_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e12
_enti_e59
_enti_e53
_enti_e13
_enti_e14
_enti_e51
_enti_e56
_enti_e50
_enti_e52
_enti_e54
_enti_e61
_enti_e57
_enti_e58
_enti_e60
_enti_e62
g2_fact_g2
g1_fact_g14
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g3
p1_propro_p1
PMID: 17273997
These results demonstrate that TLR induce IFN-alpha or IFN-beta responses by activating distinct IRF, depending on the TLR ligand and the cell type.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c167 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c11 cso30:c:InputProcess connector
c168 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17273997
MyD88 also recruits IRF-5 and triggers a TRAF6 signaling pathway that leads to activation of NF-kappaB.
c10 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c15 cso30:c:InputAssociation connector
c16 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17273997
The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.
c20 cso30:c:InputProcess connector
p8_propro_p8
PMID: 17273997
The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
PMID: 17273997
Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).
c24 cso30:c:InputAssociation connector
c22 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
PMID: 17273997
Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).
c25 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
PMID: 17273997
Both NF-kappaB and IRF-5 induce transcription of pro-inflammatory cytokine genes (TNF-alpha, IL-6, IL-12p40).
c26 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c31 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c32 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17273997
MyD88 recruits various signaling molecules, such as IRAK4 (IL-1R-associated kinase 4), IRAK1 and TRAF6 (TNFR-associated factor 6), which leads to activation and nuclear translocation of the transcription factor NF-kappaB that induces pro-inflammatory cytokine genes.
c33 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c40 cso30:c:InputProcess connector
c42 cso30:c:InputProcess connector
c41 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c46 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c47 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
PMID: 17273997, 16932750
It has previously been shown that phosphorylation is a critical event in IRF activation.
c61 cso30:c:InputAssociation connector
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
PMID: 17273997, 16932750
It has previously been shown that phosphorylation is a critical event in IRF activation.
c64 cso30:c:InputProcess connector
c60 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17273997
The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.
PMID: 17273997
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17273997
The simultaneous activation and subsequent nuclear translocation of IRF and NF-kappaB allows all these transcription factors to bind at the same time to certain gene promoters, providing a tremendous enhancement of gene induction.
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c68 cso30:c:InputProcess connector
c69 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17273997
In mDC, macrophages and other cells, TLR-3 and TLR-4 trigger a TRIF->TRAF3->TBK->IKKepsilon->IRF-3->IFN-beta pathway.
PMID: 17273997
IRF-3 is a transcription factor that induces the IFN-beta gene and other genes, such as, IP-10 (IFN-gamma-induced protein-10.
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c71 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17273997
IRF-3 is a transcription factor that induces the IFN-beta gene and other genes, such as, IP-10 (IFN-gamma-induced protein-10.
c73 cso30:c:InputAssociation connector
c72 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 17273997
In pDC, CpG-A trigger a TLR-9MyD88TRAF3IRF-7IFN-alpha/beta pathway.
c74 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 17273997, 17273999
In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway.
c77 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c79 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 17273997
In pDC, CpG-A trigger a TLR-9MyD88TRAF3IRF-7IFN-alpha/beta pathway.
c80 cso30:c:InputProcess connector
c83 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 17273997, 17273999
In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway.
c81 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17273997
In fact, the authors demonstrate that this pathway requires IRF-1, which is recruited and activated by MyD88.
PMID: 17273997, 17018642
The study by Negishi et al. [6] demonstrates that IRF-1 interacts with the middle region of MyD88, overlapping with the region interacting with IRF-5 and IRF-4, but distinct from that binding IRF-7.
c86 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c87 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17273997
In pDC, CpG-A trigger a TLR-9->MyD88->TRAF3->IRF-7->IFN-alpha/beta pathway.
c89 cso30:c:InputProcess connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17273997
In pDC, CpG-A trigger a TLR-9->MyD88->TRAF3->IRF-7->IFN-alpha/beta pathway.
c92 cso30:c:InputProcess connector
c93 cso30:c:InputProcess connector
c94 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c100 cso30:c:InputProcess connector
c101 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 17273997
In fact, the authors demonstrate that this pathway requires IRF-1, which is recruited and activated by MyD88.
