1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16419614.csml convertedTime:2009.07.01.10:53

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors. II. Distribution and pathways involved in TLR signalling.
Authors Sandor F, Buc M.
Affiliation Department of Immunology, Comenius University School of Medicine, Bratislava,Slovakia.
Abstract The innate immune system senses invading microorganisms by a phylogeneticallyconserved family of proteins--TLRs. They are expressed in several types of cellsthat represent a route of entry of pathogens into the host organism and that cancontribute to protection against infection. Except for cells of the immunesystem, TLRs are present in epithelial cells of the skin, respiratory,intestinal, and genitourinary tracts that form the first protective barrier toinvading pathogens. Polarized regulation of TLR expression in epithelial cellsexplains why pathogenic but not commensal bacteria elicit inflammatoryresponses. TLR-induced intracellular signalling pathways show remarkablecomplexity: apart from a common signalling pathway, additional signallingpathways specific for each of the TLRs are responsible for a fine tuning of theimmune response, thus securing effective pathogen-directed biological responses.
PMID 16419614
Model Abstract

Entity

G010228:IFN-beta G010291:G-CSF G010384:IRF-1 G010514:iNOS G010657:IL-12 p40 G010693:Tlr4 G010962:TLR2 G029941:COX2 MO000000011:ERK MO000000023:JNK MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000166:Rac1 [activated} MO000000193:RelA-p65 MO000000212:TRAF6 MO000000214:IL-1 MO000000215:IkappaB MO000000276:AP-1 MO000000289:TNF-alpha MO000000342:MAPK{p} MO000007384:IL-6 MO000007694:IRF-3 MO000007702:IRF-7 MO000013119:STAT1 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016656:STATs MO000016660:IFNbeta MO000016665:IFNgamma MO000016882:LPS MO000016894:MAPK MO000016922:CD40 MO000019331:TBK1 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000019406:Tollip MO000019704:STAT1{p} MO000021062:superoxide MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039097:Tollip:IRAK MO000041125:TRIF MO000041132:TRAM MO000041456:IRF-3{p} MO000042012:TLR9 e1: e10: e100:G-CSF: NF-IL6 e101:NF-IL6 e102:PGE2 e103:ISRE {activated}: IRF-3{p} {nucleus} e104:IP-10 e105:STATs {activated} e11:LPS: TLR4: TIRAP e12:LPS: TLR4 e13:LPS: TLR4: TIRAP: MyD88 e14:IL-1: IL-1R: MyD88: IRAK {p}: Tollip e15:polyI:C e16:polyI:C: TLR3 e17:flagellin: TLR5 e18:IL-1R e19:IL-1: IL-1R e2: e20:TLR ligand: TLR: MyD88 e21:IL-1: IL-1R: MyD88 e22:TLR ligand: TLR: MyD88: IRAK: Tollip e23:IL-1: IL-1R: MyD88: IRAK: Tollip e24:TLR ligand: TLR: MyD88: IRAK {p}: TRAF6 e25:IL-1: IL-1R: MyD88: IRAK {p}: TRAF6 e26:NF-kappaB {activated} e27:TLR ligand: TLR: MyD88: IRAK {p}: Tollip e28:AP-1 {activated} e29:LPS: TLR4: TRAM e3: e30:LPS: TLR4: TRAM: TRIF e31:TLR ligand: TLR: MyD88: IRAK {p} e32:IL-1: IL-1R: MyD88: IRAK {p} e33:LPS: TLR4: TIRAP: MyD88: IRAK: Tollip e34:LPS: TLR4: TIRAP: MyD88: IRAK [p}: Tollip e35:LPS: TLR4: TIRAP: MyD88: IRAK [p} e36:TAK1 {activated} e37:LPS: TLR4: TIRAP: MyD88: IRAK [p}: IRAK4: TRAF6 e38:IKK-alpha:IKK-beta:IKK-gamma e39:IKK-alpha:IKK-beta:IKK-gamma {activated} e4: e40:IkappaB {activated} e41:TLR1: TLR2 e42:BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p}: TRAF6 e43:BLPs: TLR1: TLR2: TIRAP e44:BLPs: TLR1: TLR2 e45:BLPs e46:BLPs: TLR1: TLR2: TIRAP: MyD88 e47:BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK: Tollip e48:BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p}: Tollip e49:BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p} e5:TLR ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand: TLR e60: e61: e62: e63:dsRNA: TLR3 e64:dsRNA: TLR3: TRIF e65:polyI:C: TLR3: TRIF e66:polyI:C: TLR3: TRIF: IRF-3 e67:dsRNA: TLR3: TRIF: TRAF6 e68:IRF-7 [activated} e69:IRF-3{p} [nucleus} e7: e70:ISRE e71:ISRE: IRF-3{p} {nucleus} e72:IFN-alpha e73:BLPs: TLR1: TLR2: TIRAP: MyD88: Rac1 {activated}: PI3K e74:RelA-p65 {activated} e75:AKT {activated} e76:RelA-p65 {nucleus} e77:CpG DNA e78:CpG DNA: TLR9 e79:CpG DNA: TLR9: MyD88 e8: e80:IFN inducible genes e81:JNK {activated} e82:ERK {activated} e83:cytokines e84:TLR agonist e85:IL23 e86:Delta-4 e87:TLR3 agonist e88:TLR4 agonist e89:TLR8 agonist e9: e90:immunoglobulin light chain genes e91:NF-IL6 {p} e92:IL-6 e93:IL-6: NF-IL6 e94:TNF: NF-IL6 e95:TNF e96:NF-IL6 e97:IL-8 e98:G-CSF e99:IL-8: NFIL6

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
490.0, 1290.0
28.5, 28.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p56 p58 p67

p99

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
620.0, 1408.0
24.0, 24.0

G-CSF

--

G010291

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

--

true true true true

csml-variable:Double

m93274

10

false

infinite

0

unit false false false
TRANSFACG010291

--

Go back
723.0, 1371.0
26.0, 26.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p95

--

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
679.0, 1407.0
26.0, 26.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p96

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
507.0, 1383.0
26.0, 26.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p76

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
793.0, 1325.0
29.0, 29.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p9 p10

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
785.0, 1273.0
30.0, 30.0

TLR2

--

G010962

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p7 p8

--

true true true true

csml-variable:Double

m93848

10

false

infinite

0

unit false false false
TRANSFACG010962

--

Go back
522.0, 1270.0
28.0, 28.0

COX2

--

G029941

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p90

--

true true true true

csml-variable:Double

m108639

10

false

infinite

0

unit false false false
TRANSFACG029941

--

Go back
619.0, 1022.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
671.0, 914.0
31.0, 31.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69 p70 p71 p73 p74

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
329.0, 780.0
28.0, 28.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
360.0, 823.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
848.0, 834.0
31.0, 31.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21 p31 p36 p50 p53

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
332.0, 743.0
21.0, 21.0

Rac1 [activated}

--

MO000000166

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000166

--

Go back
370.0, 933.0
26.0, 26.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
913.0, 636.0
27.5, 27.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17 p32 p43 p49

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1290.0, 860.0
28.0, 28.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p82 p98

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
820.0, 742.0
32.0, 32.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
921.0, 1064.0
28.0, 28.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1289.0, 1301.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p10

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
955.0, 1455.0
26.0, 26.0

MAPK{p}

--

MO000000342

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87

p88

true true true true

csml-variable:Double

m273

10

false

infinite

0

unit false false false
TRANSPATHMO000000342

--

Go back
909.0, 1669.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
422.0, 629.0
26.0, 26.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p51 p52

