_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e4
_enti_e3
_enti_e2
_enti_e55
_enti_e109
_enti_e53
_enti_e59
_enti_e108
_enti_e107
_enti_e51
_enti_e56
_enti_e52
_enti_e54
_enti_e50
_enti_e61
_enti_e57
_enti_e58
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g4
p1_propro_p1
PMID: 17275323, 16497588
TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:InputProcess connector
c4 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17275323, 16497588
TLR4, together with its extracellular components such as MD-2 and CD14, recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, which causes septic shock.
PMID: 17275323, 9686597
the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.
c5 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c274 cso30:c:InputInhibitor connector
c7 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17275323, 16497588
TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
c8 cso30:c:InputProcess connector
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17275323, 16497588
TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
c11 cso30:c:InputProcess connector
c12 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17275323, 16497588
TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
c14 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17275323, 16497588
TLR2 forms heterodimers with TLR1, TLR6 and non-TLRs such as CD36 to discriminate a wide variety of PAMPs, including peptidoglycan, lipopeptides and lipoproteins of Gram-positive bacteria, mycoplasma lipopeptides and fungal zymosan.
c17 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17275323, 16497588
In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17275323, 16497588
In particular, TLR1/2 and TLR2/6 can discriminate triacyl- and diacyl-lipopeptide, respectively.
c23 cso30:c:InputProcess connector
c24 cso30:c:InputProcess connector
c25 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17275323, 16497588
In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.
c26 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17275323, 16497588
In addition, human TLR10 is thought to heterodimerize with TLR2 and TLR1, although a ligand for these heterodimers remains unknown.
c29 cso30:c:InputProcess connector
c30 cso30:c:InputProcess connector
c31 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17275323, 16497588, 16829963
TLR5 is expressed abundantly in intestinal CD11c-positive lamina propria cells where it senses bacterial flagellin.
c32 cso30:c:InputProcess connector
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17275323
Mouse TLR11 recognizes as yet unknown components of uropathogenic bacteria, and a profilin-like molecule of the protozoan parasite Toxoplasma gondii.
c35 cso30:c:InputProcess connector
c36 cso30:c:InputProcess connector
c37 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17275323
TLR3 was shown to recognize double stranded RNA (dsRNA), which is produced by many viruses during replication.
c38 cso30:c:InputProcess connector
c39 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17275323, 16497588
TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.
c41 cso30:c:InputProcess connector
c42 cso30:c:InputProcess connector
c43 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17275323, 16497588
TLR7 recognizes synthetic imidazoquinoline-like molecules, guanosine analogs such as loxoribine, single stranded RNA (ssRNA) derived from various viruses and small interfering RNA.
c44 cso30:c:InputProcess connector
c45 cso30:c:InputProcess connector
c46 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17275323
Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.
c47 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17275323
Human TLR8, which has the highest homology to TLR7, participates in the recognition of imidazoquinolines and ssRNA.
c50 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17275323, 16497588
TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.
c53 cso30:c:InputProcess connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17275323, 16497588
TLR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from the malaria parasite.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17275323
Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17275323
Following stimulation, all TLRs except for TLR3 recruit MyD88, IRAKs and TRAF6 to activate the Ubc13/TAK1 pathway.
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17275323
The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
c66 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17275323
The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
c69 cso30:c:InputProcess connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17275323
The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
c72 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17275323
The association of TLRs and MyD88 stimulates the recruitment of members of the IRAK family, including IRAK1, IRAK2, IRAK4 and IRAK-M.
c75 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17275323
Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
PMID: 17275323
TRAF4 may serve to antagonize TRAF6 function by preventing recruitment of TRAF6 to the adapter complex.
c67 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c338 cso30:c:InputInhibitor connector
c84 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17275323
Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17275323
Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
c83 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 17275323
Once phosphorylated, IRAKs dissociate from MyD88 and interact with TRAF6, a member of the TRAF family.
c85 cso30:c:InputProcess connector
c86 cso30:c:OutputProcess connector
c87 cso30:c:OutputProcess connector
p30_propro_p30
PMID; 17275323, 16056267
TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK.
c89 cso30:c:InputProcess connector
c90 cso30:c:InputProcess connector
c91 cso30:c:InputProcess connector
c92 cso30:c:OutputProcess connector
p32_propro_p32
PMID; 17275323, 16056267
TRAF6, an E3 ligase, forms a complex with Ubc13 and Uev1A to promote the synthesis of lysine 63-linked polyubiquitin chains, which in turn activate TAK1, a MAPKKK.
