e64 e93

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c79 : 1
stoichiometry:c24 : 1
stoichiometry:c173 : 1
stoichiometry:c261 : 1
stoichiometry:c78 : 1

m32*m40*0.1

nodelay

--

true

0

false

PMID: 16357866, 12193732 MEKK3 activates both NF-kB and p38 kinase, but not ERK, by binding to TRAF6 in mouse embryonic fibroblasts (MEFs). PMID: 16357866, 12659860 Expression of A20 inhibits TLR4-mediated NF-kappaB activation by regulating MEKK-1 kinase activity. PMID: 16357866, 12433373, 12433365 ectopic expression of SOCS1 in a macrophage cell line inhibits LPSinduced NF-kappaB activation. PMID: 16357866 A1 inhibits endothelial activation by inhibiting NF-kB activity.

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754.0, 1067.0
30.0, 30.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000016591 e64 e93

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c33 : 1
stoichiometry:c175 : 1
stoichiometry:c263 : 1
stoichiometry:c82 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 16357866 Activation of the IKKs leads to downstream phosphorylation of members of the inhibitor of NF-kappaB (IkappaB) family, resulting in ubiquitin-directed proteasome- mediated degradation of the IkappaB members, thus permitting the release and nuclear translocation of the transcription factor, NF-kappaB. PMID: 16357866, 12659860 Expression of A20 inhibits TLR4-mediated NF-kappaB activation by regulating MEKK-1 kinase activity. PMID: 16357866, 12433373, 12433365 ectopic expression of SOCS1 in a macrophage cell line inhibits LPSinduced NF-kappaB activation. PMID: 16357866 A1 inhibits endothelial activation by inhibiting NF-kB activity.

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630.0, 491.0
30.0, 30.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000079 MO000000212 MO000021003

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c109 : 1
stoichiometry:c88 : 1
stoichiometry:c85 : 1

m71*m183*m5401*0.1

nodelay

--

true

0

false

PMID: 16357866, 15864310 LPSinduced intracellular reactive oxygen species (ROS) mediate the formation of a complex between TRAF6 and ASK1 to facilitate activation of p38.

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482.0, 683.0
30.0, 30.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e39 e16

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c89 : 1
stoichiometry:c165 : 1
stoichiometry:c87 : 1

m34*m43*0.1

nodelay

--

true

0

false

PMID: 16357866, 15864310 LPSinduced intracellular reactive oxygen species (ROS) mediate the formation of a complex between TRAF6 and ASK1 to facilitate activation of p38. PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
830.0, 1275.0
30.0, 30.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33 e41 e47 e48

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c132 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c92 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16357866 The MyD88-dependent pathway is largely responsible for controlling the expression of inflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, through activation of NF-kappaB. PMID: 16357866, 12154357, 12052830 Activation of PI3K also reduces MyD88-dependent production of the proinflammatory molecules IL-12 in dendritic cells and TNFa in monocytes. PMID: 16357866, 15699069 Mice that are deficient in Dok1 and Dok2 show an increase in TNFalpha and NO production in peritoneal and bone-marrow derived macrophages, as compared to wild-type cells.

Go back
934.0, 1239.0
30.0, 30.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c93 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16357866 The MyD88-dependent pathway is largely responsible for controlling the expression of inflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, through activation of NF-kappaB.

Go back
754.0, 111.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e11 e66

e12 e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c180 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m6*m11*0.1

nodelay

--

true

0

false

PMID: 16357866, 11274165 Formation of the complex between LPS and CD14 facilitates the transfer of LPS to the LPS receptor complex composed of TLR4 and MD2. PMID: 16357866, 15852007 The complex of RP105 and MD1 interacts with TLR4/MD2, impairing its ability to bind LPS.

