1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16713969.csml convertedTime:2009.07.01.10:55

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Parallel pathways of virus recognition.
Authors Tenoever BR, Maniatis T.
Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge,Massachusetts 02138, USA.
Abstract Viruses trigger signaling pathways of innate immunity. In this issue, it isshown that the mitochondrial antiviral signaling protein is critical forintracellular detection signaling, but is dispensable for the activation ofinnate immunity via Toll-like receptors.
PMID 16713969
Model Abstract

Entity

G010228:IFN-beta MO000000023:JNK MO000000210:IKK-alpha:IKK-beta:IKK-gamma MO000000212:TRAF6 MO000007694:IRF-3:IRF-7 MO000016573:MyD88 MO000016632:p50:RelA-p65 MO000016660:IFNbeta MO000016963:TRAF3 MO000019331:TBK1 MO000019398:TLR3 MO000041125:TRIF MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11: e12:Viral PAMPs e13:Viral PAMPs:TLR3 e14:Viral PAMPs:TLR3:TRIF e15:Viral PAMPs:TLR3:TRIF:TRAF3 e16:Viral PAMPs:TLR3:TRIF:TRAF6 e17:TBK1{active} e18:IKK-alpha:IKK-beta:IKK-gamma{active} e19:Viral PAMPs e2: e20:Viral PAMPs:DDX58 e21:Viral PAMPs:IFIH1 e22:Viral PAMPs:DDX58:MAVS e23:Viral PAMPs:IFIH1:MAVS e24:Viral PAMPs:IFIH1:MAVS:TRAF3 e25:Viral PAMPs:DDX58:MAVS:TRAF3 e26:JNK{active} e27:Viral PAMPs:TLR7 e28:Viral PAMPs:TLR9 e29:Viral PAMPs:TLR7:MyD88 e3: e30:Viral PAMPs:TLR9:MyD88 e31:Viral PAMPs:TLR7:MyD88:TRAF3:TRAF6 e32:Viral PAMPs:TLR9:MyD88:TRAF3:TRAF6 e33:ATF-2:C-Jun e34:ATF-2:C-Jun{active} e35:IRF-3:IRF-7{active} e36:p50:RelA-p65{active} e37:IRAK1:IKK-alpha e38:IRAK1:IKK-alpha{active} e39:IRF-7:IRF-7 e4: e40:IRF-7:IRF-7{active} e41:ATF-2:C-Jun{active} e42:IRF-3:IRF-7{active} e43:p50:RelA-p65{active} e44:IRF-7:IRF-7{active} e45:IFN-beta e46:IFN-beta:(ATF2:C-Jun):(IRF-3:IRF-7):(p50:RelA-p65):(IRF-7:IRF-7){active} e47: e48: e49: e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63: e64: e65: e66: e67: e68: e69: e7: e70: e71: e72: e73: e74: e75: e76: e77: e78:JAK e79:JAK{active} e8: e80:STAT e81:STAT{active} e82:ISGs e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p5 p6 p7 p8 p9
Model Detail
662.0, 1246.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36

p37

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
475.0, 779.0
18.0, 18.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p14

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
536.0, 296.0
40.0, 40.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p17 p18

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
451.0, 243.0
18.0, 18.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p23 p24

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
576.0, 872.0
24.0, 24.0

IRF-3:IRF-7

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
779.0, 171.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
857.0, 709.0
22.0, 22.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
130.0, 1250.0
20.0, 20.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p38

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
312.0, 280.0
16.0, 16.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p11 p12 p23 p24

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
334.0, 478.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p15 p16

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
535.0, 135.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
523.0, 207.0
18.0, 18.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
956.0, 388.0
16.0, 16.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
847.0, 267.0
18.0, 18.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
334.0, 546.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
470.0, 566.0
19.0, 19.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
403.0, 787.0
18.0, 18.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
226.8480892812051, 106.41771052268953
873.1518614602078, 1267.816502840221

