_enti_e77
_enti_e8
_enti_e74
_enti_e1
_enti_e7
_enti_e75
_enti_e76
_enti_e4
_enti_e3
_enti_e2
_enti_e47
_enti_e10
_enti_e9
_enti_e55
_enti_e5
_enti_e73
_enti_e59
_enti_e53
_enti_e11
_enti_e6
_enti_e68
_enti_e67
_enti_e56
_enti_e52
_enti_e51
_enti_e50
_enti_e54
_enti_e72
_enti_e66
_enti_e65
_enti_e64
_enti_e63
_enti_e57
_enti_e58
_enti_e61
_enti_e69
_enti_e49
_enti_e48
_enti_e60
_enti_e62
_enti_e71
_enti_e70
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g2
g1_fact_g4
g2_fact_g6
g2_fact_g7
g1_fact_g5
p1_propro_p1
PMID: 16713969
Figure1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c5 cso30:c:InputProcess connector
c4 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
c9 cso30:c:OutputProcess connector
p3_propro_p4
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c13 cso30:c:InputAssociation connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p5_propro_p6
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c16 cso30:c:InputAssociation connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p7_propro_p8
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p9_propro_p10
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p9_propro_p11
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p9_propro_p12
PMID: 16713969
Figure1
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
c37 cso30:c:OutputProcess connector
p5_propro_p13
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c38 cso30:c:InputProcess connector
c40 cso30:c:InputAssociation connector
c39 cso30:c:OutputProcess connector
p5_propro_p14
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c41 cso30:c:InputAssociation connector
c42 cso30:c:InputProcess connector
c43 cso30:c:OutputProcess connector
p5_propro_p15
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c44 cso30:c:InputAssociation connector
c45 cso30:c:InputProcess connector
c46 cso30:c:OutputProcess connector
p5_propro_p16
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c47 cso30:c:InputAssociation connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p5_propro_p17
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p5_propro_p18
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c53 cso30:c:InputAssociation connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p7_propro_p19
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p7_propro_p20
PMID: 16713969
Figure 1
PMID: 16713969
Viral PAMPs trigger multiple signaling cascades through Toll-like-receptor-dependent (TLR3, TLR7, and TLR9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p3_propro_p21
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p3_propro_p22
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c65 cso30:c:InputProcess connector
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p3_propro_p23
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c68 cso30:c:InputProcess connector
c69 cso30:c:InputProcess connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p3_propro_p24
PMID: 16713969
TRIF and MyD88 are the adaptors linking TLRs to the TRAF proteins, whereas MAVS links RIG-1 and MDA5 to TRAF3.
c72 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c74 cso30:c:InputProcess connector
c75 cso30:c:OutputProcess connector
p5_propro_p29
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c88 cso30:c:InputAssociation connector
c89 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p5_propro_p30
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c91 cso30:c:InputAssociation connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p5_propro_p25
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c76 cso30:c:InputAssociation connector
c77 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p5_propro_p26
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c79 cso30:c:InputAssociation connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p5_propro_p27
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c82 cso30:c:InputAssociation connector
c83 cso30:c:InputProcess connector
c84 cso30:c:OutputProcess connector
p5_propro_p28
PMID: 16713969
Figure 1
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site.
c85 cso30:c:InputAssociation connector
c86 cso30:c:InputProcess connector
c87 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16713969
Figure1
c94 cso30:c:InputProcess connector
c95 cso30:c:OutputProcess connector
p31_propro_p32
PMID: 16713969
Figure1
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p31_propro_p33
PMID: 16713969
Figure1
c98 cso30:c:InputProcess connector
c99 cso30:c:OutputProcess connector
p31_propro_p34
PMID: 16713969
Figure1
c100 cso30:c:InputProcess connector
c101 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 16713969
TRAF-dependent induction of the kinases JNK, IKK-alpha, IKK-beta, IKK-gamma, TBK1, and IRAK1 induce the binding of the transcription factors ATF2-cJun complex, NF-KappaB (p50-p65 complex), IRF3, and IRF7 to sequence specific positive regulatory domains (PRD) located upstream of the interferon-beta start site
c102 cso30:c:InputProcess connector
c103 cso30:c:InputProcess connector
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:InputProcess connector
c107 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 16713969
Coordinated assembly of these factors forms the interferon-beta enhanceosome, which is responsible for the transcriptional induction of this antiviral cytokine.
c108 cso30:c:InputAssociation connector
c109 cso30:c:OutputProcess connector
c110 cso30:c:OutputProcess connector
c111 cso30:c:OutputProcess connector
c112 cso30:c:OutputProcess connector
c113 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
c114 cso30:c:InputAssociation connector
c115 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
c116 cso30:c:InputAssociation connector
c117 cso30:c:InputProcess connector
c118 cso30:c:OutputProcess connector
p38_propro_p39
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
c119 cso30:c:InputAssociation connector
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 16713969
The secreted IFN-beta induces the JAK-STAT signaling pathway in neighboring cells, leading to the activation of a large battery of IFN-stimulated genes (ISGs).
