1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17967718.csml convertedTime:2009.07.01.11:09

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Regulatory pathways in inflammation.
Authors Mantovani A, Garlanda C, Locati M, Rodriguez TV, Feo SG, Savino B, Vecchi A.
Affiliation Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy.alberto.mantovani@humanitas.it
Abstract Tuning is a key aspect of inflammatory reaction essential in homeostasis andpathology. An emerging mechanism for negative regulation of proinflammatorycytokines is based on non-signaling IL-1/TLR receptors and chemokine receptorscompeting with signaling receptors for ligand binding and sustaining ligandinternalization and degradation. Biological activities of IL-1R/TLR receptorsare under control of membrane-bound binding molecules lacking the signalingdomain, soluble receptor antagonists, and intracellular signaling inhibitors.The chemokine system includes at least three 'silent' receptors with distinctspecificity and tissue distribution. D6 is the best characterized representativemember of this class of negative regulators, binds most inflammatory, but nothomeostatic, CC chemokines and shuttles in a ligand-independent way from theplasma membrane to endocytic compartments where chemokines are targeted todegradation. In vitro and in vivo evidence, including results with gene targetedmice, is consistent with the view that these non-signaling receptors forproinflammatory cytokines possess unique functional and structural featureswhich make them ideally adapted to act as a decoy and scavenger receptors, witha non redundant role in dampening tissue inflammation and tuning draining lymphnodes reactivity.
PMID 17967718
Model Abstract

Entity

MO000000214:IL-1 MO000016596:IL-1RII MO000016601:sIL-1RII e1: e10: e11:IL-1R e12:IL-1:IL-1R e13:AcP complex e14:ILR-II:AcP complex e15:D6 e16:D6 ligand: D6 receptor e17:D6 ligand e18:MYD88 e19:IL-1:IL-1R:MYD88 e2: e20:IRAK1 e21:IRAK4 e22:IL-1:IL-1R:MYD88:IRAK1:IRAK4 e23:IRAK-M e24:MYD88s e3: e4: e5:sIL-RII:IL-1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL-1:IL-1RII e60: e61: e62: e7: e8: e9:

Process

p1 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
983.0, 111.0
26.0, 26.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
919.0, 219.0
26.0, 26.0

IL-1RII

--

MO000016596

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4

true true true true

csml-variable:Double

m1590

10

false

infinite

0

unit false false false

--

Go back
1061.0, 97.0
22.0, 22.0

sIL-1RII

--

MO000016601

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m1595

10

false

infinite

0

unit false false false

--

Go back
250.12607698033156, 134.59354153591914
709.4323791374874, 1030.0958145076304

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
256.9614085571677, 150.3380790805013
687.6572223651093, 967.3403532673711

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
861.5, 147.34622144112473
21.224956063268888, 32.65377855887522

IL-1R

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
795.5, 142.28392896294667
17.936636702477525, 34.716071037053275

IL-1:IL-1R

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
668.5, 216.81629656817762
22.34832079280603, 31.183703431822366

AcP complex

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
716.0, 143.55882352941182
24.26470588235294, 40.44117647058824

ILR-II:AcP complex

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
572.5, 145.23374340949033
23.89806678383128, 36.76625659050966

D6

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
491.5, 146.37601403201054
17.889059416794563, 34.623985967989476

D6 ligand: D6 receptor

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
558.0, 26.636647212718863
28.967599114509966, 17.863352787281144

D6 ligand

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
675.0, 321.3454417387804
34.30468907224794, 21.154558261219563

MYD88

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
923.5, 382.75518443751145
24.542117819783453, 34.24481556248854

IL-1:IL-1R:MYD88

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6 p8 p9

p7

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
250.12607698033156, 134.59354153591914
709.4323791374874, 1030.0958145076304

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
619.0, 438.58
34.559999999999995, 25.92

IRAK1

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8 p9

p7

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
644.5, 521.7007446166231
23.001207486415773, 37.29925538337694

IRAK4

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8 p9

p7

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
925.0, 693.8235294117646
21.705882352941178, 36.1764705882353

IL-1:IL-1R:MYD88:IRAK1:IRAK4

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8 p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
752.0, 600.3564078578111
16.74555659494855, 38.643592142188965

IRAK-M

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
514.0, 574.6783054940634
32.14328838800563, 19.821694505936808