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666.0, 1163.0
30.0, 30.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33 e41

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c131 : 1
stoichiometry:c94 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16357866 The MyD88-dependent pathway is largely responsible for controlling the expression of inflammatory cytokines, such as TNF-alpha, IL-6 and IL-12, through activation of NF-kappaB. PMID: 16357866, 12154357, 12052830 Activation of PI3K also reduces MyD88-dependent production of the proinflammatory molecules IL-12 in dendritic cells and TNFa in monocytes.

Go back
606.0, 983.0
30.0, 30.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 MO000000030

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m22*m42*0.1

nodelay

--

true

0

false

PMID: 16357866 activation of TRAF6 also results in the activation of PI3K and Akt.

Go back
414.0, 591.0
30.0, 30.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e20 MO000000212

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c110 : 1
stoichiometry:c104 : 1

m46*m20*m183*0.1

nodelay

--

true

0

false

PMID: 16357866 The recruitment of these adaptor molecules to the receptor complex results in binding of TRAF6 and RIP1 to TRIF.

Go back
754.0, 1019.0
30.0, 30.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e42 MO000016591 e64 e93

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c152 : 1
stoichiometry:c174 : 1
stoichiometry:c262 : 1
stoichiometry:c106 : 1

m32*m47*0.1

nodelay

--

true

0

false

PMID: 16357866 The recruitment of these adaptor molecules to the receptor complex results in binding of TRAF6 and RIP1 to TRIF, leading to the late-phase activation of NF-kappaB. PMID: 16357866, 12659860 Expression of A20 inhibits TLR4-mediated NF-kappaB activation by regulating MEKK-1 kinase activity. PMID: 16357866, 12433373, 12433365 ectopic expression of SOCS1 in a macrophage cell line inhibits LPSinduced NF-kappaB activation. PMID: 16357866 A1 inhibits endothelial activation by inhibiting NF-kB activity.

Go back
926.0, 1291.0
30.0, 30.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c28 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16357866, 15814722 The recruitment of these adaptor molecules to the receptor complex results in inding of TRAF6 and RIP1 to TRIF, leading to the late-phase activation of NF-kappaB, which contributes to the induction of IFN-beta.

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278.0, 707.0
30.0, 30.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000019331 MO000016608

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c83 : 1
stoichiometry:c101 : 1
stoichiometry:c113 : 1

m20*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16357866 TRAF family member-associated NF-kappaB activator (TANK) binding kinase 1 (TBK1) and IKKepsilon (also known as IKKi) interact with TRIF.

Go back
502.0, 1311.0
30.0, 30.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e21

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m977*m21*0.1

nodelay

--

true

0

false

PMID: 16357866, 12692549 TRAF family member-associated NF-kappaB activator (TANK) binding kinase 1 (TBK1) and IKKepsilon (also known as IKKi) interact with TRIF and mediate activation of IRF3.

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666.0, 1487.0
30.0, 30.0

p37

p37

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e80

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c118 : 1

m87*0.1

nodelay

--

true

0

false

PMID: 16357866, 11244049 Once inside the nucleus, IRF3 controls IFNbeta transcription by recruiting the coactivators, p300 and CBP.

Go back
858.0, 1511.0
30.0, 30.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e44 MO000019984 MO000017462

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m49*m4512*m2282*0.1

nodelay

--

true

0

false

PMID: 16357866, 11244049 Once inside the nucleus, IRF3 controls IFNbeta transcription by recruiting the coactivators, p300 and CBP.

Go back
926.0, 1419.0
30.0, 30.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e82

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 16357866, 11244049 Once inside the nucleus, IRF3 controls IFNbeta transcription by recruiting the coactivators, p300 and CBP.

Go back
354.0, 115.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 MO000016882

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m13*m155666*0.1

nodelay

--

true

0

false

PMID: 16357866, 12072369, 11276205 LPS associates with the heat shock proteins, Hsp70 and Hsp90, chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF5).

Go back
1034.0, 1475.0
30.0, 30.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c233 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16357866, 12692549 activation of IRF3, leading to the induction of IFNb.

