MyD88_enti_MO000016573
MyD88
_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e11
_enti_e55
_enti_e12
_enti_e6
_enti_e59
_enti_e53
_enti_e50
_enti_e56
_enti_e54
_enti_e51
_enti_e52
_enti_e57
_enti_e58
_enti_e61
_enti_e60
_enti_e62
g1_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID:16753195,9851930,11607032
For example, lipopolysaccharide (LPS), a common structure of the cell wall of Gram-negative bacteria, is recognized by TLR4 ; double-stranded RNA (dsRNA), which has long been considered a viral PAMP, triggers TLR3 signaling
PMID: 16753195,9851930
LPS has long been identified as ligand for TLR4 via analysis of mice with a point mutation in the gene encoding TLR4
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p1_propro_p2
PMID:16753195,9851930,11607032
For example, lipopolysaccharide (LPS), a common structure of the cell wall of Gram-negative bacteria, is recognized by TLR4 ; double-stranded RNA (dsRNA), which has long been considered a viral PAMP, triggers TLR3 signaling
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 16753195,15229469,15207506
Natural or synthetic oligodeoxynucleotides (OND) containing an unmethylated CpG motif (CpG) can activate TLR9, which exclusively couples to the MyD88-dependent pathway
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 16753195
Upon stimulation of TLRs, MyD88 is recruited to the TIR domain of TLRs.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 16753195
MyD88 further recruits IRAK4 to form TLRMyD88IRAK4 signal complex.
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p6_propro_p6
pMID: 16753195
Then the signal complex (TLRMyD88IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p7_propro_p7
pMID: 16753195
Then the signal complex (TLRMyD88IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 16753195
The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16753195
The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex
c23 cso30:c:InputProcess connector
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 16753195,15229469
The IRAK1TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 16753195,15229469
The IRAK1TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1
c29 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c31 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 16753195,15229469
The IRAK1TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1
c33 cso30:c:InputProcess connector
c34 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 16753195,15229469
The IRAK1TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 16753195
The activated TAK1 subsequently activates the IκB kinases (IKKs), which phosphorylates IκB and leads to activation of NF-κB.
c38 cso30:c:InputAssociation connector
c39 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 16753195
The activated TAK1 subsequently activates the IκB kinases (IKKs), which phosphorylates IκB and leads to activation of NF-κB.
c41 cso30:c:InputAssociation connector
c42 cso30:c:InputProcess connector
c43 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 16753195
The activated TAK1 subsequently activates the IκB kinases (IKKs), which phosphorylates IκB and leads to activation of NF-κB.
c44 cso30:c:InputAssociation connector
c45 cso30:c:InputProcess connector
c46 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 16753195,10094049,16186825,15229469
Activation of TAK1 also results in the activation of MAPKs, including c-Jun N-terminal kinase (JNK), leading to activation of AP-1
c47 cso30:c:InputAssociation connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p15_propro_p18
PMID: 16753195,10094049,16186825,15229469
Activation of TAK1 also results in the activation of MAPKs, including c-Jun N-terminal kinase (JNK), leading to activation of AP-1
c50 cso30:c:InputAssociation connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 16753195,11058605,11385577,12527755,12766759,12514169
There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-κB, which is TLR independent
c53 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p19_propro_p20
PMID: 16753195,11058605,11385577,12527755,12766759,12514169
There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-κB, which is TLR independent
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 16753195,11058605,11385577,12527755,12766759,12514169
There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-κB, which is TLR independent