PMID: 17275323, 16862162
Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation.
PMID: 17275323, 15334086
A20, an inducible de-ubiqutination enzyme, removes ubiquitin moieties from TRAF6 to terminate TLR signaling.
c99 cso30:c:InputProcess connector
c339 cso30:c:InputInhibitor connector
c100 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17275323
TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.
c93 cso30:c:InputProcess connector
c97 cso30:c:InputProcess connector
c94 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 17275323
TAK1, in combination with TAB1, TAB2 and TAB3, activates two downstream pathways involving the IKK complex and the MAPK family.
c101 cso30:c:InputProcess connector
c103 cso30:c:InputAssociation connector
c102 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17275323
The IKK complex, composed of the catalytic subunits IKKalpha and IKKbeta and a regulatory subunit IKKgamma/NEMO, catalyzes the phosphorylation of IkappaB proteins.
c104 cso30:c:InputAssociation connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17275323
Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.
c107 cso30:c:InputProcess connector
c108 cso30:c:OutputProcess connector
c109 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 17275323
Phosphorylated IkappaB proteins are degraded by a proteasome-dependent pathway, allowing NF-kappaB to translocate to the nucleus.
c189 cso30:c:InputProcess connector
c111 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 17275323
TAK1 also activates the MAPK pathway, which mediates AP-1 activation.
c112 cso30:c:InputProcess connector
c119 cso30:c:InputAssociation connector
c113 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17275323
TAK1 also activates the MAPK pathway, which mediates AP-1 activation.
c115 cso30:c:InputProcess connector
c117 cso30:c:InputAssociation connector
c116 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17275323, 16862162
Although in vitro analyses have implicated Ubc13 in the activation of NF-kappaB and MAPK, via ubiquitination of TAK1, studies on mice with a conditionally deleted Ubc13 gene in various tissues have shown that it has a dispensable role in NF-kappaB activation.
c114 cso30:c:InputProcess connector
c118 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17275323, 16862162
Notably, in Ubc13-deficient cells, there is a reduction in the stimulus-dependent ubiquitination of IKKgamma/NEMO, suggesting a link between Ubc13-dependent IKKgamma/NEMO ubiquitination and MAPK activation.
c120 cso30:c:InputProcess connector
c122 cso30:c:InputAssociation connector
c121 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17275323, 11163183
LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
PMID: 17275323, 16633345
It has been reported that ABIN2 (A20-binding inhibitor of NF-kappaB 2) increases the stability of Tpl2 to facilitate ERK activation.
c123 cso30:c:InputProcess connector
c125 cso30:c:InputAssociation connector
c137 cso30:c:InputAssociation connector
c138 cso30:c:InputAssociation connector
c124 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 17275323, 11163183
LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
c126 cso30:c:InputAssociation connector
c128 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17275323, 11163183
LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
c127 cso30:c:InputAssociation connector
c130 cso30:c:InputAssociation connector
c129 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17275323, 11163183
LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
c131 cso30:c:InputProcess connector
c133 cso30:c:InputAssociation connector
c132 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 17275323, 11163183
LPS-stimulated ERKactivation and TNFalpha production is severely impaired in Tpl2-deficient macrophages, whereas activation of JNK and p38 is normal.
c134 cso30:c:InputAssociation connector
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 17275323, 14661019
Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.
c139 cso30:c:InputAssociation connector
c140 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 17275323, 14661019
Macrophages deficient for MEKK3 show defective JNK and p38 activation and IL-6 production after LPS treatment.
c142 cso30:c:InputAssociation connector
c143 cso30:c:InputAssociation connector
c141 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17275323
LPS-induced ROS production is implicated in facilitating the TRAF6-ASK1-p38 signaling axis.
c144 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p49_propro_p49
c145 cso30:c:InputAssociation connector
c148 cso30:c:InputAssociation connector
c147 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17275323
TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.
c151 cso30:c:InputProcess connector
c152 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17275323
TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.
c149 cso30:c:InputProcess connector
c150 cso30:c:InputProcess connector
c153 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17275323
TIRAP is recruited to TLR4, TLR1/2 and TLR2/6, activating the MyD88-dependent pathway.
PMID: 17275323
These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling.
