1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17702640.csml convertedTime:2009.07.01.11:07

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of the interferon regulatory factor (IRF) family in dendritic celldevelopment and function.
Authors Gabriele L, Ozato K.
Affiliation Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita,Viale Regina Elena 299, 00161 Roma, Italy. lucia.gabriele@iss.it
Abstract Dendritic cells (DCs) are powerful sensors of foreign pathogens as well ascancer cells and provide the first line of defence against infection. They alsoserve as a major link between innate and adaptive immunity. Immature DCs respondto incoming danger signals and undergo maturation to produce high levels ofproinflammatory cytokines including type I interferons (IFNs) to establishinnate immunity. They then present antigens to T lymphocytes to stimulatelasting specific immune responses. Recent studies point to the importance of DCsin the induction of peripheral tolerance. Transcription factors of the IRFfamily have emerged as crucial controllers of many aspects of DC activity,playing an essential role in the establishment of early innate immunity.Furthermore, eight of the nine members of the IRF family have been shown tocontrol either the differentiation and/or the functional activities of DCs. Inthis review, we focus on three aspects of DC properties that are under thecontrol of IRFs: (1) the development and differentiation, (2) maturation inresponse to toll-like receptor (TLR) signalling and the production ofanti-microbial cytokines, and (3) activation and expansion of lymphocytes togenerate protective or tolerogenic immune responses.
PMID 17702640
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010384:IRF-1 G010389:IL-1beta G010447:INDO G010533:CD8A G010657:IL-12 p40 G010691:CD40 G010713:IRF-7 G010859:CD86 G010915:IRF4 G011345:IL10 G012224:CD80 MO000000058:NF-kappaB MO000000065:RIP1 MO000000090:GM-CSFR MO000000099:GM-CSF MO000000212:TRAF6 MO000000213:IRAK-1 MO000000248:IKK MO000000276:AP-1 MO000005216:FLT3 MO000007185:IRF-8 MO000007685:IRF-1 MO000007690:IRF-2 MO000007694:IRF-3 MO000007697:IRF-4 MO000007700:IRF-5 MO000007702:IRF-7 MO000013122:STAT3 MO000016573:MyD88 MO000016608:IKK-i {activated} MO000016658:IFN Type I MO000016665:IFNgamma MO000016882:LPS MO000016899:FADD MO000016963:TRAF3 MO000017265:IL-12 MO000018132:CD14 MO000019331:TBK1 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000022131:MD-2 MO000022224:dsRNA MO000022528:TIRAP MO000037579:PU.1 MO000038482:IFNalpha, IFNbeta MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041456:IRF-3{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000062184:INDO MO000090399:FLT3L e1: e10: e11:IRF-4: PU.1 e12:IRF-8: PU.1 e13:IRF-1: IRF-8 e14:FLT3L: FLT3 e15:GM-CSF: GM-CSF e16: e17: e18: e19:STAT3 {activated} e2: e20:CD14: MD-2: TLR4 e21:NF-kappaB {activated} e22:1,25(OH)2D3 e23:ssRNA: TLR7 e24:ssRNA: TLR8 e25:CpG DNA: TLR9 e26:TLR ligand e27:TLR liagnd: TLRs e28:IFN- Type I e29:cytokines e3: e30:MHC antigen e31:TLR2 ligand : TLR2 e32:TLR2 ligand e33:TLR3 ligand e34:TLR3 ligand: TLR3 e35:LPS: CD14: MD-2: TLR4 e36:ssRNA e37:CpG DNA e38:ssRNA: TLR7: MyD88 e39:ssRNA: TLR8: MyD88 e4: e40:CpG DNA: TLR9: MyD88 e41:ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7 e42:ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7 e43:CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7 e44:IKK [activated} e45:IRF7: IRF-7 e47:IRF7: IRF-7 e48:NF-kappaB {nucleus} e49:IFN-alpha4 e5:IFN-alpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:RIG-1 e60: e61: e62: e63:LPS: CD14: MD-2: TLR4: MyD88: TIRAP e64:LPS: CD14: MD-2: TLR4: TRAM: TRIF e65:LPS: CD14: MD-2: TLR4: TRAM: TRIF: TRAF3: NAP1 e66:NAP1 e67:TLR3 ligand: TLR3: TRIF: TRAF3: NAP1 e68:TBK1 {activated} e69:IRF-5 {activated} e7: e70:MyD88: IRF-4 e71:ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5 e72:CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5 e73:LPS: CD14: MD-2: TLR4: MyD88: TIRAP: IRF-5 e74:NOS e75:Mda-5 e76:LGP2 e77:IL-12p35 e78:IPS-1 e79:IPS-1 {activated} e8: e80:IRF-7 e81:IKK-i e82:dsRNA: LGP2 e83:dsRNA: RIG-1 e84:dsRNA: Mda-5 e85:ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6 e86:ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6 e87:CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6 e9:

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
750.0, 1319.0
32.5, 32.5

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65 p66 p80 p96

p79 p92 p95

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
576.0, 1217.0
28.5, 28.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p58

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
547.0, 1220.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
798.0, 1483.0
24.0, 24.0

IRF-1

--

G010384

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m93359

10

false

infinite

0

unit false false false
TRANSFACG010384

--

Go back
515.0, 1236.0
30.0, 30.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p56

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
816.0, 1237.0
28.0, 28.0

INDO

--

G010447

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p17

p18

true true true true

csml-variable:Double

m93417

10

false

infinite

0

unit false false false
TRANSFACG010447

--

Go back
830.0, 1323.0
32.0, 32.0

CD8A

--

G010533

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p10

--

true true true true

csml-variable:Double

m93496

10

false

infinite

0

unit false false false
TRANSFACG010533

--

Go back
897.0, 1409.0
30.0, 30.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p9 p15 p16 p41 p42 p43 p59

p8 p44 p45 p46

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
600.0, 1453.0
28.0, 28.0

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p24

p28

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false
TRANSFACG010691

--

Go back
674.0, 1423.0
32.0, 32.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p68 p79

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
554.0, 1419.0
32.0, 32.0

CD86

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23

p28

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
838.0, 1363.0
32.0, 32.0

IRF4

--

G010915

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m93801

10

false

infinite

0

unit false false false
TRANSFACG010915

--

Go back
826.0, 1279.0
24.0, 24.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p4