c59 cso30:c:InputAssociation connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p21_propro_p22
PMID: 16753195,11058605,11385577,12527755,12766759,12514169
There is evidence that NOD1 and NOD2 can recognize the core structures of bacterial peptidoglycan in the cytoplasm to activate NF-κB, which is TLR independent
c62 cso30:c:InputAssociation connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 16753195
Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif
c66 cso30:c:InputProcess connector
c232 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p23_propro_p24
PMID: 16753195
Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif
c69 cso30:c:InputProcess connector
c233 cso30:c:InputProcess connector
c70 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 16753195
Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif
c71 cso30:c:InputProcess connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 16753195,16143103
More recently, it was shown that the glucocorticoid receptor (GR) can selectively transrepress the transcription of a subset of genes (such as Scyb9), of which promoters utilize IRF3 as an essential coactivator of NF-κB binding to the κB sites upon LPS stimulation
c74 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 16753195,16143103
More recently, it was shown that the glucocorticoid receptor (GR) can selectively transrepress the transcription of a subset of genes (such as Scyb9), of which promoters utilize IRF3 as an essential coactivator of NF-κB binding to the κB sites upon LPS stimulation
c77 cso30:c:InputInhibitor connector
c78 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 16753195,16143103
For example, both dsRNA and LPS can activate transcription of the IP10 gene
c79 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p28_propro_p29
PMID: 16753195,16143103
For example, both dsRNA and LPS can activate transcription of the IP10 gene
c81 cso30:c:InputAssociation connector
c82 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 16753195,15229469,15733829
TLR3 signals through myeloid differentiation primary response protein-88 (MyD88)-independent and Toll/interleukin receptor (TIR) domain-containing adaptor-inducing IFN-β (TRIF, also known as TICAM-1)-dependent pathways
c84 cso30:c:InputProcess connector
c83 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c87 cso30:c:InputProcess connector
c86 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p31_propro_p32
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c89 cso30:c:InputProcess connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 16753195,14739303,16153868
Besides IKKε and TBK1, TRAF6, IKKβ and receptorinteractor protein-1 (RIP1) also interact with TRIF
c92 cso30:c:InputProcess connector
c93 cso30:c:InputProcess connector
c94 cso30:c:OutputProcess connector
p33_propro_p34
PMID: 16753195,14739303,16153868
Besides IKKε and TBK1, TRAF6, IKKβ and receptorinteractor protein-1 (RIP1) also interact with TRIF
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c98 cso30:c:InputAssociation connector
c99 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p35_propro_p36
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c101 cso30:c:InputAssociation connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p35_propro_p37
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c104 cso30:c:InputAssociation connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p35_propro_p38
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c107 cso30:c:InputAssociation connector
c108 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
p25_propro_p39
PMID: 16753195
Recently, it has been shown that two cytoplasmic RNA helicase proteins, Mda-5 and RIG-I, are sensors of viral dsRNA, which initiate antiviral responses via the adaptor protein VISA/IPS-1/MAVS/Cardif
c110 cso30:c:InputProcess connector
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 16753195,12721283,14519765,14993454,15229469
In addition, two other adaptors, TIR-containing adaptor protein (TIRAP, also known as Mal) and TIR-containing protein (TIRP, also known as TRAM and TICAM-2), participate in those two pathways, respectively
c114 cso30:c:InputProcess connector
c113 cso30:c:InputProcess connector
c115 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 16753195
TLR4 makes use of both TRIF and MyD88 adaptors to activate IRF3/7, NF-κB and AP-1 upon the stimulation of LPS.