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
77.74541483775374, 1456.0516254929548
408.30504716414, 618.4485025894742

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
812.0, 251.0
216.55225380691382, 361.5321525420512

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
622.0, 51.5
28.30348158583215, 17.453813644596494

Viral PAMPs

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
463.5, 123.0
17.977417233062923, 34.79500109625082

Viral PAMPs:TLR3

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
337.5, 126.0
20.580657001284642, 28.717195815746017

Viral PAMPs:TLR3:TRIF

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3 p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
250.0, 240.0
19.147058823529417, 31.911764705882355

Viral PAMPs:TLR3:TRIF:TRAF3

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
254.0, 412.0
19.147058823529417, 31.911764705882355

Viral PAMPs:TLR3:TRIF:TRAF6

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
466.0, 442.0
20.0, 20.0

TBK1{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p15 p16

p30

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
540.0, 360.0
40.0, 40.0

IKK-alpha:IKK-beta:IKK-gamma{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p17 p18

p25

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
330.0, 611.5
28.30348158583215, 17.453813644596494

Viral PAMPs

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p8 p19 p20

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
226.8480892812051, 106.41771052268953
873.1518614602078, 1267.816502840221

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
442.5, 604.0
19.27012164639227, 23.596067322112983

Viral PAMPs:DDX58

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
466.5, 660.0
19.6375604065989, 24.0459923346109

Viral PAMPs:IFIH1

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p10

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
652.5, 624.0
22.54560469810975, 31.45898329968801

Viral PAMPs:DDX58:MAVS

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p12

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
484.5, 740.0
22.54560469810975, 31.45898329968801

Viral PAMPs:IFIH1:MAVS

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10 p12

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
310.0, 828.0
19.676470588235297, 32.79411764705882

Viral PAMPs:IFIH1:MAVS:TRAF3

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p13 p16 p18

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
638.0, 716.0
19.676470588235297, 32.79411764705882

Viral PAMPs:DDX58:MAVS:TRAF3

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p14 p15 p17

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
463.0, 906.0
19.0, 19.0

JNK{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13 p14

p29

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
934.5, 318.0
18.14733611050208, 35.12387634290726

Viral PAMPs:TLR7

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p19

p21

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
962.5, 426.0
18.14733611050208, 35.12387634290726

Viral PAMPs:TLR9

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

p22

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
852.5, 520.0
22.782345384474223, 31.789319141126825

Viral PAMPs:TLR7:MyD88

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p23

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
244.31112651040925, 123.88074775189376
838.2257870017996, 1232.8904283818133

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
864.5, 560.0
22.782345384474223, 31.789319141126825

Viral PAMPs:TLR9:MyD88

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p24

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
834.0, 363.0
20.823529411764703, 34.70588235294118

Viral PAMPs:TLR7:MyD88:TRAF3:TRAF6

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p26

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
830.0, 435.0
20.823529411764703, 34.70588235294118

Viral PAMPs:TLR9:MyD88:TRAF3:TRAF6

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p27

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
294.5, 972.0
18.95167472087985, 23.206132311281454

ATF-2:C-Jun

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
398.5, 1032.0
18.95167472087985, 23.206132311281454

ATF-2:C-Jun{active}

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
688.0, 840.0
24.0, 24.0

IRF-3:IRF-7{active}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p32

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
773.0, 813.0
22.0, 22.0

p50:RelA-p65{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p33

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
663.5, 230.0
16.820529911681383, 20.596567238793533

IRAK1:IKK-alpha

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p26 p27

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
887.5, 650.0
16.820529911681383, 20.596567238793533

IRAK1:IKK-alpha{active}

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26 p27

p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
812.0, 764.0
24.0, 24.0

IRF-7:IRF-7

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
276.61774538443694, 154.4410629030008
773.6125492537443, 1171.7697980795988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
912.0, 820.0
24.0, 24.0

