1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17513437.csml convertedTime:2009.07.01.11:04

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Regulation of nitric oxide synthesis and apoptosis by arginase and argininerecycling.
Authors Mori M.
Affiliation Laboratory of Molecular Genetics, Faculty of Pharmaceutical Sciences, SojoUniversity, Kumamoto 860-0082, Japan. mori-m@ph.sojo-u.ac.jp
Abstract Nitric oxide (NO) is synthesized from arginine and O2 by NO synthase (NOS).Citrulline formed as a by-product of the NOS reaction can be recycled toarginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL).We found that AS and sometimes AL are coinduced with inducible NOS (iNOS) invarious cells. In these cells, NO was synthesized from citrulline (via arginine)as well as from arginine, indicating operation of the citrulline-NO cycle. Onthe other hand, we found that arginase isoforms (types I and II) are coinducedwith iNOS by LPS in rodent tissues and cultured macrophages. Km values forarginine of arginase I and II (approximately 10 mmol/L) are much higher thanthat of iNOS (approximately 5 micromol/L), whereas Vmax of arginase I and IIwere 10(3)-10(4) times higher than that of iNOS in activated macrophages. Thus,Vmax/Km values of arginases were close to that of iNOS, and these enzymes wereexpected to compete for arginine in the cells. In fact, NO production by iNOS inactivated macrophages was decreased by coinduction of arginase I or arginase II.Low concentrations of NO protect cells from apoptosis, whereas excessive NOcauses apoptosis. We found that NO causes endoplasmic reticulum (ER) stress,induces a transcription factor, CAAT/enhancer binding protein (C/EBP) homologousprotein (CHOP), and leads to apoptosis. These results suggest that the argininemetabolic enzymes and the ER stress-CHOP pathway can be good targets to regulateNO production and NO-mediated apoptosis in diseases associated withoverproduction or impaired production of NO.
PMID 17513437
Model Abstract

Entity

G010217:GRP78 G010432:p53 G010514:iNOS MO000000289:TNF-alpha MO000006117:GRP78 MO000007321:IL-13 MO000016665:IFNgamma MO000017053:IL-4 MO000017059:IL-4R MO000021201:iNOS MO000021614:Hsp70 MO000021732:glucocorticoids MO000034204:IL-13R MO000042409:LPS MO000068737:argininosuccinate lyase MO000089591:argininosuccinate synthase MO000089992:arginase MO000100299:p53 e1: e10:TNF-alphaR e11:Urea e12:ornithine e13:NH3 e14:CO2 e15:Ornithine e16:carbamylphosphate cynthase I e17:ornithine transcarbamylase e18:LPS receptor e19:LPS:Receptor e2: e20:Argininosuccinate synthase e21:Argininisuccinate lyase e22:NO e23:Glucocorticoid Receptor e24:Glucocorticoids:Receptor e25:arginase I e26:Arginase I e27:IL-4:IL-4R e28:IL-13:IL-13R e29:arginase II e3: e30:arginase II e31:Ligand:LXRs e32:Arginase I e33:IFNgammaR e34:IFNgamma:IFNgammaR e35:dexamethasone e36:Dibutyryl CAMP e37:Hsp70 e38:TNF_alpha:TNF-alphaR e39:SNAP e4: e40:DjA1 e41:DjA1 e42:DjB1 e43:DjB1 e44:CHOP e45:CHOP e5:citrulline e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Arginine e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p5 p6 p7 p8 p9
Model Detail
412.0, 996.0
24.0, 24.0

GRP78

--

G010217

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p35 p36

true true true true

csml-variable:Double

m93206

10

false

infinite

0

unit false false false
TRANSFACG010217

--

Go back
226.0, 906.0
28.0, 28.0

p53

--

G010432

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p38

true true true true

csml-variable:Double

m93404

10

false

infinite

0

unit false false false
TRANSFACG010432

--

Go back
562.0, 802.0
27.0, 27.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p3 p21 p22 p23

