_enti_e1
_enti_e2
_enti_e4
_enti_e3
_enti_e16
_enti_e55
_enti_e14
_enti_e15
_enti_e53
_enti_e59
_enti_e54
_enti_e52
_enti_e51
_enti_e50
_enti_e56
_enti_e61
_enti_e57
_enti_e58
_enti_e60
_enti_e62
g1_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 16846592,15864272
The IFN proteins group into two classes: type I (IFN-greek small letter alpha and -β) and type II (IFN-γ), which bind two distinct cell surface receptors, type I and type II IFN receptors, respectively
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c2 cso30:c:InputProcess connector
c1 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p1_propro_p2
PMID: 16846592,15864272
The IFN proteins group into two classes: type I (IFN-greek small letter alpha and -β) and type II (IFN-γ), which bind two distinct cell surface receptors, type I and type II IFN receptors, respectively
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 16846591,11404376
After IFN stimulation, hundreds of cellular genes known as interferon-stimulated genes (ISGs) are transcriptionally activated
c10 cso30:c:InputAssociation connector
c11 cso30:c:OutputProcess connector
p4_propro_p5
PMID: 16846591,11404376
After IFN stimulation, hundreds of cellular genes known as interferon-stimulated genes (ISGs) are transcriptionally activated
c12 cso30:c:InputAssociation connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 16846591
These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2′5′ oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.
c14 cso30:c:InputAssociation connector
c15 cso30:c:OutputProcess connector
p6_propro_p7
PMID: 16846591
These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2′5′ oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.
c159 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p6_propro_p8
PMID: 16846591
These genes encode proteins such as RNase L, dsRNA-dependent protein kinase (PKR), and 2′5′ oligoadenylate synthetase (OAS), that mediate antiviral activities directly or indirectly.
c162 cso30:c:InputAssociation connector
c19 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p9_propro_p10
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c23 cso30:c:InputProcess connector
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
PMID: 16846591
The production of IFN-β relies in part on the C-terminal phosphorylation and activation of the cytoplasmic interferon regulatory factor (IRF)-3 transcription factor
PMID: 16846591
he C-terminal region comprises a cluster of phosphoacceptor sites 382GGASSLENTVDLHISNSHPLSLTSDQYKAYLQD414 and virus-induced phosphorylation is thought to realign the C-terminal domain and relieve autoinhibition
c26 cso30:c:InputAssociation connector
c27 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
PMID: 16846591
The production of IFN-β relies in part on the C-terminal phosphorylation and activation of the cytoplasmic interferon regulatory factor (IRF)-3 transcription factor
PMID: 16846591
he C-terminal region comprises a cluster of phosphoacceptor sites 382GGASSLENTVDLHISNSHPLSLTSDQYKAYLQD414 and virus-induced phosphorylation is thought to realign the C-terminal domain and relieve autoinhibition
c29 cso30:c:InputAssociation connector
c30 cso30:c:InputProcess connector
c31 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c34 cso30:c:InputProcess connector
c35 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c36 cso30:c:InputProcess connector
c37 cso30:c:InputProcess connector
c38 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c39 cso30:c:InputAssociation connector
c40 cso30:c:OutputProcess connector
p16_propro_p17
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c41 cso30:c:InputAssociation connector
c42 cso30:c:OutputProcess connector
p16_propro_p18
PMID: 16846591
Once phosphorylated, IRF-3 dimerizes and translocates to the nucleus, associates with CREB binding protein (CBP/p300) co-activators and participates in the transcriptional activation of the IFN-β and human IFN-alpha1 (or murine IFN-alpha4) promoters
c43 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c45 cso30:c:InputAssociation connector
c46 cso30:c:OutputProcess connector
p20_propro_p21
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c47 cso30:c:InputAssociation connector
c48 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c49 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c52 cso30:c:InputAssociation connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p23_propro_p24
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c55 cso30:c:InputAssociation connector
c56 cso30:c:InputProcess connector
c57 cso30:c:OutputProcess connector
p23_propro_p25
PMID: 16846591
Binding of the newly secreted IFN-β and IFN-alpha1 to receptors on adjacent cells leads to the activation of the Jak/STAT signaling pathway.
