1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17395583.csml convertedTime:2009.07.01.11:03

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Triggering the innate antiviral response through IRF-3 activation.
Authors Hiscott J.
Affiliation Lady Davis Institute for Medical Research-Jewish General Hospital, Departmentsof Microbiology & Immunology, Medicine, and Oncology, McGill University,Montreal H3T 1E2, Canada. john.hiscott@mcgill.ca
Abstract Rapid induction of type I interferon (IFN) expression is a central event in theestablishment of the innate immune response against viral infection and requiresthe activation of multiple transcriptional proteins following engagement andsignaling through Toll-like receptor-dependent and -independent pathways. Thetranscription factor interferon regulatory factor-3 (IRF-3) contributes to afirst line of defense against viral infection by inducing the production ofIFN-beta that in turn amplifies the IFN response and the development ofantiviral activity. In murine knock-out models, the absence of IRF-3 and theclosely related IRF-7 ablates IFN production and increases viral pathogenesis,thus supporting a pivotal role for IRF-3/IRF-7 in the development of the hostantiviral response.
PMID 17395583
Model Abstract

Entity

G010228:IFN-beta G010522:RANTES G010713:IRF-7 MO000000023:JNK MO000000212:TRAF6 MO000000248:IKK MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016608:IKK-i MO000016882:LPS MO000016963:TRAF3 MO000017197:Pin1 MO000017462:CBP MO000019331:TBK1{active} MO000019398:TLR3 MO000019479:protein remnants MO000019984:p300 MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000055971:ATF-2:c-Jun MO000066987:DDX58 MO000069094:ISG15 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e11:(IRF-3{p})2:CBP e12:(IRF-3{p})2:p300 e13:IRF-3 e14:IFN e15:IFN-alpha1 e16:IFN-alpah4 e17:IFN-alpha7 e18:IFN-alpha14 e19:cullin1 e2: e20:cullin1:IRF-3 e21:cullin1:IRF-3{ub} e22:IRF-3{p}:pin1 e23:Pin1:IRF-3{ub}n e24:IRF-3{p}:ISG15 e25:ddx58:dsRNA e26:dsRNA:IFIH1 e27:dsRNA:DDX58:MAVS e28:dsRNA:IFIH1:MAVS e29:LGP2 e3: e30:DDX58:LGP2 e31:dsRNA:DDX58:MAVS:TRAF3 e32:dsRNA:IFIH1:MAVS:TRAF3 e33:dsRNA:DDX58:MAVS:TRAF3:ikk-i e34:JNK{active} e35:IKK{active} e36:TBK1 e37:ATF-2:c-Jun{active} e38:NF-kappaB e39:NF-kappaB{active} e4: e40:IFN-beta e41:IFN-beta enhancesome complex e42:dsRNA:TLR3:TRIF:TRAF6 e43:dsRNA:TLR3:TRIF:TRAF3 e44: e45: e46: e47:dsRNA:TLR7 e48:dsRNA:TLR9 e49:dsRNA:TLR9:MYD88 e5:(IRF-3{p})2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:(IRF-3{p})2 e60: e61: e62: e63:dsRNA:TLR9:MYD88:IRAK4 e64:IRAK1 e65:dsRNA:TLR9:MYD88:IRAK4:IRAK1 e66:dsRNA:TLR9:MYD88:IRAK4:IRAK1:TRAF6 e67:IRF-7{active} e68:dsRNA:TLR7:MYD88 e69:dsRNA:TLR7:MYD88:IRAK4 e7: e70:dsRNA:TLR7:MYD88:IRAK4:IRAK1 e71:dsRNA:TLR7:MYD88:IRAK4:IRAK1:TRAF6 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p7 p8 p9
Model Detail
904.0, 1424.0
24.0, 24.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p7 p8 p41

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
1038.0, 1206.0
28.0, 28.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
624.0, 1408.0
24.0, 24.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13 p14

