1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17056121.csml convertedTime:2009.07.01.10:58

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Shaping of monocyte and macrophage function by adenosine receptors.
Authors Hasko G, Pacher P, Deitch EA, Vizi ES.
Affiliation Department of Surgery, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.haskoge@umdnj.edu
Abstract Adenosine is an endogenous purine nucleoside that, following its release intothe extracellular space, binds to specific adenosine receptors expressed on thecell surface. Adenosine appears in the extracellular space under metabolicallystressful conditions, which are associated with ischemia, inflammation, and celldamage. There are 4 types of adenosine receptors (A(1), A(2A), A(2B) and A(3))and all adenosine receptors are members of the G protein-coupled family ofreceptors. Adenosine receptors are expressed on monocytes and macrophages andthrough these receptors adenosine modulates monocyte and macrophage function.Since monocytes and macrophages are activated by the same danger signals thatcause accumulation of extracellular adenosine, adenosine receptors expressed onmacrophages represent a sensor system that provide monocytes and macrophageswith information about the stressful environment. Adenosine receptors, thus,allow monocytes and macrophages to fine-tune their responses to stressfulstimuli. Here, we review the consequences of adenosine receptor activation onmonocyte/macrophage function. We will detail the effect of stimulating thevarious adenosine receptor subtypes on macrophage differentiation/proliferation,phagocytosis, and tissue factor (TF) expression. We will also summarize ourknowledge of how adenosine impacts the production of extracellular mediatorssecreted by monocytes and macrophages in response to toll-like receptor (TLR)ligands and other inflammatory stimuli. Specifically, we will delineate howadenosine affects the production of superoxide, nitric oxide (NO), tumornecrosis factor-alpha, interleukin (IL)-12, IL-10, and vascular endothelialgrowth factor (VEGF). A deeper insight into the regulation of monocyte andmacrophage function by adenosine receptors should assist in developing newtherapies for inflammatory diseases.
PMID 17056121
Model Abstract

Entity

G010329:TNF-alpha G010514:iNOS G010657:IL-12 p40 G011282:CDKN1B MO000000030:PI3K MO000000048:AKT MO000000214:IL-1 MO000000289:TNF-alpha MO000014520:VEGF MO000016882:LPS MO000017089:adenosine MO000017247:IL-10 MO000017265:IL-12 MO000019394:TLR4 MO000021201:iNOS MO000038797:L-arginine MO000101316:inosine MO000101324:uric acid e1: e10: e11:adenosine kinase e12:adenosine e13:nucleoside transporter e14:ATP e15:ADP e16:ADP e17:AMP e18:AMP e19:CD39 e2: e20:CD73 e21:adenosine deaminase e22:A1 e23:adenosine: A1 e24:A2A e25:adenosine: A2A e26:A2B e27:adenosine:A2B e28:A3 e29:adenosine:A3 e3: e30:PKA e31:PKA{active} e32:Fc receptor e33:IgG e34:IgG:Fc receptor e35:adenosine receptor e36:NECA:adenosine receptor e37:NECA e38:A1:CPA e39:CPA e4: e40:H2O2 e41:fLMP e42:IFN-gamma e43:nitric oxide e44:CCPA e45:CCPA:A1 e46:CGS 21680 e47:CGS 21680:A2A e48:VEGF e49:LPS:TLR4 e5:ATP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:5¡ì-nucleotidase e60: e61: e62: e63:IL-12p40 e64:IB-MECA e65:IB-MECA:A3 e66:PI3K{active} e67:AKT{active} e68:IL-12 e69:IL-10 e7: e70:Adenylate cyclase{active} e71:Adenylate cyclase e72:cAMP e73:dilazep e74:dilazep:A2A e75:TF e76:TF e77:R-PIA e78:CHA e79:2-CADO e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p7 p8 p9
Model Detail
816.0, 1424.0
32.0, 32.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
747.0, 1275.0
34.0, 34.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27 p28 p29

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
994.0, 1426.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
1061.0, 1257.0
38.0, 38.0

CDKN1B

--

G011282

cso30:c:mRNA

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m94167

10

false

infinite

0

unit false false false
TRANSFACG011282

--

Go back
859.0, 595.0
34.0, 34.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
895.0, 803.0
34.0, 34.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
239.0, 1227.0
34.0, 34.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
247.0, 1083.0
34.0, 34.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1305.0, 1349.0
38.0, 38.0

VEGF

--

MO000014520

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m1553

10

false

infinite

0

unit false false false
TRANSPATHMO000014520

--

Go back
1072.0, 32.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p24 p26 p35

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1156.0, 368.0
32.0, 32.0

adenosine

--

MO000017089

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m114924

10

false

infinite

0

unit false false false
TRANSPATHMO000017089

--

Go back
212.0, 1476.0
32.0, 32.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1532.0, 1472.0
40.0, 40.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1102.0, 178.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
760.0, 764.0
32.0, 32.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p32