c116 cso30:c:InputProcess connector
c117 cso30:c:InputProcess connector
c118 cso30:c:OutputProcess connector
p31_propro_p42
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c119 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
p31_propro_p43
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c122 cso30:c:InputProcess connector
c123 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p33_propro_p44
PMID: 16753195,14739303,16153868
Besides IKKε and TBK1, TRAF6, IKKβ and receptorinteractor protein-1 (RIP1) also interact with TRIF
c125 cso30:c:InputProcess connector
c126 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p33_propro_p45
PMID: 16753195,14739303,16153868
Besides IKKε and TBK1, TRAF6, IKKβ and receptorinteractor protein-1 (RIP1) also interact with TRIF
c128 cso30:c:InputProcess connector
c129 cso30:c:InputProcess connector
c130 cso30:c:OutputProcess connector
p33_propro_p46
PMID: 16753195,14739303,16153868
Besides IKKε and TBK1, TRAF6, IKKβ and receptorinteractor protein-1 (RIP1) also interact with TRIF
c131 cso30:c:InputProcess connector
c132 cso30:c:InputProcess connector
c133 cso30:c:OutputProcess connector
p35_propro_p47
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c134 cso30:c:InputAssociation connector
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p35_propro_p48
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c137 cso30:c:InputAssociation connector
c138 cso30:c:InputProcess connector
c139 cso30:c:OutputProcess connector
p35_propro_p49
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c140 cso30:c:InputAssociation connector
c141 cso30:c:InputProcess connector
c142 cso30:c:OutputProcess connector
p35_propro_p50
PMID: 16753195
The adaptor protein TRIF has been demonstrated to interact with the TRAF family-member-associated NF-κB activator (TANK) binding kinase 1 (TBK1) and IKKε (also known as IKKi) as well as IRF3/7 and thereby to facilitate TBK1 and IKKε to phosphorylate and activate IRF3/7.
c143 cso30:c:InputAssociation connector
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 16753195,16127453,16153868
For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study
c146 cso30:c:InputProcess connector
c147 cso30:c:InputProcess connector
c149 cso30:c:InputProcess connector
c148 cso30:c:OutputProcess connector
p51_propro_p52
PMID: 16753195,16127453,16153868
For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study
c150 cso30:c:InputProcess connector
c151 cso30:c:InputProcess connector
c152 cso30:c:InputProcess connector
c153 cso30:c:OutputProcess connector
p40_propro_p53
PMID: 16753195,12721283,14519765,14993454,15229469
In addition, two other adaptors, TIR-containing adaptor protein (TIRAP, also known as Mal) and TIR-containing protein (TIRP, also known as TRAM and TICAM-2), participate in those two pathways, respectively
c154 cso30:c:InputProcess connector
c155 cso30:c:InputProcess connector
c156 cso30:c:OutputProcess connector
p4_propro_p54
PMID: 16753195
Upon stimulation of TLRs, MyD88 is recruited to the TIR domain of TLRs.
c157 cso30:c:InputProcess connector
c158 cso30:c:InputProcess connector
c159 cso30:c:OutputProcess connector
p5_propro_p55
PMID: 16753195
MyD88 further recruits IRAK4 to form TLRMyD88IRAK4 signal complex.
c160 cso30:c:InputProcess connector
c161 cso30:c:InputProcess connector
c162 cso30:c:OutputProcess connector
p6_propro_p56
pMID: 16753195
Then the signal complex (TLRMyD88IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.
c163 cso30:c:InputProcess connector
c164 cso30:c:InputProcess connector
c165 cso30:c:OutputProcess connector
p7_propro_p57
pMID: 16753195
Then the signal complex (TLRMyD88IRAK4) recruits IRAK1 and thereby phosphorylates and activates it.
