1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17934330.csml convertedTime:2009.07.01.11:08

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptor signal transduction.
Authors Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S.
Affiliation Department of Molecular Science and Technology, Ajou University, Suwon 443-749,Korea.
Abstract Toll-like receptors (TLRs) are the archetypal pattern recognition receptors insensing exogenous pathogens. Activation of TLRs is a first line of defense ofthe immune system, leading to the activation and recruitment of neutrophils andmacrophages to sites of infection and enhances antimicrobial activity. The TLRsignaling through different intracellular molecules, such as MAP kinases andIkappaB kinases which are conserved signaling elements for many receptors, leadsto a distinct set of proinflammatory gene expressions. However, how thesepathways differentially and precisely control the transcription of identicalgenes remains largely unknown. Our review focuses on the details of up-to-datesignaling molecules including negative regulators and their role in controllinginnate immune response. We also stress the importance of developing systemicapproaches for the global understanding of TLR signaling so that appropriatedrug therapeutic targets can be identified for regulating inflammatory diseases.
PMID 17934330
Model Abstract

Entity

G010214:c-fos G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010713:IRF-7 G011221:CCR7 G011345:IL10 G012252:CXCL10 G013255:TLR9 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000049:c-Jun MO000000058:NF-kappaB MO000000062:ATF-2 MO000000193:RelA-p65 MO000000212:TRAF6 MO000000248:IKK MO000000276:AP-1 MO000000279:c-Fos MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000007702:IRF-7 MO000007822:JNK1 MO000013119:STAT1 MO000016569:IRAK-M MO000016573:MyD88 MO000016608:IKK-i MO000016882:LPS MO000016903:JNK2 MO000017124:p56Dok-2 MO000017247:IL-10 MO000017265:IL-12 MO000017549:fibronectin MO000019331:TBK1 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000019479:protein remnants MO000019488:p62Dok-1 MO000019704:STAT1{p} MO000019967:CCR7 MO000020119:Hsp60 MO000021614:Hsp70 MO000022185:flagellin MO000022224:dsRNA MO000038365:ATF-2{p} MO000038589:c-Jun{p} MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000068831:MAL e1: e10: e100:ERK{active} e101:NF-kappaB e102:PKA e103:p38{p} e11:Fusion(F)protein : TLR4 e12:taxol e13:taxol:TLR4 e14:fibronectin:TLR4 e15:HSP60:TLR4 e16:HSP70:TLR4 e17:Hyaluronan:TLR4 e18:hyaluronan e19:TLR2:zymosan e2: e20:zymosan e21:TLR2:TLR6 e22:lipoproteins e23:lipoprotein:TLR2:TLR6 e24:flagellin:TLR5 e25:ssRNA:TLR7 e26:ssRNA e27:ssRNA:TLR8 e28:R848 e29:R848:TLR8 e3: e30:R848:TLR7 e31:CpG DNA e32:CpG DNA:TLR9 e33: e34: e35: e36:LPS:TLR4:MAL e37:LPS:TLR4:MAL:MYD88 e38:LPS:TLR4:MYD88:IRAK4 e39:LPS:TLR4:MAL:MYD88:IRAK4{p} e4: e40:IRAK1 e41:LPS:TLR4:MAL:MYD88:IRAK4{p}:IRAK1 e42:LPS:TLR4:MAL:MYD88:IRAK4{p}:IRAK1{p} e43:IRAK4{p}:IRAK1{p} e44:LPS:TLR4:MAL:MYD88 e45:TRAF6{p} e46:TRAF6[ub} e47:TAK1:TAB1:TAB2 e48:TRAF6{ub}:TAK1:TAB1:TAB2 e49:TRAF6{ub}:TAK1{active}:TAB1:TAB2 e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:fusion (F) protein e60: e61: e62: e63:IKK{active} e64:JNK{active} e65:p38{active} e66:AP-1{active} e67:e67 e68:LPS:TLR4:TRAM:TRIF e69:LPS:TLR4:TRAM:TRIF:IKK-i:TBK1 e7: e70:IRF-3{active} e71:IRF-7{active} e72:IFN-beta e73:dsRNA:TLR3:TRIF e74:IRAK4{p}:IRAK1{p}:TRAF6 e75:IkappaB-zeta e76:NF-kappaB:IkappaBzeta e77:JunB:JunD e78:JunB:JunD{active} e79:Ig light chain e8: e80:Ig light chain e81:JNK1{active} e82:JNK2{active} e83:IL-12 e84:PAM3CSK4 e85:TLR2:TLR6:PAM3CSK4 e86:PI3K{active} e87:IRF-3{active} e88:(IRF-3)2 e89:p50:p65 e9: e90:p50:p65{active} e91:IRF-3{p}:p65 e92:IFN-betaR e93:IFN-beta:IFN-betaR e94:IFN-alpha e95:IFN-alpha e96:MYD88{ub} e97:TGF-beta e98:MYD88s e99:NS3/4A

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98
Model Detail
714.0, 1410.0
28.0, 28.0

c-fos

--

G010214

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p67

p68

true true true true

csml-variable:Double

m93203

10

false

infinite

0

unit false false false
TRANSFACG010214

--

Go back
793.0, 1317.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p39 p40 p80 p84

p41 p42

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
778.0, 1530.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46

p47

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
963.0, 1343.0
34.0, 34.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p62

p63

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
833.0, 1561.0
30.0, 30.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87

p88

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
895.0, 1335.0
34.0, 34.0

CCR7

--

G011221

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p49

p50

true true true true

csml-variable:Double

m94106

10

false

infinite

0

unit false false false
TRANSFACG011221

--

Go back
935.0, 1219.0
34.0, 34.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p69

p70

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
659.0, 1243.0
26.0, 26.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p79 p83 p85

--

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
1035.0, 1371.0
26.0, 26.0

TLR9

--

G013255

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p97

p98

true true true true

csml-variable:Double

m95738

10

false

infinite

0

unit false false false
TRANSFACG013255

--

Go back
829.0, 877.0
30.0, 30.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1192.0, 1332.0
24.0, 24.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p55 p95

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1077.0, 1161.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1131.0, 527.0
34.0, 34.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
550.0, 1538.0
28.0, 28.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57 p58

