1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16930560.csml convertedTime:2009.07.01.10:56

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors: from the discovery of NFkappaB to new insights intotranscriptional regulations in innate immunity.
Authors Doyle SL, O'Neill LA.
Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2,Ireland. doylesl@tcd.ie
Abstract Toll-like receptors (TLRs) are key components of the innate immune system,functioning as pattern recognition receptors that recognise a wide range ofmicrobial pathogens. TLRs represent a primary line of defence against invadingpathogens in mammals, plants and insects. Recognition of microbial components byTLRs triggers a cascade of cellular signals that culminates in the activation ofNFkappaB which leads to inflammatory gene expression and clearance of theinfectious agent. The history of NFkappaB began with the TLR4 ligandlipopolysaccharide (LPS), a component of the cell wall of Gram-negativebacteria, since this was the stimulus first used to activate NFkappaB inpre-B-cells. However, since those early days it has been a circuitous route,made possible by drawing on information provided by many different fields, thathas led us not only to the discovery of TLRs but also to an understanding of thecomplex pathways that lead from TLR ligation to NFkappaB activation. In thisreview we will summarize the current knowledge of TLR-mediated NFkappaBactivation, and also the recent discoveries that subtle differences in kappaBbinding sequences and NFkappaB dimer formation result in specific geneexpression profiles.
PMID 16930560
Model Abstract

Entity

G010228:IFN-beta G010229:IL-2 G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010514:iNOS G010657:IL-12 p40 MO000000058:NF-kappaB MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000215:IkappaB MO000000248:IKK MO000000289:TNF-alpha MO000001935:Btk MO000007384:IL-6 MO000007694:IRF-3 MO000016573:MyD88 MO000016588:TAB1 MO000016599:IKK-gamma MO000016608:IKK-i MO000016882:LPS MO000017061:IL-2 MO000017264:IL-8 MO000017462:CBP MO000018132:CD14 MO000019331:TBK1{active} MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019420:LBP MO000019422:TLR6 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022125:TAB2 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10:IP-10 e100:IRF3:IP-10 e101:IP-10 e102:IFN-beta:IRF3 e103:LPS:TLR4:TRAM e104:LPS:TLR4:TRAM:TRIF e105:TBK1 e106:IRF3:p65 e107:Glucocorticoids e108:IRG-1 e109:GARG16 e11:Triacylated lipopeptides e110:Src kinases e111:NF-kappaB{active} e12:TLR1:TLR2:Triacylated lipopeptides e13:TLR2:TLR6 e14:diacylated lipopeptides e15:TLR2:TLR1:diacylated lipopeptides e16:TLR5:flagellin e17:ssRNA e18:TLR7:ssRNA e19:TLR8:ssRNA e2: e20:CpG motifs e21:TLR9:CpG motifs e22:fungal, protozoal products e23:TLR2:fungal,protozoal products e24:NF-KappaB:IKappaB e25:IRAK1{p}:TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1 e29:LPS:TLR4 e3: e30:LPS:TLR4:MyD88:TIRAP e31:LPS:TLR4:MyD88:IRAK4 e32:IRAK1 e33:LPS:TLR4:MyD88:IRAK4:IRAK1{p} e34:LPS:TLR4:MyD88:IRAK4:IRAK1 e35:IRAK1{p} e36:LPS:TLR4:MyD88:IRAK4 e37:IRAK1{p}:TRAF6 e38:TAK1 e39:TAK1:TAB1:TAB2 e4: e40:IRAK1{p}:TRAF6:TAK1:TAB1:TAB2 e41:IRAK1{p}:TRAF6{ub}:TAK1{ub}:TAB1:TAB2 e42:IRAK1{p}:TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1 e43:TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1 e44:proteosome remnants e45:IKK{p} e46: e47: e48: e49:dsRNA:TLR3:TRIF:TRAF6 e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR1:TLR2 e60: e61: e62: e63:RIP1 e64:dsRNA:TLR3:TRIF:RIP1 e65:dsRNA:TLR3:TRIF:RIP1:TRAF6 e66:LPS:TLR4:MyD88 e67:LPS:TLR4:MyD88:TIRAP:Btk e68:LPS:TLR4:MyD88:TIRAP:Btk{p} e69:LPS:TLR4:MyD88:TIRAP{p}:Btk{p} e7: e70:NF-kappaB e71:IKBZ e72:TNFalpha gene e73:NFKappaB:TNFalpha e74:IL-1gene e75:IL-1:NFKappaB e76:IL-2 gene e77:IL-2:NFKappaB e78:IL-1 e79:Il-8 e8: e80:Il-1 e81:NF-KappaB:IKappaB{p} e82:proteosome remnants e83:PTKs e84:NF-kappaB{p} e85:TNF-alpha receptor e86:TNF-alpha:receptor e87:Il-1R e88:IL-1:receptor e89:PKA e9: e90:NFKappaB{p}:CBP e91:NFKappaB{p}:CBP e92:NFKappaB:CBP:IKBZ e93:IKBZ e94:dsRNA:TLR3:TRIF:TBK1 e95:dsRNA:TLR3:TRIF:IKK-i e96:IRF-3{active} e97:IRF-3:IRF-3 e98:IRF-3:IRF-3 e99:IFN-beta

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p83 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97
Model Detail
688.0, 1358.0
24.0, 24.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p85

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
589.0, 1299.0
29.5, 29.5

IL-2

--

G010229

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

p48

true true true true

csml-variable:Double

m93218

10

false

infinite

0

unit false false false
TRANSFACG010229

--

Go back
428.0, 1146.0
24.5, 24.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p57 p72

p49 p74

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
425.0, 1191.0
22.0, 22.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p43 p56 p95 p96

p46 p75

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
636.0, 1182.0
23.0, 23.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p55 p58

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
532.0, 1370.0
24.0, 24.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p94

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
602.0, 1352.0
20.0, 20.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
501.0, 611.0
29.0, 29.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
886.0, 696.0
20.0, 20.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66 p68

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
921.0, 747.0
22.0, 22.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66 p67

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
478.0, 440.0
28.5, 28.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p30 p33

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
548.0, 506.0
24.0, 24.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
823.0, 897.0
26.0, 26.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66

p28

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
167.0, 1265.0
26.0, 26.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46 p75

p60

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
437.0, 391.0
30.0, 30.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
180.0, 1162.0
23.0, 23.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p74

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
637.0, 327.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78 p79 p89

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
615.0, 253.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1097.0, 651.0
30.0, 30.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
840.0, 718.0
24.0, 24.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
697.0, 251.0
22.0, 22.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
138.0, 248.0
27.0, 27.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
688.0, 1554.0
24.0, 24.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

--

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
196.0, 1382.0
24.0, 24.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
783.0, 749.0
26.0, 26.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
247.0, 225.0
26.0, 26.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
683.0, 301.0
25.0, 25.0

TBK1{active}

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

p76 p89

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
244.0, 370.0
24.5, 24.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
531.0, 105.0
24.5, 24.5