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
529.0, 1390.0
25.0, 25.0

CD80

--

G012224

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22

p28

true true true true

csml-variable:Double

m95018

10

false

infinite

0

unit false false false
TRANSFACG012224

--

Go back
941.0, 978.0
34.0, 34.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
982.0, 535.0
32.0, 32.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1174.0, 1122.0
28.0, 28.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
1319.0, 1116.0
29.0, 29.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
556.0, 593.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
539.0, 515.0
25.0, 25.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
550.0, 903.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p54 p55

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
580.0, 1284.0
24.0, 24.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p102

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1176.0, 925.0
28.0, 28.0

FLT3

--

MO000005216

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m632

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000005216

--

Go back
966.0, 883.0
32.5, 32.5

IRF-8

--

MO000007185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3 p16 p17 p18 p19 p12 p69

true true true true

csml-variable:Double

m769

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
1102.0, 1218.0
28.0, 28.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p15 p19 p65 p66 p80 p92 p95 p96

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
1114.0, 699.0
32.0, 32.0

IRF-2

--

MO000007690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m974

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007690

--

Go back
602.0, 571.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77 p99

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
960.0, 801.0
28.0, 28.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p56 p57 p88

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
776.0, 557.0
28.0, 28.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86 p89 p90 p91

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
559.0, 636.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40 p100

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1055.0, 1004.0
30.0, 30.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
516.0, 449.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p36 p37 p72 p88

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
841.0, 546.0
26.0, 26.0

IKK-i {activated}

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p86 p99 p100

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
316.0, 1409.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p50 p51 p52 p12

p22 p23 p24 p27 p67 p68

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
914.0, 1531.0
32.0, 32.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93 p96

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1372.0, 1272.0
32.0, 32.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p10 p4 p17 p18 p31

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
992.0, 485.0
28.0, 28.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
463.0, 376.0
29.0, 29.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p74

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1047.0, 1468.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p44 p45 p46

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
998.0, 203.0
32.0, 32.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
620.0, 429.0
27.0, 27.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76 p78 p101

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
807.0, 916.0
29.0, 29.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p85

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
952.0, 229.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1164.0, 245.0
27.0, 27.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
276.0, 385.0
28.0, 28.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
329.0, 270.0
26.0, 26.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1003.0, 268.0
30.0, 30.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1319.0, 248.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p104 p105 p106

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
700.0, 357.0
27.0, 27.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
962.0, 843.0
24.0, 24.0

PU.1

--

MO000037579

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m15836

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000037579

--

Go back
1121.0, 770.0
26.0, 26.0

IFNalpha, IFNbeta

--

MO000038482

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m16692

10

false

infinite

0

unit false false false
TRANSPATHMO000038482

--

Go back
553.0, 554.0
26.0, 26.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p39 p40

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
548.0, 373.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73 p75

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
591.0, 324.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
689.0, 758.0
33.5, 33.5

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77 p99

p64 p66

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
322.0, 603.0
24.0, 24.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
313.0, 690.0
25.0, 25.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
316.0, 529.0
27.0, 27.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
947.0, 940.0
30.0, 30.0

INDO

--

MO000062184

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m37076

10

false

infinite

0

unit false false false
TRANSPATHMO000062184

--

Go back
1321.0, 910.0
25.0, 25.0

FLT3L

--

MO000090399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m63933

10

false

infinite

0

unit false false false
TRANSPATHMO000090399

--

Go back
234.94155537993342, 229.92910318445956
998.1628314986718, 1464.2757948646324

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
270.2755123330503, 278.75029134492155
943.3342895567345, 1340.6882103767334

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1119.5, 817.0
29.917680386602232, 36.6338943509415

IRF-4: PU.1

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1117.5, 859.0
32.3182802866189, 39.57340443259457

IRF-8: PU.1

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1116.625, 642.5
27.27007998666889, 33.39193467755374

IRF-1: IRF-8

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1179.625, 973.5
29.10727378770205, 35.64155974004332

FLT3L: FLT3

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p6 p11

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1163.625, 1032.5
29.63801866355607, 36.29145142476254

GM-CSF: GM-CSF

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p6 p13

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
323.1159994690232, 449.72772267839883
202.67411298427905, 338.36271405002543

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
319.71670490963913, 444.38313769366437
204.96326778298197, 342.184438586843

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
327.8733241044507, 457.6700358409346
197.9167883488515, 330.4204008874897

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
1111.0, 924.0
30.0, 30.0

STAT3 {activated}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p3

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
234.94155537993342, 229.92910318445956
998.1628314986718, 1464.2757948646324

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
906.25, 233.0
31.853459350339513, 44.44668746559002

CD14: MD-2: TLR4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

p31

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
939.0, 1039.0
34.0, 34.0

NF-kappaB {activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p48 p102

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1030.0, 1108.0
40.39529015979814, 22.890664423885614

1,25(OH)2D3

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3 p14

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
321.625, 563.5
24.91030661556407, 30.50241626395601

ssRNA: TLR7

--

e23

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p32

p35

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
325.625, 651.5
25.40022496250625, 31.102316280619895

ssRNA: TLR8

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p36

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
360.625, 762.5
27.629353441093148, 33.83186135644059

CpG DNA: TLR9

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p34

p37 p92 p95 p96

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1163.5, 171.375
36.56414762741651, 23.766695957820737

TLR ligand

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1050.625, 228.5
30.029953341109817, 36.77137143809365

TLR liagnd: TLRs

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21 p25 p26

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
500.5, 1344.0
42.6643598615917, 22.75432525951557

IFN- Type I

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47 p69 p87

p21 p50 p51 p52 p12

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
785.0, 1198.0
34.671280276816596, 18.491349480968857

cytokines

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p84

p26 p85

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
254.9048120099068, 250.09819126799442
958.236318238725, 1423.9376186975642

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
614.0, 1492.0
39.602076124567475, 21.12110726643599

MHC antigen

--

e30

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

p28

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
275.5, 329.0
29.860523246125652, 36.56390601566407

TLR2 ligand : TLR2

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p29

p43 p46

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
199.0, 397.25
30.0, 19.5

TLR2 ligand

--

e32

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
355.0, 117.25
30.0, 19.5

TLR3 ligand

--

e33

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p30

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
381.75, 256.0
24.5, 30.0

TLR3 ligand: TLR3

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p42 p45 p70 p75

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
643.75, 213.0
35.89876687218797, 43.95767372104649

LPS: CD14: MD-2: TLR4

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p41 p44 p72 p73 p80

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
98.0, 563.75
40.44145873320538, 22.242802303262955

ssRNA

--

e36

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p32 p33

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
97.0, 647.75
41.0913140311804, 14.381959910913139