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
963.0, 1383.0
26.0, 26.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

p45

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
735.0, 879.0
26.0, 26.0

ATF-2

--

MO000000062

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p60 p61

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
1127.0, 739.0
26.0, 26.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
1273.0, 1221.0
38.0, 38.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false

--

Go back
962.0, 1022.0
36.0, 36.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1079.0, 1539.0
34.0, 34.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p33

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
400.0, 1416.0
32.0, 32.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68

--

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
1482.0, 1546.0
36.0, 36.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
893.0, 1629.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
930.0, 474.0
36.0, 36.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p75

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1055.0, 371.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

p38

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
389.0, 653.0
30.0, 30.0

JNK1

--

MO000007822

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m997

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007822

--

Go back
1173.0, 1629.0
30.0, 30.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1124.0, 1376.0
32.0, 32.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
1177.0, 721.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p90

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
817.0, 325.0
30.0, 30.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1574.0, 258.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
477.0, 881.0
30.0, 30.0

JNK2

--

MO000016903

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m1818

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
842.0, 722.0
28.0, 28.0

p56Dok-2

--

MO000017124

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m2006

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000017124

--

Go back
151.0, 1123.0
34.0, 34.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
979.0, 1655.0
34.0, 34.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64 p72

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1697.0, 457.0
30.0, 30.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
891.0, 335.0
26.0, 26.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1327.0, 251.0
42.0, 42.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3 p4 p5 p6 p7

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1235.0, 231.0
34.0, 34.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
716.0, 500.0
31.0, 31.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1017.0, 221.0
38.0, 38.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1186.0, 230.0
36.0, 36.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
1249.0, 445.0
22.0, 22.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91 p92

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
776.0, 800.0
32.0, 32.0

p62Dok-1

--

MO000019488

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93

true true true true

csml-variable:Double

m4043

10

false

infinite

0

unit false false false
InterProIPR002404
TRANSPATHMO000019488

--

Go back
1158.0, 1702.0
28.0, 28.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p96

--

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
389.0, 1337.0
30.0, 30.0

CCR7

--

MO000019967

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50

--

true true true true

csml-variable:Double

m4495

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019967

--

Go back
1665.0, 529.0
38.0, 38.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
1620.0, 632.0
24.0, 24.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
1019.0, 71.0
34.0, 34.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
763.0, 443.0
34.0, 34.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
650.0, 990.0
20.0, 20.0

ATF-2{p}

--

MO000038365

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p60 p61

--

true true true true

csml-variable:Double

m16575

10

false

infinite

0

unit false false false
TRANSPATHMO000038365

--

Go back
483.0, 1659.0
26.0, 26.0

c-Jun{p}

--

MO000038589

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p57 p58

--

true true true true

csml-variable:Double

m16780

10

false

infinite

0

unit false false false
TRANSPATHMO000038589

--

Go back
1209.0, 825.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
923.0, 283.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p43 p92

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1187.0, 315.0
34.0, 34.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
741.0, 541.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

p43 p76 p77

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
557.0, 685.0
38.0, 38.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p14

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
672.0, 464.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

p98

p16

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
587.0, 451.0
34.0, 34.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p15

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1252.0, 624.0
32.0, 32.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
273.75, 197.9969080091176
1115.8234892608616, 1620.1757064067688

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
469.0, 240.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
825.0, 1005.0
30.0, 30.0

ERK{active}

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
775.0, 1043.0
26.0, 26.0

NF-kappaB

--

e101

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p94

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1271.0, 1303.4599999999998
34.720000000000006, 26.039999999999992

PKA

--

e102

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p95

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1255.0, 1474.0731707317073
33.65853658536585, 26.92682926829268

p38{p}

--

e103

cso30:c:Protein

cso30:i:CC_Extracellular

--

p95

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1329.5, 379.92983994738
20.70291602718702, 40.07016005262004

Fusion(F)protein : TLR4

--

e11

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1617.0, 404.6602186711523
53.5407905803196, 30.339781328847774

taxol

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1343.5, 436.14207410655564
24.726595044946286, 47.85792589344443

taxol:TLR4

--

e13

cso30:c:Complex

cso30:i:CC_Extracellular

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1343.5, 495.3922385441789
25.114010085507562, 48.607761455821084

fibronectin:TLR4

--

e14

cso30:c:Complex

cso30:i:CC_Extracellular

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1342.5, 554.4979171234379
26.092742819557113, 50.50208287656216

HSP60:TLR4

--

e15

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p5

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1345.5, 622.89081341811
21.7564130673098, 42.10918658188993

HSP70:TLR4

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1343.5, 683.8528831396623
25.39267704450778, 49.14711686033765

Hyaluronan:TLR4

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1648.0, 694.1631623212783
47.35912531539109, 26.836837678721615

hyaluronan

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1284.5, 216.7075202806402
23.91778118833589, 46.29247971935979

TLR2:zymosan

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
273.75, 197.9969080091176
1115.8234892608616, 1620.1757064067688

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1189.0, 32.71740958788897
53.4398654331371, 30.28259041211102

zymosan

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1134.5, 227.38543576070657
26.635227462089656, 32.61456423929346

TLR2:TLR6

--

e21

cso30:c:Complex

cso30:i:CC_Extracellular

--

p9

p10 p66

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1090.0, 107.8760984182777
36.34446397188049, 23.623901581722322

lipoproteins

--

e22

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1085.5, 216.2936318590567
28.45623050100937, 39.706368140943304

lipoprotein:TLR2:TLR6

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
971.5, 215.87919315939487
25.37908353431265, 49.12080684060513

flagellin:TLR5

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
567.5, 623.8265731199299
25.406270554702914, 49.17342688007017

ssRNA:TLR7

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
443.0, 423.1829642622232
50.93619820214865, 26.317035737776802

ssRNA

--

e26

cso30:c:Rna

cso30:i:CC_Cytoplasm

--

--

p12 p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
558.5, 486.07717605788207
26.826792370094278, 51.922823942117965

ssRNA:TLR8

--

e27

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p13

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
496.0, 646.3195962994112
48.84777123633305, 27.680403700588727

R848

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p14 p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
559.5, 739.8528831396624
25.39267704450778, 49.14711686033764

R848:TLR8

--

e29

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p14

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
296.06646978521724, 220.31337779433483
1071.1905496904267, 1575.5427668363359

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
564.5, 558.101732076299
22.68077176057882, 43.89826792370094