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
516.0, 727.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
688.0, 1500.0
24.0, 24.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p94

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
904.0, 411.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p12 p13 p39 p65

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
751.0, 602.0
32.0, 32.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p44

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
579.0, 674.0
32.0, 32.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
621.0, 1513.0
22.0, 22.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93 p98

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
301.0, 1381.0
21.0, 21.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p99

p94

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1223.0, 1313.0
26.0, 26.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
865.0, 107.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p84 p87 p90 p91 p93 p94

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1087.0, 1499.0
26.0, 26.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
442.0, 1534.0
28.0, 28.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66

--

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
568.0, 616.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1221.0, 1212.0
28.0, 28.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
867.0, 253.0
25.0, 25.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1150.0, 516.0
27.0, 27.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
473.0, 256.0
27.0, 27.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p45

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
249.0, 1012.0
28.0, 28.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
978.0, 600.0
28.0, 28.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p27 p30 p42

--

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
776.0, 1460.0
23.0, 23.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

p95 p96 p97

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
1007.0, 1239.0
26.0, 26.0

superoxide

--

MO000021062

cso30:c:Protein

cso30:i:CC_CellComponent

--

p75

--

true true true true

csml-variable:Double

m117348

10

false

infinite

0

unit false false false
TRANSPATHMO000021062

--

Go back
133.0, 1008.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
496.0, 107.0
30.5, 30.5

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
958.0, 300.0
27.5, 27.5

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p38

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
886.0, 510.0
28.0, 28.0

Tollip:IRAK

--

MO000039097

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15 p28 p40

true true true true

csml-variable:Double

m17273

10

false

infinite

0

unit false false false
TRANSPATHMO000039097

--

Go back
784.0, 339.0
29.0, 29.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p46 p47

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
807.0, 309.0
26.0, 26.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
418.0, 673.0
34.0, 34.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51 p52

p55

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
619.0, 1571.0
25.0, 25.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
210.84960652916135, 207.12182290365567
993.9237400436089, 1434.0374080689273

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
276.8168958473435, 302.14081751540294
910.217175251726, 1272.3105331426816

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
623.0, 1331.5
34.99100025713552, 9.914116739521731

G-CSF: NF-IL6

--

e100

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p86

p89

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
606.0, 1124.5
26.560000000000002, 19.920000000000005

NF-IL6

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
578.0, 1310.0
35.865051903114185, 19.128027681660903

PGE2

--

e102

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p91

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
498.875, 1337.5
60.0, 17.0

ISRE {activated}: IRF-3{p} {nucleus}

--

e103

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p92

p56

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
669.0, 1453.0
29.0, 29.0

IP-10

--

e104

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p97

--

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
Affymetrix1418930_at
EnsemblENSMUSG00000034855
MGDCxcl10
ProteomeHumanPSD/Cxcl10
RefSeqNM_021274
TRANSFACG001062
UnigeneMm.263514

--

Go back
653.0, 1501.0
22.0, 22.0

STATs {activated}

--

e105

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93 p98

--

true true true true

csml-variable:Double

m110

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
991.875, 231.5
32.25, 45.0

LPS: TLR4: TIRAP

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
922.625, 245.5
27.319071821363107, 33.451924679220134

LPS: TLR4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3 p24

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1059.875, 219.5
32.25, 45.0

LPS: TLR4: TIRAP: MyD88

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p28

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1142.875, 1045.5
34.751559919251235, 48.49054872453661

IL-1: IL-1R: MyD88: IRAK {p}: Tollip

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p27

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
433.5, 112.25
35.033641715727505, 19.852396972245586

polyI:C

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
435.625, 211.5
29.8993084485919, 36.61139810031661

polyI:C: TLR3

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p47

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
244.625, 1064.5
29.27874520913181, 35.851524745875686

flagellin: TLR5

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1146.0, 860.0
28.0, 28.0

IL-1R

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
1144.625, 894.5
31.099608398600232, 38.08115314114314

IL-1: IL-1R

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p13

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
210.84960652916135, 207.12182290365567
993.9237400436089, 1434.0374080689273

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1148.875, 597.5
29.606395668930077, 41.311249770600114

TLR ligand: TLR: MyD88

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1143.875, 939.5
32.25, 45.0

IL-1: IL-1R: MyD88

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p15

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1143.875, 647.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK: Tollip

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p18

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1143.875, 991.5
32.25, 45.0

IL-1: IL-1R: MyD88: IRAK: Tollip

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p19

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1151.875, 805.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK {p}: TRAF6

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p20 p74

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1146.875, 1159.5
32.25, 45.0

IL-1: IL-1R: MyD88: IRAK {p}: TRAF6

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p21 p73

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
848.0, 886.0
31.0, 31.0

NF-kappaB {activated}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p21 p31 p36 p50 p53

p79

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1143.875, 699.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK {p}: Tollip

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p26

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
874.0, 1110.0
28.0, 28.0

AP-1 {activated}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
812.875, 224.5
30.829555881813178, 43.017984951367225

LPS: TLR4: TRAM

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
230.7280813300335, 226.8744042820156
954.1667904418646, 1394.5322453122083

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
755.875, 243.5
30.829555881813178, 43.017984951367225

LPS: TLR4: TRAM: TRIF

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

p52 p53 p54

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1143.875, 751.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK {p}

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p16

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1143.875, 1103.5
32.25, 45.0

IL-1: IL-1R: MyD88: IRAK {p}

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p17

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1152.2124931180033, 207.5
39.9125068819967, 55.691870067902364

LPS: TLR4: TIRAP: MyD88: IRAK: Tollip

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

p29

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1147.875, 287.5
32.25, 45.0

LPS: TLR4: TIRAP: MyD88: IRAK [p}: Tollip

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1147.875, 339.5
32.25, 45.0

LPS: TLR4: TIRAP: MyD88: IRAK [p}

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p32

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
803.0, 646.0
32.0, 32.0

TAK1 {activated}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p44

p34

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1142.875, 399.5
32.25, 45.0

LPS: TLR4: TIRAP: MyD88: IRAK [p}: IRAK4: TRAF6

--

e37

cso30:c:Complex

cso30:i:CC_Extracellular

--

p32

p31 p33 p71

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
871.0, 701.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
751.0, 693.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p35

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
267.5032597116471, 261.4414216941452
880.6164336786378, 1325.398210487948

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
824.0, 786.0
32.0, 32.0

IkappaB {activated}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p36

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
249.5, 294.0
26.488251958006995, 32.43459423429428

TLR1: TLR2

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p37

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
245.875, 593.5
34.814690768948424, 48.57863828225362

BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p}: TRAF6

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
246.875, 331.5
32.25, 45.0

BLPs: TLR1: TLR2: TIRAP

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
274.875, 239.5
32.25, 45.0

BLPs: TLR1: TLR2

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p37

p38

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
132.5, 297.25
45.0, 25.5

BLPs

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
247.875, 385.5
29.606395668930077, 41.311249770600114

BLPs: TLR1: TLR2: TIRAP: MyD88

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p40 p60 p70

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
246.875, 435.5
32.376261699394384, 45.176179115434024

BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK: Tollip

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p41

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
241.875, 489.5
34.751559919251235, 48.49054872453661

BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p}: Tollip

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p42

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
246.875, 543.5
32.25, 45.0

BLPs: TLR1: TLR2: TIRAP: MyD88: IRAK {p}

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1305.0, 519.5
30.790861159929705, 20.014059753954307

TLR ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
395.61437667987815, 1098.859786712952
497.8846295926522, 448.66706922805633

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
449.3896253137213, 1109.492543994334
291.128070190117, 434.8477549807852

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
402.1044928943074, 1104.8481562201032
484.90439716379365, 436.6903302137548

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
403.0316523535118, 1105.7694438365872
483.050078245385, 434.8477549807852

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
395.61437667987815, 1098.859786712952
497.8846295926522, 448.66706922805633

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
395.61437667987815, 1098.859786712952
497.8846295926522, 448.66706922805633

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
403.0316523535118, 1105.7694438365872
483.050078245385, 434.8477549807852

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
759.0608846879221, 1283.117310009895
31.105096027823294, 27.979966650481593

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
677.4708522779531, 1412.0975763177555
88.08014862439842, 79.23073501768555

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
395.61437667987815, 1098.859786712952
497.8846295926522, 448.66706922805633

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1149.5, 552.0
29.33794367605399, 35.9240126645559

TLR ligand: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p12

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
512.9629824708803, 1298.2437249113873
15.767274654582488, 7.543571673757379

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
512.4364685396066, 1275.7470090780178
53.96767795556484, 96.52660630829469

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
535.0765675843808, 1338.5285416362588
8.424222900380846, 8.370871007765388

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
510.875, 239.5
32.25, 45.0

dsRNA: TLR3

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
547.875, 224.5
30.55335841438796, 42.6325931363553

dsRNA: TLR3: TRIF

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p46

p49 p69

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
370.875, 215.5
32.25, 45.0

polyI:C: TLR3: TRIF

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p48

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
326.875, 231.5
32.25, 45.0

polyI:C: TLR3: TRIF: IRF-3

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p48

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
610.875, 211.5
32.25, 45.0

dsRNA: TLR3: TRIF: TRAF6

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

p50 p51

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
520.0, 767.0
30.0, 30.0

IRF-7 [activated}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p58 p59

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
450.0, 1186.0
27.0, 27.0

IRF-3{p} [nucleus}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p57

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
278.0711087695365, 212.57384922649726
920.9055379865054, 1296.6352327892644

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
405.875, 1221.5
60.0, 13.0

ISRE

--

e70

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p57

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
397.875, 1283.5
60.0, 17.0

ISRE: IRF-3{p} {nucleus}

--

e71

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p57

p92

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
558.0, 1134.0
27.0, 27.0

IFN-alpha

--

e72

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59

--

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
240.875, 654.5
44.584189759588924, 62.21049733896127

BLPs: TLR1: TLR2: TIRAP: MyD88: Rac1 {activated}: PI3K

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

p62

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
370.0, 973.0
26.0, 26.0

RelA-p65 {activated}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

p63

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
372.0, 871.0
30.0, 30.0

AKT {activated}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

p61

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
415.0, 1343.0
26.0, 26.0

RelA-p65 {nucleus}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

p92

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
609.5, 1756.125
45.0, 15.75

CpG DNA

--

e77

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
579.625, 1583.5
33.10010831528078, 40.530744875854026

CpG DNA: TLR9

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p64

p65

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
527.875, 1597.5
32.25, 45.0

CpG DNA: TLR9: MyD88

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p67 p68 p66

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
281.3611391654567, 235.45820813661194
883.4356558893778, 1274.6247293697718

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
565.5, 1457.0
35.24221453287198, 18.795847750865054

IFN inducible genes

--

e80

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
675.0, 958.0
31.0, 31.0

JNK {activated}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69 p70 p71 p73 p74

p72

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
739.0, 1022.0
32.0, 32.0

ERK {activated}

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72

p22

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
810.5, 1223.0
34.930795847750865, 18.629757785467127

cytokines

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p23

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1264.5, 1165.25
45.0, 25.5

TLR agonist

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p23 p75

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
531.0, 1419.0
25.5, 25.5

IL23

--

e85

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p77

--

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSFACG025586

--

Go back
542.5, 1491.0
35.44982698961938, 18.906574394463668

Delta-4

--

e86

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p78

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
120.5, 1425.25
39.70142977291842, 22.497476871320433

TLR3 agonist

--

e87

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p76 p77 p78

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
119.5, 1463.25
38.313708999158955, 21.711101766190076

TLR4 agonist

--

e88

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p76 p77 p78

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
113.5, 1502.25
42.300252312867954, 23.970142977291843

TLR8 agonist

--

e89

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p76 p77 p78

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
290.134553554577, 258.3425670467266
879.4022875254016, 1257.9083454361455

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
796.5, 1192.0
37.110726643598625, 19.792387543252595

immunoglobulin light chain genes

--

e90

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p79

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
606.0, 1217.0
25.0, 25.0

NF-IL6 {p}

--

e91

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

p81 p80 p85 p86 p90 p91

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
Affymetrix212501_at
EnsemblENSG00000172216
HGNCCEBPB
InterProIPR004827
OMIM189965
PIRS12788
ProteomeHumanPSD/CEBPB
RefSeqNM_005194
TRANSFACT06595
TRANSPATHMO000054454
UnigeneHs.517106
UniProtP17676

--

Go back
658.5, 1122.125
35.82405345211582, 12.538418708240535

IL-6

--

e92

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p81

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
701.5, 1161.625
45.0, 12.75

IL-6: NF-IL6

--

e93

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p81

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
713.5, 1257.625
45.0, 12.75

TNF: NF-IL6

--

e94

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p80

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
756.5, 1237.125
39.96659242761692, 13.988307349665924

TNF

--

e95

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p80

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
776.5, 1374.0
38.564013840830455, 20.567474048442907

NF-IL6

--

e96

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p82 p83 p84

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
726.0, 1301.5
36.525612472160354, 12.783964365256125

IL-8

--

e97

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p85

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
668.0, 1366.5
32.605790645879736, 11.412026726057906

G-CSF

--

e98

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p86

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
708.0, 1330.5
39.74286448958602, 11.26047827204937

IL-8: NFIL6

--

e99

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p85

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1235.0, 517.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000019395

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m3962*0.1

nodelay

--

true

0

false

PMID: 16419614 The host defence against microorganisms mediated by TLRs relies mainly on signalling pathways induced by a common Toll-interleukin 1 receptor (TIR) domain and shows a high homology to that of the IL-1R (IL-1 receptor) family.

Go back
849.0, 1349.0
21.0, 21.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c22 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 16419614 Renal inflammation evoked by ischaemia markedly enhanced synthesis of TLR2 and TLR4 mRNA followed by significant elevation of protein expression in the distal tubular epithelium, the thin limb of Henle¡Çs loop and collecting ducts. This phenomenon was shown to be completely dependent on the action of IFN-gamma and TNF.

Go back
1219.0, 861.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000000214

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m18*m185*0.1

nodelay

--

true

0

false

PMID: 16419614 The host defence against microorganisms mediated by TLRs relies mainly on signalling pathways induced by a common Toll-interleukin 1 receptor (TIR) domain and shows a high homology to that of the IL-1R (IL-1 receptor) family.

Go back
1080.0, 606.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e6

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m1572*m6*0.1

nodelay

--

true

0

false

PMID: 16419614 Both TLRs and IL-1R interact with the intracellular adaptor protein MyD88 (myeloid differentiation factor).

