1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17395581.csml convertedTime:2009.07.01.11:02

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors and Type I interferons.
Authors Uematsu S, Akira S.
Affiliation Department of Host Defense, Research Institute for Microbial Diseases, OsakaUniversity and ERATO, Japan Science and Technology Corporation, 3-1 Yamada-oka,Suita Osaka 565-0871, Japan.
Abstract Toll-like receptors (TLRs) are key molecules of the innate immune systems, whichdetect conserved structures found in a broad range of pathogens and triggerinnate immune responses. A subset of TLRs recognizes viral components andinduces antiviral responses. Whereas TLR4 recognizes viral components at thecell surface, TLR3, TLR7, TLR8, and TLR9 recognize viral nucleic acids onendosomal membrane. After ligand recognition, these members activate theirintrinsic signaling pathways and induce type I interferon. In this review, wediscuss the recent findings of the viral recognition by TLRs and their signalingpathways.
PMID 17395581
Model Abstract

Entity

G010514:iNOS MO000000058:NF-kappaB{active} MO000000065:RIP1 MO000000085:Src MO000000210:IKK-alpha MO000000212:TRAF6 MO000000248:IKK MO000000276:AP-1 MO000007685:IRF-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016645:PKCepsilon MO000016882:LPS MO000016894:MAPK MO000016962:TRAF1 MO000016964:TRAF4 MO000017197:Pin1 MO000018132:CD14 MO000019398:TLR3 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11:IFN:IFNAR1:IFNAR2 e12:STAT1:STAT2:IRF9 e13:STAT1:STAT2:IRF9{active} e14:STAT1:STAT2:IRF9{active} e15:IFN inducible genes e16:TLR4:MD2 e17:LPS:TLR4:MD2 e18:fusion protein e19:fusion protein:TLR4:MD2 e2: e20:envelope protein e21:envelope protein:TLR4:MD2 e22:LPS:TLR4:MD2:TIRAP e23:LPS:TLR4:MD2:TIRAP:MYD88 e24:LPS:TLR4:MD2:TIRAP:MYD88:IRAK4 e25:IRAK1 e26:LPS:TLR4:MD2:MyD88:IRAK4:IRAK1 e27:LPS:TLR4:MD2:MyD88:IRAK4:IRAK1:TRAF6 e28:LPS:TLR4:MD2:MyD88:IRAK1:IRAK4:TRAF6{ub} e29:IRAK1:TRAF6{ub} e3: e30:TAK1:TAB1:TAB2 e31:IRAK1:TRAF6{ub}:TAK1:TAB1:TAB2 e32:IRAK1:TRAF6{ub}:TAK1{active}:TAB1:TAB2 e33:IKK{active} e34:NF-kappaB:IkappaB-alpha e35:NF-kappaB:IkappaB-alpha{p} e36:NF-kappaB{active}:IkappaB-alpha{p} e37:IkappaB-alpha{p} e38:cytokines e39:AP-1{active} e4: e40:MAPK{active} e41:LPS:TLR4:MD2:TRAM e42:LPS:TLR4:MD2:TRAM{p}:TRIF e43:TLR3:CD14:c-Src:dsRNA e44:LPS:TLR4:MD2:TRAM{p} e45:LPS:TLR4:MD2:TRAM{p}:TRIF:RIP1 e46:LPS:TLR4:MD2:TRAM{p}:TRIF:TRAF6 e47:CpG DNA e48:TBK1:IKK-i:NAP1:TRAF3 e49:e49 e5:IFNAR1:IFNAR2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFN e60: e61: e62: e63:IRF-3{p} e64:DNA e65:DNA:IRF3{p} e66: e67: e68: e69:TLR3:CD14:c-Src e7: e70:TLR3:CD14:c-Src:dsRNA:TRIF e71:TLR3:CD14:c-Src:dsRNA:TRIF:RIP1 e72:TBK1:IKK-i:NAP1:TRAF3:TLR3:CD14:c-Src:dsRNA:TRIF e73:IFN-beta e74:TLR3:CD14:c-Src:dsRNA:TRIF:TRAF1:TRAF6 e75:TLR3:CD14:c-Src:dsRNA:TRIF:RIP1:TRAF6 e76:CpG DNA:TLR9 e77:IFN-alpha e78:IFN-alpha e79:ssRNA e8: e80:ssRNA:TLR7 e81:ssRNA:TLR8 e82:CpG DNA:TLR9:MYD88 e83:ssRNA:TLR7:MYD88 e84:type I IFNs e85:CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6:IRF7 e86:CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6:IRF7{p} e87:CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6 e88:CpG DNA:TLR9:MYD88:IRF1 e89:IRF-1 e9: e90:IL-12 p35

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p7 p8 p9
Model Detail
846.0, 1430.0
36.0, 36.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
817.0, 1093.0
30.0, 30.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
395.0, 703.0
34.0, 34.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p36

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1051.0, 427.0
34.0, 34.0

Src

--

MO000000085

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
1220.0, 992.0
32.0, 32.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
468.0, 304.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p28 p41 p52

