_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e4
_enti_e2
_enti_e55
_enti_e59
_enti_e53
_enti_e54
_enti_e52
_enti_e56
_enti_e50
_enti_e51
_enti_e61
_enti_e57
_enti_e58
_enti_e60
_enti_e62
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 16885502
MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 16885502
MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
c5 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 16885502
MALP-2 was found to induce self-tolerance as measured by TNF-{alpha} production but also, to induce cross-tolerance to LPS.
c7 cso30:c:InputAssociation connector
c8 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 16885502, 1698311
CD14 recognizes and binds LPS with high-affinity.
c9 cso30:c:InputProcess connector
c10 cso30:c:InputProcess connector
c11 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 16885502, 9605151, 10452971, 8675286
CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.
c12 cso30:c:InputProcess connector
c13 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 16885502, 9605151, 10452971, 8675286
CD14 has also been implicated in activation of the inflammatory response to gram-positive bacterial components such as BLP and LTA.
c15 cso30:c:InputProcess connector
c16 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 16885502, 11067937, 10725698
Multiple studies have confirmed that LPS signals primarily through TLR4.
c18 cso30:c:InputProcess connector
c19 cso30:c:InputProcess connector
c20 cso30:c:OutputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 16885502, 10754329, 10215628
After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 16885502, 10754329, 10215628
After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 16885502, 10754329, 10215628
After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
PMID: 16885502
IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c89 cso30:c:InputInhibitor connector
c30 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 16885502, 11357875
In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
c49 cso30:c:InputProcess connector
c51 cso30:c:InputAssociation connector
c50 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 16885502, 11357875
In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
c52 cso30:c:InputProcess connector
c54 cso30:c:InputAssociation connector
c53 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 16885502, 11357875
In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
c55 cso30:c:InputProcess connector
c57 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 16885502, 11357875
In turn, these adaptor molecules activate the I{kappa}B kinase (IKK) complex and MAPKs, JNK, p38, and ERK1/2, leading to the activation of NF-{kappa}B and AP-1, respectively, and ultimately, to transcription of inflammatory target genes.
c58 cso30:c:InputProcess connector
c60 cso30:c:InputAssociation connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 16885502
The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.
c61 cso30:c:InputProcess connector
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 16885502
The mycobacterial components, lipoarabinomannan (LAM) and soluble tuberculosis factor (STF), activated cells expressing TLR2.
c64 cso30:c:InputProcess connector
c65 cso30:c:InputProcess connector
c66 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 16885502, 10383454, 9734363, 11960013
IRAKs bind to TRAF6.
c67 cso30:c:InputProcess connector
c68 cso30:c:InputProcess connector
c69 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 16885502, 10383454, 9734363, 11960013
IRAKs bind to TRAF6.
c70 cso30:c:InputProcess connector
c71 cso30:c:InputProcess connector
c72 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 16885502, 10383454, 9734363, 11960013
IRAKs bind to TRAF6.
c73 cso30:c:InputProcess connector
c74 cso30:c:InputProcess connector
c75 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 16885502, 10383454, 9734363, 11960013
IRAKs bind to TRAF6.
c76 cso30:c:InputProcess connector
c77 cso30:c:InputProcess connector
c78 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 16885502
When cells were pretreated with BLP for 24 h, there was a marked decrease in IRAK-1 protein levels compared with nave cells.
c79 cso30:c:InputAssociation connector
c81 cso30:c:InputInhibitor connector
c80 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 16885502, 12055225
LPS causes IRAK-1 activation, phosphorylation, and subsequent degradation.
PMID: 16885502, 11960013
IRAK-4 has been demonstrated to act upstream of IRAK-1 and is responsible for phosphorylation of IRAK-1.
c88 cso30:c:InputAssociation connector
c93 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 16885502, 10754329, 10215628
After ligand binding, TLRs sequentially recruit the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)and TNF receptor-associated factor 6 (TRAF6).
PMID: 16885502
IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
c90 cso30:c:InputProcess connector
c91 cso30:c:InputProcess connector
c108 cso30:c:InputInhibitor connector
c92 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 16885502, 14751757
Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF--activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1.
PMID: 16885502
IRAK-M prevents dissociation of IRAK-1 and IRAK-4 from MyD88 and inhibits formation of the IRAK-TRAF-6 complex.
c83 cso30:c:InputProcess connector
c109 cso30:c:InputInhibitor connector
c85 cso30:c:OutputProcess connector
c94 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 16885502, 14751757
Following phosphorylation of IRAK-1, IRAK-1 and TRAF-6 dissociate from the receptor complex, and TRAF-6 interacts with TGF--activated kinase-1 (TAK-1), TAK-1/2-binding protein, resulting in activation of TAK-1.
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c97 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 16885502
TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B
c31 cso30:c:InputProcess connector
c36 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 16885502, 10602462
Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
c33 cso30:c:InputProcess connector
c35 cso30:c:InputAssociation connector
c34 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 16885502, 10602462
Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
c99 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 16885502, 10602462
Activation of IKK complex results in phosphorylation of I{kappa}B{alpha} and I{kappa}Bbeta, ubiquitination, and degradation of I{kappa}B, and release of the active NF-{kappa}B complex.
c101 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
c87 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 16885502
TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B.