R848:TLR7

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
659.0, 370.0035818519501
57.67577606792253, 12.49641814804988

CpG DNA

--

e31

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
635.5, 440.48410436307825
24.549879412409556, 47.51589563692173

CpG DNA:TLR9

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p53 p54 p55

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
566.0, 462.06481709745333
212.87573246354256, 355.3942313162533

--

e33

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false true false

--

Go back
566.0, 462.06481709745333
212.87573246354256, 355.3942313162533

--

e34

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false true false

--

Go back
566.0, 462.06481709745333
212.87573246354256, 355.3942313162533

--

e35

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false true false

--

Go back
1333.5, 747.3666727839972
29.837217838135437, 41.63332721600294

LPS:TLR4:MAL

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1330.0, 807.764705882353
28.94117647058824, 48.235294117647065

LPS:TLR4:MAL:MYD88

--

e37

cso30:c:Complex

cso30:i:CC_Extracellular

--

p19

p20

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1331.0, 869.2941176470588
26.823529411764707, 44.705882352941174

LPS:TLR4:MYD88:IRAK4

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1331.0, 930.7941176470589
25.32352941176471, 42.20588235294118

LPS:TLR4:MAL:MYD88:IRAK4{p}

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
337.3519388878692, 259.3671999184647
988.6196114851235, 1497.435122588075

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1253.0, 978.06
37.919999999999995, 28.439999999999998

IRAK1

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p22

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1331.0, 1014.5
25.5, 42.50000000000001

LPS:TLR4:MAL:MYD88:IRAK4{p}:IRAK1

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1330.0, 1072.7941176470586
28.323529411764703, 47.20588235294118

LPS:TLR4:MAL:MYD88:IRAK4{p}:IRAK1{p}

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p25

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1269.5, 1170.125979003499
29.297117147142142, 35.87402099650058

IRAK4{p}:IRAK1{p}

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24 p25

p44

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1328.5, 1142.3626353459351
31.273444668746553, 43.63736465406497

LPS:TLR4:MAL:MYD88

--

e44

cso30:c:Complex

cso30:i:CC_Extracellular

--

p25

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1192.0, 1140.390243902439
39.512195121951216, 31.60975609756097

TRAF6{p}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p24

p26

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1185.0, 986.6550034989502
46.10216934919524, 35.344996501049685

TRAF6[ub}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1194.5, 860.4277849146633
27.643420811158016, 38.57221508533676

TAK1:TAB1:TAB2

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p27

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1119.0, 922.9411764705878
25.23529411764706, 42.058823529411775

TRAF6{ub}:TAK1:TAB1:TAB2

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1041.0, 1001.205882352941
22.676470588235293, 37.794117647058826

TRAF6{ub}:TAK1{active}:TAB1:TAB2

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29 p30 p31

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1327.5, 307.06336329752247
25.283928962946717, 48.936636702477514

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p1

p18 p34 p48 p93 p97 p98

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
592.0, 1140.4647618250249
519.1683931513986, 470.8286917406547

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
648.0740536364638, 1151.6227173420239
303.5733248594771, 456.32678131743114

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
598.7675581975043, 1146.7489230084216
505.6332767563904, 458.26036937386067

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
599.7343522257191, 1147.7157170366363
503.6996886999603, 456.32678131743114

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
592.0, 1140.4647618250249
519.1683931513986, 470.8286917406547

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
592.0, 1140.4647618250249
519.1683931513986, 470.8286917406547

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
599.7343522257191, 1147.7157170366363
503.6996886999603, 456.32678131743114

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
970.9832590602387, 1333.8235674680038
32.434788631248196, 29.362019181972105

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
885.905384577328, 1469.1747314180896
91.84543268041499, 83.14428642648114

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
592.0, 1140.4647618250249
519.1683931513986, 470.8286917406547

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1627.0, 322.6766955121755
41.875628899174885, 25.82330448782451

fusion (F) protein

--

e6

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
714.365069106304, 1349.6971419450638
16.441300173282492, 7.916181564913807

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
713.8160475550767, 1326.0892152422848
56.27470900081038, 101.29447620145878

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
737.4239742578561, 1391.9718013895754
8.784344819638685, 8.784344819638699

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1006.0, 1142.0
36.0, 36.0

IKK{active}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p81 p94

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1109.0, 1277.0
30.0, 30.0

JNK{active}

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p32

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1177.0, 1457.0
29.0, 29.0

p38{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p55

p33 p58 p61 p62 p63 p64 p65 p96

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1099.0, 1652.0
29.0, 29.0

AP-1{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p33

--

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
916.5, 217.87814277849156
31.620664342081117, 44.12185722150853

e67

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
861.0, 216.91176470588232
22.852941176470587, 38.08823529411765

LPS:TLR4:TRAM:TRIF

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p35

p37

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
798.0, 216.2352941176472
28.058823529411764, 46.76470588235295

LPS:TLR4:TRAM:TRIF:IKK-i:TBK1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p36 p38

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
267.0, 192.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
970.0, 622.0
36.0, 36.0

IRF-3{active}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p75

p39 p41 p77 p82

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1079.0, 531.0
34.0, 34.0

IRF-7{active}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p40 p42 p89

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
213.0, 1231.7318373918292
38.5429663916281, 23.76816260817066

IFN-beta

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41 p42

p86

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
763.5, 586.7861993026244
25.236557166452556, 35.21380069737567

dsRNA:TLR3:TRIF

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1224.5, 1322.6158928243717
31.091943475867136, 43.384107175628564

IRAK4{p}:IRAK1{p}:TRAF6

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p24

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
834.0, 1404.127416520211
35.95782073813709, 23.372583479789103

IkappaB-zeta

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
883.5, 1464.53624395934
24.675554074320946, 30.214964172637888

NF-kappaB:IkappaBzeta

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
570.5, 906.8656890518246
27.876353941009835, 34.13431094817531

JunB:JunD

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
520.5, 1034.6245625729046
22.35660723212798, 27.37543742709549

JunB:JunD{active}

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p49 p50 p51 p52

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
671.0, 1502.840830449827
49.048442906574394, 26.15916955017301

Ig light chain

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51

p52

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
270.0, 213.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
380.0, 1501.14
40.48, 30.36