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
770.0, 50.0
20.0, 20.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
761.0, 1165.0
22.0, 22.0

GRP78

--

MO000006117

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p36

--

true true true true

csml-variable:Double

m746

10

false

infinite

0

unit false false false
InterProIPR000886
TRANSPATHMO000006117

--

Go back
1046.0, 1066.0
20.0, 20.0

IL-13

--

MO000007321

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m836

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000007321

--

Go back
1049.0, 189.0
21.0, 21.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1043.0, 919.0
18.0, 18.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
966.0, 926.0
20.0, 20.0

IL-4R

--

MO000017059

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1952

10

false

infinite

0

unit false false false
TRANSPATHMO000017059

--

Go back
710.0, 578.0
27.0, 27.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
826.0, 366.0
19.0, 19.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
1050.0, 746.0
20.0, 20.0

glucocorticoids

--

MO000021732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6069

10

false

infinite

0

unit false false false
TRANSPATHMO000021732

--

Go back
963.0, 1079.0
26.0, 26.0

IL-13R

--

MO000034204

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m12757

10

false

infinite

0

unit false false false
TRANSPATHMO000034204

--

Go back
1113.0, 561.0
22.0, 22.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
569.0, 285.0
22.0, 22.0

argininosuccinate lyase

--

MO000068737

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p1

true true true true

csml-variable:Double

m43582

10

false

infinite

0

unit false false false
TRANSPATHMO000068737

--

Go back
471.0, 487.0
18.0, 18.0

argininosuccinate synthase

--

MO000089591

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p1

true true true true

csml-variable:Double

m63193

10

false

infinite

0

unit false false false
TRANSPATHMO000089591

--

Go back
511.0, 431.0
26.0, 26.0

arginase

--

MO000089992

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p2

true true true true

csml-variable:Double

m63554

10

false

infinite

0

unit false false false
TRANSPATHMO000089992

--

Go back
163.0, 587.0
26.0, 26.0

p53

--

MO000100299

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m73311

10

false

infinite

0

unit false false false
TRANSPATHMO000100299

--

Go back
76.75, 84.99690800911759
935.1474678678445, 1357.83412334411

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
837.5, 104.0
20.676625659050966, 31.81019332161687

TNF-alphaR

--

e10

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p27

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
627.0, 532.0
42.59041211101765, 24.134566862910003

Urea

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
714.0, 488.0
43.52396972245583, 24.663582842724978

ornithine

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
210.0, 287.0
42.31286795626577, 23.977291841883936

NH3

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
240.0, 220.0
40.723296888141306, 23.07653490328007

CO2

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
303.0, 196.0
42.287636669470146, 23.962994112699747

Ornithine

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
329.0, 391.5
21.60000000000001, 16.200000000000003

carbamylphosphate cynthase I

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
494.0, 227.0
11.4798877455566, 26.492048643592135

ornithine transcarbamylase

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
962.5, 599.0
27.713532513181022, 42.636203866432325

LPS receptor

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
969.5, 679.0
21.695242271431702, 41.99079149309362

LPS:Receptor

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
76.75, 84.99690800911759
935.1474678678445, 1357.83412334411

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
379.0, 777.0
42.352941176470594, 22.588235294117652

Argininosuccinate synthase

--

e20

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
447.0, 849.0
42.352941176470594, 22.58823529411765

Argininisuccinate lyase

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
792.4339781328848, 242.64592094196803
31.387720773759455, 17.786375105130357

NO

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
964.5, 786.0
23.898066783831283, 36.76625659050968

Glucocorticoid Receptor

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
964.5, 847.0
22.05547029160272, 42.688007016005265

Glucocorticoids:Receptor

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
366.0, 877.5
60.0, 13.0

arginase I

--

e25

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p12

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
531.0, 1001.0
41.10726643598616, 21.92387543252595