PMID: 17275323
ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.
c155 cso30:c:InputProcess connector
c156 cso30:c:InputProcess connector
c259 cso30:c:InputAssociation connector
c276 cso30:c:InputInhibitor connector
c157 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
c158 cso30:c:InputProcess connector
c159 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
c161 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c163 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
c164 cso30:c:InputProcess connector
c165 cso30:c:InputProcess connector
c166 cso30:c:InputProcess connector
c167 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
c169 cso30:c:InputProcess connector
c170 cso30:c:InputProcess connector
c168 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
c171 cso30:c:InputProcess connector
c174 cso30:c:InputAssociation connector
c172 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 17275323
TRIF is recruited to TLR3 and TLR4, and interacts with TBK1 and IKKi, which mediate phosphorylation of IRF3.
PMID: 17275323
The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway.
c175 cso30:c:InputProcess connector
c173 cso30:c:InputAssociation connector
c318 cso30:c:InputInhibitor connector
c176 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 17275323
Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
c177 cso30:c:InputProcess connector
c178 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 17275323
Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
c179 cso30:c:InputProcess connector
c180 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17275323
Phosphorylated IRF3 dimerizes and is translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
c181 cso30:c:InputAssociation connector
c182 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 17275323
TRAF3 forms a complex with TBK1 and IKKi.
c183 cso30:c:InputProcess connector
c184 cso30:c:InputProcess connector
c185 cso30:c:InputProcess connector
c186 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 17275323, 16115877
RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.
c188 cso30:c:InputProcess connector
c187 cso30:c:InputProcess connector
c208 cso30:c:InputProcess connector
c192 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 17275323
TRIF interacts with TRAF6 and RIP1, which mediate NF-kappaB activation.
PMID: 17275323
The cleaved fragment of TRAF1 can inhibit TRIF-dependent activation of NF-kappaB and IRF3, suggesting that TRIF-induced cleavage of TRAF1 is responsible for shutdown of the TRIFdependent pathway.
PMID: 17275323, 16052631
TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.
c110 cso30:c:InputProcess connector
c193 cso30:c:InputAssociation connector
c317 cso30:c:InputInhibitor connector
c323 cso30:c:InputInhibitor connector
c190 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 17275323
In pDC, a signaling complex consisting of MyD88-TRAF6-IRAK4-IRAK1-IRF7 is formed.
c194 cso30:c:InputProcess connector
c195 cso30:c:InputProcess connector
c196 cso30:c:InputProcess connector
c197 cso30:c:InputProcess connector
c198 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 17275323
In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
c199 cso30:c:InputProcess connector
c200 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 17275323
OPN-i, TRAF3 and IKKalpha are also involved in this complex.
c201 cso30:c:InputProcess connector
c202 cso30:c:InputProcess connector
c203 cso30:c:InputProcess connector
c226 cso30:c:InputProcess connector
c204 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 17275223
Phosphorylated IRF3 forms a dimer, which translocates from cytoplasm to the nucleus to induce expression of target genes including IFNbeta.
c205 cso30:c:InputAssociation connector
c206 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 17275323, 16115877
RIP1 is reportedly polyubiquitinated and forms a complex with TRAF6 and TAK1.
c191 cso30:c:InputProcess connector
c207 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 17275323
IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.
c209 cso30:c:InputAssociation connector
c210 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 17275323
IRF7 potently activates the promoter of IFNbeta and various IFNalpha genes.
c212 cso30:c:InputAssociation connector
c211 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 17275323, 12356687, 12626561
Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.
c214 cso30:c:InputAssociation connector
c213 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 17275323, 12356687, 12626561
Notably, TLR7- and TLR9-mediated type I IFN induction is elicited by the MyD88-dependent pathway, but not by the TRIF-dependent pathway.
c215 cso30:c:InputAssociation connector
c216 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 17275323
TRAF3 is also required for TBK1/IKKi-dependent IRF7 and IRF3 activation in TLR3 and RIG-I/Mda5-signaling.
c217 cso30:c:InputProcess connector
c219 cso30:c:InputAssociation connector
c218 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 17275323
IRF7 also participates in type I IFN induction activated by the cytosolic RNA helicases RIG-I and Mda5, which recognize viral dsRNA, in conventional DC, macrophages and fibroblast cells.
c221 cso30:c:InputAssociation connector
c220 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 17275323
TRAF3 is also necessary for the induction of anti-inflammatory cytokine IL- 10, but not pro-inflammatory cytokines, in response to ligands specific for TLR3, 4, 7 and 9.
c222 cso30:c:InputAssociation connector
c223 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 17275323, 16604075
pDC isolated from either T-bet- or OPN deficient mice have defects in the induction of type I IFN in response to TLR9-ligand, but they can produce NF-kappaB-driven IL-6 as usual.