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
617.0, 111.0
21.0, 21.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4 p11

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1041.0, 283.0
21.0, 21.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
919.0, 105.0
26.0, 26.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
105.0, 179.0
22.0, 22.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
247.0, 417.0
26.0, 26.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
192.0, 110.0
24.0, 24.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p51

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
236.0, 270.0
24.0, 24.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p52

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
1094.0, 600.0
28.0, 28.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
898.0, 24.0
27.0, 27.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1208.0, 262.0
31.5, 31.5

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
531.0, 317.0
25.0, 25.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
424.0, 486.0
24.0, 24.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
881.0, 219.0
22.0, 22.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p87

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
544.0, 222.0
23.0, 23.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
963.0, 273.0
25.0, 25.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30 p32 p76 p77

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
1067.0, 425.0
25.0, 25.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p29

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1141.0, 103.0
29.5, 29.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
1166.0, 432.0
27.5, 27.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1027.0, 105.0
26.5, 26.5

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
242.75, 97.8607411477037
898.1227753023817, 1304.074269739056

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
771.0, 1173.5
51.41947466171404, 11.140886176704718

IP-10

--

e10

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p41

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
846.0, 1159.5
44.55644124453587, 12.624325019285166

IRF3:IP-10

--

e100

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p41

p83

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
844.0, 1305.0
31.920415224913498, 17.024221453287193

IP-10

--

e101

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p83 p91

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
777.0, 1307.5
45.72897917202366, 12.956544098740038

IFN-beta:IRF3

--

e102

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p42

p85

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
319.5, 93.0
25.031381904936683, 34.92750963479537

LPS:TLR4:TRAM

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p86

p87

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
392.0, 86.0
23.558823529411768, 39.26470588235295

LPS:TLR4:TRAM:TRIF

--

e104

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p87

p88

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
811.0, 189.0
25.0, 25.0

TBK1

--

e105

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
877.0, 1104.0
22.058823529411764, 36.76470588235295

IRF3:p65

--

e106

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p90

p91

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1009.0, 1359.0
37.392767031118574, 21.189234650967194

Glucocorticoids

--

e107

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p90

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
812.0, 1355.0
40.5363321799308, 21.619377162629764

IRG-1

--

e108

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p92

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
716.0, 1399.0
40.79584775086505, 21.757785467128027

GARG16

--

e109

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p93

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
783.0, 30.0
42.41379310344826, 24.03448275862069

Triacylated lipopeptides

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
983.0, 1404.5
25.919999999999998, 19.44

Src kinases

--

e110

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p94 p95

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
505.0, 927.0
29.0, 29.0

NF-kappaB{active}

--

e111

cso30:c:Protein

cso30:i:CC_CellComponent

--

p97

--

true true true true

csml-variable:Double

m112

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
804.5, 92.0
22.238982679237004, 43.04319228239421

TLR1:TLR2:Triacylated lipopeptides

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
244.5, 475.0
31.779370104982497, 38.91351441426429

TLR2:TLR6

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p4

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
173.0, 431.0
53.49032800672835, 30.31118587047939

diacylated lipopeptides

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
247.5, 545.0
25.406270554702918, 49.17342688007017

TLR2:TLR1:diacylated lipopeptides

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
976.5, 92.0
22.449682087261564, 43.45099758824819

TLR5:flagellin

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
967.0, 46.5
42.30326295585412, 23.26679462571977

ssRNA

--

e17

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p8 p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1081.5, 89.0
21.37579478184609, 41.37250602937954

TLR7:ssRNA

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1169.5, 181.0
21.84477088357816, 42.28020171015128

TLR8:ssRNA

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
250.75, 134.3475506746998
930.4323563472203, 1350.987781416162

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1253.0, 399.0
53.65145228215768, 14.307053941908713

CpG motifs

--

e20

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1169.5, 514.0
21.063144047358033, 40.76737557553169

TLR9:CpG motifs

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
171.0, 568.0
50.714886459209424, 28.738435660218666

fungal, protozoal products

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p11

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
243.5, 629.0
25.89563692172769, 50.1205875904407

TLR2:fungal,protozoal products

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
683.5, 583.0
25.091984669221798, 30.724879186802212

NF-KappaB:IKappaB

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p53

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1023.0, 1100.0
26.470588235294123, 44.11764705882353

IRAK1{p}:TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p27

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
264.5, 91.0
23.6730980048235, 45.81889936417452

LPS:TLR4

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
236.80829322146684, 108.47576380970172
956.5138625442954, 1406.8724728255677

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
477.5, 86.0
28.385208295100032, 39.60726738851166

LPS:TLR4:MyD88:TIRAP

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p17 p35

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
247.0, 905.0
25.411764705882355, 42.352941176470594

LPS:TLR4:MyD88:IRAK4

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
427.0, 641.5
41.76695512175489, 25.756288991748843

IRAK1

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
242.0, 1051.0
27.352941176470587, 45.58823529411766

LPS:TLR4:MyD88:IRAK4:IRAK1{p}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
242.0, 979.0
27.352941176470587, 45.58823529411766

LPS:TLR4:MyD88:IRAK4:IRAK1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
474.0, 855.0
36.46341463414633, 29.170731707317067

IRAK1{p}

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
238.0, 1123.0
27.352941176470587, 45.58823529411766

LPS:TLR4:MyD88:IRAK4

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
530.5, 746.0
26.243292784535907, 32.13464422596234

IRAK1{p}:TRAF6

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p23

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1091.0, 556.5
34.879999999999995, 26.160000000000004

TAK1

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1127.5, 727.0
33.04899981648009, 46.114883464855936

TAK1:TAB1:TAB2

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
243.99537472714667, 86.3025923618527
928.9232785873897, 1407.014717679767

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1130.0, 815.0
27.264705882352942, 45.44117647058824

IRAK1{p}:TRAF6:TAK1:TAB1:TAB2

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24 p31 p34

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1133.0, 898.0
29.029411764705884, 48.38235294117647

IRAK1{p}:TRAF6{ub}:TAK1{ub}:TAB1:TAB2

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1131.0, 988.0
26.470588235294123, 44.11764705882353

IRAK1{p}:TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27 p13

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
995.0, 1036.0
26.38235294117647, 43.97058823529412

TRAF6{ub}:TAK1{ub}{p}:TAB2{p}:TAB1

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27 p31 p34

p28

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1100.0, 1175.0
31.912693854106834, 30.848937392303288

proteosome remnants

--

e44

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
743.0, 897.0
26.0, 26.0

IKK{p}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p53

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
984.9105829615207, 286.55410884253956
85.91350113674055, 143.4318620672705

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
962.9284129482487, 249.85506229495763
138.8463011776304, 231.80272315248493

--

e47

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
962.9284129482487, 249.85506229495763
138.8463011776304, 231.80272315248493

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
996.0, 438.0
24.26470588235294, 40.441176470588246

dsRNA:TLR3:TRIF:TRAF6

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
240.5, 131.0
23.6730980048235, 45.81889936417452