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
482.0, 688.0
30.0, 30.0

L-arginine

--

MO000038797

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p32

true true true true

csml-variable:Double

m16983

10

false

infinite

0

unit false false false
DIP232
TRANSPATHMO000038797

--

Go back
1156.0, 580.0
32.0, 32.0

inosine

--

MO000101316

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m74305

10

false

infinite

0

unit false false false
TRANSPATHMO000101316

--

Go back
1204.0, 680.0
24.0, 24.0

uric acid

--

MO000101324

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m74313

10

false

infinite

0

unit false false false
Affymetrix1175
TRANSPATHMO000101324

--

Go back
332.9991960963385, 156.49832641497844
1154.2791008740974, 1611.6744090581897

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
344.12059486344737, 181.1320234805156
1118.8499195740123, 1513.4880369895739

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1070.0, 283.1
35.199999999999996, 26.399999999999995

adenosine kinase

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1600.0, 368.0
32.0, 32.0

adenosine

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000017089

--

Go back
1445.0, 254.6155285313377
22.266604303086993, 51.384471468662305

nucleoside transporter

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
851.0, 104.65547024952015
41.53550863723608, 22.844529750479847

ATP

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p4

p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
728.0, 364.75335892514386
39.53934740882917, 21.746641074856047

ADP

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
728.0, 100.75335892514386
39.53934740882917, 21.746641074856047

ADP

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p5

p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
611.0, 134.51919385796555
34.510556621880994, 18.980806142034552

AMP

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
611.0, 362.51919385796555
34.510556621880994, 18.980806142034552

AMP

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
984.5, 36.553632521634086
23.70859327832562, 38.446367478365865

CD39

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p8

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
332.9991960963385, 156.49832641497844
1154.2791008740974, 1611.6744090581897

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
494.0, 61.85594013096353
19.12909260991581, 44.14405986903648

CD73

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1268.0, 485.22
39.03999999999999, 29.28

adenosine deaminase

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1436.5, 412.688927943761
30.75219683655536, 47.31107205623901

A1

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p23 p30

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1441.5, 487.5748739311555
21.402981802236347, 41.42512606884455

adenosine: A1

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1437.5, 549.219683655536
29.107205623901578, 44.78031634446397

A2A

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13 p31 p58

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1440.5, 621.7465468099102
22.86428414821311, 44.2534531900899

adenosine: A2A

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1435.5, 681.5307557117751
24.35500878734622, 37.46924428822496

A2B

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1444.5, 761.3126507344881
23.605130453847842, 45.687349265511955

adenosine:A2B

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1441.5, 813.1142355008787
29.17574692442882, 44.885764499121265

A3

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p41

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1440.5, 877.996491997369
22.73514580135935, 44.00350800263101

adenosine:A3

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
356.08477811382045, 178.69769844057348
1108.1079368391336, 1567.275665007001

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1305.0, 643.2712815715622
21.54911131898971, 49.72871842843779

PKA

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1306.0, 816.8634237605238
19.99251637043966, 46.136576239476135

PKA{active}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1424.5, 955.2829525483305
31.666080843585238, 48.7170474516696

Fc receptor

--

e32

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1656.0, 1022.6923076923077
31.538461538461544, 47.30769230769231

IgG

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1430.5, 1026.4716071037055
26.106336329752246, 50.52839289629467

IgG:Fc receptor

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1329.5, 173.09490333919155
29.838312829525485, 45.90509666080843

adenosine receptor

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1403.5, 171.82657311992983
25.406270554702914, 49.17342688007016

NECA:adenosine receptor

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1466.0, 59.0
60.0, 34.0

NECA

--

e37

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p21 p38

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1426.5, 332.95921946941456
27.921069940802454, 54.0407805305854

A1:CPA

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1650.0, 263.0
60.0, 34.0

CPA

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
398.79310484616224, 217.54659948536454
1022.6912833744506, 1489.5778629174172

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
218.0, 514.5294117647059
44.117647058823536, 26.47058823529412

H2O2

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
259.0, 381.50462573591255
50.28595458368376, 28.495374264087467

fLMP

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
144.0, 1312.4736379613355
47.732864674868196, 31.026362038664328

IFN-gamma

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p29 p32

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
506.0, 849.9411764705882
46.76470588235295, 28.058823529411764

nitric oxide

--

e43

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p26 p32

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1710.0, 451.0
60.0, 34.0

CCPA

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p30

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1430.5, 1102.4716071037053
26.10633632975225, 50.528392896294676

CCPA:A1

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1730.0, 747.0
60.0, 34.0

CGS 21680

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p31

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1430.5, 1173.3144047358037
27.737557553168166, 53.68559526419645

CGS 21680:A2A

--

e47

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
856.0, 1347.6989619377164
47.43944636678201, 25.301038062283737

VEGF

--

e48

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1146.5, 170.55053716290297
26.065555799166845, 50.44946283709714

LPS:TLR4

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
871.0, 363.9587332053744
42.80230326295585, 23.541266794625724

ATP

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
577.3329568888857, 1085.9490164201297
627.7188030599204, 547.4187575836428

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
645.131263364631, 1098.9220451531655
367.04600402386444, 530.5578102248035

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
585.5155111187175, 1093.2554269422933
611.3536946002582, 532.8059365393151

