1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/16979566.csml convertedTime:2009.07.01.10:57

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Fifty years of interferon research: aiming at a moving target.
Authors Vilcek J.
Affiliation Department of Microbiology, New York University School of Medicine, New York,New York 10016, USA. jan.vilcek@med.nyu.edu
Abstract Nearly half a century has passed since the first published description ofinterferons (IFNs). This commentary introduces the four accompanying reviewarticles on type I IFN research and attempts to relate how the field of IFNresearch has been changing during its history.
PMID 16979566
Model Abstract

Entity

G010199:OAS G010262:IL-6 G010329:TNF-alpha G010453:IFN-gamma G010657:IL-12 p40 MO000007685:IRF-1 MO000007690:IRF-2 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016656:STATs MO000016658:IFN Type I MO000016664:IFN Type II MO000016665:IFNgamma MO000016882:LPS MO000019394:TLR4 MO000019398:TLR3 MO000022224:dsRNA MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000103999:MDA-5 e1: e10: e11:IFNGR 1: IFNGR 2 e12:IFN Type II: IFNGR 1: IFNGR 2 e13:Jak e14:Jak{activated} e15:STATs{activated} e16:phytohemagglutinin e17:IFN e18:poly I: C e19:IFN e2: e20:PKR{activated} e21:PKR e22:OAS e23:OAS{activated} e24:RIG1 e25:dsRNA: RIG1 e26:dsRNA: MDA-5 e27:ssRNA e28:pathogenic DNA e29:pathogenic DNA: TLR9 e3: e30:ssRNA: TLR7 e31:ssRNA: TLR8 e32:IFN Type I e33:IFN Type I e34:LPS: TLR4 e35:ligand: TLR e36:IRF-5{activated} e37:MyD88{activated} e4: e5:Type I IFN receptor dimer e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFN Type I: Type I IFN receptor dimer e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p4 p5 p6 p7 p8 p9
Model Detail
456.0, 732.0
31.0, 31.0

OAS

--

G010199

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m93189

10

false

infinite

0

unit false false false
TRANSFACG010199

--

Go back
482.0, 650.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
622.0, 730.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
432.0, 848.0
31.5, 31.5

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
597.0, 685.0
30.0, 30.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p31

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
412.0, 176.0
32.5, 32.5

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
474.0, 178.0
28.0, 28.0

IRF-2

--

MO000007690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m974

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007690

--

Go back
563.0, 939.0
33.0, 33.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
636.0, 268.0
32.0, 32.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
617.0, 917.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
321.0, 462.0
31.0, 31.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
641.0, 177.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
478.0, 238.0
27.0, 27.0

STATs

--

MO000016656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m1633

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
217.0, 26.0
30.0, 30.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
105.0, 213.0
30.0, 30.0

IFN Type II

--

MO000016664

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1638

10

false

infinite

0

unit false false false
TRANSPATHMO000016664

--

Go back
314.0, 903.0
28.0, 28.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
896.0, 580.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
807.0, 579.0
32.0, 32.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
218.0, 325.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
137.0, 581.0
29.0, 29.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
212.0, 367.0
31.0, 31.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
810.0, 330.0
26.0, 26.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
813.0, 413.0
28.0, 28.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
809.0, 247.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
432.0, 364.0
31.0, 31.0

MDA-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
211.61592740722355, 110.338222234131
639.8509771416207, 929.063618809632

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
259.0461469408243, 223.8462175465799
546.2982503969581, 768.4880276699222

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
211.625, 204.5
25.228753541076482, 30.892351274787533

IFNGR 1: IFNGR 2

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
214.875, 269.5
27.0338135437695, 37.72160029363186

IFN Type II: IFNGR 1: IFNGR 2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
350.5, 180.125
34.857114107466295, 21.49522036627088

Jak

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
349.5, 243.125
37.924129603541964, 23.386546588850877