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p15 p55 p56 p57 p64 p67 p68 p74 p75 p86 p90 p94 p95

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
392.0, 952.0
560.229829241653, 508.06690286906

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
452.5089945922084, 964.0404469848986
327.5831776198865, 492.4180249572821

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
399.30280969216324, 958.7811804284371
545.624209857327, 494.5045420121857

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
400.34606821961484, 959.8244389558888
543.5376928024232, 492.4180249572821

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
392.0, 952.0
560.229829241653, 508.06690286906

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
392.0, 952.0
560.229829241653, 508.06690286906

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
400.34606821961484, 959.8244389558888
543.5376928024232, 492.4180249572821

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
800.957342761131, 1160.651705490373
35.00008154593938, 31.68428434685046

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
709.1505923453681, 1306.707899333636
99.10956010792738, 89.72023336086079

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
392.0, 952.0
560.229829241653, 508.06690286906

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
688.5, 104.0
23.671221463089488, 28.985169138476913

TLR1:TLR2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
524.0430185559787, 1177.7807334436304
17.74165552081817, 8.542278584097653

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
523.4505744589352, 1152.3056372707583
60.72551994696246, 109.30593590453248

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
548.9256706318076, 1223.3989289159829
9.479105552696561, 9.479105552696575

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
742.5, 226.0
19.434493861944055, 31.515395451801165

RIP1

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1007.0, 377.0
25.235294117647054, 42.05882352941177

dsRNA:TLR3:TRIF:RIP1

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
967.0, 405.0
25.235294117647054, 42.05882352941177

dsRNA:TLR3:TRIF:RIP1:TRAF6

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
237.5, 314.0
28.385208295100032, 39.60726738851166

LPS:TLR4:MyD88

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p36 p70

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
246.0, 706.0
28.235294117647058, 47.05882352941177

LPS:TLR4:MyD88:TIRAP:Btk

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p37

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
242.0, 771.0
27.352941176470587, 45.58823529411766

LPS:TLR4:MyD88:TIRAP:Btk{p}

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
246.0, 831.0
27.352941176470587, 45.58823529411766

LPS:TLR4:MyD88:TIRAP{p}:Btk{p}

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
279.0, 242.81231524194536
817.8716868042568, 1158.9030543647038

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
689.0, 787.0
29.0, 29.0

NF-kappaB

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p62 p63 p64 p67 p68 p97

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
758.0, 1252.0
12.513564078578108, 28.877455565949482

IKBZ

--

e71

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p71

p69 p72 p73 p74 p75

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
463.0, 1052.5
49.700185725656674, 10.768373573892278

TNFalpha gene

--

e72

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p14

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
475.0, 1087.5
49.16945230136282, 13.931344818719468

NFKappaB:TNFalpha

--

e73

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p14

p43

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
522.0, 1072.5
51.3239586097108, 11.120191032104005

IL-1gene

--

e74

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
575.0, 1134.5
49.709436873232185, 14.084340447415787

IL-1:NFKappaB

--

e75

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p26

p44

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
627.0, 1044.5
45.09949588750332, 9.771557442292384

IL-2 gene

--

e76

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p40

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
641.0, 1091.5
45.26613525327847, 12.825404988428902

IL-2:NFKappaB

--

e77

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

p45

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
499.0, 1297.0
33.166089965397916, 17.688581314878896

IL-1

--

e78

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

p47

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
468.0, 1254.0
31.038062283737027, 16.55363321799308

Il-8

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p50

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
302.0, 119.51133222490463
780.4114398076894, 1133.1574106007647

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
380.0, 1565.0
15.006548175865294, 34.63049579045837

Il-1

--

e80

cso30:c:Protein

cso30:i:CC_Extracellular

--

p47

p61

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
660.0, 649.0
31.463414634146343, 25.17073170731707

NF-KappaB:IKappaB{p}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
727.0, 705.0
25.98506605399196, 25.11889718552556

proteosome remnants

--

e82

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1054.5, 1263.0
18.570738579190987, 30.114711209498896

PTKs

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p55 p56 p57

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
665.0, 863.0
29.0, 29.0

NF-kappaB{p}

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62 p63 p64 p67 p68

p65

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
249.5, 1316.0
28.90158172231986, 44.463971880492096

TNF-alpha receptor

--

e85

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p60

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
251.5, 1218.0
25.080026310019733, 48.541986406489805

TNF-alpha:receptor

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

p62 p97

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
474.5, 1481.0
27.165202108963094, 41.792618629173994

Il-1R

--

e87

cso30:c:Protein

cso30:i:CC_PlasmaMembrane

--

--

p61

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
560.5, 1477.0
22.19820214865161, 42.96426222319667

IL-1:receptor

--

e88

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p63

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
662.0, 547.5
32.09498893137452, 19.791909841014288

PKA

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p64

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
238.0, 135.96770760216555
955.9163677803724, 1376.0699316022021

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
814.5, 814.0
18.93534410931511, 23.18613564405932

NFKappaB{p}:CBP

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p39

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
606.5, 978.0
18.93534410931511, 23.18613564405932

NFKappaB{p}:CBP

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p49 p50 p58 p69 p90 p14 p26 p40

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
661.5, 1287.0
21.456597540833183, 29.939438429069547

NFKappaB:CBP:IKBZ

--

e92

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p69

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
747.0, 1105.0
34.46366782006921, 18.380622837370243

IKBZ

--

e93

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p70

p71

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
998.0, 314.0
19.499999999999993, 32.50000000000001

dsRNA:TLR3:TRIF:TBK1

--

e94

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p76

p78

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1066.0, 358.0
19.499999999999993, 32.50000000000001

dsRNA:TLR3:TRIF:IKK-i

--

e95

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p77

p79

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
649.0, 371.0
22.0, 22.0

IRF-3{active}

--

e96

cso30:c:Protein

cso30:i:CC_CellComponent

--

p78 p79 p89

p80

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
548.5, 388.0
22.568905182469585, 27.635394100983163

IRF-3:IRF-3

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p81

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
862.5, 1051.0
18.453591068155305, 22.596233961006504

IRF-3:IRF-3

--

e98

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p81

p90 p92 p93 p96 p41 p42

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
709.0, 1220.5
54.68293977182277, 11.84797028389493

IFN-beta

--

e99

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p42

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
167.0, 177.0
26.0, 26.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 16930560 LPS was known to be concentrated from the plasma by LPS binding protein (LBP), and CD14 was identified as a receptor for LPS on the surface of the cells

Go back
1256.0, 462.0
23.0, 23.0

p7

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000042012

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m20*m19828*0.1

nodelay

--

true

0

false

PMID: 16930560 The anti-viral TLRs are TLR3 which recognises double stranded RNA, TLR7 and TLR8 which bothrecognise single strandedRNA,andTLR9which recognises CpGmotifs, that exist in both virus and bacteria

Go back
210.0, 508.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m3964*m22*0.1

nodelay

--

true

0

false

PMID: 16930560 Finally various fungal and protozoal products are sensed by TLR2.