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
586.6844474372646, 1094.3794900995495
609.0158219631634, 530.5578102248035

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
577.3329568888857, 1085.9490164201297
627.7188030599204, 547.4187575836428

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
577.3329568888857, 1085.9490164201297
627.7188030599204, 547.4187575836428

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
586.6844474372646, 1094.3794900995495
609.0158219631634, 530.5578102248035

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1035.555993759441, 1310.7616478713164
39.216421811663146, 34.1383614522708

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
932.6895977272768, 1468.1304898871492
111.04895026199712, 96.66943152401086

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
577.3329568888857, 1085.9490164201297
627.7188030599204, 547.4187575836428

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
996.0, 460.1808210907627
39.43650633930368, 24.31917890923727

5¡ì-nucleotidase

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
725.2827468395128, 1329.217388931868
19.87893215701232, 9.203912915865036

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
724.6189330258508, 1301.76914261327
68.04091590034975, 117.77212664607983

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
753.1629270133153, 1378.368899781452
10.621021018591176, 10.21330095575759

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1532.0, 1425.3035822097002
47.34554236264842, 29.19641779029986

IL-12p40

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1765.0, 948.7317073170731
53.41463414634146, 30.26829268292683

IB-MECA

--

e64

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1427.5, 1244.0103047577288
24.27800920850691, 46.98969524227144

IB-MECA:A3

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
831.0, 719.0
34.0, 34.0

PI3K{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
843.0, 935.0
34.0, 34.0

AKT{active}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
890.0, 1476.0
60.0, 32.0

IL-12

--

e68

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
690.0, 1478.6297577854673
55.069204152249135, 29.370242214532873

IL-10

--

e69

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
348.16473986966906, 162.98383164505074
1131.9881838381182, 1542.423694566449

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
568.5, 1041.3022740994165
23.246930972026565, 37.69772590058362

Adenylate cyclase{active}

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
495.5, 920.2978466492252
24.482994566311127, 39.702153350774815

Adenylate cyclase

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
675.5, 527.1160852986867
41.185849456291486, 41.88391470131337

cAMP

--

e72

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1826.0, 1087.0
60.0, 34.0

dilazep

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1431.5, 1312.6551194913397
24.461521596141196, 47.34488050866038

dilazep:A2A

--

e74

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
886.0, 1567.1557093425606
54.083044982698965, 28.844290657439448

TF

--

e75

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1291.0, 1587.5800000000002
42.559999999999995, 31.920000000000005

TF

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p60 p62

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1302.0, 1815.0
60.0, 34.0

R-PIA

--

e77

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
974.0, 1799.0
60.0, 34.0

CHA

--

e78

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
618.0, 1807.0
60.0, 34.0

2-CADO

--

e79

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
352.2088848758903, 190.20611939824832
1085.9297532671674, 1516.240909196248

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
362.9932715591477, 217.4284071514456
1080.971888273685, 1496.3557896077348

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1003.0, 351.0
17.0, 17.0

p1

p1

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c9 : 1
stoichiometry:c2 : 1

m114924*m11*0.1

nodelay

--

true

0

false

PMID: 17056121, 11111829 Under hypoxic conditions, the increased intracellular dephosphorylation of adenosine 5¡ì-triphosphate (ATP) to adenosine by the metabolic enzyme 5¡ì-nucleotidase is accompanied by a suppression of the activity of the salvage enzyme adenosine kinase, which prevents the rephosphorylation of adenosine.

Go back
1162.0, 489.5
20.5, 20.5

p10

p10

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m114924*m21*0.1

nodelay

--

true

0

false

PMID: 17056121, 10623851, 2581508, 11223861, 15019271 Adenosine accumulation is limited by its catabolism to inosine by adenosine deaminase. Inosine is finally degraded to the stable end product uric acid.

Go back
1137.0, 681.0
21.0, 21.0

p11

p11

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m74305*0.1

nodelay

--

true

0

false

PMID: 17056121, 10623851, 2581508, 11223861, 15019271 Adenosine accumulation is limited by its catabolism to inosine by adenosine deaminase. Inosine is finally degraded to the stable end product uric acid.

Go back
1538.0, 426.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m22*m12*0.1

nodelay

--

true

0

false

PMID: 17056121 Lower concentrations of adenosine activate the high affinity A1, A2A, and A3 receptors, and high adenosine concentrations stimulate the low affinity A2B receptors.

Go back
1526.0, 562.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m24*m12*0.1

nodelay

--

true

0

false

PMID: 17056121 Lower concentrations of adenosine activate the high affinity A1, A2A, and A3 receptors, and high adenosine concentrations stimulate the low affinity A2B receptors.

Go back
1604.0, 688.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m26*m12*0.1

nodelay

--

true

0

false

PMID: 17056121 Lower concentrations of adenosine activate the high affinity A1, A2A, and A3 receptors, and high adenosine concentrations stimulate the low affinity A2B receptors.