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
1118.0, 654.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
475.0, 435.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p53 p59

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1290.0, 954.0
28.0, 28.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p47

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
806.0, 818.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p1 p2 p9 p20

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
533.0, 797.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12 p54 p55

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1304.0, 384.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p56

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
745.0, 869.5
29.5, 29.5

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p11 p34

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
187.0, 1123.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
875.0, 335.0
25.0, 25.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p33 p45

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1243.0, 875.0
26.0, 26.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p23

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
950.0, 1166.0
28.0, 28.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
999.0, 719.0
26.0, 26.0

TBK1{active}

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p46

p1 p12

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
325.0, 593.0
30.0, 30.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
436.0, 684.0
32.0, 32.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p25

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
787.0, 1210.5
26.5, 26.5

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
821.0, 593.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p27 p28 p42 p48 p49

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1313.0, 605.0
22.0, 22.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p57

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
451.0, 731.0
25.0, 25.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
326.0, 770.0
28.0, 28.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p44 p45

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
318.0, 670.0
28.0, 28.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1049.0, 873.0
30.0, 30.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1 p2

p3 p23 p26

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
593.0, 1001.0
30.0, 30.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12

p17 p18 p19 p40

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1273.0, 445.0
22.0, 22.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1219.0, 403.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
435.0, 1347.0
26.0, 26.0

ATF-2:c-Jun

--

MO000055971

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m31298

10

false

infinite

0

unit false false false
TRANSPATHMO000055971

--

Go back
842.0, 482.0
28.0, 28.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p31

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
1148.0, 696.0
24.0, 24.0

ISG15

--

MO000069094

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m43938

10

false

infinite

0

unit false false false
TRANSPATHMO000069094

--

Go back
939.0, 395.0
26.0, 26.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
787.0, 427.0
34.0, 34.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
297.5102580135421, 221.8365226916883
1132.4802553459476, 1644.3613307623145

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
361.4216264217912, 330.969824219975
1052.8794707416862, 1481.1053618723727

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
951.5, 1282.237658285924
24.913011561754452, 34.76234171407598

(IRF-3{p})2:CBP

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p7 p15 p16

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
811.5, 1267.9825656083685
17.929161314002567, 25.01743439163149

(IRF-3{p})2:p300

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p8

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
732.0, 1236.0
24.0, 24.0

IRF-3

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p10 p40

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
220.0, 1213.6753975678207
16.17399438727783, 37.32460243217961

IFN

--

e14

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
979.0, 1446.0380622837372
50.55363321799308, 26.961937716262977

IFN-alpha1

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p15

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
751.0, 1460.2456747404847
42.66435986159169, 22.75432525951557

IFN-alpah4

--

e16

cso30:c:mRNA

cso30:i:CC_NuclearChromosome

--

p17

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
810.0, 1486.2595155709344
35.13840830449827, 18.740484429065745

IFN-alpha7

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
682.0, 1514.6851211072665
39.96539792387543, 21.314878892733564

IFN-alpha14

--

e18

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
638.0, 717.1400000000001
28.48, 21.360000000000003

cullin1

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p22

p20

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
297.5102580135421, 221.8365226916883
1132.4802553459476, 1644.3613307623145

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
744.0, 570.4861878453039
24.76243093922652, 27.513812154696133

cullin1:IRF-3

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
561.0, 572.132596685083
21.480662983425418, 23.867403314917137

cullin1:IRF-3{ub}

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1126.0, 940.232044198895
28.59116022099447, 31.767955801104964

IRF-3{p}:pin1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1127.0, 1058.0441988950276
25.16022099447514, 27.955801104972373

Pin1:IRF-3{ub}n

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1244.0, 767.1436464088399
23.2707182320442, 25.85635359116023