IRF-7:IRF-7{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p34

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
566.5, 1084.0
18.95167472087985, 23.206132311281454

ATF-2:C-Jun{active}

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31 p36

p35

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
640.0, 1016.0
24.0, 24.0

IRF-3:IRF-7{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p36

p35

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
769.0, 1009.0
22.0, 22.0

p50:RelA-p65{active}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p36

p35

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
860.0, 1084.0
24.0, 24.0

IRF-7:IRF-7{active}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34 p36

p35

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
634.0, 1193.5
60.0, 13.0

IFN-beta

--

e45

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p35

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
768.7266649524299, 1141.4058884031883
47.179223450758556, 13.36744664438159

IFN-beta:(ATF2:C-Jun):(IRF-3:IRF-7):(p50:RelA-p65):(IRF-7:IRF-7){active}

--

e46

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p35

p36

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
60.69430112999602, 1439.9221936072381
442.4072745796546, 650.7073663609082

--

e47

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
345.9702289304694, 1855.9367338272045
15.656985854603358, 14.17369245785147

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
304.90126768447834, 1921.2737176276453
44.33581043601344, 40.135575763127974

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false true false

--

Go back
812.0, 251.0
210.74992888703446, 351.84522026055765

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
527.9046228162845, 935.5271749435635
416.5761638292004, 377.78881151735675

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
572.897951498023, 944.4802205579807
243.58457251837797, 366.15260582380387

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
533.3348521399427, 940.5695307441034
405.7157051818845, 367.70409991627764

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
534.1105991861792, 941.3452777903401
404.1642110894104, 366.15260582380387

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
527.9046228162845, 935.5271749435635
416.5761638292004, 377.78881151735675

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
527.9046228162845, 935.5271749435635
416.5761638292004, 377.78881151735675

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
531.5622020263502, 943.8936749501686
404.1642110894104, 366.15260582380387

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
831.9974649411388, 1090.6765841909387
26.025389836619205, 23.55982658893951

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
763.7317248722936, 1199.2811706640996
73.69596939250282, 66.71424597637106

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
527.9046228162845, 935.5271749435635
416.5761638292004, 377.78881151735675

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
812.0, 251.0
210.74992888703446, 351.84522026055765

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
626.0892807180883, 1103.4134010872287
13.192355014094783, 6.351874636416014

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
625.6487506421305, 1084.4706078210438
45.15433278567453, 81.27779901421417

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
644.5915439083161, 1137.3342169359807
7.048481215324796, 7.048481215324806

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
172.3721393215216, 1766.958687327546
239.5349951850937, 219.41866772982408

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false true false

--

Go back
163.0266742892352, 1762.59818554086
250.61400214883378, 227.27936507724763

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false true false

--

Go back
190.0948532922749, 1767.9843760809645
146.54152080956024, 220.27897395577182

--

e65

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false true false

--

Go back
166.29352347925698, 1765.6316883601662
244.08030376878986, 221.21235943863536

--

e66

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
163.0266742892352, 1762.59818554086
250.61400214883378, 227.27936507724763

--

e67

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
166.76021622068896, 1766.0983811015985
243.14691828592632, 220.27897395577182

--

e68

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false true false

--

Go back
221.82995970963185, 1852.2031918957503
27.165039760695393, 48.89707156925168

--

e69

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false true false

--

Go back
51.47748290958663, 1430.7053753868283
460.8409110204738, 669.1410028017268

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
222.094984487785, 1863.5992573563342
7.936577209458613, 3.8213149527022963

--

e70

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
233.22602517021667, 1884.0061652741256
4.2403964504500085, 4.240396450450008

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false true false

--

Go back
163.0266742892352, 1762.59818554086
250.61400214883378, 227.27936507724763

--

e72

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false true false

--

Go back
163.0266742892352, 1762.59818554086
250.61400214883378, 227.27936507724763

--

e73

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
59.14686761115891, 1444.7003028190004
433.55273124230735, 629.5185657638294