Go back
1544.0, 824.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m28*m12*0.1

nodelay

--

true

0

false

PMID: 17056121 Lower concentrations of adenosine activate the high affinity A1, A2A, and A3 receptors, and high adenosine concentrations stimulate the low affinity A2B receptors.

Go back
1270.0, 90.0
19.0, 19.0

p16

p16

cso30:i:CE_CellDifferentiation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17056121, 956374 The first evidence supporting the concept that endogenous adenosine is capable of preventing human monocyte maturation was provided by demonstrating that adenosine deaminase activity is increased during early monocyte differentiation and that adenosine deaminase inhibition during this period delayed the maturation process. PMID: 17056121, 2159513 High concentrations of exogenous adenosine seem to prevent monocyte development into macrophages and arrest monocyte development at a stage with high accessory function, a phenotype that is similar to dendritic cells.

Go back
1306.0, 738.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m30*m27*0.1

nodelay

--

true

0

false

PMID: 17056121 The mechanism of action of adenosine involves induction, in a PKA-dependent manner, of the expression of p27kip-1, a cyclin-dependent kinase inhibitor that leads to growth arrest at the G1 phase of the cell cycle.

Go back
1292.0, 1268.0
23.0, 23.0

p18

p18

cso30:i:CE_G1Arrest

cso30:i:CC_Extracellular

--

G011282

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1

m94167*0.1

nodelay

--

true

0

false

PMID: 17056121 The mechanism of action of adenosine involves induction, in a PKA-dependent manner, of the expression of p27kip-1, a cyclin-dependent kinase inhibitor that leads to growth arrest at the G1 phase of the cell cycle.

Go back
1101.0, 1185.0
21.0, 21.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17056121 The mechanism of action of adenosine involves induction, in a PKA-dependent manner, of the expression of p27kip-1, a cyclin-dependent kinase inhibitor that leads to growth arrest at the G1 phase of the cell cycle.

Go back
1006.0, 385.5
20.5, 20.5

p2

p2

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c5 : 1
stoichiometry:c4 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 17056121, 11111829 Under hypoxic conditions, the increased intracellular dephosphorylation of adenosine 5¡ì-triphosphate (ATP) to adenosine by the metabolic enzyme 5¡ì-nucleotidase is accompanied by a suppression of the activity of the salvage enzyme adenosine kinase, which prevents the rephosphorylation of adenosine.

Go back
1520.0, 976.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 17056121, 15466916 When a small particle is coated (opsonized) with IgG, the Fc regions of the IgG antibody molecules bind to Fc receptors that are expressed on the macrophage plasma membrane and trigger a phagocytic response.

Go back
1406.0, 106.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m35*m37*0.1

nodelay

--

true

0

false

PMID: 17056121 In human monocytes, the non-selective adenosine receptor agonist 5¡ì-N-ethylcarboxamidoadenosine (NECA) but not 2-p-(2-carboxyethyl)phenethylamino-5¡ì-N-ethyl-carboxamidoadenosine (CGS 21680), a selective agonist of A2A receptors, down-regulated the proliferation of human peripheral blood mononuclear cells obtained from healthy subjects.

Go back
1579.0, 183.0
25.0, 25.0

p22

p22

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e36 e38

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c61 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17056121 In human monocytes, the non-selective adenosine receptor agonist 5¡ì-N-ethylcarboxamidoadenosine (NECA) but not 2-p-(2-carboxyethyl)phenethylamino-5¡ì-N-ethyl-carboxamidoadenosine (CGS 21680), a selective agonist of A2A receptors, down-regulated the proliferation of human peripheral blood mononuclear cells obtained from healthy subjects. PMID: 17056121, 10725262 On the other hand, the selective A1 receptor agonist N6-cyclopentyladenosine (CPA), but not other agonists, inhibited the proliferation of mononuclear cells in asthmatic patients.

Go back
1564.0, 304.0
23.0, 23.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m22*m39*0.1

nodelay

--

true

0

false

Go back
517.0, 517.0
21.0, 21.0

p24

p24

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c62 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17056121, 10496321, 14977938 Two later studies, one using fMLP and the other LPS to stimulate oxidative burst, confirmed that the effect of adenosine could be attributed primarily to A3 receptor stimulation.

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484.0, 580.0
23.0, 23.0

p25

p25

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c65 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17056121, 10496321, 14977938 Two later studies, one using fMLP and the other LPS to stimulate oxidative burst, confirmed that the effect of adenosine could be attributed primarily to A3 receptor stimulation.

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591.0, 767.0
25.0, 25.0

p26

p26

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c77 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c70 : 1

m16983*m5576*m155666*0.1

nodelay

--

true

0

false

PMID: 17056121, 8619882 Nitric oxide (NO) synthases (NOS) catalyze the oxidation of one of the guanidino nitrogens of l-arginine to the reactive nitrogen species NO. PMID: 17056121 Of the several NOS isoforms that can catalyze NO synthesis, iNOS is the primary one that is responsible for antimicrobial activity by producing high levels of NO. PMID: 17056121, 8906843 We demonstrated that both the selective A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and A2A agonist CGS 21680 suppressed NO production by LPS-stimulated RAW264.7 macrophages, both with low efficacy.