Go back
1082.0, 949.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e19

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 16419614 Both TLRs and IL-1R interact with the intracellular adaptor protein MyD88 (myeloid differentiation factor).

Go back
1080.0, 658.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000039097

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m20*m17273*0.1

nodelay

--

true

0

false

PMID: 16419614 MyD88 afterwards recruits the serine/threonine kinase IRAK. PMID: 16419614 Before IL-1 treatment, Tollip is present in a complex with IRAK. Following the IL-1 stimulation, the recruitment of Tollip-IRAK complexes to the activated IL-1R occurs through the association of Tollip with IL-1R.

Go back
1064.0, 1002.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000039097

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c39 : 1
stoichiometry:c41 : 1

m21*m17273*0.1

nodelay

--

true

0

false

PMID: 16419614 MyD88 afterwards recruits the serine/threonine kinase IRAK. PMID: 16419614 Before IL-1 treatment, Tollip is present in a complex with IRAK. Following the IL-1 stimulation, the recruitment of Tollip-IRAK complexes to the activated IL-1R occurs through the association of Tollip with IL-1R.

Go back
1092.0, 804.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e31

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c274 : 1
stoichiometry:c44 : 1

m183*m32*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6.

Go back
1055.0, 1066.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e32

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c280 : 1
stoichiometry:c45 : 1

m183*m33*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6.

Go back
1223.0, 709.0
25.0, 25.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6. PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
1227.0, 1057.0
25.0, 25.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6. PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
868.0, 162.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16419614, 11544529, 11526399 In the process of analysing the MyD88-independent activation of the LPS-TLR4 signalling a novel adaptor protein named TIRAP or Mal was discovered (Fitzgerald et al. 2001; Horng et al., 2001).

Go back
914.0, 837.0
25.0, 25.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c54 : 1
stoichiometry:c51 : 1

m22*m25*0.1

nodelay

--

true

0

false

PMID: 16419614, 9374458 Its activation in turn leads to initiation of two distinct downstream pathways resulting in activation of NF-kappaB and AP-1 transcription factors (Muzio et al., 1997; 1998).

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918.0, 889.0
25.0, 25.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000058 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c55 : 1
stoichiometry:c53 : 1

m22*m26*0.1

nodelay

--

true

0

false

PMID: 16419614, 9374458 Its activation in turn leads to initiation of two distinct downstream pathways resulting in activation of NF-kappaB and AP-1 transcription factors (Muzio et al., 1997; 1998).

Go back
875.0, 1066.0
23.0, 23.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000276 e82

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c204 : 1
stoichiometry:c56 : 1

m219*m88*0.1

nodelay

--

true

0

false

PMID: 16419614, 9374458 Its activation in turn leads to initiation of two distinct downstream pathways resulting in activation of NF-kappaB and AP-1 transcription factors (Muzio et al., 1997; 1998). PMID: 16419614, 7622446 The activation of the AP-1 is induced through phosphorylation by the MAP kinases such as JNK and ERK, respectively, that are activated by means of TLR or IL-1R engagement (Karin, 1995).

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896.0, 1216.0
23.0, 23.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e83 e84

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c210 : 1
stoichiometry:c58 : 1

m89*m84*0.1

nodelay

--

true

0

false

PMID: 16419614, 12829592 The agonists of all TLRs expressed in neutrophils triggered cytokine release, superoxide generation, L-selectin shedding and increased phagocytosis of opsonised latex beads (Hayashi et al., 2003).

Go back
868.0, 310.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000041132

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m12*m19005*0.1

nodelay

--

true

0

false

PMID: 16419614 Hence, in LPS signalling, the TLR4 recruits two types of adaptors, TIRAP and TRAM, to its cytoplasmic domain that are indirectly connected to two effec-tive adaptors, MyD88 and TRIF, respectively.

Go back
786.0, 164.0
27.0, 27.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 MO000041125

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m30*m18998*0.1

nodelay

--

true

0

false

PMID: 16419614 Hence, in LPS signalling, the TLR4 recruits two types of adaptors, TIRAP and TRAM, to its cytoplasmic domain that are indirectly connected to two effec-tive adaptors, MyD88 and TRIF, respectively.

Go back
1228.0, 762.0
23.0, 23.0

p26

p26

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e27

e31 MO000019406

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c81 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
1226.0, 1112.0
27.0, 27.0

p27

p27

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e14

e32 MO000019406

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c80 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
1063.0, 301.0
25.0, 25.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000039097

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m13*m17273*0.1

nodelay

--

true

0

false

PMID: 16419614 The inhibition of NF-kappaB activation in response to IL-1, as well as TLR2 and TLR4 ligands (Fig. 1), is mediated through the ability of Tollip to suppress the activity of IRAK.

Go back
1227.0, 297.0
25.0, 25.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
960.0, 146.0
23.0, 23.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 MO000022528

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m12*m6810*0.1

nodelay

--

true

0

false

PMID: 16419614, 11544529, 11526399 In the process of analysing the MyD88-independent activation of the LPS-TLR4 signalling a novel adaptor protein named TIRAP or Mal was discovered (Fitzgerald et al. 2001; Horng et al., 2001).

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1227.0, 349.0
26.0, 26.0

p30

p30

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e34

e35 MO000019406

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
911.0, 789.0
25.0, 25.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e37

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m22*m38*0.1

nodelay

--

true

0

false

Go back
1070.0, 409.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c82 : 1
stoichiometry:c87 : 1

m183*m36*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6

Go back
806.0, 605.0
25.0, 25.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e37

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c89 : 1

m1573*m38*0.1

nodelay

--

true

0

false

PMID: 16419614 TIRAP/Mal forms dimers with MyD88 followed by association with IRAK and activation of NF-kappaB (Fig. 1).

Go back
755.0, 650.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e36

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m39*m37*0.1

nodelay

--

true

0

false

PMID: 16419614 TIRAP/Mal forms dimers with MyD88 followed by association with IRAK and activation of NF-kappaB (Fig. 1).

Go back
751.0, 745.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000215 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1

m186*m40*0.1

nodelay

--

true

0

false

PMID: 16419614 TIRAP/Mal forms dimers with MyD88 followed by association with IRAK and activation of NF-kappaB (Fig. 1).

Go back
751.0, 837.0
25.0, 25.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 MO000000058

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m41*m22*0.1

nodelay

--

true

0

false

PMID: 16419614 TIRAP/Mal forms dimers with MyD88 followed by association with IRAK and activation of NF-kappaB (Fig. 1).

Go back
203.0, 298.0
23.0, 23.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e45 e41

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m46*m42*0.1

nodelay

--

true

0

false

PMID: 16419614, 12447441 Further data suggest that TIRAP/Mal is not specific to TLR4 signalling and that it takes part in the TLR2 signalling as well; however, it does not participate in the MyD88- independent pathway (Yamamoto et al., 2002).

Go back
203.0, 342.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022528 e44

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m6810*m45*0.1

nodelay

--

true

0

false

PMID: 16419614, 12447441 Further data suggest that TIRAP/Mal is not specific to TLR4 signalling and that it takes part in the TLR2 signalling as well; however, it does not participate in the MyD88- independent pathway (Yamamoto et al., 2002).