IRF-3{p}:ISG15

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p24

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
972.5, 529.7647058823529
23.058823529411764, 28.235294117647058

ddx58:dsRNA

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p29

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
689.5, 483.9641726378936
20.44592567905349, 25.035827362106318

dsRNA:IFIH1

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p30

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
926.5, 478.49403560286305
19.712607817948246, 27.50596439713709

dsRNA:DDX58:MAVS

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p32

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
670.5, 374.6922371077262
19.570563406129562, 27.307762892273804

dsRNA:IFIH1:MAVS

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p33

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
869.0, 623.1675387401892
29.728315556449996, 18.33246125981083

LGP2

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
320.15986312046084, 244.4861277986073
1087.18104513211, 1599.0621205484765

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
982.5, 576.0139976670555
19.588568571904684, 23.986002332944512

DDX58:LGP2

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1056.0, 338.6470588235294
16.411764705882355, 27.352941176470594

dsRNA:DDX58:MAVS:TRAF3

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p34

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
546.0, 330.44117647058823
20.73529411764706, 34.558823529411775

dsRNA:IFIH1:MAVS:TRAF3

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1072.0, 604.1764705882355
23.29411764705882, 38.82352941176472

dsRNA:DDX58:MAVS:TRAF3:ikk-i

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35 p36 p37

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1198.0, 710.0
28.0, 28.0

JNK{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35

p38

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1262.0, 1098.0
28.0, 28.0

IKK{active}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p47

p39

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
955.0, 663.0
26.0, 26.0

TBK1

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p46

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
487.0, 1475.0
26.0, 26.0

ATF-2:c-Jun{active}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p40

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000055971

--

Go back
1229.0, 1171.7458563535913
21.828729281767956, 24.25414364640884

NF-kappaB

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1290.0, 1315.900552486188
28.889502762430936, 32.09944751381216

NF-kappaB{active}

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
362.0616325682613, 284.12293673571526
1003.3775062365097, 1519.7885026742595

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
626.0, 1571.2594654788418
52.11581291759465, 18.240534521158132

IFN-beta

--

e40

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p40

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
846.0, 1573.048470043713
51.00539984571869, 14.451529956286965

IFN-beta enhancesome complex

--

e41

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

p41

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
331.0, 878.3235294117646
26.205882352941178, 43.6764705882353

dsRNA:TLR3:TRIF:TRAF6

--

e42

cso30:c:Complex

cso30:i:CC_Extracellular

--

p44

p47

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
331.0, 945.5882352941177
26.64705882352941, 44.411764705882355

dsRNA:TLR3:TRIF:TRAF3

--

e43

cso30:c:Complex

cso30:i:CC_Extracellular

--

p45

p46

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1162.3444143136178, 409.3693891870368
127.02907098022088, 212.07395748392796

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
1162.3444143136178, 409.3693891870368
127.02907098022088, 212.07395748392796

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
1162.3444143136178, 409.3693891870368
127.02907098022088, 212.07395748392796

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
1249.5, 407.44332383249287
21.470949353212017, 41.556676167507135

dsRNA:TLR7

--

e47

cso30:c:Complex

cso30:i:CC_Extracellular

--

p48

p56

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1280.5, 485.47993860995393
14.735365051523784, 28.520061390046042

dsRNA:TLR9

--

e48

cso30:c:Complex

cso30:i:CC_Extracellular

--

p49

p50

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1273.5, 517.8003303358415
20.209763259313636, 28.199669664158556

dsRNA:TLR9:MYD88

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1054.5, 999.4155974004332
27.427262122979492, 33.58440259956673

(IRF-3{p})2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
531.2297154674992, 1085.9290377711814
640.9802691930895, 581.2986798827458

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
600.4603590674975, 1099.7049714090456
374.8003808689576, 563.3942030896427

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
539.585137970947, 1093.687644381526
624.269424186194, 565.7814666620562

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
540.7787697571539, 1094.8812761677311
621.8821606137795, 563.3942030896427

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
531.2297154674992, 1085.9290377711814
640.9802691930895, 581.2986798827458