Go back
278.0, 1435.0
30.0, 30.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m21*m63*0.1

nodelay

--

true

0

false

PMID:16357866, 15611223 NF-kappaB activating kinase associating protein (NAP1) also interacts with TRIF and TBK1 to stimulate IFNbeta production through activation of IRF3.

Go back
430.0, 1379.0
30.0, 30.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e46

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1

m977*m64*0.1

nodelay

--

true

0

false

PMID:16357866, 15611223 NF-kappaB activating kinase associating protein (NAP1) also interacts with TRIF and TBK1 to stimulate IFNbeta production through activation of IRF3.

Go back
1098.0, 1479.0
30.0, 30.0

p43

p43

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e48 e47

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c134 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 16357866, 15699069 Mice that are deficient in Dok1 and Dok2 show an increase in TNFalpha and NO production in peritoneal and bone-marrow derived macrophages, as compared to wild-type cells.

Go back
1158.0, 1475.0
30.0, 30.0

p44

p44

cso30:i:ME_ChangeInMaterialConcentration

cso30:i:CC_Cytosol

--

e48 e47

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c141 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16357866, 15699069 Mice that are deficient in Dok1 and Dok2 show an increase in TNFalpha and NO production in peritoneal and bone-marrow derived macrophages, as compared to wild-type cells.

Go back
606.0, 1279.0
30.0, 30.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c144 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16357866, 10066820 inhibition of PI3K results in the induction of NOS.

Go back
554.0, 1399.0
30.0, 30.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514 e41

MO000021199

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c148 : 1
stoichiometry:c146 : 1

m93479*0.1

nodelay

--

true

0

false

PMID: 16357866, 10066820 inhibition of PI3K results in the induction of NOS.

Go back
738.0, 379.0
30.0, 30.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019406 e15

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m3973*m15*0.1

nodelay

--

true

0

false

PMID: 16357866 In unstimulated cells, Tollip forms a complex with IRAK.

Go back
630.0, 1227.0
30.0, 30.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c149 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 16357866, 10788611 PI3K has been shown to inhibit the expression of NOS2 in human astrocytes.

Go back
482.0, 835.0
30.0, 30.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e16 e75

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c163 : 1
stoichiometry:c206 : 1
stoichiometry:c159 : 1

m9*m82*0.1

nodelay

--

true

0

false

PMID: 16357866, 15935276, 9838078 PI3Ks are a family of kinases that catalyze the phosphorylation of phosphoinositides. The phosphorylated lipid products, phosphatidylinositol (PtdIns) 3,4-bisphosphate and PtdIns 3,4,5-triphosphate, then act as second messengers to activate downstream events, including activation of Akt. PMID: 16357866 SHIP1 negatively regulates LPS-induced activation of Akt downstream of PI3K.

Go back
786.0, 291.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 MO000016573 MO000022528 e63 MO000016569

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c172 : 1
stoichiometry:c189 : 1
stoichiometry:c18 : 1

m12*m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 16357866, 12691620 MyD88 is recruited to the TLR4 receptor through interaction with the TIR domain of TLR4. PMID: 16357866, 11544529 Upon LPS stimulation, TIRAP also associates with TLR4 via a TIR?TIR interaction, and is essential for MyD88-dependent signaling. PMID: 16357866, 15004556 The inhibitory effect of ST2 is the result of the interaction between its TIR domain and the TIR domains of MyD88 and TIRAP, thus sequestering these critical adaptors during LPS signaling. PMID: 16357866 IRAK-M plays a negative role in TLR4 signaling by preventing the dissociation of IRAK4 and MyD88 and thus preventing the formation of the IRAK?TRAF6 complex.

Go back
558.0, 291.0
30.0, 30.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044786 MO000016573 MO000022528

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m22456*m1572*m6810*0.1

nodelay

--

true

0

false

PMID: 16357866 The inhibitory effect of ST2 is the result of the interaction between its TIR domain and the TIR domains of MyD88 and TIRAP.