c122 cso30:c:InputAssociation connector
c123 cso30:c:OutputProcess connector
TLR3_enti_MO000019398
TLR3
TLR7_enti_MO000042126
TLR7
Viral PAMPs_enti_e12
Viral PAMPs
Viral PAMPs:TLR3_enti_e13
Viral PAMPs:TLR3
TRIF_enti_MO000041125
TRIF
Viral PAMPs:TLR3:TRIF_enti_e14
Viral PAMPs:TLR3:TRIF
TRAF3_enti_MO000016963
TRAF3
Viral PAMPs:TLR3:TRIF:TRAF3_enti_e15
Viral PAMPs:TLR3:TRIF:TRAF3
TRAF6_enti_MO000000212
TRAF6
Viral PAMPs:TLR3:TRIF:TRAF6_enti_e16
Viral PAMPs:TLR3:TRIF:TRAF6
TBK1_enti_MO000019331
TBK1
TBK1{active}_enti_e17
TBK1{active}
IKK-alpha:IKK-beta:IKK-gamma_enti_MO000000210
IKK-alpha:IKK-beta:IKK-gamma
IKK-alpha:IKK-beta:IKK-gamma{active}_enti_e18
IKK-alpha:IKK-beta:IKK-gamma{active}
DDX58_enti_MO000066987
DDX58
IFIH1_enti_MO000103999
IFIH1
Viral PAMPs_enti_e19
Viral PAMPs
Viral PAMPs:DDX58_enti_e20
Viral PAMPs:DDX58
Viral PAMPs:IFIH1_enti_e21
Viral PAMPs:IFIH1
MAVS_enti_MO000094908
MAVS
Viral PAMPs:DDX58:MAVS_enti_e22
Viral PAMPs:DDX58:MAVS
Viral PAMPs:IFIH1:MAVS_enti_e23
Viral PAMPs:IFIH1:MAVS
Viral PAMPs:IFIH1:MAVS:TRAF3_enti_e24
Viral PAMPs:IFIH1:MAVS:TRAF3
Viral PAMPs:DDX58:MAVS:TRAF3_enti_e25
Viral PAMPs:DDX58:MAVS:TRAF3
IRF-3:IRF-7_enti_MO000007694
IRF-3:IRF-7
JNK_enti_MO000000023
JNK
JNK{active}_enti_e26
JNK{active}
Viral PAMPs:TLR7_enti_e27
Viral PAMPs:TLR7
TLR9_enti_MO000042012
TLR9
Viral PAMPs:TLR9_enti_e28
Viral PAMPs:TLR9
MyD88_enti_MO000016573
MyD88
Viral PAMPs:TLR7:MyD88_enti_e29
Viral PAMPs:TLR7:MyD88
Viral PAMPs:TLR9:MyD88_enti_e30
Viral PAMPs:TLR9:MyD88
Viral PAMPs:TLR7:MyD88:TRAF3:TRAF6_enti_e31
Viral PAMPs:TLR7:MyD88:TRAF3:TRAF6
Viral PAMPs:TLR9:MyD88:TRAF3:TRAF6_enti_e32
Viral PAMPs:TLR9:MyD88:TRAF3:TRAF6
p50:RelA-p65_enti_MO000016632
p50:RelA-p65
ATF-2:C-Jun_enti_e33
ATF-2:C-Jun
ATF-2:C-Jun{active}_enti_e34
ATF-2:C-Jun{active}
IRF-3:IRF-7{active}_enti_e35
IRF-3:IRF-7{active}
p50:RelA-p65{active}_enti_e36
p50:RelA-p65{active}
IRAK1:IKK-alpha_enti_e37
IRAK1:IKK-alpha
IRAK1:IKK-alpha{active}_enti_e38
IRAK1:IKK-alpha{active}
IRF-7:IRF-7_enti_e39
IRF-7:IRF-7
IRF-7:IRF-7{active}_enti_e40
IRF-7:IRF-7{active}
ATF-2:C-Jun{active}_enti_e41
ATF-2:C-Jun{active}
IRF-3:IRF-7{active}_enti_e42
IRF-3:IRF-7{active}
p50:RelA-p65{active}_enti_e43
p50:RelA-p65{active}
IRF-7:IRF-7{active}_enti_e44
IRF-7:IRF-7{active}
IFN-beta_enti_e45
IFN-beta
IFN-beta:(ATF2:C-Jun):(IRF-3:IRF-7):(p50:RelA-p65):(IRF-7:IRF-7){active}_enti_e46
IFN-beta:(ATF2:C-Jun):(IRF-3:IRF-7):(p50:RelA-p65):(IRF-7:IRF-7){active}
IFN-beta_enti_G010228
IFN-beta
IFNbeta_enti_MO000016660
IFNbeta
JAK_enti_e78
JAK
JAK{active}_enti_e79
JAK{active}
STAT_enti_e80
STAT
STAT{active}_enti_e81
STAT{active}
ISGs_enti_e82
ISGs