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
531.2297154674992, 1085.9290377711814
640.9802691930895, 581.2986798827458

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
540.7787697571539, 1094.8812761677311
621.8821606137795, 563.3942030896427

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
999.1333756605926, 1324.6553950125547
40.04492535048389, 36.25119558043805

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
894.0937784743888, 1491.7638450815168
113.39501968965267, 102.65233361379094

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
531.2297154674992, 1085.9290377711814
640.9802691930895, 581.2986798827458

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
884.5, 1209.6447258790197
23.1568071988002, 28.35527412097984

(IRF-3{p})2

--

e6

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p4

p5 p6

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
682.3051583685802, 1344.25336780054
20.29890330377214, 9.773546035149556

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
681.6273205295647, 1315.106340722901
69.47837849902251, 125.06108129824051

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
710.7743476072039, 1396.4468814046838
10.845405424237653, 10.845405424237654

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1268.0, 555.1176470588235
15.529411764705884, 25.88235294117647

dsRNA:TLR9:MYD88:IRAK4

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p52

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1221.0, 624.9399999999998
30.079999999999995, 22.560000000000002

IRAK1

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p58

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1237.0, 577.0882352941177
22.147058823529417, 36.911764705882355

dsRNA:TLR9:MYD88:IRAK4:IRAK1

--

e65

cso30:c:Complex

cso30:i:CC_Extracellular

--

p52

p53

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1198.0, 598.5882352941176
20.647058823529417, 34.41176470588236

dsRNA:TLR9:MYD88:IRAK4:IRAK1:TRAF6

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
421.0, 1105.0
30.0, 30.0

IRF-7{active}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p55

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1168.5, 408.0234905487247
22.91649844008075, 31.976509451275472

dsRNA:TLR7:MYD88

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1158.0, 447.2058823529411
19.676470588235293, 32.79411764705882

dsRNA:TLR7:MYD88:IRAK4

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
322.38939675206353, 226.45356267870392
1110.610307776349, 1573.7061187679617

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1158.0, 579.3529411764706
19.588235294117645, 32.64705882352941

dsRNA:TLR7:MYD88:IRAK4:IRAK1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p59

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1163.0, 490.32352941176487
26.205882352941174, 43.6764705882353

dsRNA:TLR7:MYD88:IRAK4:IRAK1:TRAF6

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p55

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
326.35716708233605, 254.2279549906105
1065.4217020272495, 1546.992311343565

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
336.9378879630627, 282.00234730251736
1060.557467537048, 1526.7038948214927

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1005.0, 821.0
21.0, 21.0

p1

p1

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000019331 MO000022224

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c5 : 1
stoichiometry:c7 : 1
stoichiometry:c2 : 1

m977*m3902*m119368*0.1

nodelay

--

true

0

false

PMID: 17395583, 9463386, 12692549, 9566918, 12702806 Transcriptional activity of IRF-3 is controlled by virus and dsRNA-induced, C-terminal phosphorylation events on serines 385 and 386, as well as the serine/threonine cluster between amino acids 396 and 405, mediated by the IKK-related kinases TBK-1 and IKK{epsilon}

Go back
694.0, 1074.0
19.0, 19.0

p10

p10

cso30:i:ME_NuclearExport

cso30:i:CC_Cytosol

--

e13

MO000007694

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 17395583, 10805757 Inactive IRF-3 constitutively shuttles into and out of the nucleus

Go back
551.0, 863.0
17.0, 17.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000016608

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m980*m1599*0.1

nodelay

--

true

0

false

PMID: 17395583, 12692549, 12702806 An important breakthrough in the understanding of innate immune response signaling was the demonstration that IRF-3 and IRF-7 are the primary in vivo targets of the IKK-related kinases, TBK-1/NAK/T2K and IKK{epsilon}/IKKi. PMID: 17395583, 15367631, 14679297 Both kinases directly phosphorylate IRF-3 and IRF-7 in their C-terminal signal-responsive domain