Go back
562.0, 584.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000058 MO000000215

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c111 : 1

m24*m186*0.1

nodelay

--

true

0

false

PMID: 16930560 As is now well known, NFkB is regulated by an inhibitory molecule called inhibitory kB (IkB) which retains NFkB in the cytoplasm under normal conditions.

Go back
1060.0, 1034.0
23.0, 23.0

p13

p13

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e42

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 16930560,11518704,12242293 Phosphorylation of TAK1 and TAB2 occurs initiating the dissociation of TRAF6/TAK1/TAB1/TAB2 from the membrane to the cytosol, and IRAK-1 degradation PMID: 16930560,11460167,11518704,12242293 Ubiquitination of TRAF6 and TAK1 activate the complex, and phosphorylation of TAK1 and TAB2 initiates the release of the complex from the membrane

Go back
516.0, 1006.0
23.0, 23.0

p14

p14

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e91 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c57 : 1

m92*m73*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
219.0, 41.0
25.0, 25.0

p15

p15

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e5

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 16930560 On TLR ligation, TLR4 dimers and TLR2 heterodimerised with TLR1 or TLR6 recruit Mal and MyD88 to their TIR domains, TLR7/8/9 recruit MyD88 alone.

Go back
541.0, 267.0
22.0, 22.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000016573

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c99 : 1

m30*m1572*0.1

nodelay

--

true

0

false

PMID: 16930560 On TLR ligation, TLR4 dimers and TLR2 heterodimerised with TLR1 or TLR6 recruit Mal and MyD88 to their TIR domains, TLR7/8/9 recruit MyD88 alone. PMID: 16930560 MyD88, which has a C-terminal TIR domain, and an N-terminal death domain associates with the TIR domain of the TLRs and upon binding of ligand to the receptor MyD88 recruits IRAK4 to the TLR receptor complex through the interaction of the death domains of both molecules and facilitates IRAK-4-mediated phosphorylation of IRAK-1.

Go back
371.0, 689.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000039077

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m31*m17258*0.1

nodelay

--

true

0

false

PMID: 16930560 MyD88, which has a C-terminal TIR domain, and an N-terminal death domain associates with the TIR domain of the TLRs and upon binding of ligand to the receptor MyD88 recruits IRAK4 to the TLR receptor complex through the interaction of the death domains of both molecules and facilitates IRAK-4-mediated phosphorylation of IRAK-1.

Go back
435.0, 749.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 16930560 The presence of IRAK-4 is required for the recruitment of IRAK-1 to the receptor complex and for the activation and subsequent degradation of IRAK-1 protein.

Go back
411.0, 825.0
25.0, 25.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 16930560 MyD88, which has a C-terminal TIR domain, and an N-terminal death domain associates with the TIR domain of the TLRs and upon binding of ligand to the receptor MyD88 recruits IRAK4 to the TLR receptor complex through the interaction of the death domains of both molecules and facilitates IRAK-4-mediated phosphorylation of IRAK-1.

Go back
596.0, 26.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019396 MO000019397

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3963*m3964*0.1

nodelay

--

true

0

false

PMID: 16930560 The other antibacterial TLRs are TLR2, which in combination with TLR1 recognises triacylated lipopeptides, or in combination with TLR6 recognises diacylated lipopeptides; and TLR5 which recognises bacterial flagellin.

Go back
419.0, 881.0
25.0, 25.0

p20

p20

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e33

e35 e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 16930560,11960013,8837778,11923871 Phosphorylated IRAK-1 subsequently dissociates from the receptor complex and associates with TRAF6

Go back
480.0, 786.0
24.0, 24.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m183*m36*0.1

nodelay

--

true

0

false

PMID: 16930560,11960013,8837778,11923871 Phosphorylated IRAK-1 subsequently dissociates from the receptor complex and associates with TRAF6

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974.0, 652.0
27.0, 27.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 MO000022125 MO000016588

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m39*m6433*m1583*0.1

nodelay

--

true

0

false

PMID: 16930560 IRAK1 binds TRAF6 which in turn binds a pre-formed membrane bound complex of TAB1/ TAK1/TAB2. PMID: 16930560 TRAF6 and IRAK1 then dissociate from the receptor complex and interact with a membrane bound pre-associated complex of TGF-b activated kinase (TAK1) and two TAK1-binding proteins (TAB), termed TAB1 and TAB2

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538.0, 676.0
27.0, 27.0

p22

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m38*m40*0.1

nodelay

--

true

0

false

PMID: 16930560 IRAK1 binds TRAF6 which in turn binds a pre-formed membrane bound complex of TAB1/ TAK1/TAB2. PMID: 16930560 TRAF6 and IRAK1 then dissociate from the receptor complex and interact with a membrane bound pre-associated complex of TGF-b activated kinase (TAK1) and two TAK1-binding proteins (TAB), termed TAB1 and TAB2

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977.0, 851.0
30.0, 30.0

p24

p24

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 16930560,11460167,11518704,12242293 Ubiquitination of TRAF6 and TAK1 activate the complex, and phosphorylation of TAK1 and TAB2 initiates the release of the complex from the membrane PMID: 16930560 A series of ubiquitination reactions then occur on TRAF6 itself and on its substrate TAK1.

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978.0, 936.0
27.0, 27.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 16930560,11518704,12242293 Phosphorylation of TAK1 and TAB2 occurs initiating the dissociation of TRAF6/TAK1/TAB1/TAB2 from the membrane to the cytosol, and IRAK-1 degradation PMID: 16930560,11460167,11518704,12242293 Ubiquitination of TRAF6 and TAK1 activate the complex, and phosphorylation of TAK1 and TAB2 initiates the release of the complex from the membrane

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588.0, 1054.0
23.0, 23.0

p14

p26

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e74 e91

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c112 : 1

m75*m92*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

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1102.0, 1092.0
27.0, 27.0

p27

p27

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e42 e25

e44 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c40 : 1
stoichiometry:c77 : 1
stoichiometry:c41 : 1

m43*m26*0.1

nodelay

--

true

0

false

PMID: 16930560,11518704,12242293 Phosphorylation of TAK1 and TAB2 occurs initiating the dissociation of TRAF6/TAK1/TAB1/TAB2 from the membrane to the cytosol, and IRAK-1 degradation PMID: 16930560,11460167,11518704,12242293 Ubiquitination of TRAF6 and TAK1 activate the complex, and phosphorylation of TAK1 and TAB2 initiates the release of the complex from the membrane

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852.0, 946.0
23.0, 23.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e43 MO000000248

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m44*m207*0.1

nodelay

--

true

0

false

PMID: 16930560,9346484 Active TAK1 phosphorylates the IKK complex, which in turn phosphorylates IkB targeting IkB for degradation PMID: 16930560 TAK1 is subsequently active and can then phosphorylate downstream targets such as the IkB kinases (IKKs).