CpG DNA

--

e37

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p34

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
316.25, 480.0
26.921361717746375, 37.56469076894843

ssRNA: TLR7: MyD88

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p35

p39

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
453.25, 461.0
25.429895393650213, 35.48357496788402

ssRNA: TLR8: MyD88

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p36

p38

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
291.83683677535777, 285.39409541418036
884.3722687078235, 1353.3458104051906

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
411.25, 775.0
22.44696274545788, 31.321343365755183

CpG DNA: TLR9: MyD88

--

e40

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p37

p40

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
339.25, 419.0
28.610111947146265, 39.9210864378785

ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39 p82

p52 p53 p60 p87 p89

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
509.25, 585.0
25.564048449256745, 35.67076527803267

ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7

--

e42

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p38

p51 p54 p61

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
441.25, 753.0
25.564048449256745, 35.67076527803267

CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p40 p83

p50 p55 p62 p90

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
498.0, 907.0
32.0, 32.0

IKK [activated}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p54 p55

p56 p57 p58 p59

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
607.0, 807.5
37.52867780237472, 23.142684644797747

IRF7: IRF-7

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p60 p61 p62 p103

p63

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
619.0, 1259.5
37.52867780237472, 23.142684644797747

IRF7: IRF-7

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

p63

p47 p49 p65

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
895.0, 1159.0
34.0, 34.0

NF-kappaB {nucleus}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p14 p47

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
666.0, 1348.0
40.173010380622834, 21.42560553633218

IFN-alpha4

--

e49

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p49 p64

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
644.0, 1449.0
28.0, 28.0

IFN-alpha

--

e5

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p67

--

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
435.1277391225187, 1064.5715939277611
550.7174422798197, 504.58969874085597

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
494.60932506708036, 1076.5296362298807
322.0209997688331, 489.0479215722463

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
442.3065512192762, 1071.3063640341584
536.3598180863053, 491.12015852806076

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
443.3320958045271, 1072.3424825120662
534.3087289158027, 489.0479215722463

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
435.1277391225187, 1064.5715939277611
550.7174422798197, 504.58969874085597

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
435.1277391225187, 1064.5715939277611
550.7174422798197, 504.58969874085597

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
443.3320958045271, 1072.3424825120662
534.3087289158027, 489.0479215722463

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
837.1412165409341, 1271.7952895092212
34.40579987441296, 31.467437463678348

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
746.8932930388414, 1416.8518764162434
97.42673559885074, 89.10618910002798

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
435.1277391225187, 1064.5715939277611
550.7174422798197, 504.58969874085597

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
983.5, 332.125
29.000000000000004, 21.749999999999996

RIG-1

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p105

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
564.9287415941108, 1288.807086589192
17.440412202721355, 8.48381532622913

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
564.3463568641521, 1263.5063416859632
59.694434820745705, 108.55784731734413

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
589.3889002523676, 1334.1130716484638
9.318155679335902, 9.414230661666691

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
742.25, 201.0
30.98541016700312, 43.2354560469811

LPS: CD14: MD-2: TLR4: MyD88: TIRAP

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72 p81

p91

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
591.25, 225.0
37.14855936869151, 51.835199119104416

LPS: CD14: MD-2: TLR4: TRAM: TRIF

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

p77 p74

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
538.25, 234.0
30.709212699577904, 42.85006423196917

LPS: CD14: MD-2: TLR4: TRAM: TRIF: TRAF3: NAP1

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

p78

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
465.0, 330.0
26.0, 26.0

NAP1

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p74

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
Affymetrix1452196_a_at
EnsemblENSMUSG00000027002
MGDNckap1
ProteomeHumanPSD/Nckap1
RefSeqNM_016965
TRANSPATHMO000079906
UnigeneMm.25203
UniProtP28660

--

Go back
424.25, 243.0
34.7811525050468, 48.53184070471646

TLR3 ligand: TLR3: TRIF: TRAF3: NAP1

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

p76 p86

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
650.0, 478.0
27.0, 27.0

TBK1 {activated}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76 p78 p101

p77 p86 p99 p100

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
768.0, 729.0
28.0, 28.0

IRF-5 {activated}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p81 p82 p83 p86

p52 p84 p85 p87

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
272.685246372948, 235.67413729625179
954.4115350109844, 1366.3201902964274

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
867.5, 505.0
29.117480419930015, 35.654057657057166

MyD88: IRF-4

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

p89 p90 p91

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
488.5, 524.0
26.83850247751881, 37.44907322444485

ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5

--

e71

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p89

p82

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
458.5, 710.0
30.058175812075607, 41.94164066801247

CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p83

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
784.5, 238.0
35.140209212699574, 49.032850064231965

LPS: CD14: MD-2: TLR4: MyD88: TIRAP: IRF-5

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p91

p81

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
712.0, 1517.0
28.0, 28.0

NOS

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p92

--

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
959.125, 405.5
21.49522036627088, 34.85711410746629

Mda-5

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p104

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1087.5, 342.125
28.952505534312746, 17.854045079492856

LGP2

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p106

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
779.5, 1517.0
37.83737024221453, 20.179930795847753

IL-12p35

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p95

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1083.25, 462.5
14.428905519176803, 33.2974742750234

IPS-1

--

e78

cso30:c:Protein

cso30:i:CC_MitochondrialMatrix

--

--

p94 p97 p98

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1083.25, 546.5
14.428905519176803, 33.2974742750234

IPS-1 {activated}

--

e79

cso30:c:Protein

cso30:i:CC_MitochondrialMatrix

--

p94 p97 p98

p99 p100 p101 p102

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
276.09498041284576, 259.78836836925655
915.5783580847273, 1343.1267782556724

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
819.0, 800.0
30.0, 30.0

IRF-7

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p100

p103

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
913.0, 478.0
26.0, 26.0

IKK-i

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1137.5, 380.0
24.00599900016664, 29.395100816530572

dsRNA: LGP2

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p106

p98

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1069.75, 376.0
24.5, 30.0

dsRNA: RIG-1

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p105

p97

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1021.75, 396.0
24.5, 30.0

dsRNA: Mda-5

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p104

p94

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
400.5, 424.0
26.68067535327583, 37.228849330152315

ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
504.5, 631.0
30.25545971737933, 42.216920535878145

ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
500.5, 676.0
27.832813360249588, 38.8364837584878

CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
285.1876045192397, 283.90259944226125
911.3982406538516, 1325.5120071159681

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1060.0, 821.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007697 MO000037579

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m978*m15836*0.1

nodelay

--

true

0

false

PMID: 17702640, 11846986 They are expressed preferentially in hematopoietic cells, of both myeloid and lymphoid origin, and interact with the same partner transcription factors such as PU.1, an immune cell specific protein of the Ets family, although the two factors associate with distinct factors as well.