c58 cso30:c:InputAssociation connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 16846591,15743772,10938111
Similarly to IRF-3, IRF-7 is activated by virus-induced phosphorylation at its C-terminus
PMID: 16846591,10938111,11073981,9877175,12702806,15367631
The serine rich C-terminal region between aa471487, is the target of virus-induced phosphorylation and by TBK1 and IKK epsilon
c61 cso30:c:InputAssociation connector
c62 cso30:c:InputProcess connector
c87 cso30:c:InputAssociation connector
c88 cso30:c:InputAssociation connector
c63 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c66 cso30:c:InputProcess connector
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c69 cso30:c:InputProcess connector
c70 cso30:c:OutputProcess connector
p29_propro_p30
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c71 cso30:c:InputProcess connector
c72 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c73 cso30:c:InputProcess connector
c74 cso30:c:InputProcess connector
c75 cso30:c:OutputProcess connector
p31_propro_p32
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c76 cso30:c:InputProcess connector
c77 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c79 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p33_propro_p34
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c82 cso30:c:InputAssociation connector
c81 cso30:c:OutputProcess connector
p33_propro_p35
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c83 cso30:c:InputAssociation connector
c84 cso30:c:OutputProcess connector
p33_propro_p36
PMID: 16846591,9822609,9541017,12213596
Active IRF-7 homodimers or heterodimers with IRF-3, bind to promoters of all IFN-alpha genes, and are thus ultimately responsible for the induction of delayed type I IFNs and amplification of the interferon response
c85 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 16846591,14625680
Furthermore, macrophages primed with interferon (IFN)-γ increases the expression of FcγR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing
c89 cso30:c:InputAssociation connector
c90 cso30:c:OutputProcess connector
p37_propro_p38
PMID: 16846591,14625680
Furthermore, macrophages primed with interferon (IFN)-γ increases the expression of FcγR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing
c91 cso30:c:InputAssociation connector
c92 cso30:c:OutputProcess connector
p37_propro_p39
PMID: 16846591,14625680
Furthermore, macrophages primed with interferon (IFN)-γ increases the expression of FcγR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing
c93 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p37_propro_p40
PMID: 16846591,14625680
Furthermore, macrophages primed with interferon (IFN)-γ increases the expression of FcγR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing
c95 cso30:c:InputAssociation connector
c96 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 16846591,14625680
Furthermore, macrophages primed with interferon (IFN)-γ increases the expression of FcγR, inducible nitric oxide synthase (iNOS), TRAIL (TNF-related apoptosis inducing ligand), cell adhesion molecules, and production of IL-1, resulting in enhanced tumor cell killing
c97 cso30:c:InputAssociation connector
c98 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 16846591,12872134
As IFN-β is known to upregulate p53 expression and thereby the apoptotic cellular response, it can be argued that cell death induced by Ad-IRF-3 could be mediated by IFN-alpha/β
c99 cso30:c:InputAssociation connector
c100 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c101 cso30:c:InputAssociation connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p27_propro_p43
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c104 cso30:c:InputAssociation connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p27_propro_p44
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c107 cso30:c:InputAssociation connector
c108 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
p27_propro_p45
PMID: 16846591,11846975
Viral entry or engagement of TLR3 or TLR4 induces the activation of latent transcription factors involved in immunomodulation, including IRF-3, NF-κB and ATF-2/c-Jun
