1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17307033.csml convertedTime:2009.07.01.11:01

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title RIG-I: tri-ing to discriminate between self and non-self RNA.
Authors Bowie AG, Fitzgerald KA.
Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2,Ireland.
Abstract The ability to distinguish foreign nucleic acids from abundant self nucleicacids is essential to protect the host from invading pathogens. Several innateimmune surveillance systems have evolved to detect nucleic acids and triggercellular responses to eliminate foreign invaders. For RNA recognition, theseinclude double stranded (ds)RNA-dependent protein kinase, Toll-like receptor(TLR)3, TLR7, TLR8, retinoic acid-inducible gene (RIG)-I and melanomadifferentiation-associated gene 5. In the case of the nucleic-acid-sensing TLRs,endosomal localization is thought to be crucial for providing self versusnon-self discrimination. For RNA-sensing in the cytoplasm, RIG-I was recentlyshown to detect and directly bind to the 5'-end of certain viral RNA genomes,specifically, to a 5'-triphosphate group. Such 5'-triphosphates are generallyremoved from, or masked on, host RNA species, thereby remaining silent to innateimmunity and providing a structural basis for the distinction between self andnon-self RNA. The mechanisms by which MDA5 senses RNA are unclear at present butseem to involve the sensing of dsRNA structures.
PMID 17307033
Model Abstract

Entity

MO000000214:IL-1 MO000007330:proIL-18 MO000008179:PKR MO000016625:IL-18 MO000016828:Caspase-1 MO000019398:TLR3 MO000022224:dsRNA MO000022225:dsRNA:PKR MO000022570:eIF-2alpha MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042126:TLR7 MO000066987:DDX58 MO000103999:IFIH1 e1: e10: e11:ssRNA e12:ssRNA:TLR7 e13:ssRNA:TLR8 e14:DDX58:ssRNA e15:DDX58{active}:ssRNA e16:V proteins e17:MDA5:V proteins e18:IAV NS1 e19:DDX58:IAV NS1 e2: e20:IFN e21:IFN e22:dsRNA:TLR3 e23:IFN-alpha e24:IFN alpha e25:Pro IL-1 e26:Nalp3 e27:Caspase-1{active} e28:Poly I:C e3: e4: e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7: e8:eIF-2alpha{p} e9:TLR3

Process

p1 p10 p11 p12 p13 p14 p15 p16 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
193.0, 1089.0
22.0, 22.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
178.0, 854.0
20.0, 20.0

proIL-18

--

MO000007330

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m841

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000007330

--

Go back
961.0, 245.0
21.0, 21.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
158.0, 958.0
20.0, 20.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
377.0, 905.0
22.0, 22.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
762.0, 402.0
19.0, 19.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1028.0, 316.0
24.5, 24.5

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p8 p3 p14

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
959.0, 295.0
26.0, 26.0

dsRNA:PKR

--

MO000022225

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6524

10

false

infinite

0

unit false false false
TRANSPATHMO000022225

--

Go back
745.0, 245.0
22.0, 22.0

eIF-2alpha

--

MO000022570

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m6843

10

false

infinite

0

unit false false false
InterProIPR003029
TRANSPATHMO000022570

--

Go back
822.0, 442.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
847.0, 523.0
18.0, 18.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
786.0, 482.0
20.0, 20.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
462.0, 458.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p9

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
370.0, 658.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
230.69102120526588, 9.438482645500528
771.4745774779069, 1592.6553516979416

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
234.3453097307387, 39.95936587271336
763.8196788892242, 1527.677594910579

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1075.5, 446.0
25.48679245283019, 27.803773584905663

ssRNA

--

e11

cso30:c:RnaOther

cso30:i:CC_Cytosol

--

--

p4 p5 p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
757.5, 540.0
16.5297083972813, 31.992983994738005

ssRNA:TLR7

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
843.5, 576.0
16.951107213330413, 32.808594606445965

ssRNA:TLR8

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
557.0, 520.0
21.331491712707173, 23.701657458563535

DDX58:ssRNA

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
629.0, 696.0
21.331491712707173, 23.701657458563535

DDX58{active}:ssRNA

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
449.0, 626.5
30.984101428858924, 19.10686254779634

V proteins

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
442.5, 748.0
18.943509415097477, 23.19613397767039

MDA5:V proteins

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
388.0, 394.5
24.159999999999997, 18.119999999999997

IAV NS1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
383.5, 461.0
24.397933677720385, 29.8750208298617

DDX58:IAV NS1

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
230.69102120526588, 9.438482645500528
771.4745774779069, 1592.6553516979416

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
692.0, 851.0
47.33564013840831, 25.24567474048443

