1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17974478.csml convertedTime:2009.07.01.11:09

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors: novel pharmacological targets for the treatment ofneurological diseases.
Authors Marsh BJ, Stenzel-Poore MP.
Affiliation Department of Molecular Microbiology and Immunology, L220, Oregon Health andSciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.marshb@ohsu.edu
Abstract Toll-like receptors (TLRs) are a family of evolutionarily conserved moleculesthat directly detect pathogen invasion or tissue damage and initiate abiological response. TLRs can signal through two primary intracellular pathwaysand as such can induce either immuno-stimulatory or immuno-modulatory molecules.Both sides of this twin-edged sword are being examined for their therapeuticpotential in combating neurological disease. The immuno-stimulatory propertiesof TLRs are being used to generate tumor-specific immune responses to CNS tumorswhile the immuno-modulatory properties are being used to suppress damaginginflammatory responses to stroke. Recently, a third component of TLR signalinghas begun to emerge--that of direct neuroprotection. Hence, the TLRs offer noveltargets for the treatment of neurological disease.
PMID 17974478
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010365:TGFB2 G011345:IL10 G011599:IL-9 G011953:IL11 G012199:BDNF G014830:PTN MO000000058:NF-kappaB MO000000212:TRAF6 MO000000233:IkappaB-alpha MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016882:LPS MO000016963:TRAF3 MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000068831:MAL e1: e10: e11:ssRNA e12:ssRNA: TLR7 e13:CpG DNA e14:CpG DNA: TLR9 e15:TLR ligand e16:TLR ligand: TLR e17:TLR ligand: TLR: MyD88: TIRAP: MAL e18:TLT ligand: TLR: TRAM: TRIF e19:IRAK1 e2: e20:TLR ligand: TLR: MyD88: TIRAP: MAL: IRAK1: IRAK-4 e21:dsRNA:TLR3: TRIF e22:TLR ligand: TLR: MyD88: TIRAP: MAL: IRAK1: IRAK-4: TRAF6 e23:TAK1 [activated} e24:IKK-alpha:IKK-beta:IKK-gamma e25:IKK-alpha:IKK-beta:IKK-gamma {activated} e26:IkappaB-alpha e27:NF-kappaB {activated} e28:NF-kappaB {nucleus} e29:dsRNA:TLR3: TRIF: IKK-i: TBK1: NAP1 e3: e30:NAP1 e31:TRAF3 {activated} e32:dsRNA:TLR3: TRIF: IKK-i {p}: TBK1: NAP1 e33:IRF-3 {activated} e34:IRF-3 {nucleus} e35:IRF-7 {activated} e36:imiquimod e37:imiquimod: TLR7 e38:endigenous RNA e39:endigenous RNA: TLR3 e4: e40:poly (I:C) e41:poly (I:C): TLR3 e42:neurotrophin 4 e43:ephrin type B receptor 1 e5:PGN: TLR2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS: TLR4 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p4 p5 p6 p7 p8 p9
Model Detail
549.0, 741.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24 p28

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
668.0, 936.0
32.0, 32.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
718.0, 910.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
594.0, 914.0
36.0, 36.0

TGFB2

--

G010365

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m93341

10

false

infinite

0

unit false false false
TRANSFACG010365

--

Go back
482.0, 954.0
28.0, 28.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
449.0, 893.0
30.0, 30.0

IL-9

--

G011599

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m94447

10

false

infinite

0

unit false false false
TRANSFACG011599

--

Go back
475.0, 1019.0
34.0, 34.0

IL11

--

G011953

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m94762

10

false

infinite

0

unit false false false
TRANSFACG011953

--

Go back
596.0, 816.0
31.0, 31.0

BDNF

--

G012199

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p30

--

true true true true

csml-variable:Double

m94997

10

false

infinite

0

unit false false false
TRANSFACG012199

--

Go back
596.0, 868.0
31.0, 31.0

PTN

--

G014830

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m96923

10

false

infinite

0

unit false false false
TRANSFACG014830

--

Go back
725.0, 461.0
38.0, 38.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
533.0, 249.0
30.0, 30.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
726.0, 382.0
36.0, 36.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
361.0, 441.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
424.0, 364.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
475.0, 187.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
744.0, 244.0
39.5, 39.5

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
286.0, 198.0
28.0, 28.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
989.0, 141.0
30.0, 30.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
364.0, 304.0
32.5, 32.5

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
300.0, 244.0
32.0, 32.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
922.0, 158.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
426.0, 146.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
129.0, 605.0
29.0, 29.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
134.0, 322.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p27 p29