c110 cso30:c:InputAssociation connector
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 16846591,14976261,14976262,12626561
Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/β following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA
c113 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c115 cso30:c:OutputProcess connector
p46_propro_p47
PMID: 16846591,14976261,14976262,12626561
Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/β following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA
c116 cso30:c:InputProcess connector
c117 cso30:c:InputProcess connector
c118 cso30:c:OutputProcess connector
p46_propro_p48
PMID: 16846591,14976261,14976262,12626561
Plasmacytoid dendritic cells (pDC) are major IFN producing cells and stand out amongst other cells in their ability to produce high amounts of IFN-greek small letter alpha/β following engagement of TLR9 by unmethylated DNA or stimulation of hTLR7/mTLR8 by single stranded viral RNA
c119 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 16846591,15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c122 cso30:c:InputProcess connector
c123 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p49_propro_p50
PMID: 16846591,15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c125 cso30:c:InputProcess connector
c126 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 16846591,14991609,15492225
Coccia et al. hypothesize that the regulation of IFN-alpha production in pDCs may not be mediated by the positive feedback effect of IFN-β due to constitutive expression of IRF-7 and the ability of MyD88 to recruit IRF-7, but not IRF-3, through a molecular complex including TRAF6 and IRAK4
c128 cso30:c:InputProcess connector
c129 cso30:c:InputProcess connector
c130 cso30:c:InputProcess connector
c132 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p51_propro_p52
PMID: 16846591,14991609,15492225
Coccia et al. hypothesize that the regulation of IFN-alpha production in pDCs may not be mediated by the positive feedback effect of IFN-β due to constitutive expression of IRF-7 and the ability of MyD88 to recruit IRF-7, but not IRF-3, through a molecular complex including TRAF6 and IRAK4
c133 cso30:c:InputProcess connector
c134 cso30:c:InputProcess connector
c135 cso30:c:InputProcess connector
c136 cso30:c:InputProcess connector
c137 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 16846591,16612387
In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway
c138 cso30:c:InputProcess connector
c139 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
p53_propro_p54
PMID: 16846591,16612387
In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway
c141 cso30:c:InputProcess connector
c142 cso30:c:InputProcess connector
c143 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 16846591,16612387
In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway
c144 cso30:c:InputProcess connector
c145 cso30:c:OutputProcess connector
p55_propro_p56
PMID: 16846591,16612387
In addition, IKK-alpha associated with and phosphorylated IRF-7, thus identifying a role for IKK-alpha in the TLR7/9 signaling pathway
c146 cso30:c:InputProcess connector
c147 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 16846591, 15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c148 cso30:c:InputAssociation connector
c149 cso30:c:OutputProcess connector
p57_propro_p59
PMID: 16846591, 15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c150 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p57_propro_p60
PMID: 16846591, 15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c152 cso30:c:InputAssociation connector
c153 cso30:c:OutputProcess connector
p57_propro_p61
PMID: 16846591, 15800576
pDC utilize a MyD88-dependent pathway of IFN-greek small letter alpha/β induction, which is also dependent on IRF-7
c154 cso30:c:InputAssociation connector
c155 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975
The ISGF3 complex (ISGF3γ/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2′5′ oligoadenylate synthase and IRF-7