Go back
494.0, 291.0
30.0, 30.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000022200 e11

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m72*m6500*m11*0.1

nodelay

--

true

0

false

PMID: 16357866, 15852007 The complex of RP105 and MD1 interacts with TLR4/MD2, impairing its ability to bind LPS.

Go back
602.0, 1583.0
30.0, 30.0

p52

p52

cso30:i:ME_Ubiquitination

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e88

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c182 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 16357866, 15107846 TRIAD3A, which contains structural features reminiscent of an E3 ubiquitinprotein ligase and promotes degradation of the receptor by targeting the receptor for ubiquitination and proteolytic degradation.

Go back
666.0, 1531.0
30.0, 30.0

p53

p53

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

MO000061958 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m36851*m74*0.1

nodelay

--

true

0

false

PMID: 16357866, 15107846 TRIAD3A, which contains structural features reminiscent of an E3 ubiquitinprotein ligase and promotes degradation of the receptor by targeting the receptor for ubiquitination and proteolytic degradation.

Go back
1142.0, 99.0
30.0, 30.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 16357866 The binding of IRAK4 to the receptor complex facilitates the transphosphorylation of IRAK1.

Go back
1074.0, 695.0
30.0, 30.0

p55

p55

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e74

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c193 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 16357866, 10882101, 15836773 TAB2 links TAK1 to TRAF6 and facilitates the ubiquitination of TRAF6.

Go back
1402.0, 591.0
30.0, 30.0

p56

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e23

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c195 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16357866 Although TAK1 phosphorylation occurs at the membrane and is dependent on the formation of the TRAF6?TAK1?TAB1?TAB2?TAB3 complex, it does not become active until the complex translocates to the cytoplasm.

Go back
1230.0, 675.0
30.0, 30.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c196 : 1

m77*0.1

nodelay

--

true

0

false

PMID; 16357866, 12242293 Although TAK1 phosphorylation occurs at the membrane and is dependent on the formation of the TRAF6?TAK1?TAB1?TAB2?TAB3 complex, it does not become active until the complex translocates to the cytoplasm.

Go back
1146.0, 875.0
30.0, 30.0

p58

p58

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e73 MO000061452

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c198 : 1
stoichiometry:c194 : 1

m80*m36350*0.1

nodelay

--

true

0

false

PMID: 16357866 TIFA promotes the oligomerization of TRAF6 and enhances the autoubiquitinating activity of TRAF6.

Go back
1158.0, 1247.0
30.0, 30.0

p59

p59

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000016899 e16 e76

e30 e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c80 : 1
stoichiometry:c201 : 1
stoichiometry:c154 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 16357866 ubiquitin-directed proteasome-mediated degradation of the IkB members. PMID: 16357866, 11828002 FADD-/- MEFs stimulated with LPS demonstrate increased IkappaB-beta degradation compared to FADD+/+ cells, indicating that the role of FADD is upstream of IkappaB degradation. PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
282.0, 207.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 MO000041132 e12

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18998*m19005*m12*0.1

nodelay

--

true

0

false

PMID: 16357866, 14519765 MyD88-independent signaling begins with recruitment of the adaptor molecule, TRAM, to the cytoplasmic domain of TLR4. PMID: 16357866, 14519765, 14556004 TRAM is specific to the TLR4 signaling pathway and was cloned as a TLR4-binding protein in yeast that facilitates the binding of TRIF to the receptor complex by forming heterodimers with TRIF.

Go back
478.0, 1099.0
30.0, 30.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017583 e41

e75 MO000017113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c205 : 1
stoichiometry:c200 : 1
stoichiometry:c204 : 1

m347277*m45*0.1

nodelay

--

true

0

false

PMID: 16357866, 15935276, 9838078 PI3Ks are a family of kinases that catalyze the phosphorylation of phosphoinositides. The phosphorylated lipid products, phosphatidylinositol (PtdIns) 3,4-bisphosphate and PtdIns 3,4,5-triphosphate, then act as second messengers to activate downstream events, including activation of Akt.