Go back
318.0, 341.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000016573

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c106 : 1
stoichiometry:c108 : 1

m44*m1572*0.1

nodelay

--

true

0

false

PMID: 16419614, 12447441 Further data suggest that TIRAP/Mal is not specific to TLR4 signalling and that it takes part in the TLR2 signalling as well; however, it does not parti

Go back
1024.0, 298.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m1572*m11*0.1

nodelay

--

true

0

false

PMID: 16419614 Hence, in LPS signalling, the TLR4 recruits two types of adaptors, TIRAP and TRAM, to its cytoplasmic domain that are indirectly connected to two effec-tive adaptors, MyD88 and TRIF, respectively.

Go back
315.0, 394.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 MO000039097

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m47*m17273*0.1

nodelay

--

true

0

false

PMID: 16419614 The inhibition of NF-kappaB activation in response to IL-1, as well as TLR2 and TLR4 ligands (Fig. 1), is mediated through the ability of Tollip to suppress the activity of IRAK.

Go back
314.0, 445.0
25.0, 25.0

p41

p41

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
314.0, 501.0
25.0, 25.0

p42

p42

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e48

e49 MO000019406

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 16419614, 10854325 Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (Burns et al., 2000).

Go back
316.0, 555.0
21.0, 21.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000000212

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m63*m183*0.1

nodelay

--

true

0

false

PMID: 16419614 This, similarly to MyD88, contains DD and upon recruitment to MyD88 via DD-domain interactions is phosphorylated and subsequently associated with TRAF-6.

Go back
694.0, 605.0
25.0, 25.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e42

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m1573*m43*0.1

nodelay

--

true

0

false

PMID: 16419614 The inhibition of NF-kappaB activation in response to IL-1, as well as TLR2 and TLR4 ligands (Fig. 1), is mediated through the ability of Tollip to suppress the activity of IRAK.

Go back
500.0, 155.0
21.0, 21.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16419614, 11607032 Similarly to LPS, the dsRNA stimulation of TLR3 in the MyD88- deficient cells induced activation of NF-kappaB, but no production of inflammatory cytokines (Alexopoulou et al.,2001).

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518.0, 309.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m18998*m64*0.1

nodelay

--

true

0

false

PMID: 16419614, 12539043, 14519765 Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TRIF/TICAM-1.

Go back
438.0, 321.0
25.0, 25.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e16

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c131 : 1

m18998*m16*0.1

nodelay

--

true

0

false

PMID: 16419614 TRIF physically associates with TLR3 and IRF-3 in response to poly(I:C).

Go back
423.0, 366.0
23.0, 23.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000007694

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m66*m977*0.1

nodelay

--

true

0

false

PMID: 16419614 TRIF physically associates with TLR3 and IRF-3 in response to poly(I:C).

Go back
583.0, 402.0
23.0, 23.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000000212

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c137 : 1
stoichiometry:c136 : 1

m65*m183*0.1

nodelay

--

true

0

false

PMID: 16419614 In these experiments, TRIF was found to recruit TRAF-6 to TLR3 through its TRAF6-binding site.

Go back
438.0, 161.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000019398

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m15*m3965*0.1

nodelay

--

true

0

false

PMID: 16419614 NK cells are major players in the antiviral immune response and express TLR3 and are activated directly in response to poly(I:C).

Go back
731.0, 890.0
23.0, 23.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e67

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1

m22*m68*0.1

nodelay

--

true

0

false

PMID: 16419614, 14982987 Furthermore, mutation of the TRAF6-binding site of TRIF only abolished its ability to activate NF-kappaB but not IRF3, suggesting that TLR3-mediated activation of NF-kappaB and IRF3 might bifurcate at TRIF (Jiang et al., 2004).

Go back
477.0, 628.0
27.0, 27.0

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e67 MO000019331 MO000016608

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c142 : 1

m977*m68*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16419614 Recently, two IKK-related kinases, inducible IkappaB kinase (IKK-i) and TANK-binding kinase 1 (TBK1), were suggested to act as IRF-3 kinases and to be involved in IFN-beta production in TLR signalling and viral infection (Fig. 1, Fig. 2b). PMID: 16419614 Thus, viral infection or dsRNA stimulation via TLR3 as well as LPS stimulation via TLR4 induces phosphorylation and subsequent activation of IRF-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene expression.

Go back
477.0, 676.0
27.0, 27.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e30 MO000019331 MO000016608

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c146 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c144 : 1

m977*m31*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 16419614 Restricted to the TLR4 pathway, TRAM activates IRF-3, IRF-7, and NF-kappaB-dependent signalling pathways in MyD88-independent manner (Figs. 1, 2a). PMID: 16419614 Recently, two IKK-related kinases, inducible IkappaB kinase (IKK-i) and TANK-binding kinase 1 (TBK1), were suggested to act as IRF-3 kinases and to be involved in IFN-beta production in TLR signalling and viral infection (Fig. 1, Fig. 2b). PMID: 16419614 Thus, viral infection or dsRNA stimulation via TLR3 as well as LPS stimulation via TLR4 induces phosphorylation and subsequent activation of IRF-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene expression.

Go back
723.0, 862.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e30

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m22*m31*0.1

nodelay

--

true

0

false

PMID: 16419614 Restricted to the TLR4 pathway, TRAM activates IRF-3, IRF-7, and NF-kappaB-dependent signalling pathways in MyD88-independent manner (Figs. 1, 2a).

Go back
579.0, 730.0
23.0, 23.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e30

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m980*m31*0.1

nodelay

--

true

0

false

PMID: 16419614 Restricted to the TLR4 pathway, TRAM activates IRF-3, IRF-7, and NF-kappaB-dependent signalling pathways in MyD88-independent manner (Figs. 1, 2a).

Go back
471.0, 1023.0
25.0, 25.0

p55

p55

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 16419614 Thus, viral infection or dsRNA stimulation via TLR3 as well as LPS stimulation via TLR4 induces phosphorylation and subsequent activation of IRF-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene expression.

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448.0, 1292.0
23.0, 23.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e103

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c159 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 16419614 Thus, viral infection or dsRNA stimulation via TLR3 as well as LPS stimulation via TLR4 induces phosphorylation and subsequent activation of IRF-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene expression. PMID: 16419614 Activated by TLR3 and TLR4, IRF-3 binds the interferon-sensitive response element (ISRE) in DNA and induces expression of the IFN-beta gene.

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468.0, 1248.0
23.0, 23.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e69 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m70*m71*0.1

nodelay

--

true

0

false

PMID: 16419614 Activated by TLR3 and TLR4, IRF-3 binds the interferon-sensitive response element (ISRE) in DNA and induces expression of the IFN-beta gene.

Go back
488.0, 1196.0
23.0, 23.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 16419614, 11790540, 15800576 IRF-7 is also induced by viral infection and is critically involved in the system of IFN-alpha/beta gene induction (Taniguchi et al., 2002, Honda et al., 2005).

Go back
511.0, 1167.0
25.0, 25.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e68

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 16419614, 11790540, 15800576 IRF-7 is also induced by viral infection and is critically involved in the system of IFN-alpha/beta gene induction (Taniguchi et al., 2002, Honda et al., 2005).

Go back
134.0, 1069.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022185 MO000019399

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 16419614, 11489966 Accordingly, TLR5, the receptor for flagellin, is exclusively expressed on the basolateral, but not the apical surface of the intestinal epithelial cells (Gewirtz et al., 2001).