c166 cso30:c:InputProcess connector
c167 cso30:c:OutputProcess connector
p8_propro_p58
PMID: 16753195
The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex
c168 cso30:c:InputProcess connector
c169 cso30:c:OutputProcess connector
p9_propro_p59
PMID: 16753195
The activated IRAK1 autophosphorylates residues in its N-terminus, which leads to recruitment and binding of TRAF6 to the receptor signaling complex
c170 cso30:c:InputProcess connector
c171 cso30:c:InputProcess connector
c172 cso30:c:OutputProcess connector
p10_propro_p60
PMID: 16753195,15229469
The IRAK1TRAF6 complex then disassociates from the receptor and interacts with another complex consisting of TAK1, TAB1 and TAB2, followed by the phosphorylation and activation of TAK1
c173 cso30:c:InputProcess connector
c174 cso30:c:OutputProcess connector
c175 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c176 cso30:c:InputAssociation connector
c177 cso30:c:InputProcess connector
c178 cso30:c:OutputProcess connector
p61_propro_p62
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c179 cso30:c:InputAssociation connector
c180 cso30:c:InputProcess connector
c181 cso30:c:OutputProcess connector
p51_propro_p63
PMID: 16753195,16127453,16153868
For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study
c182 cso30:c:InputProcess connector
c183 cso30:c:InputProcess connector
c184 cso30:c:OutputProcess connector
p51_propro_p64
PMID: 16753195,16127453,16153868
For instance, VISA forms a complex with FADD and RIP1 , and it also interacts with TRAF6 in our study
c185 cso30:c:InputProcess connector
c186 cso30:c:InputProcess connector
c187 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c188 cso30:c:InputProcess connector
c189 cso30:c:InputProcess connector
c190 cso30:c:OutputProcess connector
p61_propro_p66
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c191 cso30:c:InputAssociation connector
c192 cso30:c:InputProcess connector
c193 cso30:c:OutputProcess connector
p65_propro_p67
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c194 cso30:c:InputProcess connector
c195 cso30:c:InputProcess connector
c196 cso30:c:OutputProcess connector
p61_propro_p68
PMID: 16753195
Both the RIP1/FADD and the TRAF6/TAK1 pathways are sufficient to activate NF-κB.
c197 cso30:c:InputAssociation connector
c198 cso30:c:InputProcess connector
c199 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 16753195,15064760,16115877
However, there also exist some distinct explanations about the involvement of RIP1 in TRIF-mediated NF-κB activation. It has been suggested that TRIF interacts with RIP1, and this interaction mediates TLR3-triggered NF-κB activation
c200 cso30:c:InputAssociation connector
c201 cso30:c:InputProcess connector
c202 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 16753195
The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-κB.
PMID: 16753195,16166516
By asking why the activation dynamics of NF-κB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-κB
c203 cso30:c:InputAssociation connector
c204 cso30:c:InputAssociation connector
c205 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 16753195
The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-κB.
PMID: 16753195,16166516
By asking why the activation dynamics of NF-κB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-κB
c206 cso30:c:InputProcess connector
c207 cso30:c:InputProcess connector
c208 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 16753195
The TRIF-dependent pathway first stimulates activation of IRF3 leading to production of TNF alpha, which in turn triggers TNFR signaling to activate NF-κB.
PMID: 16753195,16166516
By asking why the activation dynamics of NF-κB show damped oscillatory behavior when cells are stimulated by tumor necrosis factor alpha (TNF alpha) but stable behavior when stimulated by LPS, however, proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNF alpha, which is induced by IRF3 (activated by TLR4/TRIF-mediated pathway in the first response to LPS) and signals through TNF alpha receptor (TNFR)/RIP1 pathway to activate NF-κB
c209 cso30:c:InputAssociation connector
c210 cso30:c:InputProcess connector
c211 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 16753195
The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKKβ, IKKε and/or TBK1 for activation of IRF3/7.
c212 cso30:c:InputAssociation connector
c213 cso30:c:InputProcess connector
c214 cso30:c:OutputProcess connector
p73_propro_p74
PMID: 16753195
The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKKβ, IKKε and/or TBK1 for activation of IRF3/7.
c215 cso30:c:InputAssociation connector
c216 cso30:c:InputProcess connector
c217 cso30:c:OutputProcess connector
p73_propro_p75
PMID: 16753195
The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKKβ, IKKε and/or TBK1 for activation of IRF3/7.
c218 cso30:c:InputAssociation connector
c219 cso30:c:InputProcess connector
c220 cso30:c:OutputProcess connector
p73_propro_p76
PMID: 16753195
The TLR3 and TLR4 initiated signaling pathways converge at TRIF, which signals through IKKβ, IKKε and/or TBK1 for activation of IRF3/7.
c221 cso30:c:InputAssociation connector
c222 cso30:c:InputProcess connector
c223 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 16753195
Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-κB (NF-κB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.