c225 cso30:c:InputAssociation connector
c224 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 17275323
Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.
c229 cso30:c:InputAssociation connector
c227 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 17275323
Conventional DC derived from IRF1-deficient mice display impaired induction of IFNbeta, inducible nitric-oxide synthase and IL-12 p35, in response to a TLR9 ligand.
c230 cso30:c:InputAssociation connector
c228 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 17275323
IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
c231 cso30:c:InputProcess connector
c232 cso30:c:InputProcess connector
c234 cso30:c:InputAssociation connector
c233 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 17275323
IFNgamma stimulation induces IRF1 expression.
c235 cso30:c:InputAssociation connector
c236 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 17275323
IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
c238 cso30:c:InputAssociation connector
c237 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 17275323
IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.
PMID: 17275323
As expression of the IRF4 gene is upregulated after exposure with TLR ligands, the induced IRF4 might associate with MyD88 to prevent recruitment of IRF5, thereby attenuating IRF5-dependent inflammatory responses.
c239 cso30:c:InputProcess connector
c241 cso30:c:InputProcess connector
c242 cso30:c:InputProcess connector
c354 cso30:c:InputInhibitor connector
c240 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 17275323
IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.
c243 cso30:c:InputProcess connector
c244 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 17275323, 16757566
TRAM is phosphorylated at serine 16 by PKCepsilon in response to LPS.
c245 cso30:c:InputAssociation connector
c246 cso30:c:InputProcess connector
c248 cso30:c:InputAssociation connector
c247 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 17275323
Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
c361 cso30:c:InputAssociation connector
c250 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 17275323
Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
c252 cso30:c:InputProcess connector
c256 cso30:c:InputAssociation connector
c253 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 17275323
These findings suggest that TLR4 recruits TIRAP to the plasma membrane as a result of CD11b-mediated production of PIP2, which subsequently recruits MyD88 after which the signaling complex is assembled to initiate the MyD88-dependent signaling.
PMID: 17275323
ST2L sequesters MyD88 and TIRAP to inhibit the recruitment of these adapters to TLR4.
c260 cso30:c:InputProcess connector
c261 cso30:c:InputProcess connector
c275 cso30:c:InputInhibitor connector
c262 cso30:c:OutputProcess connector
p91_propro_p91
c263 cso30:c:InputProcess connector
c265 cso30:c:InputAssociation connector
c264 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 17275323
The LRR of RP105 associate with MD-1 to form a complex on the cell surface.
c268 cso30:c:InputProcess connector
c269 cso30:c:InputProcess connector
c270 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 17275323, 9686597
the RP105-MD-1 complex interacts with a TLR4-MD-2 complex to prevent LPS binding to TLR4-MD-2.
c271 cso30:c:InputProcess connector
c273 cso30:c:InputProcess connector
c272 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 17275323
SIGIRR interacts with IRAKs and TRAF6 to block TLR signaling.
c277 cso30:c:InputProcess connector
c278 cso30:c:InputProcess connector
c279 cso30:c:InputProcess connector
c280 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 17275323
Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.
c281 cso30:c:InputProcess connector
c282 cso30:c:InputProcess connector
c286 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 17275323
Triad3A is an E3 ligase that binds the TIR domain of TLR4 and 9, but not that of TLR2.
c283 cso30:c:InputProcess connector
c284 cso30:c:InputProcess connector
c285 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 17275323
Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.
c288 cso30:c:InputProcess connector
c289 cso30:c:OutputProcess connector
c292 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 17275323
Triad3 overexpression promotes degradation of TLR4 and 9 via a proteasome-dependent pathway.
c287 cso30:c:InputProcess connector
c290 cso30:c:OutputProcess connector
c291 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 17275323
MyD88s forms a heterodimer with MyD88.
c293 cso30:c:InputProcess connector
c294 cso30:c:InputProcess connector
c295 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c296 cso30:c:InputProcess connector
c297 cso30:c:InputAssociation connector
c300 cso30:c:InputAssociation connector
c298 cso30:c:OutputProcess connector
p102_propro_p102
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c302 cso30:c:InputProcess connector
c303 cso30:c:InputProcess connector
c304 cso30:c:OutputProcess connector
p103_propro_p103
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c305 cso30:c:InputProcess connector
c306 cso30:c:OutputProcess connector
c307 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c308 cso30:c:InputProcess connector
c309 cso30:c:OutputProcess connector
p105_propro_p105
PMID: 17275323, 16323247
TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.