Jak{activated}

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

p3 p4

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
477.0, 285.0
29.0, 29.0

STATs{activated}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000016656

--

Go back
152.125, 844.5
23.483346749849066, 38.08110283759308

phytohemagglutinin

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
297.5, 693.125
37.69470718454418, 23.245069430468906

IFN

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
141.5, 803.25
45.0, 25.5

poly I: C

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
401.5, 804.0
45.0, 24.0

IFN

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p7 p8

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
211.61592740722355, 110.338222234131
639.8509771416207, 929.063618809632

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
325.0, 504.0
31.0, 31.0

PKR{activated}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

--

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
464.5, 697.0
39.965397923875436, 21.314878892733564

PKR

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p10

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
325.5, 544.125
36.028375930770785, 22.217498490641983

OAS

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
325.5, 580.125
34.410344133628506, 21.219712215737577

OAS{activated}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
314.375, 326.5
27.445079086115992, 42.2231985940246

RIG1

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
368.375, 361.5
23.25, 45.0

dsRNA: RIG1

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
434.625, 413.5
36.75, 45.0

dsRNA: MDA-5

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
940.5, 330.625
45.0, 24.75

ssRNA

--

e27

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p16 p17

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
912.5, 411.125
45.0, 15.75

pathogenic DNA

--

e28

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p18

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
811.625, 452.5
30.617855357440423, 37.49125145809032

pathogenic DNA: TLR9

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
224.41294695005593, 123.13524177696343
614.256938055956, 903.4695797239674

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
808.625, 285.5
28.60102482919513, 35.02166305615731

ssRNA: TLR7

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
809.625, 370.5
26.78832694550908, 32.80203299450091

ssRNA: TLR8

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
765.0, 781.0
30.0, 30.0

IFN Type I

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19 p20 p21 p23

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
613.5, 782.0
37.110726643598625, 19.792387543252595

IFN Type I

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
808.625, 637.5
29.148100316613892, 35.69155140809865

LPS: TLR4

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
577.625, 114.5
28.437718713547742, 34.821696383936015

ligand: TLR

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p29

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
640.0, 324.0
32.0, 32.0

IRF-5{activated}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
645.0, 225.0
30.0, 30.0

MyD88{activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
248.08743310429588, 145.53002597692006
566.907965747476, 858.6800113240537

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
303.5, 115.0
33.64922512914515, 41.20313281119814

Type I IFN receptor dimer

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
363.3544587907576, 633.5111373391744
315.05654760987437, 285.7216735307424

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
397.3829127225503, 640.2823256278747
184.22300921694696, 276.921211307003

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
367.4613411618362, 637.3246709694613
306.8427828677176, 278.09460627016813

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
368.04803864341864, 637.9113684510439
305.6693879045521, 276.921211307003

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
363.3544587907576, 633.5111373391744
315.05654760987437, 285.7216735307424

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
363.3544587907576, 633.5111373391744
315.05654760987437, 285.7216735307424

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
368.04803864341864, 637.9113684510439
305.6693879045521, 276.921211307003

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
593.3398715711496, 750.850633655701
19.683002015180605, 17.818296561110863

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
541.710493191878, 832.9882810772698
55.736260750350176, 50.455983416106506

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
363.3544587907576, 633.5111373391744
315.05654760987437, 285.7216735307424

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
214.5, 138.0
34.92714259497155, 48.735547806937056

IFN Type I: Type I IFN receptor dimer

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
437.611514361229, 760.483488118612
9.977377935835639, 4.803922709846791

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
437.27834147016915, 746.1570538030401
34.15022133363063, 61.4703984005351

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
451.60477578574154, 786.1378007302178
5.330766256956971, 5.330766256956972

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
252.0207722257702, 112.63129955016632
552.713240160256, 783.1803845813221

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
220.99539751071592, 127.4536765447867
530.2243972897843, 769.8858248647665