c156 cso30:c:InputProcess connector
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
p58_propro_p62
PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975
The ISGF3 complex (ISGF3γ/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2′5′ oligoadenylate synthase and IRF-7
c16 cso30:c:InputProcess connector
c160 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p58_propro_p63
PMID: 16846591,11256746,9822609,11585785,9541017,11544356,11846975
The ISGF3 complex (ISGF3γ/IRF-9-STAT1-STAT2) binds to interferon-stimulated response elements (ISRE) found in numerous IFN-induced gene promoters such as PKR, 2′5′ oligoadenylate synthase and IRF-7
c18 cso30:c:InputProcess connector
c163 cso30:c:InputProcess connector
c164 cso30:c:OutputProcess connector
IFNalpha_enti_e5
IFNalpha
IFNbeta_enti_MO000016660
IFNbeta
Type I IFN receptor_enti_e6
Type I IFN receptor
IFNbeta:Type I IFN receptor_enti_e7
IFNbeta:Type I IFN receptor
IFNalpha:Type I IFN receptor_enti_e8
IFNalpha:Type I IFN receptor
IFNgamma_enti_MO000016665
IFNgamma
Type II IFN receptor_enti_e9
Type II IFN receptor
IFNgamma:TypeII IFN receptor_enti_e10
IFNgamma:TypeII IFN receptor
ISGs_enti_e11
ISGs
RNase L_enti_e12
RNase L
PKR_enti_MO000008179
PKR
OAS_enti_e13
OAS
IRF-3_enti_MO000007694
IRF-3
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
dsRNA_enti_MO000022224
dsRNA
TLR4_enti_MO000019394
TLR4
LPS_enti_MO000016882
LPS
LPS:TLR4_enti_e17
LPS:TLR4
IRF-3{p}_enti_e18
IRF-3{p}
IRF-3{p}:IRF-3{p}_enti_e19
IRF-3{p}:IRF-3{p}
IRF-3{p}:IRF-3{p}_enti_e20
IRF-3{p}:IRF-3{p}
CBP_enti_MO000017462
CBP
IRF-3{p}:IRF-3{p}:CBP_enti_e21
IRF-3{p}:IRF-3{p}:CBP
IFN-beta_enti_G010228
IFN-beta
IFNA1(h)_enti_G000307
IFNA1(h)
IFNA4(m)_enti_G009107
IFNA4(m)
IFNalpha1:Type I IFN receptor_enti_e22
IFNalpha1:Type I IFN receptor
JAK_enti_e23
JAK
JAK{active}_enti_e24
JAK{active}
STATs_enti_MO000016656
STATs
STATs{active}_enti_e25
STATs{active}
IRF-7_enti_MO000007702
IRF-7
IRF-7{p}_enti_MO000041457
IRF-7{p}
IRF-7{p}:IRF-7{p}_enti_e26
IRF-7{p}:IRF-7{p}
IRF-7{p}:IRF-3{p}_enti_e27
IRF-7{p}:IRF-3{p}
IRF-7{p}:IRF-7{p}_enti_e28
IRF-7{p}:IRF-7{p}
IRF-7{p}:IRF-3{p}_enti_e29
IRF-7{p}:IRF-3{p}
IFN-alpha_enti_e30
IFN-alpha
IRF-7{p}:IRF-7{p}:IFN-alpha_enti_e31
IRF-7{p}:IRF-7{p}:IFN-alpha
IRF-7{p}:IRF-3{p}:IFN-alpha_enti_e32
IRF-7{p}:IRF-3{p}:IFN-alpha
IFN-alpha_enti_e33
IFN-alpha
TBK1_enti_MO000019331
TBK1
IKK-i_enti_MO000016608
IKK-i
TLR9_enti_MO000042012
TLR9
iNOS_enti_G010514
iNOS
FCgammaR_enti_e34
FCgammaR
TRAIL_enti_e35
TRAIL
IL-1_enti_MO000000214
IL-1
IL-1_enti_e37
IL-1
p53_enti_G010432
p53
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e36
NF-kappaB{active}
ATF-2_enti_MO000000062
ATF-2
ATF-2{active}_enti_e38
ATF-2{active}
CpG DNA_enti_e39
CpG DNA
TLR9:CpG DNA_enti_e40
TLR9:CpG DNA
TLR7(h)_enti_MO000042127
TLR7(h)
TLR8_enti_MO000042007
TLR8
ssRNA_enti_e41
ssRNA
ssRNA:TLR7_enti_e42
ssRNA:TLR7
ssRNA:TLR8_enti_e43
ssRNA:TLR8
MyD88_enti_MO000016573
MyD88
TLR9:CpGDNA:MyD88_enti_e44
TLR9:CpGDNA:MyD88
ssRNA:TLR7:MyD88_enti_e45
ssRNA:TLR7:MyD88
IRAK-4_enti_MO000039077
IRAK-4
TRAF6_enti_MO000000212
TRAF6
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6_enti_e46
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6
TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6_enti_e47
TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6
IKK-alpha_enti_MO000000210
IKK-alpha
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha_enti_e48
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha
TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha_enti_e49
TLR7:ssRNA:MyD88:IRAK-4:IRF-7:TRAF6:IKK-alpha
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha_enti_e63
TLR9:CpGDNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha
TLR7:ssRNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha_enti_e64
TLR7:ssRNA:MyD88:IRAK-4:IRF-7{p}:TRAF6:IKK-alpha
ISGF3_enti_e65
ISGF3
PKR_enti_e66
PKR
ISGF3:PKR_enti_e67
ISGF3:PKR
OAS_enti_e68
OAS
ISGF3:OAS_enti_e69
ISGF3:OAS
IRF-7_enti_e70
IRF-7
ISGF3:IRF-7_enti_e71
ISGF3:IRF-7
IFNalpha1(h)_enti_MO000116973
IFNalpha1(h)