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
37.0, 265.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
529.0, 189.0
30.0, 30.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
681.0, 189.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
329.0, 193.0
29.5, 29.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p10

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
381.0, 189.0
29.0, 29.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
127.0, 267.0
34.0, 34.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
129.0, 865.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
59.0, 607.0
25.0, 25.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
127.0, 755.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p26

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
579.0, 187.0
34.0, 34.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
107.75, 106.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
116.0, 126.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
53.0, 652.25
30.0, 15.5

ssRNA

--

e11

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
130.75, 696.0
26.810781536410598, 32.82952841193134

ssRNA: TLR7

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
36.0, 868.75
40.42316258351893, 14.148106904231623

CpG DNA

--

e13

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
131.75, 917.0
24.5, 30.0

CpG DNA: TLR9

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
497.0, 42.25
30.0, 19.5

TLR ligand

--

e15

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
482.75, 136.0
26.19021829695051, 32.069655057490415

TLR ligand: TLR

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p7 p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
599.25, 116.0
34.4102587630758, 48.01431455312901

TLR ligand: TLR: MyD88: TIRAP: MAL

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
320.25, 110.0
32.15333088640118, 44.865112864745825

TLT ligand: TLR: TRAM: TRIF

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
632.0, 188.0
32.0, 32.0

IRAK1

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
TRANSPATHMO000046974

--

Go back
107.75, 106.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
718.25, 107.0
35.317764727472934, 49.28060194531106

TLR ligand: TLR: MyD88: TIRAP: MAL: IRAK1: IRAK-4

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
262.25, 121.0
27.59212699577904, 38.500642319691686

dsRNA:TLR3: TRIF

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
793.25, 94.0
37.28271242429804, 52.022389429253074

TLR ligand: TLR: MyD88: TIRAP: MAL: IRAK1: IRAK-4: TRAF6

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
840.0, 244.0
39.5, 39.5

TAK1 [activated}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
717.0, 313.0
38.0, 38.0

IKK-alpha:IKK-beta:IKK-gamma

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
849.0, 305.0
38.0, 38.0

IKK-alpha:IKK-beta:IKK-gamma {activated}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
854.0, 382.0
36.0, 36.0

IkappaB-alpha

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
849.0, 461.0
38.0, 38.0

NF-kappaB {activated}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
677.0, 781.0
38.0, 38.0

NF-kappaB {nucleus}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
154.25, 133.0
37.42475683611672, 52.22059093411635

dsRNA:TLR3: TRIF: IKK-i: TBK1: NAP1

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
124.87518862352903, 124.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
241.0, 237.0
30.0, 30.0

NAP1

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
Affymetrix1452196_a_at
EnsemblENSMUSG00000027002
MGDNckap1
ProteomeHumanPSD/Nckap1
RefSeqNM_016965
TRANSPATHMO000079906
UnigeneMm.25203
UniProtP28660

--

Go back
280.0, 364.0
32.5, 32.5

TRAF3 {activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
128.25, 191.0
30.709212699577904, 42.85006423196917

dsRNA:TLR3: TRIF: IKK-i {p}: TBK1: NAP1

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
361.0, 505.0
30.0, 30.0

IRF-3 {activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
577.0, 705.0
30.0, 30.0

IRF-3 {nucleus}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
428.0, 420.0
32.0, 32.0

IRF-7 {activated}

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
48.0, 820.5
39.91589571068124, 22.61900756938604

imiquimod

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p26

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
135.75, 805.0
24.5, 30.0

imiquimod: TLR7

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
211.0, 380.75
42.20729366602688, 23.214011516314777

endigenous RNA

--

e38

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
135.75, 433.0
24.5, 30.0

endigenous RNA: TLR3

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
156.55678757705792, 154.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
43.0, 496.5
41.63162321278385, 23.59125315391085

poly (I:C)

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
129.75, 486.0
28.63981003166139, 35.06915514080986

poly (I:C): TLR3

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
546.0, 823.0
35.501730103806224, 18.934256055363324

neurotrophin 4

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
533.0, 874.0
37.37024221453287, 19.930795847750865

ephrin type B receptor 1

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
131.75, 549.0
24.5, 30.0

PGN: TLR2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
307.0, 681.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
357.29367619468036, 691.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
313.06992643728904, 686.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
313.93705878547314, 687.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
307.0, 681.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
307.0, 681.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
313.93705878547314, 687.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
646.9158804881849, 854.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
570.6082338479803, 975.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
307.0, 681.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
921.75, 222.0
28.63981003166139, 35.06915514080986

LPS: TLR4

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
416.7511016961721, 868.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
416.25867587120234, 847.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
437.43298634490145, 906.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
119.0, 112.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
122.0, 133.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
130.0, 154.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
57.0, 549.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 17974478 The Toll-like receptors, so-called because of their homology to the Drosophila Toll receptor, were first characterized in mammals by their ability to recognize pathogen-associated molecules such as the bacterial cell wall components peptidoglycan (TLR2) and lipopolysaccharide (TLR4), as well as dsRNA (TLR3), ssRNA (TLR7), and nonmethylated Cytosine-Guanosine (CpG) DNA (TLR9).