Ig light chain

--

e80

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p52

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
414.0, 794.0
35.0, 35.0

JNK1{active}

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p57 p60

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000007822

--

Go back
385.0, 977.0
30.0, 30.0

JNK2{active}

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p56 p59

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
946.0, 1476.0
60.0, 32.0

IL-12

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65 p71

p64 p72

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
737.0, 32.873843566021876
54.92851135407906, 31.126156433978135

PAM3CSK4

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p66

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
733.5, 215.2235272527069
29.939805468893383, 41.776472747293084

TLR2:TLR6:PAM3CSK4

--

e85

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

p67 p68 p69 p70 p71 p72

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1103.0, 651.0
34.0, 34.0

PI3K{active}

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p75

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
842.0, 1202.0
36.0, 36.0

IRF-3{active}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77

p78

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
844.5, 1297.9148475254121
23.752874520913178, 29.085152474587563

(IRF-3)2

--

e88

cso30:c:Complex

cso30:i:CC_Extracellular

--

p78

p79 p80

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
652.5, 1633.8546908848525
22.98533577737043, 28.145309115147466

p50:p65

--

e89

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p81

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
290.0, 233.0
1043.9860777283795, 1502.848888244384

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
752.5, 1677.8546908848525
22.98533577737043, 28.145309115147466

p50:p65{active}

--

e90

cso30:c:Complex

cso30:i:CC_Extracellular

--

p81

p85

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1057.0, 758.9116022099448
30.679558011049725, 34.08839779005525

IRF-3{p}:p65

--

e91

cso30:c:Complex

cso30:i:CC_Extracellular

--

p82

p83 p84

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
300.5, 1288.0755711775043
30.500878734622145, 46.92442882249561

IFN-betaR

--

e92

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p86

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
302.5, 1358.0771760578823
26.826792370094278, 51.92282394211796

IFN-beta:IFN-betaR

--

e93

cso30:c:Complex

cso30:i:CC_Extracellular

--

p86

p87 p88

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1103.0, 321.7847655463877
33.59227208693902, 20.715234453612396

IFN-alpha

--

e94

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p89

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1151.0, 437.7847655463877
33.59227208693902, 20.715234453612396

IFN-alpha

--

e95

cso30:c:Protein

cso30:i:CC_Extracellular

--

p89

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1178.0, 583.7312806158153
43.39398180545837, 33.26871938418474

MYD88{ub}

--

e96

cso30:c:Protein

cso30:i:CC_Extracellular

--

p90

p91

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1478.0, 786.2609841827768
43.44463971880492, 28.239015817223205

TGF-beta

--

e97

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p63 p90 p91 p94

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1085.5, 826.0915677198632
21.526866572751054, 34.90843228013685

MYD88s

--

e98

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20 p22 p23

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
533.0, 291.3657623947614
21.074836295603365, 48.63423760523854

NS3/4A

--

e99

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p92

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1440.0, 260.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000016882

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
1098.0, 154.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 17934330, 11095740 TLR6 associates with TLR2 and recognizes lipoproteins from mycoplasma.

Go back
1026.0, 141.5
20.5, 20.5

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022185 MO000019399

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 17934330, 11323673 TLR5 mediates the induction of the immune response by bacterial flagellins.

Go back
520.0, 424.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000042126

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m26*m19940*0.1

nodelay

--

true

0

false

PMID: 17934330, 11130078, 14976262, 14976261 Recent studies showed that ssRNA is the natural ligand for TLR7/8.

Go back
512.0, 492.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000042007 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m19823*m26*0.1

nodelay

--

true

0

false

PMID: 17934330, 11130078, 14976262, 14976261 Recent studies showed that ssRNA is the natural ligand for TLR7/8.

Go back
508.0, 691.5
24.5, 24.5

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m19823*m28*0.1

nodelay

--

true

0

false

PMID: 17934330, 11812998, 12032557, 10346978 A synthetic compound (imidazoquinoline compound R848) with antiviral activity has been described as a ligand for TLR7 and TLR8.

Go back
504.0, 568.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000042126

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m28*m19940*0.1

nodelay

--

true

0

false

PMID: 17934330, 11812998, 12032557, 10346978 A synthetic compound (imidazoquinoline compound R848) with antiviral activity has been described as a ligand for TLR7 and TLR8.

Go back
678.0, 414.0
19.0, 19.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m19828*m31*0.1

nodelay

--

true

0

false

PMID:17934330, 11130078 TLR9 has been shown to recognize unmethylated bacterial CpG DNA.

Go back
773.0, 505.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17934330, 11607032 TLR3 recognizes double stranded RNA.

Go back
1276.0, 728.0
16.0, 16.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e5

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c53 : 1

m43675*m5*0.1

nodelay

--

true

0

false

PMID: 17934330 The primary function of MAL in TLR signaling seems to control the recruitment of MyD88 to TLR4.

Go back
1265.0, 785.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m1572*m36*0.1

nodelay

--

true

0

false

PMID: 17934330 MyD88 binds with the TIR domain of the receptor and phosphorylates IRAK4 which in turn phosphorylates IRAK1.

Go back
1441.0, 325.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3961*m6*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
1265.0, 877.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000039077 e98

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c253 : 1
stoichiometry:c60 : 1

m37*m17258*0.1

nodelay

--

true

0

false

PMID: 17934330 MyD88 binds with the TIR domain of the receptor and phosphorylates IRAK4 which in turn phosphorylates IRAK1. PMID: 17934330 MyD88s does not interact with IRAK4 because it lacks a region that is important for IRAK4 recruitment. So, IRAK4 is not recruited to the IL-1R, thereby preventing the association of IRAK1 and IRAK4 and thus the phosphorylation of IRAK1.

Go back
1420.0, 916.0
23.0, 23.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 17934330 MyD88 binds with the TIR domain of the receptor and phosphorylates IRAK4 which in turn phosphorylates IRAK1.

Go back
1413.0, 980.5
22.5, 22.5

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 e40 e98

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c254 : 1
stoichiometry:c65 : 1

m39*m40*0.1

nodelay

--

true

0

false

PMID: 17934330 MyD88s does not interact with IRAK4 because it lacks a region that is important for IRAK4 recruitment. So, IRAK4 is not recruited to the IL-1R, thereby preventing the association of IRAK1 and IRAK4 and thus the phosphorylation of IRAK1.