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752.0, 1176.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 17056121, 1711326 Host expression of iNOS is first and foremost regulated at the transcriptional level and can be stimulated in response to microbial products or by cytokines such as IL-1, tumor necrosis factor-¦Á (TNF-¦Á) and interferon-¦Ã (IFN-¦Ã)

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651.0, 1231.0
26.0, 26.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 17056121, 1711326 Host expression of iNOS is first and foremost regulated at the transcriptional level and can be stimulated in response to microbial products or by cytokines such as IL-1, tumor necrosis factor-¦Á (TNF-¦Á) and interferon-¦Ã (IFN-¦Ã)

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644.0, 1320.0
23.0, 23.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c86 : 1
stoichiometry:c75 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17056121, 1711326 Host expression of iNOS is first and foremost regulated at the transcriptional level and can be stimulated in response to microbial products or by cytokines such as IL-1, tumor necrosis factor-¦Á (TNF-¦Á) and interferon-¦Ã (IFN-¦Ã) PMID: 17056121, 10092821, 10510349 treatment of IFN-¦Ã-activated bone marrow macrophages with NECA decreased both iNOS induction and NO production in these cells.

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1335.0, 375.0
17.0, 17.0

p3

p3

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c8 : 1
stoichiometry:c7 : 1

m114924*m13*0.1

nodelay

--

true

0

false

PMID: 17056121, 11396612, 11396615 These processes lead to adenosine reaching high concentrations inside the cell and the release of adenosine into the extracellular space through nucleoside transporters.

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1700.0, 548.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m22*m44*0.1

nodelay

--

true

0

false

Go back
1660.0, 832.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m46*m24*0.1

nodelay

--

true

0

false

PMID: 17056121, 8906843 We demonstrated that both the selective A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and A2A agonist CGS 21680 suppressed NO production by LPS-stimulated RAW264.7 macrophages, both with low efficacy.

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478.0, 802.0
19.0, 19.0

p32

p32

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c88 : 1

m16983*m5576*m42*0.1

nodelay

--

true

0

false

PMID: 17056121, 10092821, 10510349 treatment of IFN-¦Ã-activated bone marrow macrophages with NECA decreased both iNOS induction and NO production in these cells.

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828.0, 1212.0
23.0, 23.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c103 : 1
stoichiometry:c92 : 1

m25*m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 7945378 Stimulation of A2 receptors in U-937 human macrophages elicits VEGF mRNA accumulation. PMID: 17056121, 12057925 A2A receptor stimulation and LPS through TLR4 activation synergistically facilitated the production of VEGF.

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928.0, 1192.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17056121, 7945378 Stimulation of A2 receptors in U-937 human macrophages elicits VEGF mRNA accumulation.

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1137.0, 86.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17056121, 12057925 A2A receptor stimulation and LPS through TLR4 activation synergistically facilitated the production of VEGF.

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1220.0, 1348.0
23.0, 23.0

p36

p36

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c100 : 1

m48*m25*m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 12057925 A2A receptor stimulation and LPS through TLR4 activation synergistically facilitated the production of VEGF.

Go back
516.0, 1416.0
23.0, 23.0

p37

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c140 : 1
stoichiometry:c105 : 1

m93309*m49*0.1

nodelay

--

true

0

false

PMID: 17056121 Adenosine is a strong inhibitor of TNF-¦Á production by monocytes and macrophages. PMID: 17056121 IL-10 was also described as cytokine synthesis inhibitory factor, because IL-10 can inhibit the secretion of a variety of proinflammatory cytokines, including TNF-¦Á and IL-12

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815.0, 1351.0
25.0, 25.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c194 : 1
stoichiometry:c104 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17056121 Adenosine is a strong inhibitor of TNF-¦Á production by monocytes and macrophages. PMID: 17056121, 12875990 The inhibitory effect of adenosine on TNF-¦Á production by macrophages is not limited to TLR4-mediated (LPS) induction of this cytokine because adenosine down-regulates TNF-¦Á production when induced by agonists of TLR2, TLR3, TLR4, TLR7 and TLR9. PMID: 17056121 adenosine receptor agonists were shown to suppress TNF-¦Á production by LPS (TLR4 ligand)-challenged human monocytes with the following rank order of potency: NECA > R-PIA = CGS 21680 > 2-CADO (2-chloroadenosine) = CHA (N6-cyclohexyladenosine). PMID: 17056121, 11023991 In addition, CGS 21680 potently decreased TNF-¦Á production by A2A WT macrophages but it failed to influence TNF-¦Á release by KO cells.

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971.0, 1347.0
25.0, 25.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c117 : 1
stoichiometry:c138 : 1
stoichiometry:c111 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 11023991 Using A2A receptor knockout mice, our group documented that adenosine down-regulates IL-12 p40 production by LPS-stimulated mouse peritoneal macrophages and that this effect is dependent, in part, on A2A receptors. PMID: 17056121 Further evidence implicating A2A receptors came from studies with human monocytes, in which CGS 21680 potently blunted LPS-induced IL-12 (both IL-12p40 and IL-12) production, which effect was reversed by A2A antagonists.