PMID: 16885502, 11303728
Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
c37 cso30:c:InputProcess connector
c39 cso30:c:InputAssociation connector
c38 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 16885502
TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B.
PMID: 16885502, 11303728
Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
c40 cso30:c:InputProcess connector
c103 cso30:c:InputAssociation connector
c41 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 16885502
TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B.
PMID: 16885502, 11303728
Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
c45 cso30:c:InputProcess connector
c104 cso30:c:InputAssociation connector
c46 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 16885502
TAK-1 phosphorylates the MAPKs and the IKK complex, a cytoplasmic inhibitor of NF-{kappa}B.
PMID: 16885502, 11303728
Three major MAPKs, ERK1/2, JNK, and p38, are phosphorylated and activated following LPS stimulation.
c43 cso30:c:InputProcess connector
c105 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 16885502
Following activation, NF-{kappa}B is translocated to the nucleus, where it activates the transcription of proinflammatory genes.
c106 cso30:c:InputProcess connector
c107 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 16885502, 12133836
BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
c110 cso30:c:InputProcess connector
c112 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 16885502, 12133836
BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
c113 cso30:c:InputProcess connector
c115 cso30:c:InputAssociation connector
c114 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 16885502, 12133836
BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
c116 cso30:c:InputProcess connector
c118 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 16885502, 12133836
BLP stimulation of THP-1 monocytes induces activation of ERK1/2, JNK, and p38.
c119 cso30:c:InputProcess connector
c121 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
MALP2_enti_e5
MALP2
TLR2_enti_MO000019397
TLR2
TLR2:MALP2_enti_e6
TLR2:MALP2
TNF-alpha_enti_MO000000289
TNF-alpha
TNF-alpha_enti_G010329
TNF-alpha
LPS_enti_MO000016882
LPS
CD14_enti_MO000018132
CD14
LPS:CD14_enti_e11
LPS:CD14
BLP_enti_e12
BLP
BLP:CD14_enti_e13
BLP:CD14
LTA_enti_e14
LTA
LTA:CD14_enti_e15
LTA:CD14
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e16
LPS:TLR4
MyD88_enti_MO000016573
MyD88
LPS:TLR4:MYD88_enti_e17
LPS:TLR4:MYD88
IRAK_enti_MO000000213
IRAK
LPS:TLR4:MYD88:IRAK_enti_e18
LPS:TLR4:MYD88:IRAK
TRAF6_enti_MO000000212
TRAF6
LPS:TLR4:MYD88:IRAK:TRAF6_enti_e19
LPS:TLR4:MYD88:IRAK:TRAF6
IKK_enti_MO000000248
IKK
IKK{p}_enti_e20
IKK{p}
JNK_enti_MO000000023
JNK
JNK{p}_enti_e22
JNK{p}
p38_enti_MO000000022
p38
p38{p}_enti_e23
p38{p}
ERK1_enti_MO000004670
ERK1
ERK1{p}_enti_e24
ERK1{p}
ERK2_enti_MO000004676
ERK2
ERK2{p}_enti_e25
ERK2{p}
AP-1_enti_MO000000276
AP-1
AP-1{active}_enti_e26
AP-1{active}
LAM_enti_e27
LAM
TLR2:LAM_enti_e28
TLR2:LAM
STF_enti_e29
STF
STF:TLR2_enti_e30
STF:TLR2
IRAK1_enti_e31
IRAK1
IRAK-2_enti_MO000016566
IRAK-2
IRAK2:TRAF6_enti_e33
IRAK2:TRAF6
IRAK-4_enti_MO000039077
IRAK-4
IRAK4:TRAF6_enti_e34
IRAK4:TRAF6
IRAK-M_enti_MO000016569
IRAK-M
IRAKM:TRAF6_enti_e35
IRAKM:TRAF6
IRAK1_enti_G011134
IRAK1
protein remnants_enti_e37
LPS:TLR4:MYD88:IRAK1_enti_e38
LPS:TLR4:MYD88:IRAK1
LPS:TLR4:MYD88:IRAK1:TRAF6_enti_e32
LPS:TLR4:MYD88:IRAK1:TRAF6
LPS:TLR4:MYD88:IRAK1{p}:TRAF6_enti_e39
LPS:TLR4:MYD88:IRAK1{p}:TRAF6
IRAK1:TRAF6_enti_e36
IRAK1:TRAF6
LPS:TLR4:MYD88_enti_e40
LPS:TLR4:MYD88
TAK1_enti_MO000016574
TAK1
TAB_enti_MO000022124
TAB
IRAK1:TRAF6:TAK1:TAB2_enti_e41
IRAK1:TRAF6:TAK1:TAB2
NF-kappaB:IkappaB_enti_e21
NF-kappaB:IkappaB
NF-kappaB:IkappaB{p}_enti_e42
NF-kappaB:IkappaB{p}
NF-kappaB:IkappaB{p}{ub}_enti_e43
NF-kappaB:IkappaB{p}{ub}
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB_enti_e44
NF-kappaB