Go back
874.0, 1243.0
23.0, 23.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G010533

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17702640 IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8¦Á in response to LPS.

Go back
822.0, 703.0
23.0, 23.0

p100

p100

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e79 e68 MO000016608

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c298 : 1
stoichiometry:c300 : 1
stoichiometry:c301 : 1
stoichiometry:c296 : 1

m980*m80*m69*m1599*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

Go back
703.0, 419.0
25.0, 25.0

p101

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e79

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c310 : 1
stoichiometry:c304 : 1

m3902*m80*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.

Go back
913.0, 546.0
25.0, 25.0

p102

p102

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e81 MO000016899 MO000000065 e79 e21 MO000000276

MO000016608

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c307 : 1
stoichiometry:c308 : 1
stoichiometry:c309 : 1
stoichiometry:c312 : 1
stoichiometry:c314 : 1
stoichiometry:c306 : 1

m84*m1814*m83*m80*m22*m219*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.

Go back
753.0, 806.0
25.0, 25.0

p103

p103

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e80

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c315 : 1
stoichiometry:c316 : 1

m82*0.1

nodelay

--

true

0

false

PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

Go back
931.0, 316.0
21.0, 21.0

p104

p104

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e75

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c319 : 1
stoichiometry:c320 : 1

m119368*m76*0.1

nodelay

--

true

0

false

PMID: 17702640 RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.

Go back
1026.0, 343.0
23.0, 23.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e6

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c323 : 1
stoichiometry:c322 : 1

m119368*m6*0.1

nodelay

--

true

0

false

PMID: 17702640 RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.

Go back
1131.0, 340.0
21.0, 21.0

p106

p106

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e76

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c292 : 1
stoichiometry:c324 : 1
stoichiometry:c325 : 1

m119368*m77*0.1

nodelay

--

true

0

false

PMID: 17702640 RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.

Go back
1114.0, 979.0
23.0, 23.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 MO000013122

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m15*m1360*0.1

nodelay

--

true

0

false

PMID: 17702640, 16474425, 14670306 As STAT-3 is required for Flt3L-dependent differentiation of pDCs and CD8¦Á+ DCs, it may be suggested that IRF-8, acting downstream of the Flt3L/STAT3 pathway, specifically regulates the differentiation of these DC subsets.

Go back
397.0, 1234.0
25.0, 25.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000007185 e28

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c195 : 1
stoichiometry:c197 : 1

m769*m29*0.1

nodelay

--

true

0

false

PMID: 17702640 Interestingly, our evidence indicates that not only IRF-3/7, IRF-8 plays a critical role in the production of type I IFNs both in pDCs and cDCs.

Go back
1020.0, 1033.0
27.0, 27.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e15

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c36 : 1

m14*m16*0.1

nodelay

--

true

0

false

PMID: 17702640, 16272311 Consistent with this finding, it has been reported that this growth factor specifically stimulates IRF-4 expression in human monocytes-derived DCs through the activation of NF-kappaB.

Go back
909.0, 1222.0
25.0, 25.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48 e22

G010915

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c41 : 1
stoichiometry:c39 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 17702640, 16272311 Consistent with this finding, it has been reported that this growth factor specifically stimulates IRF-4 expression in human monocytes-derived DCs through the activation of NF-kappaB. PMID: 17702640, 15829558 Moreover, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), a potent inhibitor of DC differentiation, completely abolishes in vitro-induced up-regulation of IRF-4 in monocytes-derived DCs and blood mDCs but not in pDCs.

Go back
906.0, 1295.0
23.0, 23.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007685

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c43 : 1

m970*0.1

nodelay

--

true

0

false

PMID: 17702640 In addition, IRF-1, like IRF-8 positively regulates the expression of some proinflammatory cytokines, such as IL-12p40.

Go back
930.0, 1271.0
23.0, 23.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007185

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17702640 In addition, IRF-1, like IRF-8 positively regulates the expression of some proinflammatory cytokines, such as IL-12p40.

Go back
838.0, 1155.0
23.0, 23.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882 MO000007185

G010447

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m155666*m769*0.1

nodelay

--

true

0

false

PMID: 17702640, 16339401 Intriguingly, IRF-8 has been shown to be required for the induction of the enzyme indoleamine 2,3-dioxygenase, an essential component of the tolerogenic program of murine CD8¦Á+ DCs and LPS-stimulated, monocyte-derived human DCs.

Go back
1018.0, 950.0
27.0, 27.0

p18

p18

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000016882 MO000007185 G010447

MO000062184

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m155666*m769*m93417*0.1

nodelay

--

true

0

false

PMID: 17702640, 16339401 Intriguingly, IRF-8 has been shown to be required for the induction of the enzyme indoleamine 2,3-dioxygenase, an essential component of the tolerogenic program of murine CD8¦Á+ DCs and LPS-stimulated, monocyte-derived human DCs.

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1070.0, 727.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007185 MO000007685

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m769*m970*0.1

nodelay

--

true

0

false

PMID: 17702640, 16597464 This finding mirrors the ability of IRF-1 and IRF-8 to form heterocomplexes and cooperatively regulate the expression of many genes involved in the onset of innate immunity.

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1073.0, 886.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007185 MO000037579

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m769*m15836*0.1

nodelay

--

true

0

false

PMID: 17702640, 11846986 They are expressed preferentially in hematopoietic cells, of both myeloid and lymphoid origin, and interact with the same partner transcription factors such as PU.1, an immune cell specific protein of the Ets family, although the two factors associate with distinct factors as well.

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1102.0, 171.0
23.0, 23.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000019395

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m27*m3962*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.

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360.0, 1353.0
27.0, 27.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e28 e27

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c59 : 1

m29*m28*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765 Type I IFNs are the major cytokines that confer early protection against incoming pathogens, as they broadly elicit anti-viral and anti-microbial agents.

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486.0, 1415.0
23.0, 23.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016658

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c65 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640 Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.

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510.0, 1435.0
23.0, 23.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016658

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c66 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640 Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.

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542.0, 1463.0
23.0, 23.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

MO000016658

G010691

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c67 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640 Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.

Go back
822.0, 1119.0
23.0, 23.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c69 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.

Go back
814.0, 999.0
23.0, 23.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e29 e27

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c70 : 1

m30*m28*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.

Go back
569.0, 1498.0
25.0, 25.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016658

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640 Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.