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
63.45248709274338, 1456.0025539581593
431.57332520560175, 621.2625875169172

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false true false

--

Go back
56.91765299997052, 1441.9328857726148
446.6959644692655, 628.3756179955917

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
57.53226030556476, 1433.3980516798413
451.94135933790113, 640.3892324197561

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
166.0, 1556.5
20.959999999999997, 15.719999999999994

JAK

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
302.0, 1548.5
20.959999999999997, 15.719999999999994

JAK{active}

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
239.60977086795768, 135.80278192036164
848.3697080438203, 1231.832816079627

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
248.5, 1645.0
14.036023344737377, 22.761118937411958

STAT

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
349.5, 1649.0
13.097806399678019, 21.23968605353192

STAT{active}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
314.0, 1888.0
38.09688581314878, 20.31833910034602

ISGs

--

e82

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
51.47748290958663, 1430.7053753868283
460.8409110204738, 669.1410028017268

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
513.0, 49.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000019398

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m3965*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members

Go back
537.0, 665.0
21.0, 21.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000094908

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m21*m68199*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
309.0, 733.0
21.0, 21.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016963

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m23*m1872*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
589.0, 665.0
21.0, 21.0

p9

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016963

e23 e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m22*m1872*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
394.0, 834.0
19.0, 19.0

p5

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m26*m24*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
618.0, 778.0
19.0, 19.0

p5

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000023

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m25*m26*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
718.0, 590.0
19.0, 19.0

p5

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000019331

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m25*m3902*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
382.0, 682.0
19.0, 19.0

p5

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000019331

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m24*m3902*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
658.0, 458.0
19.0, 19.0

p5

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000210

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m25*m181*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
638.0, 382.0
19.0, 19.0

p5

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24 MO000000210

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m24*m181*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
714.0, 234.0
19.0, 19.0

p7

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000042126

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m19*m19940*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members

Go back
462.0, 206.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c4 : 1
stoichiometry:c6 : 1

m18998*m13*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
742.0, 398.0
19.0, 19.0

p7

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000042012

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m19*m19828*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members

Go back
739.0, 327.0
17.0, 17.0

p3

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m1572*m28*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
751.0, 499.0
17.0, 17.0

p3

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000016573

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m29*m1572*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
595.0, 255.0
17.0, 17.0

p3

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000000212 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m1872*m183*m30*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
599.0, 519.0
17.0, 17.0

p3

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000000212 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m1872*m183*m31*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
722.0, 702.0
19.0, 19.0

p5

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e18 MO000016632

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m18*m1617*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
638.0, 342.0
19.0, 19.0

p5

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m32*m38*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
758.0, 614.0
19.0, 19.0

p5

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m33*m38*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
994.0, 714.0
19.0, 19.0

p5

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m39*m40*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
382.0, 938.0
19.0, 19.0

p5

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m27*m34*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
311.0, 195.0
17.0, 17.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14

MO000016963 e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
538.0, 802.0
19.0, 19.0

p5

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000007694

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m17*m977*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
475.0, 1035.0
17.0, 17.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e34

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1

Go back
675.0, 903.0
17.0, 17.0

p31

p32

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e35

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1

Go back
771.0, 915.0
17.0, 17.0

p31

p33

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1

Go back
863.0, 943.0
17.0, 17.0

p31

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e40

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1

Go back
642.0, 1086.0
19.0, 19.0

p35

p35

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e41 e42 e43 e44 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m42*m43*m44*m45*m46*0.1

nodelay

--

true

0

false

PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site

Go back
743.0, 1235.0
17.0, 17.0

p36

p36

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e46

G010228 e41 e42 e43 e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 16713969 Coordinated assembly of these factors forms the interferon-beta enhanceosome, which is responsible for the transcriptional induction of this antiviral cytokine.

Go back
489.0, 1249.0
21.0, 21.0

p37

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 16713969 The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).