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959.0, 217.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 16930560 TRIF binds to TLR3 and recruits TRAF6 directly through a TRAF6-binding motif in its N-terminal domain.

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709.0, 31.0
22.0, 22.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6*m11*0.1

nodelay

--

true

0

false

PMID: 16930560 The other antibacterial TLRs are TLR2, which in combination with TLR1 recognises triacylated lipopeptides, or in combination with TLR6 recognises diacylated lipopeptides; and TLR5 which recognises bacterial flagellin.

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739.0, 437.0
26.0, 26.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 MO000041437

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m183*m19305*0.1

nodelay

--

true

0

false

PMID: 16930560 TRIF binds to TLR3 and recruits TRAF6 directly through a TRAF6-binding motif in its N-terminal domain.

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780.0, 578.0
23.0, 23.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m63*m41*0.1

nodelay

--

true

0

false

PMID: 16930560,14530355,12609980,14982987 TRIF binds to TLR3 and recruits TRAF6 directly through a TRAF6-binding motif in its N-terminal domain. This leads to TAK1 activation and subsequent NFkB activation in an IRAK1 and IRAK4 independent manner

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791.0, 237.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000041437

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c90 : 1
stoichiometry:c92 : 1

m64*m19305*0.1

nodelay

--

true

0

false

PMID: 16930560,15064760 The C-terminal of TRIF possesses a RIP homotypic interaction motif (RHIM), and it associates with receptor interacting protein 1 (RIP1) through homophilic interaction of RHIM domains. PMID: 16930560,15064760 TRIF also binds directly to RIP1 which binds TRAF6 and leads to the activation of the IKK complex

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806.0, 348.0
27.0, 27.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m183*m65*0.1

nodelay

--

true

0

false

PMID: 16930560,15064760 TRIF also binds directly to RIP1 which binds TRAF6 and leads to the activation of the IKK complex

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667.0, 425.0
25.0, 25.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m66*m41*0.1

nodelay

--

true

0

false

PMID: 16930560,15064760 TRIF also binds directly to RIP1 which binds TRAF6 and leads to the activation of the IKK complex

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371.0, 437.0
25.0, 25.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000001935 e30

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m367*m31*0.1

nodelay

--

true

0

false

PMID: 16930560 Btk interacts with the TIR domain of TLR4 PMID: 16930560 More recently it has been found that Btk interacts with the TIR domains of many of the TLRs including that of TLR4 and also with Mal and MyD88, the adapters used by TLR4

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460.0, 322.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000022528

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m67*m6810*0.1

nodelay

--

true

0

false

PMID: 16930560 On TLR ligation, TLR4 dimers and TLR2 heterodimerised with TLR1 or TLR6 recruit Mal and MyD88 to their TIR domains, TLR7/8/9 recruit MyD88 alone.

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344.0, 642.0
23.0, 23.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 16930560 LPS induces tyrosine phosphorylation of Btk and activates its kinase activity.

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371.0, 753.0
25.0, 25.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 16930560,15081522,12724322,15849198,16439361 It has since been shown that Btk directly phosphorylates Mal and functions on the pathway from TLR4 to the phosphorylation of the p65 subunit of NFkB, promoting transactivation

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666.0, 904.0
27.0, 27.0

p39

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 16930560,10837071,9346484,9244310,9346485,9346241 Once activated the IKK complex induces phosphorylation and subsequent degradation of IkB, which leads to the translocation of NFkB culminating in NFkB activation and the expression of pro-inflammatory cytokines

Go back
179.0, 297.0
26.0, 26.0

p2

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 MO000019397

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c10 : 1
stoichiometry:c12 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 16930560 The other antibacterial TLRs are TLR2, which in combination with TLR1 recognises triacylated lipopeptides, or in combination with TLR6 recognises diacylated lipopeptides; and TLR5 which recognises bacterial flagellin.

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700.0, 1022.0
23.0, 23.0

p14

p40

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e91 e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m92*m77*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
800.0, 1110.0
23.0, 23.0

p41

p41

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e98 e10

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c161 : 1

m99*m10*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes

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804.0, 1206.0
23.0, 23.0

p41

p42

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e98 e99

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c182 : 1

m99*m100*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes

Go back
493.0, 1199.0
21.0, 21.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c123 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression PMID: 16930560 As NFkB is a key transcription factor regulating the expression of IL-1b and TNFa they examined the ability of LPS to induce expression of Rel-family proteins.

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581.0, 1207.0
21.0, 21.0

p43

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e75

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c124 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
641.0, 1131.0
21.0, 21.0

p43

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

G010229

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c125 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
353.0, 1315.0
21.0, 21.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c130 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression PMID:16930560,16166516,16166517 TNFa expression is induced in an NFkB-independent IRF3-dependent manner, binds to the TNF receptor and induces NFkB activation providing delayed NFkB induction

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421.0, 1347.0
21.0, 21.0

p46

p47

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c137 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
881.0, 1411.0
21.0, 21.0

p46

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010229

MO000017061

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m93218*0.1

nodelay

--

true

0

false

PMID: 16930560,8011280 Once activated by a PAMP, a TLR triggers a cascade of cellular signals, culminating in the eventual activationofNFkBwhichbinds to a discretenucleotide sequence in the upstream regions of genes that produce proinflammatory cytokines, such as TNFa, IL-1, and IL-2, thereby regulating their expression

Go back
324.0, 1118.0
23.0, 23.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e91

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c185 : 1
stoichiometry:c131 : 1

m93248*m92*0.1

nodelay

--

true

0

false

PMID: 16930560 At this point in time the ligands for TLRs were unknown and researchers only knew that by constitutively activating TLRs they could drive NFkB activation and cause the production of the proinflammatory cytokines TNFa, IL-1, IL-6 and IL-8.

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171.0, 345.0
26.0, 26.0

p2

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m13*m14*0.1

nodelay

--

true

0

false

PMID: 16930560 The other antibacterial TLRs are TLR2, which in combination with TLR1 recognises triacylated lipopeptides, or in combination with TLR6 recognises diacylated lipopeptides; and TLR5 which recognises bacterial flagellin.

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348.0, 1370.0
23.0, 23.0

p49

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e79 e91

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c186 : 1
stoichiometry:c135 : 1

m80*m92*0.1

nodelay

--

true

0

false

PMID: 16930560 At this point in time the ligands for TLRs were unknown and researchers only knew that by constitutively activating TLRs they could drive NFkB activation and cause the production of the proinflammatory cytokines TNFa, IL-1, IL-6 and IL-8.

Go back
196.0, 226.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c3 : 1
stoichiometry:c141 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 16930560 LPS was known to be concentrated from the plasma by LPS binding protein (LBP), and CD14 was identified as a receptor for LPS on the surface of the cells

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340.0, 254.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021929 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c2 : 1

m6255*m3961*0.1

nodelay

--

true

0

false

PMID: 16930560 The best characterised is TLR4, which recognises the Gram-negative product lipopolysaccharide (LPS).