Arginase I

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
966.5, 989.0
19.696996272747203, 38.12321859241395

IL-4:IL-4R

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
965.5, 1139.0
21.382591536943654, 41.385661039245775

IL-13:IL-13R

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
349.0, 932.0
45.98615916955018, 24.525951557093425

arginase II

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p16 p18 p24 p25

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
95.4529493573569, 103.6998573664745
897.7415691531311, 1320.4282246293958

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
317.5, 581.0
13.723284363050919, 22.253974642785273

arginase II

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
965.5, 1215.0
21.287436965577722, 41.201490901118184

Ligand:LXRs

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
831.0, 1034.5
25.91999999999999, 19.439999999999998

Arginase I

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
963.5, 228.0
25.6115992970123, 39.402460456942

IFNgammaR

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
966.5, 297.0
19.61543521157642, 37.96535847401887

IFNgamma:IFNgammaR

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1029.0, 417.0
38.95710681244744, 22.075693860386878

dexamethasone

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p22 p24

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1038.5, 494.0
18.755684225391892, 19.073577178364637

Dibutyryl CAMP

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p23 p25

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
527.0, 849.0
42.6643598615917, 22.75432525951557

Hsp70

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
697.5, 99.0
21.803990352992763, 42.201271650953736

TNF_alpha:TNF-alphaR

--

e38

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
326.0, 42.0
35.172413793103445, 19.931034482758623

SNAP

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p29 p34 p36

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
130.05340566846724, 136.4300187418489
828.5406565309108, 1254.9679018786467

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
427.0, 745.0
41.26297577854672, 22.00692041522491

DjA1

--

e40

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

--

p30

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
202.0, 455.5
27.100175746924428, 17.615114235500876

DjA1

--

e41

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
523.0, 749.0
41.26297577854672, 22.00692041522491

DjB1

--

e42

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

--

p31

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
280.0, 447.0
15.006548175865298, 34.63049579045837

DjB1

--

e43

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
606.0, 874.0
36.17647058823529, 19.294117647058826

CHOP

--

e44

cso30:c:mRNA

cso30:i:CC_Extracellular

--

--

p33 p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
800.5, 856.0
14.497685651036427, 23.509760515194206

CHOP

--

e45

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
425.0, 323.0
22.03278688524591, 18.360655737704917

citrulline

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
187.71822969985044, 692.0
511.94623985325455, 464.2789921946653

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
243.01223698381457, 703.0027371595243
299.35031529594414, 449.97881789708833

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
194.39164437205307, 698.1967421956166
498.59941050884964, 451.8855078034317

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
195.34498932522476, 699.1500871487883
496.6927206025058, 449.97881789708833

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
187.71822969985044, 692.0
511.94623985325455, 464.2789921946653

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
187.71822969985044, 692.0
511.94623985325455, 464.2789921946653

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
195.34498932522476, 699.1500871487883
496.6927206025058, 449.97881789708833

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
561.4294513431944, 882.6689906343594
31.98358817533087, 28.953564032404838

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
477.53509546407645, 1016.1372840784111
90.56777055132063, 81.9876659727746

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
187.71822969985044, 692.0
511.94623985325455, 464.2789921946653

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
589.0, 385.0
37.720773759461736, 21.375105130361653

Arginine

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
308.38107791004177, 898.3217477624142
16.212585190169833, 7.806059536007708

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
307.8396937994968, 875.0422310089851
55.49187133084887, 99.885368395528

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
331.1192105529266, 940.0083242743694
8.662145768717863, 8.662145768717872

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
89.0, 87.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
92.0, 108.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
76.7676592146696, 137.77752397362428
870.1115166883168, 1252.5513063823541

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
426.0, 382.0
19.0, 19.0

p1

p1

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c1 : 1

m5*m43582*m63193*0.1

nodelay

--

true

0

false

PMID: 17513437 Arginine is synthesized from citrulline by successive actions of argininosuccinate synthetase (AS) and argininosuccinate lyase (AL), the third and fourth enzymes of the urea cycle (ornithine cycle).