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
770.0, 462.0
36.0, 36.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
941.0, 805.0
30.0, 30.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1179.0, 1143.0
34.0, 34.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
791.0, 551.0
26.0, 26.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30 p38

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1229.0, 773.0
38.0, 38.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
670.0, 262.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p48 p49

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
379.0, 603.0
26.0, 26.0

PKCepsilon

--

MO000016645

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1629

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016645

--

Go back
846.0, 62.0
20.0, 20.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
535.0, 855.0
34.0, 34.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
1221.0, 529.0
30.0, 30.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
1223.0, 643.0
26.0, 26.0

TRAF4

--

MO000016964

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m1873

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016964

--

Go back
854.0, 534.0
28.0, 28.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
1076.0, 468.0
32.0, 32.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1040.0, 352.0
32.0, 32.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1209.0, 357.0
22.0, 22.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
741.0, 249.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
588.0, 240.0
31.0, 31.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p52

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
855.0, 303.0
34.0, 34.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p35

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1009.0, 181.0
38.0, 38.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
869.0, 737.0
30.0, 30.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p38

p31

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
958.0, 1334.0
36.0, 36.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
978.0, 662.0
28.0, 28.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
1086.0, 666.0
27.0, 27.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
954.0, 642.0
28.0, 28.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
303.1886080565258, 162.91805323822402
1042.4592739663965, 1513.6508657992056

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
311.2326305771379, 177.05350583430697
1010.4622651083632, 1421.4362806100105

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
340.5, 1068.996491997369
22.73514580135935, 44.003508002631

IFN:IFNAR1:IFNAR2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
570.5, 599.3037254542119
24.86566342448156, 34.69627454578822

STAT1:STAT2:IRF9

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
581.5, 737.194714626537
20.643787850981827, 28.80528537346302

STAT1:STAT2:IRF9{active}

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
713.5, 1101.194714626537
20.643787850981827, 28.80528537346302

STAT1:STAT2:IRF9{active}

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
696.0, 1335.5882352941178
47.64705882352941, 25.41176470588235

IFN inducible genes

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
852.0, 190.26519337016583
24.961325966850836, 27.734806629834257

TLR4:MD2

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p6 p7 p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
795.5, 186.71113965865294
24.57368324463204, 34.28886034134703

LPS:TLR4:MD2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p9 p24

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
899.0, 46.35764499121268
41.75746924428823, 27.14235500878735

fusion protein

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
909.5, 179.6930497697873
20.825257618943215, 40.30695023021267

fusion protein:TLR4:MD2

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
303.1886080565258, 162.91805323822402
1042.4592739663965, 1513.6508657992056

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1000.0, 52.33719058160597
39.18293419199034, 24.16280941839404

envelope protein

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
961.5, 180.7059855294891
20.301907476430607, 39.29401447051086

envelope protein:TLR4:MD2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
705.0, 173.67647058823525
21.794117647058826, 36.32352941176471

LPS:TLR4:MD2:TIRAP

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
623.0, 181.4411764705883
26.735294117647058, 44.55882352941177

LPS:TLR4:MD2:TIRAP:MYD88

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
550.0, 181.26470588235304
27.441176470588232, 45.735294117647065

LPS:TLR4:MD2:TIRAP:MYD88:IRAK4

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11 p15

p12

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
503.0, 247.45999999999992
34.72, 26.040000000000003

IRAK1

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p12 p52

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
450.0, 180.9411764705883
28.23529411764706, 47.058823529411775

LPS:TLR4:MD2:MyD88:IRAK4:IRAK1

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
354.0, 184.79411764705884
28.323529411764703, 47.20588235294118

LPS:TLR4:MD2:MyD88:IRAK4:IRAK1:TRAF6

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
325.0, 247.61764705882354
29.029411764705877, 48.38235294117648

LPS:TLR4:MD2:MyD88:IRAK1:IRAK4:TRAF6{ub}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
393.5, 334.5557407098817
28.12947842026329, 34.44425929011831

IRAK1:TRAF6{ub}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
324.03779353585355, 183.76723871755195
1000.7609030077406, 1471.952494840551

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
491.5, 394.4999082400441
25.441732427968432, 35.50009175995596

TAK1:TAB1:TAB2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
425.0, 441.67647058823536
21.794117647058826, 36.32352941176471

IRAK1:TRAF6{ub}:TAK1:TAB1:TAB2

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
395.0, 558.7647058823529
25.941176470588232, 43.23529411764706

IRAK1:TRAF6{ub}:TAK1{active}:TAB1:TAB2

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18 p23

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
674.0, 518.0
36.0, 36.0

IKK{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19 p22

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
711.0, 672.6022099447513
34.55801104972376, 38.39779005524862

NF-kappaB:IkappaB-alpha

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
795.0, 772.6022099447513
34.55801104972376, 38.39779005524862

NF-kappaB:IkappaB-alpha{p}

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p42

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
993.0, 953.0
30.0, 30.0

NF-kappaB{active}:IkappaB-alpha{p}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p20