Go back
185.0, 1489.0
19.0, 19.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016660 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m1636*m79*0.1

nodelay

--

true

0

false

PMID: 16713969 The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).

Go back
222.0, 1590.0
19.0, 19.0

p38

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e79 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m80*m81*0.1

nodelay

--

true

0

false

PMID: 16713969 The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).

Go back
387.0, 235.0
17.0, 17.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000000212

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m183*0.1

nodelay

--

true

0

false

PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
322.0, 1814.0
19.0, 19.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16713969 The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).

Go back
350.0, 422.0
19.0, 19.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e15 MO000019331

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m15*m3902*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
442.0, 318.0
19.0, 19.0

p5

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 MO000000210

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m16*m181*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.

Go back
426.0, 478.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000066987

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19*m41844*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members

Go back
334.0, 662.0
19.0, 19.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000103999

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19*m76904*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure 1 PMID: 16713969 Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members

Go back
573.0, 565.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000094908

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m20*m68199*0.1

nodelay

--

true

0

false

PMID: 16713969 Figure1 PMID: 16713969 TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.

Go back
542.0, 60.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.0, 155.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.1870984557311, 844.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 960.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.0, 1096.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 1040.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.8823322690733, 1027.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.0, 1096.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.8932555614534, 1112.949974496936

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 1099.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0506473836232, 1155.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
697.833070699734, 1246.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.9355982368308, 246.0130550940635

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
591.1393954939583, 1109.1291152228007

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.352465419694, 1047.2636750760037

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.0, 1038.935806003798

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0, 1114.213399075579

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 1260.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 1260.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
142.0, 1270.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 1515.6921915811265

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 1503.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.9878479129105, 1561.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
277.664979622148, 252.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
239.07692307692307, 1616.3846153846155

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.0, 1604.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.15445514457383, 1670.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 1833.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 272.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 448.72290714422616

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 434.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 336.760367953758

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
468.9430147078954, 318.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 332.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.0, 503.5672416142839

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.9121523769792, 77.76811903147812

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.0, 499.8

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 497.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 629.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.84009132311496, 688.0180979353481

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 672.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 581.3430000067614

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 576.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 584.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 673.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 585.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.3812733975551, 70.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.3511636339965, 686.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.98340247174764, 745.5150582239837

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 296.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 754.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.9855816161192, 646.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.0, 296.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.3438668042538, 684.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 686.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.5240571578817, 794.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 853.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 158.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 844.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.6079254665552, 749.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.0, 788.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.15318083721587, 796.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 615.8372875251666

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
354.0, 491.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.90158376078125, 462.04575599769936

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 708.2333781766138

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
346.0, 498.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 469.5508668509281

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.0, 216.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 484.9774073881235

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
571.0, 336.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.1845869638607, 401.0745328934242

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.0, 407.4822522096318

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 333.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.9249690339478, 384.09309917709624

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.0, 258.6332679503399

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.7690913781342, 247.90819788234876

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 248.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.0, 416.69547535069574

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
364.81326653363635, 150.19277940531467

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.9873018291627, 396.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 409.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.1899506244386, 197.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 336.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 344.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.6571853098491, 447.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.7908097149198, 197.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 513.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 265.65694969915614

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.0, 253.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.2829174186304, 155.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
617.5292602284735, 277.78163310197226

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 268.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 295.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 261.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
623.87247244023, 530.4227359831741

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 457.48714542761314

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 400.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.9893198795369, 713.4132406834243

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 721.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.91506230026, 354.1626645186823

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.0, 212.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.7172562455227, 251.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 361.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.1204572001809, 470.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 251.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 627.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 665.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.0, 729.2362661431334

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.7405375327533, 733.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.4605447861927, 920.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 955.0081344481972

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0740528189224, 212.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 957.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 462.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.8500704975418, 828.0126284062368

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 814.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 1044.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 1049.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.1716813201745, 864.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.1659646153463, 920.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.3995009355511, 835.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 932.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back