Go back
585.0, 209.0
21.0, 21.0

p10

p10

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c64 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c57 : 1

m5*m5576*0.1

nodelay

--

true

0

false

PMID: 17513437,10592289 NO was produced from citrulline (via arginine) as well as from arginine in activated C6 cells and retinal pigment epithelial cells, indicating that the citrulline-NO cycle is actually functioning in these cells PMID: 17513437 When RAW264.7 cells are exposed to LPS and IFN-g, iNOS is induced, and NO production increases. PMID: 17513437, 9971738 When dexamethasone and dibutyryl cAMP are added, both iNOS and arginase II are induced, and NO production is much decreased PMID: 17513437 Thus, both cytosolic arginase I and mitochondrial arginase II are effective in down-regulating NO production and in preventing NO-mediated apoptosis in activated macrophages

Go back
1051.0, 807.0
17.0, 17.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m6069*m23*0.1

nodelay

--

true

0

false

PMID: 17513437 Transcription of the rat arginase I gene is induced by glucocorticoids in a delayed secondary manner.

Go back
422.0, 942.0
19.0, 19.0

p12

p12

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m24*m25*0.1

nodelay

--

true

0

false

PMID: 17513437 Transcription of the rat arginase I gene is induced by glucocorticoids in a delayed secondary manner.

Go back
1042.0, 966.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m1947*m1952*0.1

nodelay

--

true

0

false

Go back
614.0, 954.0
19.0, 19.0

p17

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17523437 Arginase I expression is induced in macrophages by Th2 cytokines such as IL-4 and IL-13.

Go back
1046.0, 1126.0
19.0, 19.0

p13

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m836*m12757*0.1

nodelay

--

true

0

false

Go back
327.0, 1207.0
17.0, 17.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c50 : 1
stoichiometry:c47 : 1

m29*m31*0.1

nodelay

--

true

0

false

PMID: 17513437,16943198 Marathe et al. found that arginase II is induced in macrophages by the liver X receptors (LXRs) that have been implicated in lipid metabolism and inflammation

Go back
466.0, 1058.0
19.0, 19.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17523437 Arginase I expression is induced in macrophages by Th2 cytokines such as IL-4 and IL-13.

Go back
262.0, 1162.0
19.0, 19.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c52 : 1

m29*m19*0.1

nodelay

--

true

0

false

PMID: 17513437,8898077,1731766,7507106 iNOS and arginase II are coinduced in LPS-stimulated RAW 264.7 macrophages

Go back
758.0, 1062.0
19.0, 19.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c55 : 1

m26*m19*0.1

nodelay

--

true

0

false

PMID: 17513437,9013624 Surprisingly, however, we found that arginase I, not arginase II, is coinduced with iNOS in rat peritoneal macrophages and in vivo in rat lung after LPS treatment

Go back
769.0, 425.0
21.0, 21.0

p6

p2

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c7 : 1
stoichiometry:c6 : 1

m6*m63554*0.1

nodelay

--

true

0

false

PMID: 17513437 The major site of arginine metabolism in ureotelic animals is the liver, where arginine generated in the urea cycle is rapidly converted to urea and ornithine by arginase with no net synthesis of arginine PMID: 17513437 In contrast, arginine is hydrolyzed to urea and ornithine by arginase.

Go back
1049.0, 257.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m1639*m33*0.1

nodelay

--

true

0

false

PMID: 17513437 When RAW264.7 cells are exposed to LPS and IFN-g, iNOS is induced, and NO production increases.

Go back
578.0, 618.0
19.0, 19.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m93479*m34*0.1

nodelay

--

true

0

false

PMID: 17513437 When RAW264.7 cells are exposed to LPS and IFN-g, iNOS is induced, and NO production increases.