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c97 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
c99 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
PMID: 17273997
In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.
c104 cso30:c:InputAssociation connector
c107 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
PMID: 17273997
In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.
c105 cso30:c:InputAssociation connector
c106 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 17273997
Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.
c110 cso30:c:InputProcess connector
c109 cso30:c:InputProcess connector
c108 cso30:c:InputProcess connector
c111 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17273997
Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.
c112 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c113 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17273997
Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.
c115 cso30:c:InputProcess connector
c117 cso30:c:InputAssociation connector
c116 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 17273997
IRF-1 and IRF-7 are recruited and activated through MyD88, which simultaneously triggers a parallel signaling pathway for NF-kappaB and IRF-5 activation and secretion of proinflammatory cytokines.
PMID: 17273997, 16932750
Simultaneous activation of IRF-7 by viral infection leads to IRF-7-mediated induction of IFN-alpha.
c118 cso30:c:InputProcess connector
c119 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
c122 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c123 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 17273997
The IRF-1/3/7 and the NF-kappaB/IRF-5 pathways converge at the nuclear level to enhance the transcription of type I IFN genes or other genes containing IRF and NF-kappaB binding sites in their promoters (IL-12p35, iNOS).
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17273997
Engagement of TLR-9 triggers not only the MyD88->IRF-1->IFN-beta pathway in mDC and the MyD88->IRF-7->IFN-alpha pathway in pDC, but also the MyD88->TRAF6 pathway that activates NF-kappaB in both cell types.
PMID: 17273997, 16932750
Simultaneous activation of IRF-7 by viral infection leads to IRF-7-mediated induction of IFN-alpha.
c128 cso30:c:InputAssociation connector
c127 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 17273997, 16236719
Moreover, MyD88 also recruits IRF-4, which acts a negative regulator of TLR signaling.
c129 cso30:c:InputProcess connector
c130 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17273997
Recent studies have identified pattern recognition receptors distinct from TLR, two of which, RIG-I (retinoic acid-inducible gene-I) and MDA-5 (melanoma differentiation-associated gene 5), are cytosolic RNA helicases that detect viral RNA.
c132 cso30:c:InputProcess connector
c134 cso30:c:InputProcess connector
c133 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17273997
Recent studies have identified pattern recognition receptors distinct from TLR, two of which, RIG-I (retinoic acid-inducible gene-I) and MDA-5 (melanoma differentiation-associated gene 5), are cytosolic RNA helicases that detect viral RNA.
c135 cso30:c:InputProcess connector
c136 cso30:c:InputProcess connector
c137 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c138 cso30:c:InputProcess connector
c139 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c141 cso30:c:InputProcess connector
c142 cso30:c:InputProcess connector
c143 cso30:c:InputProcess connector
c144 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 17273997
In all cells, the cytoplasmic sensors of dsRNA, MDA-5 and RIG-I, signal through the mitochondrial protein IPS-1 (interferon-beta promoter stimulator 1), which initiates a TBK->IKKepsilon->IRF-3->IFN-beta pathway.
c145 cso30:c:InputAssociation connector
c146 cso30:c:InputProcess connector
c147 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 17273997
Importantly, they found that IFN-gamma, despite its ability to induce high levels of IRF-1, does not trigger IRF-1 activation and nuclear translocation, resulting in suboptimal induction of IFN-beta, IL-12p35 and iNOS.
c149 cso30:c:InputAssociation connector
c148 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 17273997, 9490414
Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.
c153 cso30:c:InputAssociation connector
c152 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 17273997, 17273999
In mDC and macrophages CpG-B trigger a TLR-9->MyD88->IRF-1->IFN-beta pathway.