c224 cso30:c:InputAssociation connector
c225 cso30:c:OutputProcess connector
p77_propro_p78
PMID: 16753195
Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-κB (NF-κB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.
c226 cso30:c:InputAssociation connector
c227 cso30:c:OutputProcess connector
p77_propro_p79
PMID: 16753195
Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-κB (NF-κB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.
c228 cso30:c:InputAssociation connector
c229 cso30:c:OutputProcess connector
p77_propro_p80
PMID: 16753195
Stimulation of TLRs by PAMPs induces activation and translocation to nucleus of nuclear factor-κB (NF-κB), interferon regulatory factor 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which collaborate to induce transcription of various cytokines such as alpha/beta interferon (IFN-alpha/beta), leading to clearance of the infectious pathogens.
c230 cso30:c:InputAssociation connector
c231 cso30:c:OutputProcess connector
TLR4_enti_MO000019394
TLR4
LPS_enti_MO000016882
LPS
LPS:TLR4_enti_e5
LPS:TLR4
TLR3_enti_MO000019398
TLR3
dsRNA_enti_MO000022224
dsRNA
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
TLR9_enti_MO000042012
TLR9
CpG motif_enti_e13
CpG motif
TLR9:CpGmotif_enti_e14
TLR9:CpGmotif
MyD88_enti_MO000019348
MyD88
CpGmotif:TLR9:MyD88_enti_e15
CpGmotif:TLR9:MyD88
IRAK-4_enti_MO000039077
IRAK-4
CpGmotif:TLR9:MyD88:IRAK-4_enti_e16
CpGmotif:TLR9:MyD88:IRAK-4
IRAK_enti_MO000000213
IRAK
CpGmotif:TLR9:MyD88:IRAK-4:IRAK_enti_e17
CpGmotif:TLR9:MyD88:IRAK-4:IRAK
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}_enti_e18
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}_enti_e19
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}
TRAF6_enti_MO000000212
TRAF6
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}:TRAF6_enti_e20
CpGmotif:TLR9:MyD88:IRAK-4:IRAK{p}{p}:TRAF6
IRAK:TRAF6_enti_e21
IRAK:TRAF6
TAB1_enti_MO000016588
TAB1
TAK1_enti_MO000016574
TAK1
TAB2_enti_MO000022125
TAB2
TAK1:TAB1:TAB2_enti_e22
TAK1:TAB1:TAB2
IRAK:TRAF6:TAK1:TAB1:TAB2_enti_e23
IRAK:TRAF6:TAK1:TAB1:TAB2
IRAK:TRAF6:TAK1{p}:TAB1:TAB2_enti_e24
IRAK:TRAF6:TAK1{p}:TAB1:TAB2
IKK_enti_MO000000248
IKK
IKK{active}_enti_e25
IKK{active}
IkappaB_enti_MO000000215
IkappaB
IkappaB{p}_enti_e26
IkappaB{p}
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e27
NF-kappaB{active}
JNK_enti_MO000000023
JNK
JNK{active}_enti_e28
JNK{active}
AP-1_enti_MO000000276
AP-1
AP-1{active}_enti_e29
AP-1{active}