MYD88s

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
264.31472456308126, 148.7821891186689
681.0550839719878, 1001.7185193421312

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
290.5637225911684, 173.61232238848083
628.557087915814, 952.0582528025069

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1059.5, 237.13497750374938
24.389768371938008, 29.865022496250614

sIL-RII:IL-1

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
441.9658104724831, 736.9402206844818
225.59043102345845, 339.10408739831985

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
405.32532645274955, 733.3184223431884
375.74457141805345, 340.54096912458385

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
406.0437673158815, 734.0368632063207
374.3076896917892, 339.10408739831985

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
406.0437673158815, 734.0368632063207
374.3076896917892, 339.10408739831985

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
681.9250587585818, 872.3367293592372
24.102835619252946, 21.81940908690269

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
618.7022628029633, 972.9184501977219
68.25188199754312, 61.78591422935495

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
400.29624041082525, 728.6485567328303
385.80274350190166, 349.8807003453004

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
924.0, 283.3646408839779
23.071823204419893, 25.635359116022105

IL-1:IL-1RII

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3 p6

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
491.2277762916027, 884.1326488782543
12.217806009120668, 5.882647337724771

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
490.8197891654613, 866.5892024541806
41.81868042947776, 75.27362477305998

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
508.3632355895353, 915.5476575911305
6.527794018259936, 6.52779401825994

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
259.44698367601734, 138.73872852587002
695.7321412192787, 985.8344731668011

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
261.93255879486685, 156.1377543578169
667.4241332560883, 969.0998414878402

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
268.56075911179903, 173.53678018976376
664.3769759826822, 956.3903399011755

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1062.0, 178.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 MO000016601

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m185*m1595*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
987.0, 199.0
17.0, 17.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 MO000016596

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m185*m1590*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
870.0, 66.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 e11 e6 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c9 : 1

m185*m11*0.1

nodelay

--

true

0

false

PMID: 17967718 IL-1RII, which lacks a signaling domain, both in membrane-bound or released form, binds IL-1 preventing its interaction with a signaling receptor complex

Go back
830.0, 222.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016596

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m13*m1590*0.1

nodelay

--

true

0

false

PMID: 17967718, 8332913, 7848516, 11377293 In addition, it forms a dominant negative non signaling complex with the accessory protein (AcP)

Go back
518.0, 94.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 e17

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1

m15*m17*0.1

nodelay

--

true

0

false

PMID: 17967718 D6 binds a broad range of ligands that includes most of the inflammatory CC chemokines

Go back
990.0, 322.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m6*m18*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1043.0, 443.0
17.0, 17.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19*m20*m21*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1097.0, 609.0
21.0, 21.0

p8

p8

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e22 e23

e19 e21 e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c29 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m22*m23*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1034.0, 702.0
19.0, 19.0

p9

p9

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e22 e24

e19 e21 e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c34 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m22*m24*0.1

nodelay

--

true

0

false

PMID: 17967718, 15308102, 12538665 A negative regulation of signal transduction is exerted by IRAK-M, one of the members of the IL-1 receptor associated kinase (IRAK) family, which lacks kinase activity and regulates the dissociation of IRAK-1 and IRAK-4 from the adaptor protein MyD88, and by MyD88s a spliced form of MyD88 which prevents IRAK-4 recruitment.

Go back
1009.0, 135.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.997736944133, 88.87356695957513

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
891.9464699071453, 86.70523845275918

c11

c11

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
691.0, 232.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 232.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.8262546692157, 175.1716000756318

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.506083455352, 118.80370958807373

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.49018805215496, 113.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.3743112075098, 45.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 302.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 332.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 119.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.4630710245168, 341.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 405.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.0, 452.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 455.7288266937595

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.2491077284276, 460.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 629.7647058823529

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.9137774736627, 421.313065098613

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.8773424626189, 543.3955198768276

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.5350890719349, 460.68745840488873

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 620.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1072.0, 197.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0, 712.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
944.6250794501946, 424.5570469020753

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.30802009874, 548.2546646887831

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.7397812930657, 467.3099127742499

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 589.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
996.0, 137.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 213.8479626207359

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.5280520215392, 216.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.3892583745637, 83.0657561341275

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 92.9628001084424

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.3768447422535, 85.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back