Go back
584.0, 844.0
15.0, 15.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000019331

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c32 : 1
stoichiometry:c31 : 1

m980*m3902*0.1

nodelay

--

true

0

false

PMID: 17395583, 12692549, 12702806 An important breakthrough in the understanding of innate immune response signaling was the demonstration that IRF-3 and IRF-7 are the primary in vivo targets of the IKK-related kinases, TBK-1/NAK/T2K and IKK{epsilon}/IKKi. PMID: 17395583, 15367631, 14679297 Both kinases directly phosphorylate IRF-3 and IRF-7 in their C-terminal signal-responsive domain

Go back
613.0, 1333.0
21.0, 21.0

p13

p13

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e14

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c33 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 17395583, 10924517 IFN and lipopolysaccharide treatment modulates transcription of the IRF-7 gene.

Go back
594.0, 1366.0
19.0, 19.0

p14

p14

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

MO000016882

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c34 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17395583, 10924517 IFN and lipopolysaccharide treatment modulates transcription of the IRF-7 gene.

Go back
995.0, 1359.0
17.0, 17.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

Go back
1042.0, 1294.0
19.0, 19.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

G010522

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

Go back
761.0, 1401.0
21.0, 21.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

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816.0, 1404.0
23.0, 23.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

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695.0, 1415.0
17.0, 17.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

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949.0, 877.0
21.0, 21.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000016608 MO000022224

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c6 : 1
stoichiometry:c8 : 1
stoichiometry:c4 : 1

m977*m1599*m119368*0.1

nodelay

--

true

0

false

PMID: 17395583, 9463386, 12692549, 9566918, 12702806 Transcriptional activity of IRF-3 is controlled by virus and dsRNA-induced, C-terminal phosphorylation events on serines 385 and 386, as well as the serine/threonine cluster between amino acids 396 and 405, mediated by the IKK-related kinases TBK-1 and IKK{epsilon}

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746.0, 718.5
19.5, 19.5

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007694 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m977*m19*0.1

nodelay

--

true

0

false

PMID: 17395583, 17015689 IRF-3 is recruited to Cullin1 following virus infection, and expression of a dominant-negative Cullin1 inhibits IRF-3 degradation.

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672.0, 572.0
23.0, 23.0

p21

p21

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17395583, 17015689, 9566918 IRF-3 is targeted for proteasomal degradation (9) following virus infection, and polyubiquitination is required for IRF-3 degradation.

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516.0, 620.0
23.0, 23.0

p22

p22

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e21

e19 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m21*0.1

nodelay

--

true

0

false

Go back
1129.0, 876.5
22.5, 22.5

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041456 MO000017197

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m19324*m2065*0.1

nodelay

--

true

0

false

PMID: 17395583 After stimulation by dsRNA, phosphorylation of the Ser339?Pro340 motif of IRF-3 results in the interaction with Pin1, polyubiquitination, and then proteasome-dependent degradation of IRF-3

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1131.0, 1007.0
17.0, 17.0

p24

p24

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e22 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c66 : 1
stoichiometry:c59 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 17395583 After stimulation by dsRNA, phosphorylation of the Ser339?Pro340 motif of IRF-3 results in the interaction with Pin1, polyubiquitination, and then proteasome-dependent degradation of IRF-3 PMID: 17395583 ISGylation subverts ubiquitin-mediated degradation of IRF-3 and enhances IRF-3-dependent gene activity

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1027.0, 1067.0
17.0, 17.0

p25

p25

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e23

MO000019479 MO000017197

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 17395583 After stimulation by dsRNA, phosphorylation of the Ser339?Pro340 motif of IRF-3 results in the interaction with Pin1, polyubiquitination, and then proteasome-dependent degradation of IRF-3

Go back
1114.0, 770.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000069094 MO000041456

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m43938*m19324*0.1

nodelay

--

true

0

false

PMID: 17395583 IRF-3 can also be stabilized in infected cells; both IFN treatment and RNA virus infection increase conjugation of the IFN-induced, ubiquitin-like protein ISG15 to IRF-3.