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168.0, 1497.0
27.0, 27.0

p28

p28

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

G012224 G010859 G010691 e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m95018*m93745*m93612*m31*0.1

nodelay

--

true

0

false

PMID: 17702640 Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.

Go back
202.0, 335.0
23.0, 23.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e32 MO000019397

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m33*m3964*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

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1319.0, 792.0
29.0, 29.0

p3

p3

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e11 e12 MO000007685 MO000038482 MO000007690 MO000007185 e19 e22

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c55 : 1
stoichiometry:c68 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c40 : 1

m11*m12*m974*m769*m20*0.1

nodelay

--

true

0

false

PMID: 17702640, 16966383 In the past few years IRF-4 and IRF-8 first, and IRF-1 next, have emerged as key players of DC development. PMID: 17702640, 16474425, 14670306 As STAT-3 is required for Flt3L-dependent differentiation of pDCs and CD8¦Á+ DCs, it may be suggested that IRF-8, acting downstream of the Flt3L/STAT3 pathway, specifically regulates the differentiation of these DC subsets. PMID: 17702640, 15829558 Moreover, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), a potent inhibitor of DC differentiation, completely abolishes in vitro-induced up-regulation of IRF-4 in monocytes-derived DCs and blood mDCs but not in pDCs. PMID: 17702640, 16172134 Moreover, at variance with IRF-4, IRF-1 appears to function as a negative regulator of CD4+CD8¦Á¡Ý DC differentiation. In support of this finding, IRF-4 is shown to be a natural antagonist of IRF-1 in immune cells including DCs. PMID: 17702640, 17018853, 10891453 Thus, in accordance with the reports indicating that IFNalpha/beta exert an inhibitory effect on human DC maturation [33] and [34], IRF-2 may protect developing DCs, especially myeloid lineage-related subsets, from detrimental effects of high levels of IFNalpha/beta such as maturation arrest.

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357.0, 158.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e33 MO000019398

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m34*m3965*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
909.0, 134.0
25.0, 25.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e20

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c202 : 1
stoichiometry:c91 : 1

m155666*m21*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.

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165.0, 530.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e36 MO000042126

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c97 : 1

m37*m19940*0.1

nodelay

--

true

0

false

PMID: 17702640, 15829275 TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.

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164.0, 601.0
27.0, 27.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e36 MO000042007

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m37*m19823*0.1

nodelay

--

true

0

false

PMID: 17702640, 15829275 TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.

Go back
174.0, 695.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e37 MO000042012

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m38*m19828*0.1

nodelay

--

true

0

false

PMID: 17702640, 15829275 TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.

Go back
390.0, 563.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e23 MO000016573

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m24*m1572*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

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394.0, 659.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e24 MO000016573

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m25*m1572*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

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381.0, 722.0
25.0, 25.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e25 MO000016573

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m26*m1572*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

Go back
421.0, 498.0
25.0, 25.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007702 e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c117 : 1
stoichiometry:c120 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m184*m17258*m183*m980*m40*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

Go back
441.0, 554.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007702 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c116 : 1
stoichiometry:c119 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m184*m17258*m183*m980*m39*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

Go back
861.0, 1182.0
25.0, 25.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c10 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17702640 Of note, the entire splenic DC population from IRF-1 KO mice fail to undergo maturation in response to viral or bacterial stimuli, such as New Castle disease (NDV) virus and LPS, and express high levels of tolerogenic cytokines such as IL-10, accounting for the induction of suppressor activity in allogeneic CD4+CD25+ regulatory T (Treg) cells.

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455.0, 603.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000000213 MO000039077 MO000000212 MO000007702 e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c118 : 1
stoichiometry:c121 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m184*m17258*m183*m980*m41*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.

Go back
1004.0, 1292.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c128 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
932.0, 1292.0
23.0, 23.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c129 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
938.0, 1351.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e31

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
982.0, 1423.0
23.0, 23.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e35

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c140 : 1
stoichiometry:c134 : 1

m93589*m36*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
953.0, 1450.0
26.0, 26.0

p45

p45

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e34

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c141 : 1
stoichiometry:c135 : 1

m93589*m35*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
937.0, 1486.0
25.0, 25.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e31

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c142 : 1
stoichiometry:c136 : 1

m93589*m32*0.1

nodelay

--

true

0

false

PMID: 17702640, 15976491 Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.

Go back
570.0, 1343.0
23.0, 23.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e47 MO000000276 e48

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c151 : 1
stoichiometry:c146 : 1

m48*m219*m49*0.1

nodelay

--

true

0

false

PMID: 17702640, 11592079, 15771572 Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12. PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.

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970.0, 1115.0
23.0, 23.0

p48

p48

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

e21

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.

Go back
647.0, 1308.0
22.0, 22.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c187 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

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1322.0, 979.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000005216 MO000090399

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m632*m63933*0.1

nodelay

--

true

0

false

PMID: 17702640 The Flt3 ligand (Flt3L) expands preferentially pDCs and CD8¦Á+ DCs, in which IRF-8 expression is predominant.

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318.0, 1327.0
23.0, 23.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e43 e28

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c155 : 1
stoichiometry:c143 : 1

m44*m29*0.1

nodelay

--

true

0

false

PMID: 17702640, 11592079, 15771572 Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.

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338.0, 1287.0
23.0, 23.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e42 e28

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c156 : 1
stoichiometry:c144 : 1

m43*m29*0.1

nodelay

--

true

0

false

PMID: 17702640, 11592079, 15771572 Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.

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366.0, 1259.0
23.0, 23.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 e28 e69

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c157 : 1
stoichiometry:c253 : 1
stoichiometry:c145 : 1

m42*m29*m70*0.1

nodelay

--

true

0

false

PMID: 17702640, 11592079, 15771572 Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12. PMID: 17702640, 15695821 Given the evidence that human IRF-5 selectively regulates TLR7-mediated type I IFN induction, IRF-5 may play a species-specific function.

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553.0, 802.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e41

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c172 : 1
stoichiometry:c159 : 1

m207*m42*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.

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515.0, 808.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c171 : 1
stoichiometry:c161 : 1

m207*m43*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.

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483.0, 832.0
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c170 : 1
stoichiometry:c163 : 1

m207*m44*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.

Go back
518.0, 1187.0
23.0, 23.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44 MO000007697

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c318 : 1
stoichiometry:c62 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40. PMID: 17702640, 16243976 Lastly, a recent report shows that IRF-4 negatively regulates production of proinflammatory cytokines such as IL-6 and TNFalpha in response to TLR stimulation, suggesting that this factor prevents harmful effects of endotoxin and curtails excess inflammatory responses.