c310 cso30:c:InputProcess connector
c311 cso30:c:InputProcess connector
c312 cso30:c:OutputProcess connector
p106_propro_p106
PMID: 17275323, 16323247
TRAF1 interacts with TRIF and overexpression of TRIF causes Caspase 8-dependent cleavage of TRAF1.
c313 cso30:c:InputProcess connector
c316 cso30:c:InputAssociation connector
c314 cso30:c:OutputProcess connector
c315 cso30:c:OutputProcess connector
p107_propro_p107
PMID: 17275323, 16052631
TRAF4 interacts with TRIF and TRAF6, and its overexpression results in inhibition of NF-kappaB activation induced by TRIF and TRAF6.
c319 cso30:c:InputProcess connector
c320 cso30:c:InputProcess connector
c321 cso30:c:InputProcess connector
c322 cso30:c:OutputProcess connector
p108_propro_p108
PMID: 17275323
In this complex, IRF7 is directly phosphorylated by IRAK1, and then translocated to the nucleus to induce expression of type I IFN and IFN-inducible genes.
c324 cso30:c:InputProcess connector
c325 cso30:c:OutputProcess connector
c326 cso30:c:OutputProcess connector
p109_propro_p109
PMID: 17275323
In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.
c327 cso30:c:InputProcess connector
c331 cso30:c:InputAssociation connector
c328 cso30:c:OutputProcess connector
p110_propro_p110
PMID: 17275323
In pDC, OPN expression is upregulated by TLR9 ligand through T-bet, a master transcription factor driving Th1 differentiation.
c329 cso30:c:InputAssociation connector
c330 cso30:c:OutputProcess connector
p111_propro_p111
PMID: 17275323
IRF1 is recruited to MyD88 when it is induced by IFNgamma stimulation, and translocates into the nucleus in response to TLR stimulation to induce a set of genes including IFNbeta in conventional DC.
c332 cso30:c:InputProcess connector
c333 cso30:c:OutputProcess connector
c334 cso30:c:OutputProcess connector
p112_propro_p112
PMID: 17275323
IRF5 binds MyD88 and TRAF6 and moves to the nucleus after phosphorylation.
c335 cso30:c:InputProcess connector
c336 cso30:c:OutputProcess connector
c337 cso30:c:OutputProcess connector
p113_propro_p113
PMID: 17275323
The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
c341 cso30:c:InputProcess connector
c343 cso30:c:InputProcess connector
c344 cso30:c:OutputProcess connector
p114_propro_p114
PMID: 17275323
The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
c340 cso30:c:InputProcess connector
c342 cso30:c:OutputProcess connector
p115_propro_p115
PMID: 17275323
The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
c360 cso30:c:InputProcess connector
c345 cso30:c:OutputProcess connector
c346 cso30:c:OutputProcess connector
p116_propro_p116
PMID: 17275323
The cytoplasmic peptidyl-prolyl-isomerase Pin1, which catalyzes the cis-trans isomerization of peptide-bonds located N-terminal to proline to modulate substrate function, binds IRF3 when it is phosphorylated at Ser339, triggering ubiquitination and subsequent degradation of IRF3 by a proteasome-dependent pathway to terminate IFN responses.
c347 cso30:c:InputProcess connector
c348 cso30:c:OutputProcess connector
p117_propro_p117
PMID: 17275323
LPS stimulation leads to the expression of ATF3, a member of the ATF/CREB family of transcription factors.
c350 cso30:c:InputAssociation connector
c349 cso30:c:OutputProcess connector
p118_propro_p118
PMID: 17275323, 16236719
IRF4 is reported to bind MyD88.
c351 cso30:c:InputProcess connector
c352 cso30:c:InputProcess connector
c353 cso30:c:OutputProcess connector
p101_propro_p119
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c356 cso30:c:InputAssociation connector
c357 cso30:c:InputAssociation connector
c299 cso30:c:InputProcess connector
c301 cso30:c:OutputProcess connector
p101_propro_p120
PMID: 17275323, 16415872
TIRAP is phosphorylated by a tyrosine kinase, Btk, in response to TLR2 and TLR4 ligands, and interacts with SOCS1, which subsequently targets TIRAP for ubiquitination and degradation.
c64 cso30:c:InputAssociation connector
c355 cso30:c:InputAssociation connector
c358 cso30:c:InputProcess connector
c359 cso30:c:OutputProcess connector
p87_propro_p121
PMID: 17275323
Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
c362 cso30:c:InputAssociation connector
c363 cso30:c:OutputProcess connector
p87_propro_p122
PMID: 17275323
Integrin signaling regulates the production of PIP2 through the activation of ARF6 GTPase and PI5K.