Go back
1409.0, 1057.0
21.0, 21.0

p23

p23

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e41 e98

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c255 : 1
stoichiometry:c67 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17934330 IRAK1 undergoes autophosphorylation. PMID: 17934330 MyD88s does not interact with IRAK4 because it lacks a region that is important for IRAK4 recruitment. So, IRAK4 is not recruited to the IL-1R, thereby preventing the association of IRAK1 and IRAK4 and thus the phosphorylation of IRAK1.

Go back
1202.0, 1206.0
19.0, 19.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e74

e45 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c72 : 1
stoichiometry:c127 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 17934330 IRAK1 phosphorylates TRAF6 leading to the ubiquitination of TAK complex.

Go back
1248.0, 1120.0
23.0, 23.0

p25

p25

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e42

e43 e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17934330 Upon stimulation, IRAK4 and IRAK1 are sequentially phosphorylated and dissociated from MyD88, which results in activation of TRAF6.

Go back
1196.0, 1076.0
23.0, 23.0

p26

p26

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17934330, 15125833 TRAF6 is ubiquitinated at K63 chains and this K63 polyubiquitinated TRAF6 mediates activation of the next component in the pathway, which is most likely to be TGF-¦Â activated kinase-1 (TAK1)

Go back
1197.0, 933.0
21.0, 21.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m46*m47*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1042.0, 934.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1014.0, 1086.0
19.0, 19.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m207*m49*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1457.0, 409.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3961*m12*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
1142.0, 1226.0
19.0, 19.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m64*m49*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1174.0, 1410.5
19.5, 19.5

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000022 e49

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m66*m49*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1138.0, 1594.0
19.0, 19.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000276 e64

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m219*m65*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1090.0, 1610.5
19.5, 19.5

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000276 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m219*m67*0.1

nodelay

--

true

0

false

PMID: 17934330 TAK1-TAB complex associates with K63-ubiquitinated TRAF6 to activate TAK1 kinase, which then activates the IKK complex as well as the JNK kinases.

Go back
1264.0, 320.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000041132

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m5*m19005*0.1

nodelay

--

true

0

false

PMID: 17934330 The role of TRAM in LPS signaling appears to act as a bridging adapter connecting TLR4 and TRIF.

Go back
860.0, 284.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000041125

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m69*m18998*0.1

nodelay

--

true

0

false

PMID: 17934330 The role of TRAM in LPS signaling appears to act as a bridging adapter connecting TLR4 and TRIF.

Go back
1019.0, 559.0
17.0, 17.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m977*m71*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
790.0, 290.0
19.0, 19.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000016608 MO000019331

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m70*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
1103.0, 455.0
17.0, 17.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e69

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c111 : 1
stoichiometry:c110 : 1

m980*m71*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
801.0, 1213.0
21.0, 21.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e70

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
1549.0, 460.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000017549

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3961*m2341*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
767.0, 1231.0
17.0, 17.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e71

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
549.0, 1233.0
21.0, 21.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c120 : 1
stoichiometry:c117 : 1

m93217*m72*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
471.0, 1271.0
17.0, 17.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m93217*m73*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Two noncanonical I¦ÊB kinases (IKKs), TBK1 (TANK-binding kinase 1) and IKK¦Å (I¦ÊB kinase ¦Å), interact with TRIF, activate IRF3/IRF7 and finally lead to IFN-¦Â production.

Go back
802.0, 546.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17934330 TRIF is an adapter for TLR3 and TLR4, and is associated with the MyD88-independent cascade.

Go back
1231.0, 1231.0
17.0, 17.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000000212 MO000016569

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c259 : 1
stoichiometry:c71 : 1

m43*m183*0.1

nodelay

--

true

0

false

PMID: 17934330, 12140561 IRAK1 has three TRAF6 (tumor necrosis factor receptorassociated factor 6) binding motifs to mediate the interaction with TRAF6. PMID: 17934330, 12150927 TRAF6 and IRAK association is prevented by IRAKM.

Go back
906.0, 1402.5
19.5, 19.5

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e75 MO000000058

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m78*m77*0.1

nodelay

--

true

0

false

PMID: 17934330, 15618216, 15522867 IkB¦Æ to interact with NF-¦ÊB via a C terminal ankyrin repeat domain in the nucleus to induce IL-6.

Go back
780.0, 1468.0
23.0, 23.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e76

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 17934330, 15618216, 15522867 IkB¦Æ to interact with NF-¦ÊB via a C terminal ankyrin repeat domain in the nucleus to induce IL-6.

Go back
783.0, 1634.5
18.5, 18.5

p47

p47

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 17934330, 15618216, 15522867 IkB¦Æ to interact with NF-¦ÊB via a C terminal ankyrin repeat domain in the nucleus to induce IL-6.

Go back
573.0, 957.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m5*m80*0.1

nodelay

--

true

0

false

PMID: 17934330, 15226448 LPS stimulation in precursor B cells and primary dendritic cells leads to JUND and JUNB activation.

Go back
902.0, 1297.5
20.5, 20.5

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e78

G011221

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 17934330, 15226448 JunB and JunD complex in turn are required for high-level sustained induction of chemokine receptor 7 (CCR-7) and Ig light chain expression and production of surface IgM.

Go back
1465.0, 537.5
21.5, 21.5

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000020119

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3961*m4645*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
523.0, 1343.0
17.0, 17.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011221 e78

MO000019967

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m94106*m81*0.1

nodelay

--

true

0

false

PMID: 17934330, 15226448 JunB and JunD complex in turn are required for high-level sustained induction of chemokine receptor 7 (CCR-7) and Ig light chain expression and production of surface IgM.

Go back
686.0, 1374.0
19.0, 19.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 17934330, 15226448 JunB and JunD complex in turn are required for high-level sustained induction of chemokine receptor 7 (CCR-7) and Ig light chain expression and production of surface IgM.

Go back
487.0, 1507.0
17.0, 17.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e79 e78

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m82*m81*0.1

nodelay

--

true

0

false

PMID: 17934330, 15226448 JunB and JunD complex in turn are required for high-level sustained induction of chemokine receptor 7 (CCR-7) and Ig light chain expression and production of surface IgM.