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550.0, 1171.0
23.0, 23.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44 MO000007697

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c317 : 1
stoichiometry:c63 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40. PMID: 17702640, 16243976 Lastly, a recent report shows that IRF-4 negatively regulates production of proinflammatory cytokines such as IL-6 and TNFalpha in response to TLR stimulation, suggesting that this factor prevents harmful effects of endotoxin and curtails excess inflammatory responses.

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588.0, 1165.0
19.0, 19.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c64 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.

Go back
850.0, 1427.0
23.0, 23.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e44

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17702640, 17276695 TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.

Go back
1319.0, 1004.0
29.0, 29.0

p6

p6

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e14 e15

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c20 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 17702640 The Flt3 ligand (Flt3L) expands preferentially pDCs and CD8¦Á+ DCs, in which IRF-8 expression is predominant. PMID: 17702640 Thus, the differentiation and functions of Flt3L-induced DC subsets depend on IRF-8 activity. PMID: 17702640, 15728463 Whereas, GM-CSF selectively promotes the differentiation of CD8¦Á¡Ý DCs that predominantly express IRF-4.

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594.0, 507.0
23.0, 23.0

p60

p60

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e41

e45 e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c175 : 1
stoichiometry:c328 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.

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579.0, 687.0
25.0, 25.0

p61

p61

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e42

e45 e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c176 : 1
stoichiometry:c178 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.

Go back
562.0, 763.0
23.0, 23.0

p62

p62

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e43

e45 e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c177 : 1
stoichiometry:c179 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.

Go back
661.0, 922.0
25.0, 25.0

p63

p63

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17702640, 15361868 Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

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674.0, 1271.0
23.0, 23.0

p64

p64

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c188 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner. PMID: 17702640 Similarly, TLR3 transmits signals through Trif to activate IRF-3, which then mediates primary IFNbeta and IFN-alpha4 induction. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

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713.0, 1317.0
21.0, 21.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47 MO000007685

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c332 : 1
stoichiometry:c189 : 1

m48*m970*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes. PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

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708.0, 1244.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456 MO000007685

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c330 : 1
stoichiometry:c190 : 1

m19324*m970*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner. PMID: 17702640 Similarly, TLR3 transmits signals through Trif to activate IRF-3, which then mediates primary IFNbeta and IFN-alpha4 induction. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes. PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

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629.0, 1390.0
25.0, 25.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016658

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c191 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.

Go back
675.0, 1372.0
21.0, 21.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016658

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c192 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 17702640, 17113765, 16474425, 12702806 Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFN¦Â and IFN¦Á4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.

Go back
530.0, 1291.0
23.0, 23.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007185

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c196 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 17702640 Interestingly, our evidence indicates that not only IRF-3/7, IRF-8 plays a critical role in the production of type I IFNs both in pDCs and cDCs.

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1321.0, 1038.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000099 MO000000090

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 17702640, 15728463 Whereas, GM-CSF selectively promotes the differentiation of CD8¦Á¡Ý DCs that predominantly express IRF-4.

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403.0, 88.0
30.0, 30.0

p70

p70

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e34

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17702640, 15711573 TLR3-mediated signalling triggers the maturation of immature CD8¦Á+ DCs that become competent to mediate cross-priming of T cells.

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885.0, 318.0
25.0, 25.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000022131 MO000018132

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m3961*m6438*m2828*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.

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705.0, 298.0
25.0, 25.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e35 MO000016573

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c206 : 1
stoichiometry:c205 : 1

m6810*m36*m1572*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.

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666.0, 299.0
23.0, 23.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 MO000041125 e35

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m19005*m18998*m36*0.1

nodelay

--

true

0

false

PMID: 17702640 Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.

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520.0, 329.0
27.0, 27.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 e64 MO000016963

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m67*m65*m1872*0.1

nodelay

--

true

0

false

PMID: 17702640 In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.

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401.0, 330.0
25.0, 25.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e66 e34 MO000016963

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c213 : 1
stoichiometry:c217 : 1

m18998*m67*m35*m1872*0.1

nodelay

--

true

0

false

PMID: 17702640 In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.

Go back
527.0, 412.0
21.0, 21.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m3902*m68*0.1

nodelay

--

true

0

false

PMID: 17702640 In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.

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662.0, 575.0
23.0, 23.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e68 e64

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1
stoichiometry:c222 : 1

m977*m69*m65*0.1

nodelay

--

true

0

false

PMID: 17702640 The latter two molecules mediate the activation of IRF-3. PMID: 17702640 In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.

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553.0, 478.0
25.0, 25.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e65

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c228 : 1

m3902*m66*0.1

nodelay

--

true

0

false

PMID: 17702640 In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.

Go back
715.0, 1384.0
21.0, 21.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

G010228

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c230 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 17702640 The secreted IFNs, particularly IFNb, stimulate the expression of IFN-inducible genes including IRF-7.

Go back
992.0, 1385.0
27.0, 27.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 MO000016882

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c22 : 1

m93589*m155666*0.1

nodelay

--

true

0

false

PMID: 17702640 IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8¦Á in response to LPS.

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756.0, 1232.0
23.0, 23.0

p80

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35 MO000007685

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c242 : 1
stoichiometry:c232 : 1

m36*m970*0.1

nodelay

--

true

0

false

PMID: 17702640 TLR4 is expressed on the plasma membrane and is the only receptor that can mediate the induction of IFNbeta, but not IFNalpha, upon recognition of non-nucleic acid ligands such as LPS. PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

Go back
730.0, 663.0
23.0, 23.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73

e69 e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c235 : 1
stoichiometry:c180 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17702640, 15665823 It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.

Go back
634.0, 675.0
24.0, 24.0

p82

p82

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e71

e69 e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c237 : 1
stoichiometry:c240 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17702640, 15665823 It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.

Go back
638.0, 731.0
23.0, 23.0

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72

e69 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c239 : 1
stoichiometry:c329 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 17702640, 15665823 It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.

Go back
791.0, 1092.0
21.0, 21.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e69

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c243 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 17702640, 15665823 It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.

Go back
761.0, 958.0
25.0, 25.0

p85

p85

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e29 e69

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c244 : 1

m30*m70*0.1

nodelay

--

true

0

false

PMID: 17702640, 15665823 It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.

Go back
716.0, 505.0
27.0, 27.0

p86

p86

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e67 e68 MO000016608

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c249 : 1

m979*m68*m69*m1599*0.1

nodelay

--

true

0

false

PMID: 17702640, 16751392 Moreover, IRF-5 is shown to be essential for TLR3 signalling, which does not utilize MyD88. A recent report indicates that IRF-5 is activated when TBK1 or IKKi/epsilon is coexpressed.