Nod1_enti_MO000020434
Nod1
Nod2_enti_MO000020461
Nod2
PGN_enti_MO000042032
PGN
Nod1:PGN_enti_e30
Nod1:PGN
Nod2:PGN_enti_e31
Nod2:PGN
DDX58_enti_MO000066987
DDX58
IFIH1_enti_MO000103999
IFIH1
DDX58:dsRNA_enti_e33
DDX58:dsRNA
IFIH1:dsRNA_enti_e34
IFIH1:dsRNA
MAVS_enti_MO000094908
MAVS
DDX58:dsRNA:MAVS_enti_e35
DDX58:dsRNA:MAVS
GR_enti_e36
GR
Ligand_enti_e37
Ligand
GR:Ligand_enti_e38
GR:Ligand
Scyb9_enti_e39
Scyb9
IP10_enti_e40
IP10
TRIF_enti_MO000041125
TRIF
TRAM_enti_MO000041132
TRAM
dsRNA:TLR3:TRIF_enti_e41
dsRNA:TLR3:TRIF
TBK1_enti_MO000019331
TBK1
dsRNA:TLR3:TRIF:TBK1_enti_e42
dsRNA:TLR3:TRIF:TBK1
IKK-i_enti_MO000016608
IKK-i
dsRNA:TLR3:TRIF:IKK-i_enti_e43
dsRNA:TLR3:TRIF:IKK-i
IKK-beta_enti_MO000000211
IKK-beta
dsRNA:TLR3:TRIF:IKK-beta_enti_e44
dsRNA:TLR3:TRIF:IKK-beta
dsRNA:TLR3:TRIF:TRAF6_enti_e45
dsRNA:TLR3:TRIF:TRAF6
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_e46
IRF-3{p}
IRF-7_enti_MO000007702
IRF-7
IRF-7{p}_enti_e47
IRF-7{p}
IFIH1:dsRNA:MAVS_enti_e48
IFIH1:dsRNA:MAVS
LPS:TLR4:TRAM_enti_e49
LPS:TLR4:TRAM
LPS:TLR4:TRAM:TRIF_enti_e63
LPS:TLR4:TRAM:TRIF
LPS:TLR4:TRAM:TRIF:IKK-i_enti_e64
LPS:TLR4:TRAM:TRIF:IKK-i
LPS:TLR4:TRAM:TRIF:TBK1_enti_e65
LPS:TLR4:TRAM:TRIF:TBK1
LPS:TLR4:TRAM:TRIF:IKK-beta_enti_e66
LPS:TLR4:TRAM:TRIF:IKK-beta
RIP1_enti_e67
RIP1
LPS:TLR4:TRAM:TRIF:RIP1_enti_e68
LPS:TLR4:TRAM:TRIF:RIP1
dsRNA:TLR3:TRIF:RIP1_enti_e69
dsRNA:TLR3:TRIF:RIP1
DDX58:dsRNA:MAVS:RIP1:FADD_enti_e70
DDX58:dsRNA:MAVS:RIP1:FADD
FADD_enti_MO000016899
FADD
IFIH1:dsRNA:MAVS:RIP1:FADD_enti_e71
IFIH1:dsRNA:MAVS:RIP1:FADD
TIRAP_enti_MO000022528
TIRAP
LPS:TLR4:TIRAP_enti_e72
LPS:TLR4:TIRAP
LPS:TLR4:TIRAP:MyD88_enti_e73
LPS:TLR4:TIRAP:MyD88
LPS:TLR4:TIRAP:MyD88:IRAK-4_enti_e74
LPS:TLR4:TIRAP:MyD88:IRAK-4
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK_enti_e75
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}_enti_e76
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}_enti_e77
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}:TRAF6_enti_e78
LPS:TLR4:TIRAP:MyD88:IRAK-4:IRAK{p}{p}:TRAF6
DDX58:dsRNA:MAVs:TRAF6_enti_e79
DDX58:dsRNA:MAVs:TRAF6
IFIH1:dsRNA:MAVS:TRAF6_enti_e80
IFIH1:dsRNA:MAVS:TRAF6
IFIH1:dsRNA:MAVS:TRAF6:TAK1_enti_e81
IFIH1:dsRNA:MAVS:TRAF6:TAK1
DDX58:dsRNA:MAVs:TRAF6:TAK1_enti_e82
DDX58:dsRNA:MAVs:TRAF6:TAK1
TNF-alpha_enti_MO000000289
TNF-alpha
TNF-alpha_enti_G010329
TNF-alpha
TNF-alphaR_enti_e83
TNF-alphaR
TNF-alpha:TNF-alphaR_enti_e84
TNF-alpha:TNF-alphaR
cytokines_enti_e85
cytokines