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
706.5, 793.5252565908634
18.176091768967602, 29.47474340913665

IkappaB-alpha{p}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
793.0, 1289.3771626297578
53.667820069204154, 28.622837370242216

cytokines

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
933.0, 993.0
30.0, 30.0

AP-1{active}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
362.6087866726105, 220.25331330637556
923.6189167342274, 1398.9803456629024

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
475.0, 1019.0
34.0, 34.0

MAPK{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
335.0, 471.08823529411757
25.147058823529417, 41.911764705882355

LPS:TLR4:MD2:TRAM

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p26

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
330.0, 636.9411764705883
28.235294117647054, 47.05882352941177

LPS:TLR4:MD2:TRAM{p}:TRIF

--

e42

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

p27 p29

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1149.0, 441.4999999999999
22.5, 37.49999999999999

TLR3:CD14:c-Src:dsRNA

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p34

p35

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
326.0, 537.4117647058824
27.35294117647059, 45.588235294117645

LPS:TLR4:MD2:TRAM{p}

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p25

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
327.0, 746.1764705882354
26.294117647058822, 43.82352941176471

LPS:TLR4:MD2:TRAM{p}:TRIF:RIP1

--

e45

cso30:c:Complex

cso30:i:CC_Extracellular

--

p27

p28

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
327.0, 818.029411764706
26.382352941176467, 43.97058823529412

LPS:TLR4:MD2:TRAM{p}:TRIF:TRAF6

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1206.0, 745.5
60.0, 13.0

CpG DNA

--

e47

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
910.0, 372.9411764705883
28.235294117647054, 47.05882352941177

TBK1:IKK-i:NAP1:TRAF3

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p29 p37

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
817.0, 458.85294117647055
30.08823529411765, 50.14705882352941

e49

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
336.5, 995.7434094903339
30.066783831282955, 46.256590509666076

IFNAR1:IFNAR2

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
516.8527391911847, 1038.8386839418488
566.909066617741, 514.1242373237245

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
578.0831411722444, 1051.0226809473436
331.4887279664261, 498.2887885355195

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
524.2426152923471, 1045.7007117500707
552.1293144154167, 500.40018170728

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
525.2983118782274, 1046.756408335951
550.0179212436558, 498.2887885355195

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
516.8527391911847, 1038.8386839418488
566.909066617741, 514.1242373237245

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
516.8527391911847, 1038.8386839418488
566.909066617741, 514.1242373237245

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
525.2983118782274, 1046.756408335951
550.0179212436558, 498.2887885355195

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
930.6858008562765, 1249.978001117916
35.417363598100415, 32.06203441512252

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
837.7845012988071, 1397.7755231411647
100.29117565863197, 90.78990638570909

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
516.8527391911847, 1038.8386839418488
566.909066617741, 514.1242373237245

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
169.0, 902.4824253075572
38.488576449912124, 25.017574692442878

IFN

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
650.4700164152255, 1267.3112467649653
17.95317715441047, 8.64412233360505

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
649.8705090121069, 1241.5324284308733
61.44950881963848, 110.60911587534923

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
675.6493273461998, 1313.4733168050846
9.592118449894775, 9.592118449894777

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
889.0, 1101.0
30.0, 30.0

IRF-3{p}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p32

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
846.0, 1165.5
60.0, 13.0

DNA

--

e64

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p32

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
930.0, 1195.5
60.0, 17.0

DNA:IRF3{p}

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p32

p39

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
963.0, 356.4408055676711
209.82576375324734, 350.3023344016078

--

e66

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
963.0, 356.4408055676711
209.82576375324734, 350.3023344016078

--

e67

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false true false

--

Go back
963.0, 356.4408055676711
209.82576375324734, 350.3023344016078

--

e68

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false true false

--

Go back
1122.5, 400.52688566709503
27.572398605248672, 38.473114332905126

TLR3:CD14:c-Src

--

e69

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p33

p34

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
309.88500240281473, 172.00910398114718
1022.327770960083, 1448.6120444600426

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1158.0, 492.38235294117646
27.97058823529412, 46.61764705882353

TLR3:CD14:c-Src:dsRNA:TRIF

--

e70

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p35

p36 p37 p40

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1012.0, 339.26470588235304
24.44117647058824, 40.735294117647065

TLR3:CD14:c-Src:dsRNA:TRIF:RIP1

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p41

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1157.0, 549.2058823529412
22.676470588235297, 37.794117647058826

TBK1:IKK-i:NAP1:TRAF3:TLR3:CD14:c-Src:dsRNA:TRIF

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
912.0, 1377.1591695501731
40.9515570934256, 21.84083044982699

IFN-beta

--

e73

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p39 p58

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1148.0, 592.5882352941177
23.647058823529413, 39.411764705882355

TLR3:CD14:c-Src:dsRNA:TRIF:TRAF1:TRAF6

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
975.0, 350.9117647058823
25.852941176470587, 43.088235294117645

TLR3:CD14:c-Src:dsRNA:TRIF:RIP1:TRAF6

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1054.5, 681.2319666739751
19.513483885112915, 37.76803332602499