Go back
489.0, 1277.0
21.0, 21.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41 e69

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c254 : 1

m42*m70*0.1

nodelay

--

true

0

false

PMID: 17702640, 15695821 Given the evidence that human IRF-5 selectively regulates TLR7-mediated type I IFN induction, IRF-5 may play a species-specific function.

Go back
834.0, 451.0
23.0, 23.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000007697

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m1572*m978*0.1

nodelay

--

true

0

false

PMID: 17702640, 16236719 In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.

Go back
391.0, 380.0
22.0, 22.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 e41 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1
stoichiometry:c265 : 1
stoichiometry:c262 : 1

m979*m42*0.1

nodelay

--

true

0

false

PMID: 17702640, 16236719 In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.

Go back
871.0, 1327.0
25.0, 25.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c23 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 17702640 IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8¦Á in response to LPS.

Go back
605.0, 610.0
25.0, 25.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 e43 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c266 : 1
stoichiometry:c241 : 1

m979*m44*0.1

nodelay

--

true

0

false

PMID: 17702640, 16236719 In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.

Go back
823.0, 348.0
21.0, 21.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007700 e63 e70

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c267 : 1
stoichiometry:c270 : 1
stoichiometry:c268 : 1

m979*m64*0.1

nodelay

--

true

0

false

PMID: 17702640, 16236719 In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.

Go back
662.0, 1519.0
23.0, 23.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearEnvelopeLumen

--

G010228 MO000007685 e25

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c272 : 1
stoichiometry:c274 : 1
stoichiometry:c271 : 1

m93217*m970*m26*0.1

nodelay

--

true

0

false

PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

Go back
843.0, 1484.0
21.0, 21.0

p93

p93

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c278 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 17702640 In addition, pre-treatment of DCs with IFN-gamma, a strong inducer of IRF-1, leads to a robust IFNbeta induction upon CpG-B treatment.

Go back
1019.0, 452.0
21.0, 21.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 e84

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c321 : 1
stoichiometry:c289 : 1

m79*m87*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.

Go back
735.0, 1479.0
25.0, 25.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

G010228 MO000007685 e25

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c273 : 1
stoichiometry:c275 : 1
stoichiometry:c277 : 1

m93217*m970*m26*0.1

nodelay

--

true

0

false

PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

Go back
783.0, 1380.0
21.0, 21.0

p96

p96

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665 e25 MO000007685

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c286 : 1
stoichiometry:c331 : 1
stoichiometry:c281 : 1

m1639*m26*m970*0.1

nodelay

--

true

0

false

PMID: 17702640 In addition, pre-treatment of DCs with IFN-gamma, a strong inducer of IRF-1, leads to a robust IFNbeta induction upon CpG-B treatment. PMID: 17702640 It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.

Go back
1050.0, 431.0
23.0, 23.0

p97

p97

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 e83

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c326 : 1
stoichiometry:c287 : 1

m79*m86*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.

Go back
1099.0, 420.0
21.0, 21.0

p98

p98

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 e82

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c276 : 1
stoichiometry:c327 : 1
stoichiometry:c280 : 1

m79*m85*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.

Go back
857.0, 626.0
25.0, 25.0

p99

p99

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e79 e68 MO000016608

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c297 : 1
stoichiometry:c299 : 1
stoichiometry:c302 : 1
stoichiometry:c294 : 1

m977*m80*m69*m1599*0.1

nodelay

--

true

0

false

PMID: 17702640 These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway. PMID: 17702640, 16979567 These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.

Go back
988.0, 818.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.8089875327071, 1207.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
197.0, 711.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.0, 576.3716911948197

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0242352669091, 475.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.5402546255177, 518.7710985682476

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 668.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
417.1104190710256, 477.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 503.63500589716267

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 754.3292586792176

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.5660121448254, 477.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 747.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.8719938569436, 1198.4253816037265

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
473.43481668836745, 533.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 567.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.9229677525924, 514.1075116213301

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.37437966436295, 519.1013746251994

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.51724137931035, 540.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.13576066880637, 573.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.5638765346137, 573.6053352508114

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.52586312860234, 523.6274302184635

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.9662808700979, 608.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.5571660728507, 579.5829655347882

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.474532132279, 1237.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.65685424949237, 528.6568542494924

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.599030549249, 622.500946763044

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 506.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.9339663261524, 463.2972991267998

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.65685424949237, 493.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 523.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 635.7324924628942

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.7012898424761, 628.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.2222414915448, 1315.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.0561816280776, 1315.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.0, 944.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.2573723617468, 1374.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
293.0, 54.646507841906896

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.0, 71.0363471242232

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 94.52299919505367

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1005.0, 1443.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.0, 1466.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
962.0, 1486.1183222219963

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 1426.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
927.0, 1435.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 1439.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1334.0, 935.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 107.09907726721485

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.0, 82.73500539322072

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.0, 62.66784898457695

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
330.0, 1350.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.2763675214904, 1310.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.4032992908765, 1282.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 1355.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.4376015698018, 1283.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
585.3517105208867, 1308.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
354.92382014322794, 621.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1217.0, 991.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.7000403914196, 789.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0302696207102, 1185.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
355.0, 459.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
962.0, 1073.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.531325116055, 1135.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
348.97372377676186, 1340.647865056862

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.61622849028214, 1305.448073443305

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
395.89702849071364, 1281.0535167445423

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.0, 835.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.4324545165463, 827.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1209.0, 994.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0056408699137, 836.4139141457872

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.9169928638811, 829.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.4792800701431, 858.829021351216

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 853.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.0, 939.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.0, 939.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.0, 939.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
525.0, 939.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
873.0, 1431.24

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
368.0, 443.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1334.0, 1071.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 789.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.0, 621.0

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
365.0, 459.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 621.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 771.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0, 530.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 712.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.0, 784.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.6796656369347, 666.4025068970706

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.820821330685, 720.3843309514476

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1202.0, 1063.0128743242792

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0, 251.99487849898924

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 831.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.8639275108538, 947.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 1283.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.3170784203336, 792.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
655.0, 1283.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 792.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
666.0, 1330.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
686.0, 1294.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 1330.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1201.0, 1051.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 1267.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 1415.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 1393.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 1404.5042584356408

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 1384.8887246059512

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.7853683769801, 1264.5253518207114

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
528.9711254108329, 1314.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.3432448658572, 1259.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 125.91728479200285

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.4333130260619, 289.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 839.589299422362