Go back
123.0, 674.0
23.0, 23.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e46 MO000000166 MO000000030

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c170 : 1

m47*m146*m74*0.1

nodelay

--

true

0

false

PMID: 16419614 In the TLR2-mediated signalling, stimulation of human monocytes by S. aureus induces a fast and transient activation of the Rho GTPases Rac1 and Cdc42 followed by the recruitment of active Rac1 and phosphatidylinositol-3 kinase (PI3K) to the TLR2 cytosolic domain.

Go back
317.0, 932.0
27.0, 27.0

p61

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e75 MO000000193

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m78*m166*0.1

nodelay

--

true

0

false

PMID: 16419614, 11101877 This in turn activates Akt kinase that induces activation and translocation of the p65 subunit of NF-kappaB into the cell nucleus in a process that is independent of IkappaB degradation.

Go back
309.0, 872.0
27.0, 27.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e73

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c174 : 1
stoichiometry:c173 : 1

m77*m75*0.1

nodelay

--

true

0

false

PMID: 16419614, 11101877 This in turn activates Akt kinase that induces activation and translocation of the p65 subunit of NF-kappaB into the cell nucleus in a process that is independent of IkappaB degradation.

Go back
372.0, 1280.0
23.0, 23.0

p63

p63

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e74

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 16419614, 11101877 This in turn activates Akt kinase that induces activation and translocation of the p65 subunit of NF-kappaB into the cell nucleus in a process that is independent of IkappaB degradation.

Go back
619.0, 1667.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m19828*m80*0.1

nodelay

--

true

0

false

PMID: 16419614 NK cells also seem to be able to respond directly to other viral TLR stimuli, such as CpG DNA.

Go back
583.0, 1667.0
25.0, 25.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m1572*m81*0.1

nodelay

--

true

0

false

PMID: 16419614 However, all these effects are MyD88-dependent.

Go back
508.0, 1536.0
23.0, 23.0

p66

p66

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e79

MO000016922

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16419614 Similar to the LPS response, TLR9 signalling can also induce expression of IFN-beta and IFN-inducible genes, and upregulation of CD40.

Go back
580.0, 1336.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e79

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c186 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16419614 Similar to the LPS response, TLR9 signalling can also induce expression of IFN-beta and IFN-inducible genes, and upregulation of CD40.

Go back
589.0, 1500.0
19.0, 19.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16419614 Similar to the LPS response, TLR9 signalling can also induce expression of IFN-beta and IFN-inducible genes, and upregulation of CD40.

Go back
610.0, 917.0
25.0, 25.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e64

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c199 : 1
stoichiometry:c195 : 1

m85*m65*0.1

nodelay

--

true

0

false

PMID: 16419614, 10626894 Not just a bacterial, but also a viral infection or dsRNA induce JNK kinase, leading to stimulation of AP-1 (Chu et al., 1999).

Go back
841.0, 1253.0
21.0, 21.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289

G010962

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c19 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 16419614 Renal inflammation evoked by ischaemia markedly enhanced synthesis of TLR2 and TLR4 mRNA followed by significant elevation of protein expression in the distal tubular epithelium, the thin limb of Henle¡Çs loop and collecting ducts. This phenomenon was shown to be completely dependent on the action of IFN-gamma and TNF. PMID: 16419614 Preincubation with TNF or IFN-gamma significantly induces endothelial TLR2 expression.

Go back
607.0, 962.0
24.0, 24.0

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e46

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c200 : 1
stoichiometry:c197 : 1

m85*m47*0.1

nodelay

--

true

0

false

PMID: 16419614, 1744583, 10318814 TLR4 ligand LPS and various TLR2 ligands rapidly activated JNK kinases, which was followed by activation of the AP-1 transcription factor (Mackman et al., 1991; Gupta et al., 1999).

Go back
742.0, 917.0
26.0, 26.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e37

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c198 : 1
stoichiometry:c193 : 1

m85*m38*0.1

nodelay

--

true

0

false

PMID: 16419614, 7622446 The activation of the AP-1 is induced through phosphorylation by the MAP kinases such as JNK and ERK, respectively, that are activated by means of TLR or IL-1R engagement (Karin, 1995).

Go back
686.0, 1025.0
25.0, 25.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c203 : 1
stoichiometry:c202 : 1

m87*m86*0.1

nodelay

--

true

0

false

PMID: 16419614, 7622446 The activation of the AP-1 is induced through phosphorylation by the MAP kinases such as JNK and ERK, respectively, that are activated by means of TLR or IL-1R engagement (Karin, 1995).

Go back
767.0, 978.0
23.0, 23.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000023

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m26*m85*0.1

nodelay

--

true

0

false

PMID: 16419614, 7622446 The activation of the AP-1 is induced through phosphorylation by the MAP kinases such as JNK and ERK, respectively, that are activated by means of TLR or IL-1R engagement (Karin, 1995).

Go back
778.0, 945.0
25.0, 25.0

p74

p74

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000000023

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m25*m85*0.1

nodelay

--

true

0

false

PMID: 16419614, 7622446 The activation of the AP-1 is induced through phosphorylation by the MAP kinases such as JNK and ERK, respectively, that are activated by means of TLR or IL-1R engagement (Karin, 1995).

Go back
1063.0, 1235.0
25.0, 25.0

p75

p75

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e84

MO000021062

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c211 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 16419614, 12829592 The agonists of all TLRs expressed in neutrophils triggered cytokine release, superoxide generation, L-selectin shedding and increased phagocytosis of opsonised latex beads (Hayashi et al., 2003).

Go back
447.0, 1383.0
25.0, 25.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e87 e88 e89

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c212 : 1

m92*m93*m94*0.1

nodelay

--

true

0

false

PMID: 16419614, 15995707 Indeed, recently it was found that agonists of TLR3 and TLR4 had acted in synergy with agonists of TLR8 in inducing IL-12, IL-23 and Delta-4 in amounts that were 50- to 100-fold higher than those induced by optimal concentrations of single agonists leading to enhanced and sustained TH1- polarizing capacity (Napolitani et al., 2005).

Go back
468.0, 1420.0
23.0, 23.0

p77

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e87 e88 e89

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c213 : 1

m92*m93*m94*0.1

nodelay

--

true

0

false

PMID: 16419614, 15995707 Indeed, recently it was found that agonists of TLR3 and TLR4 had acted in synergy with agonists of TLR8 in inducing IL-12, IL-23 and Delta-4 in amounts that were 50- to 100-fold higher than those induced by optimal concentrations of single agonists leading to enhanced and sustained TH1- polarizing capacity (Napolitani et al., 2005).

Go back
496.0, 1456.0
23.0, 23.0

p78

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e87 e88 e89

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c214 : 1

m92*m93*m94*0.1

nodelay

--

true

0

false

PMID: 16419614, 15995707 Indeed, recently it was found that agonists of TLR3 and TLR4 had acted in synergy with agonists of TLR8 in inducing IL-12, IL-23 and Delta-4 in amounts that were 50- to 100-fold higher than those induced by optimal concentrations of single agonists leading to enhanced and sustained TH1- polarizing capacity (Napolitani et al., 2005).

Go back
768.0, 1155.0
21.0, 21.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 16419614 Initially, NF-kappaB (nuclear factorkappa B) was found to be essential for the transcription of immunoglobulin light chain genes in B cells.

Go back
845.0, 1285.0
21.0, 21.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010962

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c20 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 16419614 Renal inflammation evoked by ischaemia markedly enhanced synthesis of TLR2 and TLR4 mRNA followed by significant elevation of protein expression in the distal tubular epithelium, the thin limb of Henle¡Çs loop and collecting ducts. This phenomenon was shown to be completely dependent on the action of IFN-gamma and TNF. PMID: 16419614 Preincubation with TNF or IFN-gamma significantly induces endothelial TLR2 expression.