Go back
490.0, 895.0
30.0, 30.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017113 MO000000048 e16

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c208 : 1

m157532*m9*0.1

nodelay

--

true

0

false

PMID: 16357866, 15935276, 9838078 PI3Ks are a family of kinases that catalyze the phosphorylation of phosphoinositides. The phosphorylated lipid products, phosphatidylinositol (PtdIns) 3,4-bisphosphate and PtdIns 3,4,5-triphosphate, then act as second messengers to activate downstream events, including activation of Akt. PMID: 16357866 SHIP1 negatively regulates LPS-induced activation of Akt downstream of PI3K.

Go back
262.0, 1107.0
30.0, 30.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e41

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m1572*m45*0.1

nodelay

--

true

0

false

Go back
258.0, 1655.0
30.0, 30.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e41 MO000019394

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c213 : 1
stoichiometry:c215 : 1

m45*m3961*0.1

nodelay

--

true

0

false

Go back
430.0, 1431.0
30.0, 30.0

p64

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c216 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16357866, 11244049 IRF3 is a member of a family of transcription factors that are involved in the induction of type I IFNs that translocate to the nucleus upon phosphorylation and dimerization.

Go back
582.0, 1439.0
30.0, 30.0

p65

p65

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 16357866, 11244049 IRF3 is a member of a family of transcription factors that are involved in the induction of type I IFNs that translocate to the nucleus upon phosphorylation and dimerization.

Go back
954.0, 927.0
30.0, 30.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e81 e16

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c221 : 1

m38*m88*0.1

nodelay

--

true

0

false

PMID: 16357866, 12941697 activation of JNK is dependent on interaction of the scaffolding protein JNK-interacting protein 3 (JIP3) with the cytoplasmic domain of TLR4. PMID: 16357866 SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
1010.0, 1711.0
30.0, 30.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000019394 MO000030898

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m3961*m10459*0.1

nodelay

--

true

0

false

PMID: 16357866, 12941697 activation of JNK is dependent on interaction of the scaffolding protein JNK-interacting protein 3 (JIP3) with the cytoplasmic domain of TLR4.

Go back
966.0, 863.0
30.0, 30.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 MO000000041 e16 e47 e48

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c228 : 1

m36*m89*0.1

nodelay

--

true

0

false

PMID: 16357866, 11163183, 7937886 Tpl2 (also known as Cot) has been implicated in LPS-induced ERK activation in macrophages. Tpl2 has been shown to coordinate with the Ras pathway to induce activation of ERK in COS-1 monkey kidney cells. PMID: 16357866, 15699069 Overexpression of Dok1 or Dok2 inhibits LPS-induced ERK activation. SHIP1 also inhibits LPS-induced MAPK activation and IkB-a degradation.

Go back
726.0, 1411.0
30.0, 30.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 16357866, 12356687 the MyD88-independent pathway induces expression of IFN-inducible genes, such as IP10 and glucocorticoid-attenuated response gene 16 (GARG16), through activation of the transcription factor, IFN regulatory factor 3 (IRF3).

Go back
974.0, 399.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 e17 MO000039077 e69 MO000000212

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c25 : 1
stoichiometry:c150 : 1
stoichiometry:c187 : 1
stoichiometry:c270 : 1
stoichiometry:c26 : 1

m15*m17*m17258*m183*0.1

nodelay

--

true

0

false

PMID: 16357866, 12538665 The binding of IRAK4 to the receptor complex facilitates the transphosphorylation of IRAK1, inducing IRAK1 kinase activity. PMID: 16357866, 12538665 MyD88s inhibits TLR4 signaling by preventing the recruitment of IRAK4 to MyD88 in the receptor complex, thus abolishing phosphorylation and activation of IRAK1.