IFN

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p10

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1023.5, 826.0
16.701750855302876, 27.08392030589656

IFN

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
966.0, 590.0
20.0, 20.0

dsRNA:TLR3

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1029.5, 905.0
13.767961360434697, 22.326423827731936

IFN-alpha

--

e23

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p11

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
696.0, 915.0
47.33564013840831, 25.24567474048443

IFN alpha

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
97.0, 1005.0
22.0, 22.0

Pro IL-1

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
489.0, 1135.0
14.410664172123475, 33.25537885874648

Nalp3

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14 p15

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
405.0, 1021.0
22.0, 22.0

Caspase-1{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
118.0, 719.0
37.54415475189234, 21.275021026072327

Poly I:C

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
246.12051275482412, 31.37588418403985
740.6155943787909, 1548.7805486208629

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
274.66507212150594, 69.76633687648273
683.5264756454258, 1471.999643235976

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
720.3483587127605, 386.54768361367644
174.4322530483757, 291.21316822483055

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
566.7687311269026, 758.5454579277073
299.3216957755016, 385.9459093310221

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
599.0977038549827, 767.6918149017545
175.02236959684825, 374.0584583249335

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
570.6705036975331, 763.6966866970124
291.51815063424107, 375.64345179241195

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
571.2278997790515, 764.4891834307514
290.40335847120366, 374.0584583249335

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
566.7687311269026, 758.5454579277073
299.3216957755016, 385.9459093310221

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
566.7687311269026, 758.5454579277073
299.3216957755016, 385.9459093310221

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
571.2278997790515, 764.4891834307514
290.40335847120366, 374.0584583249335

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
785.2679950822032, 917.04480467556
18.699974927776488, 24.06852299312129

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
736.2171399085639, 1027.9943473990566
52.952627744269336, 68.15471910157684

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
566.7687311269026, 758.5454579277073
299.3216957755016, 385.9459093310221

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
720.3483587127605, 386.54768361367644
174.4322530483757, 291.21316822483055

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
637.3171706539299, 930.0566309371109
9.479078298177217, 6.489022326156442

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
637.0006373982494, 910.7048308056465
32.444658707263365, 83.03272381988937

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
650.6115673925166, 964.7098544283385
5.0645320908898785, 7.200669816358965

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
720.3483587127605, 386.54768361367644
174.4322530483757, 291.21316822483055

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
753.0, 300.0
29.8780487804878, 23.902439024390247

eIF-2alpha{p}

--

e8

cso30:c:Protein

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
962.0, 402.0
19.0, 19.0

TLR3

--

e9

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m9

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1057.0, 245.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m1055*0.1

nodelay

--

true

0

false

PMID: 17307033,11752661 The first dsRNA-binding protein to be described was PKR (Table 1), a key mediator of the antiviral action of type I interferon (IFN) PMID: 17307033 A pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA.

Go back
881.0, 829.0
21.0, 21.0

p10

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17307033,17038589 The Pichlmair study also demonstrated that the IAV NS1 protein, which was thought to block IFN induction by sequestering dsRNA, instead blocks by forming a complex with RIG-I to abrogate RIG-I signaling

Go back
881.0, 909.0
21.0, 21.0

p11

p11

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c8 : 1
stoichiometry:c32 : 1

m24*m15*0.1

nodelay

--

true

0

false

PMID: 17303033 Therefore, during infection, RIG-I probably mediates local IFNa production, which is crucial for the initial antiviral response, whereas TLR7 controls systemic IFNa levels, as pDCs make a substantial contribution to the total IFNa produced during an infection.

Go back
197.0, 1009.0
21.0, 21.0

p13

p12

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c49 : 1
stoichiometry:c39 : 1

m25*m27*0.1

nodelay

--

true

0

false

PMID: 17303033,17008311 An additional antiviral effector mechanism involves the production of the inflammatory cytokines interleukin (IL)-1 and IL-18, which are generated by proteolytic processing of their pro-forms through the action of caspase-1

Go back
189.0, 913.0
21.0, 21.0

p13

p13

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c48 : 1
stoichiometry:c36 : 1

m841*m27*0.1

nodelay

--

true

0

false

PMID: 17303033,17008311 An additional antiviral effector mechanism involves the production of the inflammatory cytokines interleukin (IL)-1 and IL-18, which are generated by proteolytic processing of their pro-forms through the action of caspase-1

Go back
518.0, 1042.0
20.0, 20.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1

m26*m1765*m119368*0.1

nodelay

--

true

0

false

PMID: 17307033,17008311 Poly(I:C), viral dsRNA and Sendai virus (SeV) all activated caspase-1 through the nucleotide oligomerization domainlike receptor protein Nalp3 (also known as cryopyrin)

Go back
458.0, 862.0
20.0, 20.0

p14

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m26*m28*m1765*0.1

nodelay

--

true

0

false

PMID: 17307033,17008311 Poly(I:C), viral dsRNA and Sendai virus (SeV) all activated caspase-1 through the nucleotide oligomerization domainlike receptor protein Nalp3 (also known as cryopyrin)

Go back
558.0, 626.0
19.0, 19.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c37 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17307033 Moreover, they found that ssRNA such as that from the influenza virus genome, which is uncapped and has a 50-triphosphate moiety, associated with and activated RIG-I.