CpG DNA:TLR9

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44 p45 p48

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
988.0, 1308.7439446366784
56.73010380622837, 30.256055363321803

IFN-alpha

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

p45

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1174.0, 1352.4309720265646
42.27409941638157, 26.0690279734353

IFN-alpha

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
872.0, 463.4335672001755
48.51567638675729, 25.0664327998246

ssRNA

--

e79

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p46 p47

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
313.537374228492, 197.57570676088707
980.7312125049692, 1424.0217205572144

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
953.5, 567.3247094935322
21.01556676167507, 40.67529050646788

ssRNA:TLR7

--

e80

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

p49

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1006.5, 684.6663012497261
19.805744354308267, 38.33369875027407

ssRNA:TLR8

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
961.5, 513.0385391815012
21.472380253257477, 29.961460818498804

CpG DNA:TLR9:MYD88

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48 p57

p51 p52 p56

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
955.5, 470.413837401358
24.786749862360068, 34.586162598641955

ssRNA:TLR7:MYD88

--

e83

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

p50

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
758.0, 1424.0
60.0, 32.0

type I IFNs

--

e84

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50 p51

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1120.4117647058824, 628.735294117647
23.55882352941177, 39.26470588235295

CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6:IRF7

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p53 p55

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
953.0, 437.3529411764706
22.58823529411764, 37.64705882352941

CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6:IRF7{p}

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53 p55

p54

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
953.0, 386.8529411764705
30.08823529411765, 50.14705882352941

CPG DNA:TLR9:MYD88:IRAK1:IRAK4:TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1095.0, 354.4705882352939
26.11764705882353, 43.529411764705884

CpG DNA:TLR9:MYD88:IRF1

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
863.0, 1243.0
25.0, 25.0

IRF-1

--

e89

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

p58 p59 p60

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
323.27703243029765, 223.1423095406268
976.2536365550839, 1405.3460325196638

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
705.0, 1489.3771626297578
53.667820069204154, 28.622837370242216

IL-12 p35

--

e90

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
214.0, 985.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 17395581 Type I IFNs are the key cytokines that mediate antiviral responses. Secreted IFNs bind and activate the type I IFN receptor (a heterodimer of IFNAR1 and IFNAR2) in an autocrine and paracrine manner.

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668.0, 100.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 17395581 A TIR domain-containing adapter, MyD88, associates with the cytoplasmic TIR domain of TLRs and recruits IRAKs to the receptor upon ligand binding.

Go back
592.0, 92.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m17258*m23*0.1

nodelay

--

true

0

false

PMID: 17395581 The association of TLRs with MyD88, which is utilized by all TLRs except TLR3, recruits IL-1R-associated kinase (IRAK)-1 and IRAK-4 and tumor necrosis factor receptor-associated factor 6 (TRAF6).

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508.0, 100.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m24*m25*0.1

nodelay

--

true

0

false

PMID: 17395581 The association of TLRs with MyD88, which is utilized by all TLRs except TLR3, recruits IL-1R-associated kinase (IRAK)-1 and IRAK-4 and tumor necrosis factor receptor-associated factor 6 (TRAF6).

Go back
389.0, 101.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000000212

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m26*m183*0.1

nodelay

--

true

0

false

PMID: 17395581 The association of TLRs with MyD88, which is utilized by all TLRs except TLR3, recruits IL-1R-associated kinase (IRAK)-1 and IRAK-4 and tumor necrosis factor receptor-associated factor 6 (TRAF6).

Go back
406.0, 306.0
19.0, 19.0

p14

p14

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17395581 IRAKs then activate TRAF6, leading to the activation of TAK1.

Go back
248.0, 340.0
23.0, 23.0

p15

p15

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e28

e29 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17395581 IRAK-1 and TRAF6 then dissociate from this receptor complex and associate with another complex composed of transforming growth factor-beta-activated kinase (TAK1) and TAK1-binding proteins 1 (Tab1) and 2.

Go back
243.0, 391.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m29*m30*0.1

nodelay

--

true

0

false

PMID: 17395581 IRAK-1 and TRAF6 then dissociate from this receptor complex and associate with another complex composed of transforming growth factor-beta-activated kinase (TAK1) and TAK1-binding proteins 1 (Tab1) and 2.

Go back
398.0, 502.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17395581 This complex formation leads to the activation of TAK1.

Go back
681.0, 425.0
21.0, 21.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m207*m32*0.1

nodelay

--

true

0

false

PMID: 17395581 TAK1 activates the IKK complex consisting of IKK{alpha}, IKKbeta, and NEMO/IKK{gamma}.

Go back
774.0, 726.0
19.0, 19.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 17395581 The IKK complex phosphorylates I{kappa}B, resulting in nuclear translocation of NF-{kappa}B, which induces expression of inflammatory cytokines.