PMID: 17273997
In contrast, when IFN-gamma signaling occurs together with TLR-9 engagement, IRF-1 is not only induced but is also activated and migrates rapidly into the nucleus to mediate efficient induction of IFN-beta, iNOS and IL-12p35.
c150 cso30:c:InputAssociation connector
c151 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 17273997, 9490414
Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.
c155 cso30:c:InputAssociation connector
p60_propro_p60
PMID: 17273997, 9490414
Since IRF-1 has been shown to control NK- and T-cell development through induction of IL-15 [7], it is plausible that TLR-9 signaling also potentiates IL-15 secretion and IL-15-mediated NK- and T-cell responses to pathogenic infections.
c154 cso30:c:InputAssociation connector
c21 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17273997
In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.
c156 cso30:c:InputProcess connector
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 17273997
In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.
c159 cso30:c:InputProcess connector
c161 cso30:c:InputAssociation connector
c160 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 17273997
In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.
c162 cso30:c:InputProcess connector
c164 cso30:c:InputAssociation connector
c163 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 17273997
In virus-infected fibroblasts, IFN-beta has been shown to induce an autocrine-paracrine loop that engages the type I IFN receptors and the JAK/STAT pathway leading to induction of IRF-7.
c166 cso30:c:InputAssociation connector
c165 cso30:c:OutputProcess connector
TLRs_enti_MO000019395
TLRs
TLR3_enti_MO000019398
TLR3
TLR4_enti_MO000019394
TLR4
TLR9_enti_MO000042012
TLR9
MyD88_enti_MO000016573
MyD88
IRAK-1_enti_MO000000213
IRAK-1
IRAK-4_enti_MO000039077
IRAK-4
TRAF6_enti_MO000000212
TRAF6
TLR ligand_enti_e5
TLR ligand
TLR ligand: TLR_enti_e6
TLR ligand: TLR
IKK-i_enti_MO000016608
IKK-i
TRAF3_enti_MO000016963
TRAF3
IRF-1_enti_MO000007685
IRF-1
IRF-4_enti_MO000007697
IRF-4
IRF-3_enti_MO000007694
IRF-3
IRF-5_enti_MO000007700
IRF-5
IRF-7_enti_MO000007702
IRF-7
IRF-3{p}_enti_MO000041456
IRF-3{p}
TRIF_enti_MO000041125
TRIF
TLR ligand: TLR: MyD88_enti_e11
TLR ligand: TLR: MyD88
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4_enti_e15
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4
MDA-5_enti_MO000103999
MDA-5
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5: TRAF6_enti_e16
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5: TRAF6
TBK1_enti_MO000019331
TBK1
NF-kappaB_enti_MO000000058
NF-kappaB
IFN-beta_enti_G010228
IFN-beta
IFNbeta_enti_MO000016660
IFNbeta
dsRNA_enti_MO000022224
dsRNA
iNOS_enti_G010514
iNOS
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5_enti_e17
TLR ligand: TLR: MyD88: IRAK-1: IRAK-4: IRF-5
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
NF-kappaB {activated}_enti_e18
NF-kappaB {activated}
NF-kappaB {nucleus}_enti_e19
NF-kappaB {nucleus}
NF-kappaB: NF-kappaB target genes_enti_e20