Go back
422.0, 738.0
19.0, 19.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000007822 e32

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m997*m32*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
421.0, 921.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016903 e32

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c153 : 1
stoichiometry:c152 : 1

m1818*m32*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
1236.0, 1408.0
15.0, 15.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e32

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m66*m32*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
487.0, 1598.5
18.5, 18.5

p56

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000049 e82

MO000038589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m86*m85*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
539.0, 1610.5
18.5, 18.5

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000049 e81

MO000038589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m86*m84*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
595.0, 1603.0
17.0, 17.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000049 e65

MO000038589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m86*m67*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
670.0, 926.0
19.0, 19.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000062 e82

MO000038365

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c172 : 1
stoichiometry:c167 : 1

m87*m85*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
1454.0, 634.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000021614

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m3961*m5956*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
716.0, 948.0
15.0, 15.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000062 e81

MO000038365

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c173 : 1
stoichiometry:c169 : 1

m87*m84*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
751.0, 963.0
17.0, 17.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000062 e65

MO000038365

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c174 : 1
stoichiometry:c171 : 1

m87*m67*0.1

nodelay

--

true

0

false

PMID: 17934330, 9799232 CpG-DNA induces activation of JNK1/2 and p38 in murine macrophages and dendritic cells leading to the phosphorylation of c-JUN and ATF2.

Go back
969.0, 1285.0
21.0, 21.0

p62

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17934330 This activation via p38 is necessary for the full induction of TNF-¦Á and IL-12 as inhibition of p38 abrogates this biological response.

Go back
1184.0, 1552.0
23.0, 23.0

p63

p63

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010329 e65 e97

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c179 : 1
stoichiometry:c269 : 1
stoichiometry:c178 : 1

m93309*m67*0.1

nodelay

--

true

0

false

PMID: 17934330 This activation via p38 is necessary for the full induction of TNF-¦Á and IL-12 as inhibition of p38 abrogates this biological response. PMID: 17934330 TGF-¦Â potently inhibited LPS-induced NF-¦ÊB activation and TNF-¦Á release from RAW 264.7 cells but had no effect on IFN-¦Â promoter activation.

Go back
1018.0, 1578.0
19.0, 19.0

p64

p64

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e83 e65

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c180 : 1

m88*m67*0.1

nodelay

--

true

0

false

PMID: 17934330 This activation via p38 is necessary for the full induction of TNF-¦Á and IL-12 as inhibition of p38 abrogates this biological response.

Go back
1025.0, 1453.0
21.0, 21.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e65

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c181 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17934330 This activation via p38 is necessary for the full induction of TNF-¦Á and IL-12 as inhibition of p38 abrogates this biological response.

Go back
870.0, 75.5
17.5, 17.5

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m21*m89*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
748.0, 1368.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e85

G010214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c188 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
546.0, 1422.0
19.0, 19.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010214 e85

MO000000279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c189 : 1

m93203*m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
986.0, 1206.0
20.0, 20.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e85

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c193 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
1523.0, 698.5
18.5, 18.5

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000019394

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c19 : 1

m18*m3961*0.1

nodelay

--

true

0

false

PMID: 17934330, 10644670, 11062499, 11150311, 10623794, 11777948, 17400552 TLR4 recognizes not only LPS but also taxol, fusion (F) protein of respiratory syncytial virus, extra domain A of fibronectin, heat shock protein (HSP) 60, HSP 70 and hyaluronan.

Go back
689.0, 1129.0
21.0, 21.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e85

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c194 : 1

m94230*m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
955.0, 1427.0
17.0, 17.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e85

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c198 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
969.0, 1593.0
21.0, 21.0

p72

p72

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e83 e85

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c200 : 1

m88*m90*0.1

nodelay

--

true

0

false

PMID: 17934330, 15067049 TLR2 stimulation by PAM3CSK4 in DCs leads to the enhanced induction of c-FOS and induces high production of IL-10 but low level of IL-12.

Go back
978.0, 570.0
19.0, 19.0

p75

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e86

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c214 : 1
stoichiometry:c210 : 1

m977*m92*0.1

nodelay

--

true

0

false

PMID: 17934330, 15502848 Phosphatidylinositol 3-kinase has also been implicate in IRF3 activation and seems to be required for full activation of IRF3 following TLR3 signaling.

Go back
1121.0, 613.0
21.0, 21.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 MO000041446

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m91*m19314*0.1

nodelay

--

true

0

false

PMID: 17934330, 15502848 Phosphatidylinositol 3-kinase has also been implicate in IRF3 activation and seems to be required for full activation of IRF3 following TLR3 signaling.

Go back
1012.0, 812.0
23.0, 23.0

p77

p77

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e70 MO000041446

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c217 : 1
stoichiometry:c216 : 1

m72*m19314*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Stimulation via TLR3 leads to the nuclear localization of IRF3 which binds as a dimer to induce IP-10 and IFN-¦Â genes.

Go back
846.0, 1262.0
19.0, 19.0

p78

p78

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Stimulation via TLR3 leads to the nuclear localization of IRF3 which binds as a dimer to induce IP-10 and IFN-¦Â genes.

Go back
724.0, 1204.0
23.0, 23.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e88

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Stimulation via TLR3 leads to the nuclear localization of IRF3 which binds as a dimer to induce IP-10 and IFN-¦Â genes.

Go back
1285.0, 153.0
21.0, 21.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000019397

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m20*m3964*0.1

nodelay

--

true

0

false

PMID: 17934330, 10549626, 10623793, 10548109, 10588727 TLR2 responds to mycobacteria, yeast cell wall component zymosan, and Gram-positive bacteria.

Go back
801.0, 1413.0
21.0, 21.0

p80

p80

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e88

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17934330, 12692549 Stimulation via TLR3 leads to the nuclear localization of IRF3 which binds as a dimer to induce IP-10 and IFN-¦Â genes.

Go back
717.0, 1637.0
21.0, 21.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e89 e63

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c226 : 1
stoichiometry:c225 : 1

m95*m63*0.1

nodelay

--

true

0

false

PMID: 17934330, 9346241 IKK activated by TLR4 signaling activates the p65/p50 dimer.

Go back
1049.0, 677.0
21.0, 21.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000193 e70

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c203 : 1
stoichiometry:c229 : 1

m166*m72*0.1

nodelay

--

true

0

false

PMID: 17934330, 14557267 IRF3 activated by TBK1 forms dimer with p65 to induce IP-10 and IFN-¦Â.