Go back
650.0, 738.0
19.0, 19.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m93479*m35*0.1

nodelay

--

true

0

false

PMID: 17513437, 9971738 When dexamethasone and dibutyryl cAMP are added, both iNOS and arginase II are induced, and NO production is much decreased

Go back
802.0, 734.0
19.0, 19.0

p22

p23

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c68 : 1

m93479*m36*0.1

nodelay

--

true

0

false

PMID: 17513437, 9971738 When dexamethasone and dibutyryl cAMP are added, both iNOS and arginase II are induced, and NO production is much decreased

Go back
166.0, 750.0
19.0, 19.0

p22

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m29*m35*0.1

nodelay

--

true

0

false

PMID: 17513437, 9971738 When dexamethasone and dibutyryl cAMP are added, both iNOS and arginase II are induced, and NO production is much decreased

Go back
214.0, 634.0
19.0, 19.0

p22

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m29*m36*0.1

nodelay

--

true

0

false

PMID: 17513437, 9971738 When dexamethasone and dibutyryl cAMP are added, both iNOS and arginase II are induced, and NO production is much decreased

Go back
662.0, 790.0
19.0, 19.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c81 : 1
stoichiometry:c80 : 1

m37*m22*0.1

nodelay

--

true

0

false

PMID: 17513437,8995451 NO was reported to protect cultured hepatocytes from tumor necrosis factor-a-induced apoptosis by inducing heat shock protein 70 (Hsp70) PMID: 17513437 Among DnaJ homologs, which act as cochaperones of Hsp70, DjB1 was strongly induced, and DjA1 was weakly induced;

Go back
642.0, 42.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m230*m10*0.1

nodelay

--

true

0

false

PMID: 17513437,8995451 NO was reported to protect cultured hepatocytes from tumor necrosis factor-a-induced apoptosis by inducing heat shock protein 70 (Hsp70)

Go back
530.0, 38.0
19.0, 19.0

p28

p28

cso30:i:CE_ProgrammedCellDeath

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 17513437,8995451 NO was reported to protect cultured hepatocytes from tumor necrosis factor-a-induced apoptosis by inducing heat shock protein 70 (Hsp70)

Go back
409.0, 41.0
21.0, 21.0

p29

p29

cso30:i:CE_ProgrammedCellDeath

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c91 : 1
stoichiometry:c94 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 17513437 SNAP-induced apoptosis was prevented by coexpression of Hsp70 and DjB1 or DjA1.

Go back
605.0, 681.0
21.0, 21.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m19*m93479*0.1

nodelay

--

true

0

false

PMID: 17513437 When iNOS is induced in various cells stimulated by bacterial LPS and cytokines, AS and sometimes AL are coinduced. PMID: 17513437,8898077,1731766,7507106 iNOS and arginase II are coinduced in LPS-stimulated RAW 264.7 macrophages PMID: 17513437 When RAW264.7 cells are exposed to LPS and IFN-g, iNOS is induced, and NO production increases.

Go back
205.0, 529.0
21.0, 21.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 17513437 Among DnaJ homologs, which act as cochaperones of Hsp70, DjB1 was strongly induced, and DjA1 was weakly induced;

Go back
349.0, 453.0
21.0, 21.0

p30

p31

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17513437 Among DnaJ homologs, which act as cochaperones of Hsp70, DjB1 was strongly induced, and DjA1 was weakly induced;

Go back
878.0, 46.0
19.0, 19.0

p32

p32

cso30:i:CE_ProgrammedCellDeath

cso30:i:CC_Extracellular

--

e45

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17513437 Overexpression of CHOP in RAW264.7 cells resulted in apoptosis.