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
226.261064937238, 141.27605353940714
527.8036320698382, 759.7889651875971

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
220.0, 79.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m1634*m5*0.1

nodelay

--

true

0

false

PMID: 16979566, 16979568 It is now clear that all type I IFNs bind to the same dimeric receptor, but different type I IFNs elicit somewhat different biological responses. PMID: 16979566, 6175095 By the early 1980s, binding studies with radiolabeled IFN proteins had led to the conclusion that there are specific high-affinity cell-surface receptors for IFNs, that different subspecies of type I IFN (IFN-¦Á and IFN-beta) share a common receptor, and that receptors for type I and type II IFN are distinct.

Go back
407.0, 695.0
25.0, 25.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 16979566, 4366491, 1067606 Two of the IFN-induced proteins central to IFN's antiviral actions, 2¡ì-5¡ì oligoadenylate synthetase and double-stranded RNA-dependent protein kinase (PKR), were shown to require double-stranded RNA for their activation.

Go back
400.0, 733.0
24.0, 24.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 16979566, 4366491, 1067606 Two of the IFN-induced proteins central to IFN's antiviral actions, 2¡ì-5¡ì oligoadenylate synthetase and double-stranded RNA-dependent protein kinase (PKR), were shown to require double-stranded RNA for their activation.

Go back
256.0, 543.0
25.0, 25.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m22*m119368*0.1

nodelay

--

true

0

false

PMID: 16979566, 4366491, 1067606 Two of the IFN-induced proteins central to IFN's antiviral actions, 2¡ì-5¡ì oligoadenylate synthetase and double-stranded RNA-dependent protein kinase (PKR), were shown to require double-stranded RNA for their activation.

Go back
138.0, 369.0
27.0, 27.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 16979566, 11607032 Molecular pathways mediating cellular responses to double-stranded RNA remained largely unknown until the demonstration that toll-like receptor 3 (TLR3) recognizes double-stranded RNA. PMID: 16979566, 16979569 As explained in more detail in the accompanying review, this cytosolic pathway is functional mainly in specialized cells, namely dendritic cells (DCs).

Go back
263.0, 371.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m119368*m24*0.1

nodelay

--

true

0

false

PMID: 16979566, 16625202, 15208624 It is now apparent that the main pathway of type I IFN induction by double-stranded RNA and various RNA-containing viruses, which can be activated in a variety of cell types, is triggered by the cytosolic caspase-recruitment domain (CARD)-containing helicases RIG-I or MDA5.

Go back
369.0, 424.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 16979566, 16625202, 15208624 It is now apparent that the main pathway of type I IFN induction by double-stranded RNA and various RNA-containing viruses, which can be activated in a variety of cell types, is triggered by the cytosolic caspase-recruitment domain (CARD)-containing helicases RIG-I or MDA5.

Go back
882.0, 290.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m19940*m27*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
883.0, 375.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m19823*m27*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
922.0, 458.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m19828*m28*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
687.0, 743.0
27.0, 27.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c58 : 1
stoichiometry:c55 : 1

m30*m33*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
107.0, 275.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1638*m11*0.1

nodelay

--

true

0

false

PMID: 16979566, 6175095 By the early 1980s, binding studies with radiolabeled IFN proteins had led to the conclusion that there are specific high-affinity cell-surface receptors for IFNs, that different subspecies of type I IFN (IFN-¦Á and IFN-beta) share a common receptor, and that receptors for type I and type II IFN are distinct.

Go back
706.0, 782.0
27.0, 27.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c59 : 1
stoichiometry:c56 : 1

m31*m33*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
723.0, 831.0
25.0, 25.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c60 : 1
stoichiometry:c57 : 1

m29*m33*0.1

nodelay

--

true

0

false

PMID: 16979566 In addition to double-stranded RNA, other microbial components or products have been shown to trigger type I IFN production through other pathways, including single-stranded viral RNA (acting on TLR7 and TLR8) and viral or bacterial DNA (via TLR9).