Go back
752.0, 650.0
23.0, 23.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45 e24

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m46*m25*0.1

nodelay

--

true

0

false

PMID: 16930560,10837071,9346484,9244310,9346485,9346241 Once activated the IKK complex induces phosphorylation and subsequent degradation of IkB, which leads to the translocation of NFkB culminating in NFkB activation and the expression of pro-inflammatory cytokines

Go back
632.0, 714.0
23.0, 23.0

p54

p54

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e81

e70 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c147 : 1
stoichiometry:c149 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 16930560,10837071,9346484,9244310,9346485,9346241 Once activated the IKK complex induces phosphorylation and subsequent degradation of IkB, which leads to the translocation of NFkB culminating in NFkB activation and the expression of pro-inflammatory cytokines

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689.0, 1087.0
21.0, 21.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e83

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m5*m84*0.1

nodelay

--

true

0

false

PMID; 16930560,8258685 Soon afterwards it was reported that PTKs were required for the induction of the pro-inflammatory cytokines IL-1b, IL-6 and TNFa in response to LPS in murine macrophages

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525.0, 1243.0
21.0, 21.0

p55

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e83

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m5*m84*0.1

nodelay

--

true

0

false

PMID; 16930560,8258685 Soon afterwards it was reported that PTKs were required for the induction of the pro-inflammatory cytokines IL-1b, IL-6 and TNFa in response to LPS in murine macrophages

Go back
441.0, 1099.0
23.0, 23.0

p55

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e83

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m5*m84*0.1

nodelay

--

true

0

false

PMID; 16930560,8258685 Soon afterwards it was reported that PTKs were required for the induction of the pro-inflammatory cytokines IL-1b, IL-6 and TNFa in response to LPS in murine macrophages

Go back
729.0, 1067.0
21.0, 21.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e91

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c160 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 16930560 As NFkB is a key transcription factor regulating the expression of IL-1b and TNFa they examined the ability of LPS to induce expression of Rel-family proteins.

Go back
839.0, 41.0
26.0, 26.0

p2

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022185 MO000019399

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 16930560 The other antibacterial TLRs are TLR2, which in combination with TLR1 recognises triacylated lipopeptides, or in combination with TLR6 recognises diacylated lipopeptides; and TLR5 which recognises bacterial flagellin.

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169.0, 1331.0
21.0, 21.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m230*m86*0.1

nodelay

--

true

0

false

Go back
500.0, 1574.0
23.0, 23.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e80 e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m81*m88*0.1

nodelay

--

true

0

false

Go back
541.0, 839.0
21.0, 21.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e86 e70

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m87*m71*0.1

nodelay

--

true

0

false

PMID: 16930560 To date, five distinct serine residues have been identified on the p65 NFkB subunit that are inducibly phosphorylated in response to LPS, TNFa, and IL-1.

Go back
545.0, 911.0
21.0, 21.0

p62

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e88 e70

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m89*m71*0.1

nodelay

--

true

0

false

PMID: 16930560 To date, five distinct serine residues have been identified on the p65 NFkB subunit that are inducibly phosphorylated in response to LPS, TNFa, and IL-1.

Go back
609.0, 731.0
21.0, 21.0

p62

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e70 e89

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c36 : 1
stoichiometry:c178 : 1

m5*m71*m90*0.1

nodelay

--

true

0

false

PMID: 16930560 To date, five distinct serine residues have been identified on the p65 NFkB subunit that are inducibly phosphorylated in response to LPS, TNFa, and IL-1. PMID: 16930560,9660950,9150141 Serine 276 in the RHD on p65 is phosphorylated by protein kinase A (PKA) in response to LPS

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709.0, 735.0
21.0, 21.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017462 e84

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c114 : 1
stoichiometry:c181 : 1

m2282*m85*0.1

nodelay

--

true

0

false

PMID: 16930560,11931769,9660950 Zhong et al. found that LPS stimulated PKAdependent phosphorylation of p65 on serine 276 promotes its interaction with the coactivator CREB-binding protein (CBP), potentiating NFkB transcription

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859.0, 765.0
19.0, 19.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000210 MO000000211 MO000016599

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c133 : 1
stoichiometry:c136 : 1
stoichiometry:c159 : 1

m181*m182*m1593*0.1

nodelay

--

true

0

false

Go back
588.0, 482.0
23.0, 23.0

p67

p67

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 MO000000211 e70

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m5*m182*m71*0.1

nodelay

--

true

0

false

PMID: 16930560 They found that IKKb plays an essential role in LPS-induced serine 536 phosphorylation in MEFs,while IKKa is only partially required for serine 536 phosphorylation

Go back
608.0, 426.0
23.0, 23.0

p67

p68

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 MO000000210 e70

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m5*m181*m71*0.1

nodelay

--

true

0

false

PMID: 16930560 They found that IKKb plays an essential role in LPS-induced serine 536 phosphorylation in MEFs,while IKKa is only partially required for serine 536 phosphorylation

Go back
702.0, 1176.0
19.0, 19.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e91 e71

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m92*m72*0.1

nodelay

--

true

0

false

PMID: 16930560,11356851 A new nuclear IkB protein, IkBz, arrived on the scene relatively recently, which has been shown to interact with NFkB via a Cterminal ankyrin repeat domain in the nucleus

Go back
1152.0, 334.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16930560 The anti-viral TLRs are TLR3 which recognises double stranded RNA, TLR7 and TLR8 which bothrecognise single strandedRNA,andTLR9which recognises CpGmotifs, that exist in both virus and bacteria

Go back
745.0, 1059.0
21.0, 21.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 16930560 IkBz is barely detectable in resting cells but it is dramatically induced in response to TLR ligands such as LPS, lipopeptides and CpG DNA, in a MyD88 dependent manner.

Go back
721.0, 1143.0
21.0, 21.0

p71

p71

cso30:i:ME_Translation

cso30:i:CC_Nucleolus

--

e93

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 16930560 IkBz is barely detectable in resting cells but it is dramatically induced in response to TLR ligands such as LPS, lipopeptides and CpG DNA, in a MyD88 dependent manner.

Go back
470.0, 1144.0
19.0, 19.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e71

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m72*0.1

nodelay

--

true

0

false

PMID:16930560 IkBz is essential for the induction of a subset of inflammatory genes including IL-6 and the IL-12p40 subunit.

Go back
690.0, 1320.0
19.0, 19.0

p72

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e71

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m72*0.1

nodelay

--

true

0

false

PMID:16930560 IkBz is essential for the induction of a subset of inflammatory genes including IL-6 and the IL-12p40 subunit.