c255 cso30:c:InputAssociation connector
c364 cso30:c:OutputProcess connector
TLR4_enti_MO000019394
TLR4
CD14_enti_MO000018132
CD14
MD-2_enti_MO000022131
MD-2
CD14: TLR4: MD-2_enti_e5
CD14: TLR4: MD-2
LPS_enti_MO000016882
LPS
LPS: CD14: TLR4: MD-2_enti_e6
LPS: CD14: TLR4: MD-2
TLR2_enti_MO000019397
TLR2
TLR1:TLR2_enti_e11
TLR1:TLR2
TLR1_enti_MO000019396
TLR1
TLR10_enti_MO000042128
TLR10
CD36_enti_e12
CD36
TLR1:TLR2: CD36_enti_e13
TLR1:TLR2: CD36
TLR6_enti_MO000019422
TLR6
TLR6: TLR2_enti_e14
TLR6: TLR2
TLR6: TLR2: CD36_enti_e15
TLR6: TLR2: CD36
triacyl-lipopeptide: TLR1:TLR2: CD36_enti_e16
triacyl-lipopeptide: TLR1:TLR2: CD36
triacyl-lipopeptide_enti_e17
triacyl-lipopeptide
diacyl-lipopeptide_enti_e18
diacyl-lipopeptide
diacyl-lipopeptide: TLR6: TLR2: CD36_enti_e19
diacyl-lipopeptide: TLR6: TLR2: CD36
TLR1: TLR10_enti_e20
TLR1: TLR10
TLR2: TLR10_enti_e21
TLR2: TLR10
flagellin_enti_MO000022185
flagellin
TLR5_enti_MO000019399
TLR5
flagellin: TLR5_enti_e22
flagellin: TLR5
TLR11_enti_MO000042130
TLR11
profilin-like molecule_enti_e23
profilin-like molecule
profilin-like molecule: TLR11_enti_e24
profilin-like molecule: TLR11
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
dsRNA_enti_MO000022224
dsRNA
loxoribidine_enti_e25
loxoribidine
TLR7_enti_MO000042126
TLR7
loxoribidine: TLR7_enti_e26
loxoribidine: TLR7
ssRNA_enti_e27
ssRNA
ssRNA: TLR7_enti_e28
ssRNA: TLR7
imidazoquinolines_enti_e29
imidazoquinolines
TLR8_enti_MO000042007
TLR8
ssRNA: TLR8_enti_e30
ssRNA: TLR8
imidazoquinolines: TLR8_enti_e31
imidazoquinolines: TLR8
TLR9_enti_MO000042012
TLR9
CpG DNA_enti_e32
CpG DNA
CpG DNA: TLR9_enti_e33
CpG DNA: TLR9
hemozoin_enti_e34
hemozoin
hemozoin: TLR9_enti_e35
hemozoin: TLR9
MyD88_enti_MO000016573
MyD88
IRAK1_enti_e36
IRAK1
IRAK-2_enti_MO000016566
IRAK-2
IRAK-M_enti_MO000016569
IRAK-M
TRAF6_enti_MO000000212
TRAF6
TLR_enti_e37
TLR
ligand_enti_e38
ligand
ligand: TLR_enti_e39
ligand: TLR
ligand: TLR: MyD88_enti_e40
ligand: TLR: MyD88
ligand: TLR: MyD88: IRAK-4_enti_e41
ligand: TLR: MyD88: IRAK-4
ligand: TLR: MyD88: IRAK1_enti_e42
ligand: TLR: MyD88: IRAK1
ligand: TLR: MyD88: IRAK-M_enti_e43
ligand: TLR: MyD88: IRAK-M
ligand: TLR: MyD88: IRAK-2_enti_e44
ligand: TLR: MyD88: IRAK-2
IRAK: TRAF6_enti_e45
IRAK: TRAF6
IRAK_enti_MO000021842
IRAK
IRAK-4_enti_MO000039077
IRAK-4
ligand: TLR: MyD88: IRAK_enti_e46
ligand: TLR: MyD88: IRAK
ligand: TLR: MyD88: IRAK {p}_enti_e47
ligand: TLR: MyD88: IRAK {p}
IRAK { p}_enti_e49
IRAK { p}
Ubc13_enti_MO000022136
Ubc13
Uev1A_enti_e48
Uev1A
IRAK: TRAF6: Ubc13: Uev1A_enti_e63
IRAK: TRAF6: Ubc13: Uev1A
TAK1_enti_MO000016574
TAK1
TAB1_enti_MO000016588
TAB1
TAB3_enti_MO000041541
TAB3
IRAK: TRAF6 {ub}: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3_enti_e64