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847.0, 531.0
17.0, 17.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000066987

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 17395583, 15208624, 15563593 Antiviral immune responses can be triggered by dsRNA and the 5'-triphosphate RNA structure of viral nucleic acids.These structures are "sensed" by the cytoplasmic RNA helicase proteins RIG-I and MDA5

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794.0, 510.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000103999

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 17395583, 15208624, 15563593 Antiviral immune responses can be triggered by dsRNA and the 5'-triphosphate RNA structure of viral nucleic acids.These structures are "sensed" by the cytoplasmic RNA helicase proteins RIG-I and MDA5

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991.0, 478.5
18.5, 18.5

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000094908

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m25*m68199*0.1

nodelay

--

true

0

false

PMID: 17395583, 16177806, 16153868, 16125763, 16127453, 15563593 The protein responsible for downstream signaling is a mitochondrial adapter, known as MAVS/IPS-1/ VISA/Cardif that interacts with RIG-I via CARD domain interactions.

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1054.0, 934.0
19.0, 19.0

p3

p3

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17395583, 10082512 Based on available biochemical data, a model for IRF-3 activation proposes that C-terminal phosphorylation induces a conformational change in IRF-3 that allows homo- and heterodimerization, nuclear localization, and association with the co-activator CBP/p300.

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753.0, 397.0
21.0, 21.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000094908

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m26*m68199*0.1

nodelay

--

true

0

false

PMID: 17395583, 16177806, 16153868, 16125763, 16127453, 15563593 The protein responsible for downstream signaling is a mitochondrial adapter, known as MAVS/IPS-1/ VISA/Cardif that interacts with RIG-I via CARD domain interactions.

Go back
873.0, 577.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m41844*m29*0.1

nodelay

--

true

0

false

PMID: 17395583, 17190814 LGP2 was shown to interact directly with RIG-I to block RIG-I dimerization and downstream signaling to the IFN response.

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990.0, 342.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e27

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m1872*m27*0.1

nodelay

--

true

0

false

PMID: 17395583 MAVS links RIG-I and MDA5 to TRAF3.

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720.0, 336.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000016963

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m28*m1872*0.1

nodelay

--

true

0

false

PMID: 17395583 MAVS links RIG-I and MDA5 to TRAF3.

Go back
802.0, 714.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m1599*m31*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
1306.0, 710.0
19.0, 19.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
1267.0, 1034.5
18.5, 18.5

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c96 : 1
stoichiometry:c95 : 1

m207*m33*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
1035.0, 667.0
17.0, 17.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e33

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c98 : 1

m37*m33*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
490.0, 1410.0
19.0, 19.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000055971 e34

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m31298*m35*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
1295.0, 1255.0
17.0, 17.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e35

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m39*m36*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
886.0, 1022.0
19.0, 19.0

p4

p4

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 17395583, 10082512 Based on available biochemical data, a model for IRF-3 activation proposes that C-terminal phosphorylation induces a conformational change in IRF-3 that allows homo- and heterodimerization, nuclear localization, and association with the co-activator CBP/p300.

Go back
759.0, 1571.0
17.0, 17.0

p40

p40

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e40 e39 e37 e13 MO000041457

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c107 : 1

m41*m40*m38*m13*m19325*0.1

nodelay

--

true

0

false

PMID: 17395583 TRAF-dependent induction of the kinases JNK, IKK{alpha}, IKKbeta, IKK{epsilon}, TBK-1, and IRAK1 induce the binding of ATF2-c-Jun, NF-{kappa}B (p50-p65 complex), IRF-3, and IRF-7 to sequence-specific PRDs located in the IFN-beta enhancer.

Go back
935.0, 1518.5
18.5, 18.5

p41

p41

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e41

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17395583 Coordinated assembly of these factors forms the IFN-beta enhanceosome, which is responsible for the transcriptional induction of this antiviral cytokine.