Go back
740.0, 1284.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e91

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c230 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 17934330, 14557267 IRF3 activated by TBK1 forms dimer with p65 to induce IP-10 and IFN-¦Â.

Go back
757.0, 1429.0
21.0, 21.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e91

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c232 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 17934330, 14557267 IRF3 activated by TBK1 forms dimer with p65 to induce IP-10 and IFN-¦Â.

Go back
632.0, 1383.5
24.5, 24.5

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e90

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c234 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 17934330, 15315758 IP-10 and proinflammatory cytokines can be induced by p65/p50 dimers.

Go back
225.0, 1301.0
21.0, 21.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e72 e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m74*m98*0.1

nodelay

--

true

0

false

PMID: 17934330, 9786932, 9822609 Studies of IFN regulation also suggest that the autocrine/paracrine action of INF-¦Â produced by IRF3 can induce IRF7 de novo which activates IFN-¦Á.

Go back
836.0, 1500.0
23.0, 23.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e93

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c239 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 17934330, 9786932, 9822609 Studies of IFN regulation also suggest that the autocrine/paracrine action of INF-¦Â produced by IRF3 can induce IRF7 de novo which activates IFN-¦Á.

Go back
834.0, 1674.0
19.0, 19.0

p88

p88

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010713 e93

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1

m93631*m99*0.1

nodelay

--

true

0

false

PMID: 17934330, 9786932, 9822609 Studies of IFN regulation also suggest that the autocrine/paracrine action of INF-¦Â produced by IRF3 can induce IRF7 de novo which activates IFN-¦Á.

Go back
1146.0, 370.0
19.0, 19.0

p89

p89

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e94 e71

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c204 : 1
stoichiometry:c245 : 1

m100*m73*0.1

nodelay

--

true

0

false

PMID: 17934330, 9786932, 9822609 Studies of IFN regulation also suggest that the autocrine/paracrine action of INF-¦Â produced by IRF3 can induce IRF7 de novo which activates IFN-¦Á.

Go back
1193.0, 157.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019422 MO000019397

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m3987*m3964*0.1

nodelay

--

true

0

false

PMID: 17934330, 11095740 TLR6 associates with TLR2 and recognizes lipoproteins from mycoplasma.

Go back
1190.0, 654.0
20.0, 20.0

p90

p90

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016573 e97

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c249 : 1
stoichiometry:c248 : 1

m1572*m103*0.1

nodelay

--

true

0

false

PMID: 17934330, 15623538 TGF-¦Â facilitates ubiquitination and proteasomal degradation of MyD88 and attenuates MyD88-dependent signaling by decreasing cellular levels of MyD88 protein.

Go back
1206.0, 518.0
19.0, 19.0

p91

p91

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Extracellular

--

e96 e97

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1

m102*m103*0.1

nodelay

--

true

0

false

PMID: 17934330, 15623538 TGF-¦Â facilitates ubiquitination and proteasomal degradation of MyD88 and attenuates MyD88-dependent signaling by decreasing cellular levels of MyD88 protein.

Go back
987.0, 325.5
18.5, 18.5

p92

p92

cso30:i:ME_ProteinCleavage

cso30:i:CC_Extracellular

--

MO000041125 e99

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c258 : 1
stoichiometry:c257 : 1

m18998*m105*0.1

nodelay

--

true

0

false

PMID: 17934330, 15710891 The hepatitis C virus protein NS3/4A causes specific proteolysis of TRIF, an adaptor protein linking TLR3 to kinases responsible for activating transcription factors controlling a multiplicity of antiviral defenses.

Go back
803.0, 943.5
17.5, 17.5

p93

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000011 e5 MO000019488 MO000017124

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c261 : 1

m106*m5*0.1

nodelay

--

true

0

false

PMID: 17934330, 15699069 LPS induced ERK activation is prevented by the inhibitory adapter DOK1 (downstream of kinase 1) and DOK2.

Go back
807.0, 1099.0
17.0, 17.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e101 e63 e97

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1
stoichiometry:c266 : 1

m108*m63*0.1

nodelay

--

true

0

false

PMID: 17934330 TGF-¦Â potently inhibited LPS-induced NF-¦ÊB activation and TNF-¦Á release from RAW 264.7 cells but had no effect on IFN-¦Â promoter activation.

Go back
1252.0, 1396.0
23.0, 23.0

p95

p95

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000000022 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c272 : 1
stoichiometry:c271 : 1

m66*m109*0.1

nodelay

--

true

0

false

PMID: 17934330, 16125054 PKA phosphorylates p38 with a delayed kinetics forming the crosstalk point between G protein coupled receptors and TLRs.

Go back
1233.0, 1665.0
21.0, 21.0

p96

p96

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000013119 e65

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c275 : 1
stoichiometry:c274 : 1

m1357*m67*0.1

nodelay

--

true

0

false

PMID: 17934330, 12811837 p38 phosphorylate STAT1 forming another crosstalk with IFN signaling pathways.

Go back
1029.0, 1305.0
21.0, 21.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e5

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c276 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 17934330, 11947920 When stimulated with TLR4 ligand LPS, macrophages increase TLR9, and thus respond to CpG DNA more effectively.

Go back
726.0, 1082.0
19.0, 19.0

p98

p98

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G013255 e5

MO000042012

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c280 : 1
stoichiometry:c279 : 1

m95738*m5*0.1

nodelay

--

true

0

false

PMID: 17934330, 11947920 When stimulated with TLR4 ligand LPS, macrophages increase TLR9, and thus respond to CpG DNA more effectively.