Go back
526.0, 698.0
19.0, 19.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e12 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c8 : 1
stoichiometry:c5 : 1

m12*m11*0.1

nodelay

--

true

0

false

PMID: 17395581, 16497588 This binding leads to the activation of IFN-stimulated gene factor 3 (ISGF3; a heterotrimer of signal transducer and activator of transcription 1 (STAT1), STAT2, and IFN regulatory factor 9 (IRF9)), which translocates to the nucleus and induces the transcription of hundreds of effector molecules, called IFN-inducible genes.

Go back
752.0, 904.0
23.0, 23.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e36

e37 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17395581 The IKK complex phosphorylates I{kappa}B, resulting in nuclear translocation of NF-{kappa}B, which induces expression of inflammatory cytokines.

Go back
808.0, 1200.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17395581 The IKK complex phosphorylates I{kappa}B, resulting in nuclear translocation of NF-{kappa}B, which induces expression of inflammatory cytokines.

Go back
949.0, 878.0
21.0, 21.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000276 e33

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c58 : 1

m219*m33*0.1

nodelay

--

true

0

false

PMID: 17395581 This complex formation leads to the activation of TAK1, which in turn activates the transcription factors nuclear factor-{kappa}B (NF-{kappa}B) and activator protein 1 (AP-1) through the canonical I{kappa}B kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

Go back
481.0, 941.0
21.0, 21.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000016894

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m32*m1812*0.1

nodelay

--

true

0

false

PMID: 17395581 This complex formation leads to the activation of TAK1, which in turn activates the transcription factors nuclear factor-{kappa}B (NF-{kappa}B) and activator protein 1 (AP-1) through the canonical I{kappa}B kinase (IKK) complex and the mitogen-activated protein kinase pathway, respectively.

Go back
241.0, 477.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e17

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m19005*m17*0.1

nodelay

--

true

0

false

PMID: 17395581 TLR4 also requires another adapter, TRAM, for IRF3 activation. PMID: 17395581 The N terminus of TRAM has a myristoylation site, mutation of which alters its normal membrane localization and abolishes TLR4 signaling, suggesting that TRAM acts as a bridging adapter between TLR4 and TRIF

Go back
189.0, 621.0
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041125 e44

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c70 : 1
stoichiometry:c68 : 1

m18998*m44*0.1

nodelay

--

true

0

false

PMID: 17395581 TLR4 also requires another adapter, TRAM, for IRF3 activation.A TIR domain-containing adapter, TRIF, is responsible for TLR3- and TLR4-mediated IRF3 activation

Go back
207.0, 522.5
18.5, 18.5

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 MO000016645

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c71 : 1
stoichiometry:c69 : 1

m41*m1629*0.1

nodelay

--

true

0

false

PMID: 17395581, 16757566 It has also been reported that phosphorylation of TRAM by PKC{epsilon} is crucial for the activation of IRF3 and the induction of IFN-inducible genes.

Go back
198.0, 710.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 MO000000065

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m42*m45*0.1

nodelay

--

true

0

false

PMID: 17395581, 15064760 Receptor-interacting protein-1 (RIP1) binds the C terminus of TRIF via a Rip homotypic interaction motif and mediates the TLR3-mediated NF-{kappa}B but not IRF3 activation.

Go back
214.0, 806.5
19.5, 19.5

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1

m183*m46*0.1

nodelay

--

true

0

false

PMID: 17395581 TRAF6 binds the N terminus of TRIF and cooperatively activates NF-kappaB.

Go back
822.0, 386.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e42

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m63*m42*0.1

nodelay

--

true

0

false

PMID: 17395581 TRIF interacts with TBK1, IKK{iota}, RIP1, and TRAF6.

Go back
630.0, 954.0
19.0, 19.0

p3

p3

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17395581, 16497588 This binding leads to the activation of IFN-stimulated gene factor 3 (ISGF3; a heterotrimer of signal transducer and activator of transcription 1 (STAT1), STAT2, and IFN regulatory factor 9 (IRF9)), which translocates to the nucleus and induces the transcription of hundreds of effector molecules, called IFN-inducible genes.

Go back
799.0, 659.0
17.0, 17.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e49

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m977*m64*0.1

nodelay

--

true

0

false

PMID: 17395581 IRF3 is activated by TBK1 and IKK{iota}, which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
846.0, 866.0
19.0, 19.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17395581 IRF3 is activated by TBK1 and IKK{iota}, which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
945.0, 1137.0
21.0, 21.0

p32

p32

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e63 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m65*m66*0.1

nodelay

--

true

0

false

PMID: 17395581 IRF3 is activated by TBK1 and IKK{iota}, which catalyze IRF3 phosphorylation and stimulate its nuclear translocation and DNA binding.

Go back
1162.0, 310.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000000085 MO000018132

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m3965*m77*m2828*0.1

nodelay

--

true

0

false

PMID: 17395581, 16473828, 16858407 TLR3 interacts with CD14 and c-Src for ligand uptake and signal transduction.