Go back
770.0, 1415.0
30.0, 30.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 16357866, 12356687 the MyD88-independent pathway induces expression of IFN-inducible genes, such as IP10 and glucocorticoid-attenuated response gene 16 (GARG16), through activation of the transcription factor, IFN regulatory factor 3 (IRF3).

Go back
1430.0, 1283.0
30.0, 30.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000016899

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c257 : 1

m1572*m1814*0.1

nodelay

--

true

0

false

PMID: 16357866, 10880445 binding of FADD to the DD of MyD88 and subsequent recruitment of caspase 8.

Go back
778.0, 1223.0
30.0, 30.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c243 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 16357866, 15852007 RP105-mediated inhibition of IL-8 production was the result of inhibition of NF-kB activity.

Go back
526.0, 1211.0
30.0, 30.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e86

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c242 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 16357866, 15852007 RP105-mediated inhibition of IL-8 production was the result of inhibition of NF-kB activity.

Go back
878.0, 1659.0
30.0, 30.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000066718

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c247 : 1
stoichiometry:c248 : 1

m3961*m41575*0.1

nodelay

--

true

0

false

PMID: 16357866, 15866876 SIGIRR has recently been shown to interact with TLR4 through its TIR domain to attenuate recruitment of downstream signaling molecules.

Go back
470.0, 1707.0
30.0, 30.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000061958 MO000019394

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c249 : 1

m36851*m3961*0.1

nodelay

--

true

0

false

PMID: 16357866 TRIAD3 was identified as a RING-finger protein that interacts with the cytoplasmic tail of several TLRs, including TLR4.

Go back
1166.0, 367.0
30.0, 30.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016569 MO000000212

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m1571*m183*0.1

nodelay

--

true

0

false

PMID: 16357866 IRAK-M can interact with both MyD88 and TRAF6.

Go back
902.0, 275.0
30.0, 30.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000016569

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m1572*m1571*0.1

nodelay

--

true

0

false

PMID: 16357866 IRAK-M can interact with both MyD88 and TRAF6.

Go back
1394.0, 1419.0
30.0, 30.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 MO000016900

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m99*m1815*0.1

nodelay

--

true

0

false

PMID: 16357866, 10880445 binding of FADD to the DD of MyD88 and subsequent recruitment of caspase 8.

Go back
518.0, 1067.0
30.0, 30.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e94 e41

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c266 : 1
stoichiometry:c268 : 1

m102*m45*0.1

nodelay

--

true

0

false

PMID: 16357866, 15100319 Inhibition of PI3K leads to a reduction in the activation of NF-kB and the MAPKs, p38 and p44/42.

Go back
1238.0, 283.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c27 : 1

m183*0.1

nodelay

--

true

0

false

PMID: 16357866, 8837778 The autophosphorylation and activation of IRAK1 results in the ability to bind TNF receptor-associated factor-6 (TRAF6).

Go back
562.0, 1067.0
30.0, 30.0

p80

p80

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 e41

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c269 : 1

m103*m45*0.1

nodelay

--

true

0

false

PMID: 16357866, 15100319 Inhibition of PI3K leads to a reduction in the activation of NF-kB and the MAPKs, p38 and p44/42.

Go back
1130.0, 287.0
30.0, 30.0

p9

p9

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e19 MO000016569

e22 e17 MO000039077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c188 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c151 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 16357866 The complex of IRAK1 and TRAF6 dissociates from the receptor. PMID: 16357866 IRAK-M plays a negative role in TLR4 signaling by preventing the dissociation of IRAK4 and MyD88 and thus preventing the formation of the IRAK?TRAF6 complex.