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1193.0, 1023.6167322298229

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
915.7540848926742, 234.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.0, 284.62584510159456

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.0, 167.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.0, 330.98619498539995

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 257.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 251.31049238896205

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.0, 327.02579693004

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 318.8272045497486

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 323.38600343861515

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 257.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.0, 991.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.0402649471412, 272.24549324356997

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.0, 505.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.0, 277.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
432.3792510848185, 356.8275413614843

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.67291803677136, 349.26413974855546

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.0, 343.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.0, 286.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 299.50674493453687

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.8318433579009, 426.631634032896

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 428.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.0, 1412.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 292.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.0, 587.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 598.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.0, 343.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0779153868801, 273.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 360.20633098764773

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 284.795129565557

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.5098677696539, 453.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 491.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 277.0

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.0, 1352.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.1214751973158, 1405.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.5322305830965, 1352.0

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.2498780190218, 1255.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 257.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 556.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 686.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.0, 732.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 692.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
793.0, 376.83322708911174

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 743.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 1405.0242219551483

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
374.0966454134866, 456.17985662950366

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.4, 633.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.9944847126166, 1232.0

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.0, 1113.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 949.0335858293437

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.9604445215764, 990.9421373899584

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
774.2784381656917, 757.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.0, 757.0

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.009319187599, 535.2809168618294

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 532.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.9579463911215, 1290.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.0, 282.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 497.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.6048436519278, 525.4832142536907

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
391.8605404588683, 757.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
503.0, 1298.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 459.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
509.6757550823528, 757.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 463.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.7357903214241, 481.5176759252579

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
853.0, 474.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.6855844440493, 1293.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.25252468639036, 399.3765197575757

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 407.65685424949237

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 402.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.6597163188769, 575.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.0, 640.3469514304013

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.8570923587829, 395.0596407579074

c265

c265

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
633.7609338857217, 529.0

c266

c266

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
770.0, 244.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.4924053533731, 294.60183632778796

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.1578907275322, 287.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.4246907579123, 1266.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
838.1286652959662, 372.8374620062851

c270

c270

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
685.0, 1531.0

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.6195427690252, 1241.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.5304467246995, 1242.0

c273

c273

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.55953824301963, 785.0

c274

c274

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
125.98408911443573, 783.0

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.0, 448.40437564964543

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 1501.0

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.0, 1495.0

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.6154120165562, 1506.4984801712583

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
904.9830171128224, 1256.5209969063105

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1093.1940215386403, 441.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.5777087639997, 1359.1554175279994

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.8, 460.4

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.24827974911, 1407.0378439591532

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.3854596355656, 1352.0

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.9383594873914, 1352.0

c285

c285

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
386.0, 796.0

c286

c286

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1065.0, 454.0

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.7504216358204, 467.98266599986107

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 473.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1085.0, 1000.6753833509902

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.895183587735, 265.0

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.6388542106463, 268.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.2814378793594, 270.0

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 590.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.1608177968205, 650.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.0, 655.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 726.0

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.5549596630023, 565.0

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.8828019791332, 567.0

c298

c298

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
677.0, 501.0

c299

c299

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1087.0, 835.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1126.0, 962.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 505.0

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.9698918137259, 572.0

c301

c301

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
857.0, 572.0

c302

c302

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.0, 434.9922778767137

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.2929730966948, 444.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.0, 504.0

c305

c305

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 559.0

c306

c306

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.3715705307978, 509.0

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.9488420383177, 553.0

c308

c308

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.9969577410128, 559.2206057307866

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
999.0, 813.0311850272968

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
735.5458827133112, 438.6570009553913

c310

c310

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
927.4777781351485, 578.9857202589105

c312

c312

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
597.0, 578.2832816071599

c314

c314

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.9904988089992, 816.0

c315

c315

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 819.0

c316

c316

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.9819726648159, 827.0

c317

c317

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
544.026804687348, 827.0

c318

c318

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
947.2271683851237, 344.6837309286769

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1141.0, 821.2876358420971

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 336.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.6135719910778, 426.0

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1049.0, 364.0

c322

c322

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.0, 347.0

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 351.0

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 361.0

c325

c325

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1069.7097557461818, 406.0

c326

c326

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1125.9792745494692, 406.0

c327

c327

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.4400399494056, 450.940375069825

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.92235181721475, 745.0

c329

c329

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.8942701561832, 914.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
738.9859714103242, 1233.0

c330

c330

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
811.1745744402788, 1239.0

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
741.7660801102196, 1235.0

c332

c332

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.83431613260046, 909.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
975.0, 1006.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.9551113054329, 1049.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.995328807718, 1047.2733445746228

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
915.0, 1193.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.3762366412628, 1247.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 899.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 823.9592936822179

c40

c40

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
936.9688730324436, 1131.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
943.8293106144645, 916.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.3513091273064, 1318.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.6994371546483, 1294.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.92197834399, 981.3786775784864

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.8047962662762, 1170.7564609992598

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
995.0, 916.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.541646695148, 916.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.8470183397434, 1178.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
986.0, 860.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.9411670204042, 957.9684350024883

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 983.5420127282403

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.0, 756.7868516768782

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.5457343024661, 757.9813641735678

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 682.8361755317706

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1147.0, 785.0

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1133.0, 183.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.1567780202915, 200.11617858220623

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.7705920107007, 194.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.9711576880164, 1380.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1098.0, 888.9711254108329

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.9751851892278, 1357.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.2039430457753, 265.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.0, 1210.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 1194.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.1984430354239, 1184.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 1413.8553499981772

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.0, 1440.8529642184483

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1470.1313708498985

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0, 722.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.0393508318149, 1142.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1149.0, 810.1183222219962

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
823.296093284079, 952.9945186701341

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.0, 1029.9382230137094

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.0297015069195, 265.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
832.3921212357765, 265.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 1423.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 1425.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.0, 1426.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.0, 1507.186723623442

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 1428.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.66387219255233, 1407.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1150.0, 814.7160615370822

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.85212521646727, 1438.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.95732606183725, 1468.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.99854221593355, 1503.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
214.0, 366.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.5961068211504, 359.52673997529934

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.0, 347.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.0, 137.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 190.75586766093727

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 183.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.9999973605616, 146.6493730805696

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1123.0, 824.5577758296878

c9

c9

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
912.8827051358348, 257.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.5727698518699, 151.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.0, 553.68253731564

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
134.0, 586.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.0, 543.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 615.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
191.0, 619.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
190.0, 546.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
127.0, 662.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
204.9952479948287, 703.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back