Go back
706.0, 890.0
19.0, 19.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c99 : 1
stoichiometry:c96 : 1

m44*m22*0.1

nodelay

--

true

0

false

PMID: 17513437,11591387 WhenRAW264.7 cellswere treated with LPS plus interferon-g or the NO donor SNAP, NO-mediated apoptosis occurred PMID: 17513437,11526215 We found that CHOP, a C/EBP family transcription factor that is involved in ER stress-induced apoptosis, is induced

Go back
534.0, 658.0
19.0, 19.0

p33

p34

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m39*m44*0.1

nodelay

--

true

0

false

PMID: 17513437,11591387 WhenRAW264.7 cellswere treated with LPS plus interferon-g or the NO donor SNAP, NO-mediated apoptosis occurred PMID: 17513437,11526215 We found that CHOP, a C/EBP family transcription factor that is involved in ER stress-induced apoptosis, is induced

Go back
626.0, 1114.0
19.0, 19.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c104 : 1

m93206*m19*m34*m22*0.1

nodelay

--

true

0

false

PMID: 17513437 BiP/GRP78, an ER chaperone that is known to be induced by ER stress, was also induced. PMID: 17513437 WhenRAW264.7 cellswere treated with LPS plus interferon-g or the NO donor SNAP, NO-mediated apoptosis occurred

Go back
566.0, 1174.0
19.0, 19.0

p35

p36

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m93206*m39*0.1

nodelay

--

true

0

false

PMID: 17513437 BiP/GRP78, an ER chaperone that is known to be induced by ER stress, was also induced. PMID: 17513437 WhenRAW264.7 cellswere treated with LPS plus interferon-g or the NO donor SNAP, NO-mediated apoptosis occurred

Go back
661.0, 289.0
19.0, 19.0

p37

p37

cso30:i:ME_DNADamage

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 17513437 High concentrations of NO induce apoptosis by the DNA damage-p53 pathway PMID: 17513437 It is generally thought that NO induces DNA damage, leading to cell death through induction of p53.

Go back
181.0, 673.0
21.0, 21.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1

m93404*0.1

nodelay

--

true

0

false

PMID: 17513437 High concentrations of NO induce apoptosis by the DNA damage-p53 pathway PMID: 17513437 It is generally thought that NO induces DNA damage, leading to cell death through induction of p53.

Go back
145.0, 49.0
21.0, 21.0

p39

p39

cso30:i:CE_ProgrammedCellDeath

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1

m73311*0.1

nodelay

--

true

0

false

PMID: 17513437 It is generally thought that NO induces DNA damage, leading to cell death through induction of p53.

Go back
314.0, 290.0
19.0, 19.0

p4

p4

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c14 : 1

m13*m14*m15*m16*m17*0.1

nodelay

--

true

0

false

PMID: 17513437 In adult animals, citrulline is produced primarily by the small intestine from NH3, CO2, and ornithine by carbamylphosphate synthetase I and ornithine transcarbamylase, the first 2 enzymes of the urea cycle, and is supplied to the kidney and probably to other tissues for synthesis of arginine.

Go back
697.0, 321.0
21.0, 21.0

p5

p5

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e6

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17513437 Citrulline is also formed from arginine as a coproduct of NOS reaction, and this citrulline may be recycled to arginine if AS and AL are present in the same cell, forming the citrulline-NO cycle.

Go back
605.0, 469.0
21.0, 21.0

p6

p6

cso30:i:ME_Hydrolysis

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m6*m63554*0.1

nodelay

--

true

0

false

PMID: 17513437 The major site of arginine metabolism in ureotelic animals is the liver, where arginine generated in the urea cycle is rapidly converted to urea and ornithine by arginase with no net synthesis of arginine PMID: 17513437 In contrast, arginine is hydrolyzed to urea and ornithine by arginase.

Go back
1054.0, 610.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m157177*m18*0.1

nodelay

--

true

0

false

PMID: 17513437 When iNOS is induced in various cells stimulated by bacterial LPS and cytokines, AS and sometimes AL are coinduced.