Go back
900.0, 640.0
27.0, 27.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 16979566, 16410796, 16979569 Although nucleic acids are arguably the most important activators of type I IFN production, bacterial LPS is now known to trigger IFN production in macrophages and DCs via TLR4.

Go back
731.0, 683.0
25.0, 25.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m33*m34*0.1

nodelay

--

true

0

false

PMID: 16979566, 16410796, 16979569 Although nucleic acids are arguably the most important activators of type I IFN production, bacterial LPS is now known to trigger IFN production in macrophages and DCs via TLR4.

Go back
413.0, 53.0
30.0, 30.0

p24

p24

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1

m970*0.1

nodelay

--

true

0

false

PMID: 16979566, 11244049 The earliest-discovered members of this family, IRF-1 and IRF-2, were shown to be important in a variety of innate and adaptive immune responses, including T helper 1 responses and natural killer (NK) cell differentiation.

Go back
472.0, 52.0
31.0, 31.0

p25

p25

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1

m974*0.1

nodelay

--

true

0

false

PMID: 16979566, 11244049 The earliest-discovered members of this family, IRF-1 and IRF-2, were shown to be important in a variety of innate and adaptive immune responses, including T helper 1 responses and natural killer (NK) cell differentiation.

Go back
568.0, 828.0
24.0, 24.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 16979566, 9707562, 9822609 Two other members of the IRF family, IRF-3 and IRF-7, have been found to play key roles in type I IFN gene activation.

Go back
620.0, 828.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m980*0.1

nodelay

--

true

0

false

PMID: 16979566, 9707562, 9822609 Two other members of the IRF family, IRF-3 and IRF-7, have been found to play key roles in type I IFN gene activation.

Go back
578.0, 270.0
27.0, 27.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c78 : 1
stoichiometry:c74 : 1

m979*m37*0.1

nodelay

--

true

0

false

PMID: 16979566, 15665823 For example, MyD88-dependent activation of IRF-5 is essential for the TLR-mediated induction of the proinflammatory cytokines TNF-alpha, IL-6, and IL-12, but not for IFN-alpha and IFN-beta induction.

Go back
579.0, 227.0
26.0, 26.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m1572*m35*0.1

nodelay

--

true

0

false

PMID: 16979566, 15665823 For example, MyD88-dependent activation of IRF-5 is essential for the TLR-mediated induction of the proinflammatory cytokines TNF-alpha, IL-6, and IL-12, but not for IFN-alpha and IFN-beta induction.

Go back
289.0, 177.0
30.0, 30.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c11 : 1
stoichiometry:c8 : 1

m13*m6*0.1

nodelay

--

true

0

false

PMID: 16979566, 8197455 Gradual elucidation of the details of the JAK-STAT signaling pathway activated by IFNs helped to clarify not only the molecular mechanisms responsible for IFN actions, but also laid the groundwork for understanding the actions of many other cytokines.

Go back
530.0, 650.0
27.0, 27.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c79 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16979566, 15665823 For example, MyD88-dependent activation of IRF-5 is essential for the TLR-mediated induction of the proinflammatory cytokines TNF-alpha, IL-6, and IL-12, but not for IFN-alpha and IFN-beta induction.

Go back
547.0, 687.0
25.0, 25.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c80 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16979566, 15665823 For example, MyD88-dependent activation of IRF-5 is essential for the TLR-mediated induction of the proinflammatory cytokines TNF-alpha, IL-6, and IL-12, but not for IFN-alpha and IFN-beta induction.

Go back
567.0, 731.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c81 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 16979566, 15665823 For example, MyD88-dependent activation of IRF-5 is essential for the TLR-mediated induction of the proinflammatory cytokines TNF-alpha, IL-6, and IL-12, but not for IFN-alpha and IFN-beta induction.