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863.0, 270.5
18.5, 18.5

p4

p4

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c30 : 1
stoichiometry:c11 : 1

m5*m155666*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase). PMID: 17056121, 9759915 bacterial lipopolysaccharide (LPS) augmented the release of ATP from macrophages.

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1255.0, 1467.0
25.0, 25.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c136 : 1
stoichiometry:c112 : 1

m93589*m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 11023991 Using A2A receptor knockout mice, our group documented that adenosine down-regulates IL-12 p40 production by LPS-stimulated mouse peritoneal macrophages and that this effect is dependent, in part, on A2A receptors. PMID: 17056121 Further evidence implicating A2A receptors came from studies with human monocytes, in which CGS 21680 potently blunted LPS-induced IL-12 (both IL-12p40 and IL-12) production, which effect was reversed by A2A antagonists.

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1591.0, 891.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m28*m64*0.1

nodelay

--

true

0

false

PMID: 17056121, 9822893 A3 receptor stimulation can also negatively regulate IL-12 production, because the selective A3 receptor agonist IB-MECA moderates IL-12 production both in LPS-treated mice. PMID: 17056121, 16116186 IB-MECA activated the phosophatidyl inositol-3-kinase (PI3K) pathway, and the activity of both PI3K and Akt was required for its suppressive effect

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805.0, 665.0
21.0, 21.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m66*m65*0.1

nodelay

--

true

0

false

PMID: 17056121, 9822893 A3 receptor stimulation can also negatively regulate IL-12 production, because the selective A3 receptor agonist IB-MECA moderates IL-12 production both in LPS-treated mice. PMID: 17056121, 16116186 IB-MECA activated the phosophatidyl inositol-3-kinase (PI3K) pathway, and the activity of both PI3K and Akt was required for its suppressive effect.

Go back
903.0, 883.0
17.0, 17.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c126 : 1
stoichiometry:c125 : 1

m68*m67*0.1

nodelay

--

true

0

false

PMID: 17056121, 9822893 A3 receptor stimulation can also negatively regulate IL-12 production, because the selective A3 receptor agonist IB-MECA moderates IL-12 production both in LPS-treated mice. PMID: 17056121, 16116186 IB-MECA activated the phosophatidyl inositol-3-kinase (PI3K) pathway, and the activity of both PI3K and Akt was required for its suppressive effect.

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925.0, 1389.0
21.0, 21.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c135 : 1
stoichiometry:c139 : 1
stoichiometry:c127 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 9822893 A3 receptor stimulation can also negatively regulate IL-12 production, because the selective A3 receptor agonist IB-MECA moderates IL-12 production both in LPS-treated mice. PMID: 17056121, 16116186 IB-MECA activated the phosophatidyl inositol-3-kinase (PI3K) pathway, and the activity of both PI3K and Akt was required for its suppressive effect. PMID: 17056121 Further evidence implicating A2A receptors came from studies with human monocytes, in which CGS 21680 potently blunted LPS-induced IL-12 (both IL-12p40 and IL-12) production, which effect was reversed by A2A antagonists.

Go back
1341.0, 1525.0
21.0, 21.0

p45

p45

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c137 : 1
stoichiometry:c141 : 1
stoichiometry:c128 : 1

m70*m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 9822893 A3 receptor stimulation can also negatively regulate IL-12 production, because the selective A3 receptor agonist IB-MECA moderates IL-12 production both in LPS-treated mice. PMID: 17056121 Further evidence implicating A2A receptors came from studies with human monocytes, in which CGS 21680 potently blunted LPS-induced IL-12 (both IL-12p40 and IL-12) production, which effect was reversed by A2A antagonists. PMID: 17056121 IL-10 was also described as cytokine synthesis inhibitory factor, because IL-10 can inhibit the secretion of a variety of proinflammatory cytokines, including TNF-¦Á and IL-12

Go back
710.0, 1374.0
19.0, 19.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c142 : 1

m49*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-PIA

Go back
477.0, 1541.0
21.0, 21.0

p47

p47

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c144 : 1

m71*m49*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-P

Go back
665.0, 1401.0
21.0, 21.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c161 : 1
stoichiometry:c149 : 1

m230*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-PIA.

Go back
534.0, 1610.0
19.0, 19.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c153 : 1
stoichiometry:c160 : 1
stoichiometry:c151 : 1

m71*m230*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-PIA.

Go back
736.0, 288.0
23.0, 23.0

p5

p5

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase).

Go back
788.0, 1540.0
23.0, 23.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c154 : 1

m40*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-PIA.

Go back
429.0, 1469.0
22.0, 22.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c162 : 1
stoichiometry:c156 : 1

m71*m40*m12*0.1

nodelay

--

true

0

false

PMID: 17056121, 8666814 In human monocytes activated with TNF-¦Á, H2O2, or LPS, adenosine up-regulated IL-10 production, an effect that was not mimicked by administering NECA, 2-CADO, or R-PIA.