Go back
313.0, 1175.0
22.0, 22.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e71 e5

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c207 : 1

m93248*m72*m5*0.1

nodelay

--

true

0

false

PMID: 16930560,15618216 Interestingly overexpression of IkBz results in an augmentation of IL-6 production in response to LPS, but inhibits TNFa production

Go back
353.0, 1267.0
22.0, 22.0

p74

p75

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e71 e5

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c211 : 1

m93309*m5*0.1

nodelay

--

true

0

false

PMID: 16930560,15618216 Interestingly overexpression of IkBz results in an augmentation of IL-6 production in response to LPS, but inhibits TNFa production

Go back
734.0, 312.0
22.0, 22.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000019331

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m19305*m3902*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes PMID: 16930560,14530355 TRIF can also interact with TBK1/IKKe which leads to the activation of IRF3

Go back
737.0, 283.0
22.0, 22.0

p76

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000016608

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m19305*m1599*0.1

nodelay

--

true

0

false

PMID: 16930560,14530355 TRIF can also interact with TBK1/IKKe which leads to the activation of IRF3

Go back
741.0, 343.0
21.0, 21.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e94 MO000007694

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1

m95*m977*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes PMID: 16930560,14530355 TRIF can also interact with TBK1/IKKe which leads to the activation of IRF3

Go back
761.0, 383.0
21.0, 21.0

p78

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 MO000007694

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m96*m977*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes PMID: 16930560,14530355 TRIF can also interact with TBK1/IKKe which leads to the activation of IRF3

Go back
1048.0, 18.0
23.0, 23.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000042126

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m17*m19940*0.1

nodelay

--

true

0

false

PMID: 16930560 The anti-viral TLRs are TLR3 which recognises double stranded RNA, TLR7 and TLR8 which bothrecognise single strandedRNA,andTLR9which recognises CpGmotifs, that exist in both virus and bacteria

Go back
601.0, 379.0
22.0, 22.0

p80

p80

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes

Go back
589.0, 907.0
21.0, 21.0

p81

p81

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m98*0.1

nodelay

--

true

0

false

Go back
848.0, 1222.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e100

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes PMID:16930560,12471095 IFN inducible genes are induced via the activation of IRF3 and other interferon inducible factors. LPS induction of IFN-inducible genes encoding IP-10, GARG-16 and IRG-1 was comparable in wild type,Mal-deficient andMyD88-deficientmacrophages

Go back
756.0, 1354.0
23.0, 23.0

p83

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e102

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 16930560,14517278 TLR3 recruits TRIF to its TIR domain which interacts with TBK1 activating IRF3 which binds as a dimer to the ISRE site of the IFNb and IP-10 genes

Go back
455.0, 229.0
25.0, 25.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e5 MO000041132

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m5*m19005*0.1

nodelay

--

true

0

false

PMID: 16930560 TLR4 recruits TRAM to its TIR domain which in turn recruits TRIF and activates TBK1

Go back
579.0, 189.0
25.0, 25.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041125 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m18998*m104*0.1

nodelay

--

true

0

false

PMID: 16930560 TLR4 recruits TRAM to its TIR domain which in turn recruits TRIF and activates TBK1

Go back
681.0, 175.0
23.0, 23.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e105 e104

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c246 : 1
stoichiometry:c248 : 1

m106*m105*0.1

nodelay

--

true

0

false

PMID: 16930560 TLR4 recruits TRAM to its TIR domain which in turn recruits TRIF and activates TBK1

Go back
576.0, 298.0
20.0, 20.0

p88

p89

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000019331 MO000007694

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1
stoichiometry:c251 : 1

m3902*m977*0.1

nodelay

--

true

0

false

PMID: 16930560 TBK1 activates IRF3

Go back
1176.0, 38.0
23.0, 23.0

p7

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 MO000042007

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m17*m19823*0.1

nodelay

--

true

0

false

PMID: 16930560 The anti-viral TLRs are TLR3 which recognises double stranded RNA, TLR7 and TLR8 which bothrecognise single strandedRNA,andTLR9which recognises CpGmotifs, that exist in both virus and bacteria

Go back
777.0, 1031.0
21.0, 21.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e91 e98 e5 e107

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c257 : 1
stoichiometry:c258 : 1
stoichiometry:c254 : 1

m92*m99*m5*0.1

nodelay

--

true

0

false

PMID: 16930560 Under LPS stimulation p65 homodimers appear to interactwith IRF3 to activate the IP-10 gene PMID: 16930560,16143103 This IRF3/p65 complex is susceptible to glucocorticoid inhibition

Go back
901.0, 1203.0
21.0, 21.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e106

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 16930560 Under LPS stimulation p65 homodimers appear to interactwith IRF3 to activate the IP-10 gene

Go back
821.0, 1251.0
21.0, 21.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e98

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m99*0.1

nodelay

--

true

0

false

PMID:16930560,12471095 IFN inducible genes are induced via the activation of IRF3 and other interferon inducible factors. LPS induction of IFN-inducible genes encoding IP-10, GARG-16 and IRG-1 was comparable in wild type,Mal-deficient andMyD88-deficientmacrophages

Go back
781.0, 1243.0
21.0, 21.0

p92

p93

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e98

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m99*0.1

nodelay

--

true

0

false

PMID:16930560,12471095 IFN inducible genes are induced via the activation of IRF3 and other interferon inducible factors. LPS induction of IFN-inducible genes encoding IP-10, GARG-16 and IRG-1 was comparable in wild type,Mal-deficient andMyD88-deficientmacrophages

Go back
592.0, 1394.0
23.0, 23.0

p94

p94

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e110 e5

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c265 : 1
stoichiometry:c264 : 1

m111*m5*0.1

nodelay

--

true

0

false

PMID:16930560,10565609 Orlicek et al., directly implicated Src kinases in LPS signalling to TNFa and iNOS (inducible nitric oxide synthase) induction with the use of the Src-selective inhibitor PP1, in murine macrophages

Go back
465.0, 1295.0
21.0, 21.0

p94

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e110 e5

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c268 : 1
stoichiometry:c267 : 1

m111*m5*0.1

nodelay

--

true

0

false

PMID:16930560,10565609 Orlicek et al., directly implicated Src kinases in LPS signalling to TNFa and iNOS (inducible nitric oxide synthase) induction with the use of the Src-selective inhibitor PP1, in murine macrophages

Go back
533.0, 1159.0
21.0, 21.0

p96

p96

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e98

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m99*0.1

nodelay

--

true

0

false

PMID:16930560,16166516,16166517 TNFa expression is induced in an NFkB-independent IRF3-dependent manner, binds to the TNF receptor and induces NFkB activation providing delayed NFkB induction

Go back
372.0, 978.0
23.0, 23.0

p97

p97

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e70 e86

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m71*m87*0.1

nodelay

--

true

0

false

PMID:16930560,16166516,16166517 TNFa expression is induced in an NFkB-independent IRF3-dependent manner, binds to the TNF receptor and induces NFkB activation providing delayed NFkB induction

Go back
157.0, 210.42781352708207

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.3503890106016, 127.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.9930645847388, 331.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 133.9700770964848

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.7560686275974, 416.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.4043537592802, 126.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.2379768964621, 462.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 668.9425724154552

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.66665368506426, 665.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 770.6867029780244