Go back
289.0, 237.0
30.0, 30.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c12 : 1
stoichiometry:c10 : 1

m13*m12*0.1

nodelay

--

true

0

false

PMID: 16979566, 8197455 Gradual elucidation of the details of the JAK-STAT signaling pathway activated by IFNs helped to clarify not only the molecular mechanisms responsible for IFN actions, but also laid the groundwork for understanding the actions of many other cytokines.

Go back
421.0, 240.0
29.0, 29.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m1633*0.1

nodelay

--

true

0

false

PMID: 16979566, 8197455 Gradual elucidation of the details of the JAK-STAT signaling pathway activated by IFNs helped to clarify not only the molecular mechanisms responsible for IFN actions, but also laid the groundwork for understanding the actions of many other cytokines.

Go back
313.0, 850.0
29.0, 29.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m93423*m16*0.1

nodelay

--

true

0

false

PMID: 16979566, 17838106 IFN-gamma owes its discovery to the finding that the addition of phytohemagglutinin, a mitogenic lectin, to a suspension of human leucocytes elicited IFN production.

Go back
300.0, 743.0
27.0, 27.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c23 : 1
stoichiometry:c20 : 1

m119368*m19*0.1

nodelay

--

true

0

false

PMID: 16979566, 5233831 Double-stranded RNA from statolon or helenine, and also synthetic double-stranded RNA, poly (I).poly(C), readily triggered IFN production in intact animals or in cell cultures.

Go back
301.0, 802.0
25.0, 25.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e18 e19

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18*m19*0.1

nodelay

--

true

0

false

PMID: 16979566, 5233831 Double-stranded RNA from statolon or helenine, and also synthetic double-stranded RNA, poly (I).poly(C), readily triggered IFN production in intact animals or in cell cultures.

Go back
254.0, 463.0
29.0, 29.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m1055*m119368*0.1

nodelay

--

true

0

false

PMID: 16979566, 4366491, 1067606 Two of the IFN-induced proteins central to IFN's antiviral actions, 2¡ì-5¡ì oligoadenylate synthetase and double-stranded RNA-dependent protein kinase (PKR), were shown to require double-stranded RNA for their activation.

Go back
232.0, 56.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.0, 253.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.0, 169.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
242.0, 262.39152084838906

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.0, 255.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.9949028347804, 253.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 266.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 879.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
349.99950621855953, 864.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
176.0, 864.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
151.79349009962777, 610.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
250.13188148017372, 100.6243987850063

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.0, 723.9945186701341

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.0, 815.0701727388662

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.9993075691336, 815.1052540469623

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
334.05882352941177, 767.7647058823529

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
291.0, 478.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 486.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 478.1700470910188

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 706.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 713.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
432.0, 708.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
232.0, 102.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 746.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.99802542265286, 555.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 562.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 556.00813909547

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
152.0, 404.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.0, 383.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.01809793534807, 347.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
153.0, 391.663061386377

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 436.0068115224166

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.57753753315023, 357.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
120.0, 243.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 384.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.09551454207565, 393.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 436.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 268.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.8599434057004, 314.1159660434202

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 303.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.0, 351.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.6833366579515, 355.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 387.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 433.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.7075489304051, 228.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 427.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.0, 471.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.6860080409401, 303.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.746162468035, 384.07021100168265

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.8387389501, 471.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.0, 764.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0, 796.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 816.9463531699773

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 767.734068956465

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
651.0, 793.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
132.0, 288.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.0, 801.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 610.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 605.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.998959620257, 654.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 708.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.1283159748743, 663.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 712.2235169765557

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.0, 91.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
488.0, 91.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 860.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.99609660869663, 191.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 807.4513482233507

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 859.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 810.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 284.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 295.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.4, 203.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 240.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 149.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.7075489304051, 250.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.0, 664.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 207.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 700.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 744.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.7995998288793, 340.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
560.0854274898487, 343.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.854476744262, 350.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.8076214712466, 202.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back