Go back
1194.0, 434.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e69

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m119368*m71*0.1

nodelay

--

true

0

false

PMID: 17395581, 16497588 TLR3 recognizes a synthetic analog of viral dsRNA, polyinosinic acid-cytidylic acid (poly(I?C)), and viral dsRNAs derived from dsRNA viruses such as reovirus or ssRNA viruses such as West Nile virus, respiratory syncytial virus, and encephalomyocarditis virus.

Go back
1218.0, 473.5
20.5, 20.5

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000041125

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m43*m18998*0.1

nodelay

--

true

0

false

PMID: 17395581, 12872135, 12855817 TLR3 signaling activates the transcription factors interferon regulatory factor 3 (IRF3) and NF-{kappa}B via the adapter molecule TRIF.

Go back
1067.0, 527.0
17.0, 17.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e70 MO000000065

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m72*m45*0.1

nodelay

--

true

0

false

PMID: 17395581, 15064760 Receptor-interacting protein-1 (RIP1) binds the C terminus of TRIF via a Rip homotypic interaction motif and mediates the TLR3-mediated NF-{kappa}B but not IRF3 activation.

Go back
1014.0, 450.0
19.0, 19.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m63*m72*0.1

nodelay

--

true

0

false

PMID: 17395581, 16306936, 16306937, 15611223, 12702806 TRIF interacts with noncanonical IKKs TBK1 (also called NAK or T2K) and IKK{iota} (also called IKK{epsilon}) through TRAF3 and NAK-associated protein 1 (NAP1), which mediate phosphorylation of IRF3.

Go back
859.0, 647.0
17.0, 17.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e72 MO000017197

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c114 : 1
stoichiometry:c106 : 1

m977*m74*0.1

nodelay

--

true

0

false

PMID: 17395581, 16306936, 16306937, 15611223, 12702806 TRIF interacts with noncanonical IKKs TBK1 (also called NAK or T2K) and IKK{iota} (also called IKK{epsilon}) through TRAF3 and NAK-associated protein 1 (NAP1), which mediate phosphorylation of IRF3. PMID: 17395581, 16699525 IRF3 activation is negatively regulated by the peptidyl-prolyl isomerase Pin1.

Go back
908.0, 1268.0
23.0, 23.0

p39

p39

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e65

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17395581 Activated IRF3 translocates into the nucleus and induces expression of IFN-beta.

Go back
707.0, 1203.0
25.0, 25.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17395581, 16497588 This binding leads to the activation of IFN-stimulated gene factor 3 (ISGF3; a heterotrimer of signal transducer and activator of transcription 1 (STAT1), STAT2, and IFN regulatory factor 9 (IRF9)), which translocates to the nucleus and induces the transcription of hundreds of effector molecules, called IFN-inducible genes.

Go back
1194.0, 594.0
19.0, 19.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016962 MO000016964 e70

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c110 : 1
stoichiometry:c113 : 1

m1871*m1873*m72*0.1

nodelay

--

true

0

false

PMID: 17395581, 16323247, 16052631 TRAF1 and TRAF4 interact with TRIF and negatively regulate TRIF-mediated signaling pathways.

Go back
922.0, 262.0
19.0, 19.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000000212

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m73*m183*0.1

nodelay

--

true

0

false

PMID: 17395581, 14530355 TRAF6 binds the N terminus of TRIF and cooperatively activates NF-{kappa}B.

Go back
1048.0, 876.0
15.0, 15.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 e75

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m35*m78*0.1

nodelay

--

true

0

false

PMID: 17395581, 14530355 TRAF6 binds the N terminus of TRIF and cooperatively activates NF-{kappa}B.

Go back
1190.0, 710.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e47

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m19828*m49*0.1

nodelay

--

true

0

false

PMID: 17395581, 11130078 TLR9 mediates the recognition of CpG DNA.

Go back
1005.0, 1245.0
21.0, 21.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17395581, 12900525 Mouse pDCs produce IFN-{alpha} by recognizing the CpG-containing DNA of herpes simplex virus type 2 (HSV-2) via TLR9.

Go back
1133.0, 1229.0
21.0, 21.0

p45

p45

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e77 e76

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c126 : 1

m80*m79*0.1

nodelay

--

true

0

false

--

Go back
892.0, 520.0
23.0, 23.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m19940*m82*0.1

nodelay

--

true

0

false

PMID: 17395581, 14976261, 14976262 TLR7 and human TLR8 have been shown to recognize guanosine- or uridine-rich ssRNA from viruses such as human immunodeficiency virus, vesicular stomatitis virus, and influenza virus

Go back
985.0, 753.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e79

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m19823*m82*0.1

nodelay

--

true

0

false

PMID: 17395581, 14976261, 14976262 TLR7 and human TLR8 have been shown to recognize guanosine- or uridine-rich ssRNA from viruses such as human immunodeficiency virus, vesicular stomatitis virus, and influenza virus.

Go back
1101.0, 281.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e76

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m1572*m79*0.1

nodelay

--

true

0

false

PMID: 17395581, 12626561 The induction of type I IFNs by TLR7 and TLR9 depends entirely on MyD88 in pDCs.