Go back
571.0, 971.0
17.0, 17.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m73*m47*0.1

nodelay

--

true

0

false

PMID: 17056121 A2A receptor activation stimulates adenylate cyclase (AC) leading to elevated intracellular cAMP levels.

Go back
757.0, 449.0
22.0, 22.0

p53

p53

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c166 : 1

m5*m72*0.1

nodelay

--

true

0

false

PMID: 17056121 A2A receptor activation stimulates adenylate cyclase (AC) leading to elevated intracellular cAMP levels.

Go back
778.0, 1386.0
19.0, 19.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17056121 A2A receptor activation augments IL-10 production by monocytes and macrophages through a cyclic adenosine monophosphate (cAMP)-mediated pathway

Go back
620.0, 1600.0
23.0, 23.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c199 : 1
stoichiometry:c172 : 1

m71*m74*m25*0.1

nodelay

--

true

0

false

PMID: 17056121 A2A receptor activation augments IL-10 production by monocytes and macrophages through a cyclic adenosine monophosphate (cAMP)-mediated pathway.

Go back
727.0, 1551.0
25.0, 25.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c174 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17056121 A2B receptor activation also facilitates IL-10 production

Go back
742.0, 1702.0
19.0, 19.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c178 : 1
stoichiometry:c176 : 1

m71*m27*0.1

nodelay

--

true

0

false

PMID: 17056121 A2B receptor activation also facilitates IL-10 production

Go back
1660.0, 1140.0
23.0, 23.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m75*m24*0.1

nodelay

--

true

0

false

PMID: 17056121, 9310485, 15226179 In addition to its direct effects on platelets that are mediated via binding to A2A receptors, dilazep was reported to also block TF expression on monocytes and thereby inhibit blood coagulation.

Go back
1025.0, 1517.0
21.0, 21.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c182 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17056121, 9310485, 15226179 In addition to its direct effects on platelets that are mediated via binding to A2A receptors, dilazep was reported to also block TF expression on monocytes and thereby inhibit blood coagulation.

Go back
617.0, 297.0
21.0, 21.0

p6

p6

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase).

Go back
1161.0, 1589.0
30.0, 30.0

p60

p60

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17056121, 9310485, 15226179 In addition to its direct effects on platelets that are mediated via binding to A2A receptors, dilazep was reported to also block TF expression on monocytes and thereby inhibit blood coagulation.

Go back
998.0, 1498.0
19.0, 19.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c193 : 1
stoichiometry:c187 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 12152652 Adenosine inhibits TF expression on LPS-stimulated human monocytes through the activation of A3 receptors, because IB-MECA is the most potent agonist in reducing TF expression and the mixed A1/A3 antagonist XAC, but not selective A1, A2A, or A2B antagonists prevented the effect of adenosine.

Go back
1160.0, 1520.0
23.0, 23.0

p62

p62

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c188 : 1

m77*m49*0.1

nodelay

--

true

0

false

PMID: 17056121, 12152652 Adenosine inhibits TF expression on LPS-stimulated human monocytes through the activation of A3 receptors, because IB-MECA is the most potent agonist in reducing TF expression and the mixed A1/A3 antagonist XAC, but not selective A1, A2A, or A2B antagonists prevented the effect of adenosine.

Go back
863.0, 23.0
18.0, 18.0

p7

p7

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c20 : 1
stoichiometry:c17 : 1

m14*m19*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase).

Go back
738.0, 38.5
19.5, 19.5

p8

p8

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c21 : 1
stoichiometry:c19 : 1

m16*m19*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase).

Go back
1085.0, 133.0
21.0, 21.0

p9

p9

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m17*m20*0.1

nodelay

--

true

0

false

PMID: 17056121, 8955160, 9553767, 10470068, 15319286, 15583013, 16697102 The other major pathway that contributes to high extracellular adenosine concentrations during metabolic stress is release of precursor adenine nucleotides (ATP, ADP and AMP) from the cell. This is followed by extracellular degradation to adenosine by a cascade of ectonucleotidases, which include CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase]) and CD73 (5¡ì-ectonucleotidase).

Go back
1027.906300298589, 362.2208257813998

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.6691077741641, 296.82394269139445

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1243.0, 1361.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1238.3440160867583, 666.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1162.0, 221.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.3743456438051, 221.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
829.0, 1376.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
283.0077320641168, 1123.2387995298789

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.9936995359255, 1428.3174393317515

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.1860735027693, 221.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.6513796643885, 221.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.5071643540758, 400.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
872.0, 136.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.8863102439813, 399.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
988.0, 1372.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1280.0, 1444.1005469701975

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1022.0, 1442.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
987.1942807336707, 221.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1162.0, 221.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1271.8584236087293, 666.0

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
995.1893924510608, 662.0

c117

c117

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1471.0, 843.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1623.6294347953835, 910.40660023747

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 319.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1454.2903109354806, 916.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.4929882637098, 629.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 686.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.8043267563438, 690.5054328536085

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 837.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.2063309876478, 900.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 753.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
924.3151918984429, 1410.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1362.0, 1497.7451677096565

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.0, 1495.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 130.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
939.461295509957, 221.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1164.0, 221.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
863.0, 969.0