Go back
411.0, 599.0
17.0, 17.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
399.0, 735.0
17.0, 17.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
245.0, 825.0
21.0, 21.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000000212

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m19305*m183*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
244.0, 904.0
23.0, 23.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041437 MO000016963

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m19305*m1872*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
1066.0, 722.0
19.0, 19.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 e43

MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m37*m44*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
1211.0, 1027.0
17.0, 17.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e42

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m207*m43*0.1

nodelay

--

true

0

false

PMID: 17395583 Viral pathogen-associated molecular patterns trigger multiple signaling cascades through Toll-like receptor-dependent (TLR-3, TLR-7, and TLR-9) and -independent (RIG-I and MDA5) pathways leading to kinase activation through TRAF family members.

Go back
1257.0, 341.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 MO000022224

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m19940*m119368*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1243.0, 475.0
17.0, 17.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 MO000022224

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m19828*m119368*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
954.0, 1214.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e6 MO000017462

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m6*m2282*0.1

nodelay

--

true

0

false

PMID: 17395583, 10082512 Based on available biochemical data, a model for IRF-3 activation proposes that C-terminal phosphorylation induces a conformational change in IRF-3 that allows homo- and heterodimerization, nuclear localization, and association with the co-activator CBP/p300.

Go back
1452.0, 492.5
15.5, 15.5

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m1572*m49*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1316.0, 564.0
15.0, 15.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000039077

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m63*m17258*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1285.0, 657.0
21.0, 21.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e63 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m64*m65*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
990.0, 178.0
19.0, 19.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000000212

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m66*m183*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
425.0, 989.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m980*m67*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
483.0, 1039.0
17.0, 17.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e71

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c166 : 1
stoichiometry:c154 : 1

m980*m72*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1126.0, 322.0
19.0, 19.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 MO000016573

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m48*m1572*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1060.0, 408.0
15.0, 15.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000039077

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m69*m17258*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
1061.0, 473.0
21.0, 21.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e64

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m70*m65*0.1

nodelay

--

true

0

false

PMID: 17395583 In plasmacytoid dendritic cells, TLR-7 or TLR-9 engagement leads to direct activation of IRF-7 through MyD88/TRAF6/IRAK4/IRAK1 recruitment.

Go back
798.0, 362.0
19.0, 19.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c167 : 1

m183*m71*0.1

nodelay

--

true

0

false

--

Go back
847.0, 1215.0
17.0, 17.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000019984

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6*m4512*0.1

nodelay

--

true

0

false

PMID: 17395583, 10082512 Based on available biochemical data, a model for IRF-3 activation proposes that C-terminal phosphorylation induces a conformational change in IRF-3 that allows homo- and heterodimerization, nuclear localization, and association with the co-activator CBP/p300.

Go back
905.0, 1333.5
21.5, 21.5

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17395583, 10805757 phosphorylation-dependent association with CBP/p300 retains IRF-3 in the nucleus and induces transcription of IFN-beta and other genes. PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only. PMID: 17395583 IRF-3 possesses a restricted DNA binding site specificity and interacts with CBP.

Go back
842.0, 1334.0
19.0, 19.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 17395583, 10805757 phosphorylation-dependent association with CBP/p300 retains IRF-3 in the nucleus and induces transcription of IFN-beta and other genes. PMID: 17395583, 10938111 Human IFN-beta, IFN-{alpha}1, and RANTES (regulated on activation normal T cell expressed and secreted) promoters are stimulated by IRF-3 coexpression, whereas IFN-{alpha}4, -{alpha}7, and -{alpha}14 promoters are preferentially induced by IRF-7 only.