Go back
914.0, 498.0
19.0, 19.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e80 MO000016573

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m83*m1572*0.1

nodelay

--

true

0

false

PMID: 17395581, 12626561 The induction of type I IFNs by TLR7 and TLR9 depends entirely on MyD88 in pDCs.

Go back
227.0, 1335.0
25.0, 25.0

p5

p5

cso30:i:CE_CellGrowth

cso30:i:CC_Extracellular

--

e15

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17395581 These effector molecules directly influence protein synthesis, cell growth, and survival, in the process of establishing an antiviral state.

Go back
741.0, 1349.0
21.0, 21.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 17395581, 12626561 The induction of type I IFNs by TLR7 and TLR9 depends entirely on MyD88 in pDCs.

Go back
812.0, 1360.0
23.0, 23.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e82

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 17395581, 12626561 The induction of type I IFNs by TLR7 and TLR9 depends entirely on MyD88 in pDCs.

Go back
1205.0, 833.0
21.0, 21.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e82 MO000000212 e25 MO000039077 MO000007702

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m85*m183*m25*m17258*m980*0.1

nodelay

--

true

0

false

PMID: 17395581 IRF7 is activated through forming a signaling complex with MyD88, IRAKs, and TRAF6 in the cytoplasm. PMID: 17395581, 15361868, 15492225 IRF7 forms a signaling complex with MyD88 and TRAF6 in the cytoplasm.

Go back
1181.0, 881.0
21.0, 21.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m88*0.1

nodelay

--

true

0

false

PMID: 17395581, 15361868, 15492225, 17056502 After ligand stimulation, IRF7 is activated by its phosphorylation in TBK1/IKK{iota}-independent manner and translocates into the nucleus to induce the expression of type I IFNs. PMID: 17395581, 15767370 IRAK-1, but not IRAK-4, can directly bind and phosphorylate IRF7; thus, IRAK-1 specifically mediates IFN-{alpha} induction downstream of MyD88 and IRAK-4

Go back
656.0, 604.0
23.0, 23.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e86

MO000041457 e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 17395581, 15361868, 15492225, 17056502 After ligand stimulation, IRF7 is activated by its phosphorylation in TBK1/IKK{iota}-independent manner and translocates into the nucleus to induce the expression of type I IFNs.

Go back
1140.0, 876.0
23.0, 23.0

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85 MO000000210

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c158 : 1
stoichiometry:c157 : 1

m88*m181*0.1

nodelay

--

true

0

false

PMID: 17395581, 16612387 In addition to IRAKs, IKK{alpha} has been shown to be essential for the phosphorylation of IRF7, suggesting that the IRAK-4/IRAK-1/IKK{alpha} kinase cascade might lead to the full activation of IRF7.

Go back
1166.0, 1058.0
19.0, 19.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e82 MO000007685

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m85*m970*0.1

nodelay

--

true

0

false

PMID: 17395581, 17018642 After ligand stimulation, IRF1 interacts with MyD88, is activated by an unknown mechanism, and translocates into the nucleus to induce the expression of IFN-beta, inducible nitric-oxide synthase, and IL-12 p35.

Go back
1074.0, 1030.0
19.0, 19.0

p57

p57

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e88

e89 e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 17395581, 17018642 After ligand stimulation, IRF1 interacts with MyD88, is activated by an unknown mechanism, and translocates into the nucleus to induce the expression of IFN-beta, inducible nitric-oxide synthase, and IL-12 p35.

Go back
875.0, 1327.0
17.0, 17.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e89

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m92*0.1

nodelay

--

true

0

false

MID: 17395581, 17018642 After ligand stimulation, IRF1 interacts with MyD88, is activated by an unknown mechanism, and translocates into the nucleus to induce the expression of IFN-beta, inducible nitric-oxide synthase, and IL-12 p35.

Go back
848.0, 1384.0
23.0, 23.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e89

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c167 : 1

m92*0.1

nodelay

--

true

0

false

MID: 17395581, 17018642 After ligand stimulation, IRF1 interacts with MyD88, is activated by an unknown mechanism, and translocates into the nucleus to induce the expression of IFN-beta, inducible nitric-oxide synthase, and IL-12 p35.

Go back
838.0, 110.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016882

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m16*m155666*0.1

nodelay

--

true

0

false

PMID: 17395581, 9851930, 10201887 TLR4, the first mammalian homologue of the Drosophila Toll protein recognizes lipopolysaccharide (LPS), which is a cell wall component of Gram-negative bacteria

Go back
945.0, 1442.0
21.0, 21.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c169 : 1

m92*0.1

nodelay

--

true

0

false

MID: 17395581, 17018642 After ligand stimulation, IRF1 interacts with MyD88, is activated by an unknown mechanism, and translocates into the nucleus to induce the expression of IFN-beta, inducible nitric-oxide synthase, and IL-12 p35.

Go back
910.0, 110.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e16

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c15 : 1

m18*m16*0.1

nodelay

--

true

0

false

PMID: 17395581, 11062499, 11854525 TLR4 recognizes not only bacterial components but also viral proteins, such as the fusion (F) protein from respiratory syncytial virus and the envelope protein of mouse mammary tumor virus.