Go back
1369.0, 272.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1369.0, 292.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 296.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 263.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.991972499923, 246.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0447410007557, 315.2089120009301

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.2584848522703, 307.36368810227157

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 270.8662560398757

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.0, 509.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.9364580533432, 576.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 261.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1081.0, 405.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1580.0, 472.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.4662594289339, 472.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
826.0, 250.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.3177616249826, 658.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.2889679298512, 1234.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.3579955141698, 565.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 1248.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.5407960788599, 1250.6714030952014

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1244.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
495.89871540896456, 1282.2689739509483

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.91594094580466, 1248.1566671701632

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1376.7907296779345, 475.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.6219328844392, 658.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.1504153958606, 565.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.0, 556.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.4430163941513, 309.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.7053735814004, 565.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1253.1675379317294, 1205.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 1240.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.0, 1196.892222835927

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.0, 1413.4437601569803

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.7229071442262, 1400.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1358.0, 293.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.1503917425116, 1422.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 1491.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.0, 1480.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.0, 1558.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.0, 1644.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 941.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.3557680678887, 978.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.1238306090648, 343.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 1318.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 1055.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1495.0, 548.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 1352.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.0, 1352.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
532.0, 1062.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
696.0, 1393.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 1062.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0, 1516.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
428.0, 1516.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.6094596386179, 1062.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
409.0, 683.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 757.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1376.7218109753596, 551.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
444.8394139733296, 480.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
448.85994340570034, 905.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.81673490323385, 942.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.35459257853086, 488.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1211.0, 1356.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.3900308614855, 1423.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.0, 483.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.1916583936265, 1564.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 1617.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 1007.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1375.0, 644.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.8996247238159, 1566.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.6568542494924, 1629.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
434.0, 829.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.0, 1566.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.9855816161192, 1617.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.784072775855, 1476.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.7008847747089, 900.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.3765324210899, 945.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.7898696961713, 905.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.567241614284, 961.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1355.0, 293.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
750.0, 905.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.6957666086846, 974.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 939.5689290811055

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.0, 820.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.2292894093006, 986.0542986607679

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
980.0, 1306.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.1430767088628, 1309.1247057036503

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
997.0, 1376.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1207.0, 1564.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.0, 1486.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1481.0, 644.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.8372338729644, 1597.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.2299027111483, 1469.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.0, 1508.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1053.9886031545104, 1464.4268719242868

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1043.5318615622855, 1483.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
894.8746343149539, 93.09138155586326

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 57.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.2302196956872, 93.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.7455923043988, 1391.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 1432.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1377.0, 708.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.9911861559956, 1425.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 257.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
559.2678904032907, 257.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.238549617608, 1220.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
193.0, 1140.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.4727404855597, 1146.8562474744806

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.0, 257.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.421432374055, 257.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
966.0, 1444.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 257.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1471.0, 272.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1550.0, 708.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.0, 1614.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1508.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 257.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 652.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.0, 396.529124941243

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
956.0, 510.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1357.0, 293.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 589.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.655668728355, 561.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1126.8323146698044, 634.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.0, 559.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1003.6467396888803, 590.4520614897217

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
992.0, 658.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0611859287433, 835.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.0, 571.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
857.6643638388299, 1238.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
856.0, 1281.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1296.0, 174.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.8132665336364, 1224.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.2593937564974, 1229.981966459253

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.9412711149687, 1327.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.3632612873492, 1354.9917483216825

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 1648.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 1658.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.1444311577056, 1178.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1076.2255823114385, 701.0241541460732

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 698.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.0, 63.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.1813408844941, 1266.5253855251153

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.2012859422737, 793.0

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.0, 1354.5129828169627

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.3285107301544, 793.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
646.0, 1276.8446454055274

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.994795814766, 1415.4183015595122

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
233.0, 1256.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0, 1312.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.0, 1321.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 1523.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1261.0, 181.07934577905587

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0, 1387.0

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
844.2889679298512, 1591.0

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.0, 412.8792665452907

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 1392.0

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1128.0, 343.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.0, 389.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1194.0, 681.9551113054329

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.0, 625.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1217.2912939643647, 672.2919648122692

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1204.0, 186.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.0, 544.8248474318787

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.7883546114383, 542.5222233649355

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1222.0, 473.8361755317706

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.0, 847.0

c253

c253

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1107.0, 849.0

c254

c254

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1107.0, 852.0

c255

c255

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
949.0, 304.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 339.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 316.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1151.0, 1251.3441916433483

c259

c259

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1214.1349527922714, 184.8485155621994

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.6544374799411, 907.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 961.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.1903574595053, 347.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0, 832.0

c263

c263

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
814.7883514900503, 750.0

c264

c264

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
795.0, 1069.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 1116.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.7661341493432, 1111.9201980039584

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
827.6483120270843, 810.0

c268

c268

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1202.4777333508048, 815.0

c269

c269

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1164.820821330685, 178.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1215.0, 1356.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1265.0, 1419.0

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1268.967504959058, 1329.0

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1203.0, 1653.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1193.000272339342, 1682.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1196.0, 1486.0

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1041.0, 1326.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.3379531030519, 356.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.8350425417933, 1105.472867487475

c278

c278

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.6260604238861, 503.9754653999402

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 132.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.9809008132552, 348.0

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1116.5777087639997, 180.15541752799933

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1360.0385665808597, 278.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1102.9240068653964, 173.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 105.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 170.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0615384615385, 162.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.0, 436.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 447.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.2829318197008, 444.31042355440945

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0045350063085, 522.7447943425558

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 450.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
535.0, 506.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1369.0, 285.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 704.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 674.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
531.0, 716.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.2907169448572, 598.9947159835715

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.9791383377085, 485.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 580.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 441.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 383.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.6568542494924, 433.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 477.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1470.0, 336.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.0, 516.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.4376015698018, 526.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1271.0, 656.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1292.0, 740.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.10751162133, 356.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1207.0, 747.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1293.4906334205523, 774.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1286.0, 801.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1292.1916583936265, 844.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1239.0, 854.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1356.9459451369958, 342.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.0, 889.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1358.0, 898.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1363.7012075212313, 931.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1356.0, 958.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1291.0, 992.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1363.9991456642429, 998.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1357.0, 1041.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1365.4966569186613, 1072.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1278.3660137653965, 1102.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1265.0, 1143.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1365.0, 293.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1271.0, 1136.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1240.0, 1248.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1212.0, 1180.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1215.676232709847, 1232.8224193126193

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1209.3897804297073, 1106.990498808999

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.0, 1030.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.0, 962.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.0, 899.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.0, 944.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1069.0, 944.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1486.0, 420.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1052.0, 953.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
994.0, 1058.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 1105.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.7210886532355, 1039.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1107.0, 1191.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.5777087639997, 1245.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1061.0, 1039.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1188.9734342450795, 1356.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.0, 1430.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.0, 1039.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1375.5281769940743, 424.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1113.0, 1572.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.79279858428, 1613.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.0, 1307.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.0, 1573.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 1630.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.1958192671552, 1486.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1295.0, 332.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.0, 332.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.7253979580751, 246.07803426087463

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.9116467513066, 255.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back