Go back
810.0, 966.0
19.0, 19.0

p9

p9

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000007694

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m977*0.1

nodelay

--

true

0

false

PMID: 17395583, 10805757 Inactive IRF-3 constitutively shuttles into and out of the nucleus

Go back
834.0, 832.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 953.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
459.0, 1373.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 1429.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.7229128767959, 738.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1250.0, 1196.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1304.0, 1272.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1279.0, 1126.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 1580.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 1580.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.2595358144902, 1338.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 1492.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.9653815658512, 1017.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 1260.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 1031.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.0, 1539.6615021863595

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.2690275348773, 1455.67147404649

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 608.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 608.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.06086952369344, 616.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.0, 695.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.85994340570034, 749.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 744.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 1041.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.8093669577919, 793.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.09651633853315, 461.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 843.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.27434391436293, 798.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.9521910482008, 360.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 922.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.0, 683.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 732.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.0, 737.4619897851987

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1234.2273043158027, 979.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 1224.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1226.0, 1044.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 902.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1239.0, 368.9771443289089

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 363.0709773902161

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.8834522085988, 362.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1266.1070902829529, 466.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 489.28801621390073

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1260.0, 488.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1328.0, 405.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1295.0, 500.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.0, 1233.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1301.8685578522307, 501.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1294.0, 542.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1291.984420627863, 569.4990262892414

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1324.0, 587.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1279.0, 581.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1251.0, 644.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.506694597132, 619.6098187424603

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1016.9999592173666, 188.02554448023616

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
501.0, 196.6185045325348

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 197.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.0, 1194.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.07841912241383, 827.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 1010.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.1630215331574, 621.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.8364087048146, 827.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.90258815435106, 1056.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1151.3342580445078, 343.88642763433455

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.530715233249, 337.69969036663645

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 341.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.9779098504835, 416.59409966971685

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.3033918483932, 425.9261801840383

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 1224.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 419.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1089.828398279894, 466.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.8594077652413, 498.44677341557644

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 494.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 375.8600469883655

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.7940411533235, 382.2238613621835

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.29482733884726, 522.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.0, 375.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.0, 1224.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.3071142168176, 1232.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.8874480940947, 1312.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.0, 842.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 1355.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 1293.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 1353.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 846.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.1490669328924, 985.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.9019035839862, 1100.7706346431435

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 853.2664709296508

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 827.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 880.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.9845956619939, 872.4962178095025

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.0, 838.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 826.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.0, 859.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.6936415336965, 736.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
626.0, 1354.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 1385.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
213.0, 1144.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
236.0, 1234.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1004.0, 1376.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
974.0, 1317.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1052.0, 1242.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
970.0, 888.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 1300.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.0, 1422.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 1031.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.0, 1427.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 1031.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
702.1927151438009, 1432.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 1031.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.178496632733, 744.8220353187476

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 728.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 606.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.0, 745.0

c5

c5

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 584.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 584.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.4057970281387, 596.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 640.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.9586826857845, 643.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.0, 888.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0, 888.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 899.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1140.0, 972.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 1024.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 884.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1051.9947793925485, 1073.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.72590718468217, 714.3315323550726

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1044.0, 904.1962549665959

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1132.5777087639997, 720.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 795.9814649373426

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 780.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1145.7754422713235, 793.0

c66

c66

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
840.0, 555.6388542106463

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 510.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 540.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 623.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.7055898093053, 536.5285977302406

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 461.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.7824497174829, 499.85296421844834

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 504.71811056990185

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 421.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.9921104517297, 489.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
709.0, 424.46988867442553

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 408.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.7824497174829, 391.85296421844834

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 510.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 623.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
884.0, 606.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 588.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 348.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 368.2636750760036

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 352.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.0, 361.86745234925706

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 348.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 348.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.0, 740.6168067448987

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.4855296281586, 364.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 903.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 630.7794882227096

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0, 672.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.9943809256733, 720.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1095.0, 629.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1282.6996903666366, 982.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1276.0, 1053.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1093.0, 643.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.0, 676.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.9691115068547, 684.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1055.9115249081194, 640.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back