Go back
417.0, 561.0
21.0, 21.0

p3

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m20*m19*0.1

nodelay

--

true

0

false

PMID: 17513437 When iNOS is induced in various cells stimulated by bacterial LPS and cytokines, AS and sometimes AL are coinduced.

Go back
525.0, 517.0
21.0, 21.0

p3

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m21*m19*0.1

nodelay

--

true

0

false

PMID: 17513437 When iNOS is induced in various cells stimulated by bacterial LPS and cytokines, AS and sometimes AL are coinduced.

Go back
445.0, 392.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.2469504755443, 581.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 72.96138615824376

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
347.0, 62.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
549.7797550119576, 684.5015306487074

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.0, 675.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 1127.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 1015.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0464891333336, 713.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
643.104456000465, 335.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.5441748823466, 260.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 1020.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.0, 299.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 1176.3632612873491

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.0, 62.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
687.5550638913054, 257.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
195.59025949662302, 701.8403491461414

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
195.83554526686822, 305.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.56892908110547, 620.8446454055273

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
156.30924644797426, 77.99402068013433

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.0, 243.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 220.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 303.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.3306017655837, 316.8885676102462

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.57044805972896, 242.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.0, 343.3071142168176

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0, 332.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0, 406.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 341.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 490.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 449.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0, 620.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.7931034482758, 629.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.9978375455747, 692.1859962219901

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.0, 589.929823205461

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 511.61980619513406

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.79116155598257, 575.8159850243268

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 545.8358026777447

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 314.8587085313798

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.64814254032433, 303.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.4613089379535, 534.8859779854348

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 232.5685159055888

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 766.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 806.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
993.7839864320407, 822.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.0, 891.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
441.0, 956.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.906099411713, 870.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1052.0, 937.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 941.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.08910470500905, 408.3795279064105

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
993.3531602401445, 980.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.6564023547028, 971.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.9374896293892, 965.9981274384262

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
338.0469186324793, 957.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1056.0, 1086.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 1099.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.6518186410233, 1139.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.1589090381948, 610.9984215891375

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.86938393585103, 1071.4397209695528

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.0, 1027.7201327147384

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 400.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.9958675975589, 1216.2571018520116

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
279.21592049628157, 957.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0, 610.9681888062956

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.657888614785, 707.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 1018.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
777.0, 1051.7785148465887

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.9604042053605, 718.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.0, 222.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1060.0, 210.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.0, 251.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.5455257366611, 446.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.9459451369956, 274.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 644.9853479730496

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.0, 598.0527821846193

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.2387169431572, 324.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.6079254665552, 237.56298385301017

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 761.0100193633918

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 612.3928116564992

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.1705724012529, 439.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.9806921993136, 611.9393147798845

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.0, 749.3350101610727

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.0, 436.27569820671823

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
826.6051966868572, 513.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
190.82166944819664, 773.4870907442773

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
185.0, 605.0033414586218

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
192.47449803527903, 435.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
231.54683349878326, 660.170772073627

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
233.0, 598.6776569998606

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.88849023859564, 506.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
331.0, 233.22620265335163

c77

c77

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
600.1515741864623, 233.8306496698437

c78

c78

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
570.0, 808.5150819785126

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
581.0, 709.6193931775946

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 392.45914383554737

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.9333915735384, 260.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.9879072823045, 53.43970131829199

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.5634378434289, 57.60660852231165

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 61.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.6806329322063, 59.96887303244359

c85

c85

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
556.3506061265072, 55.157307329506445

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.0, 52.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.15740886950533, 62.45576245405968

c88

c88

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
231.84844214594295, 554.4585460028801

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
626.0, 610.4436087949382

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 481.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
220.0, 65.58495824721096

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
370.22443610809864, 480.79368379957384

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
303.0, 464.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 65.80739332227307

c94

c94

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
642.0, 887.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.0, 873.5895014325039

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
718.1313708498985, 260.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back