Go back
670.0, 1206.0
20.0, 20.0

p80

p80

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e91 e95

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c231 : 1
stoichiometry:c230 : 1

m96*m100*0.1

nodelay

--

true

0

false

PMID: 16419614, 2112087 Interestingly, NF-IL6 was shown to bind to regulatory regions of various acute-phase protein and several other cytokine genes such as TNF, IL-8 and G-CSF, implying that NF-IL6 has a role in the regulation ot only of the IL-6 gene, but also of several other genes involved in acute-phase reaction, inflammation and haematopoiesis (Akira et al., 1990).

Go back
650.0, 1161.0
25.0, 25.0

p81

p81

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e92 e91

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1
stoichiometry:c228 : 1

m97*m96*0.1

nodelay

--

true

0

false

PMID: 16419614 NF-IL6 (nuclear factor-IL6) specifically binds to an IL-1-responsive element in the IL-6 gene.

Go back
820.0, 1408.0
23.0, 23.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000214

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c236 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 16419614 The NF-IL6 mRNA was induced by the stimulation with LPS, IL-1 or IL-6.

Go back
805.0, 1437.0
22.0, 22.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007384

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c237 : 1

m871*0.1

nodelay

--

true

0

false

PMID: 16419614 The NF-IL6 mRNA was induced by the stimulation with LPS, IL-1 or IL-6.

Go back
836.0, 1380.0
23.0, 23.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 16419614 The NF-IL6 mRNA was induced by the stimulation with LPS, IL-1 or IL-6.

Go back
668.0, 1252.0
23.0, 23.0

p85

p85

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e97 e91

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c243 : 1

m102*m96*0.1

nodelay

--

true

0

false

PMID: 16419614, 2112087 Interestingly, NF-IL6 was shown to bind to regulatory regions of various acute-phase protein and several other cytokine genes such as TNF, IL-8 and G-CSF, implying that NF-IL6 has a role in the regulation ot only of the IL-6 gene, but also of several other genes involved in acute-phase reaction, inflammation and haematopoiesis (Akira et al., 1990).

Go back
649.0, 1281.0
21.0, 21.0

p86

p86

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e98 e91

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m103*m96*0.1

nodelay

--

true

0

false

PMID: 16419614, 2112087 Interestingly, NF-IL6 was shown to bind to regulatory regions of various acute-phase protein and several other cytokine genes such as TNF, IL-8 and G-CSF, implying that NF-IL6 has a role in the regulation ot only of the IL-6 gene, but also of several other genes involved in acute-phase reaction, inflammation and haematopoiesis (Akira et al., 1990).

Go back
1072.0, 1454.0
23.0, 23.0

p87

p87

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016882 MO000016894

MO000000342

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1

m155666*m1812*0.1

nodelay

--

true

0

false

PMID: 16419614, 8336793 LPS or inflammatory cytokine stimulation of macrophages and hepatocytes activated MAP kinases that in turn phosphorylated NF-IL6, enhancing its transcriptional efficacy (Trautwein et al., 1993).

Go back
607.0, 1166.0
23.0, 23.0

p88

p88

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e101 MO000000342

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c249 : 1
stoichiometry:c248 : 1

m106*m273*0.1

nodelay

--

true

0

false

PMID: 16419614, 8336793 LPS or inflammatory cytokine stimulation of macrophages and hepatocytes activated MAP kinases that in turn phosphorylated NF-IL6, enhancing its transcriptional efficacy (Trautwein et al., 1993).

Go back
602.0, 1366.0
19.0, 19.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e100

G010291

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 16419614, 7530603 The NF-IL6 deficient mice were highly susceptible to infection with Listeria monocytogenes; moreover NF-IL6 was essential for the induction of G-CSF in macrophages.

Go back
848.0, 1316.0
23.0, 23.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c21 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 16419614 Renal inflammation evoked by ischaemia markedly enhanced synthesis of TLR2 and TLR4 mRNA followed by significant elevation of protein expression in the distal tubular epithelium, the thin limb of Henle¡Çs loop and collecting ducts. This phenomenon was shown to be completely dependent on the action of IFN-gamma and TNF.

Go back
525.0, 1225.0
21.0, 21.0

p90

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e91 MO000016882

G029941

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c256 : 1
stoichiometry:c254 : 1

m96*m155666*0.1

nodelay

--

true

0

false

PMID: 16419614, 12023384 NF-IL6-deficient murine macrophages in stimulation with LPS displayed impaired expression of membrane-bound glutathione-dependent PGE2 synthase or Cox-2.

Go back
569.0, 1253.0
21.0, 21.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e91 MO000016882

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c257 : 1
stoichiometry:c255 : 1

m96*m155666*0.1

nodelay

--

true

0

false

PMID: 16419614, 12023384 NF-IL6-deficient murine macrophages in stimulation with LPS displayed impaired expression of membrane-bound glutathione-dependent PGE2 synthase or Cox-2.

Go back
462.0, 1346.0
19.0, 19.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e71 e76

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c260 : 1
stoichiometry:c259 : 1

m72*m79*0.1

nodelay

--

true

0

false

PMID: 16419614, 14557267 The results therefore indicate that IRF-3-mediated activation of the ISRE by TLR4 requires the p65 subunit of NF-kappaB.

Go back
684.0, 1544.0
23.0, 23.0

p93

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016656 MO000016882

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c279 : 1
stoichiometry:c271 : 1

m1633*m155666*0.1

nodelay

--

true

0

false

PMID: 16419614 IL-1 and LPS stimulation induce activation of the STAT family of transcription factors, which consists of seven members.

Go back
732.0, 1488.0
23.0, 23.0

p94

p94

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 MO000016882 MO000016660

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c263 : 1
stoichiometry:c277 : 1
stoichiometry:c262 : 1

m1357*m155666*m1636*0.1

nodelay

--

true

0

false

PMID: 16419614, 9649436 Bacterial infection of macrophages or treatment with LPS resulted in rapid STAT1 serine phosphorylation, independent of concomitant tyrosine phosphorylation. PMID: 16419614, 9794412 Other studies proved that LPS stimulation of macrophages using the MyD88-independent pathway and IRF-3-induced expression of IFN-beta, which then induced expression of IFN-regulated genes through activation of STAT1.

Go back
770.0, 1410.0
19.0, 19.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000019704

G010384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 16419614, 12356687 LPS-induced expression of IRF-1, iNOS and IFN-inducible genes such as IP-10 was severely impaired in STAT1-deficient murine macrophages, suggesting that STAT1 may play a role in the response to LPS.

Go back
734.0, 1426.0
19.0, 19.0

p96

p96

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

MO000019704

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c267 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 16419614, 12356687 LPS-induced expression of IRF-1, iNOS and IFN-inducible genes such as IP-10 was severely impaired in STAT1-deficient murine macrophages, suggesting that STAT1 may play a role in the response to LPS.

Go back
718.0, 1458.0
19.0, 19.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000019704

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c268 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 16419614, 12356687 LPS-induced expression of IRF-1, iNOS and IFN-inducible genes such as IP-10 was severely impaired in STAT1-deficient murine macrophages, suggesting that STAT1 may play a role in the response to LPS.