NF-kappaB: NF-kappaB target genes
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
IL-12 p40_enti_G010657
IL-12 p40
IL-12_enti_MO000017265
IL-12
RIG-1_enti_e21
RIG-1
dsRNA: TLR3_enti_e22
dsRNA: TLR3
TLR4 ligand_enti_e23
TLR4 ligand
TLR4 ligand: TLR4_enti_e24
TLR4 ligand: TLR4
dsRNA: TLR3: TRIF_enti_e25
dsRNA: TLR3: TRIF
TLR4 ligand: TLR4: TRIF_enti_e26
TLR4 ligand: TLR4: TRIF
dsRNA: TLR3: TRIF: TRAF3_enti_e27
dsRNA: TLR3: TRIF: TRAF3
TLR4 ligand: TLR4: TRIF: TRAF3_enti_e28
TLR4 ligand: TLR4: TRIF: TRAF3
TLR4 ligand: TLR4: TRIF: TRAF3: TBK1: IKKepsilon_enti_e29
TLR4 ligand: TLR4: TRIF: TRAF3: TBK1: IKKepsilon
dsRNA: TLR3: TRIF: TRAF3: TBK1: IKKepsilon_enti_e30
dsRNA: TLR3: TRIF: TRAF3: TBK1: IKKepsilon
IRF-3{p}_enti_e31
IRF-3{p}
IRF-3: IRF-3 target genes_enti_e32
IRF-3: IRF-3 target genes
IP-10_enti_e33
IP-10
CpG-A oligonucleotides_enti_e34
CpG-A oligonucleotides
CpG-A oligonucleotides_enti_e35
CpG-A oligonucleotides
CpG-A oligonucleotides: TLR9_enti_e36
CpG-A oligonucleotides: TLR9
CpG-B oligonucleotides: TLR9_enti_e37
CpG-B oligonucleotides: TLR9
CpG-A oligonucleotides: TLR9: MyD88_enti_e38
CpG-A oligonucleotides: TLR9: MyD88
CpG-B oligonucleotides: TLR9: MyD88_enti_e39
CpG-B oligonucleotides: TLR9: MyD88
CpG-B oligonucleotides: TLR9: MyD88: IRF-1_enti_e40
CpG-B oligonucleotides: TLR9: MyD88: IRF-1
CpG-A oligonucleotides: TLR9: MyD88: TRAF3_enti_e41
CpG-A oligonucleotides: TLR9: MyD88: TRAF3
CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7_enti_e42
CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7
CpG-B oligonucleotides: TLR9: MyD88: IRF-1 {activated}_enti_e43
CpG-B oligonucleotides: TLR9: MyD88: IRF-1 {activated}
IRF-1 {activated}_enti_e44
IRF-1 {activated}
IRF-1 {nucleus}_enti_e45
IRF-1 {nucleus}
IRF-1: IRF-1 target genes_enti_e46
IRF-1: IRF-1 target genes
IL-12 p35_enti_e47
IL-12 p35
CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4_enti_e48
CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4
CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6_enti_e49
CpG-A oligonucleotides: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6
CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7 {activated}_enti_e63
CpG-A oligonucleotides: TLR9: MyD88: TRAF3: IRF-7 {activated}
IRF-7 {activated}_enti_e64
IRF-7 {activated}
IRF-7 {nucleus}_enti_e65
IRF-7 {nucleus}
IRF-7: IRF target genes_enti_e66
IRF-7: IRF target genes
IFN-alpha_enti_e67
IFN-alpha
MyD88: IRF-4_enti_e68
MyD88: IRF-4
dsRNA: MDA-5_enti_e69
dsRNA: MDA-5
dsRNA: RIG-1_enti_e70
dsRNA: RIG-1
IRF-7_enti_G010713
IRF-7
IPS-1_enti_e71
IPS-1
dsRNA: RIG-1: IPS-1_enti_e72
dsRNA: RIG-1: IPS-1
dsRNA: RIG-1: IPS-1: TBK1: IKKepsilon_enti_e73
dsRNA: RIG-1: IPS-1: TBK1: IKKepsilon
IFNgamma_enti_MO000016665
IFNgamma
IRF-1_enti_G010384
IRF-1
IL15_enti_G012390
IL15
IL-15_enti_MO000017063
IL-15
Jak1_enti_MO000000145
Jak1
Type I IFN receptor_enti_e74
Type I IFN receptor
IFNbeta: Type I IFN receptor_enti_e75
IFNbeta: Type I IFN receptor
STATs_enti_MO000016656
STATs
Jak1 {activated}_enti_e76
Jak1 {activated}
STATs {activated}_enti_e77
STATs {activated}