Go back
261.0, 53.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

--

Go back
737.0, 189.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m20*m183*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
793.0, 189.0
30.0, 30.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m22*m1573*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
789.0, 317.0
30.0, 30.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m23*m24*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
793.0, 385.0
30.0, 30.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m25*m199*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
789.0, 465.0
30.0, 30.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
753.0, 653.0
30.0, 30.0

p16

p16

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
713.0, 849.0
30.0, 30.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
669.0, 857.0
30.0, 30.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
213.0, 141.0
30.0, 30.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m21*m1599*m3902*m31*0.1

nodelay

--

true

0

false

PMID: 17974478 TLR3, on the other hand, signals through the MyD88 independent pathway, initiated by the TRIF adaptor molecule.

Go back
37.0, 321.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17974478 The Toll-like receptors, so-called because of their homology to the Drosophila Toll receptor, were first characterized in mammals by their ability to recognize pathogen-associated molecules such as the bacterial cell wall components peptidoglycan (TLR2) and lipopolysaccharide (TLR4), as well as dsRNA (TLR3), ssRNA (TLR7), and nonmethylated Cytosine-Guanosine (CpG) DNA (TLR9).

Go back
281.0, 305.0
30.0, 30.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c67 : 1
stoichiometry:c63 : 1

m1872*m33*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
285.0, 441.0
30.0, 30.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m32*m977*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
577.0, 505.0
30.0, 30.0

p22

p22

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
205.0, 197.0
29.0, 29.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c65 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
629.0, 741.0
30.0, 30.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
353.0, 365.0
30.0, 30.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m980*m32*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of TRIF to the receptor initiates phosphorylation of IKKe, which activates the transcription factors IRF3 and IRF7.

Go back
53.0, 753.0
30.0, 30.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m37*m19940*0.1

nodelay

--

true

0

false

PMID: 17974478 One particularly attractive candidate for cancer immunotherapy is imiquimod, a synthetic TLR7 agonist that has been given FDA approval as a topical treatment for HSV-2 lesions.

Go back
133.0, 377.0
30.0, 30.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m3965*m39*0.1

nodelay

--

true

0

false

PMID: 17974478, 14729660 TLR3 detects viral dsRNA and can be activated by endogenous RNA released from necrotic cells.

Go back
512.0, 708.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c82 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478, 17085778, 15356140, 17061254 Microglia, neurons and astrocytes all produce IFNbeta upon stimulation with the synthetic TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)).

Go back
49.0, 441.0
30.0, 30.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m3965*m41*0.1

nodelay

--

true

0

false

PMID: 17974478, 17085778, 15356140, 17061254 Microglia, neurons and astrocytes all produce IFNbeta upon stimulation with the synthetic TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C)). PMID: 17974478 TLR3 offers substantial promise as a novel therapeutic target in neuroprotection against CNS-related injury.

Go back
989.0, 225.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17974478 The Toll-like receptors, so-called because of their homology to the Drosophila Toll receptor, were first characterized in mammals by their ability to recognize pathogen-associated molecules such as the bacterial cell wall components peptidoglycan (TLR2) and lipopolysaccharide (TLR4), as well as dsRNA (TLR3), ssRNA (TLR7), and nonmethylated Cytosine-Guanosine (CpG) DNA (TLR9).

Go back
463.0, 723.0
25.0, 25.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c87 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
424.0, 736.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c88 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
394.0, 766.0
27.0, 27.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c89 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
371.0, 803.0
25.0, 25.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c90 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
370.0, 842.0
27.0, 27.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
372.0, 896.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c100 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
384.0, 956.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c101 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
395.0, 1023.0
25.0, 25.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c102 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17974478 Astrocytes isolated from post mortem human adult subjects and stimulated with poly(I:C) induce the expression of multiple neuroprotective molecules (BDNF, neurotrophin 4, pleiotrophin, ephrin type B receptor1, TGFb2) and anti-inflammatory cytokines (IL-9, IL-10, IL-11).