IRAK: TRAF6 {ub}: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3
TAB2_enti_MO000022125
TAB2
IRAK: TRAF6: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3_enti_e65
IRAK: TRAF6: Ubc13: Uev1A: TAK1: TAB1: TAB2: TAB3
IKK-alpha:IKK-beta:IKK-gamma_enti_MO000016661
IKK-alpha:IKK-beta:IKK-gamma
IKK-alpha:IKK-beta:IKK-gamma {activated}_enti_e66
IKK-alpha:IKK-beta:IKK-gamma {activated}
IkappaB_enti_MO000000215
IkappaB
IkappaB {p}_enti_e68
IkappaB {p}
degraded IkappaB_enti_e67
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB {nucleus}_enti_e69
NF-kappaB {nucleus}
MAPKs_enti_MO000000077
MAPKs
MAPKs {activated}_enti_e70
MAPKs {activated}
AP-1_enti_MO000000276
AP-1
AP-1 {activated}_enti_e71
AP-1 {activated}
IRAK: TRAF6: Ubc13: Uev1A: TAK1{ub}: TAB1: TAB2: TAB3_enti_e72
IRAK: TRAF6: Ubc13: Uev1A: TAK1{ub}: TAB1: TAB2: TAB3
IKK-gamma_enti_MO000016599
IKK-gamma
IKK-gamma(m.s.){ub}_enti_e73
IKK-gamma(m.s.){ub}
ERK_enti_MO000000011
ERK
ERK {activated}_enti_e74
ERK {activated}
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
JNK_enti_MO000000023
JNK
JNK {activated}_enti_e75
JNK {activated}
p38_enti_MO000000022
p38
p38 {activated}_enti_e76
p38 {activated}
Tpl2_enti_MO000000041
Tpl2
ABIN2_enti_e77
ABIN2
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
ROS_enti_MO000008272
ROS
ROS_enti_e78
ROS
TIRAP_enti_MO000022528
TIRAP
diacyl-lipopeptide: TLR6: TLR2: CD36: TIRAP_enti_e79
diacyl-lipopeptide: TLR6: TLR2: CD36: TIRAP
triacyl-lipopeptide: TLR1:TLR2: CD36: TIRAP_enti_e80
triacyl-lipopeptide: TLR1:TLR2: CD36: TIRAP
LPS: CD14: TLR4: MD-2: TIRAP_enti_e81
LPS: CD14: TLR4: MD-2: TIRAP
TRIF_enti_MO000041125
TRIF
dsRNA:TLR3: TRIF_enti_e82
dsRNA:TLR3: TRIF
LPS: CD14: TLR4: MD-2: TRIF_enti_e83
LPS: CD14: TLR4: MD-2: TRIF
TBK1_enti_MO000019331
TBK1
IKK-i_enti_MO000016608
IKK-i
dsRNA:TLR3: TRIF: TBK1: IKK-i_enti_e84
dsRNA:TLR3: TRIF: TBK1: IKK-i
LPS: CD14: TLR4: MD-2: TRIF: TBK1: IKK-i_enti_e85
LPS: CD14: TLR4: MD-2: TRIF: TBK1: IKK-i
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_MO000041456
IRF-3{p}
IRF-3{p}: IRF-3_enti_e86
IRF-3{p}: IRF-3
IRF-3{p}: IRF-3 {nucleus}_enti_e87
IRF-3{p}: IRF-3 {nucleus}
Type I IFN_enti_e88
Type I IFN
TRAF3_enti_MO000016963
TRAF3
TBK1: IKK-i: TRAF3_enti_e89
TBK1: IKK-i: TRAF3
NF-kappaB {activated}_enti_e90
NF-kappaB {activated}
RIP1_enti_MO000000065
RIP1
TRIF: TRAF6: RIP1_enti_e91
TRIF: TRAF6: RIP1
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7_enti_e92
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7
IRF-7_enti_MO000007702
IRF-7
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}_enti_e93
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}
OPN-i_enti_e94
OPN-i