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
279.5412876511472, 775.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.7401771901032, 832.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.9849956845465, 329.93684433976614

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.3379865726819, 931.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.0, 598.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 1077.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 994.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 763.6645789750689

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.0, 1038.9990241521741

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.7781291679853, 1045.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.892222835927, 716.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.7280011169603, 1072.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0, 1140.7267426978774

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.0, 323.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 1101.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
593.8231932086841, 1149.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.0076972702698, 1104.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.93280328948975, 1204.034713472542

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.1990703441655, 1228.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.1492607094655, 1152.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0561610125072, 1213.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.8093669577919, 1315.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.0, 1319.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.3954559836462, 1430.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.89654651623377, 377.98691099462604

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
200.7378477230355, 1283.0311850272967

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
210.65032158554615, 1134.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.72030587361115, 1135.09687320024

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.7055704106664, 761.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.7666645192148, 1271.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
227.97569713079395, 1383.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.0, 742.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.5536045447851, 1368.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
127.0, 190.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
185.0, 141.5536014515662

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.44262295081967, 378.8688524590164

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.0, 134.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 249.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.0, 269.18672362344194

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 283.1620321884467

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 680.9949028347804

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.0, 610.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 662.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.0, 737.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.5777087639997, 674.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 719.6643638388299

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
189.0, 371.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.0, 177.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
658.8041362749238, 1108.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.1760968779618, 1106.5360477369666

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
258.0, 177.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.1185397025019, 1211.6505331807703

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.9911218293119, 1254.3767915990245

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
257.0, 177.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.7187130424239, 1116.102728933723

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.24, 1122.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.9241117830363, 784.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.7181105699019, 42.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.9484768506501, 1088.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.0, 1131.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.7339445046937, 1074.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 1219.796029752168

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
180.0, 1291.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
197.99001871102277, 1339.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
189.0, 1263.091450586585

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 1582.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 1523.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 1521.56951030983

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.2018798841383, 69.05338360929788

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.0, 866.4484305027331

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.6304752485329, 807.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 852.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.2201001377728, 939.9969716724115

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.2073680319214, 814.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 885.6665457376292

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 173.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.5173231066631, 753.639450347116

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 752.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 166.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 60.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.833070699734, 749.6257316546618

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 754.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.298985563638, 1229.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.1554175279993, 995.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
372.37457089344144, 1001.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.0, 997.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.2666237010624, 507.97286913052045

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.5540051095983, 512.5813625358603

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.268036862948, 294.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 505.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 163.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.7462736935531, 454.565998440422

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.7988760535901, 456.795129565557

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.0, 449.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.0, 1001.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.3370149585768, 1201.722373185794

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.6281649995302, 1195.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.0, 354.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
758.0, 1080.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.3363843680743, 173.96011760590113

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1062.0, 299.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.9975603804354, 1123.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.0, 1164.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.44298117871006, 1160.932921951462

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.945204834583, 1155.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.6568542494924, 1272.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.5439226686631, 1334.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.7851360534159, 1161.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
210.96714565174162, 1175.7242859683402

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.8706614022529, 1189.4327208699137

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
254.0, 177.0

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.3900308614855, 357.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
379.54913349652696, 1213.0

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
201.0, 1278.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.99803810692777, 1266.0

c212

c212

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
254.0, 177.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.9002382780819, 288.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.0, 316.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 323.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.9938556058523, 286.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 271.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 297.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 36.871832634470955

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.96546479532, 331.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.0, 340.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.63194973521, 357.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.9839800083988, 375.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.0, 343.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.9510698773889, 383.8834522085988

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.906973581205, 384.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.7907296779343, 392.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 416.0

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
610.0, 923.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 48.788930484542405

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.9531617649475, 1172.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
860.0, 1245.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.2039430457753, 1320.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.9917483216824, 1367.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 41.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 159.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.9650738084743, 235.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.73451162270106, 127.57811585117288

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.9649902509884, 203.74761641345017

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 114.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.1289833923401, 115.63009583781735

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 109.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.9501595910173, 188.89160668310473

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.0, 198.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.9915578396218, 309.3674279466493

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1009.0, 50.335035147949455

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.1901475651512, 316.5073890561713

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
596.0, 318.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 993.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.7681190314781, 1045.9121523769793

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
798.0, 1050.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 1141.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.68253731564, 1224.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 174.0

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
797.3645433680812, 1055.2262880622263

c258

c258

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
835.5944732131918, 1074.0

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1163.0, 68.22288415059144

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 1272.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0613893640746, 1074.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
742.6800773412384, 1264.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.9981103105913, 1406.1738719632738

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
563.4560373723303, 1389.8995700892397

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.0, 177.0

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.8335437553216, 1309.6234507179038

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.90833988522166, 1220.4526209558805

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 177.0

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
561.5968096732819, 1065.0

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1181.399500935551, 61.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.6576914183889, 1173.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.8948707674254, 811.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 1008.2142583013871

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.0, 949.6733147681016

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1271.4452121626266, 413.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.0, 450.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.0, 238.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1197.5775375331502, 482.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.82842712474621, 124.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 542.2829318197008

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.0, 535.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 608.3954710098458

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 530.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.4179508858714, 567.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 911.7122191220958

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.1554175279994, 1016.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.51068238804, 1057.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 55.181810036201874

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.0, 1110.4832628735826

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.310492388962, 1067.2491077284276

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.6115561484353, 993.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 1034.7759056409234

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.56892908110547, 73.84464540552736

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.0, 66.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.0, 121.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
570.906973581205, 268.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 334.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0777552946205, 114.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.7620869714772, 56.803528016541655

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
388.9911682507319, 510.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.8539409299159, 714.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 778.2549247428507

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 667.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.00116841387637, 774.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.0, 855.5760542672981

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.64088049225796, 850.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.79505959393884, 1029.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.0, 879.9711254108329

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.65269068981644, 906.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 48.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 469.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 818.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 775.6039472493969

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1007.2402547094721, 583.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.3490666988755, 620.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 666.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 673.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 710.9464590424101

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.9999965804907, 690.0073967653235

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.0, 703.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.0, 60.75211628261636

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.8750245902755, 841.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.0, 871.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.8738952378426, 925.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 955.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 1071.0613012044826

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1122.2987830845307, 1032.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.6257316546618, 1001.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 1119.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.5795107684525, 970.550828281513

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
844.0, 923.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 42.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.3068575400565, 919.2572738431577

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.7134717977852, 245.0859104712841

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.0, 228.2855322440993

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.0, 238.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.0, 450.13791053800674

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.4543476044101, 295.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.0, 450.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
809.8253803366036, 465.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.543497616308, 602.6024600970973

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
797.0, 601.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 50.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.8278328271655, 253.65076746695325

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 243.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 258.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.0, 368.1637266682634

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.8680491917036, 365.4469975524972

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 367.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.9936076697743, 426.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0564491633347, 453.2267985930149

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 450.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.86587642053087, 280.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back