Go back
976.0, 109.5
17.5, 17.5

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m16*m20*0.1

nodelay

--

true

0

false

PMID: 17395581, 11062499, 11854525 TLR4 recognizes not only bacterial components but also viral proteins, such as the fusion (F) protein from respiratory syncytial virus and the envelope protein of mouse mammary tumor virus.

Go back
746.0, 114.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000022528

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m17*m6810*0.1

nodelay

--

true

0

false

PMID: 17395581, 16497588 Each TLR mediates distinctive responses in association with a different combination of four TIR domain-containing adapters (MyD88, TIRAP/MAL, TRIF, and TRAM) through the homophilic interaction of TIR domains.

Go back
194.0, 928.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.0, 1228.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
429.0, 540.1386580688023

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.246016547503, 387.6782426158818

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.0, 405.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1040.4683036326853, 465.86782859495116

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 467.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.0, 577.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 664.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.6723102640221, 571.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
929.7312732965926, 1213.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.0, 1291.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.0, 1348.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1180.0, 539.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1212.816734903234, 559.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1214.1159660434203, 619.8599434057004

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.8709592807993, 606.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 562.0

c114

c114

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
946.7775991412111, 286.533475233836

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 273.84827133858363

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 281.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.0, 799.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.932754944306, 891.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.419724221888, 136.87301613956078

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.0, 394.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1113.0, 685.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1214.9463531699773, 733.3517178529796

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.9154498946862, 702.1600228293936

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.0, 1266.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.6819197004643, 719.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1148.0, 1250.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.0, 1251.4047579666174

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1067.0, 719.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.6636527173945, 550.1117964514128

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.1313708498985, 82.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 489.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 542.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.0, 690.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 489.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 730.5894663844041

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.0, 272.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 309.94419872680396

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.077524930242, 302.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.5777087639997, 524.1554175279994

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 282.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.4779925266494, 129.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0, 497.1898088913156

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1370.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.9229610715615, 505.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
799.7825416385168, 1383.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.379276620446, 543.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
983.0, 542.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 331.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 273.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 270.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1227.2950039375453, 811.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 129.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1144.1243987748494, 675.364654255002

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1137.0, 668.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.7029155490956, 482.09143260817353

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.0388135260721, 462.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 627.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 426.5096873731505

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1134.0, 668.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.1998349188976, 482.3321931570168

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.5829655347882, 905.5571660728507

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
978.0, 543.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 74.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.6600336668405, 1084.8258730008195

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.7840854374906, 405.9614829037507

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1084.2909466383526, 398.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.5371719719666, 1049.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.7167516775556, 550.8136267941085

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.0, 1344.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.0, 1268.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
861.0, 1407.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.9585612815268, 1268.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.8035280165417, 1456.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 135.63960941473997

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 1268.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.0, 128.66232047149825

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.2950039375453, 77.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
240.86974573384438, 998.4377420090677

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.3151918984429, 127.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.3511636339965, 139.71322389245182

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 141.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.0414336125515, 133.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.2888620248546, 130.29269405511226

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 131.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.4779925266494, 123.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 123.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.4256292582156, 122.62340624010609

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.029062765764, 115.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
233.0, 1002.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.4779925266494, 130.20441309091663

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 131.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.13331974307533, 123.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.55919167198687, 128.5737182247253

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.01320066347097, 129.41084487502323

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.5298221281347, 122.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
379.0, 232.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.9294846883888, 283.9977796279166

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.65685424949237, 287.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 352.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.6663130655601, 634.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 214.50535765770897

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.5712469231819, 357.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.9949028347804, 404.2855322440993

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.0, 408.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.810265188326, 478.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.0, 521.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.2792613278383, 444.3184867818086

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 446.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 445.5996746260179

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
746.0, 706.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 715.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 745.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 554.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.8203132918, 919.6860308473147

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 927.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.2491077284276, 830.3104923889621

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 1223.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.9287423733235, 1123.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
957.0, 835.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.7624706187336, 899.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 554.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
595.0, 766.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 602.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.8, 889.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 962.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
269.50089937229524, 207.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.12311704571044, 210.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 488.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
217.25806598406976, 328.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
233.65678578404746, 496.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.0, 634.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 534.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 973.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
217.10574114524758, 567.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
233.22026516856008, 540.4449631196397

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
224.3158220461108, 666.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.0, 720.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.0, 723.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.37755505462826, 773.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.7154279917321, 336.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.0, 818.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 396.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 404.80635636514285

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.0, 724.2118647163439

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.0, 405.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.0, 577.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 676.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0573097607281, 509.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.8103713256907, 767.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.0, 885.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 1125.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 1153.3861999450876

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 1158.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.0, 327.0418630172467

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.3284898516167, 1130.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.0, 335.1354944392216

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 336.18616800870984

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.7171557102204, 329.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1207.7053366017337, 379.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1150.0, 425.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.5183473879074, 448.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 464.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.0, 328.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.9726042969965, 490.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.8405438169862, 519.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back