Go back
724.0, 1544.0
23.0, 23.0

p98

p98

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016656 MO000000214

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c278 : 1
stoichiometry:c273 : 1

m1633*m185*0.1

nodelay

--

true

0

false

PMID: 16419614 IL-1 and LPS stimulation induce activation of the STAT family of transcription factors, which consists of seven members.

Go back
350.0, 1350.0
27.0, 27.0

p99

p99

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1

m93217*0.1

nodelay

--

true

0

false

--

Go back
1268.0, 530.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.0, 326.62551505486397

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.0, 310.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
114.80299013432949, 89.98594225952871

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.0, 310.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 276.2771337008357

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.12147519731585, 282.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 354.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.94016726065047, 355.97659811227254

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.0, 354.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.3812746502559, 364.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 406.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 277.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.83515762797066, 409.6156438174465

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.2300312726663, 416.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 458.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.1321638494413, 469.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 514.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.2469504755442, 525.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 516.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 566.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.1601724872445, 575.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.9999990662484, 566.0038652328467

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 271.8415826524321

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 618.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 623.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 618.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.0, 138.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 183.78349240575648

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 176.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.9874520661698, 335.44789450838334

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.9427023841746, 323.9557608678052

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 248.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 285.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.0, 132.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 274.35316024014446

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.4376015698018, 267.6564023547028

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 261.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 397.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.77715324278927, 282.41707152016465

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.0, 267.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 264.874411670338

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.5227629812609, 426.6317991202439

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.3612370850286, 857.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 902.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.78549223682904, 193.49940217607812

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 257.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.0, 642.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.1256389183169, 654.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.0, 653.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 690.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.535956680553, 257.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.4098448248975, 287.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.952573534035, 634.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.2494651199621, 651.383083722649

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.7839864320407, 642.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 186.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.0, 690.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.8647177581715, 853.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 876.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.4722186639715, 287.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 742.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.5857022873224, 751.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.8219460844558, 287.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.0, 707.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.97811356708, 1048.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 1304.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 1036.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 1213.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 1235.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.81326653363635, 1268.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.3260780821423, 1466.2757958046864

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
501.65940268685006, 797.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
501.0, 1219.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.2377328001627, 797.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 1161.506694597132

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
144.3281660908139, 427.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.61366894208442, 692.456022239382

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
166.2184305268028, 1033.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
146.0, 686.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
153.1002737405048, 695.6859344554533

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.89723312160595, 852.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 886.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 717.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.4652570302059, 901.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.0, 946.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 956.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 999.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 1303.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 1082.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 1596.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 1700.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.3738459977246, 1631.2537688951081

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0231296564598, 428.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.2235169765557, 1644.0592796928047

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.0, 1624.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.1318814801737, 1314.6243987850064

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 1548.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.5298221281347, 1566.5894663844042

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.0, 1366.8792621167072

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.2636750760037, 1269.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 1526.1372572652417

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.8089875327071, 1483.4906334205523

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 930.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.5709597253864, 939.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 930.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 938.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.7075489304051, 940.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 974.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.9814725020518, 442.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
565.0, 267.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.0, 530.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.929823205461, 1291.0573097607282

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.54690437104583, 406.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.0, 1038.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.0, 1038.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 989.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.0, 1043.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1095.5894663844042, 1185.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
702.0, 934.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.8911513906571, 960.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 940.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.8730161395608, 978.419724221888

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
829.795129565557, 1331.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.9302229814525, 1181.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1040.982281262853, 1249.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 1396.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.0, 1432.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.0, 1475.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 1398.9956818259122

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 1400.8832601460708

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 1403.7152492559105

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
160.0, 1432.1038873433156

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 1433.998580240028

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.4087388781563, 1348.0183750985082

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.0, 1436.8462176857674

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
160.0, 1438.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 1468.1419894645753

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 1469.9807805078372

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.4335579758164, 917.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.0, 1176.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.079787787583, 1135.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 1192.2273043158027

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 1170.8834522085988

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 1219.79887605359

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.9755070225004, 1297.625529962549

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
690.0, 1225.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.6965114603821, 1221.1825928021979

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 1505.2987830845307

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.999999986371, 875.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.9997657631114, 121.503799321972

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.9195959492894, 1388.1313708498985

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.6568542494924, 1400.6568542494924

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.365469824569, 1402.6422871255309

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.5610156344095, 1276.5774527681926

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 1237.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.999870870895, 1326.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.2445359345026, 1309.6786755654036

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 1242.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.1808595010745, 1302.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 1275.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
895.0, 105.52236861531549

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1090.4256292582156, 1484.623406240106

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.998068565882, 1466.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 1144.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 1189.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.1627075391262, 1085.7939623006419

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.9999999902188, 1263.9781198922442

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.4984801712583, 1341.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.0, 1385.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.9822812628529, 1231.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.020613557655, 1242.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 1246.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.0, 1274.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
91.02563777910893, 57.53515481485715

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
68.20485451979619, 24.026204928408845

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 1301.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.0, 1353.315191898443

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.9999997629917, 1331.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
441.0, 1356.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.8185818291893, 1315.1841297588207

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.0, 1484.2108369169305

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.9999979424916, 88.2615559914646

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.1676940130167, 1448.0950515759703

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.2738595105969, 1436.897928965701

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.2179589656599, 1400.0335858293438

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.6405130944898, 1426.3711937189796

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 1468.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.9895013078127, 1469.4097180157853

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1174.0, 874.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
643.0, 1529.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.6499055497528, 1529.509867769654

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 1527.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.8228104326101, 1523.1772308771083

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.373530167219, 786.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.36323363611695, 1310.0

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.0518397602303, 1371.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 1394.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.009697636713, 888.0

c278

c278

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
696.0046220224009, 67.53233668273424

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1182.9855816161194, 881.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1085.1117964514128, 1087.6636527173944

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1252.0, 874.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.2061494509512, 536.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 441.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1109.6781814332587, 580.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 618.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 441.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1113.440446698827, 925.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.0, 962.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.0, 535.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 670.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1109.5003060050374, 629.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.0, 538.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 137.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.8173698057533, 972.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 1014.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 664.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 663.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1115.0, 818.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1077.0, 1089.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 681.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 722.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 1025.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.0, 1070.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 193.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.0, 850.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.1601724872445, 861.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 862.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
887.0, 902.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.9649651253947, 829.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
940.7488790638827, 921.0672417366595

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.0, 1089.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0, 1078.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 1226.0529789706945

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 1229.3134845335628

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.0, 185.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
797.1594239132406, 999.5696847522601

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.5652845192106, 834.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.4829175920399, 276.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 322.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.5455257366611, 274.58317520481955

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.0459984420344, 198.39742478779772

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.0, 198.99981739120508

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.5726594108631, 191.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1178.0, 1082.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 1126.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.0, 176.57956534040258

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 732.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 774.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.0, 265.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 256.10251176948293

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 332.1348246177936

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 257.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.0, 310.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1180.0, 321.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.0, 362.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.41057699107, 375.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 177.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1002.4821534597512, 635.2024028825624

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.3597617283293, 633.9391038225928

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.4435011210878, 374.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.0, 817.0447410007557

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.1019289522081, 814.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.2115175844426, 445.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 440.60566485531353

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1095.0, 422.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 618.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 630.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 169.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.9294846883888, 431.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.2613881364466, 670.3574160200775

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.0, 673.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 662.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 758.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 765.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.4437601569801, 727.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.7839864320407, 812.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 850.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 856.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back