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
874.0, 969.0

c133

c133

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
859.0, 753.0

c134

c134

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
850.0, 753.0

c135

c135

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1278.1323475877175, 1221.0

c136

c136

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1356.0612275135543, 1227.0

c137

c137

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
999.778806799858, 1205.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
949.7217921494558, 1205.0

c139

c139

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
628.0, 326.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 1431.834187044391

c140

c140

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
244.0, 1493.0

c141

c141

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
718.1859962219901, 1393.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.75154753838103, 1500.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.80073383644026, 1497.7744158512076

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.7783029308426, 221.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.5559764012246, 221.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
734.3395416104586, 400.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.5577451736085, 400.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 1422.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.0, 162.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.464060241731, 1508.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.41006085515437, 1501.0151282100283

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 1113.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0, 1117.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.5098677696539, 1512.6499055497527

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
458.99154019698085, 1481.3678114735012

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.98833818622006, 1481.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 541.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
247.0, 541.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
812.5838379826473, 400.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 49.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.2403951835678, 400.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
691.3975109520372, 400.0

c161

c161

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.8519976217151, 399.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 947.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 988.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.7518572797068, 983.9770454509335

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.0779153868801, 471.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.6243829314532, 388.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0, 478.6324966904178

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0, 569.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.2656337673725, 36.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.6582157581511, 1405.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.6632630036138, 1508.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.67264556528752, 1499.2650629195396

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.4802187967516, 569.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.3151160102105, 1515.6576914183888

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 1508.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.37670271940243, 1502.095845117179

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.4135746386023, 797.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
764.8349373659668, 799.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1690.744948883107, 1112.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.0, 66.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1460.0, 594.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1462.2350053664502, 1162.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.3351878107351, 1533.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 1584.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1191.0, 1604.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.8343013053466, 1349.0

c185

c185

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1049.6216103537947, 1342.0

c186

c186

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
938.3302800111373, 1516.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.0, 1538.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 1535.534598364116

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
646.2283059911256, 56.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.9210081899172, 221.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1160.0, 221.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1185.8516097774525, 1280.0

c192

c192

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1020.4978327544934, 1275.0

c193

c193

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
843.8659151468242, 1204.0

c194

c194

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
836.8406094126403, 93.0

c195

c195

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
842.9316144921016, 1377.72132990828

c196

c196

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
834.4459549999139, 1379.729505883924

c197

c197

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
655.0, 1379.7268816013589

c198

c198

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
647.1747925254726, 658.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.9282586084793, 361.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.8560515758452, 35.51077914920099

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.9950365468204, 48.28176340253112

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
646.0, 144.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.0, 149.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 85.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1172.0, 400.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 510.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1191.0, 500.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1152.9137853216664, 612.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.0, 692.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
914.0, 379.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.4403474707883, 64.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1467.0, 436.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1563.3464746087222, 396.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1469.4102417766217, 444.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1467.0, 572.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1543.1348965210016, 400.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1469.1218086994556, 581.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1460.0, 700.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1616.0, 400.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1475.0703033307766, 706.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 385.6183000602123

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1471.0, 836.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1469.8074888811523, 843.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1559.0475069540362, 400.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.0, 112.73634885974211

c43

c43

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1292.0591345764822, 110.57714874288847

c44

c44

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1316.0, 693.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1316.0, 757.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1332.7457145573728, 752.0009762606546

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1090.9207002305477, 1206.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.9782234947224, 857.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1016.0, 414.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1099.0, 1276.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1456.0, 981.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1550.409587158603, 996.0162921176614

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1463.4610074998332, 997.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.0, 130.9244824410953

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1416.0, 125.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1432.1203469188692, 91.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1429.0, 196.0

c57

c57

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1467.0, 332.5378014698349

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1461.623406240106, 320.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1188.0, 384.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1594.5527339886228, 290.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1454.0, 210.9235061290585

c61

c61

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
270.0, 528.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.0780682402606, 62.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.711350239231, 533.4919381360364

c64

c64

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
269.7652376690292, 535.923820143228

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.0, 410.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.80836871084153, 597.2232447679362

c67

c67

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
512.0, 714.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 780.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1352.0, 384.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.3403601260162, 792.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 1199.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 1103.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 1250.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 1244.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 1300.808987532707

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
192.0, 1328.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.4068699806959, 64.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1467.0, 443.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1718.3099343641636, 485.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1357.8421713081511, 290.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1459.418834516352, 571.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1688.9056790631412, 781.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1467.0, 590.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1462.316570952875, 855.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.5785865136245, 787.7870978049634

c84

c84

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
619.6964539974967, 786.528472389149

c85

c85

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
666.2257369273124, 215.0

c86

c86

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
489.6643638388299, 718.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.0, 821.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.95180454635886, 782.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1026.1651621784847, 310.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
178.0, 827.8018259287886

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.33271665126586, 204.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
843.0, 1235.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.8073628169741, 655.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.8643041984317, 1215.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.2050680527689, 793.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1104.0, 61.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.0, 114.7003235347597

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0, 107.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1360.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back