Go back
53.0, 697.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m11*m19940*0.1

nodelay

--

true

0

false

PMID: 17974478 The Toll-like receptors, so-called because of their homology to the Drosophila Toll receptor, were first characterized in mammals by their ability to recognize pathogen-associated molecules such as the bacterial cell wall components peptidoglycan (TLR2) and lipopolysaccharide (TLR4), as well as dsRNA (TLR3), ssRNA (TLR7), and nonmethylated Cytosine-Guanosine (CpG) DNA (TLR9).

Go back
41.0, 917.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m13*m19828*0.1

nodelay

--

true

0

false

PMID: 17974478 The Toll-like receptors, so-called because of their homology to the Drosophila Toll receptor, were first characterized in mammals by their ability to recognize pathogen-associated molecules such as the bacterial cell wall components peptidoglycan (TLR2) and lipopolysaccharide (TLR4), as well as dsRNA (TLR3), ssRNA (TLR7), and nonmethylated Cytosine-Guanosine (CpG) DNA (TLR9). PMID: 17974478 Perhaps the most promising TLR ligands in the fight against cancers of the CNS are the TLR9 agonists, nonmethylated CpG oligodeoxynucleotides.

Go back
425.0, 37.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m3962*m15*0.1

nodelay

--

true

0

false

PMID: 17974478 Each TLR family member, with the exception of TLR3, signals through the MyD88 dependent pathway, initiated by the MyD88 adaptor protein.

Go back
529.0, 109.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m1572*m6810*m43675*m16*0.1

nodelay

--

true

0

false

PMID: 17974478 Each TLR family member, with the exception of TLR3, signals through the MyD88 dependent pathway, initiated by the MyD88 adaptor protein.

Go back
361.0, 53.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19005*m16*m18998*0.1

nodelay

--

true

0

false

--

Go back
661.0, 125.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m17*m19*m17258*0.1

nodelay

--

true

0

false

PMID: 17974478 Recruitment of MyD88 to the activated receptor initiates formation of the IL-1 receptor associated kinase (IRAK) complex resulting in phosphorylation of IKKalpha/bbeta, activation of the transcription factors NFkappaB, AP1, IRF1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFalpha.

Go back
72.0, 587.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 668.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
395.0, 908.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
407.0, 968.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 1036.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
89.33028001113733, 728.8915800086061

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.0, 712.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
56.0, 883.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
77.90158376078126, 889.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
71.0, 932.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 75.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.0, 52.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 67.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.0, 145.72031502215017

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.36345376025999, 580.8483457221029

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 147.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.3402034518053, 145.72031502215017

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 136.85534999817725

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.0, 127.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
379.1940215386404, 90.91039269349271

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.41449998687756, 90.23472113074257

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.0, 90.78547690221129

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.2625061574891, 83.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 140.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.0, 162.36465425500205

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
87.0, 564.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.2573305919324, 162.67492401257016

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 135.1723892887157

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
35.96418204672163, 67.81794526028665

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.5253855251153, 90.18134088449416

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 83.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
741.0, 156.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 210.29069888784727

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 152.4894110299791

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
809.3716911948197, 146.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 225.49227473161196

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 336.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 219.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0659023220582, 284.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
755.0, 332.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 327.0573097607281

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.9425724154552, 343.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
762.0, 400.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.0, 400.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.1849490362268, 418.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 480.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 480.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
67.0, 296.944100575847

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.7599452004841, 499.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.8608380291771, 683.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.247700587784, 819.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 819.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
684.0, 887.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 879.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.62866132107314, 145.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.34647460872222, 172.8705502811124

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.17876232316425, 177.09757499340307

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.9909451017955, 157.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
52.0, 295.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
234.32005916226296, 178.65619523546778

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.0, 181.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.0, 320.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 335.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 397.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
167.0, 212.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 456.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 223.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
315.0, 469.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.0, 520.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 171.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 535.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 756.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 730.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
391.0, 380.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
383.0, 391.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.0, 380.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
68.0, 791.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.0, 768.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.0, 778.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 350.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 186.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
171.0, 392.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
148.0, 407.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 730.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
78.60216585058384, 350.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
64.0, 479.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
79.0, 465.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 512.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
488.0, 744.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.0, 755.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 787.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.0, 240.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 821.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
158.0, 514.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 516.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
158.0, 519.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.0, 521.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
156.0, 521.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 860.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
154.0, 521.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
153.0, 521.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
152.0, 521.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back