Go back
445.0, 89.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 141.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.5807171265117, 1013.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.04180165379375, 733.7964495872627

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 557.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
382.0, 529.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0437687993774, 614.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 1051.014069158532

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1041.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 658.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1093.0, 314.8903372210088

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.8991484254357, 441.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.4748979049598, 77.85059665867112

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.7405330957081, 443.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.5232383463386, 445.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.0, 466.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 737.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.0, 1326.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.0, 1341.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.0, 1286.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.68333665795154, 1411.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 1495.9922778767136

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.0, 1502.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 153.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.1530859662622, 1492.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.8599434057004, 1478.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 1463.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 1400.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 1425.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
303.36501282900446, 1325.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
315.7416285831831, 1456.0167267737704

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 1419.3173289177635

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.0, 1344.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 1395.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.5321520841902, 85.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.0, 1395.5150582239837

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 1178.0

c131

c131

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
582.0, 1185.0

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
864.0, 1360.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1128.0, 1506.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.058360077179, 852.857443965508

c135

c135

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1004.7996849230261, 852.9192478900785

c136

c136

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1124.133203693502, 1433.0

c137

c137

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1109.0, 1380.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
863.859055284951, 1295.0524696231685

c139

c139

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
378.0, 145.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.7065845744225, 1297.5037389376662

c140

c140

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1188.0, 1504.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.0, 1433.0

c142

c142

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1118.0, 1380.0

c143

c143

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
621.0, 1309.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.9115249081194, 1363.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.7339445046937, 1307.5183473879074

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 1195.0

c147

c147

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
565.0, 1195.0

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
660.0, 1245.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.0, 263.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.1554175279994, 386.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.9349894126537, 315.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 998.0

c152

c152

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
582.0, 1192.0

c153

c153

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
946.8293503176901, 1124.1665302396916

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 394.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.9051906147945, 397.2279907751137

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 372.1117762963229

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0, 850.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.2850231591362, 865.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 282.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 932.8174109113824

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
606.0, 636.805465760937

c161

c161

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
617.0, 697.8729529568841

c162

c162

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
514.9469402979321, 769.0

c163

c163

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
453.0, 1056.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.5280730250482, 707.8848609311901

c165

c165

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
617.0, 757.0

c166

c166

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
617.0, 765.0

c167

c167

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
549.0, 328.05882352941177

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.7924678801467, 279.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 309.31519189844283

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.9355982368307, 309.01305509406353

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 321.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 313.4341029463384

c172

c172

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
783.8557160067836, 983.064638001873

c173

c173

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
787.9924474796915, 1025.0

c174

c174

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
787.76170178708, 1030.0

c175

c175

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
468.0, 303.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.0, 326.84844214594295

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 260.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 233.16041660595116

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.0, 239.10445600046506

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 136.96104495853024

c180

c180

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
453.0, 1577.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 1601.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.9999986223355, 1627.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 1568.9889426346601

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.9633888627242, 1532.7644853308216

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 1547.4035260826884

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
971.0, 368.0

c187

c187

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1084.0, 306.93029285288685

c188

c188

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
819.9926103203804, 307.243028454284

c189

c189

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
310.0267946250703, 243.91266410637064

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.0, 114.04774765311672

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 113.60800678397965

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.0, 606.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 710.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.6568542494924, 854.6568542494924

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1366.52380597346, 621.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1210.0, 690.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.0, 829.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1132.0, 912.5285977302406

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1089.0, 733.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 66.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.8965115279171, 243.32646622191055

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.7339445046936, 1007.5183473879075

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.0, 1277.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1191.4664898274966, 1271.9958577794678

c202

c202

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
617.0, 768.0

c203

c203

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
493.0, 992.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.9539382695573, 1132.3432779342181

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
452.0, 872.4432671425367

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 869.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 910.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
516.0979096335776, 770.0

c209

c209

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
320.0, 222.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.7945204458073, 273.6380678767719

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.8344566477708, 1126.6190395406536

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 1105.9842018608185

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.9999987575534, 1627.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.7003328887722, 1177.659560630907