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}: OPN-i: IKK-alpha: TRAF3_enti_e101
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: IRF-7 {p}: OPN-i: IKK-alpha: TRAF3
IKK-alpha_enti_MO000000210
IKK-alpha
IFN-beta_enti_G010228
IFN-beta
RIP1(m.s.){ub}_enti_e102
RIP1(m.s.){ub}
IRF-7 {nucleus}_enti_e103
IRF-7 {nucleus}
IFN-alpha(h)_enti_e104
IFN-alpha(h)
IRF-7 {p}_enti_e105
IRF-7 {p}
IL10_enti_G011345
IL10
IL-12 p35_enti_e95
IL-12 p35
NOS_enti_e96
NOS
IRF-1_enti_MO000007685
IRF-1
MyD88: IRF1_enti_e97
MyD88: IRF1
IFNgamma_enti_MO000016665
IFNgamma
IRF-1_enti_G010384
IRF-1
IRF-1 {nucleus}_enti_e98
IRF-1 {nucleus}
IRF-5_enti_MO000007700
IRF-5
MyD88: TRAF6: IRF-5_enti_e99
MyD88: TRAF6: IRF-5
MyD88: TRAF6: IRF-5 {p}_enti_e100
MyD88: TRAF6: IRF-5 {p}
TRAM_enti_MO000041132
TRAM
TRAM {p}_enti_e110
TRAM {p}
PKCepsilon_enti_MO000016645
PKCepsilon
PIP2_enti_MO000000331
PIP2
ARF6 GTPase_enti_e106
ARF6 GTPase
ARF6 GTPase {activated}_enti_e112
ARF6 GTPase {activated}
integrins_enti_MO000017291
integrins
CD11b_enti_e113
CD11b
LPS: CD14: TLR4: MD-2: TIRAP: MyD88_enti_e114
LPS: CD14: TLR4: MD-2: TIRAP: MyD88
PI5K {activated}_enti_e115
PI5K {activated}
PI5K_enti_e116
PI5K
RP105_enti_MO000016653
RP105
MD-1_enti_MO000022200
MD-1
RP105:MD-1_enti_e117
RP105:MD-1
RP105: MD-1: MD-2: TLR4_enti_e118
RP105: MD-1: MD-2: TLR4
MD-2: TLR4_enti_e119
MD-2: TLR4
ST2L_enti_MO000044794
ST2L
SIGIRR_enti_MO000066718
SIGIRR
SIGIRR: IRAK: TRAF6_enti_e120
SIGIRR: IRAK: TRAF6
Triad3A_enti_e121
Triad3A
TLR9: Triad3A_enti_e122
TLR9: Triad3A
TLR4: Triad3A_enti_e123
TLR4: Triad3A
TLR9 {degraded}_enti_e124
TLR4 {degraded}_enti_e125
MyD88s_enti_e126
MyD88s
MyD88: MyD88s_enti_e127
MyD88: MyD88s
Btk_enti_MO000001935
Btk
TIRAP {p}_enti_e128
TIRAP {p}
SOCS-1_enti_MO000017004
SOCS-1
TIRAP{p}: SOCS-1_enti_e129
TIRAP{p}: SOCS-1
TIRAP {ub}_enti_e130
TIRAP {ub}
TIRAp {degraded}_enti_e131
TRAF1_enti_MO000016962
TRAF1
TRIF: TRAF1_enti_e132
TRIF: TRAF1
TRAF1 {degraded}_enti_e133
Caspase-8_enti_MO000016900
Caspase-8
TRAF4_enti_MO000016964
TRAF4
TRAF4: TRAF6: TRIF_enti_e134
TRAF4: TRAF6: TRIF
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: OPN-i: IKK-alpha: TRAF3_enti_e135
ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6: OPN-i: IKK-alpha: TRAF3
T-bet_enti_MO000090987
T-bet
T-bet {activated}_enti_e136
T-bet {activated}
opn_enti_G010660
opn
IRF-5 {nucleus}_enti_e137
IRF-5 {nucleus}
MyD88: TRAF6_enti_e138
MyD88: TRAF6
A20_enti_MO000016591
A20
Pin1_enti_MO000017197
Pin1
Pin1: IRF-3 {p339}_enti_e139
Pin1: IRF-3 {p339}
IRF-3 {p339}_enti_e140
IRF-3 {p339}
IRF-3{ub}_enti_e141
IRF-3{ub}
IRF-3 {degraded}_enti_e142
ATF3_enti_G010779
ATF3
IRF-4_enti_MO000007697
IRF-4
MyD88: IRF-4_enti_e143
MyD88: IRF-4