Go back
842.0, 246.0
19.0, 19.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c50 : 1
stoichiometry:c9 : 1

m6843*m6524*0.1

nodelay

--

true

0

false

PMID: 17307033 A pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA. PKR functions to phosphorylate the a subunit of the translation initiation factor eIF2, thereby inhibiting protein synthesisA pair of dsRNA-binding domains in the N-terminal portion of PKR binds to dsRNA. PKR functions to phosphorylate the a subunit of the translation initiation factor eIF2, thereby inhibiting protein synthesis

Go back
1049.0, 389.0
21.0, 21.0

p8

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m119368*m9*0.1

nodelay

--

true

0

false

PMID: 17307033,15961631,16043704 The TLR3 ectodomain senses dsRNA both extracellularly and in endosomes, and its structure has been solved recently

Go back
894.0, 426.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c17 : 1

m11*m19940*0.1

nodelay

--

true

0

false

PMID: 17307033 Single-stranded RNA of ssRNA viruses is detected through TLR7 and TLR8, which are located in the endosomal compartment

Go back
906.0, 522.0
19.0, 19.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1

m11*m19823*0.1

nodelay

--

true

0

false

PMID: 17307033 Single-stranded RNA of ssRNA viruses is detected through TLR7 and TLR8, which are located in the endosomal compartment

Go back
557.0, 449.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c34 : 1
stoichiometry:c20 : 1

m41844*m11*0.1

nodelay

--

true

0

false

PMID: 17307033,17038590 Artificial capping or base modification of this 50-triphosphate (as would occur in host RNA) abolished this response, which they showed was mediated by direct binding to RIG-I PMID: 17307033 Moreover, they found that ssRNA such as that from the influenza virus genome, which is uncapped and has a 50-triphosphate moiety, associated with and activated RIG-I.

Go back
461.0, 693.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m76904*m16*0.1

nodelay

--

true

0

false

PMID: 17307033,16672351,16625202,16714379 However, a current paradox is that, although negative-stranded paramyxoviruses do not produce detectable amounts of dsRNA, and are detected by RIG-I and not MDA5 their V proteins bind to Mda5 (and not RIG-I) and inhibit downstream signaling

Go back
897.0, 357.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17307033,15961631,16043704 The TLR3 ectodomain senses dsRNA both extracellularly and in endosomes, and its structure has been solved recently

Go back
461.0, 393.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m18*m41844*0.1

nodelay

--

true

0

false

PMID: 17307033,17038589 The Pichlmair study also demonstrated that the IAV NS1 protein, which was thought to block IFN induction by sequestering dsRNA, instead blocks by forming a complex with RIG-I to abrogate RIG-I signaling

Go back
1045.0, 273.4782686447068

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 341.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 403.04966975222464

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.1117762963229, 410.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.9344220762334, 438.02222615706074

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 444.7060336747495

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.3831679663458, 465.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.0, 532.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0455126623185, 445.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.8442155145995, 541.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 461.6379617782631

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.0, 256.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 470.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 544.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.0, 672.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 646.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.6625609418811, 714.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.0, 404.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 422.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.8161052203985, 414.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.0, 843.0609673153948

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
902.0, 840.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.0343357322942, 262.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 485.0

c30

c30

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
743.0, 921.3474977942104

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
902.0, 916.2498780190218

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 460.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.0, 874.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
179.8, 934.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 645.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
119.0, 1017.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.40625482143932, 1030.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 374.43105262456544

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 1069.5998128235785

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
399.0, 927.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.87913857256365, 1035.3853430457254

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.620777861262, 341.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
469.78668248089167, 889.9612267066237

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 738.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
399.0, 881.8141043230231

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.46402011135336, 882.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
217.16274885206536, 932.5630084033351

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
225.98858577206613, 1021.4271971001104

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.6626102817692, 332.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.3531602401445, 263.15135438863337

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.3721553979109, 378.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.0, 256.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 717.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.67375339717, 263.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back