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.0, 1618.9999097744742

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 1446.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.0, 1450.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.0, 1469.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.0, 1504.9531617649475

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.0, 237.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.0, 930.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.3730830011045, 948.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0680797695768, 1627.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 1559.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.0, 1658.9518772219917

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.3631309049416, 964.8830117427284

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 762.0

c226

c226

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
925.0, 878.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.3802213849306, 788.6943006071581

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.5791620746932, 885.5605277279369

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
899.0, 414.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.0, 759.0

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
986.0205056921436, 896.8676308164434

c231

c231

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
987.2649110640674, 896.7947331922021

c232

c232

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1064.0, 1504.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 1392.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
751.0769230769231, 1448.3846153846155

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 1452.7611400011626

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.4043756496454, 1433.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.0, 1391.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 535.1002794011677

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.0, 980.5118853505207

c24

c24

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
731.0, 274.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 1298.045713539377

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 1226.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.5631664759627, 1253.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0950515759703, 1200.0

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.4808531707783, 1234.8349313637643

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.0, 1627.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 1591.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.5245432483571, 1654.9917460275453

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.0, 1657.6746825652904

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.1919447278764, 274.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.0, 1605.197769023179

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.0, 332.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 393.6938822372374

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1196.0, 368.22446461232846

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 276.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
939.8143047067587, 294.71366331288567

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.0, 305.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1275.5753213254563, 1303.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.0, 1376.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1270.0, 1434.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 284.1554175279993

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1281.4063403746636, 1440.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 987.845410946568

c261

c261

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
675.0, 1034.0

c262

c262

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
675.0, 1042.0

c263

c263

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
523.0, 1017.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.8644734461474, 1021.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.5298221281347, 1104.5894663844042

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
567.0, 1104.9362698337625

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 964.9166915142761

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 921.99726740951

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.0, 255.57180301734928

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1011.6921915811266, 420.19776902317903

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 1321.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1267.8911513906571, 693.3151918984429

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 66.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1165.6568542494924, 250.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0, 306.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1025.1554175279994, 242.57770876399965

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 1007.0

c33

c33

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1343.0, 388.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1169.0, 737.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1273.0, 440.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1255.0, 506.4256285830347

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1261.0, 481.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1258.0, 513.932754944306

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.5473041962108, 82.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1190.7433776766206, 774.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.9569472711262, 808.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1358.5970433718076, 517.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.9917483216825, 888.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0408995635705, 596.3995222713548

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 573.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.8224311589584, 444.4855782911503

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0, 533.2089120009301

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.7198375769518, 418.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 450.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 89.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 511.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 1200.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1099.5414552454888, 1013.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 1062.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1011.0, 758.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1174.027397260274, 1097.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1168.0, 1148.4632633294639

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1153.0, 1110.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1189.6568542494924, 1166.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 1217.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.0, 126.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.7873373466687, 1111.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.5699763999032, 1137.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 999.7395940823308

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 649.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.9171604165009, 696.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.947271486969, 696.9169928638811

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1001.0, 758.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.7811348571815, 748.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.0, 844.3373412826452

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.3874126689176, 781.8167374224624

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.0, 126.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.5093580761338, 902.7585397014369

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.0, 907.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 628.0938134100054

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.0, 633.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.006706052951, 583.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.0, 553.9889426346601

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.2864409730729, 536.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.2262200348343, 539.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 991.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.0, 600.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 126.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1195.0437687993774, 1240.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.0, 1087.8605857057737

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 1084.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.89309978211486, 726.303447670441

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 490.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.2018798841383, 518.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.799221533699, 658.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 699.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 513.6006381480884

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.0, 656.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.0, 129.00251106411423

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 915.0638092102944

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
694.0, 884.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
845.0, 1305.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.0, 1260.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 1187.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.0, 1200.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.0, 1200.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.997325954875, 1178.2068273953846

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
641.8886946143962, 378.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0, 884.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back